Intrapatient variability of the human immunodeficiency virus type 2 envelope V3 loop. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Intrapatient variability of the human immunodeficiency virus type 2 envelope V3 loop.

AIDS Res Hum Retroviruses. 1995 May;11(5):617-23. Unique Identifier : AIDSLINE GENBANK/U24388
Sankale JL; de la Tour RS; Renjifo B; Siby T; Mboup S; Marlink RG; Essex ME; Kanki PJ; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.

Abstract: Studies of HIV-2 infection have shown lower rates of sexual and perinatal transmission and a prolonged incubation period to AIDS as compared to HIV-1. To evaluate the role of genetic variation in HIV pathogenesis, we studied intrapatient variability in the V3 loop of the HIV-2 envelope gene over time in five seropositive individuals. Proviral sequences derived from uncultured PBMC DNA (n = 102) demonstrated an average sequence heterogeneity within a sample of 1.4% (0-4.1%). This was significantly lower than the V3 sequence heterogeneity observed in HIV-1, which can be as high as 6.1%. In HIV-2-seropositive healthy patients the average intrapatient nucleotide variability rate was 0.6% compared to 2.0% in patients with clinical AIDS. The lower rate of variability between HIV-2 and HIV-1 is compatible with differences in transmission and pathogenesis of these two related viruses.
Keywords: Amino Acid Sequence Base Sequence CD4 Lymphocyte Count DNA Primers Female Follow-Up Studies Human HIV Envelope Protein gp120/*GENETICS HIV Infections/BLOOD/PHYSIOPATHOLOGY/*VIROLOGY HIV-1/GENETICS HIV-2/*GENETICS/ISOLATION & PURIF Male Molecular Sequence Data Peptide Fragments/*GENETICS Polymerase Chain Reaction Sequence Homology, Amino Acid Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. *Variation (Genetics) JOURNAL ARTICLEKWDaminoacidsequencebasesequencecd4lymphocytecountdnaprimersfemalefollow-upstudieshumanhivenvelopeproteingp120/KWDgeneticshivinfections/blood/physiopathology/KWDvirologyhiv-1/geneticshiv-2/KWDgenetics/isolation&purifmalemolecularsequencedatapeptidefragments/KWDgeneticspolymerasechainreactionsequencehomology,aminoacidsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDs
960228
M9621031

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .