Hepatitis B immunization: a potential incentive to HIV vaccine trial participation in Thailand? NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Hepatitis B immunization: a potential incentive to HIV vaccine trial participation in Thailand?

J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Apr 1;11(4):396-400. Unique Identifier : AIDSLINE MED/96183604
Beyrer C; Celentano DD; Linpisarn S; Natpratan C; Feng W; Eiumtrakul S; Khamboonruang C; Nelson KE; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, Maryland, USA.

Abstract: To assess the effectiveness of hepatitis B immunization as an incentive to retention in HIV seroincidence studies and future HIV vaccine trials in northern Thailand, subjects enrolled in three HIV seroincidence cohorts were screened for hepatitis B markers and seronegatives were offered free hepatitis B immunization. Cohorts studied included female commercial sex workers (CSWs), male sexually transmitted disease (STD) patients, and recently discharged military conscripts. Subjects who agreed to the immunization program were compared with those not enrolled to determine the utility of immunization as an incentive to cohort retention. Full immunization was achieved for 273 (89.5%) of 305 vaccinees; only 323 (60.6%) of 533 subjects not immunized completed the same follow-up visits (OR = 1.49, 95% and CI = 1.27, 1.75). Hepatitis B vaccination was a significant incentive for completion of the follow-up program. The vaccination program had the greatest effect on the CSWs; a similar effect was seen for male STD patients, but not for discharged conscripts. Despite the immunization program, follow-up rates at 12 months were similar in the immunized and nonimmunized groups.
Keywords: Adult *AIDS Vaccines *Clinical Trials Cohort Studies Female *Hepatitis B Vaccines Human Male Military Personnel *Motivation Prostitution Sexually Transmitted Diseases Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Thailand *Vaccination JOURNAL ARTICLEKWDadultKWDaidsvaccinesKWDclinicaltrialscohortstudiesfemaleKWDhepatitisbvaccineshumanmalemilitarypersonnelKWDmotivationprostitutionsexuallytransmitteddiseasessupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDthailandKWDvaccinationjournalarticle
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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