Population dynamics of immune responses to persistent viruses.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Population dynamics of immune responses to persistent viruses.

Science. 1996 Apr 5;272(5258):74-9. Unique Identifier : AIDSLINE MED/96178671
Nowak MA; Bangham CR; Department of Zoology, University of Oxford, UK.

Abstract: Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).

Keywords: Antibodies, Viral/IMMUNOLOGY Antigenic Variation Antigens, Viral/IMMUNOLOGY Cytokines/IMMUNOLOGY Cytotoxicity, Immunologic Epitopes/IMMUNOLOGY Human HIV Infections/IMMUNOLOGY/VIROLOGY HIV-1/IMMUNOLOGY/PHYSIOLOGY HTLV-I/GENETICS/IMMUNOLOGY/PHYSIOLOGY HTLV-I Infections/IMMUNOLOGY/VIROLOGY *Models, Biological Mutation Population Dynamics Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/*IMMUNOLOGY Variation (Genetics) Virus Diseases/*IMMUNOLOGY/VIROLOGY Virus Replication Viruses/GENETICS/*IMMUNOLOGY/PHYSIOLOGY JOURNAL ARTICLE
960730
M9670494

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .