Beta 2-microglobulin expression of AIDS-related and classical Kaposi's sarcoma. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Beta 2-microglobulin expression of AIDS-related and classical Kaposi's sarcoma.

APMIS. 1995 Jul-Aug;103(7-8):553-7. Unique Identifier : AIDSLINE MED/96033961
Petersen BL; Petersen CL; Jensen A; Thomsen HK; Werdelin O; Braendstrup O; Department of Pathology, Glostrup Hospital, Denmark.

Abstract: The expression of beta 2-microglobulin, the invariable light chain of HLA class I molecules, of Kaposi's sarcoma from 11 AIDS patients and from 11 patients without known immunodeficiency was studied by immunohistochemistry using a polyclonal antibody to beta 2-microglobulin. The staining intensity of spindle cells in these lesions was scored in a semiquantitative system. We found that the spindle cells of Kaposi's sarcomas from AIDS patients showed significantly increased staining intensity for beta 2-microglobulin compared to those of Kaposi's sarcomas from non-AIDS patients. The results may indicate that Kaposi's sarcomas developing in immunocompromised individuals, such as AIDS patients, are not subject to immune selection by T cells eliminating HLA class I high-expressing tumor cells, while this may be the case in non-AIDS patients. Alternatively, the results may be caused by differences in the activity of cytokines, which upregulate the expression of HLA class I molecules on the cell surface.
Keywords: beta 2-Microglobulin/*BIOSYNTHESIS Acquired Immunodeficiency Syndrome/COMPLICATIONS/*METABOLISM/ PATHOLOGY Adult Aged Aged, 80 and over Female Human Male Middle Age Sarcoma, Kaposi's/COMPLICATIONS/*METABOLISM/PATHOLOGY Skin Neoplasms/COMPLICATIONS/*METABOLISM/PATHOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLEKWDbeta2-microglobulin/KWDbiosynthesisacquiredimmunodeficiencysyndrome/complications/KWDmetabolism/pathologyadultagedaged,80andoverfemalehumanmalemiddleagesarcoma,kaposi's/complications/KWDmetabolism/pathologyskinneoplasms/complications/KWDmetabolism/pathologysupport,non-uKWDsKWDgov'tjournalarticle
960228
M9621044

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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