High risk of Kaposi's sarcoma and central nervous system lymphoma in the same individuals: a finding related to acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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High risk of Kaposi's sarcoma and central nervous system lymphoma in the same individuals: a finding related to acquired immunodeficiency syndrome.

Int J Cancer. 1996 Apr 10;66(2):176-8. Unique Identifier : AIDSLINE MED/96179485
Ahsan H; Neugut AI; Division of Epidemiology, School of Public Health, Columbia; University, NY, USA.

Abstract: Kaposi's sarcoma and central nervous system (CNS) lymphoma are the 2 most common malignancies related to HIV infection. To investigate the association between Kaposi's sarcoma and CNS lymphoma, a population-based retrospective cohort study was conducted. Using U.S. Surveillance, Epidemiology and End Results Program data, the gender-specific age- and calendar year-adjusted standardized incidence ratios were calculated for the pre-AIDS (1973-80) and AIDS (1981-1990) eras, as an estimate of the relative risk (RR) of developing one condition following another. For the AIDS era in men, the RR of CNS lymphoma following Kaposi's sarcoma was 979.7 and that of Kaposi's sarcoma following CNS lymphoma was 231.1. There were no instances of the co-occurrence of these malignancies in women in either era or in men for the pre-AIDS era. The extremely high RRs for the co-occurrence of Kaposi's sarcoma and CNA lymphoma in men during the AIDS era suggests that the association of these malignancies occurs within the same HIV-infected individuals.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Aged Brain Neoplasms/*ETIOLOGY Cohort Studies Female Human Lymphoma, AIDS-Related/*ETIOLOGY Male Middle Age Neoplasms, Second Primary/*ETIOLOGY Retrospective Studies Sarcoma, Kaposi's/*ETIOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultagedbrainneoplasms/KWDetiologycohortstudiesfemalehumanlymphoma,aids-related/KWDetiologymalemiddleageneoplasms,secondprimary/KWDetiologyretrospectivestudiessarcoma,kaposi's/KWDetiologyjournalarticle
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M9670369

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