Stimulation of the CD2 receptor pathway induces apoptosis in human T lymphotropic virus type I-infected cell lines. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Stimulation of the CD2 receptor pathway induces apoptosis in human T lymphotropic virus type I-infected cell lines.

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Apr 1;11(4):317-25. Unique Identifier : AIDSLINE MED/96183594
Guyot DJ; Trask OJ; Andrews JM; Newbound GC; Lairmore MD; Center for Retrovirus and Department of Veterinary Biosciences,; College of Veterinary Medicine, Ohio State University, USA.

Abstract: We demonstrate that CD2 receptor engagement, but not CD3 crosslinking, induces apoptosis in lymphocytes transformed by human T-cell lymphotrophic virus type I (HTLV-I). Mitogenic pairs of anti-CD2 monoclonal antibodies inhibited [3H]thymidine incorporation from 25 to 62% in CD2+ HTLV-I-infected lymphocytes. This inhibition was associated with a 20-40% reduction in cell number and viability over a 3-day period, morphologic evidence of apoptosis, and irreversible DNA fragmentation. While cyclosporin A abrogated CD2-mediated proliferation in peripheral blood mononuclear cells, it had no effect on CD2-induced apoptosis in the HTLV-I-infected cell lines. Since HTLV-I is mitogenic to resting lymphocytes through CD2 activation pathways, these results suggest that HTLV-I-infected lymphocytes are primed for apoptosis following additional CD2 stimulation. This CD2-mediated apoptosis might be a factor in immune regulation of HTLV-I-associated diseases or might offer a novel adjunctive approach to treatment.
Keywords: Antigens, CD/BIOSYNTHESIS/PHYSIOLOGY Antigens, CD2/*PHYSIOLOGY Apoptosis/*PHYSIOLOGY Cell Division/DRUG EFFECTS Cell Line, Transformed Cell Survival Cyclosporine/PHARMACOLOGY DNA/METABOLISM Human HTLV-I/*PHYSIOLOGY Lymphocyte Count Lymphocyte Transformation Signal Transduction/PHYSIOLOGY Support, U.S. Gov't, P.H.S. T-Lymphocytes/*CYTOLOGY/VIROLOGY JOURNAL ARTICLEKWDantigens,cd/biosynthesis/physiologyantigens,cd2/KWDphysiologyapoptosis/KWDphysiologycelldivision/drugeffectscellline,transformedcellsurvivalcyclosporine/pharmacologydna/metabolismhumanhtlv-i/KWDphysiologylymphocytecountlymphocytetransformationsignaltransduction/physiologysupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes/KWDcytology/virologyjournalarticle
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M9670471

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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