Micronutrient levels in HIV-1-infected children.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Micronutrient levels in HIV-1-infected children.

AIDS. 1995 Aug;9(8):887-93. Unique Identifier : AIDSLINE MED/96014962
Periquet BA; Jammes NM; Lambert WE; Tricoire J; Moussa MM; Garcia J; Ghisolfi J; Thouvenot J; Purpan Hospital, Toulouse, France.

Abstract: OBJECTIVE: Micronutrients (zinc, copper, selenium, vitamin A, E, and carotenoids) are essential for the integrity of host defences. This study was designed to determine the prevalence of abnormalities of the micronutrient levels in HIV-1-seropositive children. DESIGN: Prospective study. SETTING: The study was performed on HIV-1-infected children at the Paediatric Haematology and Oncology Unit of Toulouse Hospital, France. PATIENTS: Twenty-one children, suffering from HIV-1 infection and 21 control subjects of similar age (2-9 years) were included in the study. In the HIV-1-infected children, two subgroups were considered according to stage (non-AIDS or AIDS), based on the Centers for Disease Control and Prevention 1987 criteria. RESULTS: The first statistically significant deficiencies occurred at non-AIDS stage and were confirmed at AIDS stage: P < 0.05 for lycopene, retinol, tocopherol and P < 0.001 for transthyretin and serum albumin. Levels of copper (40%) and long-chain polyunsaturated fatty acids (21%) were higher in the non-AIDS group than the controls. CONCLUSION: Biological impairing of the micronutrient levels was observed in the non-AIDS stage without clinical sign. This information is useful in delineating eventual and well considered nutritional intervention strategies that may improve the clinical status of HIV-1-infected children and perhaps alter the course of their disease.

Keywords: Carotene/BLOOD/DEFICIENCY Case-Control Studies Child Child, Preschool Copper/BLOOD Erythrocytes/METABOLISM Fatty Acids, Unsaturated/BLOOD Female Human HIV Infections/*BLOOD/CLASSIFICATION/COMPLICATIONS *HIV-1 Male Micronutrients/*METABOLISM Nutritional Status Prealbumin/DEFICIENCY/METABOLISM Prospective Studies Serum Albumin/DEFICIENCY Support, Non-U.S. Gov't Vitamin A/BLOOD Vitamin A Deficiency/BLOOD/COMPLICATIONS Vitamin E/BLOOD Vitamin E Deficiency/BLOOD/COMPLICATIONS JOURNAL ARTICLE
960228
M9621067

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