The role of IL-12 in the induction of organ-specific autoimmune diseases. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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The role of IL-12 in the induction of organ-specific autoimmune diseases.

Immunol Today. 1995 Aug;16(8):383-6. Unique Identifier : AIDSLINE MED/96002283
Trembleau S; Germann T; Gately MK; Adorini L; Roche Milano Ricerche, Italy.

Abstract: The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of several organ-specific autoimmune diseases, whereas Th2 cells inhibit disease development. Here, Sylvie Trembleau and colleagues examine the role of interleukin 12 (IL-12), a key cytokine guiding the development of Th1 cells, in the induction of autoimmune diseases, and discuss potential immunointervention strategies based on administration of IL-12 antagonists.
Keywords: Animal Antibodies, Monoclonal/IMMUNOLOGY/PHARMACOLOGY/THERAPEUTIC USE Arthritis/CHEMICALLY INDUCED/IMMUNOLOGY Autoimmune Diseases/CHEMICALLY INDUCED/DRUG THERAPY/*IMMUNOLOGY Collagen/TOXICITY Diabetes Mellitus, Insulin-Dependent/CHEMICALLY INDUCED/ IMMUNOLOGY Drug Design Encephalomyelitis, Allergic/IMMUNOLOGY/THERAPY Female Immunosuppressive Agents/PHARMACOLOGY/THERAPEUTIC USE Immunotherapy, Adoptive Interleukin-12/ANTAGONISTS & INHIB/*PHYSIOLOGY/TOXICITY Mice Mice, Inbred BALB C Mice, Inbred NOD Models, Immunological Organ Specificity/*IMMUNOLOGY Th1 Cells/*IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalantibodies,monoclonal/immunology/pharmacology/therapeuticusearthritis/chemicallyinduced/immunologyautoimmunediseases/chemicallyinduced/drugtherapy/
960130
M9610809

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