Magnetic resonance spectroscopy in childhood AIDS encephalopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Magnetic resonance spectroscopy in childhood AIDS encephalopathy.

Pediatr Neurol. 1995 May;12(4):277-82. Unique Identifier : AIDSLINE MED/96044396
Pavlakis SG; Lu D; Frank Y; Bakshi S; Pahwa S; Barnett TA; Porricolo ME; Gould RJ; Nozyce ML; Hyman RA; Department of Radiology, North Shore University Hospital,; Manhasset, New York, USA.

Abstract: Twenty-five children with acquired immunodeficiency syndrome (AIDS) underwent cranial magnetic resonance imaging and proton magnetic resonance spectroscopy. Patients were divided into 2 groups based on clinical parameters: encephalopathy and nonencephalopathy. N-acetyl aspartate/creatine ratios were compared between the 2 groups and to control data. Spectra were obtained for 2 volumes of interest: the basal ganglia region and the white matter. The mean basal ganglia region ratio for the AIDS encephalopathy patients (n = 8) was 1.12 and the ratio for the AIDS nonencephalopathy patients (n = 17) was 1.48. The ratio for the 9 controls was 1.57. The encephalopathy group had a significantly lower ratio than both the control (P < .001) and the AIDS nonencephalopathy group (P < .002). The mean white matter ratio for the encephalopathy group (n = 8) was 1.47 and for the AIDS nonencephalopathy group (n = 13) was 1.82 with a control (n = 6) ratio of 1.82. The encephalopathy patients had a lower white matter ratio than the nonencephalopathy (P < .05) patients but the ratio was not different than controls (P < .11). It is concluded that N-acetyl aspartate/creatine ratios are reduced in childhood AIDS encephalopathy and proton magnetic resonance spectroscopy may be helpful in defining brain human immunodeficiency virus-1 infection. However, further longitudinal studies are necessary to determine the sensitivity and specificity of this technique.
Keywords: Adolescence AIDS Dementia Complex/*DIAGNOSIS Basal Ganglia/*PATHOLOGY Case-Control Studies Child Child, Preschool Human Infant Magnetic Resonance Imaging *Nuclear Magnetic Resonance Protons Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadolescenceaidsdementiacomplex/KWDdiagnosisbasalganglia/KWDpathologycase-controlstudieschildchild,preschoolhumaninfantmagneticresonanceimagingKWDnuclearmagneticresonanceprotonssupport,non-uKWDsKWDgov'tjournalarticle
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Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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