Progress in anti-HIV structure-based drug design. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Progress in anti-HIV structure-based drug design.

Trends Biotechnol. 1995 Oct;13(10):430-8. Unique Identifier : AIDSLINE MED/96030281
Gait MJ; Karn J; MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract: The course of drug development for the treatment of HIV-1 infection and AIDS is being revolutionized by high-resolution structures of essential viral proteins. We survey the impact on drug design of the recently elucidated structural knowledge of two essential enzymes, reverse transcriptase and protease, and three new targets, the viral integrase and the gene regulatory protein-RNA interactions, Tat-TAR and Rev-RRE.
Keywords: Antiviral Agents/*PHARMACOLOGY *Drug Design Drug Resistance DNA Nucleotidyltransferases/ANTAGONISTS & INHIB Human HIV/*DRUG EFFECTS/GENETICS HIV Protease Inhibitors/PHARMACOLOGY Reverse Transcriptase Inhibitors/PHARMACOLOGY Virus Replication/DRUG EFFECTS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDantiviralagents/KWDpharmacologyKWDdrugdesigndrugresistancednanucleotidyltransferases/antagonists&inhibhumanhiv/KWDdrugeffects/geneticshivproteaseinhibitors/pharmacologyreversetranscriptaseinhibitors/pharmacologyvirusreplication/drugeffectsjournalarticlereviewreview,tutorial
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M9610766

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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