Chancroid and Haemophilus ducreyi: an update. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Chancroid and Haemophilus ducreyi: an update.

Clin Microbiol Rev. 1995 Jul;8(3):357-75. Unique Identifier : AIDSLINE MED/96009213
Trees DL; Morse SA; Division of Sexually Transmitted Disease, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.

Abstract: Haemophilus ducreyi is a fastidious gram-negative bacillus that causes the sexually transmitted infection chancroid. Chancroid is a major genital ulcerative disease in Africa, Southeast Asia, the Caribbean, and Latin America and is of increasing concern in the United States. Genital ulcerative disease and chancroid in particular have been associated with facilitating the transmission of human immunodeficiency virus. The diagnosis of chancroid based on the clinical appearance of the genital lesion or on the isolation of H. ducreyi on selective medium is relatively insensitive. However, recent advances in nonculture diagnostic tests have enhanced our ability to diagnose chancroid. There has been renewed interest in understanding the pathogenesis of H. ducreyi. In vitro and in vivo models have been developed to help identify important virulence determinants. Through the use of biochemical and molecular techniques, macromolecular components that may be important in virulence have been identified.
Keywords: Animal Antibody Formation Bacterial Typing Techniques Chancroid/*DIAGNOSIS/DRUG THERAPY/EPIDEMIOLOGY/*MICROBIOLOGY Culture Media/CHEMISTRY Forecasting Haemophilus ducreyi/*CLASSIFICATION/DRUG EFFECTS/GROWTH & DEVELOPMENT/*PATHOGENICITY Human Microbial Sensitivity Tests Virulence JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalantibodyformationbacterialtypingtechniqueschancroid/KWDdiagnosis/drugtherapy/epidemiology/KWDmicrobiologyculturemedia/chemistryforecastinghaemophilusducreyi/KWDclassification/drugeffects/growth&development/KWDpathogenicityhumanmicrobialsensitivitytestsvirulencejournalarticlereviewreview,tutorial
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M9610546

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