Susceptibility of human monocytes to HIV type 1 infection in vitro is not dependent on their level of CD4 expression. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Susceptibility of human monocytes to HIV type 1 infection in vitro is not dependent on their level of CD4 expression.

AIDS Res Hum Retroviruses. 1995 Jul;11(7):769-76. Unique Identifier : AIDSLINE MED/96053838
Sonza S; Maerz A; Uren S; Violo A; Hunter S; Boyle W; Crowe S; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.

Abstract: Monocytes from HIV-seronegative persons were analyzed for CD4 expression and susceptibility to infection with HIV-1 on the day of isolation and following 1, 2, and 7 days in culture. Although surface CD4 was readily detected on freshly isolated monocytes, these cells were relatively resistant to infection. After 1 to 2 days in culture, when surface expression of CD4 had decreased over 90% to near background levels, cells became susceptible to infection with HIV-1. CD4 expression on monocytes cultured for 7 days was more than four times higher than that on freshly isolated cells, and the cultured cells were fully permissive to infection. These observations suggest that the differing susceptibility of monocytes and monocyte-derived macrophages to infection with HIV-1 is not simply proportional to the level of surface CD4 expression.
Keywords: Antigens, CD/BIOSYNTHESIS/PHYSIOLOGY Antigens, CD4/BIOSYNTHESIS/*PHYSIOLOGY Cells, Cultured Flow Cytometry Human HIV Seronegativity/IMMUNOLOGY HIV-1/*PHYSIOLOGY/PATHOGENICITY Kinetics Lipopolysaccharides/PHARMACOLOGY Lymphocytes/*IMMUNOLOGY/*VIROLOGY Macrophages/IMMUNOLOGY/VIROLOGY Monocytes/DRUG EFFECTS/*IMMUNOLOGY/*VIROLOGY Support, Non-U.S. Gov't Time Factors JOURNAL ARTICLE

KWDantigens,cd/biosynthesis/physiologyantigens,cd4/biosynthesis/KWDphysiologycells,culturedflowcytometryhumanhivseronegativity/immunologyhiv-1/KWDphysiology/pathogenicitykineticslipopolysaccharides/pharmacologylymphocytes/KWDimmunology/KWDvirologymacrophages/immunology/virologymonocytes/drugeffects/KWDimmunology/KWDvirologysupport,non-uKWDsKWDgov'ttimefactorsjournalarticle
960130
M9610760

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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