Immunological memory and protective immunity: understanding their relation.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Immunological memory and protective immunity: understanding their relation.

Science. 1996 Apr 5;272(5258):54-60. Unique Identifier : AIDSLINE MED/96178661
Ahmed R; Gray D; Emory Vaccine Center, Emory University School of Medicine,; Atlanta, GA, USA.

Abstract: The immune system can remember, sometimes for a lifetime, the identity of a pathogen. Understanding how this is accomplished has fascinated immunologists and microbiologists for many years, but there is still considerable debate regarding the mechanisms by which long-term immunity is maintained. Some of the controversy stems from a failure to distinguish between effector and memory cells and to define their roles in conferring protection against disease. Here the current understanding of the cellular basis of immune memory is reviewed and the relative contributions made to protective immunity by memory and effector T and B cells are examined.

Keywords: Animal Antibody Formation Antigens/IMMUNOLOGY B-Lymphocytes/CYTOLOGY/*IMMUNOLOGY Cell Differentiation Cell Lineage CD4-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY CD8-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY Human Immunologic Memory/*IMMUNOLOGY Infection/IMMUNOLOGY Lymphocyte Transformation Plasma Cells/IMMUNOLOGY Receptors, Antigen, T-Cell/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
960730
M9670495

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