Bone marrow involvement by disseminated toxoplasmosis in acquired immunodeficiency syndrome: the value of bone marrow trephine biopsy and immunohistochemistry for the diagnosis.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Bone marrow involvement by disseminated toxoplasmosis in acquired immunodeficiency syndrome: the value of bone marrow trephine biopsy and immunohistochemistry for the diagnosis.

Hum Pathol. 1996 Mar;27(3):302-6. Unique Identifier : AIDSLINE MED/96180304
Brouland JP; Audouin J; Hofman P; Le Tourneau A; Basset D; Rio B; Zittoun R; Diebold J; Service Central d'Anatomie et de Cytologie Pathologiques,; Hotel-Dieu, Paris, France.

Abstract: A bone marrow biopsy was performed on four patients with acquired immune deficiency syndrome (AIDS) for a long-running course fever of unknown origin associated with a recent pancytopenia. In the four cases, striking histological similarities, such as interstitial edema, foci of necrosis and only few scattered or clustered histiocytes, were found. Near or in the foci of necrosis, free forms, and pseudocysts of Toxoplasma gondii were observed not only in the cytoplasm of macrophages and of some granulocytes, but also within megakaryocytes. No sign of other parasitic, bacterial, or fungus infection has been found. The diagnosis was confirmed by immunohistochemistry in the four cases and ultrastructural examination in one case. This case study stresses the importance of bone marrow histological changes for the diagnosis of severe toxoplasmosis in AIDS patients and particularly the localization of T gondii within the cytoplasm of megakaryocytes.

Keywords: Adult Animal AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY/ PARASITOLOGY Biopsy Bone Marrow/PATHOLOGY/*PARASITOLOGY Bone Marrow Diseases/*DIAGNOSIS/PATHOLOGY/PARASITOLOGY Case Report Edema/PATHOLOGY Female Granulocytes/PATHOLOGY/PARASITOLOGY Human Immunohistochemistry Male Megakaryocytes/PATHOLOGY/PARASITOLOGY Microscopy, Electron Middle Age Toxoplasma/*ISOLATION & PURIF Toxoplasmosis/*DIAGNOSIS/PATHOLOGY/PARASITOLOGY JOURNAL ARTICLE
960730
M9670504

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .