T helper cell differentiation in immune response.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

T helper cell differentiation in immune response.

Curr Opin Immunol. 1995 Jun;7(3):360-6. Unique Identifier : AIDSLINE MED/96057965
Reiner SL; Seder RA; Gwenn Knapp Center for Lupus and Immunology Research, Department; of Medicine, University of Chicago, IL 60637-5420, USA.

Abstract: Significant progress has been made in understanding the maturation of antigen-specific CD4+ T helper cell responses. Recent progress centers on the network of cytokines, accessory molecules, and cell types that shapes the differentiation of distinct T helper cell subsets. Use of transgenic and knockout mice and well characterized in vivo models have helped clarify the interdependence or independence of many of these complex factors.

Keywords: Animal Cell Differentiation/GENETICS Cytokines/IMMUNOLOGY Gene Expression Interferon Type II/IMMUNOLOGY Interleukin-2/IMMUNOLOGY Lymphocyte Transformation/GENETICS Mice Mice, Inbred BALB C Mice, Knockout Mice, Transgenic Models, Immunological Polymorphism (Genetics) Signal Transduction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Helper-Inducer/CYTOLOGY/*IMMUNOLOGY Th1 Cells/IMMUNOLOGY Th2 Cells/IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

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