Activation-induced death of mature T cells in the regulation of immune responses. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Activation-induced death of mature T cells in the regulation of immune responses.

Curr Opin Immunol. 1995 Jun;7(3):382-8. Unique Identifier : AIDSLINE MED/96057968
Russell JH; Department of Molecular Biology and Pharmacology, Washington; University School of Medicine, St Louis, MO 63110, USA.

Abstract: Deletion of self-reactive clones of immature thymocytes by activation-induced death (AID) is thought to be the primary mechanism for the establishment of self-tolerance in the T-cell compartment. Recent evidence suggests that a genetically distinct but analogous process of AID in mature T cells is important in regulating peripheral immune responses. AID of peripheral T cells requires the expression of functional Fas and Fas ligand by the T-cell population. As qualitatively similar signals from the TCR are responsible for both T-cell expansion in inflammation and T-cell elimination by AID, regulating the balance between these opposing functions plays a crucial role in successful responses to pathogens and tumors while minimizing autoimmunity.
Keywords: Animal Antigen Presentation/IMMUNOLOGY/PHYSIOLOGY Antigens, CD28/IMMUNOLOGY/PHYSIOLOGY Antigens, CD95/IMMUNOLOGY/PHYSIOLOGY *Apoptosis Cytokines/IMMUNOLOGY/PHYSIOLOGY Cytotoxicity, Immunologic Ligands *Lymphocyte Transformation Mice Mice, Inbred Strains Models, Immunological T-Lymphocytes/*IMMUNOLOGY/PHYSIOLOGY Th1 Cells/IMMUNOLOGY/PHYSIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalantigenpresentation/immunology/physiologyantigens,cd28/immunology/physiologyantigens,cd95/immunology/physiologyKWDapoptosiscytokines/immunology/physiologycytotoxicity,immunologicligandsKWDlymphocytetransformationmicemice,inbredstrainsmodels,immunologicalt-lymphocytes/KWDimmunology/physiologyth1cells/immunology/physiologyjournalarticlereviewreview,tutorial
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M9610798

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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