Th1 and Th2 subsets: paradigms lost? NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Th1 and Th2 subsets: paradigms lost?

Immunol Today. 1995 Aug;16(8):374-9. Unique Identifier : AIDSLINE MED/96002281
Kelso A; Transplantation Biology Unit, Queensland Institute of Medical; Research, Brisbane, Australia.

Abstract: The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However, individual T cells and clones display remarkable diversity in their cytokine profiles, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of the possible extreme phenotypes. For these reasons, Anne Kelso argues that cytokine-producing T cells cannot be classified into discrete subsets.
Keywords: Animal Clone Cells/METABOLISM/SECRETION Cytokines/BIOSYNTHESIS/GENETICS/*SECRETION Gene Expression Regulation Immunization Immunophenotyping Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA *Models, Immunological Support, Non-U.S. Gov't *T-Lymphocyte Subsets Th1 Cells/*IMMUNOLOGY/METABOLISM/SECRETION Th2 Cells/*IMMUNOLOGY/METABOLISM/SECRETION JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalclonecells/metabolism/secretioncytokines/biosynthesis/genetics/KWDsecretiongeneexpressionregulationimmunizationimmunophenotypingmicemice,inbredbalbcmice,inbredc57blmice,inbreddbaKWDmodels,immunologicalsupport,non-uKWDsKWDgov'tKWDt-lymphocytesubsetsth1cells/KWDimmunology/metabolism/secretionth2cells/KWDimmunology/metabolism/secretionjournalarticlereviewreview,tutorial
960130
M9610810

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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