Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid.

Science. 1996 Apr 5;272(5258):115-7. Unique Identifier : AIDSLINE MED/96178679
Frankel SS; Wenig BM; Burke AP; Mannan P; Thompson LD; Abbondanzo SL; Nelson AM; Pope M; Steinman RM; AIDS Division, Department of Infectious and Parasitic Disease; Pathology, Armed Forces Institute of Pathology, Washington DC; 20306-6000, USA.

Abstract: Human immunodeficiency virus-type 1 (HIV-1) replicates actively in infected individuals, yet cells with intracellular depots of viral protein are observed only infrequently. Many cells expressing the HIV-1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid. This infected mucosal surface contained T cells and dendritic cells, two cell types that together support HIV-1 replication in culture. The infected cells were multinucleated syncytia and expressed the S100 and p55 dendritic cell markers. Eleven of the 13 specimens analyzed were from donors who did not have symptoms of acquired immunodeficiency syndrome (AIDS). The interaction of dendritic cells and T cells in mucosa may support HIV-1 replication, even in subclinical stages of infection.
Keywords: Adenoids/CHEMISTRY/*VIROLOGY Adult Dendritic Cells/PHYSIOLOGY/*VIROLOGY Female Germinal Center/CHEMISTRY/VIROLOGY Giant Cells/*VIROLOGY Human HIV Core Protein p24/ANALYSIS HIV Infections/*VIROLOGY HIV-1/*PHYSIOLOGY In Situ Hybridization Keratin/ANALYSIS Male Mucous Membrane/CHEMISTRY/VIROLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. T-Lymphocytes/PHYSIOLOGY Virus Replication JOURNAL ARTICLEKWDadenoids/chemistry/KWDvirologyadultdendriticcells/physiology/KWDvirologyfemalegerminalcenter/chemistry/virologygiantcells/KWDvirologyhumanhivcoreproteinp24/analysishivinfections/KWDvirologyhiv-1/KWDphysiologyinsituhybridizationkeratin/analysismalemucousmembrane/chemistry/virologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/physiologyvirusreplicationjournalarticle
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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