Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma.

AIDS Res Hum Retroviruses. 1995 Jul;11(7):823-7. Unique Identifier : AIDSLINE MED/96053845
Zehender G; Meroni L; Piconi S; De Maddalena C; Parravicini C; Clerici M; Ridolfo AL; Moroni M; Galli M; Clinica delle Malattie Infettive, University of Milan, Italy.

Abstract: We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3%-p = 0.0027). One of the HIV-1-positive and none of the HIV-1-negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-II or a closely homologous retrovirus infects a high proportion of patients with AIDS-associated NHL.
Keywords: Adult Blotting, Western DNA, Viral/ANALYSIS Enzyme-Linked Immunosorbent Assay Female Human HTLV-I Antibodies/*BLOOD HTLV-I Antigens/IMMUNOLOGY HTLV-II/GENETICS/ISOLATION & PURIF HTLV-II Antibodies/*BLOOD HTLV-II Antigens/IMMUNOLOGY Lymphoma, AIDS-Related/BLOOD/*IMMUNOLOGY/PATHOLOGY/*VIROLOGY Male Middle Age Polymerase Chain Reaction Retrospective Studies Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadultblotting,westerndna,viral/analysisenzyme-linkedimmunosorbentassayfemalehumanhtlv-iantibodies/KWDbloodhtlv-iantigens/immunologyhtlv-ii/genetics/isolation&purifhtlv-iiantibodies/KWDbloodhtlv-iiantigens/immunologylymphoma,aids-related/blood/KWDimmunology/pathology/KWDvirologymalemiddleagepolymerasechainreactionretrospectivestudiessupport,non-uKWDsKWDgov'tjournalarticle
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M9610753

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