Serum cytokine profiles in acute primary HIV-1 infection and in infectious mononucleosis. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Serum cytokine profiles in acute primary HIV-1 infection and in infectious mononucleosis.

Clin Immunol Immunopathol. 1996 Jan;78(1):61-9. Unique Identifier : AIDSLINE MED/96173871
Biglino A; Sinicco A; Forno B; Pollono AM; Sciandra M; Martini C; Pich P; Gioannini P; Institute of Infectious Disease, University of Turin, Italy.

Abstract: Serum cytokine profiles, T-cell subsets, and general parameters of immune activation were evaluated in 15 patients with acute primary HIV-1 infection, and compared with those obtained from 18 patients with acute primary Epstein-Barr virus (EBV) infection and from 18 control subjects in order to elucidate possible defects of immune response to HIV in early phases of virus-host interaction. Mean CD4+ cell count, serum concentrations of interleukin (IL)-2, IL-4, soluble IL-2 receptor (sIL-2R), tumor necrosis factor (TNF)-alpha, 5'-neopterin, and beta 2-microglobulin were significantly lower in acute HIV-1 infection than in EBV infection. Both acute HIV-1 and EBV infections were characterized by significantly higher mean CD8+ cell count and soluble CD8 antigen (sCD8) levels compared to control subjects, while acute HIV-1 infection was accompanied by the highest interferon (IFN)-gamma serum concentrations. In primary HIV-1 infection, significant impairment of CD4+- mediated T-helper function may lead to viral escape and persistence of infection despite an early and vigorous CD8+ T-lymphocyte activation.
Keywords: beta 2-Microglobulin/ANALYSIS Acute Disease Adolescence Adult Biopterin/ANALOGS & DERIVATIVES/BLOOD Cytokines/*BLOOD Female Human HIV Infections/BLOOD/*IMMUNOLOGY HIV-1/*IMMUNOLOGY Infectious Mononucleosis/BLOOD/*IMMUNOLOGY Lymphocyte Count Lymphocyte Transformation Macrophage Activation Male Middle Age Receptors, Interleukin-2/ANALYSIS Support, Non-U.S. Gov't JOURNAL ARTICLEKWDbeta2-microglobulin/analysisacutediseaseadolescenceadultbiopterin/analogs&derivatives/bloodcytokines/KWDbloodfemalehumanhivinfections/blood/KWDimmunologyhiv-1/KWDimmunologyinfectiousmononucleosis/blood/KWDimmunologylymphocytecountlymphocytetransformationmacrophageactivationmalemiddleagereceptors,interleukin-2/analysissupport,non-uKWDsKWDgov'tjournalarticle
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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