Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.
Mouse parvovirus infection potentiates rejection of tumor allografts and modulates T cell effector functions.
Transplantation. 1996 Jan 27;61(2):292-9. Unique Identifier : AIDSLINE MED/96166738 McKisic MD; Paturzo FX; Smith AL; Section of Comparative Medicine, Yale University School of; Medicine, New Haven, Connecticut 06520, USA.
Abstract:
Lymphocytotropic mouse parvoviruses can perturb immune responses. For example the recently identified mouse parvovirus designated MPV-1 persistently infects lymphoid tissues and interferes with the ability of cloned T cells to proliferate. As a consequence of these findings the present studies were undertaken to characterize further the immunomodulatory effects of MPV-1 on T cell-mediated immune responses in vivo and in vitro. To evaluate the effect of MPV-1 on CD8+ T cell-mediated responses sarcoma I (SaI) cells, devoid of class II major histocompatibility (MHC) antigens, were administered to MPV-1-infected adult BALB/c mice. MPV-1 infection accelerated tumor allograft rejection. Immunofluorescence staining and in situ hybridization studies of tumors suggested that direct infection of the tumor cells was not responsible for accelerated rejection. Furthermore, compared with uninfected mice, T cells from infected mice that had rejected SaI tumors had a diminished cytolytic capacity. Taken together these results suggest that MPV-1 may induce bystander help. To examine the in vivo effect of MPV-1 on CD4+ T cell mediated responses adult mice were primed with ovalbumin (OVA) and infected with MPV-1. Spleen and popliteal lymph node cells from OVA-primed mice 3 or 7 days after MPV-1 inoculation had reduced proliferation responses, whereas the proliferative capacity of mesenteric lymph node cells from these mice was increased. Similarly, MPV-1 reduced cytokine-induced proliferation of allospecific CD8+ cloned L3 T cells and OVA-reactive CD4+ T cells without effecting cell viability. Since parvoviruses are widespread among laboratory rodents, these findings emphasize the importance of identifying and excluding parvovirus infections in mice used for transplantation studies and in cultures of mouse T lymphocytes.
Keywords: Animal CD4-Positive T-Lymphocytes/*IMMUNOLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY Graft Rejection/*IMMUNOLOGY/VIROLOGY Lymphocyte Transformation Mice Mice, Inbred BALB C Mice, Inbred CBA Neoplasm Transplantation/*IMMUNOLOGY/PATHOLOGY Parvoviridae Infections/*IMMUNOLOGY Parvovirus/*IMMUNOLOGY Sarcoma, Experimental/IMMUNOLOGY/PATHOLOGY/VIROLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Transplantation, Homologous JOURNAL ARTICLE 960730
M9670488
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Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.
