Defective natural killer cell cytotoxic activity in feline immunodeficiency virus-infected cats. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Defective natural killer cell cytotoxic activity in feline immunodeficiency virus-infected cats.

AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. Unique Identifier : AIDSLINE MED/96078236
Zaccaro L; Falcone ML; Silva S; Bigalli L; Cecchettini A; Giorgi F; Malvaldi G; Bendinelli M; Centro Retrovirus, Universita di Pisa, Italy.

Abstract: Flow cytometry has been employed to study NK cell cytotoxic activity in cats infected with feline immunodeficiency virus. The results show that animals infected for 12 months or more have decreased levels of NK cell cytotoxic activity in their blood. The impairment could not be overcome by in vitro treatment of effector cells with interleukin 2. Additional results suggest that the NK cells of infected cats are defective, in that they are still able to bind to target cells but have a reduced ability to kill them.
Keywords: Animal Cats Cytotoxicity Tests, Immunologic/METHODS *Cytotoxicity, Immunologic CD4-CD8 Ratio Immunodeficiency Virus, Feline/*IMMUNOLOGY Interleukin-2/PHARMACOLOGY Killer Cells, Natural/*IMMUNOLOGY Lentivirus Infections/*IMMUNOLOGY Leukocytes, Mononuclear/DRUG EFFECTS Matched-Pair Analysis Specific Pathogen-Free Organisms Support, Non-U.S. Gov't JOURNAL ARTICLEKWDanimalcatscytotoxicitytests,immunologic/methodsKWDcytotoxicity,immunologiccd4-cd8ratioimmunodeficiencyvirus,feline/KWDimmunologyinterleukin-2/pharmacologykillercells,natural/KWDimmunologylentivirusinfections/KWDimmunologyleukocytes,mononuclear/drugeffectsmatched-pairanalysisspecificpathogen-freeorganismssupport,non-uKWDsKWDgov'tjournalarticle
960228
M9621014

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .