1996

HIV+/AIDS : the facts and the future. [videorecording]: St. Louis : Mosby-Year Book, c1995 3 videocassettes : sd., col. ; 1/2 in. + 3 manuals Unique Identifier : AIDSLINE AV/9516089; Scherr SK
Prevention and management for the exposed healthcare provider. [videorecording]: Rosemont, Ill. : American Association of Oral and Maxilliofacial Surgeons, c1993 1 videocassette (45 min.) : sd., col. ; 1/2 in (Video continuing education series ; A300V) Unique Identifier : AIDSLINE AV/9505101; Myall RW
The:family and HIV.: London ; New York, NY : Cassell, 1994 xviii, 282 p. : ill Unique Identifier : AIDSLINE CAT/9510648; Bor R; Elford J
AIDS : a guide to the law. 2nd ed.: London ; New York : Routledge, 1995 xii, 185 p Unique Identifier : AIDSLINE CAT/9515016; Haigh R; Harris D
Evaluation of a national AIDS programme : a methods package.: Geneva : World Health Organization, 1994- v. : ill Unique Identifier : AIDSLINE CAT/9506995
Handbook for HIV prevention community planning.: Washington, D.C. : Academy for Educational Development, [1994] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9515225
HIV and dementia : proceedings of the NIMH-sponsored conference Pathogenesis of HIV infection of the brain: impact on function and behavior.: Berlin ; New York : Springer, c1995 xii, 279 p. : ill (Current topics in microbiology and immunology, ISSN 0070-217X ; 202) Unique Identifier : AIDSLINE CAT/9516647; Oldstone MB; Vitkovic L
Planning and evaluating HIV/AIDS prevention programs in state and local health departments : a companion to program announcement #300.: [Washington, D.C.?] : U.S. Dept. of Health & Human Services, Public Health Service, Centers for Disease Control and Prevention, [1993] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9515428; Schechter C
The:search for an AIDS vaccine : ethical issues in the development and testing of a preventive HIV vaccine.: Bloomington : Indiana University Press, c1995 193 p (Medical ethics series) Unique Identifier : AIDSLINE CAT/9514771; Grady C
Adverse reactions to HIV vaccines : medical, ethical, and legal issues.: Washington, D.C. : Congress of the United States, Office of Technology Assessment : For sale by the U.S. G.P.O., Supt. of Docs., [1995] viii, 197 p. : ill (HIV-related issues. Background paper ; 11) Unique Identifier : AIDSLINE CAT/9517756
Directory of socio-behavioural research on HIV infection and AIDS in Zimbabwe. 1st ed.: Harare : Blair Research Institute, [1992] 100 p Unique Identifier : AIDSLINE CAT/9516389
HIV care : a comprehensive handbook for providers.: Thousand Oaks, Calif. : Sage Publications, c1995 xxviii, 220 p Unique Identifier : AIDSLINE CAT/9514851; Andrews LJ; Novick LB
In the shadow of the epidemic : being HIV-negative in the age of AIDS.: Durham : Duke University Press, 1995 x, 314 p (Series Q) Unique Identifier : AIDSLINE CAT/9515573; Odets W
[La:personne toxicomane VIH-SIDA et le stress induit chez l'intervenant : compte-rendu de la rencontre des equipes des UHRESS du 21 avril 1993.]: Montreal, Quebec : Gouvernement du Quebec, Ministere de la sante et des services sociaux, Centre quebecois de coordination sur le SIDA, [1993?] 106 p. : ill Unique Identifier : AIDSLINE CAT/9514975
[Le:sida et la societe francaise : rapport au Premier Ministre.]: Paris : La documentation francaise, 1994 324 p. : ill (Collection des rapports officiels, ISSN 0981-3764) Unique Identifier : AIDSLINE CAT/9431098; Montagnier L
AIDS analysis Asia.: London : AIDS Analysis Ltd., v. : ill Unique Identifier : AIDSLINE CAT/9600618
[AIDS = SIDA.] [2. ed.].: Sao Paulo, Brasil : Sarvier, 1990 302 p. : ill Unique Identifier : AIDSLINE CAT/9406371; Lacaz Cd
AIDS, sex, and family planning : a Christian view.: Achimota, Ghana : Africa Christian Press, 1989 92 p. : ill Unique Identifier : AIDSLINE CAT/9512376; Baker K
HIV/AIDS work group on health care access issues for gay and bisexual men of color.: Color [Rockville, Md.] : U.S. Dept. of Health & Human Services, Public Health Service, Health Resources and Services Administration, Bureau of Health Resources Development, [1995?] 55 p (DHHS publication ; no. HRSA 95-4) Unique Identifier : AIDSLINE CAT/9514618
[Pathologie infectieuse et demarche de soins.]: Thoiry : Editions heures de France, c1993 2 v. : ill Unique Identifier : AIDSLINE CAT/9423420; Pebret F
[Rapi Zappeur presente toxico, sida & co.]: [Cherbourg] : Isoete, c1994 55 p. : ill Unique Identifier : AIDSLINE CAT/9430640; Bartier
[Rapport d'activites du programme a moyen terme : juillet 90-janvier 1991.]: Moroni : Le Programme, [1991?] 17 leaves : ill Unique Identifier : AIDSLINE CAT/9515291
[Therapeutique pratique de l'infection par le virus de l'immunodeficience humaine.]: Paris : Med-Line [1993] 176 p. : ill Unique Identifier : AIDSLINE CAT/9430704; Belec L
Exposure to blood and body fluid: factors associated with non-compliance in follow up HIV testing among health care workers.: AAOHN J. 1995 Oct;43(10):507-13. Unique Identifier : AIDSLINE MED/96077846; Sass J; Bertolone K; Denton D; Logsdon MC; Due to lack of previous research, this study examined the factors associated with non-compliance in follow up human immunodeficiency virus (HIV) testing among health care workers after blood and/or body fluid exposure. A descriptive correlation design was used with 178 health care workers who did not return for recomm
Lack of requirement for CD8+ cells in recovery from and resistance to experimental autoimmune encephalomyelitis.: J Autoimmun. 1995 Jun;8(3):395-404. Unique Identifier : AIDSLINE MED/96082299; Lohse AW; Schwerdt A; Herkel J; Spahn T; Meyer zum Buschenfelde KH; Department of Medicine, Johannes Gutenberg-University, Mainz,; Germany.; Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell mediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4+ T-cells, whose adoptive transfer can also induce passive disease. In the Lewis rat EAE is a transient disease inducing lasting resistance to rechallenge. Th
Enhancement of CTL response induced by a viral peptide using cationized BSA, a Th1-stimulating adjuvant.: Viral Immunol. 1994;7(4):179-88. Unique Identifier : AIDSLINE MED/96100712; Vasilakos JP; Michael JG; Department of Molecular Genetics, Biochemistry, and Microbiology,; University of Cincinnati, Ohio 45267-0524, USA.; We have recently shown that it is possible to activate cytotoxic T cells (CTL) in vivo with HSV-1 glycoprotein B H-2Kb-restricted peptide (gB peptide) independent of CD4+ T cell help. Here we report that the gB peptide-specific CTL response is significantly enhanced when mice are immunized with a mixture of gB peptide
Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a noncovalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response.: Viral Immunol. 1994;7(4):189-97. Unique Identifier : AIDSLINE MED/96100713; Nehete PN; Arlinghaus RB; Sastry KJ; Department of Veterinary Sciences, University of Texas M.D.; Anderson Cancer Center, Bastrop 78602, USA.; Our previous reports established that immunization of mice in the footpad with a 15-amino acid synthetic peptide (R15K) from the V3 loop region in the envelope protein gp120 of human immunodeficiency virus type 1 (HIV-1) resulted in rapid induction of major histocompatability complex (MHC) class I-restricted, CD8+ HIV
Serum reactivity against an immunoregulatory sequence of HIV p24 in HIV-1-infected subjects.: Viral Immunol. 1994;7(4):199-203. Unique Identifier : AIDSLINE MED/96100714; Cordiali Fei P; Solmone M; Prignano G; Pugliese O; Viora M; Luzzati A; Ameglio F; Laboratory of Clinical Pathology, Istituto San Gallicano, Rome,; Italy.; The aim of this study was to assess the antibody reactivity in HIV-infected subjects against an HIV-1 p24 sequence, p226 (aa226-237), including a seven amino acid epitope showing immunosuppressive activity in vitro and to evaluate the relationship between anti-peptide antibody levels and disease progression. Sera of H
Immunoglobulin-like domain of HIV-1 envelope glycoprotein gp120 encodes putative internal image of some common human proteins.: Viral Immunol. 1994;7(4):215-9. Unique Identifier : AIDSLINE MED/96100716; Metlas R; Skerl V; Veljkovic V; Colombatti A; Pongor S; Laboratory for Multidisciplinary Research, Institute for Nuclear; Sciences Vinca, Belgrade, Yugoslavia.; By examining sequence similarity between the V3-loop of gp120 from various HIV-1 isolates and human proteins, we found that the V3 loop portion KKGIAIGPGR in strain New York 5 (HIV-1NY5) shares 70% identical residues with the collagen-like region (CLR) of human complement component C1q-A. C1q CLR was found to react wi
Cellular immune responses of macaques exposed to low doses of SIV [letter]: Immunol Today. 1995 Oct;16(10):501. Unique Identifier : AIDSLINE MED/96045907; Dittmer U; Spring M; Bodemer W; Hunsmann G
Special issue: The 9th International Congress of Immunology. San Francisco, California, 23-29 July 1995.: Immunol Today. 1995 Jul;16(7):305-62. Unique Identifier : AIDSLINE MED/96080657
The immune response to HIV: potential for immunotherapy?: Immunol Today. 1995 Jul;16(7):356-8. Unique Identifier : AIDSLINE MED/96080674; Dalgleish AG; Dept of Cellular and Molecular Sciences, St George's Hospital; Medical School, London, UK.
Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy.: Am J Reprod Immunol. 1995 May;33(5):394-404. Unique Identifier : AIDSLINE MED/96070201; Rukavina D; Rubesa G; Gudelj L; Haller H; Podack ER; Department of Physiology and Immunology, Medical Faculty,; University of Rijeka, Croatia.; PROBLEM: The number of perforin (P)-positive cells in decidua of pregnancy is larger than that observed in any other pathological condition. The aim was to investigate the distribution and the phenotype of P+ cells. METHOD: Decidual tissue was obtained from the first trimester vaginal termination of pregnancy. Tissue
AIDS behind bars: preventing HIV spread among incarcerated drug injectors [editorial]: AIDS. 1995 Aug;9(8):825-32. Unique Identifier : AIDSLINE MED/96014954; Dolan K; Wodak A; Penny R
Encapsulation of foscarnet in liposomes modifies drug intracellular accumulation, in vitro anti-HIV-1 activity, tissue distribution and pharmacokinetics.: AIDS. 1995 Aug;9(8):833-41. Unique Identifier : AIDSLINE MED/96014955; Dusserre N; Lessard C; Paquette N; Perron S; Poulin L; Tremblay M; Beauchamp D; Desormeaux A; Bergeron MG; Centre de Recherche en Infectiologie, Centre Hospitalier de; I'Universite Laval, Ste-Foy, Quebec, Canada.; OBJECTIVE: To improve the in vitro anti-HIV-1 activity, intracellular accumulation in macrophages and in vivo pharmacokinetics and tissue distribution of foscarnet (trisodium phosphonoformate; PFA) by encapsulation in liposomes. METHODS: The accumulation of free and liposome-encapsulated PFA was determined in monocyte
Determination of HIV-1 subtypes in injecting drug users in Bangkok, Thailand, using peptide-binding enzyme immunoassay and heteroduplex mobility assay: evidence of increasing infection with HIV-1 subtype E.: AIDS. 1995 Aug;9(8):843-9. Unique Identifier : AIDSLINE MED/96014956; Wasi C; Herring B; Raktham S; Vanichseni S; Mastro TD; Young NL; Rubsamen-Waigmann H; von Briesen H; Kalish ML; Luo CC; et al; Department of Microbiology, Faculty of Medicine, Siriraj; Hospital, Mahidol University, Bangkok, Thailand.; OBJECTIVES: To evaluate the sensitivity and specificity of peptide-binding enzyme immunoassay (PEIA) and heteroduplex mobility assay (HMA) for the determination of HIV-1 subtypes B and E; to determine the proportions of infections due to subtypes B and E over time; and to generate data on DNA sequences of the C2-V3 re
The evolving molecular epidemiology of HIV-1 envelope subtypes in injecting drug users in Bangkok, Thailand: implications for HIV vaccine trials.: AIDS. 1995 Aug;9(8):851-7. Unique Identifier : AIDSLINE MED/96014957; Kalish ML; Baldwin A; Raktham S; Wasi C; Luo CC; Schochetman G; Mastro TD; Young N; Vanichseni S; Rubsamen-Waigmann H; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; OBJECTIVE: To genetically characterize HIV-1 strains in injecting drug users (IDU) in Bangkok, Thailand in 1994, and compare these with strains found earlier in Thai IDU; such information is essential for HIV-1 vaccine development and evaluation. METHODS: Peripheral blood mononuc
Productive HIV-1 infection of normal human mammary epithelial cells.: AIDS. 1995 Aug;9(8):859-66. Unique Identifier : AIDSLINE MED/96014958; Toniolo A; Serra C; Conaldi PG; Basolo F; Falcone V; Dolei A; Institute of Medicine and Public Health, University of Pavia,; Varese, Italy.; OBJECTIVE AND DESIGN: To determine the susceptibility of mammary epithelial cells (MEC) to HIV-1 as breastfeeding is an established route of HIV transmission, although the origin of virus in breastmilk is unclear. METHODS: Primary epithelial cell cultures were derived from the mammary glands of healthy donors; immorta
Neutralization of primary HIV-1 isolates by anti-envelope monoclonal antibodies.: AIDS. 1995 Aug;9(8):867-74. Unique Identifier : AIDSLINE MED/96014959; D'Souza MP; Milman G; Bradac JA; McPhee D; Hanson CV; Hendry RM; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; OBJECTIVE: To evaluate human monoclonal antibodies (MAb) for neutralizing activity against primary HIV-1 isolates in peripheral blood mononuclear cells. DESIGN: Neutralization activity data were obtained from 11 laboratories on a coded panel consisting of six human MAb to HIV envelope V3, CD4-binding region or gp41. H
Diagnosis and prognosis of AIDS-related cholangitis.: AIDS. 1995 Aug;9(8):875-80. Unique Identifier : AIDSLINE MED/96014960; Ducreux M; Buffet C; Lamy P; Beaugerie L; Fritsch J; Choury A; Liguory C; Longuet P; Gendre JP; Vachon F; et al; Department of Hepato-Gastroenterology, Bicetre Hospital, Le; Kremlin Bicetre, France.; OBJECTIVE: To determine more precisely the clinical and biological characteristics of AIDS-related cholangitis, and to investigate prognostic variables of this disease. DESIGN: Retrospective clinical and prognostic study. SETTING: Biliary unit, Bicetre Hospital, France . PATIENTS: H
Campylobacter infections in HIV-infected patients: clinical and bacteriological features.: AIDS. 1995 Aug;9(8):881-5. Unique Identifier : AIDSLINE MED/96014961; Molina J; Casin I; Hausfater P; Giretti E; Welker Y; Decazes J; Garrait V; Lagrange P; Modai J; Infectious Disease Department, Saint-Louis Hospital, Paris,; France.; OBJECTIVE: To study the clinical and bacteriological features of Campylobacter infections in HIV-infected patients. DESIGN: A retrospective analysis (1989-1992), followed by a prospective analysis (1992-1994). SETTING: Hospital HIV inpatient unit. PATIENTS AND METHODS: All patients with Campylobacter spp. identified b
Micronutrient levels in HIV-1-infected children.: AIDS. 1995 Aug;9(8):887-93. Unique Identifier : AIDSLINE MED/96014962; Periquet BA; Jammes NM; Lambert WE; Tricoire J; Moussa MM; Garcia J; Ghisolfi J; Thouvenot J; Purpan Hospital, Toulouse, France.; OBJECTIVE: Micronutrients (zinc, copper, selenium, vitamin A, E, and carotenoids) are essential for the integrity of host defences. This study was designed to determine the prevalence of abnormalities of the micronutrient levels in HIV-1-seropositive children. DESIGN: Prospective study. SETTING: The study was performe
Nested polymerase chain reaction for diagnosis and monitoring treatment response in AIDS patients with tuberculous meningitis.: AIDS. 1995 Aug;9(8):895-900. Unique Identifier : AIDSLINE MED/96014963; Scarpellini P; Racca S; Cinque P; Delfanti F; Gianotti N; Terreni MR; Vago L; Lazzarin A; Infectious Diseases Department, San Raffaele Scientific; Institute, Milan, Italy.; OBJECTIVE: To investigate the usefulness of polymerase chain reaction (PCR) from cerebrospinal fluid (CSF) for rapid diagnosis and assessing treatment response of tuberculous meningitis (TBM) in AIDS patients. PATIENTS: Forty-four CSF samples from 10 patients with TBM confirmed by autopsy or by a culture of CSF (41 sa
Effects of aerosolized pentamidine on glucose homeostasis and insulin secretion in HIV-positive patients: a controlled study.: AIDS. 1995 Aug;9(8):901-7. Unique Identifier : AIDSLINE MED/96014964; Uzzan B; Bentata M; Campos J; Mosnier A; Krivitzky A; Perret GY; Modigliani E; Department of Pharmacology-Hormonology, Avicenne Hospital, CHU; Paris-Nord, Bobigny, France.; OBJECTIVE: Intravenous pentamidine induces hypo- and hyperglycaemia (dose-dependent toxicity on islet beta cells), pancreatitis and nephrotoxicity. Conversely, aerosolized pentamidine (AP) is usually devoid of systemic side-effects: few reports of hypo- or hyperglycaemia have been published. Our study aimed to assess
HIV infection and invasive cervical carcinoma in an Italian population: the need for closer screening programmes in seropositive patients.: AIDS. 1995 Aug;9(8):909-12. Unique Identifier : AIDSLINE MED/96014965; Zanetta G; Maneo A; Colombo A; Ragusa A; Gabriele A; Placa F; Mangioni C; Department of Obstetrics and Gynaecology, S. Gerardo Hospital,; University of Milan, Monza, Italy.; OBJECTIVE: To evaluate in an Italian population the prevalence, characteristics at first diagnosis and outcome of HIV-seropositive individuals with cervical carcinoma referred to a tertiary-care institution. DESIGN: A retrospective evaluation of all patients referred for invasive cervical carcinoma from 1991 to 1994.
The incidence of complications after caesarean section in 156 HIV-positive women.: AIDS. 1995 Aug;9(8):913-7. Unique Identifier : AIDSLINE MED/96014966; Semprini AE; Castagna C; Ravizza M; Fiore S; Savasi V; Muggiasca ML; Grossi E; Guerra B; Tibaldi C; Scaravelli G; et al; Department of Obstetrics and Gynaecology, San Paolo Biomedical; Institute, Milan, Italy.; OBJECTIVE: To investigate the risks of post-operative complications in HIV-positive mothers who undergo a caesarean section (CS) because the delivery cannot be safely accomplished by the vaginal route or to protect the infant from viral infection. DESIGN: In a multicentre study, we reviewed the incidence and type of p
A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 1. Design.: AIDS. 1995 Aug;9(8):919-26. Unique Identifier : AIDSLINE MED/96014967; Hayes R; Mosha F; Nicoll A; Grosskurth H; Newell J; Todd J; Killewo J; Rugemalila J; Mabey D; London School of Hygiene and Tropical Medicine, UK.; OBJECTIVE: To describe the rationale and design of a randomized trial of the impact of improved services for the treatment of sexually transmitted diseases (STD) on the incidence of HIV infection in Mwanza Region, Tanzania . METHODS: The likely impact of improved STD treatment ser
A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 2. Baseline survey results.: AIDS. 1995 Aug;9(8):927-34. Unique Identifier : AIDSLINE MED/96014968; Grosskurth H; Mosha F; Todd J; Senkoro K; Newell J; Klokke A; Changalucha J; West B; Mayaud P; Gavyole A; et al; African Medical and Research Foundation, Mwanza, Tanzania.; OBJECTIVES: To determine baseline HIV prevalence in a trial of improved sexually transmitted disease (STD) treatment, and to investigate risk factors for HIV. To assess comparability of intervention and comparison communities with respect to HIV/STD prevalence and risk factors. To assess adequacy of sample size. SETTI
Couple communication, sexual coercion and HIV risk reduction in Kigali, Rwanda.: AIDS. 1995 Aug;9(8):935-44. Unique Identifier : AIDSLINE MED/96014969; van der Straten A; King R; Grinstead O; Serufilira A; Allen S; Center for AIDS Prevention Studies, University of California, San; Francisco, USA.; OBJECTIVE: To describe sexual interaction and HIV-related communication in Rwandan couples and to examine their relationship to HIV testing and condom use. STUDY DESIGN: Cross-sectional survey of a longitudinal cohort. METHODS: In 1988, women recruited for an epidemiological study of HIV, and interested male partners,
Use of pooling and outpatient laboratory specimens in an anonymous seroprevalence survey of HIV infection in British Columbia, Canada.: AIDS. 1995 Aug;9(8):945-50. Unique Identifier : AIDSLINE MED/96014970; Sherlock CH; Strathdee SA; Le T; Sutherland D; O'Shaughnessy MV; Schechter MT; Department of Pathology, University of British Columbia,; Vancouver, Canada.; OBJECTIVE: To conduct an anonymous HIV seroprevalence survey to establish a baseline estimate of HIV seroprevalence in a general population; to evaluate serum pooling and alternative testing strategies as cost-saving measures. DESIGN: Prospective anonymous HIV seroprevalence study using outpatient laboratory specimens
HIV status of female sex partners of men reactive to HIV-1, HIV-2 or both viruses in Abidjan, Cote d'Ivoire.: AIDS. 1995 Aug;9(8):951-4. Unique Identifier : AIDSLINE MED/96014971; N'Gbichi JM; De Cock KM; Batter V; Yeboue K; Ackah A; Zadi F; Diallo MO; Kadio A; Gayle HD; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVES: To compare rates of serologic concordance in the female sex partners of men with HIV-1 and HIV-2 infections, and to determine the serologic status of sex partners of men who reacted serologically to both viruses. DESIGN: Cross-sectional study. SETTING: Infectious diseases service in a University Hospital i
Dual seroreactivity to HIV-1 and HIV-2 in female sex workers in Abidjan, Cote d'Ivoire.: AIDS. 1995 Aug;9(8):955-8. Unique Identifier : AIDSLINE MED/96014972; Ghys PD; Diallo MO; Ettiegne-Traore V; Yeboue KM; Gnaore E; Lorougnon F; Teurquetil MJ; Adom ML; Greenberg AE; Laga M; et al; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVE: To determine the absolute and proportional prevalence of dual seroreactivity to HIV-1 and HIV-2 in female sex workers in Abidjan, to determine risk determinants for this serologic profile, and to describe the associated clinical and immunological characteristics. DESIGN: Cross-sectional study. SETTING: Conf
HIV risk behaviors but absence of infection among drug users in detoxification centers outside Yunnan province, China, 1993.: AIDS. 1995 Aug;9(8):959-63. Unique Identifier : AIDSLINE MED/96014973; Zheng X; Tian C; Zhang G; Li D; Liu X; Hu DJ; Weniger BG; Dondero TJ; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing, China.; OBJECTIVES: To date, HIV spread in China has occurred principally among injecting drug users (IDU) in remote border regions of Yunnan province. We therefore sought to better understand the risks for and prevalence of HIV infection among drug users in parts of China outside Yunnan pr
Decreasing prevalence hides a high HIV incidence: Miami.: AIDS. 1995 Aug;9(8):965-70. Unique Identifier : AIDSLINE MED/96014974; Peterman TA; Zaidi AA; Wroten J; Division of STD/HIV Prevention, Centers for Disease Control,; Atlanta, Georgia 30333, USA.; OBJECTIVE: Study methods of assessing HIV trends in sexually transmitted disease (STD) clinics where blinded seroprevalence has been among the highest in the United States . DESIGN: Cross-sectional and retrospective cohort. METHODS: Reviewed computerized records of the four Miami STD cl
HIV transmission and Kaposi's sarcoma among European women.: AIDS. 1995 Aug;9(8):971-3. Unique Identifier : AIDSLINE MED/96014975; Serraino D; Franceschi S; Dal Maso L; La Vecchia C; Department of Epidemiology, Aviano Cancer Centre, Italy.; OBJECTIVE: To assess the association between the presence of Kaposi s sarcoma (KS) as an AIDS-defining illness and HIV transmission categories among European women with AIDS. DESIGN: Comparison of the prevalence of KS as an AIDS-defining illness in different HIV transmission categories. METHODS: Odds ratios (OR) and 9
Microsporidiosis in patients with relatively preserved CD4 counts [letter]: AIDS. 1995 Aug;9(8):975. Unique Identifier : AIDSLINE MED/96014976; Sowerby TM; Conteas CN; Berlin OG; Donovan J
First case of osteomyelitis due to Phialophora richardsiae in a patient with HIV infection [letter]: AIDS. 1995 Aug;9(8):975-6. Unique Identifier : AIDSLINE MED/96014977; Uberti-Foppa C; Fumagalli L; Gianotti N; Viviani AM; Vaiani R; Gieho E
Plasma HIV-1 load and nosocomial transmission in Romanian children [letter]: AIDS. 1995 Aug;9(8):977. Unique Identifier : AIDSLINE MED/96014978; Apetrei C; Descamps D; Panzaru C; Duca MC; Simon F; Brun-Vezinet F
HIV-1 group O sensitivity to antiretroviral drugs [letter]: AIDS. 1995 Aug;9(8):977-8. Unique Identifier : AIDSLINE MED/96014979; Descamps D; Collin G; Loussert-Ajaka I; Saragosti S; Simon F; Brun-Vezinet F
Production of nitric oxide from peripheral blood mononuclear cells and polymorphonuclear leukocytes of patients with HIV-1 [letter]: AIDS. 1995 Aug;9(8):979-80. Unique Identifier : AIDSLINE MED/96014980; Torre D; Ferrario G; Bonetta G; Speranza F; Zeroli C
Endophthalmitis as a complication of intravitreal treatment for cytomegalovirus retinitis [letter]: AIDS. 1995 Aug;9(8):980-1. Unique Identifier : AIDSLINE MED/96014981; Collazos J; Diaz F; Mayo J; Martinez E; Fernandez A
Comment from the World Bank [letter]: AIDS. 1995 Aug;9(8):982-4. Unique Identifier : AIDSLINE MED/96014982; Feachem R; Musgrove P; Elmendorf AE
A management trial for Duchenne cardiomyopathy.: Am J Phys Med Rehabil. 1995 Sep-Oct;74(5):345-50. Unique Identifier : AIDSLINE MED/96036557; Ishikawa Y; Bach JR; Ishikawa Y; Minami R; Department of Pediatrics, Sapporo University of Medicine,; Hokkaido, Japan.; The physiatrist can now be instrumental in prolonging the survival of individuals with neuromuscular disease by using respiratory muscle aids. As a result, morbidity and mortality from cardiomyopathy are likely to increase for patients with generalized myopathies. One hundred consecutive patients with dystrophin-defic
Six billion neurons lost in AIDS. A stereological study of the neocortex.: APMIS. 1995 Jul-Aug;103(7-8):525-9. Unique Identifier : AIDSLINE MED/96033957; Oster S; Christoffersen P; Gundersen HJ; Nielsen JO; Pedersen C; Pakkenberg B; Neurological Research Laboratory, Kommunehospitalet, Copenhagen,; Denmark.; Human immunodeficiency virus type 1 (HIV1) is neurotropic. One of the morphological changes that is seen in patients with acquired immunodeficiency syndrome (AIDS) is cerebral atrophy affecting various structures including the neocortex. The cause of atrophy is not known. The total number of neocortical neurons was es
Beta 2-microglobulin expression of AIDS-related and classical Kaposi's sarcoma.: APMIS. 1995 Jul-Aug;103(7-8):553-7. Unique Identifier : AIDSLINE MED/96033961; Petersen BL; Petersen CL; Jensen A; Thomsen HK; Werdelin O; Braendstrup O; Department of Pathology, Glostrup Hospital, Denmark.; The expression of beta 2-microglobulin, the invariable light chain of HLA class I molecules, of Kaposi s sarcoma from 11 AIDS patients and from 11 patients without known immunodeficiency was studied by immunohistochemistry using a polyclonal antibody to beta 2-microglobulin. The staining intensity of spindle cells in
Infection, apoptosis, and killing of mature human eosinophils by human immunodeficiency virus-1.: Am J Respir Cell Mol Biol. 1995 Nov;13(5):610-20. Unique Identifier : AIDSLINE MED/96054928; Weller PF; Marshall WL; Lucey DR; Rand TH; Dvorak AM; Finberg RW; Department of Medicine, Harvard Thorndike Laboratories, Charles; A. Dana Research Institute, Beth Israel Hospital, Harvard Medical; School, Boston, Massachusetts 02215, USA.; Although human eosinophils express low concentrations of CD4, the capacity of mature, non-replicating eosinophils to be infected with human immunodeficiency virus-1 (HIV-1) has not been established. Using peripheral blood eosinophils isolated free of contaminating lymphocytes and mononuclear leukocytes, we evaluated e
Detection of a 67-kD glycoprotein in human tumor cell lines by a monoclonal antibody established against a recombinant human endogenous retrovirus-K envelope-gene-encoded protein.: Exp Clin Immunogenet. 1995;12(2):96-102. Unique Identifier : AIDSLINE MED/96100697; Vogetseder W; Feng J; Haibach C; Mayerl W; Dierich MP; Institut fur Hygiene, Leopold-Franzens-Universitat Innsbruck,; Osterreich.; Endogenous retroviruses in humans are discussed as putative etiologic agents in tumorigenesis. Molecular mimicry of cellular epitopes by retroviruses may be of importance for the genesis of autoimmune diseases. A group of human endogenous retroviruses, HERV-K, which is related to the mouse mammary tumour virus, has be
Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates.: AIDS Res Hum Retroviruses. 1995 May;11(5):533-9. Unique Identifier : AIDSLINE MED/96093887; Allaway GP; Davis-Bruno KL; Beaudry GA; Garcia EB; Wong EL; Ryder AM; Hasel KW; Gauduin MC; Koup RA; McDougal JS; et al; Progenics Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.; CD4-IgG2 is a novel fusion protein comprising human IgG2 in which the Fv portions of both heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This tetrameric protein is being developed as an immunoprophylactic agent to reduce the probability of infection following HIV-1 exposure, in settin
Inhibition of HIV type 1 infection of mononuclear phagocytes by anti-CD44 antibodies.: AIDS Res Hum Retroviruses. 1995 May;11(5):541-6. Unique Identifier : AIDSLINE MED/96093888; Rivadeneira ED; Sauls DL; Yu Y; Haynes BF; Weinberg JB; Department of Pediatrics, VA Medical Center, Durham, North; Carolina 27705, USA.; Cellular CD4 is the primary membrane molecule that binds HIV-1 through interaction with viral gp120. Membrane glycolipids and cell adhesion molecules have also been noted to be involved in the interaction of HIV-1 with cells and in syncytium formation in infected cells. The purpose of this study was to determine the r
HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):547-53. Unique Identifier : AIDSLINE MED/96093889; Castilletti C; Capobianchi MR; Fais S; Abbate I; Ficociello B; Ameglio F; Cordiali Fei P; Santini SM; Dianzani F; Institute of Virology, University La Sapienza, Rome.; Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have
Insulin-like growth factor 1 and insulin inhibit HIV type 1 replication in cultured cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):555-61. Unique Identifier : AIDSLINE MED/96093890; Germinario RJ; DeSantis T; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.; Insulin-like growth factor 1 and insulin, considered primarily as metabolic and growth modulatory hormones, were found to inhibit the replication of HIV-1 in cultured cord blood mononuclear cells and chronically HIV-infected U937 cells. The effect of IGF-1 was seen at physiological concentrations or lower (1.7 x 10(-1
Characterization of V3 loop-binding protein(s) of Molt-4 and U937 cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):563-70. Unique Identifier : AIDSLINE MED/96093891; Xu Y; Murakami T; Kawase S; Uchiyama T; Hattori T; Laboratory for AIDS Immunology, Kyoto University, Japan.; The V3 loop in gp120 of human immunodeficiency virus type 1 (HIV-1) is known as a principal neutralizing and cell-tropic determinant. Biotinylated synthetic V3 loop peptides derived from three different HIV-1 strains were used as ligands to identify the cell surface counterreceptor, which may participate in the infect
Single basic amino acid substitutions at position 302 or 320 in the V3 domain of HIV type 1 are not sufficient to alter the antiviral activity of dextran sulfate and heparin.: AIDS Res Hum Retroviruses. 1995 May;11(5):571-5. Unique Identifier : AIDSLINE MED/96093892; Okada T; Gurney ME; Department of Cell, Molecular, and Structural Biology,; Northwestern University Medical School, Chicago, Illinois 60611,; USA.; The third variable domain (V3 domain) of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 contains a substantial number of positively charged amino acid residues. We previously demonstrated that mutation of basic amino acid residues at position 303, 306, 309, 313, and 325 in the V3 domain of
Direct interaction of complement factor H with the C1 domain of HIV type 1 glycoprotein 120.: AIDS Res Hum Retroviruses. 1995 May;11(5):577-88. Unique Identifier : AIDSLINE MED/96093893; Pinter C; Siccardi AG; Longhi R; Clivio A; Dipartimento di Biologia e Genetica per le Scienze Mediche,; Universita di Milano, Milan, Italy.; A protein that binds specifically to Env 105-119 (HEDIISLWDQSLKPC) was found in pools of normal human plasma when this peptide was used in affinity chromatography procedures. These samples represented the negative control in experiments aimed at the purification of putative human antibodies to the Env 105-119 region f
Seroreactivity of analogous antigenic epitopes in glycoprotein 120 expressed in HIV-1 subtypes A, B, C, and D.: AIDS Res Hum Retroviruses. 1995 May;11(5):589-96. Unique Identifier : AIDSLINE MED/96093894; Pestano GA; Hosford KS; Spira AI; Riley J; Xie JM; Sewankambo N; Brown L; Ho DD; Boto WM; Department of Biology, City College of the City University of New; York, New York 10031, USA.; This article describes the impact of sequence variation on the distribution and seroreactivity of linear antigenic epitopes in gp120 encoded in new Ugandan HIV-1 clones from subtypes A, C, and D, and in North American clones from the B subtype. A region of the env gene encoding the C2 to V5 domains was PCR amplified f
Characterization of HIV type 1 from Romanian children: lack of correlation between V3 loop amino acid sequence and syncytium formation in MT-2 cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):597-603. Unique Identifier : AIDSLINE GENBANK/X77987; Holm-Hansen C; Grothues D; Rustad S; Rosok B; Pascu FR; Asjo B; Centre for International Health, University of Bergen, Norway.; The biological properties and amino acid sequences of the third variable domain (V3 loop and flanking regions) of the env region of 34 HIV-1 isolates obtained from Romanian children were analyzed. Unambiguous nucleic acid sequences were obtained from 31 isolates. The derived V3 amino acid sequences were highly homolog
Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela.: AIDS Res Hum Retroviruses. 1995 May;11(5):605-16. Unique Identifier : AIDSLINE GENBANK/U16779; Quinones-Mateu ME; Dopazo J; Este JA; Rota TR; Domingo E; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM),; Universidad Autonoma de Madrid, Cantoblanco, Spain.; Eight HIV-1 isolates from Venezuela have been characterized by nucleotide sequencing of the entire reverse transcriptase (RT)- and surface glycoprotein (gp 120)-coding regions. Average mutant frequencies were 2.5 x 10(-2) substitutions per nucleotide (s/nt) for the RT-coding reg
Intrapatient variability of the human immunodeficiency virus type 2 envelope V3 loop.: AIDS Res Hum Retroviruses. 1995 May;11(5):617-23. Unique Identifier : AIDSLINE GENBANK/U24388; Sankale JL; de la Tour RS; Renjifo B; Siby T; Mboup S; Marlink RG; Essex ME; Kanki PJ; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; Studies of HIV-2 infection have shown lower rates of sexual and perinatal transmission and a prolonged incubation period to AIDS as compared to HIV-1. To evaluate the role of genetic variation in HIV pathogenesis, we studied intrapatient variability in the V3 loop of the HIV-2 envelope gene over time in five seroposit
Nucleotide sequence and restriction fragment length polymorphism analysis of the long terminal repeat of human T cell leukemia virus type II.: AIDS Res Hum Retroviruses. 1995 May;11(5):625-36. Unique Identifier : AIDSLINE GENBANK/L37146; Eiraku N; Monken C; Kubo T; Zhu SW; Rios M; Bianco C; Hjelle B; Nagashima K; Hall WW; Department of Medical Virology, Rockefeller University, New York,; New York 10021, USA.; Molecular studies have demonstrated the existence of two major subtypes of human T cell leukemia virus type II: HTLV-IIa and HTLV-IIb. In attempts to further classify this family of viruses we have carried out nucleotide sequence and restriction fragment length polymorphism (RFLP) analysis of the long terminal repeat
Extraordinary high rate of HTLV type II seropositivity in intravenous drug abusers in south Vietnam.: AIDS Res Hum Retroviruses. 1995 May;11(5):637-45. Unique Identifier : AIDSLINE MED/96093899; Fukushima Y; Takahashi H; Hall WW; Nakasone T; Nakata S; Song P; Dinh Duc D; Hien B; Nguyen XQ; Ngoc Trinh T; et al; Laboratory of Immunology, AIDS Research Center, National; Institute of Health, Tokyo, Japan.; Serum specimens (n = 1899) were assayed for infections with HTLV-I, HTLV-II, and HIV-1 in seven classified groups of normal healthy controls, children, pregnant women, prostitutes, intravenous drug abusers, patients under going hemodialysis, and hemophiliacs in South and North Vietnam
Presence of the widespread subtype of HTLV-I in South Africa.: AIDS Res Hum Retroviruses. 1995 May;11(5):645-7. Unique Identifier : AIDSLINE MED/96093900; Yamashita M; Takehisa J; Miura T; Ido E; Becker WB; Robson BA; Becker ML; Hayami M; Laboratory of Pathogenic Virus, Institute for Virus Research,; Kyoto University, Japan.
Analysis of HTLV-I Env gene sequence from an Italian polytransfused patient: evidence for a Zairian HTLV-I in Sicily.: AIDS Res Hum Retroviruses. 1995 May;11(5):649-51. Unique Identifier : AIDSLINE MED/96093901; Boeri E; Abecasis C; Varnier OE; Franchini G; Laboratorio di Virologia, Centro S. Luigi, Ospedale San; Raffaelle, Via Stamira d'Ancona, Milano, Italy.
HIV-1 gp120 sequences from a doubly infected drug user.: AIDS Res Hum Retroviruses. 1995 May;11(5):653-5. Unique Identifier : AIDSLINE GENBANK/U20677; Sala M; Pelletier E; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.
Identification of HIV-1 subtype G from Uganda.: AIDS Res Hum Retroviruses. 1995 May;11(5):657-9. Unique Identifier : AIDSLINE GENBANK/U22010; Kaleebu P; Bobkov A; Cheingsong-Popov R; Bieniasz P; Garaev M; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; St. Mary's Hospital Medical School, London, UK.
Molecular cloning and characterization of a TAR-binding nuclear factor from T cells.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):663-9. Unique Identifier : AIDSLINE GENBANK/L22453; Reddy TR; Suhasini M; Rappaport J; Looney DJ; Kraus G; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; The TAt protein of the human immunodeficiency virus type 1 (HIV-1) activates the expression of viral mRNA through a cis-acting element in the LTR termed TAR. TAR RNA forms a stable stem-loop structure. Mutagenesis studies indicate that the stem structure, the primary sequence of the loop, and three unpaired bases in t
Resistance of HIV type 1 to proteinase inhibitor Ro 31-8959.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):671-6. Unique Identifier : AIDSLINE MED/96078227; Eberle J; Bechowsky B; Rose D; Hauser U; von der Helm K; Gurtler L; Nitschko H; Max von Pettenkofer Institute, University of Munich, Germany.; During replication of human immunodeficiency virus type 1 (HIV-1), proteolytic cleavage of Gag and Gag-Pol precursor proteins into different functional protein subunits is catalyzed by the viral proteinase, and this enzyme is the target of the antiviral proteinase inhibitor, Ro 31-8959. We investigated in vitro which
Antivirals that target the amino-terminal domain of HIV type 1 glycoprotein 41.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):677-86. Unique Identifier : AIDSLINE MED/96078228; Gordon LM; Waring AJ; Curtain CC; Kirkpatrick A; Leung C; Faull K; Mobley PW; Department of Pediatrics, Drew University-King Medical; Center/UCLA 90059, USA.; Functional and structural studies were made to assess whether a class of antiviral agents targets the N-terminal domain of the glycoprotein 41,000 (gp41) of human immunodeficiency virus type 1 (HIV-1). Previous experiments have shown that the amino-terminal peptide (FP-I; 23 amino acids, residues 519-541) of HIV-1 gp4
Multifaceted consequences of anti-gp41 monoclonal antibody 2F5 binding to HIV type 1 virions.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):687-96. Unique Identifier : AIDSLINE MED/96078229; Neurath AR; Strick N; Lin K; Jiang S; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021, USA.; A human monoclonal antibody (MAb) (2F5) neutralizing a variety of laboratory strains and clinical isolates of the human immunodeficiency virus type 1 (HIV-1) and binding to an epitope of the envelope glycoprotein gp41 encompassing the amino acid sequence ELDKWA has been described (Muster T et al., J Virol 1993;67:6642
Syncytium formation in cultured human lymphoid tissue: fusion of implanted HIV glycoprotein 120/41-expressing cells with native CD4+ cells.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):697-704. Unique Identifier : AIDSLINE MED/96078230; Margolis LB; Glushakova S; Baibakov B; Zimmerberg J; Laboratory of Theoretical and Physical Biology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.; While glycoprotein gp120/41 clearly causes HIV-infected cells to form syncytia in monolayers and in suspension, there is unfortunately scant knowledge on syncytium formation in tissues. We implanted gp120/41-expressing cells labeled with fluorescent particles inside blocks of human lymphoid tissue kept in long-term hi
Membrane-interactive phospholipids inhibit HIV type 1-induced cell fusion and surface gp160/gp120 binding to monoclonal antibody.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):705-12. Unique Identifier : AIDSLINE MED/96078231; Krugner-Higby L; Goff D; Edwards T; Iyer N; Neufeld J; Kute T; Morris-Natschke S; Ishaq K; Piantadosi C; Kucera LS; Department of Comparative Medicine, Wake Forest University; Medical Center, Winston-Salem, North Carolina 27157-1064, USA.; Membrane-interactive phospholipids (PLs), previously evaluated for activity against HIV-1 in vitro, are known to affect late steps in viral replication. Studies were done to determine the effects of PL analogs on post-translational processing of HIV-1 proteins, binding of viral surface gp160/gp120 to CD4 receptor, and
Altered constitutive and stress-regulated heat shock protein 27 expression in HIV type 1-infected cell lines.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):713-7. Unique Identifier : AIDSLINE MED/96078232; Brenner BG; Tao Y; Pearson E; Remer I; Wainberg MA; McGill AIDS Centre, Lady Davis Institute of the Sir Mortimer B.; Davis Jewish General Hospital, Montreal, Quebec, Canada.
Local synthesis of IgG antibodies to HIV within the female and male genital tracts during asymptomatic and pre-AIDS stages of HIV infection.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):719-29. Unique Identifier : AIDSLINE MED/96078233; Belec L; Tevi-Benissan C; Lu XS; Prazuck T; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.; Paired sera and cervicovaginal secretions or seminal fluids, obtained from HIV-1-infected, clinically asymptomatic women (n = 41) and men (n = 12), were investigated in order to test the hypothesis of a local synthesis of IgG to HIV in the female and male reproductive tracts. Anti-gp41 + p24 IgG was evaluated by an Ig
In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):731-40. Unique Identifier : AIDSLINE MED/96078234; Scadden DT; Levine JD; Bresnahan J; Gere J; McGrath J; Wang Z; Resta DJ; Young D; Hammer SM; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston, Massachusetts 02215, USA.; OBJECTIVE: To determine the safety, tolerance, and hematological and virological effects of the recombinant hematopoietic growth factor interleukin 3 (IL-3) in HIV-1-infected individuals with cytopenia. DESIGN AND METHODS: A phase I single-center trial was conducted with patients in cohorts of three receiving one of f
T cell blastogenic responses to Toxoplasma gondii trophozoites among HIV-infected patients.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):741-6. Unique Identifier : AIDSLINE MED/96078235; Carrega G; Canessa A; Argenta P; Cruciani M; Bassetti D; Department of Infectious Diseases, University of Genoa, Italy.; OBJECTIVE: To evaluate the cell-mediated immune response to Toxoplasma gondii (T. gondii) among HIV-infected patients. METHODS: Forty HIV-infected patients were studied. Of them, 35 had antibodies to T. gondii and 5 had not. Nine of 35 patients with detectable serum Toxoplasma antibodies were classified as group A1 (C
Defective natural killer cell cytotoxic activity in feline immunodeficiency virus-infected cats.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. Unique Identifier : AIDSLINE MED/96078236; Zaccaro L; Falcone ML; Silva S; Bigalli L; Cecchettini A; Giorgi F; Malvaldi G; Bendinelli M; Centro Retrovirus, Universita di Pisa, Italy.; Flow cytometry has been employed to study NK cell cytotoxic activity in cats infected with feline immunodeficiency virus. The results show that animals infected for 12 months or more have decreased levels of NK cell cytotoxic activity in their blood. The impairment could not be overcome by in vitro treatment of effect
Animal models recapitulate aspects of HIV/CNS disease.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):753-9. Unique Identifier : AIDSLINE MED/96078237; Vitkovic L; Stover E; Koslow SH; Division of Neuroscience and Behavioral Science, National; Institute of Mental Health, National Institutes of Health,; Rockville, Maryland 20857, USA.; Neurobehavioral and pathological data indicate that the central nervous system (CNS) becomes infected with HIV-1 soon after the virus enters the body. However, neuropathogenesis of HIV-1 infection is difficult to investigate because the brain parenchyma is not accessible to sampling during the course of AIDS. The seco
Multiple enhancer motifs in HIV type 1 strains from Ethiopia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):761-4. Unique Identifier : AIDSLINE GENBANK/U15071; Johansson B; Sherefa K; Sonnerborg A; Division of Clinical Virology, Huddinge University Hospital,; Karolinska Institutet, Sweden.
Partial nucleotide sequence analysis of the first case of human T lymphotropic virus type II from Australia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):765-7. Unique Identifier : AIDSLINE GENBANK/U25958; Bolton WV; Kenrick KG; Dwyer DE; Cunningham AL; Wylie BR; Saksena NK; Department of Virology and Biochemistry, NSW Red Cross Blood; Transfusion Service, Sydney, Australia.
National Cancer Institute 1995 annual meeting, Laboratory of Tumor Cell Biology, Bethesda, Maryland, August 27-September 2, 1995. Abstracts.: AIDS Res Hum Retroviruses. 1995 Aug;11 Suppl 1:S1-185. Unique Identifier : AIDSLINE MED/96071995
[Acalculous cholecystitis and intestinal cryptosporidiosis: frequent association in HIV patients]: Rev Esp Enferm Dig. 1995 Aug;87(8):593-6. Unique Identifier : AIDSLINE MED/96059227; Salvador Grande F; Saiz Monzon L; De la Torre P; Yuguero del Moral L; Lorenzo Gonzalez JF; Mijan de la Torre A; Five cases of acalculous cholecystitis associated with Cryptosporidium intestinal infection in HIV infected patients are reported. Clinical, Biological and Microbiological features as well as imaging studies are described. All the patients were males. Risk factors for HIV infection included previous I.V. drug abuse (3
Anaesthetic management of caesarean section in a patient with active recurrent genital herpes and AIDS-related dementia.: Br J Anaesth. 1995 Nov;75(5):639-41. Unique Identifier : AIDSLINE MED/96096028; Birnbach DJ; Bourlier RA; Choi R; Thys DM; Department of Anesthesiology, St Luke's-Roosevelt Hospital; Center, College of Physicians and Surgeons of Columbia; University, New York, New York 10019, USA.; We report the anaesthetic management of a pregnant patient with multiple manifestations of HIV infection who underwent Caesarean section. A 30-yr-old, HIV-positive, Haitian woman presented with acute psychosis at 28 weeks gestation. A diagnosis of HIV dementia complex was made and
HIV-related knowledge and risk behaviors of street youth in Belo Horizonte, Brazil. The Street Youth Study Group.: AIDS Educ Prev. 1995 Aug;7(4):287-97. Unique Identifier : AIDSLINE MED/96026583; Raffaelli M; Siqueira E; Payne-Merritt A; Campos R; Ude W; Greco M; Greco D; Ruff A; Halsey N; Universidade Federale de Minas Gerais, Belo Horizonte, Brazil.; Individual interviews were conducted with 379 youth who work and/or live on the streets of a large Brazilian city to assess HIV-related knowledge, sources of information, risk behaviors, and prevention beliefs and strategies. Respondents demonstrated high levels of factual knowledge about HIV transmission (84% correct
The perceived social context of AIDS: study of inner-city sexually transmitted disease clinic patients.: AIDS Educ Prev. 1995 Aug;7(4):298-307. Unique Identifier : AIDSLINE MED/96026584; Kalichman SC; Adair V; Somlai AM; Weir SS; Center for AIDS Intervention Research, Medical College of; Wisconsin, USA.; The present study investigated perceptions of AIDS as a social problem relative to 10 other problems in a sample of 194 inner-city sexually transmitted disease (STD) clinic patients. Within-subjects analyses showed that AIDS was viewed as a more serious problem than housing, alcoholism, and child care, while AIDS was
Reducing HIV needle risk behaviors among injection-drug users in the Midwest: an evaluation of the efficacy of standard and enhanced interventions.: AIDS Educ Prev. 1995 Aug;7(4):308-19. Unique Identifier : AIDSLINE MED/96026585; Siegal HA; Falck RS; Carlson RG; Wang J; Wright State University, School of Medicine, Substance Abuse; Intervention Programs, Dayton, Ohio 45401, USA.; This study compares the impact of a standard and an enhanced intervention on the needle-use behaviors reported by injection-drug users (IDUs) living in a low-seroprevalence area in the Midwest. Data on the drug- and needle-use practices of 381 IDUs completing a standard (n = 232) or an enhanced (n = 149) intervention
AIDS prevention with adolescents.: AIDS Educ Prev. 1995 Aug;7(4):320-36. Unique Identifier : AIDSLINE MED/96026586; Rotheram-Borus MJ; Mahler KA; Rosario M; Department of Psychiatry, University of California, Los Angeles,; USA.; Prevention of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) among adolescents is increasingly recognized as an important public health priority. Sexual risk acts associated with HIV/AIDS transmission (unprotected sexual intercourse with multiple partners of unknown serostatus) are ty
Early childhood differentials in mother-child AIDS-information interaction.: AIDS Educ Prev. 1995 Aug;7(4):337-54. Unique Identifier : AIDSLINE MED/96026587; Sly DF; Riehman K; Wu C; Eberstein I; Quadagno D; Kistner J; Center for the Study of Population, Florida State University,; Tallahassee 32306-4063, USA.; To date there have been no systematic inquiries into 1) the extent of parent-child AIDS interaction; or 2) the factors that influence whether young children and their parents talk about AIDS. In our sample, from a medium-sized Southern metropolitan area, 70 percent of mothers of children in the first, third, and fifth
HIV/AIDS knowledge among the U.S. population.: AIDS Educ Prev. 1995 Aug;7(4):355-72. Unique Identifier : AIDSLINE MED/96026588; Sweat MD; Levin M; Department of Sociology, Emory University, USA.; This analysis examines knowledge of HIV and AIDS among 71,370 persons interviewed in a national sample of the U.S. population. Factor analysis of 26 questions about HIV infection and AIDS identified four distinct dimensions of AIDS knowledge: 1) transmission mechanisms; 2) commonly known nontechnical information; 3) d
[Idiopathic CD4+ lymphocytopenia: a case report]: Ann Ital Med Int. 1995 Jul-Sep;10(3):188-92. Unique Identifier : AIDSLINE MED/96045855; Frassanito MA; Iodice G; Rizzi R; Dammacco F; Dipartimento di Scienze Biomediche ed Oncologia Umana,; Universita degli Studi di Bari.; We present the case of a 47-year-old patient who was seen for recurrent opportunistic infections. Immunophenotypic analyses disclosed severe reduction of CD4+ T cells. Repeated Elisa, Western blot and polymerase chain reaction tests for HIV were negative. The low CD4+ T lymphocyte count unaccompanied by increased CD8+
Inducible nitric oxide synthase in the central nervous system.: J Mol Neurosci. 1994-95;5(4):219-29. Unique Identifier : AIDSLINE MED/96101969; Sparrow JR; Department of Ophthalmology, Cornell University Medical College,; New York, NY 10021, USA.; There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial cells can contribute to nitric oxide-mediated neural-cell damage. Elucidation of iNOS inducing signals and mechanisms regulating its augmentation and suppression may have implicati
NF-kappa B site-mediated negative regulation of the HIV-1 promoter by CCAAT/enhancer binding proteins in brain-derived cells.: J Mol Neurosci. 1994-95;5(4):241-58. Unique Identifier : AIDSLINE MED/96101971; Mondal D; Alam J; Prakash O; Department of Molecular Oncology, Alton Ochsner Medical; Foundation, New Orleans, LA 70121, USA.; Several transcription regulatory elements that interact with cellular DNA-binding proteins have been identified in the HIV-1 long terminal repeat (LTR). We have identified two sequence motifs in the U3 region of the LTR that are similar to the consensus 9-bp DNA-binding element of the CCAAT/enhancer-binding protein (C
Tumor necrosis factor-alpha in children with human immunodeficiency virus infection [editorial]: Pediatr Hematol Oncol. 1995 Jul-Aug;12(4):v-ix. Unique Identifier : AIDSLINE MED/96068070; Levy Y; Danon YL
AIDS focus. The great dilemma.: Nurs Stand. 1995 Sep 27-Oct 3;10(1):50-3. Unique Identifier : AIDSLINE MED/96051801; Irvin S
AIDS focus. Food for thought.: Nurs Stand. 1995 Sep 27-Oct 3;10(1):54-6. Unique Identifier : AIDSLINE MED/96051802; Stevenson-Bryan E
Adherence of Malassezia isolates to human keratinocytes in vitro--a study of HIV-positive patients with seborrhoeic dermatitis.: Br J Dermatol. 1995 Oct;133(4):537-41. Unique Identifier : AIDSLINE MED/96096851; Schechtman RC; Midgley G; Bingham JS; Hay RJ; Medical Mycology Department, St John's Institute of Dermatology,; St Thomas' Hospital, London, U.K.; Adherence of Malassezia yeast cells to human keratinocytes was assessed by a novel technique using double-sided Sellotape. Although adherence using double-sided Sellotape is still merely a model for in vivo adherence, it approximates to the conditions found on the skin surface. There were no differences in adhesive pr
Detection of Epstein-Barr virus in cutaneous and lymph nodal anaplastic large cell lymphomas (Ki-1+).: Br J Dermatol. 1995 Oct;133(4):542-6. Unique Identifier : AIDSLINE MED/96096852; Peris K; Niedermeyer H; Chimenti S; Radaskiewicz T; Kerl H; Hoefler H; Department of Dermatology, Universities of L'Aquila, Italy.; Epstein-Barr virus (EBV) is a gamma DNA herpes virus which is thought to play a part in the pathogenesis of some non-Hodgkin s lymphomas in individuals with or without immunodeficiency. We investigated 16 lymph nodal and 12 cutaneous anaplastic large cell lymphomas (ALCLs) (Ki-1+), all of which were in patients withou
Protracted cutaneous disorders in association with low CD4+ lymphocyte counts.: Br J Dermatol. 1995 Oct;133(4):625-9. Unique Identifier : AIDSLINE MED/96096868; Kurwa HA; Marks R; Department of Dermatology, University of Wales College of; Medicine, Heath Park, Cardiff, U.K.; We report two patients with skin disorders usually associated with severe immunosuppression, who had low CD4+ lymphocyte counts but normal immunoglobulin levels. The patients were HIV negative, and had CD4+ lymphocyte counts just above 300/mm3, but they presented with cutaneous manifestations of profound immunodeficie
Primary cutaneous cryptococcosis in an immunocompromized pigeon keeper.: Br J Dermatol. 1995 Oct;133(4):650-2. Unique Identifier : AIDSLINE MED/96096875; Goonetilleke AK; Krause K; Slater DN; Dev D; Wood ML; Basran GS; Department of Respiratory Medicine, Rotherham General Hospitals; NHS Trust, U.K.
Association of changes in monocyte antigen presentation and cytokine production in haemophilic boys with treatment and blood-borne virus infection.: Br J Haematol. 1995 Sep;91(1):191-6. Unique Identifier : AIDSLINE MED/96070648; Pasi KJ; Evans JA; Wadhwa M; Thorpe R; Hill FG; Children's Hospital, Ladywood, Birmingham.; Aspects of monocyte function (antigen presentation and cytokine production (e.g. IL-1, IL-6) have been studied in a normal control population and three groups of haemophilic boys: group 1 HIV and HCV seronegative and treated only with a single heat-treated factor VIII (FVIII) concentrate; group 2 HIV seronegative but
Evidence for the aetiological role of blood-borne virus infections in causing reduced lectin-induced T-cell proliferation in haemophilic boys.: Br J Haematol. 1995 Sep;91(1):197-202. Unique Identifier : AIDSLINE MED/96070649; Evans JA; Pasi KJ; Hill FG; Department of Haematology, Children's Hospital, Ladywood,; Birmingham.; T-lymphocyte function, as expressed by polyclonal proliferation to lectin mitogens phytohaemagglutinin and concanavalin A, has been studied in a normal control population and three groups of haemophilic boys: group 1, HIV and HCV seronegative and treated only with a single heat-treated factor VIII (FVIII) concentrate;
Management of persistent B19 parvovirus infection in AIDS.: Br J Haematol. 1995 Sep;91(1):90-2. Unique Identifier : AIDSLINE MED/96070630; Ramratnam B; Gollerkeri A; Schiffman FJ; Rintels P; Flanigan TP; Department of Medicine, Miriam Hospital, Brown University School; of Medicine, Providence, Rhode Island, USA.; An HIV+ 26-year-old white man with a CD4 count of 0.06 x 10(9)/l was found to have red blood cell aplasia secondary to B19 parvovirus infection. Regular infusions of intravenous immunoglobulin (IVIG) were begun and resulted in marked reticulocytosis and correction of anaemia. The patient has been followed for over 4 y
Diagnosis of HIV infection from bloodstains by PCR. A further marker for identification.: Int J Legal Med. 1995;107(6):296-300. Unique Identifier : AIDSLINE MED/96022709; Giorgetti R; Rassu M; Tagliabracci A; Franchin E; Palu G; Ferrara SD; Istituto di Medicina Legale dell'Universita di Padova, Italy.; The forensic usefulness of the detection of HIV infection in bloodstains is linked to the increasing spread of HIV infection and the consequent rise in the number of forensic cases involving HIV-positive subjects. This study was designed to detect HIV infection in bloodstains of various ages obtained from HIV-positive
A simple and rapid flow cytometric method to measure lymphocyte activation in HIV+ subjects. Diminished response to pokeweed mitogen in early disease.: Anal Cell Pathol. 1995 Jun;8(4):345-55. Unique Identifier : AIDSLINE MED/96082377; Jagers E; De Brabander M; Baisier A; De Cree J; Verhaegen H; Verbiest W; Stoffels P; Clinical Research Unit St. Bartholomeus, Jan Palfijn Hospital,; Merksem, Belgium.; It was our objective to investigate the effect of asymptomatic infection with HIV on the expression of lymphocyte activation markers after stimulation with mitogens. Whole blood cultures were made of HIV+ and HIV- subjects (29 asymptomatic HIV-1-infected subjects and 33 apparently healthy normal volunteers). At variou
Th1 and Th2 help for B cells: differential capacity for induction of autonomous responsiveness to IL-2.: Int Immunol. 1995 Jun;7(6):1021-7. Unique Identifier : AIDSLINE MED/96082369; Poudrier J; Owens T; Department of Medicine, McGill University, Montreal, Quebec,; Canada.; Sustained interaction with Th1 cells has been shown to induce IL-2 responsiveness by murine B cells. This is equivalently dependent on CD40, CD54/ICAM-1 and MHC II ligation, and co-cross-linking of CD54 and MHC II in the presence of IL-5 up-regulates a functional IL-2R
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice.: Int Immunol. 1995 Jun;7(6):975-84. Unique Identifier : AIDSLINE MED/96082364; Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139, USA.; We have bred to homozygosity gene disruptions for the transporter associated with antigen processing 1 (TAP1) and beta 2-microglobulin (beta 2m), each of which plays a distinct role in providing class I MHC subunits. Surface expression of H-2Kb or Db on cells derived from TAP1/beta 2m -/- mice was undetectable by immu
A peptide from the heptad repeat of human immunodeficiency virus gp41 shows both membrane binding and coiled-coil formation.: Biochemistry. 1995 Oct 17;34(41):13390-7. Unique Identifier : AIDSLINE MED/96027453; Rabenstein M; Shin YK; Department of Chemistry, University of California, Berkeley; 94720, USA.; The envelope glycoprotein gp41 from human immunodeficiency virus type 1 (HIV-1) is involved in membrane fusion and virus entry. It contains a functionally important leucine zipper-like heptad repeat region (residues 553-590). To investigate the solution structure and membrane-binding properties of this region, cystein
A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein.: Biochemistry. 1995 Nov 21;34(46):14955-62. Unique Identifier : AIDSLINE MED/96072732; Blacklow SC; Lu M; Kim PS; Howard Hughes Medical Institute, Whitehead Institute for; Biomedical Research, Department of Biology, Massachusetts; Institute of Technology, Cambridge 02142, USA.; Previous attempts to define the oligomeric state of the HIV and SIV envelope glycoproteins have yielded conflicting results. We have produced in Escherichia coli a recombinant model for the ectodomain of the SIV envelope protein gp41 and have identified a small, trimeric subdomain by proteolytic digestion of this gp41
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.: Biochemistry. 1995 Nov 21;34(46):15111-22. Unique Identifier : AIDSLINE MED/96072749; Mazumder A; Gazit A; Levitzki A; Nicklaus M; Yung J; Kohlhagen G; Pommier Y; Laboratories of Molecular Pharmacology and Medicinal Chemistry,; National Cancer Institute, Bethesda, Maryland 20892, USA.; Efficient replication of HIV-1 requires establishment of the proviral state, i.e., the integration of a DNA copy of the viral genome, synthesized by reverse transcriptase, into a chromosome of the host cell. Integration is catalyzed by the viral integrase protein. We have previously reported that phenolic moieties in
Female prostitutes in south London: use of heroin, cocaine and alcohol, and their relationship to health risk behaviours.: AIDS Care. 1995;7(3):253-60. Unique Identifier : AIDSLINE MED/96067995; Gossop M; Powis B; Griffiths P; Strang J; Drug Transitions Project, National Addiction Centre, Maudsley; Hospital, London, UK.; The present study looks at the association between drug and alcohol use and sexual risk behaviours in a sample of 51 women who were currently working as prostitutes and also currently using opiates and/or stimulants. Most women reported regularly using condoms with clients but a substantial minority sometimes had unpr
Unconventional conceptions and HIV.: AIDS Care. 1995;7(3):261-76. Unique Identifier : AIDSLINE MED/96067996; Macaulay L; Kitzinger J; Green G; Wight D; Medical Research Council Medical Sociology Unit, Glasgow, UK.; The condom is widely recommended as the principal method for preventing HIV transmission, but such advice obviously does not apply to women who are seeking to become pregnant. In this sense, safer sex is incompatible with reproduction. Existing research into HIV transmission has examined the choices made by those wi
Risky heterosexual practices amongst women over 30: gender, power and long term relationships.: AIDS Care. 1995;7(3):277-93. Unique Identifier : AIDSLINE MED/96067997; Maxwell C; Boyle M; Psychology Department, Claybury Hospital, Woodford Bridge, Essex,; UK.; Statistics suggest that older and younger people are about equally at risk for HIV infection, yet existing research on heterosexuality and safer sexual practices has tended to focus on people under the age of 25. The present qualitative study investigates risk behaviours and the practice of safer sex in older populati
Perceived function of and barriers to condom use in Arusha and Kilimanjaro regions of Tanzania.: AIDS Care. 1995;7(3):295-305. Unique Identifier : AIDSLINE MED/96067998; Mnyika KS; Kvale G; Klepp KI; Department of Epidemiology & Biostatistics, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.; This paper presents data from a population-based survey which assessed perceived function of and barriers to condom use among the adult population aged 15-54 years in the Arusha and Kilimanjaro regions in northern Tanzania . A structured questionnaire was used in data collection.
Reliance by gay men and intravenous drug users on friends and family for AIDS-related care.: AIDS Care. 1995;7(3):307-19. Unique Identifier : AIDSLINE MED/96067999; Johnston D; Stall R; Smith K; Joint Program in Medical Anthropology, University of California,; San Francisco, USA.; A group of gay-identified men (n = 81) and intravenous drug users (n = 88) diagnosed with AIDS in San Francisco were interviewed regarding their use of friends and family to meet their care needs. Analytic of quantitative data revealed that gay men relied more than did IDUs on friends for care. Neither group relied pr
In-patient care for symptomatic, HIV-infected persons: a longitudinal study of hospitalizations, in-patient drug use, and related costs.: AIDS Care. 1995;7(3):321-36. Unique Identifier : AIDSLINE MED/96068000; Dijkgraaf MG; Luijben AH; Jager JC; Schrijvers AJ; Borleffs JC; Department of Internal Medicine, University Hospital Utrecht, The; Netherlands.; Patterns in the costs of hospital in-patient care and in-patient drug treatment of 121 symptomatic, HIV-infected patients are described for a university hospital between 1987 and 1991. Trend analyses have been performed on quarterly and yearly data using parametric and non-parametric statistical techniques. During the
Friends and lovers: needle sharing in young people in Western Australia.: AIDS Care. 1995;7(3):337-51. Unique Identifier : AIDSLINE MED/96068001; Loxley W; Ovenden C; National Centre for Research into the Prevention of Drug Abuse,; Curtin University of Technology, South Perth, Australia.; The Youth AIDS and Drugs (YAD) Study is a study of young people who inject drugs, and their risk of the transmission of HIV through needle sharing and/or unsafe sex. One hundred and five people, aged less than 21, 75% of whom were current or recent injectors, undertook in-depth interviews which were tape recorded, tra
Unmet needs for help among persons with AIDS.: AIDS Care. 1995;7(3):353-63. Unique Identifier : AIDSLINE MED/96068002; Smith MY; Rapkin BD; Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; Current trends in AIDS care in the United States , including dehospitalization and improved outpatient treatment, may place many persons with AIDS (PWAs) at increased risk for having unmet need for help with daily living demands. Using interviews with 224 PWAs, we examined the prevalenc
Women and AIDS in Zambia: a review of the psychosocial factors implicated in the transmission of HIV.: AIDS Care. 1995;7(3):365-73. Unique Identifier : AIDSLINE MED/96068003; Campbell T; Kelly M; Hillingdon Hospital, Uxbridge, Middlesex, UK.; Women are at high risk for HIV infection in Zambia . There are several interrelated factors to account for this including the economic, cultural and educational status of women. This paper explores these factors and suggests that these factors need to be thoroughly understood before
Somatic care wanted by HIV-infected intravenous drug abusers: the patients' opinions and experiences.: AIDS Care. 1995;7(3):375-9. Unique Identifier : AIDSLINE MED/96068004; Krook A; Kastrup A; Lidman K; Mann C; Stymne A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; The somatic care of HIV-infected intravenous drug abusers (IVDUs) is often combined with many problems. The addict is often an unpopular patient, but society must assume responsibility for him or her and it is important to solve care problems in an appropriate way. This study was undertaken in order to investigate wha
Guidelines for counselling adolescents with haemophilia and HIV infection and their families.: AIDS Care. 1995;7(3):381-9. Unique Identifier : AIDSLINE MED/96068005; Miller R; Social Worker/Family Therapist Haemophilia Centre, AIDS; Counselling Co-ordinator Royal Free Hampstead NHS Trust, London,; UK.; Adolescents, poised between childhood and adulthood, and their families have many challenges. It is timely to review what these are for those with haemophilia, HIV and HCV (hepatitis C) infection in the 1990s. All three conditions are life long, life threatening and incurable. The main dilemmas facing these families a
WHO Global AIDS Statistics.: AIDS Care. 1995;7(3):397-8. Unique Identifier : AIDSLINE MED/96068006
RevM10-mediated inhibition of HIV-1 replication in chronically infected T cells.: Hum Gene Ther. 1995 May;6(5):625-34. Unique Identifier : AIDSLINE MED/96078097; Escaich S; Kalfoglou C; Plavec I; Kaushal S; Mosca JD; Bohnlein E; Progenesys, Palo Alto, CA 94304, USA.; Two clinical regimens have been proposed for gene therapies of acquired immunodeficiency syndrome (AIDS): (i) Genetic modification of differentiated peripheral mononuclear cells ex vivo and (ii) gene delivery into hematopoietic stem/progenitor cells ex vivo. Various antiviral strategies targeted at different molecular
An open label, phase I/II clinical trial to evaluate the safety and biological activity of HIV-IT (V) (HIV-1IIIBenv/rev retroviral vector) in HIV-1-infected subjects.: Hum Gene Ther. 1995 Jul;6(7):941-55. Unique Identifier : AIDSLINE MED/96097136; Haubrich R; McCutchan JA; Holdredge R; Heiner L; Merritt J; Merchant B; UCSD Treatment Center 92103-6325, USA.
Genetic modification of human peripheral blood lymphocytes with a transdominant negative form of Rev: safety and toxicity.: Hum Gene Ther. 1995 Aug;6(8):997-1004. Unique Identifier : AIDSLINE MED/96022631; Fox BA; Woffendin C; Yang ZY; San H; Ranga U; Gordon D; Osterholzer J; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; A transdominant mutant form of the rev gene, M10, confers resistance to infection by the human immunodeficiency virus (HIV) in vitro and is currently under investigation as a potential intervention in acquired immunodeficiency syndrome (AIDS). In this report, we examine three issues relevant to the safety of autologou
Buprenorphine for human immunovirus-positive opiate-dependent patients [letter]: Biol Psychiatry. 1995 Jul 15;38(2):135-6. Unique Identifier : AIDSLINE MED/96067984; Montoya ID; Umbricht A; Preston KL
Factors associated with the development of Pneumocystis carinii pneumonia in 5,025 European patients with AIDS. AIDS in Europe Study Group.: Clin Infect Dis. 1995 Jul;21(1):106-13. Unique Identifier : AIDSLINE MED/96065622; Lundgren JD; Barton SE; Lazzarin A; Danner S; Goebel FD; Pehrson P; Mulcahy F; Kosmidis J; Pedersen C; Phillips AN; Hvidovre Hospital, Denmark.; This study examined the factors associated with the development of a first episode of Pneumocystis carinii pneumonia (PCP) in 5,025 patients with AIDS, including 1,976 patients with primary PCP at the time of AIDS diagnosis and 635 with primary PCP occurring subsequently. Compared with untreated patients, patients tre
Failure of culture and polymerase chain reaction to detect human immunodeficiency virus (HIV) in seronegative steady sexual partners of HIV-infected individuals.: Clin Infect Dis. 1995 Jul;21(1):122-7. Unique Identifier : AIDSLINE MED/96065624; MacGregor RR; Dubin G; Frank I; Hodinka RL; Friedman HM; Department of Medicine, University of Pennsylvania Medical; Center, Philadelphia, USA.; Because of concern that steady sexual partners of patients infected with human immunodeficiency virus (HIV) may be infected despite negative results in tests for antibody to HIV, we studied 50 sexually active couples with discordant antibody results, assessing the agreement between these serological results and those
Sinonasal non-Hodgkin's lymphoma in patients infected with human immunodeficiency virus: report of three cases and review.: Clin Infect Dis. 1995 Jul;21(1):137-49. Unique Identifier : AIDSLINE MED/96065627; Pomilla PV; Morris AB; Jaworek A; Department of Medicine, Baystate Medical Center, Springfield,; Massachusetts 01199, USA.; Non-Hodgkin s lymphoma (NHL) is a frequent complication of human immunodeficiency virus (HIV) infection, but involvement of the sinonasal region has only rarely been reported. We report three cases of AIDS-associated sinonasal NHL that occurred at our institution and review eight cases that were reported in the litera
Pulmonary infection due to Leuconostoc species in a patient with AIDS [letter]: Clin Infect Dis. 1995 Jul;21(1):225-6. Unique Identifier : AIDSLINE MED/96065645; Ferrer S; de Miguel G; Domingo P; Pericas R; Prats G
Esophageal leishmaniasis in a patient infected with the human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1995 Jul;21(1):229-30. Unique Identifier : AIDSLINE MED/96065648; Gutierrez-Macias A; Alonso-Alonso JJ; Aguirre-Errasti C
Diarrhea associated with Vibrio fluvialis infection in a patient with AIDS [letter]: Clin Infect Dis. 1995 Jul;21(1):237-8. Unique Identifier : AIDSLINE MED/96065655; Hodge TW Jr; Levy CS; Smith MA
Fatal toxic epidermal necrolysis in patients with AIDS [letter; comment]: Clin Infect Dis. 1995 Jul;21(1):240. Unique Identifier : AIDSLINE MED/96065657; Caumes E; Gentilini M
Clinical and host differences between infections with the two varieties of Cryptococcus neoformans.: Clin Infect Dis. 1995 Jul;21(1):28-34; discussion 35-6. Unique Identifier : AIDSLINE MED/96065608; Speed B; Dunt D; Fairfield Hospital for Infectious Diseases, Victoria, Australia.; A population-based register of cases of cryptococcosis in patients treated in Victoria, Australia , over a 10-year period was established for studying the epidemiologic and clinical features of infection with Cryptococcus neoformans and its two varieties, gattii and neoformans. O
Multiorgan microsporidiosis: report of five cases and review.: Clin Infect Dis. 1995 Jul;21(1):37-44. Unique Identifier : AIDSLINE MED/96065609; Gunnarsson G; Hurlbut D; DeGirolami PC; Federman M; Wanke C; Department of Medicine, New England Deaconess Hospital, Harvard; Medical School, Boston, Massachusetts, USA.; We describe five cases and review 34 reported cases of multiorgan microsporidiosis . Most of the patients with multiorgan involvement have been adults with AIDS. Organs most commonly infected include the small intestine, urinary tract, biliary tree, and eye; involvement
Disseminated microsporidiosis due to Septata intestinalis in nine patients infected with the human immunodeficiency virus: response to therapy with albendazole.: Clin Infect Dis. 1995 Jul;21(1):70-6. Unique Identifier : AIDSLINE MED/96065615; Dore GJ; Marriott DJ; Hing MC; Harkness JL; Field AS; Department of Microbiology, St. Vincent's Hospital, Sydney,; Australia.; Disseminated microsporidiosis due to the newly described species Septata intestinalis in nine patients infected with human immunodeficiency virus is described. All patients were male homosexuals; the mean age was 41 years (range, 35-58 years). They were all severely im
Clinical manifestations and implications of coinfection with Mycobacterium kansasii and human immunodeficiency virus type 1.: Clin Infect Dis. 1995 Jul;21(1):77-85. Unique Identifier : AIDSLINE MED/96065616; Witzig RS; Fazal BA; Mera RM; Mushatt DM; Dejace PM; Greer DL; Hyslop NE Jr; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana 70112, USA.; We conducted a retrospective study to further elucidate the clinical presentations and prognosis of disease due to Mycobacterium kansasii in patients infected with human immunodeficiency virus (HIV). Forty-nine HIV-infected patients first had M. kansasii isolated at a mean CD4 cell count of 62/mm3 and at a mean interv
3D-QSAR of human immunodeficiency virus (I) protease inhibitors. III. Interpretation of CoMFA results.: Drug Des Discov. 1994 Jul;12(1):29-51. Unique Identifier : AIDSLINE MED/96062924; Opera TI; Waller CL; Marshall GR; Center for Molecular Design, Washington University School of; Medicine, St. Louis, MO 63130, USA.; Comparative Molecular Field Analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm (Cramer, R.D.; et al. (1988), J. Am. Chem. Soc., 110, 5959-5967), correlates variations in the (experimental) biological activity with 3D variance in the steric and electrostatic field of m
[Tetany caused by foscarnet in a female patient with acquired immunodeficiency syndrome (letter)]: An Med Interna. 1995 Jul;12(7):358-9. Unique Identifier : AIDSLINE MED/96059757; Vela Moreno J; Pascual Catalan A; Ramos Paesa C; Arazo Garces P; Aguirre Errasti JM
Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2.: Autoimmunity. 1995;20(4):247-58. Unique Identifier : AIDSLINE MED/96048134; Pearce RB; Formby B; Healy K; Peterson CM; Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.; T cells are involved in the induction and suppression of autoimmune diabetes in nonobese diabetic (NOD) mice. Because the incidence of diabetes is 13-fold greater in NOD/Smrf females, we searched for T cell phenotypes that showed sexual dimorphism and associated with diabetes in backcross segregants. The percentage of
Whole body hyperthermia associated with beta-carotene supplementation in patients with AIDS.: Biomed Pharmacother. 1995;49(5):263-5. Unique Identifier : AIDSLINE MED/96026495; Pontiggia P; Bianchi Santamaria A; Alonso K; Santamaria L; C Golgi Institute of General Pathology, Centro Tumori, University; of Pavia, Italy.; The objective of this work was to check possible additive beneficial effects of whole body hyperthermia (WBH) associated with beta-carotene (BC) supplementation in patients with AIDS. In a pilot study, 10 HIV positive patients, (8 with AIDS and 2 with AIDS related complex, ARC), after
Isolated renal mucormycosis: case report and review.: J Am Soc Nephrol. 1995 Jun;5(12):2014-9. Unique Identifier : AIDSLINE MED/96073207; Levy E; Bia MJ; Section of Nephrology, Yale University School of Medicine, New; Haven, CT, USA.; The 15th reported case of isolated renal mucormycosis (infection of the kidney with fungus of the order Mucorales, in the absence of infection elsewhere in the body) is presented. The patient was a 36-year-old human immunodeficiency virus-infected man, actively using iv drugs, who suffered 6 wk of flank pain and fever
[Detection of STLV-1 integration in DNA extracted from formalin-fixed and paraffin-embedded material from M. arctoides by polymerase chain reaction]: Biull Eksp Biol Med. 1995 Aug;120(8):214. Unique Identifier : AIDSLINE MED/96034094; Chikobava MG; Iakovlevai KA; Shattsel' G; Lapin BA
Factors associated with extrapulmonary tuberculosis as an AIDS-defining disease in Europe. The Coordinators of AIDS surveillance in Austria, Belgium, France, Germany, Italy, Portugal, Switzerland, United Kingdom and the city of Amsterdam.: Tuber Lung Dis. 1995 Aug;76(4):281-5. Unique Identifier : AIDSLINE MED/96048189; Schwoebel V; Delmas MC; Ancelle-Park RA; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.; SETTING: Western Europe: 8 countries and the city of Amsterdam. OBJECTIVE: To identify factors associated with extrapulmonary tuberculosis (EPTB) at AIDS diagnosis among adult AIDS patients. DESIGN: The proportion of AIDS case diagnosed between January 1988 and June 1992 with EPTB was analysed by age, gender, year of
Impact of the change from an injectable to a fully oral regimen on patient adherence to ambulatory tuberculosis treatment in Dar es Salaam, Tanzania.: Tuber Lung Dis. 1995 Aug;76(4):286-9. Unique Identifier : AIDSLINE MED/96048190; Chum HJ; Ilmolelian G; Rieder HL; Msangi J; Mwinyi N; Zwahlen M; Enarson DA; Ipuge YA; Tanzania National Tuberculosis/Leprosy Programme, Ministry of; Health, Dar es Salaam, Tanzania.; OBJECTIVE: To measure the impact on patient adherence to directly observed ambulatory tuberculosis treatment substituting an all-oral treatment regimen for a regimen containing streptomycin. METHODS: The expected and observed attendance of patients during the intensive phase of anti-tuberculosis treatment was measured
Identification of Mycobacterium intracellulare by a polymerase chain reaction using species-specific primers.: Tuber Lung Dis. 1995 Aug;76(4):330-5. Unique Identifier : AIDSLINE MED/96048197; Yamazaki T; Nakamura RM; Department of Bacteriology, National Institute of Health, Tokyo,; Japan.; SETTING: The polymerase chain reaction (PCR) is a rapid and specific method used to amplify a certain DNA fragment. It is applicable to rapid diagnosis of mycobacterial infections. By use of species-specific primers, it is possible to identify mycobacteria by PCR. In this study, a newly constructed primer was tested f
The epidemiology of Mycobacterium bovis infections in animals and man: a review.: Tuber Lung Dis. 1995 Aug;76 Suppl 1:1-46. Unique Identifier : AIDSLINE MED/96085694; O'Reilly LM; Daborn CJ; Veterinary Research Laboratory, Abbotstown, Castleknock, Ireland.; Tuberculosis is primarily a respiratory disease and transmission of infection within and between species is mainly by the airborne route. Mycobacterium bovis, the cause of bovine-type tuberculosis, has an exceptionally wide host range. Susceptible species include cattle, humans, non-human primates, goats, cats dogs, p
Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection.: Blood. 1995 Nov 15;86(10):3619-39. Unique Identifier : AIDSLINE MED/96068725; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255, USA.
Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells.: Blood. 1995 Nov 15;86(10):3705-14. Unique Identifier : AIDSLINE MED/96068735; Yanagida M; Fukamachi H; Ohgami K; Kuwaki T; Ishii H; Uzumaki H; Amano K; Tokiwa T; Mitsui H; Saito H; et al; Pharmaceutical Development Laboratory, Kirin Brewery Co, Ltd,; Gunma, Japan.; Although stem cell factor (SCF) has been identified as a critical cytokine for the development of human mast cells from their progenitors, the effects of other cytokines on human mast cells are less well understood. We examined the effects of several cytokines on the survival of human mast cells of 100% purity generat
The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.: Blood. 1995 Nov 15;86(10):3823-34. Unique Identifier : AIDSLINE MED/96068748; Zauli G; Gibellini D; Caputo A; Bassini A; Negrini M; Monne M; Mazzoni M; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; The regulatory Tat protein of human immunodeficiency virus type-1 (HIV-1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T
Immune responses to major histocompatibility complex homozygous lymphoid cells in murine F1 hybrid recipients: implications for transfusion-associated graft-versus-host disease.: Blood. 1995 Oct 15;86(8):3090-6. Unique Identifier : AIDSLINE MED/96017243; Fast LD; Valeri CR; Crowley JP; Department of Medicine, Rhode Island Hospital, Providence 02903,; USA.; Graft-versus-host disease (GVHD) is currently encountered after bone marrow transplantation and transfusion. GVHD associated with transfusion (TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient receiv
Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax.: Blood. 1995 Oct 15;86(8):3109-17. Unique Identifier : AIDSLINE MED/96017245; Tatewaki M; Yamaguchi K; Matsuoka M; Ishii T; Miyasaka M; Mori S; Takatsuki K; Watanabe T; Department of Pathology, University of Tokyo, Japan.; L-selectin is an adhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium. Upon cellular activation, expression of the L-selectin gene is downregulated at both the protein and mRNA levels. To understand the mechanism of leukemic cell infiltration into organs
Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity.: Blood. 1995 Nov 1;86(9):3287-94. Unique Identifier : AIDSLINE MED/96027492; Bernstein ZP; Porter MM; Gould M; Lipman B; Bluman EM; Stewart CC; Hewitt RG; Fyfe G; Poiesz B; Caligiuri MA; Department of Hematologic Oncology, Roswell Park Cancer; Institute, Buffalo, NY 14263, USA.; Ten adult patients with human immunodeficiency virus (HIV)-associated malignancies (five with lymphoma and five with Kaposi s Sarcoma) were treated with a daily subcutaneous injection of interleukin-2 ( IL-2 ) for 90 consecutive days in a phase I dose-escalation study. S
Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.: Blood. 1995 Nov 1;86(9):3479-86. Unique Identifier : AIDSLINE MED/96027516; Webb LM; Feldmann M; Kennedy Institute of Rheumatology, Sunley Division, Hammersmith,; London, UK.; CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in
Hemoconcentration prior to serology testing in hemodiluted cadaver bone and tissue donors.: Clin Transplant. 1995 Aug;9(4):297-300. Unique Identifier : AIDSLINE MED/96039205; LeFor WM; Shires DL Jr; McGonigle AF; Shires DL 3rd; Transplantation Immunology Laboratory, LifeLink Foundation, Inc.,; Tampa, Florida, USA.; Concern about false negative serology tests for infectious diseases in hemodiluted cadaver donors resulted in issuance of new regulations and guidelines from the FDA and CDC. Bone or tissue from donors receiving > or = 4 units of blood, blood products, colloids or crystalloids within
Short-term male reproductive toxicity study with sulfasalazine in the rat.: Reprod Toxicol. 1995 May-Jun;9(3):315-26. Unique Identifier : AIDSLINE MED/96089907; Hoyt JA; Fisher LF; Swisher DK; Toxicology Research Laboratories, Eli Lilly and Company,; Greenfield, IN 46140, USA.; Sulfasalazine (2-hydroxy-5-[[4-[(2-pyridinylamino) sulfonyl] phenyl]azo]benzoic acid; SASP) was administered to rats in a short-term male reproductive toxicity study to further examine the utility of this grouping of techniques and to generate reference data with a substance that is known to cause reversible infertili
[Preliminary analysis of relationship between immunological changes and syndrome differentiation-typing in traditional Chinese medicine and prognosis with chronic idiopathic thrombocytopenic purpura]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):401-4. Unique Identifier : AIDSLINE MED/96041553; Yang YF; Zhou AX; Ma R; Dept. of Hematology, Xiyuan Hospital, China Academy of TCM,; Beijing.; In order to study the relationship between the basement immunological changes, TCM Syndrome Differentiation and prognosis, alkaline phosphates antialkaline phosphatase (APAAP) and ELISA assay were used to determine the T lymphocyte subsets, the platelet associated antibody (PAIgG, PAIgA, PAIgM) and plasma antiplatelet
[Relationship between syndrome types of TCM in lung neoplasm patients and peripheral T lymphocyte subsets, carcino-embryonic antigen]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):405-7. Unique Identifier : AIDSLINE MED/96041554; Fang CL; Zong WJ; Fan GR; Subei People Hospital, Yangzhou Medical College, Jiangsu.; Fifty-six cases with lung carcinoma were detected for peripheral blood T lymphocyte by direct staphylococcal protein A (SPA) bacterial rose ring for carcino-embryonic antigen (CEA) by radioimmunoassay, and the relationship between T lymphocyte. CEA and Syndrome of TCM was explored. The results were as follows:the valu
[A study on effect of qingwen granule in regulating immunological function in infantile respiratory viral infection]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):408-10. Unique Identifier : AIDSLINE MED/96041555; Zhang GC; Li ZH; Shen Q; Dept. of Pediatrics, Xijing Hospital, Fouth Military Medical; University, Xi'an.; To evaluate the effect of Qing-wen Granule (QWG) on immunological function, T lymphocyte subsets and interferon gamma(INF-gamma) expression cells in peripheral blood mononuclear cells, lymphocyte transformation rate and the level of salivary secretory IgA (sIgA) were determined by alkaline phosphatase antialkaline pho
Health education and safer sex.: Br J Nurs. 1995 Sep 28-Oct 11;4(17):999-1000, 1017-9. Unique Identifier : AIDSLINE MED/96051734; Winship G; Peachey A; Recent studies (e.g. Klee et al, 1991) of human immunodeficiency virus prevalence among drug users indicate that the greatest increase in transmission rates has been a result of sexual contact. This article examines safer sex health education and the development of a programme of education that aims to confront negati
Abnormalities of visual spatial attention in HIV infection and the HIV-associated dementia complex.: J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):325-33. Unique Identifier : AIDSLINE MED/96076004; Maruff P; Malone V; McArthur-Jackson C; Mulhall B; Benson E; Currie J; Neurophysiology and Neurovisual Research Unit, Mental Health; Research Institute of Victoria, Parkville, Australia.; Covert orienting of visuospatial attention (COVAT) was examined in 88 homosexual or bisexual men: 12 with mild HIV-associated dementia complex (ADC), 30 neurologically intact with AIDS (NI-AIDS), 23 asymptomatic HIV+ (HIV+ASX), and 23 HIV-negative control subjects. In mild ADC, COV
Global aspects of vaccination.: Int Arch Allergy Immunol. 1995 Dec;108(4):304-8. Unique Identifier : AIDSLINE MED/96071806; Ada G; Division of Cell Biology, John Curtin School of Medical Research,; Australian National University, Canberra, Australia.; The prospects for many children born in developing countries to reach adulthood has been transformed over the last 30 years by the activities of the Expanded Programme of Immunization (EPI) established by the World Health Organization (WHO) in 1974. By 1990, about 80% of children had b
Progress in AIDS vaccine development.: Int Arch Allergy Immunol. 1995 Dec;108(4):313-7. Unique Identifier : AIDSLINE MED/96071808; Johnston MI; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892-7620,; USA.; Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma
Features of oral immunization.: Int Arch Allergy Immunol. 1995 Dec;108(4):334-9. Unique Identifier : AIDSLINE MED/96071812; Ruedl C; Wolf H; Institute for General and Experimental Pathology, Medical School,; University of Innsbruck, Austria.; In this review, we focus on some key areas concerning the unique properties of the mucosal immune system. They are: (1) the fact that the common mucosal immune system consists of different compartments; (2) the advantages of oral vaccination, which can be exploited to antigen-specific sIgA-mediated local immune respon
Conference on AIDS criticises inaction [news]: BMJ. 1995 Sep 23;311(7008):771. Unique Identifier : AIDSLINE MED/96061742; Willott S
Acquired immunodeficiency without HIV infection: epidemiology and clinical outcome in Italy. The Italian Study Group on non-HIV AIDS.: BMJ. 1995 Sep 23;311(7008):785-6. Unique Identifier : AIDSLINE MED/96061748; Rezza G; Pezzotti P; Aiuti F; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome.
Study shows two drugs are best for HIV infection [news]: BMJ. 1995 Sep 30;311(7009):827. Unique Identifier : AIDSLINE MED/96066558; Dillner L
Needle exchanges reduce HIV infection in US [news]: BMJ. 1995 Sep 30;311(7009):832. Unique Identifier : AIDSLINE MED/96066561; Roberts J
Decreasing HIV-1 seroprevalence in young adults in a rural Ugandan cohort.: BMJ. 1995 Sep 30;311(7009):833-6. Unique Identifier : AIDSLINE MED/96066563; Mulder D; Nunn A; Kamali A; Kengeya-Kayondo J; Medical Research Council Programme on AIDS in Uganda, Entebbe.; OBJECTIVE--To assess the trend in HIV-1 seroprevalence in an adult population in Uganda . DESIGN--An observational cohort study with four year follow up. SETTING--A cluster of 15 villages in rural Uganda. SUBJECTS--All residents of the 15 villages--about 10,000 people. MAIN OUTCOME
Tropical medicine for the 21st century.: BMJ. 1995 Sep 30;311(7009):860-2. Unique Identifier : AIDSLINE MED/96066572; De Cock KM; Lucas SB; Mabey D; Parry E; London School of Hygiene and Tropical Medicine.; The specialty of tropical medicine originated from the needs of the colonial era and is removed from many of the health care requirements of tropical countries today. Tropical medicine concentrates on parasitic diseases of warm climates, although other infections and diseases related to poverty rather than climate dom
Voluntary, named testing for HIV in a community based antenatal clinic: a pilot study.: BMJ. 1995 Oct 7;311(7010):928-31. Unique Identifier : AIDSLINE MED/96011317; Chrystie IL; Wolfe CD; Kennedy J; Zander L; Tilzey A; Banatvala JE; Department of Virology, United Medical and Dental Schools of; Guy's Hospital, London.; Despite the increasing advantages of identifying HIV infection in pregnant women, only some 12% of HIV positive women attending antenatal clinics in London have been identified by named testing. As virtually all antenatal care will be community based within the next two to three years, we assessed the problems of intr
Cuba: plenty of care, few condoms, no corruption.: BMJ. 1995 Oct 7;311(7010):935-7. Unique Identifier : AIDSLINE MED/96011319; Veeken H; Medecins Sans Frontieres, Amsterdam, Netherlands.; The health system in Cuba guarantees accessibility to the entire population, is free of charge, and covers the spectrum from vaccinations to sophisticated interventions. The results are impressive: Cuba s health figures are on a par with developed countries that have 20 times the bud
Australian doctors in confidentiality controversy [news]: BMJ. 1995 Oct 14;311(7011):971-2. Unique Identifier : AIDSLINE MED/96022004; Zinn C
Japan proposes settlement for tainted blood [news]: BMJ. 1995 Oct 21;311(7012):1044-5. Unique Identifier : AIDSLINE MED/96041830; Guest R
Australia launches third AIDS strategy [news]: BMJ. 1995 Oct 21;311(7012):1045-6. Unique Identifier : AIDSLINE MED/96041832; Zinn C
Prison rites: starting to inject inside.: BMJ. 1995 Oct 28;311(7013):1135-6. Unique Identifier : AIDSLINE MED/96048854; Gore SM; Bird AG; Ross AJ; MRC Biostatistics Unit, Cambridge.
The preparedness to share injecting equipment: an analysis using vignettes.: Addiction. 1995 Sep;90(9):1253-60. Unique Identifier : AIDSLINE MED/96019279; McKeganey N; Abel M; Taylor A; Frischer M; Goldberg D; Green S; Centre for Drug Misuse Research, University of Glasgow, UK.; This paper reports on the use of vignettes to study drug injectors preparedness to share injecting equipment. Separate vignettes referring to borrowing and passing on injecting equipment have been submitted to 505 injecting drug users in Glasgow. Injectors were asked to identify their own likely response in each of t
Special issue on AIDS.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):345-452. Unique Identifier : AIDSLINE MED/96059393
Pending problem of silent human immunodeficiency virus infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):345-50. Unique Identifier : AIDSLINE MED/96059392; Bentwich Z; Bar-Yehuda S; Nagai K; Wainberg MA; Kalinkovich A; Jehuda-Cohen T; Ruth Ben Ari Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University Medical School, Rehovot, Israel.; The problem of silent HIV infection is reviewed. Overall, the number of proven silent infection in several at-risk populations, including HIV exposed health-care workers, homosexuals, IV drug addicts and children born to HIV-infected mothers, has been very low. Contrary to these observations, we describe a very high p
Kinoids: the basis for anticytokine immunization and their use in HIV infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):351-6. Unique Identifier : AIDSLINE MED/96059394; Bizzini B; Achour A; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; HIV infection is characterized, at least in part, by the dysregulation of the cytokine network. Both IFN gamma and IFN alpha are occasionally overproduced. These cytokines could participate in the HIV-induced immunosuppression. To enable a HIV-infected organism to promote an immune reaction against the virus, the immu
Kaposi's sarcoma in patients infected with human virus (HIV): an overview.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):357-64. Unique Identifier : AIDSLINE MED/96059395; Hermans P; Clumeck N; Division of Infectious Diseases, St. Pierre University Hospital,; Brussels, Belgium.; The emergence of Kaposi s sarcoma (KS) among patients with HIV infection has raised a number of unsolved questions. The particular epidemiology and the etiology of KS remain unclear while both inflammatory cytokines and HIV-derived proteins appear to be involved in its pathogenesis as shown with the aid of in vitro KS
Internal transcriptional regulatory elements in HIV-1 and other retroviruses.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):365-9. Unique Identifier : AIDSLINE MED/96059396; Verdin E; Van Lint C; Picower Institute for Medical Research, Laboratory of Molecular; Virology, Manhasset, NY 11030, USA.; The transcriptional regulation of retroviruses plays an important role in their pathogenesis. Cis-acting elements have been identified in the long terminal repeat (LTR) at the 5 extremity of the integrated provirus. These elements determine the rate and the site of transcription initiation and consist of arrays of bi
Factors associated with progression to AIDS and mortality in a cohort of HIV-infected patients with hemophilia followed up since seroconversion.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):371-80. Unique Identifier : AIDSLINE MED/96059397; Santagostino E; Gringeri A; Cultraro D; Tradati F; Siracusano L; Marinoni A; Mannucci PM; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of; Internal Medicine, IRCCS Maggiore Hospital, University of Milan,; Italy.; Progression to AIDS and death were evaluated in 112 patients, 84 with hemophilia A and 28 with hemophilia B. Seroconversion period and age at seroconversion were similar in both groups. 36/112 patients died: 21/84 with hemophilia A (25%) and 15/28 (54%) with hemophilia B. Mean survival time was 11.7 years. The 10-year
Anti-alpha interferon immunization: safety and immunogenicity in asymptomatic HIV positive patients at high risk of disease progression.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):381-7. Unique Identifier : AIDSLINE MED/96059398; Gringeri A; Santagostino E; Mannucci PM; Siracusano L; Marinoni A; Criscuolo M; Carcagno M; Fall LS; M'Bika JP; Bizzini B; et al; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of; Internal Medicine, IRCCS Maggiore Hospital, Milan, Italy.; A randomized, placebo-controlled trial was designed to evaluate safety and immunogenicity of an anti-cytokine vaccine in high risk HIV-positive patients. This strategy was aimed to modulate the impaired cytokine regulation in AIDS. Twelve asymptomatic patients on antiretroviral therapy for at least 1 year and with CD4
Production in rabbits of high levels of anti-HIV-1 gp160 antibodies.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):389-93. Unique Identifier : AIDSLINE MED/96059399; Relyveld E; Bizzini B; Institut Pasteur, Unite des Vaccins Bacteriens,; Marnes-La-Coquette, France.; The production of anti-HIV-1 gp160 antibodies was obtained in rabbits given gp160 either in saline or adsorbed onto calcium phosphate. Immunization with gp160 in saline induced the formation of antibodies directed to the p18 protein, whereas the gp160 adsorbed onto calcium phosphate elicited antibodies recognizing the
HIV-1 soluble antigens induced CD8+ cytotoxic T-cell responses in an immunized individual.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):395-400. Unique Identifier : AIDSLINE MED/96059400; Achour A; Moukrim Z; Picard O; Bizzini B; Burny A; Zagury D; Universite Pierre et Marie Curie, Paris, France.; In an attempt to determine whether immunization of healthy HIV-1 seronegative individuals with a soluble gp160 candidate vaccine could induce an anti-HIV specific immune response, volunteers were immunized by two injections of a water-in-oil emulsion containing a mixture of gp160 antigen together with selected peptide
HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):401-7. Unique Identifier : AIDSLINE MED/96059401; Sarin PS; Mora CA; Naylor PH; Markham R; Schwartz D; Kahn J; Heseltine P; Gazzard B; Youle M; Rios A; et al; Department of Biochemistry and Molecular Biology, George; Washington University Medical Center, Washington, D.C. 20037,; USA.; An HIV-1 p17 subunit vaccine, HGP-30, was evaluated in 38 HIV-1 seronegative individuals in phase I clinical trials in U.K. and U.S.A. The vaccine preparation induced cytotoxic T-cell (CTL) (11/25) and lymphocyte proliferation responses to KLH (19/20) and HGP-30/p17 (24/29) as well as antibody responses to HGP-30 (29/
Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):409-16. Unique Identifier : AIDSLINE MED/96059402; Fall LS; Chams V; Le Coq H; Fouchard M; M'Bika JP; Gringeri A; Santagostino E; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected pa
Impairment of circulating lactoferrin in HIV-1 infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):417-21. Unique Identifier : AIDSLINE MED/96059403; Defer MC; Dugas B; Picard O; Damais C; U313 INSERM, Centre de Recherche des Cordeliers, Paris, France.; Levels of plasma lactoferrin are decreased in HIV-1-infected patients in relation to the progression of the disease. Plasma lactoferrin concentrations were determined using a specific and sensitive enzyme immunoassay. 97 plasma were studied (22 asymptomatic, 45 symptomatic patients compared to 30 healthy controls) and
Which nutrient supplements for optimal HIV-1 production by cultured human lymphocytes?: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):423-30. Unique Identifier : AIDSLINE MED/96059404; Landureau JC; Achour A; Fouchard M; M'Bika JP; Maziere JC; Zagury D; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; Under standard conditions, all established cell-lines of HIV-1-infected lymphocytes are cultured in a medium containing a high percentage of serum. We have found that whilst partial or total serum depletion impedes their cell growth, it dramatically increases their virus production. Serial subcultures in serum-deplete
Contribution of alpha interferon (alpha IFN) to HIV-induced immunosuppression.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):431-7. Unique Identifier : AIDSLINE MED/96059405; Lachgar A; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; In the present investigation we have shown that PBLs taken from HIV-positive patients suppressed T-cell proliferation when cultured for at least 12 days. When infected In vitro with HIV-1, these cells become suppressive after 6 days. PBLs collected from seronegative individuals turned out to be non-suppressive even af
Cytotoxic T lymphocytes specific for the synthetic VEINCTR peptide, a sequence found within the Fas molecule and env gp120 in the blood of HIV-1 seropositive individuals.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):439-44. Unique Identifier : AIDSLINE MED/96059406; Moukrim Z; Achour A; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; We have previously identified a VEINCTR peptide common to both the Fasmolecule and HIV-1 gp120. Here we report the characterization in PBMCs from HIV-1-infected individuals of a CD8+ class I restricted CTL activity directed towards this peptide. The peptide is highly conserved in various HIV-1 strains, being located a
HIV-1 gp120/160 expressing cells upregulate HIV-1 LTR directed gene expression in a cell line transfected with HIV-1 LTR-reporter gene constructs.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):445-52. Unique Identifier : AIDSLINE MED/96059407; Merzouki A; Patel P; Cassol S; Ennaji M; Tailor P; Turcotte FR; O'Shaughnessy M; Arella M; Virology Research Center Institut Armand-Frappier, Laval, Quebec,; Canada.; The results described in this paper demonstrate that HIV-1 gp120 can upregulate gene expression directed by the HIV-1 LTR. Briefly, exposing responder CD4+CEM-T4 ID5 cells to stimulator CEMgp120/160 expressing cells (stably transfected with HIV-1 LTR-CAT and HIV-1 gp160, respectively) resulted in the increased synthes
Detection of HCV RNA by the asymmetric gap ligase chain reaction.: PCR Methods Appl. 1994 Oct;4(2):80-4. Unique Identifier : AIDSLINE GENBANK/M58335; Marshall RL; Laffler TG; Cerney MB; Sustachek JC; Kratochvil JD; Morgan RL; Abbott Laboratories, Molecular Diagnostics, Abott Park, Illinois; 60064, USA.; The ligase chain reaction (LCR) and the gap ligase chain reaction (gLCR) are exponential amplification techniques for the detection of DNA sequences in a sample. Both techniques depend on the enzyme, DNA ligase, to join adjacent probes annealed to a DNA molecule. However, DNA ligase joins DNA inefficiency on an RNA ta
Single-strand conformational polymorphism.: PCR Methods Appl. 1994 Dec;4(3):S137-40. Unique Identifier : AIDSLINE MED/96000013; Fujita K; Silver J; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA.
Quality assurance and use of PCR in clinical trials.: PCR Methods Appl. 1994 Dec;4(3):S141-9. Unique Identifier : AIDSLINE MED/96000014; Reichelderfer PS; Jackson JB; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; Qualitative and quantitative HIV-1 DNA and RNA PCR assays are proving to be useful in the diagnosis of HIV-1 infection in infants and in assessing the in vivo antiviral activity of new therapies and regimens in clinical trials. The use of these standardized commercial assays in conjunction with an external quality ass
Alteration of hairpin ribozyme specificity utilizing PCR.: PCR Methods Appl. 1994 Dec;4(3):139-44. Unique Identifier : AIDSLINE MED/96000001; DeGrandis P; Hampel A; Galasinski S; Borneman J; Siwkowski A; Altschuler M; Department of Biological Science, Northern Illinois University,; DeKalb 60115, USA.; We have developed a method by which a researcher can quickly alter the specificity of a trans hairpin ribozyme. Utilizing this PCR method, two oligonucleotides, and any target vector, new ribozyme template sequences can be generated without the synthesis of longer oligonucleotides. We have produced templates with alte
Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay.: PCR Methods Appl. 1995 Apr;4(5):S202-16. Unique Identifier : AIDSLINE GENBANK/L22085; Delwart EL; Herring B; Rodrigo AG; Mullins JI; Department of Microbiology and Immunology, Stanford University; School of Medicine, California 94305-5402, USA.
Single-tube nested PCR with room-temperature-stable reagents.: PCR Methods Appl. 1995 Jun;4(6):376-9. Unique Identifier : AIDSLINE MED/96000081; Wolff C; Hornschemeyer D; Wolff D; Kleesiek K; Institut fur Laboratoriums- und Transfusionsmedizin, Herz- und; Diabeteszentrum Nordrhein-Westfalen, Universitatsklinik der; Ruhr-Universitat Bochum, Bad Oeynhausen, Germany.
Predictors of Taiwanese nurses' intention to care for patients who are HIV positive.: Clin Nurs Res. 1995 Nov;4(4):442-64. Unique Identifier : AIDSLINE MED/96051763; Tsai YF; Keller ML; The purpose of this research was to explore the knowledge of, attitudes toward, and intention to care for HIV-positive patients among 223 Taiwanese nurses. They worked in many different settings and had a variety of levels of exposure to HIV-positive patients. The findings of this research revealed that most Taiwanese
[A spatial structure model of the basic antigenic determinant of the human immunodeficiency virus type 1 gp120 protein]: Dokl Akad Nauk. 1995 Jun;342(4):543-5. Unique Identifier : AIDSLINE MED/96076046; Andrianov AM; Akhrem AA
The CD4+ T-cell network and the cytokine profile after HIV-1 infection.: Braz J Med Biol Res. 1995 Jan;28(1):2-6. Unique Identifier : AIDSLINE MED/96059246; Caterino-de-Araujo A; Secao de Imunologia, Instituto Adolfo Lutz, Sao Paulo, Brasil.; The present article discusses CD4+ T-cell interaction and cytokine production after HIV-1 infection and progression to AIDS. On the basis of the experience of the author with biological fluids obtained from patients suspected of having AIDS and the recently available data concerning this matter, a model is proposed fo
Detection and isolation of human T-cell leukemia/lymphoma virus type I (HTLV-I) from cultured lymphocytes of a Brazilian TSP/HAM patient.: Braz J Med Biol Res. 1995 Jan;28(1):51-7. Unique Identifier : AIDSLINE MED/96059252; Andrada-Serpa MJ; Araujo AQ; Taffarel M; Schor D; Scheiner MA; Ferreira O; Schatzmayr HG; Secao de Imunologia, Instituto Nacional de Cancer, Rio de; Janeiro, RJ, Brasil.; Some Brazilian regions are considered to be endemic for human T-cell leukemia/lymphoma virus type I (HTLV-I) infection. Several studies have shown a high prevalence of HTLV-I infection among different groups such as blood donors, hemophiliacs and patients suffering from hematological and neurological diseases. Cases o
Low CD4 lymphocyte count in a patient with P. carinii pneumonia after autologous bone marrow transplantation.: Bone Marrow Transplant. 1995 Jun;15(6):977-8. Unique Identifier : AIDSLINE MED/96082729; Castagnola E; Dini G; Lanino E; Tasso L; Dallorso S; Garaventa A; Rossi GA; Giacchino R; Department of Infectious Diseases, G Gaslini Children's Hospital,; Genova, Italy.; Authors report a case of P. carinii pneumonia in a child with 5% CD4 lymphocytes (absolute number 5/microliters) after autologous bone marrow transplantation followed by pulmonary irradiation. Serial evaluation of CD4 lymphocyte count or percentage or, at least, detection of significant and persistent lymphopenia coul
Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity.: Biol Pharm Bull. 1995 Jul;18(7):996-1000. Unique Identifier : AIDSLINE MED/96080767; Inouye Y; Fujimoto Y; Sugiyama M; Yoshida T; Yamase T; Institute of Pharmaceutical Sciences, Hiroshima University School; of Medicine, Japan.; The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB and HIV-1SF-2H). The compounds were
Short-term in vitro culture and molecular analysis of the microsporidian, Enterocytozoon bieneusi.: J Eukaryot Microbiol. 1995 Sep-Oct;42(5):506-10. Unique Identifier : AIDSLINE MED/96010583; Visvesvara G; Leitch GJ; Pieniazek NJ; Da Silva AJ; Wallace S; Slemenda SB; Weber R; Schwartz DA; Gorelkin L; Wilcox CM; et al; Division of Parasitic Diseases, National Center for Infectious; Diseases, Centers for Disease Control and Prevention, Public; Health Service, U.S. Department of Health and Human Services,; Atlanta, Georgia 30341-3724, USA.; The microsporidium, Enterocytozoon bieneusi, causes a severe, debilitating, chronic diarrhea in patients with the acquired immunodeficiency syndrome. Specific diagnosis of intestinal microsporidiosis , especially due to Enterocytozoon, is difficult and there is no known
Small subunit ribosomal DNA phylogeny of various microsporidia with emphasis on AIDS related forms.: J Eukaryot Microbiol. 1995 Sep-Oct;42(5):564-70. Unique Identifier : AIDSLINE GENBANK/M38637; Baker MD; Vossbrinck CR; Didier ES; Maddox JV; Shadduck JA; Department of Entomology, University of Illinois, Urbana 61801,; USA.; Phylogenetic analysis of the small subunit ribosomal DNA of a broad range of representative microsporidia including five species from humans (Enterocytozoon bieneusi, Nosema corneum, Septata intestinalis, Encephalitozoon hellem and Encephalitozoon cuniculi), reveals that human microsporidia are polyphyletic in origin.
Infectious disease testing for blood transfusions.: NIH Consens Statement. 1995 Jan 9-11;13(1):1-27. Unique Identifier : AIDSLINE MED/96071854; OBJECTIVE. To provide physicians and other transfusion medicine professionals with a current consensus on infectious disease testing for blood transfusions. PARTICIPANTS. A non-Federal, nonadvocate, 12-member consensus panel representing the fields of hematology, infectious disease, transfusion medicine, epidemiology,
Ontology-based configuration of problem-solving methods and generation of knowledge-acquisition tools: application of PROTEGE-II to protocol-based decision support.: Artif Intell Med. 1995 Jun;7(3):257-89. Unique Identifier : AIDSLINE MED/96066001; Tu SW; Eriksson H; Gennari JH; Shahar Y; Musen MA; Section on Medical Informatics, Stanford University School of; Medicine, CA 94305-5479, USA.; PROTEGE-II is a suite of tools and a methodology for building knowledge-based systems and domain-specific knowledge-acquisition tools. In this paper, we show how PROTEGE-II can be applied to the task of providing protocol-based decision support in the domain of treating HIV-infected patients. To apply PROTEGE-II, (1)
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1995 Sep 22;5(38):183-4. Unique Identifier : AIDSLINE MED/96019462
SEQHUNT. A program to screen aligned nucleotide and amino acid sequences.: Methods Mol Biol. 1995;51:1-15. Unique Identifier : AIDSLINE MED/96038383; Johnson G; Wu TT; Kabat EA; Department of Biochemistry and Molecular Cell Biology,; Northwestern University, Evanston, IL, USA.
The cost of comprehensive preventive medical services for adolescents.: Arch Pediatr Adolesc Med. 1995 Nov;149(11):1226-34. Unique Identifier : AIDSLINE MED/96049016; Gans JE; Alexander B; Chu RC; Elster AB; Department of Adolescent Health, American Medical Association,; Chicago, Ill, USA.; OBJECTIVES: To address the need for clinical preventive services for 11- to 21-year-old males and females and provide cost estimates for those services under a fee-for-service system. Preventive services include screening, health promotion, and immunizations. DESIGN: The prevalence of adolescent morbidities was derive
[Ileal perforation with CMV enteritis in a newborn infant with acquired immunodeficiency syndrome (letter)]: Arch Pediatr. 1995 Sep;2(9):900. Unique Identifier : AIDSLINE MED/96026480; Maguer D; Bouleau-Desbordes O; Guibert L; Amusini P; Godde F; Delaporte B
Release of hydrogen peroxide from human T cell lines and normal lymphocytes co-infected with HIV-1 and mycoplasma.: Free Radic Res. 1995 Sep;23(3):197-212. Unique Identifier : AIDSLINE MED/96002901; Chochola J; Strosberg AD; Stanislawski M; Departement des Maladies Infectieuses, Parasitaires et; Tropicales, INSERM U313, CHU Pitie-Salpetriere, Paris, France.; Human T-cell lines and normal lymphocytes persistently or acutely co-infected with the human immunodeficiency virus type 1 (HIV-1) and mycoplasmas were found to release hydrogen peroxide (H2O2), a likely cause of oxidative stress in these cells. The spectrofluorometric measurement of H2O2 release from these cells, usi
Gel electrophoretic analysis of cellular and secreted proteins from resting and activated rat alveolar macrophages treated with pentamidine isethionate.: J Chromatogr A. 1995 Sep 22;711(2):331-7. Unique Identifier : AIDSLINE MED/96014393; Selkirk JK; He C; Merrick BA; Laboratory of Molecular Carcinogenesis, National Institute of; Environmental Health Sciences, Research Triangle Park, NC 27709,; USA.; Pneumocystic carinii pneumonia, which is a major cause of death among patients suffering from acquired immunodeficiency syndrome, has often been treated successfully with pentamidine isethionate. This study examines pentamidine effects on cellular and secreted proteins from rat alveolar macrophages by two-dimensional
T cell-rich B cell lymphoma bearing Epstein-Barr virus in tumor cells: a case of IBL-T-like lesion following Lennert's lesion.: Pathol Int. 1995 Jun;45(6):457-62. Unique Identifier : AIDSLINE MED/96086452; Wakatsuki S; Yumoto N; Takagi T; Kurosu K; Sakai C; Tamayama C; Komatsu T; Matsuzaki O; Mikata A; Division of Surgical Pathology, Chiba Cancer Center Hospital,; Japan.; A case of T cell-rich B cell lymphoma (TCRBCL) with Epstein-Barr virus (EBV) infection in tumor cells is reported. A 50 year old male developed right cervical lymph node swelling in July 1988. Initial biopsy in April 1989 demonstrated many scattered Hodgkinoid atypical cells with Lennert s lesion. After partial remiss
Changes in systemic gonadal and adrenal steroids in asymptomatic human immunodeficiency virus-infected men: relationship with the CD4 cell counts.: Eur J Endocrinol. 1995 Oct;133(4):418-24. Unique Identifier : AIDSLINE MED/96038764; Laudat A; Blum L; Guechot J; Picard O; Cabane J; Imbert JC; Giboudeau J; Laboratoire de Biochimie-Hormonologie, Hopital Saint-Antoine,; Paris, France.; Serum sex hormone-binding globulin (SHBG), testosterone, non-SHBG-bound testosterone, androstenedione, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and cortisol were measured in 58 homosexual men seropositive for human immunodeficiency virus (HI
Ribosomal internal transcribed spacer sequences are identical among Mycobacterium avium-intracellulare complex isolates from AIDS patients, but vary among isolates from elderly pulmonary disease patients.: Microbiology. 1995 Oct;141 ( Pt 10):2739-47. Unique Identifier : AIDSLINE GENBANK/X74056; De Smet KA; Brown IN; Yates M; Ivanyi J; MRC Tuberculosis and Related Infections Unit, Hammersmith; Hospital, London, UK.; Sequencing 280 bp of the internal transcribed spacer (ITS) between the 16S and 23S rRNA genes in a collection of 46 clinical isolates of the Mycobacterium avium-intracellulare complex (MAI complex) identified nine different sequences, grouping these isolates in nine ITS sequevars . This analysis extends the subdivisi
HIV-1 gp120 glycoprotein induces [Ca2+]i responses not only in type-2 but also type-1 astrocytes and oligodendrocytes of the rat cerebellum.: Eur J Neurosci. 1995 Jun 1;7(6):1333-41. Unique Identifier : AIDSLINE MED/96073242; Codazzi F; Menegon A; Zacchetti D; Ciardo A; Grohovaz F; Meldolesi J; Department of Pharmacology, Scientific Institute San Raffaele,; Milan, Italy.; Cultures of cerebellar cortex cells were exposed to the HIV-1 envelope glycoprotein, gp120, and investigated for cytosolic Ca2+ ion concentration ([Ca2+]i) changes by the fura-2 ratio videoimaging technique while bathed in complete, Na(+)-free or Mg(2+)-free Krebs-Ringer media. At the end of the [Ca2+]i experiments th
Exposure to gp120 of HIV-1 induces an increased release of arachidonic acid in rat primary neuronal cell culture followed by NMDA receptor-mediated neurotoxicity.: Eur J Neurosci. 1995 Jun 1;7(6):1353-9. Unique Identifier : AIDSLINE MED/96073244; Ushijima H; Nishio O; Klocking R; Perovic S; Muller WE; Institute of Public Health, Tokyo, Japan.; After incubation of highly enriched neurons from rat cerebral cortex with the HIV-1 coat protein gp120 for 18 h, cells showed fragmentation of DNA at internucleosomal linkers followed by NMDA receptor-mediated neurotoxicity. We report that in response to exposure to gp120 cells react with an increased release of arach
Empiric diagnosis of Pneumocystis carinii pneumonia. Questions of accuracy and equity [editorial; comment]: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1433-4. Unique Identifier : AIDSLINE MED/96048793; Glassroth J
Relationship between procedures and health insurance for critically ill patients with Pneumocystis carinii pneumonia [see comments]: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1435-42. Unique Identifier : AIDSLINE MED/96048794; Horner RD; Bennett CL; Rodriguez D; Weinstein RA; Kessler HA; Dickinson GM; Johnson JL; Cohn SE; George WL; Gilman SC; et al; Division of Health Services Research, Durham Veterans; Administration Hospital, NC, USA.; The objective of the present study was to assess the association between type of health insurance coverage and use of diagnostic tests and therapies among patients with AIDS-related Pneumocystis carinii pneumonia (PCP). Fifty-six private, public, and community hospitals in Chicago, Los Angeles, and Miami were selected
GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome.: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1549-54. Unique Identifier : AIDSLINE MED/96048812; Villard J; Dayer-Pastore F; Hamacher J; Aubert JD; Schlegel-Haueter S; Nicod LP; Department of Medicine, Hopital Cantonal Universitaire, Geneva,; Switzerland.; Polymorphonuclear leukocytes (PMN) are the predominant inflammatory cells recruited in acute lung injury. This study compares the concentration of interleukin-8 (IL-8) to those of GRO alpha, both of which are CXC chemokines, in bronchoalveolar lavage fluid (BALF) in three acute pathologic states: bacterial pneumonia (
Clinical isolates of Mycobacterium simiae in San Antonio, Texas. An 11-yr review.: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1555-7. Unique Identifier : AIDSLINE MED/96048813; Valero G; Peters J; Jorgensen JH; Graybill JR; Department of Infectious Diseases, University of Texas Health; Science Center at San Antonio 78284-7870, USA.; During a period of 11 yr (1983-1993) 137 clinical isolates of Mycobacterium simiae obtained from 75 patients were identified in a University hospital in San Antonio, Texas. One hundred twenty-eight isolates (93%) were from a pulmonary source, four (3%) from blood, and five from other sites including skin, urine, lymph
Clinical and chest radiographic features of tuberculosis associated with human immunodeficiency virus in Zimbabwe.: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1558-61. Unique Identifier : AIDSLINE MED/96048814; Pozniak AL; MacLeod GA; Ndlovu D; Ross E; Mahari M; Weinberg J; Department of Medicine, University of Zimbabwe, Harare, Zimbabwe.; In the developing world, the diagnosis of tuberculosis is dependent on clinical and radiologic features as culture facilities are not readily available. It has been reported that tuberculosis in HIV-positive persons can present with atypical clinical and radiographic features. The object of this study was to examine h
Laboratory contamination of Mycobacterium tuberculosis cultures.: Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1702-4. Unique Identifier : AIDSLINE MED/96048836; Dunlap NE; Harris RH; Benjamin WH Jr; Harden JW; Hafner D; Department of Microbiology, University of Alabama at Birmingham,; USA.; The purpose of this study was to investigate possible laboratory contamination of Mycobacterium tuberculosis cultures which resulted in the misdiagnosis of tuberculosis. We have investigated three cases in which a patient s culture was positive for M. tuberculosis but there was not a high clinical suspicion for diseas
[African histoplasmosis due to Histoplasma capsulatum var. duboisii: relationship with AIDS in recent Congolese cases]: Sante. 1995 Jul-Aug;5(4):227-34. Unique Identifier : AIDSLINE MED/96016648; Chandenier J; Goma D; Moyen G; Samba-Lefebvre MC; Nzingoula S; Obengui; Mbitsi A; Nkiwabonga L; Ngaporo AI; Service de parasitologie-mycologie, CHU de Brazzaville, Congo.; Six new cases are described for African histoplasmosis, Histoplasma capsulatum var. duboisii, from Congo. The first was an HIV sero-negative child who has been monitored for the last three years. While under treatment with ketoconazole, amphotericin B, and finally itraconazole, the development of the infection was acc
[African women and AIDS: the right to know and the right to live as a seropositive]: Sante. 1995 Jul-Aug;5(4):259-61. Unique Identifier : AIDSLINE MED/96016653; Kerouedan D; Programme national de lutte contre le Sida Cote d'Ivoire.
[Leishmaniasis: new diagnostic approaches]: Sante. 1995 Jul-Aug;5(4):262. Unique Identifier : AIDSLINE MED/96016654; Robert F
[Current methods of immunological and genetic diagnosis of HIV infection (literature review)]: Klin Lab Diagn. 1995 Sep-Oct;(5):12-6. Unique Identifier : AIDSLINE MED/96046064; Dmitriev VI; Kuz'min AN
Disseminated cutaneous Cryptococcus clinically mimicking basal cell carcinoma [letter]: Dermatol Surg. 1995 Nov;21(11):992-3. Unique Identifier : AIDSLINE MED/96046804; Murakawa GJ; Mauro TM; Egbert B
Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.: Transpl Immunol. 1995 Jun;3(2):124-34. Unique Identifier : AIDSLINE MED/96103421; Lagoo-Deenadayalan S; Lagoo AS; Lemons JA; Lorenz HM; Bass JD; McDaniel DO; Hardy KJ; Barber WH; Department of Surgery, University of Mississippi Medical Center,; Jackson 39216, USA.; Previous studies have shown that post-transplantation infusion of donor specific bone marrow following a non-specific potent immunosuppressive agent such as antilymphocyte globulin (ALG) can significantly enhance graft survival compared to ALG alone. This enhancement remains variable and is thought to occur through th
Lithium and anti-viral drug toxicity: II. Further studies on the ability of lithium to modulate the hematopoietic toxicity associated with the anti-viral drug zidovudine (AZT).: Rom J Physiol. 1993 Jul-Dec;30(3-4):231-9. Unique Identifier : AIDSLINE MED/96078488; Kazim S; Townsley L; Hughes NK; Tse KF; Ling J; Scott K; Birch NJ; Gallicchio VS; School of Health Sciences, University of Wolverhampton, UK.; Lithium is an agent capable of influencing many aspects of blood cell production, in particular, the formation of granulocytes. Because of this property, lithium has been demonstrated to be an effective agent whenever granulocyte production is either faulty or inadequate. The anti-viral drug zidovudine (
Disseminated disease due to Mycobacterium avium complex in AIDS.: QJM. 1995 Sep;88(9):617-26. Unique Identifier : AIDSLINE MED/96030957; Flegg PJ; Laing RB; Lee C; Harris G; Watt B; Leen CL; Brettle RP; Regional Infectious Diseases Unit, City Hospital, Edinburgh, UK.; We retrospectively analysed 46 cases of disseminated infection with Mycobacterium avium complex (MAC) within a cohort of 702 HIV-infected patients in Edinburgh. Clinical features were compared with case-matched controls (AIDS cases without disseminated MAC), and survival and progression times were controlled for confo
HIV-associated renal disease in London hospitals.: QJM. 1995 Sep;88(9):627-34. Unique Identifier : AIDSLINE MED/96030958; Connolly JO; Weston CE; Hendry BM; Department of Medicine, King's College Hospital School of; Medicine and Dentistry, London, UK.; We report experience from London hospitals which further illustrates the heterogeneous nature of HIV-associated nephropathy (HIVAN). Nineteen HIV-positive patients underwent renal biopsy from 1992 to 1994. Fourteen were male, five female. Eleven were Afro-Caribbean, 7 Caucasian and 1 Asian. Eleven patients had classic
AIDS. Viruses, cytokines and Kaposi's sarcoma.: Curr Biol. 1995 May 1;5(5):469-71. Unique Identifier : AIDSLINE MED/96059362; Ganem D; Howard Hughes Medical Institute, Departmentof Microbiology,; University of California Medical Center, San Francisco 94143,; USA.; HIV infection strongly predisposes people to Kaposi s sarcoma, a complex proliferative lesion driven by autocrine and paracrine cytokine expression; new evidence implicates a second virus in the etiology of the disease.
RAW264 macrophages stably transfected with an HIV-1 LTR reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated with lipopolysaccharide, TNF-alpha or taxol.: J Inflamm. 1995;45(2):126-35. Unique Identifier : AIDSLINE MED/96050094; Sweet MJ; Hume DA; Centre for Molecular and Cellular Biology, University of; Queensland, Brisbane, Australia.; Bacterial lipopolysaccharide (LPS) modulates expression of a variety of genes in macrophages, and additionally activates viral promoters including the HIV-1 LTR. The HIV-1 LTR driving the luciferase reporter gene was stably transfected into the murine macrophage cell line, RAW264. In stably transfected cells, lucifera
Superantigen toxic shock syndrome toxin-1 (TSST-1) enhances the replication of HIV-1 in peripheral blood mononuclear cells through selective activation of CD4+ T lymphocytes.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):393-9. Unique Identifier : AIDSLINE MED/96074271; Hashimoto K; Shigeta S; Baba M; Department of Microbiology, Fukushima Medical College, Japan.; Staphylococcus aureus has been recognized as a common cause of bacteremia of such infections in human immunodeficiency virus type 1 (HIV-1)-seropositive patients. Some staphylococcal exotoxins are recognized as superantigens. We have found that superantigen toxic shock syndrome toxin-1 (TSST-1) brings about a high lev
Neutralizing antibodies in slowly progressing HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):400-7. Unique Identifier : AIDSLINE MED/96074272; Schonning K; Nielsen C; Iversen J; Nielsen JO; Hansen JE; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; Ten asymptomatic individuals who had experienced only limited CD4+ cell loss after prolonged infection with HIV-1 were studied. These individuals had a mean CD4+ cell count of 674 x 10(6) cells/L and a mean duration of infection of 8.5 years. Also included were 10 asymptomatic HIV-1-infected individuals who, over a si
Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):408-16. Unique Identifier : AIDSLINE MED/96074273; Re MC; Furlini G; Vignoli M; Ramazzotti E; Roderigo G; De Rosa V; Zauli G; Lolli S; Capitani S; La Placa M; Institute of Microbiology, University of Bologna Medical School,; St. Orsola General Hospital, Italy.; In HIV-1-infected cell cultures, a relatively low concentration (5 micrograms/ml) of monoclonal antibody (mAb) against HIV-1-transactivating Tat protein was an efficient inhibitor of HIV-1 replication both in HIV-1(IIIB)-infected Jurkat cell and peripheral blood mononuclear cell (PBMC) cultures and significantly reduc
Inhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):417-24. Unique Identifier : AIDSLINE MED/96074274; Heinkelein M; Schneider-Schaulies J; Walker BD; Jassoy C; Institute for Virology and Immunobiology, Wurzburg University,; Germany.; HIV-specific cytotoxic T lymphocytes (CTLs) are an important component of the host immune response against HIV infection, and these cells release a variety of cytokines when they meet their target antigen. Since the phosphodiesterase inhibitor pentoxifylline is being used as a therapeutic agent in clinical trials of H
Quantifying HIV-1 RNA using the polymerase chain reaction on cerebrospinal fluid and serum of seropositive individuals with and without neurologic abnormalities.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):425-35. Unique Identifier : AIDSLINE MED/96074275; Conrad AJ; Schmid P; Syndulko K; Singer EJ; Nagra RM; Russell JJ; Tourtellotte WW; Neurology Services, VA Medical Center West Los Angeles,; California 90073, USA.; We quantified HIV-1 RNA levels (copies per milliliter) in cerebrospinal fluid (CSF) and serum from subjects at various stages of HIV-1 disease and determined the relationship of RNA levels to clinical and neurologic disease status (HND) and to laboratory values. Ninety-seven HIV-1-seropositive men without CNS opportun
PCR analysis of HIV-seronegative, heterosexual partners of HIV-infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):436-40. Unique Identifier : AIDSLINE MED/96074276; Palumbo P; Skurnick J; Lewis D; Eisenberg M; Department of Pediatrics, University of Medicine and Dentistry,; New Jersey Medical School, Newark 07103, USA.; A cohort of human immunodeficiency virus (HIV)-discordant couples was established to evaluate risk factors associated with heterosexual viral transmission. Polymerase chain reaction (PCR) was utilized to document the HIV-uninfected status among members of discordant heterosexual couples and to rule out immunosilent in
Zygomycosis (mucormycosis) and HIV infection: report of three cases and review.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):441-9. Unique Identifier : AIDSLINE MED/96074277; Nagy-Agren SE; Chu P; Smith GJ; Waskin HA; Altice FL; Department of Medicine, Yale University School of Medicine, New; Haven, Connecticut 06510, USA.; We report three cases of zygomycosis (mucormycosis) occurring in three individuals infected with the human immunodeficiency virus (HIV) and review 12 other published cases. We present the only two case reports of disseminated zygomycosis in AIDS patients, and the only AIDS patient with renal zygomycosis to survive wit
The 90K tumor-associated antigen and clinical progression in human immunodeficiency virus infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):450-6. Unique Identifier : AIDSLINE MED/96074278; Iacobelli S; Ullrich A; Tinari N; Ortona L; Tamburrini E; D'Egidio M; Ghinelli F; Sighinolfi L; Piazza M; Chirianni A; et al; University G. D'Annunzio Medical School, Chieti, Italy.; We investigated the possibility that a secreted glycoprotein of approximately 90,000 daltons, termed 90K and identified as a member of the protein superfamily characterized by the scavenger receptor cysteine-rich (SRCR) domain, might have value as a predictor of progression to acquired immunodeficiency syndrome (AIDS)
Comparison of the declines in CD4 counts in HIV-1-seropositive female sex workers and women from the general population in Nairobi, Kenya.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):457-61. Unique Identifier : AIDSLINE MED/96074279; Bwayo JJ; Nagelkerke NJ; Moses S; Embree J; Ngugi EN; Mwatha A; Kimani J; Anzala A; Choudhri S; Achola JO; et al; Department of Medical Microbiology, University of Nairobi, Kenya.; Studies from Kenya have reported rapid clinical disease progression among HIV-infected professional sex workers. The reasons for this rapid decline are unknown. To better understand factors influencing the course of disease, HIV-1 disease progression was explored in terms of decline
CD4+ and CD8+ lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):462-70. Unique Identifier : AIDSLINE MED/96074280; Caruso A; Canaris AD; Licenziati S; Cantalamessa A; Folghera S; Lonati MA; de Panfilis G; Garotta G; Turano A; Institute of Microbiology, University of Brescia, Italy.; Individual cells capable of interferon-gamma (IFN-gamma) synthesis are easily detected by immunofluorescence and flow cytometric analysis using an anti-IFN-gamma monoclonal antibody as specific reagent. By IFN-gamma flow cytometry assay, we demonstrated that HIV-seropositive patients, starting at the early stage of vi
Evidence for a shift from a type I lymphocyte pattern with HIV disease progression. Hemophilia Growth and Development Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):471-6. Unique Identifier : AIDSLINE MED/96074281; Jason J; Sleeper LA; Donfield SM; Murphy J; Warrier I; Arkin S; Evatt B; Division of HIV (AIDS), National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Public Health; Service, U.S. Department of Health and Human Services, Atlanta,; Georgia 30333, USA.; Whether a shift from a type I (cell mediated) immune profile occurs with progressive HIV-related immune dysfunction is a matter of heated debate. We analyzed data for 333 HIV antibody-positive (HIV+) and -negative (HIV-) hemophilic children/adolescents, to examine whether the relationships among immunologic parameters
Dynamics of risk behavior for HIV infection among young Thai men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):477-83. Unique Identifier : AIDSLINE MED/96074282; Celentano DD; Nelson KE; Suprasert S; Eiumtrakul S; Galai N; Kuntolbutra S; Wright N; Theetranont C; Department of Health Policy and Management, Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA.; The objective of this investigation was to analyze the dynamics of risk for HIV-1 infection among young men in Thailand . We conducted a prospective study in a cohort (n = 1,236) of young men, aged 19-23 years at conscription into the Royal Thai Army and Air Force from six provinc
Accuracy of a saliva test for HIV antibody [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):484-5. Unique Identifier : AIDSLINE MED/96074283; Frerichs RR
Recent trends in Pneumocystis carinii pneumonia as AIDS-defining disease in nine European countries [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):485-6. Unique Identifier : AIDSLINE MED/96074284; Hoover DR
Seroprevalence of HIV-1 among pregnant women at Recife, northeastern Brazil [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):486-7. Unique Identifier : AIDSLINE MED/96074285; Souza E da S; Figueira F de S; da Silva GA; Vilarim JA; de Souza AI; Pessoa VP; Cavalcanti AS; Dantas MC; Oliveira MJ; Cordeiro MT
A defective HIV-1 vector for gene transfer to human lymphocytes.: J Mol Med. 1995 Jun;73(6):279-88. Unique Identifier : AIDSLINE MED/96083254; Parolin C; Sodroski J; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115, USA.
[Role of regional health observation posts: structure, operation, actions]: Bull Acad Natl Med. 1995 May;179(5):941-8; discussion 949-50. Unique Identifier : AIDSLINE MED/96005230; Garros B; The ORS were established at the beginning of 1980 s to improve and to promote health informations to help decision makers. The ORS are non-profit making institutions supported by Health Ministry and local authorities. They also conclude contracts with private or public partners. A national federation exist since 1988.
Predictors of high and low levels of HIV risk behavior among adults with chronic mental illness.: Psychiatr Serv. 1995 Aug;46(8):813-8. Unique Identifier : AIDSLINE MED/96068232; Kelly JA; Murphy DA; Sikkema KJ; Somlai AM; Mulry GW; Fernandez MI; Miller JG; Stevenson LY; Department of psychiatry and behavioral medicine, Medical College; of Wisconsin, Milwaukee 53226, USA.; OBJECTIVE: Several recent studies confirm elevated rates of human immunodeficiency virus infection among acute and chronic mentally ill adults in large urban areas. This research sought to characterize risk for HIV infection among adults with chronic mental illness and to examine psychosocial factors predictive of ris
IgE levels in pediatric HIV-1 infection.: Ann Allergy Asthma Immunol. 1995 Oct;75(4):332-6. Unique Identifier : AIDSLINE MED/96026133; Ellaurie M; Rubinstein A; Rosenstreich DL; Children's National Medical Center, Special Immunology Service,; Washington, DC, USA.; BACKGROUND: Atopic symptoms such as sinusitis, eczema, and wheezing are common in human immunodeficiency virus (HIV)-infected children. OBJECTIVE: To determine whether IgE levels are increased in HIV-seropositive children, and to determine whether there is a relationship between IgE, stage of disease, and atopic sympt
Oral fluid as a specimen for detection and confirmation of antibodies to human immunodeficiency virus type 1.: Clin Diagn Lab Immunol. 1995 Jul;2(4):395-9. Unique Identifier : AIDSLINE MED/96082412; Granade TC; Phillips SK; Parekh B; Pau CP; George JR; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Paired serum and oral fluid specimens (n = 287) were collected with the Omni-Sal device and were assayed for the presence of antibodies to human immunodeficiency virus type 1 (HIV-1). Enzyme immunoassays (EIAs)--Abbott 3A11, an Organon Teknika Corporation research-use-only test, and the Murex GACELISA--were used per t
Presence of neutralizing antibodies to heterologous human immunodeficiency virus type 1 isolates in sera of infected individuals is not predictive of rate of disease progression.: Clin Diagn Lab Immunol. 1995 Jul;2(4):400-3. Unique Identifier : AIDSLINE MED/96082413; Warren RQ; Wong MT; Melcher GP; Blatt SP; Zapiola I; Bouzas MB; Muchinik G; Anderson SA; Kennedy RC; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78228, USA.; These studies were undertaken to examine whether the presence of human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies in sera of infected individuals would alter the rate of disease progression. HIV-1-infected individuals (n = 87) were initially examined for neutralizing activity in vitro against both l
Decreased T-cell proliferative response to common environmental antigens could be an indicator of early human immunodeficiency virus-mediated lymphocyte lesions.: Clin Diagn Lab Immunol. 1995 Jul;2(4):404-7. Unique Identifier : AIDSLINE MED/96082414; Tassinari P; Deibis L; Blanca I; Bianco NE; Echeverria de Perez G; Instituto de Inmunologia, Facultad de Medicina, Universidad; Central de Venezuela, Caracas.; To evaluate CD4+/CD29+ cells and their responses to different antigens in polar stages of human immunodeficiency virus (HIV) infection, we studied 26 HIV-seropositive carriers (SPCs) and 15 patients with AIDS simultaneously with 20 healthy volunteers (HVs) and 10 seronegative homosexual and bisexual men (SNH). CD3, CD
Reversal of immunosuppression of lymphocyte proliferation caused by sera from persons with AIDS.: Clin Diagn Lab Immunol. 1995 Jul;2(4):408-11. Unique Identifier : AIDSLINE MED/96082415; Tomar RH; John P; Hinds P; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison, USA.; Sera from persons with AIDS contain inhibitors of lymphocyte proliferation. Inhibitory activity can be detected before the development of AIDS in humans. There appear to be at least three distinct suppressive moieties, one of which is prostaglandin E2. We and others had previously shown that serum samples from subject
Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates.: Clin Diagn Lab Immunol. 1995 Jul;2(4):434-8. Unique Identifier : AIDSLINE MED/96082419; Nair MP; Chadha KC; Stadler I; Sweet A; Schwartz SA; Department of Medicine and Microbiology, State University of New; York at Buffalo, USA.; While considerable progress in examining the course of human immunodeficiency virus (HIV) infection in adults has been made, a better understanding of the natural history of perinatal HIV infection remains to be obtained. Dysregulation of the production and functions of various cytokines, especially the interferons (I
Age-dependent humoral responses of children to mycobacterial antigens.: Clin Diagn Lab Immunol. 1995 Jul;2(4):443-7. Unique Identifier : AIDSLINE MED/96082421; Fairchok MP; Rouse JH; Morris SL; Walter Reed Army Medical Center, Washington, D.C. 20307-5000,; USA.; In the United States , disseminated infection with environmental mycobacteria, including the Mycobacterium avium complex, is the most common opportunistic bacterial infection seen in AIDS patients. However, the source and relative degree of exposure to environmental mycobacteria during
Anti-human immunodeficiency virus type 1 antibodies of noninfected subjects are not related to autoantibodies occurring in systemic diseases.: Clin Diagn Lab Immunol. 1995 Jul;2(4):458-61. Unique Identifier : AIDSLINE MED/96082424; Kammerer R; Burgisser P; Frei PC; Division of Immunology and Allergy, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.; Indeterminate Western blot (WB) (immunoblot) patterns for anti-human immunodeficiency virus type 1 (HIV-1) antibodies are often observed when testing serum samples from noninfected individuals. We investigated here the possible involvement of some frequently occurring autoantibodies (anti-SmB/B , U1snRNP [68 kDa, A, a
Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group.: Clin Diagn Lab Immunol. 1995 Jul;2(4):462-8. Unique Identifier : AIDSLINE MED/96082425; Landay AL; Brambilla D; Pitt J; Hillyer G; Golenbock D; Moye J; Landesman S; Kagan J; Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois; 60612, USA.; Recent studies have demonstrated the utility of measuring subsets of CD8+ T cells as prognostic markers in epidemiology cohort studies of human immunodeficiency virus (HIV)-infected patients. Most of these studies evaluating the value of CD8+ T-cell subsets have been performed at single centers, and few data are avail
Early appearance of antibodies to simian immunodeficiency virus in saliva and serum of infected macaques.: Clin Diagn Lab Immunol. 1995 Jul;2(4):489-91. Unique Identifier : AIDSLINE MED/96082431; Meiller TF; Narayan O; Joag SV; Overholser CD Jr; Baltimore College of Dental Surgery, Dental School, University of; Maryland 21201, USA.; Simian immunodeficiency virus (SIV) infection in macaques is an important animal model for human immunodeficiency virus infection in humans. This study evaluated the temporal development of antibodies to SIV in the parotid saliva of macaques inoculated with the virus and compared these findings with the development of
Biliary infections.: Curr Opin Gen Surg. 1993;:265-70. Unique Identifier : AIDSLINE MED/96050662; Roslyn JJ; Medical College of Pennsylvania, Philadelphia, USA.; The scope and importance of biliary infections from both a clinical and scientific perspective is rapidly changing. During this past year, considerable attention in the literature has focused on infections that are increasing in frequency in the United States and throughout the world,
Multi-gene family of major surface glycoproteins of Pneumocystis carinii: full-size cDNA cloning and expression.: DNA Res. 1994;1(2):57-66. Unique Identifier : AIDSLINE GENBANK/D17440; Kitada K; Wada M; Nakamura Y; Department of Tumor Biology, University of Tokyo, Japan.; The major surface glycoprotein (MSG) of Pneumocystis carinii plays a crucial role in the fatal pneumonia caused by this organism in AIDS patients. A cDNA encoding a full-length MSG polypeptide was isolated from a lambda library of rat-derived P. carinii cDNAs. The deduced MSG, referred to as the MSG5 subtype, is a 120
Progress towards gene therapy for HIV infection.: Gene Ther. 1994 Jan;1(1):13-26. Unique Identifier : AIDSLINE MED/96050915; Yu M; Poeschla E; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; The retroviral life cycle and genetic plasticity of human immunodeficiency virus 1 (HIV-1) present unprecedented therapeutic challenges. Twelve years into the HIV epidemic, satisfactory treatment remains elusive. Our current understanding of AIDS pathogenesis calls for early intervention with antiviral agents. Althoug
Rapid protection against human immunodeficiency virus type 1 (HIV-1) replication mediated by high efficiency non-retroviral delivery of genes interfering with HIV-1 tat and gag.: Gene Ther. 1994 Jan;1(1):27-31. Unique Identifier : AIDSLINE MED/96050916; Lori F; Lisziewicz J; Smythe J; Cara A; Bunnag TA; Curiel D; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; Efficient transduction of inhibitory genes is a critical requirement in the development of a gene therapy strategy against human immunodeficiency virus type 1 (HIV-1). Commonly used systems based on retrovirus-mediated gene delivery are characterized by low efficiency gene transfer into the target cell. Genes were tra
Regulated expression of a dominant negative form of Rev improves resistance to HIV replication in T cells.: Gene Ther. 1994 Jan;1(1):32-7. Unique Identifier : AIDSLINE MED/96050917; Liu J; Woffendin C; Yang ZY; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Department of Internal Medicine, Ann Arbor 48109-0650,; USA.; Infection by the human immunodeficiency virus (HIV) has remained refractory to treatment, and molecular genetic interventions have been developed for the treatment of the acquired immunodeficiency syndrome (AIDS). Previous studies have focused on the development of gene products which inhibit productive HIV replicatio
Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1.: Gene Ther. 1994 Jan;1(1):38-45. Unique Identifier : AIDSLINE MED/96050918; Yamada O; Yu M; Yee JK; Kraus G; Looney D; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; T-cell lines (Jurkat and Molt-4) were transduced with retroviral vectors containing a hairpin ribozyme that targets a conserved sequence in the 5 transcribed leader sequence of human immunodeficiency virus (HIV) type 1. Stable cell lines were generated which constitutively and persistently expressed the ribozyme gene
Versatile retroviral vectors for potential use in gene therapy.: Gene Ther. 1994 Mar;1(2):136-8. Unique Identifier : AIDSLINE MED/96050932; Hawley RG; Lieu FH; Fong AZ; Hawley TS; Division of Cancer Research, Sunnybrook Health Science Centre,; Toronto, Ontario, Canada.; A set of retroviral vectors is described whose capacity for high efficiency transduction of functional genes into undifferentiated murine embryonic and haematopoietic cells makes them ideally suited for preclinical studies with murine models. Multiple unique cloning sites permit insertion of genes into the vectors suc
Block of HIV-1 infection by a combination of antisense tat RNA and TAR decoys: a strategy for control of HIV-1.: Gene Ther. 1994 May;1(3):208-16. Unique Identifier : AIDSLINE MED/96050942; Chang HK; Gendelman R; Lisziewicz J; Gallo RC; Ensoli B; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA.; The tat gene product (Tat) of HIV-1 is an early regulatory protein necessary for viral gene expression and replication. Tat may also play a role as an extracellular protein in both HIV-1 replication and AIDS-associated disorders such as Kaposi s sarcoma. Thus, Tat represents a good target for gene therapy against AIDS
Cell targeting with retroviral vector particles containing antibody-envelope fusion proteins.: Gene Ther. 1994 Sep;1(5):292-9. Unique Identifier : AIDSLINE MED/96050953; Chu TH; Martinez I; Sheay WC; Dornburg R; UMDNJ/Robert Wood Johnson Medical School, Department of; Microbiology, Piscataway 08854, USA.; Retroviral vectors are the most efficient tool to introduce genes into vertebrate cells. However, their use is limited by the host range of the retrovirus from which they were derived. To alter the host range of the vector particle, we developed a method to substitute the receptor-binding domain of the envelope protei
A new reporter system for detection of retroviral infection.: Gene Ther. 1995 Aug;2(6):369-76. Unique Identifier : AIDSLINE MED/96002912; Planelles V; Haislip A; Withers-Ward ES; Stewart SA; Xie Y; Shah NP; Chen IS; Department of Medicine, UCLA School of Medicine, USA.; We describe a novel reporter molecule, the murine surface antigen Thy-1, useful for immunoselection and detection of retrovirus-mediated transduction by flow cytometry. A cDNA encoding the murine thy-1 gene was isolated, and cell surface expression of its gene product was demonstrated. The Thy-1 glycoprotein was teste
Inhibition of HIV-1 in CEM cells by a potent TAR decoy.: Gene Ther. 1995 Aug;2(6):377-84. Unique Identifier : AIDSLINE MED/96002913; Lee SW; Gallardo HF; Gaspar O; Smith C; Gilboa E; Program of Molecular Biology, Memorial Sloan-Kettering Cancer; Center, New York, NY 10021, USA.; TAR decoys are short RNA oligonucleotides, corresponding to the HIV TAR sequence, which inhibit HIV expression and replication by blocking the binding of the HIV regulatory protein Tat to the authentic TAR region. In previous studies, TAR decoys expressed from a tRNA polIII promoter were moderately effective at inhibi
Increased titer of recombinant AAV vectors by gene transfer with adenovirus coupled to DNA-polylysine complexes.: Gene Ther. 1995 Aug;2(6):429-32. Unique Identifier : AIDSLINE MED/96002920; Mamounas M; Leavitt M; Yu M; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; One of the principal problems with using recombinant adeno-associated virus vectors (rAAV) as vehicles for gene delivery has been the difficulty in obtaining high-titer virus stocks after the initial transfection into producer cells. In this report we describe a method for transfecting cells at extremely high efficien
Evaluation of retroviral vectors based on the gibbon ape leukemia virus.: Gene Ther. 1995 Sep;2(7):486-92. Unique Identifier : AIDSLINE MED/96050909; Eglitis MA; Schneiderman RD; Rice PM; Eiden MV; Unit of Molecular Virology, National Institute of Mental Health,; Bethesda, MD 20892-4068, USA.; The gibbon ape leukemia viruses (GaLVs) are primate-derived C-type retroviruses with a broad host range. Using an infectious, full-length clone of the GaLV SEATO strain, we have determined that this virus replicates efficiently in 13 of 17 human cell lines tested. In fact, the SB lymphoblast cell line, while resistant
Low avidity recognition of self-antigen by T cells permits escape from central tolerance.: Immunity. 1995 Oct;3(4):407-15. Unique Identifier : AIDSLINE MED/96036617; Liu GY; Fairchild PJ; Smith RM; Prowle JR; Kioussis D; Wraith DC; Cambridge University Department of Pathology, England.; The immunodominant epitope of myelin basic protein, Ac1-9, is encephalitogenic in H-2u mice. We have previously demonstrated that this epitope displays low affinity for I-Au and have suggested that the avidity of T cell recognition in the thymus may be compromised, enabling autoreactive T cells to escape self-toleranc
Tissue-specific targeting of cytokine unresponsiveness in transgenic mice.: Immunity. 1995 Nov;3(5):657-66. Unique Identifier : AIDSLINE MED/96074241; Dighe AS; Campbell D; Hsieh CS; Clarke S; Greaves DR; Gordon S; Murphy KM; Schreiber RD; Center for Immunology, Washington University School of Medicine,; St. Louis, Missouri 63110, USA.; The ubiquitous cellular distribution of certain cytokine receptors has hampered attempts to define the physiologically important cell-specific functions of cytokines in vivo. Herein, we report the generation of transgenic mice that express a dominant-negative IFN gamma receptor alpha chain mutant under the control of
Testing HIV molecular biology in in silico physiologies.: Ismb. 1993;1:354-61. Unique Identifier : AIDSLINE MED/96038985; Sieburg HB; Baray C; Kunzelman KS; Department of Psychiatry, University of California, San Diego; 92093-0603, USA.; The natural and medical sciences have strongly benefitted from technological advances that help to create and store more raw information than can be effectively processed. In particular, this rapid growth has created a strong need for a flexible and far-reaching approach to cross-database simulation. The paper uses a
The status of HIV/AIDS vaccines--1993.: Ther Immunol. 1994 Apr;1(2):95-100. Unique Identifier : AIDSLINE MED/96053293; Weber J; St Mary's Hospital Medical School, Paddington, London, UK.
The effects of FK506 and dexamethasone on rat thymocyte differentiation.: Ther Immunol. 1994 Jun;1(3):135-41. Unique Identifier : AIDSLINE MED/96053297; Tsuchida M; Takai K; Jojima K; Naito K; Fujikura Y; Fukumoto T; Department of Urology, Yamaguchi University School of Medicine,; Japan.; We investigated the effects of FK506 and glucocorticoids (GC) on rat thymocytes using flow cytofluorometry. Rats were treated with GC (0.1 mg/body, by single injection), with FK506 (1 mg/kg/day, for 7 days), or with FK506 and GC. GC alone significantly decreased the percentage of CD4+8+ thymocytes and increased the pe
Interleukin-10 and its receptor.: Ther Immunol. 1994 Jun;1(3):173-85. Unique Identifier : AIDSLINE MED/96053301; Ho AS; Moore KW; Department of Immunology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94306, USA.; The cytokine interleukin-10 (IL-10) has several important activities on cells of the immune system. IL-10 profoundly suppresses activation of macrophages, inhibiting their ability to secrete cytokines and serve as accessory cells for stimulation of T cell and natural killer (NK) cell function. IL-10 also plays a role
Anti-CD4 activity of normal human immunoglobulin G for therapeutic use. (Intravenous immunoglobulin, IVIg).: Ther Immunol. 1994 Oct;1(5):269-77. Unique Identifier : AIDSLINE MED/96053309; Hurez V; Kaveri SV; Mouhoub A; Dietrich G; Mani JC; Klatzmann D; Kazatchkine MD; INSERM U 28, Hopital Broussais, Paris, France.; The effects of intravenously administered normal immunoglobulin G (IVIg) in autoimmune diseases are dependent on the ability of IVIg to interact with surface molecules of lymphocytes. In the present study, we demonstrate the presence of anti-CD4 activity in IVIg by showing the ability of IVIg to bind to CD4 and to inh
Role of cell-mediated immunity in bovine leukemia virus (BLV) infection in ruminants: its implication for the vaccination strategy against retroviruses.: Ther Immunol. 1994 Oct;1(5):297-301. Unique Identifier : AIDSLINE MED/96053312; Sugimoto M; Ohishi K; Ikawa Y; Department of Preventive Medicine, Nagasaki University, Japan.; Recent studies in the immunopathogenesis of bovine leukemia virus (BLV) infection in ruminants, reviewed herein, provide an insight into the vaccination strategy against retrovirus infection. It was shown that vaccination of naive sheep with a recombinant vaccinia virus (RVV) expressing BLV envelope glycoprotein prote
Cytokine expression in large cell lymphoma associated with acquired immunodeficiency syndrome.: J Interferon Cytokine Res. 1995 Mar;15(3):261-8. Unique Identifier : AIDSLINE MED/96075715; Marsh JW; Herndier B; Tsuzuki A; Ng VL; Shiramizu B; Abbey N; McGrath MS; Department of Medicine, University of California, San Francisco; 94110, USA.; Cytokine expression was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) in a retrospective sampling of 16 AIDS-associated large cell lymphomas (LCL). IL-6 receptor (IL-6R) and IL-10 expression was detected in a majority of the tumor specimens tested, IL-6 expression was detected in 5 of 16 lymphom
Screening and empiric treatment for syphilis in an inner-city emergency department.: Acad Emerg Med. 1995 Sep;2(9):765-72. Unique Identifier : AIDSLINE MED/96026567; Ernst AA; Farley TA; Martin DH; Department of Medicine, Louisiana State University, Charity; Hospital, New Orleans 70140, USA.; OBJECTIVE: To examine targeted screening and empiric treatment for syphilis in an urban ED. METHODS: Screening of emergency patients during previously arranged shifts from July 1991 through January 1992 in a university-affiliated, inner-city ED. Emergency patients who perceived that they had high-risk factors for syph
HIV seroprevalence in emergency department patients: Portland, Oregon, 1988-1991.: Acad Emerg Med. 1995 Sep;2(9):773-83. Unique Identifier : AIDSLINE MED/96026568; Jui J; Stevens P; Hedberg K; Modesitt S; Department of Emergency Medicine, Oregon Health Sciences; University, Portland 97201, USA.; OBJECTIVES: In Portland, OR: 1) to determine the changes in HIV seroprevalence for ED patients from 1988 to 1991, 2) to define the characteristics of the HIV-positive ED patient, 3) to determine the hepatitis B seroprevalence of HIV-seropositive ED patients, and 4) to demonstrate the feasibility of an ED population-ba
[Comparative study of the prevalence of hepatitis B virus infection and human immunodeficiency virus type 1 infection in the prison population between 1985 and 1992]: Gastroenterol Hepatol. 1995 Oct;18(8):405-9. Unique Identifier : AIDSLINE MED/96058895; del Olmo JA; Anon C; Llovet F; Serra MA; Wassel A; Rodrigo JM; Unidad de Hepathologia, Hospital Clinico Universitario, Equipo; de Salud del Centro Penitenciario de Preventivos, Picassent,; Valencia.; The prisoner population of the penitentiaries presents an elevated prevalence of hepatitis B virus (HBV) and human immunodeficiency type 1 (HIV-1) infection markers. In the last few years different measures have been developed to prevent infection. This study evaluates whether there have been changes in the prevalence
HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women.: Nat Med. 1995 Jan;1(1):59-64. Unique Identifier : AIDSLINE MED/96071373; Rowland-Jones S; Sutton J; Ariyoshi K; Dong T; Gotch F; McAdam S; Whitby D; Sabally S; Gallimore A; Corrah T; et al; Institute of Molecular Medicine, John Radcliffe Hospital,; Headington, Oxford, UK.; A crucial requirement in the rational design of a prophylactic vaccine against the human immunodeficiency virus (HIV) is to establish whether or not protective immunity can occur following natural infection. The immune response to HIV infection is characterized by very vigorous HIV-specific cytotoxic T-lymphocyte (CTL
Microsatellite instability in primary neoplasms from HIV + patients.: Nat Med. 1995 Jan;1(1):65-8. Unique Identifier : AIDSLINE MED/96071374; Bedi GC; Westra WH; Farzadegan H; Pitha PM; Sidransky D; Department of Otolaryngology--Head and Neck Surgery, Johns; Hopkins University School of Medicine, Baltimore, Maryland; 21205-2196, USA.; AIDS is associated with a high risk of certain malignancies, notably Kaposi s sarcoma (KS) and B-cell non-Hodgkin s lymphoma (NHL). The pathogenesis of these malignancies is not fully understood. One mechanism of malignant transformation recently described in colon tumorigenesis re
gp 120: good, bad or indifferent? [news]: Nat Med. 1995 Nov;1(11):1105-6. Unique Identifier : AIDSLINE MED/96071653; Steele FR
Courts favour HIV compensation [news]: Nat Med. 1995 Nov;1(11):1106. Unique Identifier : AIDSLINE MED/96071654; Nathan R
Whether and when an AIDS vaccine?: Nat Med. 1995 Nov;1(11):1126-9. Unique Identifier : AIDSLINE MED/96071659; Hilleman MR; Merck Institute for Therapeutic Research, Merck Research; Laboratories, West Point, Pennsylvania 19486, USA.
Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques.: Nat Med. 1995 Nov;1(11):1167-73. Unique Identifier : AIDSLINE MED/96071672; Gallimore A; Cranage M; Cook N; Almond N; Bootman J; Rud E; Silvera P; Dennis M; Corcoran T; Stott J; et al; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford,; UK.; In order to develop a successful subunit vaccine against infection with the human immunodeficiency virus (HIV), protective immune effector functions must be identified. Until now, there has been only indirect evidence that HIV-specific cytotoxic T lymphocytes (CTLs) fulfill this role. Using the macaque simian immunode
Decreased expression of AMPA receptor messenger RNA and protein in AIDS: a model for HIV-associated neurotoxicity.: Nat Med. 1995 Nov;1(11):1174-8. Unique Identifier : AIDSLINE MED/96071673; Everall IP; Hudson L; al-Sarraj S; Honavar M; Lantos P; Kerwin R; HIV infection can cause extensive neuronal loss and clinically a severe dementia . The cause of the neurotoxicity remains unclear as neurons are not infected, but disturbance of glutamate-linked calcium entry has been implicated. In this study, we have shown a decrease in HIV-infect
Blood substitutes--a moving target.: Nat Med. 1995 Nov;1(11):1212-5. Unique Identifier : AIDSLINE MED/96071681; Winslow RM; Department of Medicine, School of Medicine, University of; California at San Diego, USA.
Japan to open first AIDS clinic [news]: Nat Med. 1995 Feb;1(2):104-5. Unique Identifier : AIDSLINE MED/96071383; Hannay T
Apoptosis in HIV infection [comment]: Nat Med. 1995 Feb;1(2):118-20. Unique Identifier : AIDSLINE MED/96071387; Pantaleo G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.
A fight to the death.: Nat Med. 1995 Feb;1(2):122-4. Unique Identifier : AIDSLINE MED/96071389; Short N
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes [see comments]: Nat Med. 1995 Feb;1(2):129-34. Unique Identifier : AIDSLINE MED/96071391; Finkel TH; Tudor-Williams G; Banda NK; Cotton MF; Curiel T; Monks C; Baba TW; Ruprecht RM; Kupfer A; Department of Pediatrics, National Jewish Center for Immunology; and Respiratory Medicine, Denver, Colorado 80206, USA.; Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that carries the CD4 antigen. We and others have shown an increase in the percentage of apoptotic cells among circulating CD4+ (and CD8+) T
Dingell disavows 'Dingell' report on Gallo [news]: Nat Med. 1995 Mar;1(3):188. Unique Identifier : AIDSLINE MED/96071404; Culliton BJ
FDA panel reluctantly approves AIDS vaccine trial [news]: Nat Med. 1995 Mar;1(3):191-2. Unique Identifier : AIDSLINE MED/96071405; Fox JL
DNA-based testing not yet ready for routine screening of blood [news]: Nat Med. 1995 Mar;1(3):192-3. Unique Identifier : AIDSLINE MED/96071406; Fox JL
AIDS drugs lurch towards market [news]: Nat Med. 1995 Apr;1(4):285-6. Unique Identifier : AIDSLINE MED/96071431; Steele F
Assessing animal models of AIDS [comment]: Nat Med. 1995 Apr;1(4):295-7. Unique Identifier : AIDSLINE MED/96071432; Stott J; Almond N; National Institute for Biological Standards and Control, South; Mimms, Potters Bar, Hertfordshire, UK.
CTL to HIV-1: surrogates or sirens [comment]: Nat Med. 1995 Apr;1(4):304-5. Unique Identifier : AIDSLINE MED/96071437; Mathieson BJ; Division of Aids, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.
HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques [see comments]: Nat Med. 1995 Apr;1(4):321-9. Unique Identifier : AIDSLINE MED/96071441; Abimiku AG; Franchini G; Tartaglia J; Aldrich K; Myagkikh M; Markham PD; Chong P; Klein M; Kieny MP; Paoletti E; et al; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-4255,; USA.; Rhesus macaques were immunized with attenuated vaccinia or canarypox human immunodeficiency virus type 1 (HIV-1) recombinants and boosted with HIV-1 protein subunits formulated in alum. Following challenge with HIV-2SBL6669, three out of eight immunized macaques resisted infection for six months and another exhibited
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression [see comments]: Nat Med. 1995 Apr;1(4):330-6. Unique Identifier : AIDSLINE MED/96071442; Koenig S; Conley AJ; Brewah YA; Jones GM; Leath S; Boots LJ; Davey V; Pantaleo G; Demarest JF; Carter C; et al; MedImmune, Inc., Gaithersburg, Maryland 20878, USA.; An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followe
Apoptosis and HIV disease [letter; comment]: Nat Med. 1995 May;1(5):386-7. Unique Identifier : AIDSLINE MED/96071454; Lu W; Andrieu JM
Tokyo HIV-contaminated blood product hearing [news]: Nat Med. 1995 May;1(5):396. Unique Identifier : AIDSLINE MED/96071456; Hannay T
Considerable ferment over antifungal agents [news]: Nat Med. 1995 May;1(5):398. Unique Identifier : AIDSLINE MED/96071457; Fox JL
Testing anti-HIV drugs in the FIV model.: Nat Med. 1995 May;1(5):410-1. Unique Identifier : AIDSLINE MED/96071463; North TW; LaCasse RA; Division of Biological Sciences, University of Montana, Missoula; 59812, USA.
Mitochondrial toxicity of antiviral drugs.: Nat Med. 1995 May;1(5):417-22. Unique Identifier : AIDSLINE MED/96071467; Lewis W; Dalakas MC; Department of Pathology and Laboratory Medicine, University of; Cincinnati College of Medicine, Ohio 45267-0529, USA.; Long-term treatment with antiviral nucleoside analogue drugs, such as AZT , can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diver
Blood safety [letter; comment]: Nat Med. 1995 Jun;1(6):493. Unique Identifier : AIDSLINE MED/96071485; Grgicevic D
Blood safety [letter; comment]: Nat Med. 1995 Jun;1(6):493. Unique Identifier : AIDSLINE MED/96071486; Potocnik M
'Bypass' budget reveals AIDS research funding priorities [news]: Nat Med. 1995 Jun;1(6):499. Unique Identifier : AIDSLINE MED/96071487; Steele FR
Rational drug design and HIV: hopes and limitations.: Nat Med. 1995 Jun;1(6):519-20. Unique Identifier : AIDSLINE MED/96071493; Goody RS; Max-Planck-Institut fur Molekulare Physiologie, Dortmund,; Germany.
T-cell dynamics of immunodeficiency [comment]: Nat Med. 1995 Jul;1(7):621-2. Unique Identifier : AIDSLINE MED/96071514; Roederer M; Department of Genetics Stanford University School of Medicine,; California 94305, USA.
Targeting HIV reverse transcriptase in novel ways [comment]: Nat Med. 1995 Jul;1(7):628-9. Unique Identifier : AIDSLINE MED/96071518; Wainberg MA; Gu Z; McGill University AIDS Centre, Jewish General Hospital, Montreal,; Quebec, Canada.
Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro [see comments]: Nat Med. 1995 Jul;1(7):667-73. Unique Identifier : AIDSLINE MED/96071529; Maciejewski JP; Weichold FF; Young NS; Cara A; Zella D; Reitz MS Jr; Gallo RC; Hematology Branch, National Heart, Lung and Blood Institute,; National Institutes of Health, Bethesda, Maryland 20892-1652,; USA.; We have tested a novel strategy of intracellular immunization to block human immunodeficiency virus (HIV) infection. The expression of a specific antibody within a cell was achieved by transduction of genes that encode for immunoglobulin chains with specificity to viral reverse transcriptase. We demonstrated that inhi
Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study [see comments]: Nat Med. 1995 Jul;1(7):674-80. Unique Identifier : AIDSLINE MED/96071530; Margolick JB; Munoz A; Donnenberg AD; Park LP; Galai N; Giorgi JV; O'Gorman MR; Ferbas J; Department of Molecular Biology and Immunology, Johns Hopkins; University School of Hygiene and Public Health, Baltimore,; Maryland 21205-2179, USA.; We and others have postulated that a constant number of T lymphocytes is normally maintained without regard to CD4+ or CD8+ phenotype ( blind T-cell homeostasis). Here we confirm essentially constant T-cell levels (despite marked decline in CD4+ T cells and increase in CD8+ T cells) in homosexual men with incident hu
Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate.: Nat Med. 1995 Jul;1(7):681-5. Unique Identifier : AIDSLINE MED/96071531; Bukawa H; Sekigawa K; Hamajima K; Fukushima J; Yamada Y; Kiyono H; Okuda K; Department of Oral and Maxillofacial Surgery, Yokohama City; University School of Medicine, Japan.; Control of pandemic infection of human immunodeficiency virus type 1 (HIV-1) requires some means of developing mucosal immunity against HIV-1 because sexual transmission of the virus occurs mainly through the mucosal tissues. However, there is no evidence as yet that the secretory immunoglobulin A (IgA) antibody induc
A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma.: Nat Med. 1995 Jul;1(7):707-8. Unique Identifier : AIDSLINE MED/96071537; Schalling M; Ekman M; Kaaya EE; Linde A; Biberfeld P; Department of Molecular Medicine, Karolinska Institute and; Hospital, Stockholm, Sweden.; Kaposi s sarcoma (KS) is a previously rare, tumour-like lesion of controversial biological nature. KS has since the early 1980s become frequent in patients with AIDS, particularly in homosexuals. KS is also endemic in Central Africa predominantly in otherwise healthy men but also in women and children. Recently, evide
CDC and Congress at odds over mandatory HIV testing [news]: Nat Med. 1995 Aug;1(8):723-4. Unique Identifier : AIDSLINE MED/96071544; Touchette N
What direction for AIDS drug task force? [news]: Nat Med. 1995 Aug;1(8):725. Unique Identifier : AIDSLINE MED/96071545; Steele FR
Scandal touches HIV vaccine development in Japan [news]: Nat Med. 1995 Aug;1(8):727. Unique Identifier : AIDSLINE MED/96071546; Nathan R
Human retroviruses in the second decade: a personal perspective.: Nat Med. 1995 Aug;1(8):753-9. Unique Identifier : AIDSLINE MED/96071556; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892-4255,; USA.; Human retroviruses have developed novel strategies for their propagation and survival. A consequence of their success has been the induction of an extraordinarily diverse set of human diseases, including AIDS, cancers and neurological and inflammatory disorders. Early research focused on their characterization, linkag
Keeping a lid on marijuana research [news]: Nat Med. 1995 Sep;1(9):853-4. Unique Identifier : AIDSLINE MED/96071580; Steele FR
New global AIDS programme trying to break with the past [news]: Nat Med. 1995 Sep;1(9):862. Unique Identifier : AIDSLINE MED/96071581; Tastemain C
HIV and CD26 [comment]: Nat Med. 1995 Sep;1(9):881-2. Unique Identifier : AIDSLINE MED/96071588; Dalgleish A; St. George's Hospital Medical School, University of London, UK.
Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung [see comments]: Nat Med. 1995 Sep;1(9):890-3. Unique Identifier : AIDSLINE MED/96071593; Yang Y; Trinchieri G; Wilson JM; Institute for Human Gene Therapy, Wistar Institute, University of; Pennsylvania Medical Center, Philadelphia 19104-4268, USA.; Enthusiasm for the use of recombinant adenoviruses in gene therapy has been tempered by the problematic immune responses that develop to the virus and virus-infected cells. Humoral immune responses to the input viral proteins generate neutralizing antibodies that thwart attempts to effectively administer the therapy m
Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine.: Nat Med. 1995 Sep;1(9):914-8. Unique Identifier : AIDSLINE MED/96071597; Putkonen P; Walther L; Zhang YJ; Li SL; Nilsson C; Albert J; Biberfeld P; Thorstensson R; Biberfeld G; Department of Immunology, Swedish Institute for Infectious; Disease Control, Karolinska Institute, Stockholm, Sweden.; The aim of this study was to test the ability of a live attenuated human immunodeficiency virus type 2 (HIV-2) vaccine to protect cynomolgus monkeys against superinfection with a pathogenic simian immunodeficiency virus (SIVsm). This report is an update on our previously reported observation period of nine months. The
CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line [see comments]: Nat Med. 1995 Sep;1(9):919-26. Unique Identifier : AIDSLINE MED/96071598; Oravecz T; Roderiquez G; Koffi J; Wang J; Ditto M; Bou-Habib DC; Lusso P; Norcross MA; Division of Hematologic Products, Food and Drug Administration,; National Institutes of Health, Bethesda, Maryland 20892, USA.; Experiments to identify cell determinants involved in HIV-1 tropism revealed a specific decrease in the expression of the T-cell activation antigen CD26 after monocytotropic (M-tropic) but not T-cell line-tropic (T-tropic) virus infection of the PM1 T-cell line. The level of CD26 expression in single-cell clones of PM
Resistance of microorganisms to disinfection in dental and medical devices [see comments]: Nat Med. 1995 Sep;1(9):956-8. Unique Identifier : AIDSLINE MED/96071605; Lewis DL; Arens M; Department of Ecology, University of Georgia, Athens 30602, USA.; The U.S. Centers for Disease Control and Prevention (CDC) recommends that only heat sterilization be used for all reusable devices entering the oral cavity. However, chemical disinfection is still employed for reprocessing dental devices in many areas of the world. In an analysis of a Florida dental practice responsib
Analysis of the role of the pseudoknot component in the SRV-1 gag-pro ribosomal frameshift signal: loop lengths and stability of the stem regions.: RNA. 1995 Apr;1(2):146-54. Unique Identifier : AIDSLINE MED/96079947; ten Dam EB; Verlaan PW; Pleij CW; Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden; University, The Netherlands.; The simian retrovirus-1 (SRV-1) gag-pro frameshift signal was identified in previous work, and the overall structure of the pseudoknot involved was confirmed (ten Dam E, Brierley I, Inglis S, Pleij C, 1994, Nucleic Acids Res 22:2304-2310). Here we report on the importance of specific elements within the pseudoknot. So
How reliable is computerized assessment of readability?: Comput Nurs. 1995 Sep-Oct;13(5):221-5. Unique Identifier : AIDSLINE MED/96005263; Mailloux SL; Johnson ME; Fisher DG; Pettibone TJ; Kenai Care Center, Alaska, USA.; To assess the consistency and comparability of readability software programs, four software programs (Corporate Voice, Grammatix IV, Microsoft Word for Windows, and RightWriter) were compared. Standard materials included 28 pieces of printed educational materials on human immunodeficiency virus/acquired immunodeficien
Analysis of sewage effluent for human immunodeficiency virus (HIV) using infectivity assay and reverse transcriptase polymerase chain reaction.: Can J Microbiol. 1995 Sep;41(9):809-15. Unique Identifier : AIDSLINE MED/96086645; Palmer CJ; Lee MH; Bonilla GF; Javier BJ; Siwak EB; Tsai YL; Environmental Sciences Laboratory, County Sanitation Districts of; Orange County, Fountain Valley, CA 92728-8127, USA.; Environmental survival of human immunodeficiency virus type 1 (HIV-1) is an important public health concern. Survival of HIV in waste water is of particular interest to those who work at treatment facilities and to the general public who have contact with rivers or ocean water receiving treated sewage effluent. Other
Number of needlestick injuries still a concern [news]: Can Med Assoc J. 1995 Nov 15;153(10):1484. Unique Identifier : AIDSLINE MED/96067042
WHO launches school health plan [news]: Can Med Assoc J. 1995 Nov 15;153(10):1484. Unique Identifier : AIDSLINE MED/96067041
Human sperm and spermatogonia express a galactoglycerolipid which interacts with gp120.: J Submicrosc Cytol Pathol. 1995 Oct;27(4):565-71. Unique Identifier : AIDSLINE MED/96076722; Brogi A; Presentini R; Piomboni P; Collodel G; Strazza M; Solazzo D; Costantino-Ceccarini E; Institute of General Biology, University of Siena, Italy.; Sexual transmission is a major mode of spread of HIV-1 although the mechanisms involved remain to be elucidated. The role of spermatozoa as carriers of the HIV is supported by recent publications, while the expression of the CD4 on the membrane of the sperm has not yet been demonstrated. The data reported in this pape
Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine.: Cancer Res. 1995 Nov 1;55(21):4776-9. Unique Identifier : AIDSLINE MED/96046570; Pan ZK; Ikonomidis G; Pardoll D; Paterson Y; Department of Microbiology, University of Pennsylvania,; Philadelphia 19104-6076, USA.; We have shown previously that Listeria monocytogenes, a gram-positive, facultative intracellular bacterium, is a potent vector for targeting tumor-specific antigens to the immune system. After parenteral administration, we observed protection against both renal and colorectal mouse tumors and regression of established
ET-18-OCH3 inhibits nuclear factor-kappa B activation by 12-O-tetradecanoylphorbol-13-acetate but not by tumor necrosis factor-alpha or interleukin 1 alpha.: Cancer Res. 1995 Nov 1;55(21):4844-9. Unique Identifier : AIDSLINE MED/96046585; Daniel LW; Civoli F; Rogers MA; Smitherman PK; Raju PA; Roederer M; Department of Biochemistry, Bowman Gray School of Medicine, Wake; Forest University, Winston-Salem, North Carolina 27157-1016, USA.; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC). Our previous studies indicate that the selective inhibition of tumor cell growth by ET-18-OCH3 may be due to alt
B7-1 and interleukin 12 synergistically induce effective antitumor immunity.: Cancer Res. 1995 Nov 1;55(21):4980-7. Unique Identifier : AIDSLINE MED/96046606; Coughlin CM; Wysocka M; Kurzawa HL; Lee WM; Trinchieri G; Eck SL; Biomedical Graduate Program, University of Pennsylvania,; Philadelphia 19104, USA.; Enhanced host rejection of tumor cells is the primary goal of cancer immunotherapy and, in many murine tumor models, has been accomplished by engineering cells to express B7 costimulatory molecules or creating an environment rich in certain cytokines. We examined the effect of tumor cell B7-1 expression and administer
Detection of mammary tumor virus env gene-like sequences in human breast cancer.: Cancer Res. 1995 Nov 15;55(22):5173-9. Unique Identifier : AIDSLINE MED/96062161; Wang Y; Holland JF; Bleiweiss IJ; Melana S; Liu X; Pelisson I; Cantarella A; Stellrecht K; Mani S; Pogo BG; Department of Medicine, Mount Sinai School of Medicine, CUNY, New; York 10029, USA.; Mouse mammary tumor virus (MMTV) has been related to human breast cancer (BC) in previous studies. Although suggestive sequence homology to MMTV has been described in BC DNA, the presence of human endogenous retroviruses (HERs) confounded these results. We have selected a 660-bp sequence of the MMTV env gene with very
Methylcholanthrene-induced mouse sarcomas express individually distinct major histocompatibility complex class I-associated peptides recognized by specific CD8+ T-cell lines.: Cancer Res. 1995 Dec 1;55(23):5648-55. Unique Identifier : AIDSLINE MED/96075549; Kono K; Petersson M; Ciupitu AM; Wen T; Klein G; Kiessling R; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.; Mouse sarcomas induced by methylcholanthrene (MC) are immunologically distinct even if they are induced in the same strain of mice. T-cell lines were derived from mice immunized against a series of syngeneic MC sarcomas on B6 background, known to carry unique tumor-specific transplantation antigens. Tumor necrosis fac
One new role for nurses.: Colo Nurse. 1995 Sep;95(3):9-10. Unique Identifier : AIDSLINE MED/96037709; Hinds C
Ganciclovir absolute bioavailability and steady-state pharmacokinetics after oral administration of two 3000-mg/d dosing regimens in human immunodeficiency virus- and cytomegalovirus-seropositive patients.: Clin Ther. 1995 May-Jun;17(3):425-32. Unique Identifier : AIDSLINE MED/96070351; Anderson RD; Griffy KG; Jung D; Dorr A; Hulse JD; Smith RB; Novum, Inc., Pittsburgh, Pennsylvania, USA.; Oral ganciclovir has recently been approved for use in long-term maintenance therapy in the treatment of cytomegalovirus ( CMV ) retinitis in immunocompromised patients. Although oral ganciclovir at a dose of 3,000 mg/d is mode
Intracellular calcium release induced by human immunodeficiency virus type 1 (HIV-1) surface envelope glycoprotein in human intestinal epithelial cells: a putative mechanism for HIV-1 enteropathy.: Cell Calcium. 1995 Jul;18(1):9-18. Unique Identifier : AIDSLINE MED/96000449; Dayanithi G; Yahi N; Baghdiguian S; Fantini J; Laboratoire de Neurobiologie Endocrinologique, CNRS URA 1197,; Universite Montpellier 2, France.; Intracellular Ca2+ ([Ca2+]i) was measured in single human epithelial intestinal HT-29-D4 cells with the Ca2+ probe Fura-2 and digital imaging microscopy. Treatment of these cells with HIV-1 surface envelope glycoprotein gp120 (or a soluble form of its precursor gp160) induced an important increase of [Ca2+]i. This eff
AIDS, Ebola and other new epidemics: theme of European Conference on Tropical Medicine in Hamburg [news]: Cent Afr J Med. 1995 Aug;41(8):264. Unique Identifier : AIDSLINE MED/96031197; Papendorf J
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.: Cell. 1995 Nov 17;83(4):569-76. Unique Identifier : AIDSLINE MED/96069858; Gallay P; Swingler S; Song J; Bushman F; Trono D; Infectious Disease Laboratory, Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine
A subset of splenic macrophages process and present native antigen to naive antigen-specific CD4+ T-cells from mice transgenic for an alpha beta T-cell receptor.: Cell Immunol. 1995 Nov;166(1):62-70. Unique Identifier : AIDSLINE MED/96067656; Askew D; Gatewood J; Olivas E; Havenith K; Walker WS; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee 38105, USA.; The progeny of individual macrophage precursors from mouse spleen were examined for their ability to constitutively process and present native pigeon cytochrome c or a peptide fragment of this antigen to naive CD4+ T-cells from mice transgenic for a V alpha 11/V beta 3 TCR that recognizes an epitope in the antigen fra
High-density presentation of an immunodominant minimal peptide on B cells is MHC-linked to Th1-like immunity.: Cell Immunol. 1995 Nov;166(1):9-15. Unique Identifier : AIDSLINE MED/96067650; Murray JS; Kasselman JP; Schountz T; Division of Biology, Kansas State University, Manhattan 66506,; USA.; Ligand-directed differences in the amount of peptide presented on a specific APC subset could influence the functional outcome of any given immune response. We have investigated this issue with a biochemically determined immunodominant peptide that is presented at a higher density on the APC of Th1 responders (I-As ge
The inhibitory effect of the crude extract from a seaweed of Dygenea simplex C. Agardh on the in vitro cytopathic activity of HIV-1 and it's antigen production.: Chem Pharm Bull (Tokyo). 1995 Sep;43(9):1580-4. Unique Identifier : AIDSLINE MED/96003369; Sekine H; Ohonuki N; Sadamasu K; Monma K; Kudoh Y; Nakamura H; Okada Y; Okuyama T; Department of Microbiology, Tokyo Metropolitan Research; Laboratory of Public Health, Japan.; The crude water extract (NS-1) from a seaweed (Digenea simplex C. Agardh Rhodomelaceae) exhibited anti-human immunodeficiency virus (HIV)-1 activity in vitro. The inhibitory effect of the extract on the cytopathic activity of HIV-1 and it s antigen production was examined using a microplate method, immunofluorescent a
Pericardial effusion in AIDS. Incidence and survival.: Circulation. 1995 Dec 1;92(11):3229-34. Unique Identifier : AIDSLINE MED/96080076; Heidenreich PA; Eisenberg MJ; Kee LL; Somelofski CA; Hollander H; Schiller NB; Cheitlin MD; Division of Cardiology, University of California, San Francisco,; USA.; BACKGROUND: Although pericardial effusion is known to be common among patients infected with HIV, the incidence of pericardial effusion and its relation to survival have never been described. METHODS AND RESULTS: To evaluate the incidence of pericardial effusion and its relation to mortality in HIV-positive subjects,
Components of biological variation in plasma haptoglobin: relationships to plasma fibrinogen and immune variables, including interleukin-6 and its receptor.: Clin Chim Acta. 1995 Jul 31;239(1):23-35. Unique Identifier : AIDSLINE MED/96051324; Maes M; Cooreman W; Delanghe J; Scharpe S; Wauters A; Neels H; D'Hondt P; Peeters D; Cosyns P; Ranjan R; et al; Department of Psychiatry, University Hospitals of Cleveland,; Ohio, USA.; We investigated the components of biological variation, including seasonality, in plasma haptoglobin (Hp) levels and the relationships between plasma Hp and interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6), sIL-2R, fibrinogen (Fb) and absolute number of peripheral blood mononuclear cells, such as leukocytes, neutro
Mercury: god of Th2 cells? [editorial; comment]: Clin Exp Immunol. 1995 Nov;102(2):229-30. Unique Identifier : AIDSLINE MED/96069867; Mathieson PW
Accumulation of activated CD4+ lymphocytes in the lung of individuals infected with HIV accompanied by increased virus production in patients with secondary infections.: Clin Exp Immunol. 1995 Nov;102(2):231-7. Unique Identifier : AIDSLINE MED/96069868; Franchini M; Walker C; Henrard DR; Suter-Gut D; Braun P; Villiger B; Suter M; Swiss Institute of Allergy and Asthma Research (SIAF), Davos; Platz, Switzerland.; The lung is continuously exposed to infectious and non-infectious agents causing cell activation. Activated cells in the lung such as antigen-presenting cells which harbour HIV may favour this organ as a site for virus production. To test this hypothesis, cells from blood and bronchoalveolar lavage (BAL) of HIV-infect
Effect of HIV vertical transmission on the ontogeny of T cell antigens involved in the regulation of humoral immune response.: Clin Exp Immunol. 1995 Nov;102(2):238-42. Unique Identifier : AIDSLINE MED/96069869; Brugnoni D; Soresina A; Airo P; Ugazio AG; Notarangelo LD; Cattaneo R; Duse M; Clinical Immunology Service, Spedali Civili, Brescia, Italy.; HIV infection causes progressive impairment of humoral immunity, including defective specific antibody production. To evaluate whether vertical HIV infection interferes with the expression on CD4+ lymphocytes of developmentally regulated molecules, that play a crucial role in the generation of immunological memory (CD
In vitro stimulation of peripheral blood mononuclear cells (PBMC) from HIV- and HIV+ chancroid patients by Haemophilus ducreyi antigens.: Clin Exp Immunol. 1995 Nov;102(2):243-50. Unique Identifier : AIDSLINE MED/96069870; Van Laer L; Vingerhoets J; Vanham G; Kestens L; Bwayo J; Otido J; Piot P; Roggen E; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; The cellular immune responses to fractionated Haemophilus ducreyi antigens, coated on latex beads, were assessed in patients with chancroid and in controls, using an in vitro lymphocyte proliferation assay. Several fractions of H. ducreyi antigen revealed stimulating activity. However, only the molecular size ranges 9
Gamma delta T cells in rhesus monkeys and their response to simian immunodeficiency virus (SIV) infection.: Clin Exp Immunol. 1995 Nov;102(2):251-5. Unique Identifier : AIDSLINE MED/96069871; Gan YH; Pauza CD; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706, USA.; Recent reports of the increase in peripheral blood gamma delta T cells in HIV+ patients prompted us to examine the gamma delta T cell system in rhesus monkeys (Macaca mulatta) and the responses of these cells to SIV infection. Our results reveal differences in the gamma delta T cell subset composition and their expres
Spontaneous proliferation of memory (CD45RO+) and naive (CD45RO-) subsets of CD4 cells and CD8 cells in human T lymphotropic virus (HTLV) infection: distinctive patterns for HTLV-I versus HTLV-II.: Clin Exp Immunol. 1995 Nov;102(2):256-61. Unique Identifier : AIDSLINE MED/96069872; Prince HE; York J; Owen SM; Lal RB; American Red Cross Blood Services, Southern California Region,; Los Angeles.; Spontaneous lymphocyte proliferation (SLP) in vitro is a characteristic feature of about 50% of individuals infected with HTLV-I or HTLV-II. Both CD4 cells and CD8 cells contribute to SLP in HTLV-I infection, whereas SLP in HTLV-II infection is usually restricted to CD8 cells. In this study, we asked if SLP was restri
The restricted IgG1 antibody response to maedi visna virus is seen following infection but not following immunization with recombinant gag protein.: Clin Exp Immunol. 1995 Nov;102(2):274-80. Unique Identifier : AIDSLINE MED/96069875; Bird P; Reyburn HT; Blacklaws BA; Allen D; Nettleton P; Yirrell DL; Watt N; Sargan D; McConnell I; Department of Veterinary Pathology, University of Edinburgh, UK.; Maedi-visna (MVV) is a retrovirus of the subfamily lentivirinae which includes HIV, simian immunodeficiency virus (SIV) and feline immunodeficiency virus (FIV). Infection of its natural host, the sheep, does not cause overt immunodeficiency, but rather a chronic inflammatory disease. However, subtle immunological chan
CD4+/CD8+ ratio of liver-derived lymphocytes is related to viraemia and not to hepatitis C virus genotypes in chronic hepatitis C.: Clin Exp Immunol. 1995 Nov;102(2):320-7. Unique Identifier : AIDSLINE MED/96069882; Pham BN; Martinot-Peignoux M; Mosnier JF; Njapoum C; Marcellin P; Bougy F; Degott C; Erlinger S; Cohen JH; Degos F; Service d'Hematologie et Immunologie, Hopital Beaujon, Clichy,; France.; The pathogenic mechanisms that lead to chronic hepatitis C are unknown. As hepatitis C virus (HCV) has been shown to induce T cell response, we assessed whether a particular T lymphocyte subset could be preferentially detected in the liver of patients with chronic hepatitis C in relation to viraemia or HCV genotypes.
Insulin-like growth factor-1 (IGF-1) protects NOD mice from insulitis and diabetes.: Clin Exp Immunol. 1995 Nov;102(2):335-40. Unique Identifier : AIDSLINE MED/96069884; Bergerot I; Fabien N; Maguer V; Thivolet C; INSERM U. 197, Faculte de Medecine, Alexis Carrel, Lyon,; France.; To evaluate the effect of IGF-1 on the autoimmune process of beta cell destruction, permissive non-obese diabetic (NOD) recipients were adoptively transferred with 7 x 10(6) autoreactive T cells from diabetic NOD mice and were administered subcutaneously 10 micrograms rhIGF-1, twice daily for 3 weeks. Administration o
Investigation of the complement receptor 3 (CD11b/CD18) in human rectal epithelium.: Clin Exp Immunol. 1995 Nov;102(2):384-8. Unique Identifier : AIDSLINE MED/96069892; Hussain LA; Kelly CG; Rodin A; Jourdan M; Lehner T; Department of Immunology, United Medical School, Guy's Hospital,; London, UK.; Rectal and cervicovaginal mucosa are common routes of transmission of HIV, although the mechanism of transmission is unknown. We have investigated human rectal and cervicovaginal epithelia for the expression of complement receptors (CR) and cell adhesion molecules which may be involved in HIV and other infections. In
Production of inflammatory cytokines by Epstein-Barr virus (EBV)-infected lymphoblastoid cell lines spontaneously originated from the peripheral blood of patients with human immunodeficiency virus (HIV) infection.: Clin Immunol Immunopathol. 1995 Nov;77(2):162-71. Unique Identifier : AIDSLINE MED/96036726; Roncella S; Baldi L; Cutrona G; Viale M; Rizzo F; Gasco M; Ferrarini M; Pistoia V; Services of Clinical Immunology, National Institute for Cancer; Research, Genoa, Italy.; In this study we have raised spontaneous Epstein-Barr virus (EBV)-positive lymphoblastoid cell lines (LCL) from the peripheral blood of human immunodeficiency virus (HIV)-infected individuals and of control patients with primary EBV infections. These LCLs were also raised in the presence of the viral inhibitor phospho
Direct inhibition of human CD8+ lymphocyte activation by cyclosporine A and Rapamune-Sirolimus.: Clin Immunol Immunopathol. 1995 Dec;77(3):221-8. Unique Identifier : AIDSLINE MED/96080349; Combates NJ; Degiannis D; Raskova J; Raska K Jr; Johnson and Johnson CPWW, Skillman, New Jersey 08558, USA.; Cyclosporin A (CsA) and Rapamune-Sirolimus (RAP) have been shown to inhibit the in vitro activation of heterogeneous lymphocytes populations, but little is known about their direct actions on isolated CD8+ lymphocytes. In this study the direct effects of RAP and CsA on a highly purified population of CD8+ lymphocytes
A CD3+CD8+ T cell population lacking CD5 antigen expression is expanded in peripheral blood of human immunodeficiency virus-infected patients.: Clin Immunol Immunopathol. 1995 Dec;77(3):253-61. Unique Identifier : AIDSLINE MED/96080353; Indraccolo S; Mion M; Zamarchi R; Coppola V; Calderazzo F; Amadori A; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.; In this study we analyzed the behavior of a CD3+ T cell subpopulation lacking CD5 antigen expression in PBMC from HIV-1-infected patients. CD3+CD5- lymphocytes were greatly increased in peripheral blood of HIV-1+ patients, accounting for 20.6 +/- 9.9% of the total CD3+ cells, compared to seronegative individuals (5.5
Human immunodeficiency virus type 1 infection of CD4+ T cells down-regulates the expression of CD28: effect on T cell activation and cytokine production.: Clin Immunol Immunopathol. 1995 Dec;77(3):262-70. Unique Identifier : AIDSLINE MED/96080354; Haffar OK; Smithgall MD; Wong JG; Bradshaw J; Linsley PS; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; Infection with human immunodeficiency virus type 1 (HIV-1) results in dysregulation of normal T cell function. To study the effects of HIV-1 at the cellular level, primary T cell lines were generated by alloantigen stimulation of CD4+ T cells collected from peripheral blood of HIV-1-infected donors. Using Epstein-Barr
IgG autoantibody response in HTLV-I-infected patients.: Clin Immunol Immunopathol. 1995 Dec;77(3):282-90. Unique Identifier : AIDSLINE MED/96080356; Muller S; Boire G; Ossondo M; Ricchiuti V; Smadja D; Vernant JC; Ozden S; Institut de Biologie Moleculaire et Cellulaire, UPR 9021 Centre; National de la Recherche Scientifique, Strasbourg, France.; Human T-cell leukemia virus type I (HTLV-I) is associated with a large spectrum of clinical manifestation including adult T-cell leukemia (ATL) and tropical spastic paraparesis or HTLV-I-associated myelopathy (TSP/HAM). In most cases, however, infected patients remain asymptomatic. The participation of the immune syst
Cutaneous immunopathology of cyclosporin-A-induced autoimmunity in the rat.: Clin Immunol Immunopathol. 1995 Dec;77(3):315-23. Unique Identifier : AIDSLINE MED/96080360; Damoiseaux JG; Beijleveld LJ; van Breda Vriesman PJ; Department of Immunology, University of Limburg, Maastricht, The; Netherlands.; Syngeneic bone marrow transplantation following lethal X-irradiation and subsequent administration of cyclosporin A (CsA) results after cessation of CsA treatment in an autoimmune disease which is thymus dependent and resembles graft-versus-host disease. The chronic dermal changes of this experimental autoimmune model
Differential effect of TGF-beta 1 on the in vitro activation of HTLV-I and the proliferative response of CD8+ T lymphocytes in patients with HTLV-I-associated myelopathy (HAM/TSP).: Clin Immunol Immunopathol. 1995 Dec;77(3):324-31. Unique Identifier : AIDSLINE MED/96080361; Nagai M; Ijichi S; Hall WW; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.; While considerable information is available on the pathogenesis of human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), fundamental questions remain unanswered. In particular the clinicopathological uniformity of the disorder among patients remains poorly understood.
A macromolecular multicomponent peptide vaccine prepared using the glutaraldehyde conjugation method with strong immunogenicity for HIV-1.: Clin Immunol Immunopathol. 1995 Dec;77(3):374-9. Unique Identifier : AIDSLINE MED/96080367; Hamajima K; Bukawa H; Fukushima J; Kawamoto S; Kaneko T; Sekigawa K; Tanaka S; Tsukuda M; Okuda K; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.; The immunogenicity of a newly constructed macromolecular multicomponent peptide vaccine candidate against human immunodeficiency virus type 1 (HIV-1) was compared with that of previously reported vaccine candidates. This vaccine candidate is composed of a macromolecular multicomponent peptide complex consisting of thr
Pharmacokinetic optimisation of antiretroviral therapy in patients with HIV infection.: Clin Pharmacokinet. 1995 Jul;29(1):46-65. Unique Identifier : AIDSLINE MED/96065832; Stretcher BN; Department of Pathology and Laboratory Medicine, University of; Cincinnati College of Medicine, Ohio, USA.; More than 7 years after the introduction of zidovudine for treatment of HIV infection, little use has been made of the pharmacokinetic properties of this or any of the subsequently approved antiretroviral agents to optimise therapy. This is partly because of the limits of technologies developed to measure clinically r
Antibodies to human immunodeficiency virus (HIV-1) in autoimmune diseases: primary Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis and autoimmune thyroid diseases.: Clin Rheumatol. 1995 Jul;14(4):451-7. Unique Identifier : AIDSLINE MED/96070334; Coll J; Palazon J; Yazbeck H; Gutierrez J; Aubo C; Benito P; Jagiello P; Maldyk H; Marrugat J; Anglada J; et al; Department of Medicine, Hospital del Mar, Universidad Autonoma; de Barcelona, Spain.; The aetiology of autoimmune diseases remains unknown. The relationship between virus, and more recently retrovirus, has been suggested with this group of diseases. Immunoblotting is a useful method for determining the presence of proteins coded by different retrovirus genes. Since the prevalence of these types of prot
[Update on the use of interferons in clinical practice]: Clin Ter. 1995 Jun-Jul;146(6-7):393-448. Unique Identifier : AIDSLINE MED/96079574; Lauta VM; Dipartimento di Scienze Biomediche ed Oncologia Umana,; Universita degli Studi di Bari.; Discovered by Isaac and Lindemann as a substance able to induce a biological interference among viruses and host cells, interferon appeared to include three main antigenic classes: alpha, beta and gamma. There is a large variety of actions exhibited by different types of interferon and among them it is possible to dis
Dental care of infectious patients in Denmark, 1986-1993: theoretical considerations and empirical findings.: Community Dent Oral Epidemiol. 1995 Aug;23(4):226-31. Unique Identifier : AIDSLINE MED/96037073; Scheutz F; Langebaek J; Department of Oral Epidemiology and Public Health, Royal Dental; College, Faculty of Health Sciences, Aarhus University, Denmark.; Changes in infection control and behavior and attitudes towards HIV-infected patients from 1986 to 1992/93 were studied among a random sample of 335 Danish dentists; previous studies among random samples of Danish dentists served as references. 249 (74.3%) returned a mailed questionnaire together with a time, steam, t
Sexually transmitted disease prevention services for female chronically mentally ill patients.: Community Ment Health J. 1995 Aug;31(4):303-15. Unique Identifier : AIDSLINE MED/96075990; Coverdale JH; Bayer TL; McCullough LB; Chervenak FA; Department of Psychiatry, Baylor College of Medicine, Houston,; Texas, USA.; Chronically and variably impaired autonomy makes women with chronic mental illness particularly vulnerable to contracting sexually transmitted diseases (STDs) including AIDS. A lack of female controlled protective devices also adds to the vulnerability of these patients. In this context, the authors make recommendatio
David Byar: an accidental career. Scientific workshop, November 7-8, 1991, Bethesda, Maryland. Proceedings.: Control Clin Trials. 1995 Aug;16(4):187-275. Unique Identifier : AIDSLINE MED/96000475
In memoriam: David Byar as an AIDS activist.: Control Clin Trials. 1995 Aug;16(4):270-5. Unique Identifier : AIDSLINE MED/96000486; Harrington M; Treatment Action Group (TAG), New York, New York 10009, USA.
T-lymphocyte subsets in acute illness.: Crit Care Med. 1995 Oct;23(10):1680-5. Unique Identifier : AIDSLINE MED/96019887; Feeney C; Bryzman S; Kong L; Brazil H; Deutsch R; Fritz LC; Department of Internal Medicine, Highland General Hospital,; Oakland, CA 94602-1018, USA.; OBJECTIVES: To determine the range of T-lymphocyte subsets (CD4, CD8, and CD4/CD8 ratios) in acutely ill, hospitalized patients and to determine whether these concentrations correlate with illness severity, survival rate, or immunodepression. DESIGN: Cross-sectional study, comparing Acute Physiology and Chronic Health
Scabies: what's new?: Curr Probl Dermatol. 1995;22:105-11. Unique Identifier : AIDSLINE MED/96080693; Orkin M; Department of Dermatology, University of Minnesota, Minneapolis,; USA.
Follicular dendritic cells initiate and maintain infection of the germinal centers by human immunodeficiency virus.: Curr Top Microbiol Immunol. 1995;201:141-59. Unique Identifier : AIDSLINE MED/96004221; Tenner-Racz K; Racz P; Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany.
Follicular dendritic cells and infection by human immunodeficiency virus type 1--a crucial target cell and virus reservoir.: Curr Top Microbiol Immunol. 1995;201:161-88. Unique Identifier : AIDSLINE MED/96004222; Schuurman HJ; Joling P; van Wichen DF; Rademakers LH; Broekhuizen R; de Weger RA; van den Tweel JG; Goudsmit J; Sandoz Pharma Ltd., Basel, Switzerland.
HIV and dementia. Proceedings of the NIMH-sponsored conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior. April 4-7, 1994, Chantilly, Virginia.: Curr Top Microbiol Immunol. 1995;202:1-273. Unique Identifier : AIDSLINE MED/96090527
Role for astrocytosis in HIV-1-associated dementia.: Curr Top Microbiol Immunol. 1995;202:105-16. Unique Identifier : AIDSLINE MED/96004231; Vitkovic L; da Cunha A; Division of Neuroscience and Behavioral Science, National; Institute of Mental Health, National Institutes of Health,; Rockville, MD 20857, USA.
Neurocognitive disorders in HIV-1 infection. HNRC Group. HIV Neurobehavioral Research Center.: Curr Top Microbiol Immunol. 1995;202:11-32. Unique Identifier : AIDSLINE MED/96004225; Grant I; Heaton RK; Atkinson JH; Department of Psychiatry, University of California, San Diego, La; Jolla 92093-0680, USA.
Therapeutic approaches to HIV infection based on virus structure and the host pathogen interaction.: Curr Top Microbiol Immunol. 1995;202:117-32. Unique Identifier : AIDSLINE MED/96004232; Pauza CD; Streblow DN; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison 53706, USA.; The HIV-1 infection of central nervous system, with attendant neuropathy and dementia , poses a unique challenge for antiviral therapy. For practical considerations, it is important to define carefully the precise therapeutic objectives. (1) Is it necessary to inhibit spreading HIV-
Neurobiology of simian and feline immunodeficiency virus infections.: Curr Top Microbiol Immunol. 1995;202:135-50. Unique Identifier : AIDSLINE MED/96004233; Gardner MB; Dandekar S; Department of Pathology, School of Medicine, University of; California, Davis, USA.
Selected models of HIV-induced neurological disease.: Curr Top Microbiol Immunol. 1995;202:151-66. Unique Identifier : AIDSLINE MED/96004234; Narayan O; Joag SV; Stephens EB; Department of Microbiology, Marion Merrell Dow Laboratory of; Viral Pathogenesis, University of Kansas Medical Center, Kansas; City 66160-7424, USA.
Feline immunodeficiency virus as a model for study of lentivirus infection of the central nervous system.: Curr Top Microbiol Immunol. 1995;202:167-86. Unique Identifier : AIDSLINE MED/96004235; Henriksen SJ; Prospero-Garcia O; Phillips TR; Fox HS; Bloom FE; Elder JH; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, C 92037, USA.; Feline immunodeficiency virus infects the CNS and results in predictable pathophysiology strikingly similar to that seen with HIV-1 infection of humans. The observed pathophysiology is mimicked in several physiologically assessed modalities, further supporting the validity of the feline model. Peripheral and control e
Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines.: Curr Top Microbiol Immunol. 1995;202:187-205. Unique Identifier : AIDSLINE MED/96004236; Mucke L; Masliah E; Campbell IL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, CA 92037, USA.
Virus entry and release in polarized epithelial cells.: Curr Top Microbiol Immunol. 1995;202:209-19. Unique Identifier : AIDSLINE MED/96004237; Compans RW; Emory University School of Medicine, Department of Microbiology; and Immunology, Atlanta, GA 30322, USA.
Traffic of hematogenous cells through the central nervous system.: Curr Top Microbiol Immunol. 1995;202:221-45. Unique Identifier : AIDSLINE MED/96004238; Williams KC; Hickey WF; Department of Pathology, Dartmouth Medical School, Dartmouth; Hitchcock Medical Center, Lebanon, NH 03756, USA.
The pathogenesis of HIV infections of the brain.: Curr Top Microbiol Immunol. 1995;202:3-10. Unique Identifier : AIDSLINE MED/96004224; Johnson RT; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21287-7613, USA.
AIDS dementia complex and HIV-1 brain infection: a pathogenetic framework for treatment and evaluation.: Curr Top Microbiol Immunol. 1995;202:33-54. Unique Identifier : AIDSLINE MED/96004226; Price RW; Department of Neurology, University of Minnesota Health Science; Center, Minneapolis 55455-0323, USA.
Quantitative neuropathologic assessment of HIV-1 encephalitis.: Curr Top Microbiol Immunol. 1995;202:55-61. Unique Identifier : AIDSLINE MED/96004227; Wiley CA; Presbyterian University Hospital, Neuropathology Division,; Pittsburgh, PA 15213-2582, USA.
Penetration of solutes, viruses, and cells across the blood-brain barrier.: Curr Top Microbiol Immunol. 1995;202:63-78. Unique Identifier : AIDSLINE MED/96004228; Brightman MW; Ishihara S; Chang L; Laboratory of Neurobiology, National Institutes of Health,; Bethesda, MD 20892, USA.; The aspects presented here of how solutes, viruses and cells are able to cross the BBB indicate that there must be an active interaction of endothelium with viruses and immune system cells before they can penetrate the brain and spinal cord. The axoplasmic pathway taken by lectin-solute conjugates is similar but not i
Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.: Curr Top Microbiol Immunol. 1995;202:79-88. Unique Identifier : AIDSLINE MED/96004229; Kalams SA; Walker BD; Infectious Disease Unit, Harvard Medical School, Boston, MA, USA.; In summary, one can conclude that infected persons exhibit an extremely vigorous, virus-specific CTL response, and in at least some individuals this response is broadly directed at multiple epitopes. These cells are present at the time or initial control of viremia and can also be detected after more than a decade of
Distinct HIV-1 env sequences are associated with neurotropism and neurovirulence.: Curr Top Microbiol Immunol. 1995;202:89-104. Unique Identifier : AIDSLINE MED/96004230; Power C; McArthur JC; Johnson RT; Griffin DE; Glass JD; Dewey R; Chesebro B; Department of Neurology, Johns Hopkins University, Baltimore, MD; 21287, USA.
Acute lung disease in the immunocompromised host. Diagnostic accuracy of the chest radiograph.: Chest. 1995 Nov;108(5):1283-7. Unique Identifier : AIDSLINE MED/96064611; Logan PM; Primack SL; Staples C; Miller RR; Muller NL; Department of Radiology, University of British Columbia,; Vancouver, Canada.; PURPOSE: To assess the diagnostic accuracy of the chest radiograph in the evaluation of acute pulmonary complications in immunocompromised patients. METHODS: The study included the chest radiographs in 149 consecutive acute pulmonary complications seen in immunocompromised patients in whom a definitive diagnosis was m
A report on 8 seronegative converted HIV/AIDS patients with traditional Chinese medicine.: Chin Med J (Engl). 1995 Aug;108(8):634-7. Unique Identifier : AIDSLINE MED/96041449; Lu W; Wen R; Guan C; Wang Y; Shao J; Mshiu E; Mbena E; Academy of Traditional Chinese Medicine of China, Beijing.
[A survey on HIV and HV infection of heroin addicts in Linchang and Kunming]: Chung Hua Yu Fang I Hsueh Tsa Chih. 1995 Jul;29(4):228-30. Unique Identifier : AIDSLINE MED/96041548; Tang B; Tong L; Yan Q; First Affiliated Hospital, Kunming Medical College.; Serum samples were collected from 353 heroin addicts in Linchang Prefecture and Kunming Area, Yunnan Province for detecting anti-HIV with ELISA and Western Blot, and 319 of them also for detecting various infection markers of hepatitis A, B, C and D with ELISA. Results showed no anti-HIV was found among them, overall
[Use of parenteral nutritional support in patients with gastric cancer: the relationship of protein turn over, immunocompetence and tumor cell kinetics]: Chung Hua Wai Ko Tsa Chih. 1995 May;33(5):265-8. Unique Identifier : AIDSLINE MED/96041504; Cao W; Lin Y; Yin H; Ruijin Hospital, Shanghai Second Medical University.; In order to elucidate the effect of preoperative parenteral nutritional support (PNS) on protein metabolism, host immunocompetence and tumor cell kinetics, two prospective trials were made in patients with gastric cancer. All the patients were given PNS for 7 days in addition to oral intake. The positive nitrogen bala
Evaluation of T-lymphocyte subsets present in semen and peripheral blood of healthy donors: a report from the heterosexual transmission study.: Cytometry. 1995 Aug 1;20(4):349-55. Unique Identifier : AIDSLINE MED/96101991; Denny TN; Scolpino A; Garcia A; Polyak A; Weiss SN; Skurnick JH; Passannante MR; Colon J; Departments of Pediatrics and Pathology, New Jersey Medical; School, Newark, USA.; The purpose of this study was to accurately determine the T-lymphocyte subsets found in semen from healthy volunteers, to evaluate the impact of repeated ejaculation on the frequency or type of immune cells present in semen, and to compare subset analysis in semen to that in the peripheral blood. To accomplish this, a
Alterations of T-cell receptor variable region expression in human immunodeficiency virus disease.: Cytometry. 1995 Mar 15;22(1):1-9. Unique Identifier : AIDSLINE MED/96090275; McCoy JP Jr; Overton WR; Blumstein L; Baxter JD; Gekowski KM; Donaldson MH; Department of Pediatrics, Cooper Hospital/University Medical; Center, Camden, New Jersey, USA.; Since only a small percentage of CD4+ lymphocytes is infected at any one time during the course of human immunodeficiency virus (HIV) disease, a question central to the pathogenesis of HIV is whether or not the depletion of CD4+ lymphocytes is a random or selective event. The majority of peripheral blood T lymphocytes
Evidence of a selective depletion of a CD16+ CD56+ CD8+ natural killer cell subset during HIV infection.: Cytometry. 1995 Mar 15;22(1):10-5. Unique Identifier : AIDSLINE MED/96090276; Lucia B; Jennings C; Cauda R; Ortona L; Landay AL; Instituto di Clinica delle Malattie Infettive Universita; Cattolica S. Cuore Largo A. Gemelli, Roma, Italy.; Three-color flow cytometric analysis of CD16+ natural killer (NK) cells was assessed in HIV seropositive patients and healthy heterosexual controls. A selective depletion of lymphocytes with the CD16+ NK phenotype was found among the HIV+ infected patients. When the CD16 lymphocyte subset was further evaluated by thre
Variability in absolute lymphocyte counts obtained by automated cell counters.: Cytometry. 1995 Mar 15;22(1):26-34. Unique Identifier : AIDSLINE MED/96090279; Simson E; Groner W; Department of Pathology, Long Island Jewish Medical Center, New; Hyde Park, NY 11040, USA.; There is increasing interest in the absolute lymphocyte count. This is partly driven by the need to obtain absolute values for lymphocyte subsets such as absolute CD4+ counts in human immunodeficiency virus (HIV)-infected persons. The absolute total lymphocyte count is usually determined in the routine hematology labo
Idiopathic CD4+ T-lymphocytopenia: analysis of a patient with selective IgA deficiency and no evidence of HIV infection.: Cytometry. 1995 Mar 15;22(1):40-4. Unique Identifier : AIDSLINE MED/96090281; Vertes D; Linden MD; Carey JL; Department of Pathology, Henry Ford Hospital, Detroit, Michigan; 48202, USA.; Idiopathic CD4+ T-lymphocytopenia (ICL) in HIV-seronegative patients is a newly described, rare entity. The common underlying abnormality is a usually stable depletion in CD4+ lymphocytes in patients, some of which have unexplained opportunistic infections. We present a previously unreported condition of an asymptomat
Assessment of aerosol containment on the ELITE flow cytometer.: Cytometry. 1995 Mar 15;22(1):45-7. Unique Identifier : AIDSLINE MED/96090282; Ferbas J; Chadwick KR; Logar A; Patterson AE; Gilpin RW; Margolick JB; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pennsylvania,; USA.; Biohazardous aerosols generated during cell sorting have been of increased concern recently because of interest in sorting specimens containing human immunodeficiency virus type 1 (HIV-1). Current flow cytometers have features designed to contain such aerosols within the sorting chamber, but the efficacy of these feat
CD4 Lymphocyte enumeration: comparison between flow cytometry and enzyme immunoassay.: Cytometry. 1995 Mar 15;22(1):70-4. Unique Identifier : AIDSLINE MED/96090286; Cordiali Fei P; Solmone M; Vanacore P; Giglio A; Bonifati C; Carducci M; Mussi A; Chiarotti F; Ameglio F; Laboratory of Clinical Pathology, Istituto San Gallicano, Rome,; Italy.; Assessment of the CD4 lymphocyte number, currently performed by flow cytometry, is one of the main laboratory tests for establishing progression to acquired immunodeficiency syndrome (AIDS). An enzyme immunoassay has recently been commercialized which can be very useful for counting CD4 cells in laboratories where flo
Expression of the Fas antigen in patients infected with human immunodeficiency virus.: Cytometry. 1995 Jun 15;22(2):111-4. Unique Identifier : AIDSLINE MED/96090293; McCloskey TW; Oyaizu N; Kaplan M; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030, USA.; Lymphocytes from patients with HIV infection have been shown to undergo accelerated apoptosis. Fas antigen is a cell surface protein known to initiate an apoptotic signal. Therefore, we undertook a study to examine the expression of the Fas antigen during HIV infection. Using three color flow cytometry, expression of
Lymphocyte subset determination using a hematology analyzer.: Cytometry. 1995 Jun 15;22(2):150-3. Unique Identifier : AIDSLINE MED/96090299; Hudson JC; Brunhouse RF; Garrison C; Rodriguez CM; Zwerner R; Russell TR; Coulter Corporation, Miami, FL 33116-9015, USA.; Anti-CD4 antibody (T4)-coated microspheres were used to label CD4 cells in whole blood. The mixture was lysed and analyzed by a modified Coulter VCS hematology analyzer, which differentiated microsphere-labeled cells by a change in Coulter volume, conductance, and light scatter. %CD3+/CD4+ fluorescent values from a pr
Anorectal surgery in human immunodeficiency virus-infected patients. Clinical outcome in relation to immune status.: Dis Colon Rectum. 1995 Nov;38(11):1169-75. Unique Identifier : AIDSLINE MED/96060869; Consten EC; Slors FJ; Noten HJ; Oosting H; Danner SA; van Lanschot JJ; Department of Surgery, Academic Medical Centre, Amsterdam, The; Netherlands.; PURPOSE: Anorectal disease is commonly found in human immunodeficiency virus (HIV)-infected patients. The aim of this study was to determine the spectrum of anorectal disease, its surgical treatment, clinical outcome, and its relation to immune status. METHODS: Medical records of all HIV-infected patients with anorect
Decreased cell-mediated immunity in patients with non-insulin-dependent diabetes mellitus.: Diabetes Res Clin Pract. 1995 May;28(2):137-46. Unique Identifier : AIDSLINE MED/96030009; Chang FY; Shaio MF; Department of Internal Medicine, Tri-Service General Hospital,; National Defense Medical Center, Taipei, Taiwan, Republic of; China.; Peripheral blood mononuclear cells from patients with non-insulin-dependent diabetes mellitus (NIDDM) show reduced proliferative response to phytohemagglutinin (PHA) and other mitogens. This study was undertaken to determine whether this reduced lymphocyte proliferation is mediated by a decreased production of cytokin
Lymphatic distribution of 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine in mice.: Drug Metab Dispos. 1995 Jun;23(6):655-8. Unique Identifier : AIDSLINE MED/96075725; Manouilov KK; White CA; Boudinot FD; Fedorov II; Chu CK; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602-2353, USA.; Recently, it was shown that human immunodeficiency virus (HIV)-infected cells preferentially locate in lymphoid tissue early in the course of infection. Therefore, it is important to characterize the disposition of the anti-HIV agents, 3 -azido-3 -deoxythymidine (
Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human.: Drug Metab Dispos. 1995 Jul;23(7):688-95. Unique Identifier : AIDSLINE MED/96089969; Prueksaritanont T; Balani SK; Dwyer LM; Ellis JD; Kauffman LR; Varga SL; Pitzenberger SM; Theoharides AD; Department of Drug Metabolism, Merck Research Laboratories, West; Point, PA 19486, USA.; In vivo and in vitro metabolism of 6-chloro-4(S)-cyclopropyl-3,4-dihydro-4-((2-pyridyl) ethynyl)quinazolin-2(1H)-one (L-738,372), a potent human immunodeficiency virus-type 1 reverse transcriptase inhibitor, has been investigated in rats, dogs, and monkeys. Following 0.9 mg/kg iv and 9 mg/kg po doses, systemic blood c
pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs.: Drug Metab Dispos. 1995 Jul;23(7):730-5. Unique Identifier : AIDSLINE MED/96089976; Lin JH; Chen IW; Vastag KJ; Ostovic D; Merck Research Laboratories, West Point, PA 19486, USA.; L-735,524, a potent and specific inhibitor of human immunodeficiency virus protease, is currently under investigation for the treatment of acquired immunodeficiency syndrome. The aqueous solubility of L-735,524 was pH-dependent, > 100 mg/ml at pH below 3.5 and 0.03 mg/ml at pH 6. When L-735,524 was given orally as a s
[New knowledge on HIV pathogenesis (letter)]: Dtsch Med Wochenschr. 1995 Nov 17;120(46):1606. Unique Identifier : AIDSLINE MED/96084934; Harten P; Euler HH; Loffler H
A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.: Development. 1995 Oct;121(10):3393-403. Unique Identifier : AIDSLINE GENBANK/U31368; Staehling-Hampton K; Laughon AS; Hoffmann FM; McArdle Laboratory for Cancer Research, University of Wisconsin; Medical School, Madison 53706, USA.; Little is known about the signal transduction pathways by which cells respond to mammalian TGF-beta s or to decapentaplegic (dpp), a Drosophila TGF-beta-related factor. Here we describe the genetic and molecular characterization of Drosophila schnurri (shn), a putative transcription factor implicated in dpp signaling.
Atovaquone. A review of its pharmacological properties and therapeutic efficacy in opportunistic infections.: Drugs. 1995 Jul;50(1):176-96. Unique Identifier : AIDSLINE MED/96078265; Spencer CM; Goa KL; Adis International Limited, Auckland, New Zealand.; Atovaquone has been investigated as an alternative agent for oral use in the treatment of both mild to moderate Pneumocystis carinii pneumonia (PCP) and toxoplasmosis, opportunistic infections commonly experienced by patients with AIDS. In patients with mild to moderate PCP, a dosage of 750mg 3 times daily (administer
Guidelines for the use of zidovudine in pregnant women with HIV infection.: Drugs. 1995 Jul;50(1):43-7. Unique Identifier : AIDSLINE MED/96078258; De Santis M; Noia G; Caruso A; Mancuso S; Department of Obstetrics and Gynaecology, Catholic University of; the Sacred Heart, Rome, Italy.; Zidovudine therapy seems to be effective for reducing vertical transmission of HIV infection and preventing paediatric AIDS. Besides those cases in which it is indicated, zidovudine plays an important role in safeguarding maternal well-being. Even though no data indicating teratogenic effect of this drug exist, its us
Epidemiology of HIV infection among long distance truck drivers in Kenya.: East Afr Med J. 1995 Aug;72(8):515-8. Unique Identifier : AIDSLINE MED/96060425; Mbugua GG; Muthami LN; Mutura CW; Oogo SA; Waiyaki PG; Lindan CP; Hearst N; Kenya Medical Research Institute, Nairobi, Kenya.; A total number of two hundred eighty three long distance truck drivers and their assistants (loaders) who ferry goods between Kenya and Zaire were included in a cross-sectional study between September 1991 and April 1992. Twenty six percent of t
[Anxious-depressive state and cognitive deficit in HIV infection]: Encephale. 1995 Jul-Aug;21(4):285-8. Unique Identifier : AIDSLINE MED/96004061; Silvestre D; Linard F; Desi M; Seibel N; Korezlioglu J; Pequart C; Saimot AG; U158 INSERM, Hopital Necker-Enfants Malades, Paris.; This study tries to demonstrate the importance of using follow-up trials and taking anxio-depressive status into account while interpreting cognitive impairment in HIV-infected subjects. Subjects included were: 18 HIV carriers, mostly homosexual, belonging to CDC groups II (4), III or IVC2 (7) and IV (7), selected wit
[Cognition disorders in HIV infection. Validation of a brief neuropsychological evaluation battery]: Encephale. 1995 Jul-Aug;21(4):289-94. Unique Identifier : AIDSLINE MED/96004062; Desi M; Seibel N; Korezlioglu J; Silvestre D; Linard F; Service de Neurologie, Hopital de Bicetre, Le Kremlin-Bicetre.; The objective of our study was the elaboration and the validation of a brief neuropsychological battery sensitive to the main cognitive and psychomotor deficits in HIV+ patients with HIV encephalopathy and cognitive impairment associated with seropositivity. We evaluated the sensitivity of this brief battery with resp
Presumptive clinical criteria versus endoscopy in the diagnosis of Candida esophagitis at various HIV-1 disease stages.: Endoscopy. 1995 Jun;27(5):371-6. Unique Identifier : AIDSLINE MED/96026936; Antinori A; Antinori A; Ammassari A; Masetti R; De Luca A; Murri R; Tamburrini E; Magistrelli P; Department of Infectious Diseases, Catholic University, Rome,; Italy.; BACKGROUND AND STUDY AIMS: The presumptive diagnosis of Candida esophagitis has been included in the Centers for Disease Control (CDC) case definition for full-blown AIDS since 1987. Endoscopic examination should be reserved for patients showing symptoms despite treatment. The purpose of this study was to assess the d
Fluconazole vs. flucytosine in the treatment of esophageal candidiasis in AIDS patients: a double-blind, placebo-controlled study.: Endoscopy. 1995 Jun;27(5):377-83. Unique Identifier : AIDSLINE MED/96026937; Barbaro G; Barbarini G; Di Lorenzo G; Department of Emergency Medicine, La Sapienza University of Rome,; Italy.; BACKGROUND AND STUDY AIMS: Contrasting opinions exist as to the pharmacological treatment of esophageal candidiasis in human immunodeficiency virus (HIV)-positive patients. The aim of this study has been to evaluate the role, therapeutic efficacy, and the cost-benefit ratio of two antifungal drugs, fluconazole and flu
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.: EMBO J. 1995 Oct 16;14(20):5006-15. Unique Identifier : AIDSLINE MED/96067129; Lee CH; Leung B; Lemmon MA; Zheng J; Cowburn D; Kuriyan J; Saksela K; Laboratory of Molecular Biophysics, Rockefeller University, New; York, NY 10021, USA.; We have examined the differential binding of Hck and Fyn to HIV-1 Nef to elucidate the structural basis of SH3 binding affinity and specificity. Full-length Nef bound to Hck SH3 with the highest affinity reported for an SH3-mediated interaction (KD 250 nM). In contrast to Hck, affinity of the highly homologous Fyn SH3
Binding of human prothymosin alpha to the leucine-motif/activation domains of HTLV-I Rex and HIV-1 Rev.: Eur J Biochem. 1995 Oct 1;233(1):48-54. Unique Identifier : AIDSLINE MED/96061931; Kubota S; Adachi Y; Copeland TD; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis,; NCI-Frederick Cancer Research and Development Center, MD 21702,; USA.; Rex of human T-cell leukemia virus type I (HTLV-I) and Rev of human immunodeficiency virus 1 (HIV-1) are post-transcriptional regulators of viral gene expression. By means of affinity chromatography, we purified an 18-kDa cellular protein that bound to the conserved leucine-motif/activation domain of HTLV-I Rex or HIV
Role of antigenemia assay in the early diagnosis and prediction of human cytomegalovirus organ involvement in AIDS patients.: Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):498-503. Unique Identifier : AIDSLINE MED/96082793; Francisci D; Tosti A; Preziosi R; Baldelli F; Stagni G; Pauluzzi S; Institute of Infectious Diseases, University of Perugia,; Policlinico Monteluce, Italy.; The role of an antigenemia assay in the diagnosis and prediction of human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The clinical history of 62 patients with advanced HIV infection from whom a total of 248 blood samples were drawn and tested by the HCMV antigene
Longitudinal study of cytomegalovirus antibodies in individuals infected with the human immunodeficiency virus.: Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):504-11. Unique Identifier : AIDSLINE MED/96082794; Flo RW; Haukenes G; Nilsen A; Skjaerven R; Forsgren M; Fehniger TE; Medical Department B, Haukeland Hospital, University of Bergen,; Norway.; Cytomegalovirus ( CMV ) antibody profiles were studied in 25 HIV-infected patients over periods of up to 56 months. Specific antibodies against CMV antigen components were monitored by complement-fixation (CF) test, EIA, Western blot and a neutralization assay. Th
Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.: Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):512-9. Unique Identifier : AIDSLINE MED/96082795; Calderon EJ; Torres Y; Medrano FJ; Luque F; Larder B; Rey C; Sanchez-Quijano A; Lissen E; Leal M; Department of Internal Medicine, Virgen del Rocio University; Hospital, Seville, Spain.; The dynamics leading to the emergence of a zidovudine-resistant mutation at codon 215 of the reverse transcriptase coding region was investigated in a cohort of HIV-infected individuals who received early zidovudine therapy. Clinical implications and the role of the resistance mutation at codon 41 were also assessed.
Catheter-related cutaneous aspergillosis complicated by fungemia and fatal pulmonary infection in an HIV-positive patient with acute lymphocytic leukemia.: Eur J Clin Microbiol Infect Dis. 1995 Jun;14(6):524-6. Unique Identifier : AIDSLINE MED/96082797; Girmenia C; Gastaldi R; Martino P; Department of Human Biopathology, University La Sapienza, Rome,; Italy.; A case of intravenous catheter-related cutaneous aspergillosis and Aspergillus fumigatus fungemia in an HIV-positive patient with Burkitt-cell acute lymphocytic leukemia is reported. The patient developed pulmonary aspergillosis with a rapidly fatal outcome despite recovery from neutropenia and improvement of the unde
Value of specific immunoglobulin A detection by two immunocapture assays in the diagnosis of toxoplasmosis.: Eur J Clin Microbiol Infect Dis. 1995 Jul;14(7):585-90. Unique Identifier : AIDSLINE MED/96047083; Foudrinier F; Marx-Chemla C; Aubert D; Bonhomme A; Pinon JM; Laboratoire de Parasitologie-Mycologie, Institut National de la; Sante et de la Recherche Medicale U314, Centre Hospitalier; Universitaire, Hopital Maison Blanche, Reims, France.; The diagnosis of Toxoplasma gondii infection is currently based on immunological tests, but tests for IgG and IgM antibodies alone are often insufficient to assess the risk of active disease, especially during pregnancy and in immunodeficient subjects. The supplementary diagnostic value of testing for antitoxoplasmic
Association between HIV and other DNA viruses in vitro.: Eur J Clin Microbiol Infect Dis. 1995 Jul;14(7):591-6. Unique Identifier : AIDSLINE MED/96047084; Cisterna R; Campelo C; Gorrino T; Malave C; Sarria L; Lardelli P; Fernandez de Aranguiz A; Madariaga L; Immunology, Microbiology and Parasitology Department, University; of Basque Country, Bilbao, Spain.; To investigate the association of human immunodeficiency virus (HIV) with various DNA viruses, including hepatitis B virus (HBV), cytomegalovirus ( CMV ) and Epstein-Barr virus, (EBV), simultaneous detection of HIV p24 antigen,
Detection of HIV-1 proviral sequences in lymphocytes using a qualitative polymerase chain reaction assay.: Eur J Clin Microbiol Infect Dis. 1995 Jul;14(7):621-5. Unique Identifier : AIDSLINE MED/96047093; Marin MG; Lillo F; Varnier OE; Bresciani S; Molinelli A; Abecasis C; Bonini PA; Albertini A; Institute of Chemistry, School of Medicine, University of; Brescia, Spedali Civili, Italy.; The performance and clinical relevance of a qualitative PCR-based assay for the detection of HIV-1 DNA sequences in peripheral blood mononuclear cells (PBMCs) was evaluated by two different laboratories. Four hundred and one samples were obtained from 397 individuals from different risk populations. All blood donors t
Pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus infection.: Eur J Clin Pharmacol. 1995;48(3-4):291-3. Unique Identifier : AIDSLINE MED/96037144; Nahata MC; Brady MT; College of Pharmacy, Ohio State University, Wexner Institute for; Pediatric Research, Children's Hospital, Columbus 43210, USA.; The objective of this study was to determine the pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus (HIV) infection. After an overnight fast, a single dose of either 2 mg.kg-1 or 8 mg.kg-1 was administered in a suspension; five children received 2 mg.kg-1 and four 8
A B7-1-transfected human melanoma line stimulates proliferation and cytotoxicity of autologous and allogeneic lymphocytes.: Eur J Immunol. 1995 Oct;25(10):2737-42. Unique Identifier : AIDSLINE MED/96062018; Sule-Suso J; Arienti F; Melani C; Colombo MP; Parmiani G; Division of Experimental Oncology D, Istituto Nazionale Tumori,; Milan, Italy.; B7 co-stimulation is necessary to activate resting T cells upon antigen recognition by the T cell receptor. To see whether expression of B7 may render human melanoma cells able to stimulate T cells, a cloned melanoma line (Me1B6), which did not express B7-1, was transfected with the human B7-1 gene. In proliferation a
Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells.: Eur J Immunol. 1995 Oct;25(10):2743-51. Unique Identifier : AIDSLINE MED/96062019; Hiroi T; Fujihashi K; McGhee JR; Kiyono H; Department of Oral Biology, University of Alabama at Birmingham; Medical Center 35294-2170, USA.; Currently only limited information is available as to why dominant IgA isotype responses are supported by mucosal T cells in effector tissues. To address this issue directly, gamma delta and alpha beta T cells were isolated from the submandibular gland (SMG) of mice as an example of mucosal effector tissues. Freshly i
Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunization with ISCOMS.: Eur J Immunol. 1995 Oct;25(10):2835-41. Unique Identifier : AIDSLINE MED/96062033; Maloy KJ; Donachie AM; Mowat AM; Department of Immunology, University of Glasgow, Western; Infirmary, Scotland.; We examined the ability of oral or parenteral immunization with immune stimulating complexes containing ovalbumin (ISCOMS-OVA) to prime T cell proliferative and cytokine responses. A single subcutaneous immunization with ISCOMS-OVA primed potent antigen-specific proliferative responses in the draining popliteal lymph
Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations.: Eur J Immunol. 1995 Oct;25(10):2907-16. Unique Identifier : AIDSLINE MED/96062044; Tuosto L; Montani MS; Lorenzetti S; Cundari E; Moretti S; Lombardi G; Piccolella E; Department of Cellular and Developmental Biology, University La; Sapienza, Rome, Italy.; To support the hypothesis that indirect mechanisms mediated by viral products like the HIV envelope glycoprotein gp120 could be responsible for T lymphocyte depletion in HIV infection, we developed a system in which the impairment of T cell functions could be investigated in vitro. In particular, we characterized the
Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.: Eur J Immunol. 1995 Oct;25(10):2917-22. Unique Identifier : AIDSLINE MED/96062045; Tuosto L; Piazza C; Moretti S; Modesti A; Greenlaw R; Lechler R; Lombardi G; Piccolella E; Department of Cellular and Developmental Biology, University La; Sapienza, Rome, Italy.; Temporal or quantitative imbalance in signals delivered to T cells via T cell antigen receptor (TCR), the CD4 co-receptor, and accessory molecules can lead to anergy, apoptosis, or both. This has been observed following ligation of CD4 by HIV gp120 prior to TCR occupancy. The ability of molecules such as CD2 and CD28,
CD40 ligand-positive CD8+ T cell clones allow B cell growth and differentiation.: Eur J Immunol. 1995 Oct;25(10):2972-7. Unique Identifier : AIDSLINE MED/96062053; Hermann P; Van-Kooten C; Gaillard C; Banchereau J; Blanchard D; Schering-Plough, Laboratory for Immunological Research, Dardilly,; France.; A fraction of activated CD8+ T cells expresses CD40 ligand (CD40L), a molecule that plays a key role in T cell-dependent B cell stimulation. CD8+ T cell clones were examined for CD40L expression and for their capacity to allow the growth and differentiation of B cells, upon activation with immobilized anti-CD3. Accord
Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction.: Eur J Immunol. 1995 Sep;25(9):2421-7. Unique Identifier : AIDSLINE MED/96011846; Kanagawa O; Vaupel BA; Korsmeyer SJ; Russell JH; Department of Pathology, Washington School of Medicine, St.; Louis, MO 63110, USA.; Murine acquired immunodeficiency syndrome (MAIDS) is caused by a defective murine leukemia virus. The disease is characterized by abnormal lymphoproliferation, impaired T and B cell function and aberrant regulation of cytokines. Both T and B lymphocytes show activated phenotypes, but undergo apoptotic death with chara
Evidence for Th2 cell-mediated suppression of antibody responses in transgenic, beef insulin-tolerant mice.: Eur J Immunol. 1995 Sep;25(9):2522-7. Unique Identifier : AIDSLINE MED/96011861; Teng YT; Gorczynski RM; Iwasaki S; Williams DB; Hozumi N; Samuel Lunenfeld Research Institute, Mount Sinai Hospital,; Toronto, Canada.; Clonal deletion, anergy and suppression have all been considered mechanisms of immunological tolerance. Although adoptive transfer of immunosuppression has been shown to occur in the periphery, particularly for transplantation tolerance, it has proven difficult to characterize this phenomenon further, due to the lack
CD8+ type 1 CD44hi CD45 RBlo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I- and class II-deficient mice.: Eur J Immunol. 1995 Sep;25(9):2551-7. Unique Identifier : AIDSLINE MED/96011866; Oliveira SC; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin, Madison 53706, USA.; Genetically engineered mice with a targeted disruption in the beta 2-microglobulin (beta 2-m) gene or the H2-I-A beta chain (A beta) which lack functional CD8+ or CD4+ T cells, respectively, were used to assess the role of T cell subsets in Brucella abortus infection. Murine brucellosis was markedly exacerbated in bet
Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.: Eur J Immunol. 1995 Sep;25(9):2572-7. Unique Identifier : AIDSLINE MED/96011869; Kneitz B; Herrmann T; Yonehara S; Schimpl A; Institute of Virology and Immunobiology, Wurzburg, Germany.; Despite a normal development of all major lymphoid subsets, with time, interleukin-2 ( IL-2 )-deficient mice develop a fatal immunopathology. The disease phenotype is characterized by lymphoadenopathy, splenomegaly, T cell infiltration of various organs, overproduction o
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis.: Eur J Immunol. 1995 Sep;25(9):2618-25. Unique Identifier : AIDSLINE MED/96011876; Simpson SJ; Mizoguchi E; Allen D; Bhan AK; Terhorst C; Division of Immunology Beth Israel Hospital, Harvard Medical; School, Boston, MA 02215, USA.; Mice deficient in interleukin-2 production (IL-2null mice) develop colonic inflammation closely resembling ulcerative colitis in humans. Although this disease is marked by substantial infiltration of the colon by CD8+ and CD4+ T lymphocytes, no function has yet been assigned to these T cell subsets in the development
Quantitation of endogenous mouse mammary tumor virus superantigen expression by lymphocyte subsets.: Eur J Immunol. 1995 Sep;25(9):2632-7. Unique Identifier : AIDSLINE MED/96011878; Waanders GA; Lees RK; Held W; MacDonald HR; Ludwig Institute for Cancer Research, Lausanne Branch, University; of Lausanne, Epalinges, Switzerland.; Superantigens (SAg) encoded by endogenous mouse mammary tumor viruses (Mtv) interact with the V beta domain of the T cell receptor (TcR-V beta). Presentation of Mtv SAg can lead to stimulation and/or deletion of the reactive T cells, but little is known about the quantitative aspects of SAg presentation. Although mono
Down-modulation of CD4+ T helper type 2 and type 0 cells by T helper type 1 cells via Fas/Fas-ligand interaction.: Eur J Immunol. 1995 Sep;25(9):2679-85. Unique Identifier : AIDSLINE MED/96011886; Hahn S; Stalder T; Wernli M; Burgin D; Tschopp J; Nagata S; Erb P; Institute for Medical Microbiology, University of Basel,; Switzerland.; Fas was recently demonstrated to be the major target molecule engaged by CD4+ cytolytic T lymphocytes (CTL). We examined Fas expression on various cloned T cell subpopulations and their susceptibility to lysis by CD4+ or CD8+ CTL. A reciprocal relationship in Fas and Fas-ligand expression was observed in CD4+ T helper
Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.: Eur J Immunol. 1995 Sep;25(9):2695-700. Unique Identifier : AIDSLINE MED/96011888; Zauli G; Previati M; Caramelli E; Bassini A; Falcieri E; Gibellini D; Bertolaso L; Bosco D; Robuffo I; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; We investigated the effect of extracellular Tat protein of human immunodeficiency virus-type 1 (HIV-1) on the phosphatidylinositol (PI) cycle, which represents a major signal transduction pathway in lymphoid cells. Recombinant Tat, recombinant HIV-1 p24 and cross-linked anti-CD3 monoclonal antibody (mAb) were added in
Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions.: Eur J Immunol. 1995 Sep;25(9):2722-5. Unique Identifier : AIDSLINE MED/96011894; Demeure CE; Yang LP; Byun DG; Ishihara H; Vezzio N; Delespesse G; University of Montreal, Louis-Charles Simard Research Center,; Notre-Dame Hospital, Canada.; The maturation of naive CD4 T cells into interleukin (IL)-4-producing effectors was shown to require the presence of IL-4 at priming, the cellular origin of which remains unclear. We demonstrate here that naive T cells themselves release IL-4 at very low levels that are nevertheless sufficient to promote their develop
HIV-related non-Hodgkin's lymphoma among European AIDS patients. AIDS in Europe Study Group. AIDS in Europe Study Group.: Eur J Haematol. 1995 Oct;55(4):245-50. Unique Identifier : AIDSLINE MED/96013862; Pedersen C; Barton SE; Chiesi A; Skinhoj P; Katlama C; Johnson A; van Lunzen J; Hirschel B; Maayan S; Lundgren JD; Department of Infectious Disease, State University Hospital,; Copenhagen, Denmark.; The epidemiology of HIV associated non-Hodgkin s lymphoma (NHL) was investigated in 6550 European patients with AIDS. NHL was diagnosed in 3.5% of all patients at the time of the AIDS diagnosis. Although the probability of being diagnosed with NHL at AIDS diagnosis was significantl
Cardiac tamponade: the first manifestation of a generalized lymphoma in a patient with HIV infection [letter]: Eur J Haematol. 1995 Oct;55(4):274. Unique Identifier : AIDSLINE MED/96013868; Van Vooren JP; Renard M; Dargent JL; Capel P; Feremans WW; Farber CM
Knowledge and perceptions of emergency contraceptive pills among a college-age population: a qualitative approach.: Fam Plann Perspect. 1995 Jul-Aug;27(4):149-54. Unique Identifier : AIDSLINE MED/96002893; Harper C; Ellertson C; Office of Population Research, Princeton University, USA.; Results from focus-group discussions with a population of university students who have convenient access to emergency contraceptive pills show that basic awareness about this method is high, although specific knowledge on appropriate use, such as the time limit for use, the level of effectiveness and the possible side
Bronchiolitis obliterans organizing pneumonia in an AIDS patient.: Eur Respir J. 1995 Jun;8(6):1021-4. Unique Identifier : AIDSLINE MED/96059576; Sanito NJ; Morley TF; Condoluci DV; Dept of Pulmonary Medicine, University of Medicine and Dentistry; of New Jersey, School of Osteopathic Medicine, Stratford, New; Jersey, USA.; We present a case of bronchiolitis obliterans organizing pneumonia in a patient with acquired immune deficiency syndrome. Only three cases have previously been reported in patients infected with human immunodeficiency virus. In these four cases, bronchiolitis obliterans organizing pneumonia was similar in presentation
Drug resistant tuberculosis: back to sanatoria, surgery and cod-liver oil? [editorial; comment]: Eur Respir J. 1995 Jul;8(7):1073-5. Unique Identifier : AIDSLINE MED/96016581; Veen J
Drug-resistant tuberculosis in the 1990s [see comments]: Eur Respir J. 1995 Jul;8(7):1184-92. Unique Identifier : AIDSLINE MED/96016596; Yew WW; Chau CH; Tuberculosis & Chest Unit, Grantham Hospital, Aberdeen, Hong; Kong.; There has been an upsurge of tuberculosis in many parts of the world in the past decade. The high rates of drug-resistant tuberculosis currently reported in many countries are alarming. The most catastrophic phenomenon is the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. These organisms have
DNA synthesis primed by mononucleotides (de novo synthesis) catalyzed by HIV-1 reverse transcriptase: tRNA(Lys,3) activation.: FEBS Lett. 1995 Oct 16;373(3):255-8. Unique Identifier : AIDSLINE MED/96033984; Zakharova OD; Tarrago-Litvak L; Fournier M; Litvak S; Nevinsky GA; Institute of Bioorganic Chemistry, Siberian Division of the; Academy of Sciences of Russia, Novosibirsk, Russian Federation.; HIV-1 RT is able to catalyze DNA synthesis starting from mononucleotides used both as minimal primers and as nucleotide substrates (de novo synthesis) in the presence of a complementary template. The rate of this process is rather slow when compared to the polymerization primed by an oligonucleotide. The addition of t
The complete Consensus V3 loop peptide of the envelope protein gp120 of HIV-1 shows pronounced helical character in solution.: FEBS Lett. 1995 Oct 23;374(1):117-21. Unique Identifier : AIDSLINE MED/96049568; Vranken WF; Budesinsky M; Fant F; Boulez K; Borremans FA; Department of Organic Chemistry, University of Gent, Belgium.; The disulfide bridge closed cyclic peptide corresponding to the whole Consensus V3 loop of the envelope protein gp120 of HIV-1 was examined by proton 2D-NMR spectroscopy in water and in a 20% trifluoroethanol/water solution. In water, NOE data support a beta-turn conformation for the central conservative GPGR region a
T-cell mediated immunosuppression and its implications for the development of protective immunity.: Folia Biol (Praha). 1994;40(6):349-58. Unique Identifier : AIDSLINE MED/96037164; Baker PJ; Hraba T; Division of Microbiology and Infectious Diseases, National; Institute of Allergy and Infectious Diseases, National Institutes; of Health, Bethesda, Maryland 20892, USA.; The mechanisms by which regulatory CD4- CD8+ suppressor T cells (Ts) and CD4+ CD8- amplifier T cells (Ta) influence the magnitude of the antibody response to the capsular polysaccharide antigen of type III Streptococcus pneumoniae are reviewed in detail. This represents the best-characterized experimental model system
Aberrant activation of CD8+ T-cell and CD8+ T-cell subsets in patients with newly diagnosed IDDM.: Diabetes. 1995 Dec;44(12):1414-9. Unique Identifier : AIDSLINE MED/96082212; Hehmke B; Michaelis D; Gens E; Laube F; Kohnert KD; Department of Experimental and Clinical Endocrinology, University; of Greifswald, Karlsburg, Germany.; Two- and three-color cytofluorimetric techniques were used to study the expression patterns of the activation antigen HLA-DR on peripheral blood immunoregulatory T-cells from 25 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) and 14 age- and sex-matched control subjects. The mean percentage of
[Hepatic peliosis, a still current disease (editorial)]: Gastroenterol Clin Biol. 1995 May;19(5):505-7. Unique Identifier : AIDSLINE MED/96008766; Scoazec JY
[Peliosis hepatitis during intestinal lymphomatous polyposis treated with chemotherapy and radiotherapy. Regression after antibiotic therapy]: Gastroenterol Clin Biol. 1995 May;19(5):537-41. Unique Identifier : AIDSLINE MED/96008772; Abdelli N; Bouhnik Y; Lavergne-Slove A; Messing B; Galian A; Rambaud JC; Service d'Hepato-Gastroenterologie et d'Assistance Nutritive,; Hopital Saint-Lazare, Paris.; We report a case of regressive peliosis hepatis, which occurred in a 55 year-old woman with diffuse intestinal lymphomatous polyposis in remission after treatment with chemotherapy and radiotherapy, and which was cleared after one month treatment with erythromycin. The Warthin-Sarry stain, performed to identify a spec
Enhanced and coordinated processing of synapsed viral DNA ends by retroviral integrases in vitro.: Genes Dev. 1995 Oct 15;9(20):2556-67. Unique Identifier : AIDSLINE MED/96033805; Kukolj G; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111, USA.; We have designed novel substrates to investigate the first step in retroviral integration: the site-specific processing of two nucleotides from the 3 ends of viral DNA. The substrates consist of short duplex oligodeoxynucleotides whose sequences match those of the U3 and U5 ends of viral DNA but are covalently synaps
The role of oxidative stress in HIV disease.: Free Radic Biol Med. 1995 Oct;19(4):523-8. Unique Identifier : AIDSLINE MED/96015038; Pace GW; Leaf CD; Research Triangle Pharmaceuticals, Durham, NC, USA.; Evidence has accumulated suggesting that HIV-infected patients are under chronic oxidative stress. Perturbations to the antioxidant defense system, including changes in levels of ascorbic acid, tocopherols, carotenoids, selenium, superoxide dismutase, and glutathione, have been observed in various tissues of these pat
[Effect of interferon alpha on immunologic parameters in patients with carcinoma of the renal parenchyma]: Glas Srp Akad Nauka [Med]. 1994;(44):101-8. Unique Identifier : AIDSLINE MED/96021699; Markinovic M; Jelic S; Milosevic D; Kovcin V; Spuzic I; Institute of Oncology and Radiology, Beograd.; A wide range of immunological abnormalities have been described in renal-cell carcinoma (RCC). The only constant one was the decrease of CD4/CD8 ratio, reversible following radical nephrectomy in the absence of metastases. Alpha-interferon was administered with variable benefit to patients with metastatic RCC. The aim
[Therapeutic possibilities of recombinant interferon alfa-2b (Intron A) in non-AIDS Kaposi sarcomas and angiosarcomas]: Glas Srp Akad Nauka [Med]. 1994;(44):117-25. Unique Identifier : AIDSLINE MED/96021701; Jelic S; Vuletic L; Filipovic I; Milanovic N; Tomasevic Z; Marinkovic M; Institute of Oncology and Radiology, Belgrade.; Data concerning treatment of vascular neoplasia with biological response modifiers are still scanty, but encouraging results have been observed with alpha-2b interferon in AIDS related Kaposi sarcoma. In this study five treatment naive patients with Kaposi sarcoma and four heavily pretreated patients with angiosarcoma
[The role of T-lymphocyte subsets in susceptibility and resistance to induction of autoimmunity in the central nervous system]: Glas Srp Akad Nauka [Med]. 1994;(44):35-43. Unique Identifier : AIDSLINE MED/96021692; Mostarica-Stojkovic M; Vukmanovic S; Radojkovic M; Ramic Z; Vuckovic S; Ejdus L; Pravica V; Simic MM; Lukic ML; Institute of Microbiology and Immunology, School of Medicine,; University of Belgrade.; The importance of two major subsets of T cells (CD4 and CD8) for the induction of EAE was analysed in two strains of rats differing in susceptibility to EAE and the level of IL 2 production. It was found that CD8 cells do not play a role in the induction or in the inherent resistance to EAE. Additionally, the eliminat
[Human fetal pancreatic islet transplantation in insulin-dependent diabetics: possibilities of early detection of transplant destruction]: Glas Srp Akad Nauka [Med]. 1994;(44):83-8. Unique Identifier : AIDSLINE MED/96021697; Djordjevic PB; Brkic S; Lalic NM; Zamaklar M; Dragasevic M; Radovic Z; Popovic S; Banovic D; Dimitrijevic V; Savic K; et al; Institute for Endocrinology, Diabetes and Metabolic Diseases,; University Clinical Center, Belgrade, Yugoslavia.; The factors determining the outcome of human fetal islet transplantation in patients with insulin-dependent diabetes mellitus (IDDM) remain unclarified. In this study we analysed the ratio between immunoregulatory lymphocyte subpopulations in order to search for a possible marker of the immune destruction of transplan
CD30 molecule (Ki-1 Ag): more than just a marker of CD30+ lymphoma.: Haematologica. 1995 Jul-Aug;80(4):357-66. Unique Identifier : AIDSLINE MED/96019520; Pizzolo G; Romagnani S; Cattedra di Ematologia, University of Verona, Italy.
[Production of HTLV-II env protein and its suppressive effect on infection]: Hokkaido Igaku Zasshi. 1995 Jul;70(4):635-47. Unique Identifier : AIDSLINE MED/96080920; Kawamura N; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.; HTLV-II env protein, which cross-reacts with HTLV-I env, has been known to induce antibodies in infected individuals. In an attempt to suppress HTLV-II infection, we first generated HTLV-II env precursor glycoprotein (gp63) using baculovirus vector and the Sf-9 cell system. The production of antibodies to the cleaved
Glucocorticoid reserve in patients with acquired immunodeficiency syndrome.: Horm Res. 1995;44(2):85-8. Unique Identifier : AIDSLINE MED/96022620; Peter SA; Bruschetta H; Vergara R; Department of Medicine, Woodhull Medical and Mental Health; Center, Brooklyn, N.Y., USA.; The purpose of the study was to determine the glucocorticoid reserve in patients with AIDS. Thirty patients with AIDS, who were not critically ill, were chosen consecutively and studied prospectively over a 1-year period with cosyntropin-stimulation testing. All patients showed normal glucocorticoid response to cosynt
Human immunodeficiency virus-associated Hodgkin's disease contains latent, not replicative, Epstein-Barr virus.: Hum Pathol. 1995 Nov;26(11):1191-5. Unique Identifier : AIDSLINE MED/96068778; Siebert JD; Ambinder RF; Napoli VM; Quintanilla-Martinez L; Banks PM; Gulley ML; Department of Pathology, University of Texas Health Science; Center, San Antonio 78284-7750, USA.; Severe immunodeficiency is associated with reactivation of latent Epstein-Barr virus (EBV) that is manifested by virus replication. It is unknown whether EBV replication also occurs in the Hodgkin s disease (HD) tissue of patients infected with the human immunodeficiency virus (HIV). Therefore, we studied paraffin-emb
Should screening of genital infections be part of antenatal care in areas of high HIV prevalence? A prospective cohort study from Kigali, Rwanda, 1992-1993. The Pregnancy and HIV (EGE) Group.: Genitourin Med. 1995 Aug;71(4):207-11. Unique Identifier : AIDSLINE MED/96046495; Leroy V; De Clercq A; Ladner J; Bogaerts J; Van de Perre P; Dabis F; INSERM U. 330, Universite de Bordeaux II, France.; OBJECTIVE--To study the prevalence and incidence of genital infections and their association with HIV-1 infection among pregnant women in Kigali, Rwanda . SUBJECTS AND METHODS--HIV+ and HIV- pregnant women were followed prospectively during the last three months of pregnancy. At enr
HIV-1 incidence and HIV-1 associated mortality in a cohort of urban factory workers in Tanzania.: Genitourin Med. 1995 Aug;71(4):212-5. Unique Identifier : AIDSLINE MED/96046496; Borgdorff MW; Barongo LR; Klokke AH; Newell JN; Senkoro KP; Velema JP; Gabone RM; National Institute for Medical Research, Mwanza, Tanzania.; OBJECTIVE--To determine HIV-1 incidence and HIV-1 associated mortality in a prospective cohort study. To determine whether the cohort is suitable for studies aiming to determine the impact of interventions on HIV-1 incidence. METHODS--The study population was a cohort of 1772 urban factory workers (1478 men and 294 wo
HIV/AIDS knowledge and high risk sexual practices among southern California Vietnamese.: Genitourin Med. 1995 Aug;71(4):216-23. Unique Identifier : AIDSLINE MED/96046497; Gellert GA; Maxwell RM; Higgins KV; Mai KK; Lowery R; Doll L; Project HOPE Health Sciences Education Center, Millwood, VA; 22646, USA.; OBJECTIVES--Vietnamese immigration to the U.S. since the conclusion of the Vietnam war has been substantial and in Orange County, CA, Vietnamese Americans comprise 3% of the population (the largest community in the US). Our objective was to collect data on the HIV/AIDS knowledge, attitudes and self-reported high risk
Non surgical treatment of empyema thoracis with intrapleural streptokinase in a patient with AIDS.: Genitourin Med. 1995 Aug;71(4):259-61. Unique Identifier : AIDSLINE MED/96046508; Miller RF; Severn A; Department of Medicine, University College London Medical School,; Middlesex Hospital Site, UK.; After unsuccessful treatment with intercostal tube drainage and antibiotics intrapleural streptokinase was used to treat successfully an empyema in a man with AIDS and advanced cutaneous Kaposi s sarcoma who was unfit for surgical decortication. The role of this technique in the management of HIV positive patients wit
Herpes simplex virus type 2 encephalitis and concomitant cytomegalovirus infection in a patient with AIDS: detection of virus-specific DNA in CSF by nested polymerase chain reaction.: Genitourin Med. 1995 Aug;71(4):262-4. Unique Identifier : AIDSLINE MED/96046509; Miller RF; Fox JD; Waite JC; Severn A; Brink NS; Department of Medicine, University College London Medical School,; Middlesex Hospital, London, UK.; A Caucasian homosexual man with AIDS and cytomegalovirus retinitis presented with facial pain and episodic confusion, had several seizures and became obtunded. An electroencephalogram was suggestive of herpes simplex encephalitis. The diagnosis was confirmed by detection of herpes
Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18.: Genomics. 1995 Jul 1;28(1):101-4. Unique Identifier : AIDSLINE MED/96070439; Willenbrink W; Halaschek J; Schuffenhauer S; Kunz J; Steinkasserer A; Sandoz Research Institute, Vienna, Austria.; Cyclophilin A (CyP-A), the major intracellular receptor for the immunosuppressant cyclosporin A (CsA), is a member of the immunophilin class of proteins, which all possess peptidyl-prolyl cis-trans isomerase activity and, therefore, are believed to be involved in protein folding and/or intracellular protein transport.
Mouse monoclonal antibodies to human immunodeficiency virus glycoprotein 120 generated by repeated immunization with glycoprotein 120 from a single isolate, or by sequential immunization with glycoprotein 120 from three isolates.: Hybridoma. 1995 Jun;14(3):235-42. Unique Identifier : AIDSLINE MED/96082393; Reeves JP; Lo CY; Klinman DM; Epstein SL; Laboratory of Molecular Immunology, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; Mouse hybridomas were isolated that produce monoclonal antibodies (MAbs) to several regions of the HIV envelope, gp120, which may be used to map immunogenic regions in animal and human immunity. One series of MAbs was generated by repeated immunization with recombinant gp120 (rgp120) from a single isolate, and a secon
Factors influencing safer sexual behaviors in heterosexual late adolescent and young adult collegiate males.: Image J Nurs Sch. 1995 Fall;27(3):217-23. Unique Identifier : AIDSLINE MED/96068412; Cole FL; Slocumb EM; University of Texas-Houston Health Science Center, School of; Nursing 77030, USA.; An exploratory study examined variables characterized as predisposing to the practice of safe sexual behaviors. A sample of 227 male subjects from a state-supported university in southeastern New England returned questionnaires anonymously that contained demographic questions and instruments to measure the study varia
Serum nitrite plus nitrate in infection with human immunodeficiency virus type-1.: Immunobiology. 1995 Jun;193(1):59-70. Unique Identifier : AIDSLINE MED/96100679; Zangerle R; Fuchs D; Reibnegger G; Werner-Felmayer G; Gallati H; Wachter H; Werner ER; Department of Dermatology and Venereology, University of; Innsbruck, Ludwig Boltzmann Institute of AIDS Research, Austria.; To get a measure of the extent of induction of nitric oxide synthase in infection with human immunodeficiency virus type-1 (HIV-1) in vivo, we estimated serum nitrite plus nitrate concentrations in 110 HIV-1 infected individuals compared to 76 blood donors. To monitor cytokine action and to measure induction of pterid
Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV-1.: Immunobiology. 1995 Jun;193(1):98-113. Unique Identifier : AIDSLINE MED/96100682; Stoiber H; Schneider R; Janatova J; Dierich MP; Ludwig Boltzmann Institute for AIDS Research, University of; Innsbruck, Austria.; Recently we reported the basic phenomenon of an interaction between the envelope glycoproteins of HIV-1 gp120 and gp41 and components of the human complement system, i.e. activated C4 (C4b) and activated C3 (C3b) and the complement regulator proteins factor H and properdin. In this study we analyze these interactions
Human lactoferrin induces phenotypic and functional changes in murine splenic B cells.: Immunology. 1995 Sep;86(1):122-7. Unique Identifier : AIDSLINE MED/96091081; Zimecki M; Mazurier J; Spik G; Kapp JA; Institute of Immunology and Experimental Therapy, Polish Academy; of Sciences, Wroclaw, Poland.; The immunotropic activities of human lactoferrin were studied with respect to phenotypic and functional changes in murine splenic B cells. Phenotypic changes were induced by human lactoferrin in splenic B-cell fractions separated by buoyant density. B cells from 7-8-day-old BALB/c mice isolated from a 50/60% Percoll g
Establishment of T-helper type 1- and T-helper type 2-like human Toxoplasma antigen-specific T-cell clones.: Immunology. 1995 Sep;86(1):79-84. Unique Identifier : AIDSLINE MED/96091075; Daubener W; Mackenzie C; Hadding U; Institut fur Medizinische Mikrobiologie und Virologie,; Heinrich-Heine-Universitat, Dusseldorf, Germany.; As an in vitro model for human cerebral toxoplasmosis, we analysed the interaction between glioblastoma cells, Toxoplasma and Toxoplasma antigen-specific T-helper cells. We established 46 different human CD4+ T-cell clones from four different donors. All T-cell clones responded to Toxoplasma antigen derived from three
Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells.: Immunology. 1995 Sep;86(1):85-96. Unique Identifier : AIDSLINE MED/96091076; Vyakarnam A; Matear PM; Martin SJ; Wagstaff M; Department of Immunology, University College London Medical; School, UK.; This report provides three lines of evidence to suggest that T-helper type 1 (Th1) and type 0 (Th0) cells could play an opposing role in acquired immune deficiency syndrome (AIDS). Using a panel of Th1 and Th0 clones specific for human immunodeficiency virus-1 (HIV-1) gag p24, derived from seronegative volunteers immu
Increased level of activated gamma delta lymphocytes correlates with disease severity in HIV infection.: Immunol Cell Biol. 1995 Jun;73(3):245-8. Unique Identifier : AIDSLINE MED/96082312; Norazmi MN; Arifin H; Jamaruddin MA; Department of Immunology, School of Medical Sciences, Universiti; Sains Malaysia, Kelantan.; The lymphocyte subset expressing the gamma delta T cell receptor is increased in several infectious diseases including HIV infection. In this study the expression on gamma delta lymphocytes of the T cell activation markers CD25, HLA-DR and CD38, as well as the two isoforms of CD45, namely CD45RA and CD45RO, was determ
Mac1 discriminates unusual CD4-CD8- double-negative T cells bearing alpha beta antigen receptor from conventional ones with either CD4 or CD8 in murine lung.: Immunol Lett. 1995 May;46(1-2):143-52. Unique Identifier : AIDSLINE MED/96078168; Kawakami K; Teruya K; Tohyama M; Kudeken N; Yonamine Y; Saito A; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt
Reduced CD21 (CR2) and CD54 (ICAM-1) expression in MT2 cells with HIV-1 or HIV-2 strains.: Immunol Lett. 1995 May;46(1-2):31-6. Unique Identifier : AIDSLINE MED/96078150; Larcher C; Julen N; Prodinger WM; Totsch M; Gurtler L; Dierich MP; Institut fur Hygiene, Universitat Innsbruck, Austria.; Alterations in the expression of cell-surface receptors have been reported in HIV-infected cells for CD4, CD25 ( IL-2 receptor), CD2, CD3 and CD8 and CD26. In the present study we provide evidence that CD21 is down-regulated in the human T-lymphoblastoid cell line MT2 a
Acute Plasmodium falciparum infection is associated with increased percentages of apoptotic cells.: Immunol Lett. 1995 May;46(1-2):59-62. Unique Identifier : AIDSLINE MED/96078154; Balde AT; Sarthou JL; Roussilhon C; Unite d'Immunologie, Institut Pasteur, Dakar, Senegal, West; Africa.; The impact of acute malaria infection on the level of spontaneous apoptosis, i.e., the percentage of apoptotic cells detectable in lymphocytes cultured without any exogenous stimulus for 3 days in vitro, was evaluated. Quantitation of apoptosis was performed by staining of lymphocyte nuclei with propidium iodide and a
Beta 2-microglobulin-deficient mice demonstrate class II MHC restricted anti-viral CD4+ but not CD8+ CTL against influenza-sensitized autologous splenocytes.: Immunol Lett. 1995 May;46(1-2):67-73. Unique Identifier : AIDSLINE MED/96078156; Taylor SF; Bender BS; Department of Veterans Affairs Medical Center, University of; Florida College of Medicine, Gainesville 32608, USA.; Mice transgenic for beta 2-microglobulin gene deletion (beta 2M-/-) can clear respiratory pathogens but at a slower rate than control mice. How these mice eliminate virus is not known, but the process is believed to involve CD4+ T cells. Recent studies from other laboratories have suggested a role for CD8+ cytotoxic T
The outer surface lipoprotein A of Borrelia burgdorferi provides direct and indirect augmenting/co-stimulatory signals for the activation of CD4+ and CD8+ T cells [corrected and republished with original paging, article originally printed in Immunol Lett 1995 Feb;45(1-2):137-42]: Immunol Lett. 1995 Jun;46(3):137-42. Unique Identifier : AIDSLINE MED/96089933; Simon MM; Nerz G; Kramer MD; Hurtenbach U; Schaible UE; Wallich R; Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.
The effect of 2-acetyl-4-tetrahydroxybutylimidazole on lymphocyte subsets during a contact hypersensitivity response in the NOD mouse.: Immunol Lett. 1995 Jun;46(3):221-7. Unique Identifier : AIDSLINE MED/96089928; Gugasyan R; Losinno C; Mandel T; Walter and Eliza Hall Institute of Medical Research, Parkville,; Victoria, Australia.; The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI) is known to suppress a contact hypersensitivity (CH) response. The effect of THI on lymphocyte subsets during treatment and in a CH response has not been shown in mice. To further define the immunosuppressive potential of THI, a time-course study during the CH r
Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response.: Infect Immun. 1995 Nov;63(11):4261-7. Unique Identifier : AIDSLINE MED/96029715; Handman E; Symons FM; Baldwin TM; Curtis JM; Scheerlinck JP; Walter and Eliza Hall Institute of Medical Research, Victoria,; Australia.; Leishmania major promastigote surface antigen-2 complex (PSA-2) comprises a family of three similar but distinct polypeptides. The three PSA-2 polypeptides were purified from cultured promastigotes by a combination of detergent phase separation and monoclonal antibody affinity chromatography. Intraperitoneal vaccinati
In vitro influence of Mycoplasma penetrans on activation of peripheral T lymphocytes from healthy donors or human immunodeficiency virus-infected individuals.: Infect Immun. 1995 Nov;63(11):4277-83. Unique Identifier : AIDSLINE MED/96029717; Sasaki Y; Blanchard A; Watson HL; Garcia S; Dulioust A; Montagnier L; Gougeon ML; Departement du SIDA et des Retrovirus, Institut Pasteur, Paris,; France.; Mycoplasma penetrans is a mycoplasma species newly isolated from the urine of human immunodeficiency virus (HIV)-infected individuals and presents the only case in which an association has been found between antibodies against a mycoplasma and HIV infection. To further explore the effects of M. penetrans on the immune
Characterization of the hemolytic activity of Haemophilus ducreyi.: Infect Immun. 1995 Nov;63(11):4409-16. Unique Identifier : AIDSLINE MED/96029737; Totten PA; Norn DV; Stamm WE; Department of Medicine, University of Washington, Seattle 98104,; USA.; H. ducreyi is the causative agent of chancroid, a genital ulcer disease most prevalent in developing countries. Chancroid enhances the heterosexual transmission of human immunodeficiency virus and is identified in focal outbreaks in the United States , but little is known about its path
Demonstration of herpesvirus particles in apoptotic bodies of a brain lymphoma in an SIV-immunodeficient monkey [letter]: Int J Cancer. 1995 Nov 3;63(3):472-3. Unique Identifier : AIDSLINE MED/96071029; De Mesquita R; Biberfeld P
Human T-cell-leukemia virus type I in post-transfusional spastic paraparesis: complete proviral sequence from uncultured blood cells.: Int J Cancer. 1995 Nov 15;63(4):494-9. Unique Identifier : AIDSLINE GENBANK/L36905; Bazarbachi A; Huang M; Gessain A; Saal F; Saib A; Peries J; De The H; Galibert F; UPR43 CNRS, Retrovirus et Retrotransposons des vertebres,; Hopital Saint-Louis, Paris, France.; Human T-cell-leukemia virus type I (HTLV-I) is the causative agent of adult T-cell leukemia/lymphoma (ATL) and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). The different disease outcome may be attributable to subtle mutations leading to modification of viral tropism or infectivity. Initial atte
Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians.: Int J Cancer. 1995 Nov 15;63(4):510-5. Unique Identifier : AIDSLINE MED/96074737; Fujiyoshi T; Yashiki S; Fujiyama C; Kuwayama M; Miyashita H; Ohnishi H; Blank M; Zaninovic V; Blank A; Cartier L; et al; Department of Virology, Faculty of Medicine, Kagoshima; University, Japan.; To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-II) carriers among South American native Indians, we analyzed HLA DRB1*-DQB1* haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-c
Characteristics of EBV-infected cells in HIV-related lymphadenopathy: implications for the pathogenesis of EBV-associated and EBV-unrelated lymphomas of HIV-seropositive individuals.: Int J Cancer. 1995 Nov 27;63(5):652-9. Unique Identifier : AIDSLINE MED/96083713; Dolcetti R; Gloghini A; De Vita S; Vaccher E; De Re V; Tirelli U; Carbone A; Boiocchi M; Division of Experimental Oncology 1, INRCCS, Aviano (PN), Italy.; The present study was performed with the aim of better defining the possible role of Epstein-Barr-virus (EBV)-infected cells in the pathogenesis of HIV-related lymphadenopathy syndrome (LAS). In addition, since LAS has been considered as a pre-lymphomatous lesion, we also wished to elucidate the possible contribution
Hickman catheter-associated primary cutaneous aspergillosis in a patient with the acquired immunodeficiency syndrome.: Int J Dermatol. 1995 Aug;34(8):551-3. Unique Identifier : AIDSLINE MED/96018001; Romero LS; Hunt SJ; Division of Dermatology, University of California at San Diego; Medical Center 92103-8420, USA.
Primary localized cutaneous histoplasmosis in a patient with acquired immunodeficiency syndrome.: Int J Dermatol. 1995 Aug;34(8):558-62. Unique Identifier : AIDSLINE MED/96018004; Krunic A; Calonje E; Jeftovic D; Berger S; Milinkovic M; Lausevic Z; Martinovic N; Kokai D; Department of Dermatology, Medical School, University of; Belgrade, Yugoslavia.
[Communication barriers with the HIV+ patient perceived by health personnel]: Gac Sanit. 1995 Mar-Apr;9(47):91-100. Unique Identifier : AIDSLINE MED/96079631; Contreras Tejera A; Clavero Gonzalez G; Casas Hidalgo J; The purpose of this study was to identify major communication barriers between health professionals and patients infected with HIV. Information from 17 experts on AIDS across Spain was gathered using the Delphi technique. A total of 24 barriers were identified and compounded into gr
Effect of vitamin and trace element supplementation on immune indices in healthy elderly.: Int J Vitam Nutr Res. 1995;65(2):117-21. Unique Identifier : AIDSLINE MED/96089946; Pike J; Chandra RK; Department of Pediatrics, Memorial University of Newfoundland,; St. John's, Canada.; Aging is associated with a progressive decline in the immune system and a greater susceptibility to infection. This double-blind, placebo-controlled study, examined the effect of a vitamin and trace element supplement on immune responses of healthy, noninstitutionalized elderly subjects. Forty-seven subjects aged 61-7
Howe v. Hull.: Issues Law Med. 1995 Fall;11(2):193-5. Unique Identifier : AIDSLINE MED/96033386; Kidd TW Jr
A.D.H. v. [Alabama] State Department of Human Resources.: Issues Law Med. 1995 Fall;11(2):197-8. Unique Identifier : AIDSLINE MED/96033387; Bolde M
Viral activation from latency during retrodifferentiation of U937 cells exposed to phorbol ester followed by infection with human immunodeficiency virus type 1.: Immunopharmacology. 1995 Jun;30(1):27-39. Unique Identifier : AIDSLINE MED/96078206; Okada Y; Kimura T; Kameoka M; Kishi M; Azuma I; Ikuta K; Institute of Immunological Science, Hokkaido University, Sapporo,; Japan.; To determine the mechanism underlying the human immunodeficiency virus type 1 (HIV-1) latency and its activation in monocyte/macrophage lineage, the human promonocytic cell line U937 was infected with HIV-1 after differentiation with varied doses of phorbol 12-myristate 13-acetate (PMA). Variously differentiated inter
High susceptibility of U937-derived subclones to infection with human immunodeficiency virus type 1 is correlated with virus-induced cell differentiation and superoxide generation.: Immunopharmacology. 1995 Jun;30(1):89-101. Unique Identifier : AIDSLINE MED/96078212; Kameoka M; Kimura T; Okada Y; Nakaya T; Kishi M; Ikuta K; Institute of Immunological Science, Hokkaido University, Sapporo,; Japan.; The promonocytic human leukemic cell line U937, when infected with lymphotropic human immunodeficiency virus type 1 (HIV-1), becomes a continuous virus producer. A total of 46 U937-derived subclones in suspension was isolated and classified into three (2 high, 42 middle, and 2 low) types based on their susceptibility
[Kaposi sarcoma in Caucasian women. Clinical, chemical laboratory and endocrinologic studies in 8 women with HIV-associated or classical Kaposi sarcoma]: Hautarzt. 1995 Sep;46(9):632-7. Unique Identifier : AIDSLINE MED/96042936; Schofer H; Roder C; Zentrum der Dermatologie und Venerologie, Abteilung II, J. W.; Goethe-Universitat, Frankfurt.; Classic and HIV-associated Kaposi s sarcoma (KS) are predominantly found in male Caucasians. It is unclear why KS is so rare in women. At the Department of Dermatology, University of Frankfurt, epidemic KS was diagnosed in 299/751 (40%) male and 5/72 (18%) female HIV-infected patients. To detect common parameters rega
The diffusion of innovation in AIDS treatment: zidovudine use in two New Jersey cohorts.: Health Serv Res. 1995 Oct;30(4):593-614. Unique Identifier : AIDSLINE MED/96006240; Crystal S; Sambamoorthi U; Merzel C; Institute for Health, Health Care Policy, and Aging Research,; Rutgers University, New Brunswick, NJ 08903, USA.; OBJECTIVE. This study investigates patterns of utilization of zidovudine (ZDV) by gender, race, risk group, and other respondent characteristics following approval of this treatment. STUDY POPULATION. Longitudinal observational data were used on a demographically diverse population participating in New Jersey s Medica
Cytotoxic activity of CD4+ T cells against autologous tumor cells.: Jpn J Cancer Res. 1995 Sep;86(9):854-60. Unique Identifier : AIDSLINE MED/96042670; Konomi Y; Sekine T; Takayama T; Fuji M; Tanaka T; RI Laboratory, National Cancer Center Research Institute, Tokyo.; The 51Cr-release assay is mostly applied to detecting the cytotoxic activity of CD8+ T cells, and little is known about the activity of CD4+ T cells. Therefore, the correlation between the cytotoxic activity of CD4+ or CD8+ T cells and the incubation period with autologous tumor cells was analyzed by two methods. The
Inhibition of the association with nuclear matrix of pRB, p70 and p40 proteins along with the specific suppression of c-MYC expression by geldanamycin, an inhibitor of Src tyrosine kinase.: J Antibiot (Tokyo). 1995 Sep;48(9):1021-6. Unique Identifier : AIDSLINE MED/96049197; Yamaki H; Nakajima M; Seimiya H; Saya H; Sugita M; Tsuruo T; Institute of Molecular and Cellular Bioscience, University of; Tokyo, Japan.; Geldanamycin is an antibiotic that preferentially inhibits G1/S transition and causes G2/M arrest in human leukemia HL-60 cells. With it, we selectively inhibited recombinant Src tyrosine kinase without significantly inhibiting protein kinase A. The perturbation of cell cycling by geldanamycin was accompanied by marke
Recent advances in pediatric HIV.: J Ark Med Soc. 1995 Sep;92(4):165-8. Unique Identifier : AIDSLINE MED/96073484; Menard J; Tucker NC; Darville T; Pediatric human immunodeficiency virus (HIV) infection is a disease of mother-to-infant transmission. The World Health Organization estimates there will be ten million HIV-infected children by the end of this century. It is now thought that both intrauterine and intrapartum transmissio
The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection.: J Biol Chem. 1995 Oct 13;270(41):23883-6. Unique Identifier : AIDSLINE MED/96025754; Freed EO; Martin MA; Laboratory of Molecular Microbiology, NIAID, National Institutes; of Health, Bethesda, Maryland 20892-0460, USA.
A helical epitope in the C4 domain of HIV glycoprotein 120.: J Biol Chem. 1995 Oct 13;270(41):23918-21. Unique Identifier : AIDSLINE MED/96025763; Robey FA; Kelson-Harris T; Roller PP; Robert-Guroff M; Peptide and Immunochemistry Unit, NIDR, National Institutes of; Health, Bethesda, Maryland 20892, USA.; The fourth conserved domain of the human immunodeficiency virus type 1 (HIV-1) envelope, the C4 region of glycoprotein 120 (gp120), is an amphipathic stretch of amino acids that, based on mutational analyses, constitutes a major component of the CD4 binding region in gp120. In the absence of crystallographic and NMR d
Inefficient spliceosome assembly and abnormal branch site selection in splicing of an HIV-1 transcript in vitro.: J Biol Chem. 1995 Oct 13;270(41):24060-6. Unique Identifier : AIDSLINE MED/96025786; Dyhr-Mikkelsen H; Kjems J; Department of Molecular Biology, University of Aarhus, Denmark.; Continuous replication of human immunodeficiency virus type I (HIV-1) requires balanced expression of spliced and nonspliced mRNAs in the cytoplasm. This process is regulated post-transcriptionally by the viral-encoded Rev protein. An important prerequisite for Rev responsiveness is the presence of weak splice sites i
Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat.: J Biol Chem. 1995 Oct 27;270(43):25564-9. Unique Identifier : AIDSLINE MED/96029641; Wang L; Mukherjee S; Jia F; Narayan O; Zhao LJ; Marion Merrell Dow Foundation, Department of Microbiology,; Molecular Genetics and Immunology, University of Kansas Medical; Center, Kansas City 66160-7424, USA.; Acquired immunodeficiency syndrome (AIDS) is a result of replication of the human immunodeficiency virus type 1 (HIV-1) predominantly in CD4+ T lymphocytes and macrophages. However, most of these cells in vivo are immunologically quiescent, a condition restricting HIV-1 replication. Vpr is an HIV-1 virion protein susp
Transmission of disease through transplantation of musculoskeletal allografts.: J Bone Joint Surg Am. 1995 Nov;77(11):1742-54. Unique Identifier : AIDSLINE MED/96075603; Tomford WW; Department of Orthopaedic Surgery, Massachusetts General; Hospital, Boston 02114, USA.
An appraisal of thoracic procedures performed in patients with HIV-positive serology.: J Cardiovasc Surg (Torino). 1995 Aug;36(4):349-51. Unique Identifier : AIDSLINE MED/96069631; Canver CC; Division of Cardiothoracic Surgery, University of Wisconsin; School of Medicine, Madison 53792, USA.; Patients who have contracted the human immunodeficiency virus (HIV) often require a diagnostic or therapeutic thoracic procedure. To determine the clinical benefits of a noncardiac pulmonary intervention in the treatment of HIV-positive individuals, 82 patients with HIV-positive serology who underwent a thoracic proce
Getting human gene therapy to work.: J Cell Biochem. 1995 Aug;58(4):416-23. Unique Identifier : AIDSLINE MED/96026756; Stewart FM; University of Massachusetts Medical Center, Worcester 01655, USA.
The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein.: J Cell Sci. 1995 Aug;108 ( Pt 8):2811-23. Unique Identifier : AIDSLINE MED/96034319; Dundr M; Leno GH; Hammarskjold ML; Rekosh D; Helga-Maria C; Olson MO; Department of Biochemistry, University of Mississippi Medical; Center, Jackson 39216, USA.; The human immunodeficiency virus 1 (HIV-1) Rev transactivator protein plays a critical role in the regulation of expression of structural proteins by controlling the pathway of mRNA transport. The Rev protein is located predominantly in the nucleoli of HIV-1 infected or Rev-expressing cells. Previous studies demonstra
A holistic look at the human immunodeficiency virus pandemic.: Holist Nurs Pract. 1995 Oct;10(1):1-9. Unique Identifier : AIDSLINE MED/96037737; Gebbie KM; The worldwide event commonly referred to as the acquired immunodeficiency syndrome (AIDS) epidemic is actually a global pandemic, and one of human immunodeficiency virus infection, not just the terminal stage of that infection known as AIDS. The article identifies how a holistic perspective on the epidemic itself, on
Knowledge of human immunodeficiency virus and acquired immunodeficiency syndrome, perception of risk, and behaviors among older adults.: Holist Nurs Pract. 1995 Oct;10(1):10-7. Unique Identifier : AIDSLINE MED/96037738; Rose MA; In a study of knowledge and beliefs about human immunodeficiency virus among older persons, 458 senior center participants completed a questionnaire derived from the Health Belief Model. The older adults had a fairly good knowledge base about acquired immunodeficiency syndrome (AIDS). Although they recognized the seri
Human immunodeficiency virus seropositivity self-disclosure to sexual partners: a qualitative study.: Holist Nurs Pract. 1995 Oct;10(1):18-28. Unique Identifier : AIDSLINE MED/96037739; Sobo EJ; The article examines the process of human immunodeficiency virus seropositivity self-disclosure to sexual partners. The few studies that have been done in regard to this topic are quantitative and epidemiologic in nature and concentrate on urban gay men. In contrast, the findings described here are qualitative, and th
Long-term survivors: thriving with human immunodeficiency virus/acquired immunodeficiency syndrome.: Holist Nurs Pract. 1995 Oct;10(1):29-35. Unique Identifier : AIDSLINE MED/96037740; Strawn JM; The lack of a medical cure for human immunodeficiency virus infection and acquired immunodeficiency syndrome has resulted in growing interest in those infected individuals who seem to have longer than expected life spans, a more satisfying and sometimes improved quality of life, and in some cases no progression of imm
Social support as a stress buffer among human immunodeficiency virus-seropositive urban mothers.: Holist Nurs Pract. 1995 Oct;10(1):36-43. Unique Identifier : AIDSLINE MED/96037741; Andrews S; The article presents three examples of how mothers with human immunodeficiency virus (HIV) disease cope with stressors in their lives. These examples were generated through the clinical perspective and interpretation of one clinician-researcher. Knowledge of specific women over time indicates that HIV disease is often
Self-care activities of long-term survivors of acquired immunodeficiency syndrome.: Holist Nurs Pract. 1995 Oct;10(1):44-53. Unique Identifier : AIDSLINE MED/96037742; Barroso J; The article reports the self-care activities of long-term survivors of acquired immunodeficiency syndrome (AIDS). A naturalistic, descriptive study design using ethnographic interviewing techniques was employed to interview 14 men and 6 women who had AIDS for at least 3 years. The self-care activities reported were gl
Patient satisfaction with outpatient human immunodeficiency virus care as delivered by nurse practitioners and physicians.: Holist Nurs Pract. 1995 Oct;10(1):54-60. Unique Identifier : AIDSLINE MED/96037743; Langner SR; Hutelmyer C; Primary care of patients infected with human immunodeficiency virus (HIV) presents major challenges for the nurse practitioner. HIV disease is a chronic illness requiring frequent visits to the primary care provider and a treatment regimen that is complex and often poses difficulty in patient adherence. A patient sati
Transcending the latex barrier: the therapeutics of comfort touch in patients with acquired immunodeficiency syndrome.: Holist Nurs Pract. 1995 Oct;10(1):61-7. Unique Identifier : AIDSLINE MED/96037744; Butts JB; Janes S; Comfort touch has a positive impact on patient outcomes. When using Latex gloves, nurses often overlook the importance of skin-to-skin contact in effective comfort touch. Comfort touch is especially essential in vulnerable populations that are already experiencing several physical and emotional losses. Nurses attitud
Promoting spirituality in persons with acquired immunodeficiency syndrome: a nursing intervention.: Holist Nurs Pract. 1995 Oct;10(1):68-76. Unique Identifier : AIDSLINE MED/96037745; Peri TA; Holistic care addresses the physical, psychologic, emotional, and spiritual dimensions of the patient. The spiritual dimension, however, is frequently overlooked by health care providers. The development of spiritual well-being is crucial in helping the person with AIDS find meaning in life and death. Assessing spirit
Acquired immunodeficiency syndrome and social disease.: Holist Nurs Pract. 1995 Oct;10(1):77-89. Unique Identifier : AIDSLINE MED/96037746; Bennett JA; The social construction of disease and responses to it has implications not only for how nurses approach caregiving responsibilities but also for how we strategize for and participate in prevention efforts and elaborate priorities for advocacy. Historical review of responses to public health threats, along with critic
Epilogue: Alice in Wonderland and Through the Looking Glass.: Holist Nurs Pract. 1995 Oct;10(1):90-2. Unique Identifier : AIDSLINE MED/96037747; Kinsey KK; Gregonis SW
Characteristics of the T lymphocytes involved in experimental allergic encephalomyelitis.: J Neuroimmunol. 1995 Sep;61(2):107-16. Unique Identifier : AIDSLINE MED/96049070; Kalman B; Alder H; Lublin FD; Thomas Jefferson University, Department of Neurology,; Philadelphia, PA 19107, USA.; Both heterogeneity and restricted heterogeneity of the encephalitogenic myelin basic protein (MBP) peptide-specific T cell receptors (TCRs) were demonstrated in inbred animals depending on the strain-specific genetic characteristics, the stage of the disease, the compartment of the lymphocytes obtained and the methodo
Anti-viral and immunomodulatory effects of interferon-alpha on cultured lymphocytes from patients with human T lymphotropic virus type I-associated myelopathy (HAM/TSP).: J Neuroimmunol. 1995 Sep;61(2):213-21. Unique Identifier : AIDSLINE MED/96049081; Ijichi S; Izumo S; Nagai M; Shinmyozu K; Hall WW; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.; In contrast to therapeutic benefits of interferon-alpha (IFN-alpha) in patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), little is known about the mechanisms underlying its clinical efficacy. To investigate the anti-viral and/or immunomodulatory prop
Stimulation of alpha 1 (I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type 1 (HTLV-1) Tax gene.: J Clin Invest. 1995 Nov;96(5):2413-20. Unique Identifier : AIDSLINE MED/96066708; Munoz E; Suri D; Amini S; Khalili K; Jimenez SA; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.; The mechanisms that regulate the expression of genes encoding extracellular matrix proteins in fibroblasts and other mesenchymal cells have remained elusive. Studies from several laboratories have indicated that Tax, a trans-regulatory protein from the human T cell leukemia virus type I not only augments viral gene ex
Prurigo nodularis and photosensitivity in AIDS: treatment with thalidomide.: J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):837-8. Unique Identifier : AIDSLINE MED/96055057; Berger TG; Hoffman C; Thieberg MD; Department of Dermatology, University of California, San; Francisco, USA.
Bonsai tree: risk factor for disseminated sporotrichosis.: J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):839-40. Unique Identifier : AIDSLINE MED/96055058; Dong JA; Chren MM; Elewski BE; Case Western Reserve University, University Hospitals of; Cleveland, Department of Dermatology, OH 44106, USA.
Ultraviolet radiation therapy and HIV disease [letter; comment]: J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):841-2. Unique Identifier : AIDSLINE MED/96055059; Smith KJ; Skelton HG; Yeager J
Unusual clinical manifestation of a disfiguring necrobiotic granulomatous disease.: J Am Acad Dermatol. 1995 Nov;33(5 Pt 2):887-90. Unique Identifier : AIDSLINE MED/96055069; Willemsen M; De Coninck A; Goossens A; DeCree J; Roseeuw D; Department of Dermatology, Free University of Brussels, Belgium.; A 39-year-old woman had a disfiguring granulomatous disease of 36 years duration. Nodules appeared on her lower extremities and later extended to her face; this led to ulceration and destruction of the nasal cartilage. This disease of unknown origin does not conform to any previously described entity. Some patients w
AIDS/HIV awareness training for young people with severe learning difficulties: an evaluation of two school programmes.: J Adv Nurs. 1995 Aug;22(2):267-75. Unique Identifier : AIDSLINE MED/96000552; Newens AJ; McEwan R; Centre for Health Services Research, University of Newcastle upon; Tyne, England.; The need for sex education, counselling and HIV awareness training for young people with severe learning difficulties is discussed in relation to changes in community care over recent years. A qualitative evaluation of two sex education programmes which include HIV awareness is presented using verbatim transcripts of
Factors influencing baccalaureate nursing students' attitudes towards persons living with AIDS.: J Prof Nurs. 1995 Sep-Oct;11(5):299-305. Unique Identifier : AIDSLINE MED/96005390; Leasure R; McKenney LA; Merrill A; College of Nursing, University of Oklahoma, Oklahoma City 73190,; USA.; Using stigma theory described by Goffman (1963), a descriptive correlational study was conducted to identify factors that influence nursing students attitudes toward persons living with AIDS (PLWAs). Two hundred ten baccalaureate nursing students completed a three-part questionnaire consisting of a demographic data s
State Dental Boards' policies on a practitioner's duty to care for HIV seropositive or AIDS patients.: J Am Coll Dent. 1995 Fall;62(3):37-40. Unique Identifier : AIDSLINE MED/96045999; Friedland B; Valachovic RW; Department of Oral Medicine and Diagnostic Sciences, Harvard; School of Dental Medicine, Boston, MA 02115-5888, USA.
The impact of Magic Johnson's HIV serostatus disclosure on unmarried college students' HIV knowledge, attitudes, risk perception, and sexual behavior.: J Am Coll Health. 1995 Sep;44(2):55-8. Unique Identifier : AIDSLINE MED/96019566; Ehde DM; Holm JE; Robbins GM; Department of Rehabilitation Medicine, University of Washington; in Seattle, USA.; Unmarried heterosexual college students HIV knowledge, attitudes, risk perception, and sexual behavior were assessed before and after Magic Johnson revealed his HIV-positive serostatus. Students examined after the disclosure showed a small, though statistically significant, increase in scores on HIV knowledge. Analys
Identifying and treating HIV-related oral conditions: a clinical grand rounds approach [clinical conference]: J Am Dent Assoc. 1995 Oct;126(10):1394-400. Unique Identifier : AIDSLINE MED/96046015; Truelove EL; Chapman LI; Lalonde B; Schubert MM; Department of Oral Medicine, University of Washington School of; Dentistry, Seattle 98195, USA.; The authors describe an innovative method for teaching dental professionals to differentially diagnose and treat HIV-related oral lesions. The method included a half day of didactic presentations and a half day of clinical grand rounds. The clinical grand rounds featured clinical stations where small groups of practit
Predictive model to assess risk for cardiac allograft vasculopathy: an intravascular ultrasound study.: J Am Coll Cardiol. 1995 Nov 15;26(6):1537-44. Unique Identifier : AIDSLINE MED/96060951; Mehra MR; Ventura HO; Chambers R; Collins TJ; Ramee SR; Kates MA; Smart FW; Stapleton DD; Department of Internal Medicine, Ochsner Medical Institutions,; New Orleans, Louisiana 70121, USA.; OBJECTIVES: This study was performed to assess the influence and interdependence of immunologic and nonimmunologic risk factors in the development of cardiac allograft vasculopathy. Another primary objective was to establish a clinically useful model for risk assessment of cardiac allograft vasculopathy that would fac
Tuberculous psoas abscess.: J Emerg Med. 1995 Jul-Aug;13(4):493-8. Unique Identifier : AIDSLINE MED/96068270; Harrigan RA; Kauffman FH; Love MB; Emergency Medical Services, Temple University Hospital,; Philadelphia, PA 19140, USA.; Although its historical significance is well established, Mycobacterium tuberculosis today is considered an extremely rare cause of psoas abscess. Nontuberculous bacterial infection, most commonly secondary to an intraabdominal process but at times appearing without an identifiable source, is responsible for the vast
Appeals court upholds hospital firing of HIV-positive physician [news]: Infect Control Hosp Epidemiol. 1995 Aug;16(8):492-3. Unique Identifier : AIDSLINE MED/96015113
The gay dance party culture in Sydney: a qualitative analysis.: J Homosex. 1995;29(1):41-70. Unique Identifier : AIDSLINE MED/96025270; Lewis LA; Ross MW; National Drug and Alcohol Research Center, University of New; South Wales, Kensington, Australia.; We investigated the gay dance party phenomenon in Sydney in terms of its social and historical context by carrying out 16 qualitative interviews with patrons and organisers of these events. Sydney with a population of 3.5 million is both the capital of New South Wales and the Gay capital of
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.: J Immunol. 1995 Nov 15;155(10):4521-4. Unique Identifier : AIDSLINE MED/96062263; Khoury SJ; Akalin E; Chandraker A; Turka LA; Linsley PS; Sayegh MH; Hancock WW; Multiple Sclerosis Unit, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA 02115, USA.; We studied the contribution of the CD28-B7 costimulatory T cell activation pathway to the pathogenesis of experimental autoimmune encephalomyelitis in the Lewis rat model. Systemic administration of CTLA4Ig suppressed clinical disease and was effective even when CTLA4Ig was delayed until day 10 postimmunization, a tim
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.: J Immunol. 1995 Nov 15;155(10):4621-9. Unique Identifier : AIDSLINE MED/96062277; Marinaro M; Staats HF; Hiroi T; Jackson RJ; Coste M; Boyaka PN; Okahashi N; Yamamoto M; Kiyono H; Bluethmann H; et al; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; Despite pathophysiologic effects including diarrhea, cholera toxin (CT) is a potent mucosal immunogen and adjuvant. We investigated the influence of CT on T helper (Th)-type 1 (Th1) and Th2 cell-regulated Ag-specific B cell isotype and IgG subclass Ab responses elicited when the toxin was co-administered orally with d
Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.: J Immunol. 1995 Nov 15;155(10):4653-60. Unique Identifier : AIDSLINE MED/96062280; Moore NC; Girdlestone J; Anderson G; Owen JJ; Jenkinson EJ; Centre for Clinical Research in Immunology & Signalling, Medical; School, University of Birmingham, United Kingdom.; Positive selection triggers the differentiation of immature CD4+8+TCRlow thymocytes into TCRhigh single-positive CD4+ or CD8+ cells and is associated with major changes in gene expression. However, little is known about the DNA binding factors controlling these fundamental changes. Here we have examined NF-kappa B/Rel
Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation.: J Immunol. 1995 Nov 15;155(10):4676-84. Unique Identifier : AIDSLINE MED/96062283; Schirmbeck R; Bohm W; Melber K; Reimann J; Institute for Medical Microbiology, University of Ulm, Germany.; Many cell types efficiently present an epitope of the hepatitis B surface Ag (HBsAg) to murine class I-restricted CTL following an in vitro pulse with native 22-nm HBsAg particles. Processing of exogenous HBsAg particles required its cytochalasin B-insensitive uptake and acid proteolysis in an endocytic compartment, w
Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.: J Immunol. 1995 Nov 15;155(10):4692-701. Unique Identifier : AIDSLINE MED/96062285; Tamura T; Nakano H; Nagase H; Morokata T; Igarashi O; Oshimi Y; Miyazaki S; Nariuchi H; Department of Allergology, University of Tokyo, Japan.; In the present experiments, TCR-CD3-associated early activation signal transduction pathways were examined in Th1 and Th2 clones by the stimulation with soluble monovalent anti-CD3 which resulted in efficient production of IL-2 and IL-4 in Th1 and Th2 cells, respective
Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin.: J Immunol. 1995 Nov 15;155(10):4766-74. Unique Identifier : AIDSLINE MED/96062294; Domenech N; Henderson RA; Finn OJ; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, PA 15261, USA.; Epithelial cell mucin encoded by the MUC-1 gene is overexpressed and aberrantly glycosylated on pancreatic, breast, and ovarian cancers as well as on multiple myelomas. It is recognized by patients Ab and by T cells derived from tumor-draining lymph nodes. The T cell recognition is not MHC restricted and is specific
Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector.: J Immunol. 1995 Nov 15;155(10):4775-82. Unique Identifier : AIDSLINE MED/96062295; Frankel FR; Hegde S; Lieberman J; Paterson Y; Department of Microbiology, University of Pennsylvania, School of; Medicine, Philadelphia 19104, USA.; Cytolytic T cells, acting through cytokines or by direct lysis of infected target cells, have been shown to play a significant role in the control of viral infections and may be responsible for the prolonged asymptomatic phase following infection by HIV. Accordingly, methods that can generate strong cell-mediated immu
The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection.: J Immunol. 1995 Nov 15;155(10):4790-7. Unique Identifier : AIDSLINE MED/96062297; Huffnagle GB; Strieter RM; Standiford TJ; McDonald RA; Burdick MD; Kunkel SL; Toews GB; Internal Medicine-Pulmonary and Critical Care Medicine Division,; University of Michigan Medical Center, Ann Arbor 48109, USA.; Cryptococcus neoformans is acquired via the respiratory tract and is the leading cause of fatal mycosis in AIDS. Development of a T cell-mediated pulmonary inflammatory response is critical for clearance of this pathogen; however, the chemotactic factors that mediate inflammatory cell recruitment into the lungs have n
IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii.: J Immunol. 1995 Nov 15;155(10):4798-804. Unique Identifier : AIDSLINE MED/96062298; Kasper LH; Matsuura T; Khan IA; Department of Medicine, Dartmouth Medical School, Hanover, NH; 03755, USA.; Cytokines, in particular IFN-gamma and IL-12, are important in host protection against infection with Toxoplasma gondii. This parasite is a major cause of congenital infection and morbidity in immunosuppressed persons, especially those with AIDS. IL-7, a monomeric protein produced by bone marrow stromal cells and feta
Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs.: J Immunol. 1995 Nov 15;155(10):4844-53. Unique Identifier : AIDSLINE MED/96062303; Sabin EA; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, NY 14853, USA.; Cytokines play a major role in promoting naive Th cells to differentiate into Th1 or Th2 cells. While IL-4 is recognized as the primary pro-Th2 inducing cytokine, the identity of its cellular sources during the development of a Th2 response remains unclear. We have used Schistosoma mansoni eggs, potent stimulators of
Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-kappa B (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells.: J Immunol. 1995 Nov 15;155(10):4861-7. Unique Identifier : AIDSLINE MED/96062305; Thieblemont N; Haeffner-Cavaillon N; Haeffner A; Cholley B; Weiss L; Kazatchkine MD; INSERM U430, Broussais Hospital, Paris, France.; Monocyte/macrophages may harbor HIV in a nonproductive fashion for prolonged periods of time. Viral gene expression may be reactivated by stimulation of the cells with LPS or cytokines such as TNF-alpha in vitro. The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-bi
Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.: J Immunol. 1995 Nov 15;155(10):5011-7. Unique Identifier : AIDSLINE MED/96062324; Khoruts A; Miller SD; Jenkins MK; University of Minnesota Medical School, Department of; Microbiology, Minneapolis 55455.; We have identified a method of polarizing polyclonal populations of activated T helper cells toward either the Th1 or Th2 phenotype using different short-term in vitro culture conditions. Since the Ag used was an encephalitogenic peptide for SJL/J mice, the pathogenic potential of these cell populations was tested in
Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit.: J Immunol. 1995 Nov 15;155(10):5029-37. Unique Identifier : AIDSLINE MED/96062327; Schulze-Koops H; Lipsky PE; Kavanaugh AF; Davis LS; University of Texas Southwestern Medical Center, Harold C.; Simmons Arthritis Research Center, Department of Internal; Medicine, Dallas, TX 75235, USA.; The current studies examined whether cytokine patterns indicative of an imbalance in Th1 and Th2 cells could be identified in PBMC of patients with active rheumatoid arthritis (RA). To investigate this possibility, a reproducible PCR technique to assess cytokine mRNA levels in PBMC was employed that minimized in vitro
CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.: J Immunol. 1995 Nov 15;155(10):5046-56. Unique Identifier : AIDSLINE GENBANK/Z50839; Wang EC; Moss PA; Frodsham P; Lehner PJ; Bell JI; Borysiewicz LK; Department of Medicine, University of Wales College of Medicine,; Health Hospital, Cardiff, United Kingdom.; CD8+CD57+ lymphocytes from normal peripheral blood are divided into T cells expressing high levels of CD8 and NK cells expressing low levels of surface CD8. Increased numbers of CD8highCD57+ T cells correlate with previous exposure to human cytomegalovirus (HCMV) infection, but no
Immobilized antibodies to CD45 induce rapid morphologic changes and increased tyrosine phosphorylation of p56lck-associated proteins in T cells.: J Immunol. 1995 Dec 1;155(11):5095-103. Unique Identifier : AIDSLINE MED/96072781; Arendt CW; Hsi G; Ostergaard HL; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; CD45 is a transmembrane protein tyrosine phosphatase required for signal transduction through the Ag receptor complexes of T and B lymphocytes. Herein, we demonstrate that immobilized mAbs to the external domain of CD45 induce rapid and dramatic morphologic changes in a variety of T cell lines, including CD8+ cytotoxi
Dissociated expression of granulocyte-macrophage CSF and IL-3 in short-term T cell clones from normal mice.: J Immunol. 1995 Dec 1;155(11):5140-50. Unique Identifier : AIDSLINE MED/96072786; Fitzpatrick DR; Kelso A; Transplantation Biology Unit, Queensland Institute of Medical; Research, Australia.; Granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-3 are generally thought to be produced in a coordinated fashion by all activated T cells. We have examined this premise using quantitative kinetic analyses of the expression of GM-CSF and IL-3 in clonal cultures of mouse T cells for the first two weeks f
Mapping the Ig superantigen-binding site of HIV-1 gp120.: J Immunol. 1995 Dec 1;155(11):5151-9. Unique Identifier : AIDSLINE MED/96072787; Goodglick L; Zevit N; Neshat MS; Braun J; Department of Pathology and Laboratory Medicine, Jonsson; Comprehensive Cancer Center, UCLA School of Medicine 90095, USA.; The envelope glycoprotein, gp120, of HIV-1 has recently been identified as a member of the new family of Ig superantigens (Ig-SAg). This classification is based on the selective binding of gp120 to an unusually high proportion of endogenous, nonimmune Ig, and the selective activation of nonimmune B cells by gp120 in v
T cell-dependent loss of proliferative responsiveness to colony-stimulating factor-1 by a murine epidermal-derived dendritic cell line, XS52.: J Immunol. 1995 Dec 1;155(11):5190-7. Unique Identifier : AIDSLINE MED/96072792; Kitajima T; Ariizumi K; Bergstresser PR; Takashima A; Department of Dermatology, University of Texas Southwestern; Medical Center, Dallas 75235, USA.; We have reported previously that XS52 cells, a long-term dendritic cell (DC) line established from mouse epidermis, proliferate maximally in response to CSF-1, and that XS52 cells expanded in this manner induce brisk proliferation of HDK-1 T cells (KLH-specific Th1 clone) and 5S8 T cells (DNBS-specific Th0 clone) in t
Evidence for immunologic immaturity of cord blood T cells. Cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen.: J Immunol. 1995 Dec 1;155(11):5213-9. Unique Identifier : AIDSLINE MED/96072795; Takahashi N; Imanishi K; Nishida H; Uchiyama T; Department of Microbiology and Immunology, Tokyo Women's Medical; College, Japan.; T cell blasts resulting from stimulating human cord blood (CB) mononuclear cells (MC) and adult peripheral blood (APB) MC with a bacterial superantigen, toxic shock syndrome toxin-1 (TSST-1), and then with human rIL-2 were investigated for their reactions to restimulation with TSST-1. Expression of TCR V beta 2, which
Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.: J Immunol. 1995 Dec 1;155(11):5234-40. Unique Identifier : AIDSLINE MED/96072798; Wilkinson RW; Anderson G; Owen JJ; Jenkinson EJ; Department of Anatomy/Center for Clinical Research in Immunology; and Signaling, Medical School, University of Birmingham, United; Kingdom.; CD4+8+ cortical thymocytes are critically dependent upon interaction with the thymic epithelium to undergo positive selection and maturation into single-positive CD4+ or CD8+ cells. Here we investigate further the nature of this interaction and provide evidence that positive selection requires sustained, rather than s
Extracellular Nef protein regulates productive HIV-1 infection from latency.: J Immunol. 1995 Dec 1;155(11):5289-98. Unique Identifier : AIDSLINE MED/96072805; Fujinaga K; Zhong Q; Nakaya T; Kameoka M; Meguro T; Yamada K; Ikuta K; Section of Serology, Hokkaido University, Kita-ku, Sapporo,; Japan.; In HIV-1-infected asymptomatic carriers, the vast majority of infected cells in PBMCs are believed to be latently or nonproductively infected. We have isolated a subclone (MOLT-20-2) from an infected T cell line that expressed HIV-1 Ags at a very low level. However, viral Ag expression was markedly up-regulated by sti
Recombinant human growth-regulated oncogene-alpha induces T lymphocyte chemotaxis. A process regulated via IL-8 receptors by IFN-gamma, TNF-alpha, IL-4, IL-10, and IL-13.: J Immunol. 1995 Dec 1;155(11):5359-68. Unique Identifier : AIDSLINE MED/96072814; Jinquan T; Frydenberg J; Mukaida N; Bonde J; Larsen CG; Matsushima K; Thestrup-Pedersen K; Department of Dermatology, University of Aarhus, Denmark.; The human cytokine growth-regulated oncogene (GRO)-alpha is a small glycoprotein secreted by monocytes, endothelial cells, glycoprotein secreted by monocytes, endothelial cells, fibroblasts, synovial cells, and some tumor cells such as melanoma cells. It is structurally related to IL-8 and can activate neutrophils, wh
Peptide-induced anergy in allergen-specific human Th2 cells results in lack of cytokine production and B cell help for IgE synthesis. Reversal by IL-2, not by IL-4 or IL-13.: J Immunol. 1995 Nov 1;155(9):4199-206. Unique Identifier : AIDSLINE MED/96025875; Fasler S; Aversa G; Terr A; Thestrup-Pedersen K; de Vries JE; Yssel H; Human Immunology Department, DNAX Research Institute for; Molecular and Cellular Biology, Palo Alto, CA 94304, USA.; The induction of anergy in T cells is believed to be the result of triggering of the TCR in the absence of adequate costimulation mediated through the interaction of CD28 and its ligands, CD80 and CD86. Here, we demonstrate that stimulation of human group I allergen in Dermatophagoides pteronyssinus extract (Der p 1)-
Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.: J Immunol. 1995 Nov 1;155(9):4236-40. Unique Identifier : AIDSLINE MED/96025880; Olszowy MW; Leuchtmann PL; Veillette A; Shaw AS; Center for Immunology, Washington University School of Medicine,; St. Louis, MO 63110, USA.; The expression of the src-family kinases, p56lck and p59fyn, is critical for thymocyte development and TCR-mediated signal transduction, and may be important for signaling through other lymphoid receptors as well. Overexpression studies have demonstrated that the levels of p56lck and p59fyn expression can affect T cel
Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV).: J Immunol. 1995 Nov 1;155(9):4376-81. Unique Identifier : AIDSLINE MED/96025897; Spear GT; Lurain NS; Parker CJ; Ghassemi M; Payne GH; Saifuddin M; Department of Immunology/Microbiology, Rush Presbyterian-St.; Luke's Medical Center, Chicago, IL 60612, USA.; The current study was undertaken to determine whether the human T cell leukemia/lymphoma oncovirus type I (HTLV-I) and the herpesvirus human cytomegalovirus (HCM) incorporate host cell-derived C regulatory proteins. Our experiments showed that both CD59 and CD55 were associated wit
Soluble T cell receptors: detection and quantitative assay in fluid phase via ELISA or immuno-PCR.: J Immunol Methods. 1995 Oct 26;186(2):181-94. Unique Identifier : AIDSLINE MED/96062061; Sperl J; Paliwal V; Ramabhadran R; Nowak B; Askenase PW; Department of Medicine, Yale University School of Medicine, New; Haven, CT 06520-8013, USA.; To establish the concentration range in which soluble murine T cell receptors (sTCR), derived from the Th2 clone D10, exhibited biological activity, and to follow production and purification of D10 sTCR, we devised four quantitative immunoassays: three ELISA systems, and an immuno-PCR assay. The direct ELISA, employed
Influence of antigen presentation and exogenous cytokine activity during in vitro primary immunizations employed for the generation of monoclonal antibodies.: J Immunol Methods. 1995 Oct 26;186(2):205-16. Unique Identifier : AIDSLINE MED/96062063; Halabi G; McCullough KC; Institut fur Viruskrankheiten und Immunprophylaxe,; Mittelhausern, Switzerland.; Hybridomas secreting monoclonal antibodies (MAbs) against African horse sickness virus (AHSV) were generated using different AHSV antigen preparations (inactivated AHSV, semi-purified virus, and a preparation of nonstructural viral proteins) in one of three different in vitro primary immunization systems: (i) the Cel-
HIV-1 spreads from lymphocytes to normal human keratinocytes suitable for autologous and allogenic transplantation.: J Invest Dermatol. 1995 Nov;105(5):644-7. Unique Identifier : AIDSLINE MED/96067276; Ramarli D; Giri A; Reina S; Poffe O; Cancedda R; Varnier O; Tridente G; De Luca M; Institute of Immunology and Infectious Diseases, University of; Verona, Italy.; Normal human keratinocytes can reconstitute in vitro cohesive sheets of epithelium suitable for grafting onto patients. Despite the widespread use of autografts and allografts, no data are yet available on productive infection by human immunodeficiency virus (HIV-1) of human keratinocytes. To address this point, we ch
Human studies in the development of human immunodeficiency virus vaccines.: J Infect Dis. 1995 Nov;172(5):1175-83. Unique Identifier : AIDSLINE MED/96036371; Dolin R; University of Rochester School of Medicine and Dentistry, New; York, USA.; The safety and immunogenicity of candidate human immunodeficiency virus type 1 (HIV-1) vaccines have been studied in > 1500 healthy, seronegative (HIV-1-uninfected) subjects. HIV-1 envelope proteins, gp160 and gp120, have been the most extensively investigated. A live virus vector construct, vaccinia with insertion of
CD4+ lymphocytes in perinatal human immunodeficiency virus (HIV) infection: evidence for pregnancy-induced immune depression in uninfected and HIV-infected women.: J Infect Dis. 1995 Nov;172(5):1221-7. Unique Identifier : AIDSLINE MED/96036377; Rich KC; Siegel JN; Jennings C; Rydman RJ; Landay AL; Department of Pediatrics, University of Illinois at Chicago; 60612, USA.; Immune function changes during pregnancy and human immunodeficiency virus (HIV) infection. T helper function and phenotypes in HIV-infected and -uninfected pregnant and postpartum women and nonpregnant uninfected control women were studied. T helper function was assessed by interleukin-2 (
Reduced capacity of antibodies from patients infected with human immunodeficiency virus type 1 (HIV-1) group O to neutralize primary isolates of HIV-1 group M viruses.: J Infect Dis. 1995 Nov;172(5):1228-37. Unique Identifier : AIDSLINE MED/96036378; Nyambi PN; Nkengasong J; Peeters M; Simon F; Eberle J; Janssens W; Fransen K; Willems B; Vereecken K; Heyndrickx L; et al; Institute of Tropical Medicine, Antwerp, Belgium.; Neutralizing antibody patterns in sera of persons infected with human immunodeficiency virus type 1 (HIV-1) groups M and O to their homologous and heterologous primary isolates were determined in a peripheral blood mononuclear cell-based neutralization assay and correlated with their ability to bind to V3 loop synthet
Weak binding of VX-478 to human plasma proteins and implications for anti-human immunodeficiency virus therapy.: J Infect Dis. 1995 Nov;172(5):1238-45. Unique Identifier : AIDSLINE MED/96036379; Livington DJ; Pazhanisamy S; Porter DJ; Partaledis JA; Tung RD; Painter GR; Vertex Pharmaceuticals Inc., Cambridge, MA 02139, USA.; VX-478 is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki, 0.6 nM) and of HIV-1 replication in antiviral assays (IC90, 80 nM). The fractional binding of VX-478 to human plasma and to purified plasma proteins was determined by equilibrium dialysis and difference UV spectrophotometry. Bind
A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team.: J Infect Dis. 1995 Nov;172(5):1246-52. Unique Identifier : AIDSLINE MED/96036380; Haubrich RH; Flexner C; Lederman MM; Hirsch M; Pettinelli CP; Ginsberg R; Lietman P; Hamzeh FM; Spector SA; Richman DD; Department of Medicine, University of California, San Diego.; Ro 24-7429, a Tat antagonist, dosed at 75, 150, or 300 mg/day, was compared with nucleoside analogue (zidovudine or didanosine) for 12 weeks in 96 human immunodeficiency virus (HIV)-infected patients to assess safety and activity. The primary adverse effect of Ro 24-7429 was rash, which necessitated treatment disconti
Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody responses to pneumococcal vaccine.: J Infect Dis. 1995 Nov;172(5):1253-60. Unique Identifier : AIDSLINE MED/96036381; Mascart-Lemone F; Gerard M; Libin M; Crusiaux A; Franchioly P; Lambrechts A; Goldman M; Clumeck N; Department of Immunology, Hopital Erasme, Brussels, Belgium.; The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide vaccine were analyzed in 35 asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-infected patients stratified according to their CD4 cell counts and in 12 healthy controls. Both the antibody titers in serum and saliva and the numb
Constitutive expression of major histocompatibility complex class II antigens on monocytes and B cells correlates with disease in simian immunodeficiency virus-infected rhesus macaques.: J Infect Dis. 1995 Nov;172(5):1261-7. Unique Identifier : AIDSLINE MED/96036382; Ashworth LA; Hall GA; Sharpe SA; Dennis MJ; Thornton C; Cook RW; Smith H; Cranage MP; Centre for Applied Microbiology and Research, Salisbury, United; Kingdom.; Constitutive host factors that influence progression to AIDS are understood poorly. In the macaque model for AIDS, 35 animals infected with simian immunodeficiency virus (SIV) were analyzed for major histocompatibility complex class II antigen expression on blood monocytes and B cells by immunostaining and flow cytome
Identification of virulence-associated antigens and plasmids in Rhodococcus equi from patients with AIDS.: J Infect Dis. 1995 Nov;172(5):1306-11. Unique Identifier : AIDSLINE MED/96036388; Takai S; Imai Y; Fukunaga N; Uchida Y; Kamisawa K; Sasaki Y; Tsubaki S; Sekizaki T; Department of Animal Hygiene, School of Veterinary Medicine and; Animal Sciences, Kitasato University, Towada, Japan.; Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. However, little is known about the characteristics of R. equi isolates from humans. This study characterized the plasmid content, expression of a virulence-associated antigen, and mouse virulence of 19 R. equi iso
Prolonged shedding of amantadine-resistant influenzae A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis.: J Infect Dis. 1995 Nov;172(5):1352-5. Unique Identifier : AIDSLINE MED/96036396; Klimov AI; Rocha E; Hayden FG; Shult PA; Roumillat LF; Cox NJ; Influenza Branch, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Consecutive A (H3N2) influenza virus isolates from 2 influenza virus-infected immunodeficient patients treated with amantadine were examined using a novel polymerase chain reaction (PCR)-restriction analysis for resistance to this antiviral compound. The data indicate that immunodeficient patients may shed resistant v
Genital ulcers associated with human immunodeficiency virus-related immunosuppression in female sex workers in Abidjan, Ivory Coast.: J Infect Dis. 1995 Nov;172(5):1371-4. Unique Identifier : AIDSLINE MED/96036401; Ghys PD; Diallo MO; Ettiegne-Traore V; Yeboue KM; Gnaore E; Lorougnon F; Kale K; Van Dyck E; Brettegaard K; Hoyi YM; et al; Project RETRO-CI, Bureau Central de Coordination du Comite; National de Lutte Contre le SIDA, Abidjan, Ivory Coast.; A cross-sectional study among female sex workers in Abidjan was conducted to study the association between sexually transmitted diseases and human immunodeficiency virus (HIV) infection and HIV-related immunosuppression. Among 1209 women tested for HIV, 962 (80%) were seropositive. HIV infection was independently asso
Quantitative measures of human immunodeficiency virus-specific antibodies predict progression to AIDS.: J Infect Dis. 1995 Nov;172(5):1375-9. Unique Identifier : AIDSLINE MED/96036402; Strathdee SA; Frank JW; McLaughlin J; Leblanc M; Major C; O'Shaughnessy MV; Read SE; British Columbia Centre for Excellence in HIV/AIDS, Vancouver,; Canada.; Studies examining specific antibodies directed against antigenic components of human immunodeficiency virus (HIV), as potential markers of progression to AIDS, have reported inconsistent results. We used reflectance densitometry and survival analysis to determine whether single quantitative measures of HIV-specific an
A pilot study to evaluate the development of resistance to nevirapine in asymptomatic human immunodeficiency virus-infected patients with CD4 cell counts of > 500/mm3: AIDS Clinical Trials Group Protocol 208.: J Infect Dis. 1995 Nov;172(5):1379-83. Unique Identifier : AIDSLINE MED/96036403; Havlir D; McLaughlin MM; Richman DD; Department of Medicine, University of California, San Diego, La; Jolla, USA.; Treatment of human immunodeficiency virus (HIV) infection with nevirapine in patients with
Primary structure of the V3 region of gp120 from sequential human immunodeficiency virus type 1 isolates obtained from patients from the time of seroconversion.: J Infect Dis. 1995 Nov;172(5):1384-7. Unique Identifier : AIDSLINE GENBANK/U17480; Distler O; McQueen PW; Tsang ML; Evans LA; Hurren L; Byrne C; Penny R; Cooper DA; Delaney SF; Department of Biotechnology, University of New South Wales,; Australia.; V3 loop sequences were compared from 5 human immunodeficiency virus type 1 (HIV-1)-infected patients over time. Three patients remained asymptomatic and 2 became symptomatic with large decrease in CD4 cell counts. The patient isolates were previously evaluated for phenotypic and antigenic properties and had different
Mother-to-child transmission of human immunodeficiency virus type 1 in Nairobi [letter; comment]: J Infect Dis. 1995 Nov;172(5):1418-9. Unique Identifier : AIDSLINE MED/96036413; Dunn D; Newell ML
The false-positive polymerase chain reaction and the ostrich [letter; comment]: J Infect Dis. 1995 Nov;172(5):1420-1. Unique Identifier : AIDSLINE MED/96036414; Jehuda-Cohen T
Excess intrauterine fetal demise associated with maternal human immunodeficiency virus infection.: J Infect Dis. 1995 Dec;172(6):1451-60. Unique Identifier : AIDSLINE MED/96083487; Langston C; Lewis DE; Hammill HA; Popek EJ; Kozinetz CA; Kline MW; Hanson IC; Shearer WT; Department of Pathology, Baylor College of Medicine, Houston, TX; 77030, USA.; A prospective study of transplacental transmission of human immunodeficiency virus (HIV) showed an increased rate of spontaneous fetal demise in HIV-seropositive mothers: 14 losses in 124 pregnancies. HIV was detected in placental and fetal tissues in 7 of 14 by in situ hybridization. The proportion of fetal infection
Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency.: J Infect Dis. 1995 Dec;172(6):1461-8. Unique Identifier : AIDSLINE MED/96083488; Nduati RW; John GC; Richardson BA; Overbaugh J; Welch M; Ndinya-Achola J; Moses S; Holmes K; Onyango F; Kreiss JK; Department of Pediatrics, University of Nairobi, Kenya.; Breast milk samples from human immunodeficiency virus type 1 (HIV-1)-seropositive women were analyzed by polymerase chain reaction to determine the prevalence and determinants of HIV-1-infected cells in breast milk. Breast milk samples (212) were collected from 107 women, and 58% of the samples had detectable HIV-1 DN
Human immunodeficiency virus DNA in urethral secretions in men: association with gonococcal urethritis and CD4 cell depletion.: J Infect Dis. 1995 Dec;172(6):1469-74. Unique Identifier : AIDSLINE MED/96083489; Moss GB; Overbaugh J; Welch M; Reilly M; Bwayo J; Plummer FA; Ndinya-Achola JO; Malisa MA; Kreiss JK; Department of Medicine, University of Washington, Seattle, USA.; To evaluate the prevalence and correlates of human immunodeficiency virus (HIV)-infected cells in urethral secretions, samples were collected from 106 HIV-seropositive men with and without urethritis. HIV DNA was detected by polymerase chain reaction in 27% of 184 urethral specimens and was associated with CD4 cell de
Phase I evaluation of zalcitabine administered to human immunodeficiency virus-infected children.: J Infect Dis. 1995 Dec;172(6):1475-9. Unique Identifier : AIDSLINE MED/96083490; Chadwick EG; Nazareno LA; Nieuwenhuis TJ; Massarella JW; de Dennis SR; Williams K; Yogev R; Department of Pediatrics, Northwestern University Medical School,; Chicago, Illinois, USA.; The safety, tolerability, and pharmacokinetics of zalcitabine ( ddC ) in a single oral dose (0.02 mg/kg) was evaluated in 23 mildly symptomatic human immunodeficiency virus-infected children (mean age, 4.2 years). After administration of ddC, blood samp
Development of zidovudine resistance mutations in patients receiving prolonged didanosine monotherapy.: J Infect Dis. 1995 Dec;172(6):1480-5. Unique Identifier : AIDSLINE MED/96083491; Demeter LM; Nawaz T; Morse G; Dolin R; Dexter A; Gerondelis P; Reichman RC; Department of Medicine (Infectious Diseases Unit), University of; Rochester School of Medicine and Dentistry, New York 14642, USA.; Human immunodeficiency virus type 1 (HIV-1) isolates from 2 patients who received didanosine (ddI) monotherapy for > 2 years were analyzed for reverse transcriptase (RT) mutations by sequencing of proviral DNA from peripheral blood mononuclear cell cultures. One patient was otherwise antiretroviral-naive; the other ha
Incidence and predictors of human immunodeficiency virus type 1 seroconversion in patients attending sexually transmitted disease clinics in India.: J Infect Dis. 1995 Dec;172(6):1486-91. Unique Identifier : AIDSLINE MED/96083492; Mehendale SM; Rodrigues JJ; Brookmeyer RS; Gangakhedkar RR; Divekar AD; Gokhale MR; Risbud AR; Paranjape RS; Shepherd ME; Rompalo AE; et al; National AIDS Research Institute, B. J. Medical College, Pune,; India.; The first estimates of the seroincidence of human immunodeficiency virus type 1 (HIV-1) and of the risk factors for seroconversion in a cohort of high-risk patients attending sexually transmitted disease (STD) clinics in India are reported. Between 1993 and 1995, 851 HIV-1-seronegat
N-acetylcysteine enhances antibody-dependent cellular cytotoxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients.: J Infect Dis. 1995 Dec;172(6):1492-502. Unique Identifier : AIDSLINE MED/96083493; Roberts RL; Aroda VR; Ank BJ; Department of Pediatrics, University of California, Los Angeles,; USA.; Patients with AIDS have decreased levels of the intracellular antioxidant, glutathione, in their circulating lymphocytes and plasma. N-acetylcysteine (NAC) increases intracellular stores of glutathione and has direct antioxidant properties. In this study, the effects of glutathione and NAC on the cytotoxicity of neutr
Coinfection of hepatitis C virus with human immunodeficiency virus and progression to AIDS. Italian Seroconversion Study.: J Infect Dis. 1995 Dec;172(6):1503-8. Unique Identifier : AIDSLINE MED/96083494; Dorrucci M; Pezzotti P; Phillips AN; Lepri AC; Rezza G; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Rome, Italy.; To assess the influence of hepatitis C virus (HCV) on the natural history of human immunodeficiency virus (HIV) infection, a longitudinal study was conducted among 416 HIV-positive, AIDS-free persons infected through injecting drug use or homosexual or heterosexual activity and with known seroconversion dates. End poi
High prevalence of human T cell lymphotropic virus type II infection in patients affected by human immunodeficiency virus type 1--associated predominantly sensory polyneuropathy.: J Infect Dis. 1995 Dec;172(6):1595-8. Unique Identifier : AIDSLINE MED/96083509; Zehender G; De Maddalena C; Osio M; Cavalli B; Parravicini C; Moroni M; Galli M; Clinica delle Malattie Infettive, University of Milan, Italy.; The etiopathogenesis of peripheral neuropathy (PN) that frequently affects human immunodeficiency virus (HIV) type 1-positive patients remains undefined. Forty-seven HIV-1-positive patients with PN (8 with inflammatory demyelinating polyneuropathy and 39 with predomin
Interaction with human immunodeficiency virus type 1 modulates innate effector functions of human monocytes.: J Infect Dis. 1995 Dec;172(6):1598-601. Unique Identifier : AIDSLINE MED/96083510; Zerlauth G; Maier E; Chehadeh H; Zimmermann K; Eibl MM; Mannhalter JW; Immuno AG, University of Vienna, Austria.; The effect of human immunodeficiency virus (HIV) type 1 on human mononuclear phagocyte effector functions in response to infection with bacteria of the Mycobacterium avium-intracellular complex (MAC) was investigated. The results showed that interaction of HIV-1 or its constituents with CD4 expressed in the monocyte m
Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.: J Infect Dis. 1995 Dec;172(6):1605-7. Unique Identifier : AIDSLINE MED/96083512; de Lellis L; Fabris M; Cassai E; Corallini A; Giraldo G; Feo C; Monini P; Institute of Microbiology, University of Ferrara, Italy.; The pathogenesis of Kaposi s sarcoma (KS) is suggested to be related to an infectious agent transmitted by sexual contact. Recently, DNA sequences homologous to gamma herpesviridae have been identified in AIDS-associated KS, but no information is available concerning non-AIDS-associated KS. Five classic, 12 endemic, a
Diagnosis of Pneumocystis carinii pneumonia in AIDS patients by using polymerase chain reactions on serum specimens.: J Infect Dis. 1995 Dec;172(6):1623-6. Unique Identifier : AIDSLINE MED/96083517; Atzori C; Lu JJ; Jiang B; Bartlett MS; Orlando G; Queener SF; Smith JW; Cargnel A; Lee CH; II Divisione Malattie Infettive, Ospedale L. Sacco, Milan, Italy.; A polymerase chain reaction (PCR) that amplifies the internal transcribed spacers of rRNA genes of Pneumocystis carinii (Pc-ITS-PCR) was compared with dihydrofolate reductase (DHFR) gene PCR to determine its usefulness in the diagnosis of Pneumocystis carinii pneumonia. All specimens from non-P. carinii pneumonia AIDS
Human immunodeficiency virus type 1 candidate vaccine breakthrough infection [letter; comment]: J Infect Dis. 1995 Dec;172(6):1636-8. Unique Identifier : AIDSLINE MED/96083521; Mascola JR; McNeil JG
[Study on reverse transcriptase inhibiting antibody in plasma of HIV-1 seropositive subjects]: Kansenshogaku Zasshi. 1995 Aug;69(8):851-7. Unique Identifier : AIDSLINE MED/96083295; Saito T; Suzuki K; Ito A; Hayashi T; Watanabe S; Kondo M; Imai M; Department of Virology, Kanagawa Prefectural Public Health; Laboratories.; Reverse transcriptase (RT) inhibiting antibody in a series of plasma of HIV-1-seropositive subjects was quantitatively measured by poly A-linked colorimetric microtiter plate assay. The plasma were obtained from 6 asymptomatic carrier (AC)s and from 3 patients who progressed to AIDS. They had been followed 29-51 month
[Studies on maternal transmission of HIV-1]: Kansenshogaku Zasshi. 1995 Aug;69(8):858-63. Unique Identifier : AIDSLINE MED/96083296; Tabei Y; Sadamasu K; Mori K; Monma K; Sekine H; Kudoh Y; Miyazawa Y; Okada K; Department of Microbiology, Tokyo Metropolitan Research; Laboratory of Public Health.; To investigate HIV-1 transmission from mother to child, samples taken from 3 HIV-1 sero-positive pregnant mothers, 3 children born by caesareans from their mothers and therapeutic abortion from 2 HIV-1 sero-positive mothers were tested for HIV-1 antibody by westernblot, p24 antigen by antigen captured ELISA, proviral
[A case of AIDS patient who was hard to diagnose from an initial symptom of interstitial pneumonitis]: Kansenshogaku Zasshi. 1995 Sep;69(9):1007-11. Unique Identifier : AIDSLINE MED/96056830; Hakoda S; Higashimoto K; Kiuchi S; Kitazawa Y; Yonezu S; Fujita Y; Okamura A; Tanaka T; Emergency and Critical Care Center, Kansai Medical University.; A thirty-six year old male was admitted to the hospital because of fever and dyspnea. On the eighth day the patient turned out to be HIV positive. Although aggressive therapy was performed, the patient died of HIV related disease such as Pneumocystis carinii pneumonitis and
[Prior enrichment of HIV-DNA with probe-DNA particles for an efficient PCR diagnosis]: Kansenshogaku Zasshi. 1995 Sep;69(9):957-62. Unique Identifier : AIDSLINE MED/96056823; Fan K; Tano H; Kitajima M; Tamatsukuri S; Furuichi Y; Hayashi T; Imai M; Japan Synthetic Rubber Co., Ltd. Tsukuba Research Laboratory.; PCR mediated detection of HIV-DNA has been widely used. However, compared with traditional immunological diagnoses, the extraction of DNA is a laborious and time consuming step. We have developed a procedure for the efficient isolation and concentration of HIV-DNA from cell lysates. We report here a novel method by on
[The viewpoints of viral vertical transmission from fetal neonatal immunologic aspects]: Nippon Sanka Fujinka Gakkai Zasshi. 1995 Aug;47(8):713-23. Unique Identifier : AIDSLINE MED/96063377; Ichijo M; Department of Obstetrics and Gynecology, Nara Medical University.; A. The development of fetal Immune system 1. Complement: Alternative pathway is dominant in the development of fetal complement. 2. Neutrophil function: Phagocytosis in full term infants was increased to be adult-level, but bactericidal function was decreased. 3. NK activity: NK activity in full-term infants was signi
Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma.: Int J Radiat Biol. 1995 Oct;68(4):411-2. Unique Identifier : AIDSLINE MED/96071036; Formenti SC; Chak L; Gill P; Buess EM; Hill CK; Department of Radiation Oncology, University of Southern; California School of Medicine, Los Angeles 90033, USA.; Fibroblasts cultured from skin biopsies of patients with AIDS and Kaposi s sarcoma were found to be more radiosensitive than fibroblasts from non-HIV-infected-sources. This supports clinical observations of overt sensitivity to radiotherapy in some AIDS patients with Kaposi s sarcoma.
Experimental hypersensitivity pneumonitis: in vitro effects of interleukin-2 and interferon-gamma.: J Lab Clin Med. 1995 Nov;126(5):485-94. Unique Identifier : AIDSLINE MED/96074348; Fei R; Gott K; Edwards B; Schuyler M; Department of Medicine, Albuquerque Veterans Administration; Medical Center, NM 87108, USA.; Cultured CD4+ cells are responsible for transfer of adoptive murine experimental hypersensitivity pneumonitis (EHP) (ARRD 1992; 146:1582-8). To characterize interactions that occur in vitro that result in cells able to transfer EHP, we added either antibody to IFN-gamma, antibody to
On the road to recovery for emotional harm. Is the fear of AIDS a legally compensable injury?: J Leg Med. 1995 Sep;16(3):417-45. Unique Identifier : AIDSLINE MED/96005379; Bollinger RC; Southern Illinois University School of Law, Law Journal Office,; Carbondale, IL 62901, USA.
Alveolar macrophages as a cell source of cytokine hyperproduction in HIV-related interstitial lung disease.: J Leukoc Biol. 1995 Nov;58(5):495-500. Unique Identifier : AIDSLINE MED/96071069; Agostini C; Sancetta R; Cerutti A; Semenzato G; Department of Clinical Medicine, 1st Medical Clinic, Padua; University School of Medicine, Italy.; Pulmonary macrophages play an important role in the pathogenesis of the acquired immunodeficiency syndrome (AIDS). They are known to be discrete target cells for human immunodeficiency virus (HIV), and compelling evidence is accumulating that alveolar macrophages (AMs) from HIV-infected patients behave as versatile se
Antibodies to interleukin 12 abrogate established experimental colitis in mice.: J Exp Med. 1995 Nov 1;182(5):1281-90. Unique Identifier : AIDSLINE MED/96042126; Neurath MF; Fuss I; Kelsall BL; Stuber E; Strober W; Mucosal Immunity Section, National Institutes of Health/National; Institute of Allergy and Infectious Diseases/LCI, Bethesda,; Maryland 20892-1890, USA.; In this study, we describe a novel murine model of chronic intestinal inflammation induced by the hapten reagent 2,4,6-trinitrobenzene sulfonic acid (TNBS). Rectal application of low doses of TNBS in BALB/c and SJL/J mice resulted in a chronic transmural colitis with severe diarrhea, weight loss, and rectal prolapse,
Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.: J Exp Med. 1995 Nov 1;182(5):1357-67. Unique Identifier : AIDSLINE MED/96042133; Openshaw P; Murphy EE; Hosken NA; Maino V; Davis K; Murphy K; O'Garra A; DNAX Research Institute, Palo Alto, California 94304-1104, USA.; CD4+ T helper (Th) cells can be classified into different types based on their cytokine profile. Cells with these polarized patterns of cytokine production have been termed Th1 and Th2, and can be distinguished functionally by the production of IFN-gamma and IL-4, respectively. These phenotypes are crucial in determin
Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.: J Exp Med. 1995 Nov 1;182(5):1505-15. Unique Identifier : AIDSLINE MED/96042147; Sad S; Mosmann TR; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; Naive T cells in the periphery mainly secrete interleukin (IL) 2 upon activation. After stimulation in the presence of appropriate costimulators, both CD4+ and CD8+ T cells differentiate into effector cells secreting distinct T helper (Th) 1- and Th2-like cytokine patterns. Subsequent to differentiation, both CD4+ (Th
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.: J Exp Med. 1995 Nov 1;182(5):1527-36. Unique Identifier : AIDSLINE MED/96042149; Gavett SH; O'Hearn DJ; Li X; Huang SK; Finkelman FD; Wills-Karp M; Department of Environmental Health Sciences, Johns Hopkins; University, Baltimore, Maryland 21205, USA.; Allergic asthma is characterized by airway hyperresponsiveness and pulmonary eosinophilia, and may be mediated by T helper (Th) lymphocytes expressing a Th2 cytokine pattern. Interleukin (IL) 12 suppresses the expression of Th2 cytokines and their associated responses, including eosinophilia, serum immunoglobulin E, a
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.: J Exp Med. 1995 Nov 1;182(5):1579-84. Unique Identifier : AIDSLINE MED/96042155; Hosken NA; Shibuya K; Heath AW; Murphy KM; O'Garra A; Department of Immunology, DNAX Research Institute, Palo Alto,; California 94304, USA.; The dose of foreign antigen can influence whether a cell-mediated or humoral class of immune response is elicited, and this may be largely accounted for by the development of CD4+ T helper cells (Th) producing distinct sets of cytokines. The ability of antigen dose to direct the development of a Th1 or Th2 phenotype f
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.: J Exp Med. 1995 Nov 1;182(5):1591-6. Unique Identifier : AIDSLINE MED/96042157; Constant S; Pfeiffer C; Woodard A; Pasqualini T; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut, USA.; Naive CD4+ T cells can differentiate into cells predominantly involved in humoral immunity, known as T helper type 2 cells (Th2), or cells involved in cell-mediated immunity, known as Th1 cells. In this report, we show that priming of CD4+ T cells bearing a transgene-encoded T cell receptor can lead to differentiation
AIDS and suicide.: J Fam Pract. 1995 Nov;41(5):493-6. Unique Identifier : AIDSLINE MED/96067268; Kirchner JT; Department of Family and Community Medicine, Lancaster General; Hospital, Pennsylvania, USA.; An association between suicide and the acquired immune deficiency syndrome (AIDS) has been noted in several epidemiologic studies. Numerous case reports also support the trend of an increased suicide risk in persons infected with human immunodeficiency virus (HIV) and persons with AIDS. A variety of medical, neurologi
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodies.: J Gen Virol. 1995 Oct;76 ( Pt 10):2457-66. Unique Identifier : AIDSLINE MED/96030855; Tanchou V; Delaunay T; Bodeus M; Roques B; Darlix JL; Benarous R; Signalisation, Inflammation et Transformation Cellulaire, U332; INSERM, Paris, France.; The nucleocapsid protein NCp15 of human immunodeficiency virus type 1 (HIV-1) is a small basic protein with two zinc fingers. It is required for virion morphogenesis and synthesis of proviral DNA. As the first step in our study of the structural domains involved in the various functions of this protein, 18 monoclonal
Infection of Macaca nemestrina brain with human immunodeficiency virus type 1.: J Gen Virol. 1995 Oct;76 ( Pt 10):2467-76. Unique Identifier : AIDSLINE GENBANK/K03455; Frumkin LR; Patterson BK; Leverenz JB; Agy MB; Wolinsky SM; Morton WR; Corey L; Department of Medicine, University of Washington School of; Medicine, Seattle 98195, USA.; We previously reported that pigtailed macaques (Macaca nemestrina) became infected after intravenous inoculation with the LAI strain of human immunodeficiency virus type 1 (HIV-1), an isolate that replicates in both M. nemestrina lymphocytes and blood-derived monocyte/macrophages. In the current study we investigated
Possible involvement of cell fusion and viral recombination in generation of human immunodeficiency virus variants that display dual resistance to AZT and 3TC.: J Gen Virol. 1995 Oct;76 ( Pt 10):2601-5. Unique Identifier : AIDSLINE MED/96030871; Gu Z; Gao Q; Faust EA; Wainberg MA; Lady Davis Institute, Jewish General Hospital, McGill University,; Montreal, Quebec, Canada.; We have attempted to relate genetic recombination involving human immunodeficiency virus type 1 (HIV-1) to multiple drug resistance by using PEG to fuse subclones of U937 cells that carried HIV-1 recombinants resistant to either 3 -azido-3 -deoxythymidine (
Efficient replication of human immunodeficiency virus type 1 and measles virus in a human-to-mouse graft versus host disease model permits immunization research.: J Gen Virol. 1995 Nov;76 ( Pt 11):2707-15. Unique Identifier : AIDSLINE MED/96068803; Huppes W; Tenner-Racz K; Kraal G; Health Research-TNO, HV Rijswijk, The Netherlands.; An acute graft versus host disease (GvHD) murine model was developed to study the pathogenic and protective mechanisms against viruses that replicate in cells of the human immune system. The model allowed efficient replication of lymphotropic, macrophage and amphitropic strains of human immunodeficiency virus type 1 (
Function of human immunodeficiency virus type 1 Vpu protein in various cell types.: J Gen Virol. 1995 Nov;76 ( Pt 11):2717-22. Unique Identifier : AIDSLINE MED/96068804; Sakai H; Tokunaga K; Kawamura M; Adachi A; Institute for Virus Research, Kyoto University, Japan.; We evaluated the function of human immunodeficiency virus type 1 vpu gene in various cell lines. We established a highly sensitive system consisting of chloramphenicol acetyltransferase and reverse transcriptase assays and used it to monitor the effects of mutation of the vpu gene. In some cell lines, Vpu protein was
Early replication block of human immunodeficiency virus type 1 in monkey cells.: J Gen Virol. 1995 Nov;76 ( Pt 11):2723-30. Unique Identifier : AIDSLINE MED/96068805; Shibata R; Sakai H; Kawamura M; Tokunaga K; Adachi A; Department of Viral Oncology, Kyoto University, Japan.; The genetic and functional basis of the replication-defective nature of human immunodeficiency virus type 1 (HIV-1) in monkey cells was studied. By the generation and characterization of chimeras between HIV-1 and simian immunodeficiency virus, the sequence encompassing the 3 half of the long terminal repeat, gag and
Detection of HCV RNA in serum and seminal fluid from HIV-1 co-infected intravenous drug addicts.: J Med Virol. 1995 Aug;46(4):364-7. Unique Identifier : AIDSLINE MED/96061542; Fiore RJ; Potenza D; Monno L; Appice A; DiStefano M; Giannelli A; LaGrasta L; Romanelli C; DiBari C; Pastore G; Clinic of Infectious Diseases, University of Bari, Italy.; The presence of hepatitis C virus (HCV) RNA in serum and seminal fluid was investigated in eleven drug addicts coinfected with HIV-1 and HCV. Serum and seminal fluid were taken from each patient at the same time point. HCV RNA was found in ten of the eleven serum samples tested, but only in one of the semen samples. N
HTLV tax-rex DNA and antibodies in idiopathic amyotrophic lateral sclerosis.: J Neurol Sci. 1995 May;129 Suppl:140-4. Unique Identifier : AIDSLINE MED/96059168; Ferrante P; Westarp ME; Mancuso R; Puricelli S; Westarp MP; Mini M; Caputo D; Zuffolato MR; Institute of Medical Microbiology, University of Milan, Italy.; In an attempt to verify the possible role of retrovirus in idiopathic amyotrophic lateral sclerosis (ALS), the sera of 21 ALS patients admitted to the Neurological Unit of the Don Gnocchi Foundation in Milan, Italy , and of 9 ALS patients from Ulm University in
Sporadic ALS/MND: a global neurodegeneration with retroviral involvement?: J Neurol Sci. 1995 May;129 Suppl:145-7. Unique Identifier : AIDSLINE MED/96059169; Westarp ME; Ferrante P; Perron H; Bartmann P; Kornhuber HH; Department of Neurology, University of Ulm, Germany.; Sporadic amyotrophic lateral sclerosis may be an aetiologically heterogenous disease. We confirmed elevated circulating IgG immune complexes, and altered IgG seroreactivities against human retroviral antigens (HIV-2 and HTLV immunoblots) in overlapping subgroups of patients. Together with preliminary findings of a pos
Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men.: J Clin Oncol. 1995 Oct;13(10):2540-6. Unique Identifier : AIDSLINE MED/96007578; Lyter DW; Bryant J; Thackeray R; Rinaldo CR; Kingsley LA; Department of Medicine, Graduate School of Public Health,; University of Pittsburgh, PA, USA.; PURPOSE: To determine if the rates of malignancies other than Kaposi s sarcoma (KS) and non-Hodgkin s lymphoma (NHL) are increased in human immunodeficiency virus (HIV)-infected homosexual men. SUBJECTS AND METHODS: From 1984 through 1993, 1,199 homosexual men were studied in the P
Coherent view of non-Hodgkin's lymphoma.: J Clin Oncol. 1995 Oct;13(10):2656-75. Unique Identifier : AIDSLINE MED/96007593; Aisenberg AC; Hematology/Oncology Unit, Massachusetts General Hospital, Boston; 02114, USA.; PURPOSE: Even though non-Hodgkin s lymphoma is already sixth in incidence and mortality among malignant neoplasms (and the incidence was increasing at a rate of 3% to 4% per year before the advent of AIDS epidemic-associated lymphomas), most physicians and many oncologists find the
Human immunodeficiency virus-associated neoplasia: changing spectrum? [editorial]: J Clin Oncol. 1995 Nov;13(11):2684-7. Unique Identifier : AIDSLINE MED/96067224; Kaplan LD
Testicular germ cell tumors and human immunodeficiency virus infection: a report of 26 cases. Italian Cooperative Group on AIDS and Tumors.: J Clin Oncol. 1995 Nov;13(11):2705-11. Unique Identifier : AIDSLINE MED/96067227; Bernardi D; Salvioni R; Vaccher E; Repetto L; Piersantelli N; Marini B; Talamini R; Tirelli U; Division of Medical Oncology and AIDS, Centro di Riferimento; Oncologico, Aviano, Italy.; PURPOSE: Besides tumors that are diagnostic of AIDS, such as non-Hodgkin s lymphoma , Kaposi s sarcoma, and invasive carcinoma of the cervix, other tumors have been described in the human immunodeficiency virus (HIV) setting. Some case reports on testicular cancer in HIV-infected pa
Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte.: J Neurosci. 1995 Nov;15(11):7712-26. Unique Identifier : AIDSLINE MED/96066793; Giulian D; Li J; Bartel S; Broker J; Li X; Kirkpatrick JB; Department of Neurology, Baylor Center for AIDS Research, Baylor; College of Medicine, Houston, Texas 77030, USA.; To investigate differences among brain-derived microglia and other classes of immune cells, we compared the morphologies and growth properties of mononuclear phagocytes isolated from tissues of the newborn rat. Scanning EM shows that microglia from postnatal rat brain are covered with spines (typically > 20 per cell b
[Introduction: the status and perspective of human immunodeficiency virus infection and its neurologic consequences]: J Neuroradiol. 1995 Sep;22(3):133-5. Unique Identifier : AIDSLINE MED/96043305; Cordoliani YS; Hopital d'instruction des armees du Val-de-Grace, Paris.
[The epidemiology and cost of AIDS in France]: J Neuroradiol. 1995 Sep;22(3):136-41. Unique Identifier : AIDSLINE MED/96043306; Trotot PM; Lamoureux P; Pialoux G; Institut Pasteur, Radiodiagnostic, Paris.; Throughout the world the AIDS epidemic continues and even seems to accelerate in regions previously thought to be untouched. The number of cases has increased by 60% in one year. With its 15,000 seropositive persons and 35,000 cases of declared AIDS, France is the most affected of
[Clinical and paraclinical diagnosis of AIDS neurologic lesions]: J Neuroradiol. 1995 Sep;22(3):142-7. Unique Identifier : AIDSLINE MED/96043307; Bossi P; Astagneau P; Bricaire F; Service de maladies infectieuses, parasitaires et tropicales,; Groupe hospitalier Pitie-Salpetriere, Paris.; Seventy to eighty percent of HIV-infected patients exhibit neurological disorders at an advanced stage of the disease. In almost 90% of cases anatomical examination of brains shows histological lesions. Even when often reversible neurological disorders occur during the HIV primary infection, most of the manifestations
[Early cerebral lesions in HIV infection. Postmortem radio-pathologic correlations in non-AIDS asymptomatic seropositive patients]: J Neuroradiol. 1995 Sep;22(3):148-60. Unique Identifier : AIDSLINE MED/96043308; Hassine D; Gray F; Chekroun R; Chretien F; Marc B; Durigon M; Schouman-Claeys E; Service de Radiologie, Hopital Raymond Poincare, Faculte de; Medecine, Paris-Ouest, Garches.; In order to evaluate the diagnostic and prognostic value of MRI in the very early stages of HIV infection, we have compared the results of postmortem brain MRI and neuropathological studies in 7 asymptomatic HIV seropositive individuals, 8 seronegative controls with similar cause of death and 6 patients who died of AI
[HIV and dementia: neuropathology]: J Neuroradiol. 1995 Sep;22(3):161-2. Unique Identifier : AIDSLINE MED/96043309; Seilhean D; Duyckaerts C; Hauw JJ; Laboratoire de Neuropathologie R. Escourolle, Hopital de la; Salpetriere, Paris.; Cognitive disorders associated with HIV infection may be due to focal lesions (lymphoma, toxoplasmosis, progressive multifocal leukoencephalitis, etc.), metabolic encephalopathy (e.g. hepatic insufficiency) or psychiatric disorders (depression). In the absence of such causes a cognitive and motor syndrome associated w
[Imagery of human immunodeficiency virus (HIV) encephalitis]: J Neuroradiol. 1995 Sep;22(3):163-8. Unique Identifier : AIDSLINE MED/96043310; Brugieres P; Combes C; Ricolfi F; Houhou S; Sadik JC; Thomas P; Gray F; Gaston A; Services de Neuroradiologie, de l'Hopital Henri Mondor,; Creteil.; The authors present the different aspects of HIV encephalitis in CT and MR in a series of 15 patients with anatomopathological proof. Atrophy was the most commonly found lesion (12 patients) and could rapidly be evolutive. White matter lesions (9 patients) were more of ten nodular than diffuse. They were better demons
[AIDS dementia. Prognosis and therapeutic perspectives]: J Neuroradiol. 1995 Sep;22(3):169-71. Unique Identifier : AIDSLINE MED/96043311; Lubetzki C; Inserm U-134, Hopital de la Salpetriere, Paris.; AIDS dementia complex is a severe complication related to HIV infection of the central nervous system. It has been estimated to affect about 7% of AIDS patients, with an increased frequency in very young and old patients. In most cases, it appears in severely immuno-deficient patie
[MRI aspects of progressive multifocal leukoencephalopathy]: J Neuroradiol. 1995 Sep;22(3):172-9. Unique Identifier : AIDSLINE MED/96043312; Sarrazin JL; Soulie D; Derosier C; Lescop J; Schill H; Cordoliani YS; H.I.A du Val-de-Grace, Paris.; Progressive Multifocal Leukoencephalopathy is a demyelinating disease. MRI shows high signal intensity areas on T2w sequence and low intensity aeras on T1w sequence, without enhancement after intravenous contrast injection. The involvement of arcuate fiber (U fibers) creates a sharp border with the cortex. There is no
[Pathologic anatomy of cytomegalovirus encephalomyelitis and varicella-zona virus encephalomyelitis]: J Neuroradiol. 1995 Sep;22(3):180-3. Unique Identifier : AIDSLINE MED/96043313; Henin D; Gervaz E; Seilhean D; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Beaujon, Clichy.; Cytomegalovirus ( CMV ) infection of the nervous system is frequent in acquired immunodeficiency syndrome (AIDS) and can be responsible for encephalitis, encephalomyelitis, meningoradiculitis or polyradiculo-neuropathy. Encephalitis is characterized at microscopy
[CMV and VZV encephalitis in AIDS]: J Neuroradiol. 1995 Sep;22(3):184-92. Unique Identifier : AIDSLINE MED/96043314; Hassine D; Gray F; Chekroun R; De Truchis P; Schouman-Claeys E; Vallee C; Service de Radiologie, Hopital Raymond Poincare, Garches.; MATERIAL AND METHODS: Eighty patients were followed up prospectively. Histological correlation was obtained in 25 cases. All MRI examinations were performed on at 0.5 Tesla in T1-weighted sequences with and without gadolinium injection, and in axial or frontal T2-weighted spin echo sequences. Histological confirmation
[The impact of the prevention of cerebral toxoplasmosis]: J Neuroradiol. 1995 Sep;22(3):193-5. Unique Identifier : AIDSLINE MED/96043315; Katlama C; Departement des Maladies Infectieuses, Hopital; Pitie-Salpetriere, Paris.; In France , where 70% of adults are latently infected by toxoplasma, from 20% to 40% of patients with AIDS developed toxoplasmic encephalitis until recently. The prophylactic use of drugs which are active against pneumocystis and toxoplasma has proven to be efficient. These drugs ar
[Cerebral toxoplasmosis. Neuroradiologic diagnosis and prognostic monitoring]: J Neuroradiol. 1995 Sep;22(3):196-203. Unique Identifier : AIDSLINE MED/96043316; Martin-Duverneuil N; Cordoliani YS; Sola-Martinez MT; Miaux Y; Weill A; Chiras J; Neuroradiologie Charcot, Hopital de la Salpetriere, Paris.; Cerebral toxoplasmosis remains the most frequent etiology of cerebral masses in AIDS. In most cases, the disclosure of multiple enhanced masses is suggestive of diagnosis of toxoplasmosis and leads to undertake presumptive therapy. Sometimes, the pattern is less suggestive, and the possibility of primary cerebral lymp
[The epidemiology of cerebral lymphoma in AIDS]: J Neuroradiol. 1995 Sep;22(3):204-6. Unique Identifier : AIDSLINE MED/96043317; Mikol J; Costagliola D; Polivka M; Thiebaut JB; Trotot P; Service Central d'Anatomie Pathologique, Hopital Lariboisiere,; Paris.; Cerebral lymphomas are one of the complications of AIDS. Their increasing frequency, especially in the last decade, has to be correlated with the incidence of systemic lymphomas and especially central nervous system (CNS) lymphomas in non immuno-compromised patients. CNS involvement is found in 40% of systemic lymphom
[The diagnosis of primary cerebral lymphoma in AIDS. The contribution of imaging]: J Neuroradiol. 1995 Sep;22(3):207-17. Unique Identifier : AIDSLINE MED/96043318; Laissy JP; Lebtahi R; Cordoliani YS; Henry-Feugeas MC; Schouman-Claeys E; Services de Radiologie, Hopital Bichat, Paris.; Apart from the very frequent HIV encephalitis, which lays the foundation for opportunistic infections, the most common diseases encountered in HIV-infected patients are toxoplasmosis and lymphoma; the percentage of cases of other diseases is very small. It is capital to diagnose cerebral lymphoma at an early stage in
[Cerebral lesions in AIDS: what can be expected from scintigraphy? Cerebral tomographic scintigraphy using thallium-201: a contribution to the differential diagnosis of lymphomas and infectious lesions]: J Neuroradiol. 1995 Sep;22(3):218-28. Unique Identifier : AIDSLINE MED/96043319; Berry I; Gaillard JF; Guo Z; Cordoliani YS; Massip P; Manelfe C; Danet B; Service de Biophysique et Medecine Nucleaire, CHU Rangueil,; Toulouse.; CT and MRI are not consistently able to differentiate central nervous system (CNS) lymphoma from focal cerebral infection such as toxoplasmosis in the human immunodeficiency virus (HIV) involvement. In this study thallium 201 (and/or technetium-MIBI) SPECT was performed in 6 patients suffering from AIDS and CNS lesion
Balancing judicial interests in HIV cases. Part 1, Issues for nurse administrators.: J Nurs Adm. 1995 Oct;25(10):51-5. Unique Identifier : AIDSLINE MED/96027901; Zachary MK; School of Business, West Georgia College, Carrollton, USA.; Legal issues involving the human immunodeficiency virus are consuming an increasing amount of the attention of hospital and nurse administrators. When the legal interests of patients, staff, and administrators conflict, healthcare administrators must determine which interest should prevail. Recently, two courts have d
Balancing judicial interests in HIV cases: Part 2, Issues for nurse administrators.: J Nurs Adm. 1995 Nov;25(11):9-14. Unique Identifier : AIDSLINE MED/96069660; Zachary MK; Business Administration, West Georgia College, Carrolton, USA.; Legal issues involving human immunodeficiency virus are consuming an increasing amount of the attention of hospitals and nurse administrators. At times, the legal interests of patients, staff, and administrators conflict, and it is the duty of healthcare administrators to determine which interests should prevail. Rece
Predicting cutaneous hypersensitivity reactions to cotrimoxazole in HIV-infected individuals receiving primary Pneumocystis carinii pneumonia prophylaxis.: J Gen Intern Med. 1995 Jul;10(7):380-6. Unique Identifier : AIDSLINE MED/96066065; Hennessy S; Strom BL; Berlin JA; Brennan PJ; Center for Clinical Epidemiology and Biostatistics, University of; Pennsylvania School of Medicine, Philadelphia 19104-6095, USA.; OBJECTIVES: To measure the incidence of cutaneous hypersensitivity reactions to cotrimoxazole in the setting of primary Pneumocystis carinii pneumonia (PCP) prophylaxis: to measure the incidence of severe reactions: and to identify predictors for these outcomes. DESIGN: Retrospective cohort study. SETTING: One univers
Ability of primary care physicians to diagnose and manage Pneumocystis carinii pneumonia.: J Gen Intern Med. 1995 Jul;10(7):395-9. Unique Identifier : AIDSLINE MED/96066068; Curtis JR; Paauw DS; Wenrich MD; Carline JD; Ramsey PG; Department of Medicine, University of Washington, Seattle, 98195,; USA.; This study assesses the ability of primary care physicians to diagnose and manage Pneumocystis carinii pneumonia (PCP) in a standardized patient (SP) with unidentified HIV infection. One hundred thirty-four primary care physicians from five Northwest states saw an SP with unidentified HIV infection who presented with
Alcohol consumption among HIV-infected patients.: J Gen Intern Med. 1995 Aug;10(8):458-60. Unique Identifier : AIDSLINE MED/96037350; Lefevre F; O'Leary B; Moran M; Mossar M; Yarnold PR; Martin GJ; Glassroth J; Division of General Internal Medicine, Northwestern University; Medical School, Chicago, Illinois 60611, USA.; This prospective, cohort study analyzed the prevalence of alcoholism and patterns of alcohol intake over time in a cohort of HIV-infected patients, predominantly homosexual/bisexual men. One hundred eleven HIV-positive subjects were recruited from a comprehensive HIV clinic associated with a large Midwestern universit
Health insurance and utilization in Pneumocystis carinii pneumonia.: J Gen Intern Med. 1995 Aug;10(8):461-3. Unique Identifier : AIDSLINE MED/96037351; Loue S; Slymen DJ; Morgenstern H; Whalen C; Department of Medicine, University of California, Los Angeles,; USA.; To examine the relationship between health insurance status and health services utilization among HIV-infected patients with active Pneumocystis carinii pneumonia (PCP), the discharge and outpatient databases of a large California medical facility were reviewed. Four hundred fifty records met the inclusion criteria. L
The changing spectrum of pulmonary infections due to nontuberculous mycobacteria.: J Okla State Med Assoc. 1995 Sep;88(9):373-82. Unique Identifier : AIDSLINE MED/96033393; Boggs DS; University of Oklahoma Health Sciences Center, Division of; Pulmonary and Critical Care Medicine, Oklahoma City, USA.; Although nontuberculous mycobacteria (NTM) infections are not common, there is evidence that they are becoming increasingly recognized and in some parts of the country occur more frequently than M. tuberculosis. The classic description of NTM pulmonary infection is that of a male patient with cavitary infiltrates and
Informal caregivers of persons with AIDS [letter]: J Palliat Care. 1995 Autumn;11(3):53. Unique Identifier : AIDSLINE MED/96045989; Clipp EC
Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking.: J Pharmacokinet Biopharm. 1994 Dec;22(6):469-80. Unique Identifier : AIDSLINE MED/96015276; Milad MA; Ludwig EA; Anne S; Middleton E Jr; Jusko WJ; Department of Pharmaceutics, School of Pharmacy, State University; of New York at Buffalo 14260, USA.; The circadian pattern of the immune system correlates with that of circulating T-helper cells and inversely with cortisol concentrations. Corticosteroids, both endogenous and exogenous, cause lymphocyte dimunition in blood by retention of cells in the lymphatic circulation. A physiologic pharmacodynamic model was deve
Opportunistic infections in HIV seropositive individuals.: J R Coll Physicians Lond. 1995 Jul-Aug;29(4):335-9. Unique Identifier : AIDSLINE MED/96003078; Gazzard BG; Chelsea & Westminster Hospital, London.
[Spinal cord toxoplasmosis and AIDS]: J Radiol. 1995 Jul;76(7):453-5. Unique Identifier : AIDSLINE MED/96011912; Carteret M; Petit E; Granat O; Marichez M; Gilquin J; Service de Radiologie, Hopital Saint-Joseph, Paris.; Toxoplasmosis is the most common brain parasitic infection in acquired immunodeficiency syndrome (AIDS). Spinal cord localisations are still rare (2 cases with cerebral involvement, 2 cases without). A case of both spinal cord and cerebral involvement is reported. MR imaging was performed because of sensory level (L1)
Total number of immunocompetent cells in the normal rat epididymis and after vasectomy.: J Reprod Fertil. 1995 Jul;104(2):193-8. Unique Identifier : AIDSLINE MED/96046541; Hooper P; Smythe E; Richards RC; Howard CV; Lynch RV; Lewis-Jones DI; Department of Human Anatomy and Cell Biology, University of; Liverpool, UK.; The aim of this study was to make unbiased quantitative estimates of the number of T8 cytotoxic cells and T4 helper cells and macrophages in the head and tail of rat epididymides, using newly developed design-based stereological methods in fertile control animals, and to compare these with results from vasectomized an
Expression of endogenous HIV-1 crossreactive antigens within normal human extravillous trophoblast cells.: J Reprod Immunol. 1995 Mar;28(3):233-45. Unique Identifier : AIDSLINE MED/96070219; Lyden TW; Johnson PM; Mwenda JM; Rote NS; Department of Microbiology/Immunology, Wright State University; School of Medicine, Dayton, Ohio 45435, USA.; Expression of intact endogenous retroviruses by normal placental villous trophoblast and immuno-crossreactivity of villous trophoblast with anti-retroviral antisera have been documented. The nature and/or potential function of these particles/proteins has not yet been fully defined. We previously reported that monoclo
AIDS' nomenclature's spelling or style [letter]: J R Soc Health. 1995 Oct;115(5):331. Unique Identifier : AIDSLINE MED/96054644; Rafiquzzman M
Hydroxylated aromatic inhibitors of HIV-1 integrase.: J Med Chem. 1995 Oct 13;38(21):4171-8. Unique Identifier : AIDSLINE MED/96028186; Burke TR Jr; Fesen MR; Mazumder A; Wang J; Carothers AM; Grunberger D; Driscoll J; Kohn K; Pommier Y; Laboratories of Medicinal Chemistry and Molecular Pharmacology,; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Efficient replication of HIV-1 requires integration of a DNA copy of the viral genome into a chromosome of the host cell. Integration is catalyzed by the viral integrase, and we have previously reported that phenolic moieties in compounds such as flavones, caffeic acid phenethyl ester (CAPE, 2), and curcumin confer in
Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure.: J Med Chem. 1995 Oct 27;38(22):4463-73. Unique Identifier : AIDSLINE MED/96071095; Romines KR; Watenpaugh KD; Howe WJ; Tomich PK; Lovasz KD; Morris JK; Janakiraman MN; Lynn JC; Horng MM; Chong KT; et al; Structural, Analytical, and Medicinal Chemistry Research, Upjohn; Laboratories, Kalamazoo, Michigan 49001, USA.; Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivatives of 1 with enhanced enzyme inhibitory activity. The first st
Design, synthesis, and structure-activity relationship of novel dinucleotide analogs as agents against herpes and human immunodeficiency viruses.: J Med Chem. 1995 Nov 10;38(23):4648-59. Unique Identifier : AIDSLINE MED/96068833; Hakimelahi GH; Moosavi-Movahedi AA; Sadeghi MM; Tsay SC; Hwu JR; Organosilicon and Synthesis Laboratory, Institute of Chemistry,; Academia Sinica, Nankang, Taipei, Taiwan, Republic of China.; A new acyclic nucleoside phosphonate (13) containing an adenine moiety was synthesized, which acted as an excellent inhibitor of calf mucosal adenosine deaminase. This inhibitory property allows it to exert great synergistic effect on certain antiviral agents (e.g., ara-A, 37). Phosphonate 13 was not phosphorylated by
A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.: J Med Chem. 1995 Nov 10;38(23):4679-86. Unique Identifier : AIDSLINE MED/96068836; Dolle V; Fan E; Nguyen CH; Aubertin AM; Kirn A; Andreola ML; Jamieson G; Tarrago-Litvak L; Bisagni E; URA 1387 CNRS, Synthese Organique, Institut Curie, Section de; Recherche, Orsay, France.; 4-(Arylthio)-pyridin-2(1H)-ones variously substituted in their 3-, 5-, and 6-positions have been synthesized as a new series of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-pyridinone hybrid molecules. Biological studies revealed that some of them show potent HIV-1 specific reverse transcriptase inhibitory
Nucleotide changes in oxidatively stressed lymphocytes.: J Biochem Toxicol. 1995 Jun;10(3):137-42. Unique Identifier : AIDSLINE MED/96073320; Palace GP; Lawrence DA; Department of Pharmacology and Toxicology, Albany Medical; College, NY 12208, USA.; Similar to HIV-1-induced suppression of thymus-derived lymphocytes (T cells), oxidatively stressed T cells show inhibited DNA synthesis and proliferation. The influence of oxidative stress on nucleotide pools was explored using 3H-uridine addition to OKT3-stimulated peripheral blood lymphocytes. The cells were preincu
Candida albicans isolates from HIV-infected and AIDS patients exhibit enhanced adherence to epithelial cells.: J Med Microbiol. 1995 Dec;43(6):452-7. Unique Identifier : AIDSLINE MED/96080238; Sweet SP; Cookson S; Challacombe SJ; Department of Oral Medicine and Pathology, UMDS Guy's Hospital,; London.; The increased prevalence of oral candidosis associated with HIV infection must be intrinsically related to immunological changes in the host, but might also involve alterations to the infecting strains of yeast. This study aimed to determine if strains of Candida albicans isolated from asymptomatic HIV-infected indivi
AIDS is a multifactorial neuroimmunoendocrine disorder due to energy crisis in the 'Milieu Interieur' [letter]: J Natl Med Assoc. 1995 Oct;87(10):729, 731. Unique Identifier : AIDSLINE MED/96061847; Spartalis MA
Hypercalcemia associated with adult T-cell leukemia/lymphoma (ATL).: J Natl Med Assoc. 1995 Oct;87(10):746-8. Unique Identifier : AIDSLINE MED/96061851; Peter SA; Cervantes JF; Department of Medicine, St Mary's Hospital of Brooklyn, NY 11213,; USA.; Hypercalcemia is a frequent manifestation of human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma (ATL). Human T-cell lymphotrophic virus type I infection is endemic in the Caribbean, Japan , Melanesia, and Africa. This article presents two cases
End-stage renal disease in patients infected with human immunodeficiency virus: a retrospective review of 38 cases.: J Natl Med Assoc. 1995 Oct;87(10):762-5. Unique Identifier : AIDSLINE MED/96061856; Obayomi OO; Dillard MG; Hosten AO; Cruz IA; Department of Medicine, Howard University College of Medicine,; Washington, DC 20060, USA.; A retrospective review was conducted to evaluate the influence of risk factors for human immunodeficiency virus (HIV) infection on the outcome of patients with end-stage renal disease (ESRD). The records of all patients seen at Howard University Hospital between February 1984 and July 1994 with a diagnosis of HIV infe
Seroprevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and rapid plasma reagin in a trauma population.: J Trauma. 1995 Sep;39(3):533-7; discussion 537-8. Unique Identifier : AIDSLINE MED/96022090; Caplan ES; Preas MA; Kerns T; Soderstrom C; Bosse M; Bansal J; Constantine NT; Hendrix E; Caplan M; Department of Infectious Diseases, R Adams Cowley Shock Trauma; Center, School of Medicine, University of Maryland Medical; Center, Baltimore 21201-1595, USA.; We evaluated the presence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and rapid plasma reagin (RPR) among patients admitted to our trauma unit from April 15 to June 30, 1993. Of 984 patients tested, we found 255 (26%) had evidence of exposure to one or more of these agents:
Acupuncture for the treatment of cocaine addiction. Investigation of a needle puncture control.: J Subst Abuse Treat. 1995 May-Jun;12(3):195-205. Unique Identifier : AIDSLINE MED/96030114; Avants SK; Margolin A; Chang P; Kosten TR; Birch S; Yale University School of Medicine, CMHC/Substance Abuse Center,; New Haven, CT 06519, USA.; We conducted a 6-week, single-blind study of acupuncture for cocaine dependence in methadone-maintained patients (N = 40) for the purpose of identifying an appropriate needle puncture control for use in future large-scale clinical trials. Patients were randomly assigned to receive daily acupuncture in three auricular
Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.: J Virol. 1995 Nov;69(11):6609-17. Unique Identifier : AIDSLINE MED/96013752; Trkola A; Pomales AB; Yuan H; Korber B; Maddon PJ; Allaway GP; Katinger H; Barbas CF 3rd; Burton DR; Ho DD; et al; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; We have tested three human monoclonal antibodies (MAbs) IgG1b12, 2G12, and 2F5) to the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1), and a tetrameric CD4-IgG molecule (CD4-IgG2), for the ability to neutralize primary HIV-1 isolates from the genetic clades A through F and from group O. Each of
A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: recovery of an anti-HIV mouse/human pseudotype retrovirus.: J Virol. 1995 Nov;69(11):6618-26. Unique Identifier : AIDSLINE MED/96013753; Federico M; Nappi F; Ferrari G; Chelucci C; Mavilio F; Verani P; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The expression of a human immunodeficiency virus (HIV) type 1 provirus (F12-HIV) cloned from a nonproducer, chronically infected CD4 down-regulated Hut-78 cell clone (F12) does not lead to the formation of viral particles and, upon transfection in HeLa CD4+ cells, confers resistance to HIV superinfection without affec
Interactions of the transcription factor AP-1 with the long terminal repeat of different human immunodeficiency virus type 1 strains in Jurkat, glial, and neuronal cells.: J Virol. 1995 Nov;69(11):6634-42. Unique Identifier : AIDSLINE MED/96013755; Canonne-Hergaux F; Aunis D; Schaeffer E; Unite INSERM 338, Centre de Neurochimie, Strasbourg, France.; Human immunodeficiency virus type 1 (HIV-1) infection of the neuronal and astroglial cells of the central nervous system has been proposed to contribute to HIV-1-associated dementia . Recently it was shown that differences in the nucleotide sequence of the long terminal repeat (LTR)
Mucosal model of immunization against human immunodeficiency virus type 1 with a chimeric influenza virus.: J Virol. 1995 Nov;69(11):6678-86. Unique Identifier : AIDSLINE GENBANK/U26830; Muster T; Ferko B; Klima A; Purtscher M; Trkola A; Schulz P; Grassauer A; Engelhardt OG; Garcia-Sastre A; Palese P; et al; Institut fur Angewandte Mikrobiologie, Universitat fur; Bodenkultur, Vienna, Austria.; Previously, we constructed a chimeric influenza virus that expresses the highly conserved amino acid sequence ELDKWA of gp41 of human immunodeficiency virus type 1 (HIV-1). Antisera elicited in mice by infection with this chimeric virus showed neutralizing activity against distantly related HIV-1 isolates (T. Muster,
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.: J Virol. 1995 Nov;69(11):6687-96. Unique Identifier : AIDSLINE MED/96013761; Masuda T; Planelles V; Krogstad P; Chen IS; Department of Microbiology & Immunology, UCLA School of Medicine; 90095, USA.; Retroviral integration is the step which leads to establishment of the provirus, cis- and trans-acting regions of the human immunodeficiency type 1 (HIV-1) retrovirus genome, including the attachment site (att) at the ends of the unintegrated viral DNA and the conserved domains within the integrase (IN) protein, have
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.: J Virol. 1995 Nov;69(11):6705-11. Unique Identifier : AIDSLINE MED/96013763; He J; Choe S; Walker R; Di Marzio P; Morgan DO; Landau NR; Aaron Diamond AIDS Research Center, New York, New York 10016,; USA.; The Vpr accessory gene product of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus is believed to play a role in permitting entry of the viral core into the nucleus of nondividing cells. A second role for Vpr was recently suggested by Rogel et al. (M. E. Rogel, L. I. Wu, and M. Emerman, J.
The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis.: J Virol. 1995 Nov;69(11):6720-8. Unique Identifier : AIDSLINE MED/96013765; Henke A; Huber S; Stelzner A; Whitton JL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; Coxsackievirus infections have previously been shown to cause acute or chronic myocarditis in humans, and several mouse models have been established to study the pathology of this disease. Myocardial injury may result from direct viral effects and/or may be immune mediated. To determine the relative roles of these pro
A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes.: J Virol. 1995 Nov;69(11):6735-41. Unique Identifier : AIDSLINE GENBANK/D45226; Kondo T; Uenishi H; Shimizu T; Hirama T; Iwashiro M; Kuribayashi K; Tamamura H; Fujii N; Fujisawa R; Miyazawa M; et al; Department of Biophysics, Faculty of Science, Kyoto University,; Japan.; Several dominant T-cell receptors of cytotoxic T-lymphocyte (CTL) clones specific for FBL-3 tumor antigen were clonally amplified in mixed lymphocyte tumor cell cultures derived from an individual immune mouse. Every CTL clone analyzed had a common specificity for a single epitope in the precursor to cell membrane-ass
Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.: J Virol. 1995 Nov;69(11):6758-69. Unique Identifier : AIDSLINE MED/96013770; Michael NL; Chang G; d'Arcy LA; Tseng CJ; Birx DL; Sheppard HW; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; We have studied the sequence and function of the human immunodeficiency virus type 1 (HIV-1) nef genes from nine patients with highly divergent rates of disease progression enrolled in a longitudinal study of HIV disease. Over an average of 7.8 years of follow-up, three patients had net positive changes in CD4+ T-cell
Neuronal expression of human immunodeficiency virus type 1 env proteins in transgenic mice: distribution in the central nervous system and pathological alterations.: J Virol. 1995 Nov;69(11):6770-8. Unique Identifier : AIDSLINE MED/96013771; Berrada F; Ma D; Michaud J; Doucet G; Giroux L; Kessous-Elbaz A; Department of Pathology, Faculty of Medicine, University of; Montreal, Quebec, Canada.; It is now well documented that human immunodeficiency virus type 1 (HIV-1) induces encephalopathy in patients with AIDS. In vitro studies have implicated the envelope protein (gp120) as a factor which causes neuronal death. To better evaluate the role and elucidate the mechanisms of gp120 neurotoxicity, we have develo
Negative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP-binding motif of the AAV Rep68 protein.: J Virol. 1995 Nov;69(11):6787-96. Unique Identifier : AIDSLINE MED/96013773; Kyostio SR; Wonderling RS; Owens RA; Laboratory of Molecular and Cellular Biology, National Institute; of Diabetes and Digestive and Kidney Diseases, National; Institutes of Health, Bethesda, MD 20892-0840, USA.; Transcript levels from the P5 promoter of adeno-associated virus type 2 (AAV) are negatively regulated by the AAV Rep78 and Rep68 proteins in the absence of helper virus. We have identified a Rep-responsive negative cis element of the P5 promoter between the P5 TATA box and transcription start site by using 5 and 3
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease.: J Virol. 1995 Nov;69(11):6810-8. Unique Identifier : AIDSLINE MED/96013776; Huang M; Orenstein JM; Martin MA; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460,; USA.; The human immunodeficiency virus type 1 (HIV-1) Gag protein precursor, Pr55Gag, contains at its C-terminal end a proline-rich, 6-kDa domain designated p6. Two functions have been proposed for p6: incorporation of the HIV-1 accessory protein Vpr into virus particles and virus particle production. To characterize the ro
Immunogenic determinants of a neuropathogenic murine leukemia virus.: J Virol. 1995 Nov;69(11):6847-51. Unique Identifier : AIDSLINE MED/96013781; Robbins DS; Remington MP; Sarzotti M; St. Louis D; Hoffman PM; Research Service, Department of Veterans Affairs Medical Center,; Baltimore, Maryland 21201, USA.; Previous studies of Cas-Br-M murine leukemia virus (MuLV) (Cas-MuLV) infection demonstrated that cytotoxic T cells (CTL) of the CD8+ phenotype play a role in resistance to the neuropathogenic effects of the virus in NFS/N mice. In the current study, we sought to identify the Cas-MuLV epitopes that are immunogenic for
Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.: J Virol. 1995 Nov;69(11):6852-8. Unique Identifier : AIDSLINE MED/96013782; Black AC; Luo J; Watanabe C; Chun S; Bakker A; Fraser JK; Morgan JP; Rosenblatt JD; Division of Hematology/Oncology, University of California, Los; Angeles 90095-1678, USA.; Efficient expression of human T-cell leukemia virus (HTLV) and human immunodeficiency virus structural proteins requires Rx and Rev proteins, respectively. Decreased expression of Gag and Env appears to be due, in part, to intragenic RNA sequences, termed cis-acting repressive sequences (CRS), and may be mediated by b
Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.: J Virol. 1995 Nov;69(11):6859-64. Unique Identifier : AIDSLINE MED/96013783; Re F; Braaten D; Franke EK; Luban J; Department of Microbiology, Columbia University College of; Physicians and Surgeons, New York, New YOrk 10032, USA.; Human immunodeficiency virus type 1 (HIV-1) vpr inhibits the replication of tumor cell lines and peripheral blood mononuclear cells. Here it is demonstrated that expression of vpr, either in the context of a provirus or from an independent genetic element, induces a discrete cell cycle arrest, with cells containing 4N
A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles.: J Virol. 1995 Nov;69(11):6873-9. Unique Identifier : AIDSLINE MED/96013785; Lu YL; Bennett RP; Wills JW; Gorelick R; Ratner L; Department of Medicine, Washington University, St. Louis,; Missouri 63110, USA.; Incorporation of Vpr into human immunodeficiency virus type 1 (HIV-1) virions is mediated by the Gag protein, independently of other viral components. We have coexpressed Vpr and Gag constructs in a vaccinia virus expression system in order to map the region of Gag involved in Vpr packaging. Deletion of the carboxyl-t
Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4.: J Virol. 1995 Nov;69(11):6898-903. Unique Identifier : AIDSLINE MED/96013789; Benkirane M; Hirn M; Carriere D; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, Centre; National de la Recherche Scientifique UPR 9008-Institut National; de la Sante et de la Recherche Medicale U249, Montpellier,; France.; We recently demonstrated that monoclonal antibody (MAb) 13B8-2, specific for the immunoglobulin (Ig) complementary determining region 3 (CDR3)-like region of the CD4 molecule, inhibits viral transcription in human immunodeficiency virus (HIV)-infected CEM cells and HIV type 1 (HIV-1) promoter activity. Here, we have s
The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4.: J Virol. 1995 Nov;69(11):6904-10. Unique Identifier : AIDSLINE MED/96013790; Benkirane M; Schmid-Antomarchi H; Littman DR; Hirn M; Rossi B; Devaux C; Laboratoire d'Immunologie des Infections Retrovirales, Centre; National de la Recherche Scientifique UPR9008, Institute de; Biologie, Montpellier, France.; Monoclonal antibodies (MAb) directed against the immunoglobulin complementary determining region 3 (CDR3)-like region of the CD4 molecule inhibit human immunodeficiency virus type 1 (HIV-1) transcription. We report here data showing that the cytoplasmic tail of CD4 is required for such inhibition to be achieved. To th
Intrahost human immunodeficiency virus type 1 evolution is related to length of the immunocompetent period.: J Virol. 1995 Nov;69(11):6911-6. Unique Identifier : AIDSLINE MED/96013791; Lukashov VV; Kuiken CL; Goudsmit J; Human Retrovirus Laboratory, University of Amsterdam, The; Netherlands.; The antigenic diversity threshold theory predicts that antigenic sites of human immunodeficiency virus type 1, such as the V3 region of the external glycoprotein gp120, evolve more rapidly during the symptom-free period in individuals progressing to AIDS than in those who remain asymptomatic for a long time. To test t
Contact of human immunodeficiency virus type 1-infected and uninfected CD4+ T lymphocytes is highly cytolytic for both cells.: J Virol. 1995 Nov;69(11):6925-31. Unique Identifier : AIDSLINE MED/96013793; Heinkelein M; Sopper S; Jassoy C; Institute for Virology and Immunobiology, Wurzburg University,; Germany.; Individuals infected with the human immunodeficiency virus (HIV) experience a marked loss of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the depletion of these cells are not yet understood. In this study, we observed that CD4+ T lymphocytes from HIV type 1 (HIV-1)-infected and uninfec
Evidence that a cell cycle regulator, E2F1, down-regulates transcriptional activity of the human immunodeficiency virus type 1 promoter.: J Virol. 1995 Nov;69(11):6940-6. Unique Identifier : AIDSLINE MED/96013795; Kundu M; Srinivasan A; Pomerantz RJ; Khalili K; Department of Biochemistry and Molecular Biology, Jefferson; Institute of Molecular Medicine, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107, USA.; Proliferation of eukaryotic cells is orchestrated by a series of cellular proteins which participate in various stages of the cell cycle to guide the cell through mitosis. Some of these proteins, including E2F1, play a critical role in G1 and S phases by coordinately regulating expression of several important cell cyc
Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus type 1.: J Virol. 1995 Nov;69(11):6980-93. Unique Identifier : AIDSLINE GENBANK/Z46900; Ibrahim F; de The G; Gessain A; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; France.; A study of simian T-cell leukemia virus type 1 (STLV-1) infection in a captive colony of 23 Macaca tonkeana macaques indicated that 17 animals had high human T-cell leukemia virus type 1 (HTLV-1) antibody titers. Genealogical analysis suggested mainly a mother-to-offspring transmission of this STLV-1. Three long-term
Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.: J Virol. 1995 Nov;69(11):7032-44. Unique Identifier : AIDSLINE MED/96013806; Yao XJ; Subbramanian RA; Rougeau N; Boisvert F; Bergeron D; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de; Medecine, Universite de Montreal, Quebec, Canada.; The Vpr gene product of human immunodeficiency virus type 1 is a virion-associated protein that is important for efficient viral replication in nondividing cells such as macrophages. At the cellular level, Vpr is primarily localized in the nucleus when expressed in the absence of other viral proteins. Incorporation of
A transcript from the long terminal repeats of a murine retrovirus associated with trans activation of cellular genes.: J Virol. 1995 Nov;69(11):7054-60. Unique Identifier : AIDSLINE MED/96013808; Choi SY; Faller DV; Cancer Research Center, Boston University School of Medicine,; Massachusetts 02118, USA.; Infection of human or murine cells with murine leukemia viruses rapidly increases the expression of a number of genes that belong to the immunoglobulin superfamily and are involved in T-lymphocyte activation, including the class I major histocompatibility complex antigens. We have reported recently that the long termi
Persistent infection of macaques with simian-human immunodeficiency viruses.: J Virol. 1995 Nov;69(11):7061-7. Unique Identifier : AIDSLINE MED/96013809; Li JT; Halloran M; Lord CI; Watson A; Ranchalis J; Fung M; Letvin NL; Sodroski JG; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts, USA.; Chimeric simian-human immunodeficiency viruses (SHIV) containing the human immunodeficiency virus type 1 (HIV-1) tat, rev, env, and, in some cases, vpu genes were inoculated into eight cynomolgus monkeys. Viruses could be consistently recovered from the CD8-depleted peripheral blood lymphocytes of all eight animals fo
Syncytium induction in primary CD4+ T-cell lines from normal donors by human immunodeficiency virus type 1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells.: J Virol. 1995 Nov;69(11):7099-105. Unique Identifier : AIDSLINE MED/96013812; Todd BJ; Kedar P; Pope JH; Sir Albert Sakzewski Virus Research Centre, Royal Children's; Hospital, Brisbane, Queensland, Australia.; Human immunodeficiency virus type 1 (HIV-1) isolates classified as syncytium-inducing (SI) or non-SI (NSI) in the MT-2 T-cell line exhibit characteristic sequence differences in the V1-V2 and V3 regions of the env gene. Seven HIV-1 isolates were phenotyped as NSI or SI in the MT-2 cell line. Unexpectedly, all four NSI
Processing of the envelope glycoprotein gp160 in immunotoxin-resistant cell lines chronically infected with human immunodeficiency virus type 1.: J Virol. 1995 Nov;69(11):7122-31. Unique Identifier : AIDSLINE MED/96013815; Duensing TD; Fang H; Dorward DW; Pincus SH; Laboratory of Microbial Structure and Function, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840, USA.; We describe the isolation and characterization of variant cell lines which are chronically infected with the human immunodeficiency virus (HIV) and resistant to the action of immunotoxins directed against the HIV envelope protein. These variants all produce normal levels of HIV proteins, budding virions, and the envel
Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.: J Virol. 1995 Nov;69(11):7138-46. Unique Identifier : AIDSLINE MED/96013817; Cho BC; Shaughnessy JD Jr; Largaespada DA; Bedigian HG; Buchberg AM; Jenkins NA; Copeland NG; Mammalian Genetics Laboratory, ABL-Basic Research Program,; NCI-Frederick Cancer Research and Development Center, Maryland; 21702, USA.; Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. Viral integration at Evi-2 appears to induce disease by disrupting normal Nf1 expression. During our attempts to characterize the nature of the proviruses located at Evi-2, we found
Emergence of virus escape mutants after immunization with epitope vaccine.: J Virol. 1995 Nov;69(11):7147-51. Unique Identifier : AIDSLINE MED/96013818; Weidt G; Deppert W; Utermohlen O; Heukeshoven J; Lehmann-Grube F; Heinrich-Pette-Institut fur Experimentelle Virologie und; Immunologie an der Universitat Hamburg, Germany.; BALB/c and C57BL/6J mice were immunized with recombinant vaccines consisting of lymphocytic choriomeningitis virus CD8+ T-lymphocyte epitopes and a carrier protein. During challenge infection with WE strain lymphocytic choriomeningitis virus, mutants with alterations in distinct amino acid residues of the epitopic non
Protective efficacy of nonneutralizing monoclonal antibodies in acute infection with murine leukemia virus.: J Virol. 1995 Nov;69(11):7152-8. Unique Identifier : AIDSLINE MED/96013819; Pincus SH; Cole R; Ireland R; McAtee F; Fujisawa R; Portis J; Laboratory of Microbial Structure and Function, Rocky Mountain; Laboratories, National Institute of Allergy and Infectious; Diseases, Hamilton, Montana 59840, USA.; We have used an experimental retrovirus infection to study the roles played by different antibodies in resistance to both infection and disease. A molecularly cloned chimeric murine leukemia virus was used to induce acute lethal neurological disease in neonatal mice. A panel of monoclonal antibodies directed against t
An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity.: J Virol. 1995 Nov;69(11):7180-6. Unique Identifier : AIDSLINE MED/96013822; Konvalinka J; Litterst MA; Welker R; Kottler H; Rippmann F; Heuser AM; Krausslich HG; Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Infectious retrovirus particles are derived from structural polyproteins which are cleaved by the viral proteinase (PR) during virion morphogenesis. Besides cleaving viral polyproteins, which is essential for infectivity, PR of human immunodeficiency virus (HIV) also cleaves cellular proteins and PR expression causes
Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains.: J Virol. 1995 Nov;69(11):7196-204. Unique Identifier : AIDSLINE MED/96013824; Goncalves J; Shi B; Yang X; Gabuzda D; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115, USA.; Human immunodeficiency virus type 1 (HIV-1) encodes a Vif protein which is important for virus replication and infectivity. Vif is a cytoplasmic protein which exists in both membrane-associated and soluble forms. The membrane-associated form is an extrinsic membrane protein which is tightly associated with the cytopla
Selective infection of human T-lymphotropic virus type 1 (HTLV-1)-infected cells by chimeric human immunodeficiency viruses containing HTLV-1 tax response elements in the long terminal repeat.: J Virol. 1995 Nov;69(11):7216-25. Unique Identifier : AIDSLINE MED/96013826; Lin HC; Bodkin M; Lal RB; Rabson AB; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway, USA.; Previous studies have suggested that the human immunodeficiency virus long terminal repeat (HIV LTR) enhancer/promoter sequences contribute to the replication ability of HIV in different T-cell lines; mutation of these sequences can alter HIV tropism. We have utilized site-specific mutagenesis to generate variants of
Human T-lymphotropic virus type 1 in coastal natives of British Columbia: phylogenetic affinities and possible origins.: J Virol. 1995 Nov;69(11):7248-56. Unique Identifier : AIDSLINE GENBANK/U32558; Picard FJ; Coulthart MB; Oger J; King EE; Kim S; Arp J; Rice GP; Dekaban GA; Gene Therapy and Molecular Virology Group, John P. Robarts; Research Institute, London, Ontario, Canada.; Human T-lymphotropic virus type 1 (HTLV-1) infection has been discovered recently in people of Amerindian descent living in coastal areas of British Columbia, Canada . DNA sequencing combined with phylogenetic analysis and restriction fragment length polymorphism (RFLP) typing of HT
Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani.: J Virol. 1995 Nov;69(11):7282-5. Unique Identifier : AIDSLINE MED/96013837; Bernier R; Turco SJ; Olivier M; Tremblay M; Centre de Recherche en Infectiologie, Centre Hospitalier de; l'Universite Laval, Faculte de Medecine, Universite Laval,; Ste-Foy Quebec, Canada.; In this study, we demonstrated that the protozoan parasite Leishmania donovani and one of its major surface molecules, the lipophosphoglycan (LPG), can induce human immunodeficiency virus type 1 (HIV-1) expression in U1 and OM-10.1, two cell lines of monocytoid origin latently infected with HIV-1. Treatment of U1 cell
Cell cycle dependence of foamy retrovirus infection.: J Virol. 1995 Nov;69(11):7295-9. Unique Identifier : AIDSLINE MED/96013840; Bieniasz PD; Weiss RA; McClure MO; Department of GU Medicine and Communicable Diseases, Jefferiss; Research Trust, St. Mary's Hospital Medical School, London,; United Kingdom.; In common with oncoviruses but unlike the lentivirus human immunodeficiency virus type 1, foamy (spuma) viruses require host cell proliferation for productive infection. We show that human immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of the growth arrest condition of the cells, while murine leuk
Detection of feline immunodeficiency virus in semen from seropositive domestic cats (Felis catus).: J Virol. 1995 Nov;69(11):7328-33. Unique Identifier : AIDSLINE MED/96013847; Jordan HL; Howard J; Tompkins WA; Kennedy-Stoskopf S; Department of Microbiology, Pathology, and Parasitology, College; of Veterinary Medicine, North Carolina State University, Raleigh,; 27606, USA.; Electroejaculates from experimentally infected domestic cats were evaluated for the presence of feline immunodeficiency virus (FIV). Virus was isolated from cell-free seminal plasma and seminal cells by cocultivation with a feline interleukin-2-dependent CD4+ T-cell line, in which productive infection was demonstrated
Regulatory genes of simian immunodeficiency viruses from west African green monkeys (Cercopithecus aethiops sabaeus).: J Virol. 1995 Nov;69(11):7349-53. Unique Identifier : AIDSLINE GENBANK/U21093; Jubier-Maurin V; Sarni-Manchado P; Veas F; Vidal N; Bibollet-Ruche F; Durand JP; Galat-Luong A; Cuny G; Laboratoire Retrovirus, Institute Francais de Recherche; Scientifique pour le Developpment en Cooperation (ORSTOM),; Montpellier, France.; The high seroprevalence of simian immunodeficiency viruses (SIVs) in African green monkeys (AGMs) without immunological defects in their natural hosts has prompted consideration of SIV-infected AGMs as a model of apathogenic SIV infection. Study of the molecular mechanisms of SIVagm asymptomatic infection could thus p
Isolation of a highly cytopathic lentivirus from a nondomestic cat.: J Virol. 1995 Nov;69(11):7371-4. Unique Identifier : AIDSLINE GENBANK/U31349; Barr MC; Zou L; Holzschu DL; Phillips L; Scott FW; Casey JW; Avery RJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, New York 14853, USA.; A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas cat (Otocolobus manul) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-
AIDS and human rights [news]: JAMA. 1995 Nov 22-29;274(20):1577. Unique Identifier : AIDSLINE MED/96074245; Voelker R
[ELISA for diagnosis of infections by viruses]: Nippon Rinsho. 1995 Sep;53(9):2277-82. Unique Identifier : AIDSLINE MED/96008330; Yoshihara N; AIDS Research Center, National Institute of Health.; The assay used most widely to detect or diagnose virus infection, especially infection of blood borne viruses e.g. HBV, HCV, HIV and HTLV, is the enzyme linked immunosorbent assay (ELISA), whose sensitivity and practicability have rendered it the most common primary screening assay. ELISA can be mass screening used au
[New anti-HIV drug which binds the oligosaccharides of HIV envelope glycoprotein]: Nippon Rinsho. 1995 Sep;53(9):2340-9. Unique Identifier : AIDSLINE MED/96008339; Mizuochi T; Nakata M; Department of Applied Chemistry, Tokai University.; The virion surface of the human immunodeficiency virus (HIV-1) is covered with an envelope glycoprotein gp120. Study of the oligosaccharide structures of gp120 suggests that the high mannose type of oligosaccharides are essential for HIV-1 infection. Pradimicin A, an antifungal antibiotic isolated from Actinomadura hi
Pneumocystis carinii pneumonia during treatment for recurrent breast cancer: a case report.: Jpn J Clin Oncol. 1995 Oct;25(5):218-21. Unique Identifier : AIDSLINE MED/96045582; Koibuchi Y; Iino Y; Yokoe T; Oyama T; Nakajima T; Morishita Y; Second Department of Surgery, Gunma University School of; Medicine, Maebashi.; We describe a case of Pneumocystis carinii pneumonia (PCP) in a woman with recurrent breast cancer without human immunodeficiency virus (HIV) infection. The PCP was associated with severe lymphocytopenia due to treatment with anticancer agents in combination with granulocyte colony-stimulating factor (G-CSF). Despite
[Biochemical studies on AIDS dementia complex--possible contribution of quinolinic acid during brain damage]: Rinsho Byori. 1995 Sep;43(9):891-901. Unique Identifier : AIDSLINE MED/96008356; Saito K; Department of Laboratory Medicine, Gifu University School of; Medicine.; AIDS dementia complex (ADC) is a complex, progressive neuropsychiatric syndrome seen in 60-70% of the patients with AIDS. The structural and functional changes associated with ADC may be the result of a variety of indirect mechanisms mediated via activated brain cells or/and virus
Apoptosis of HIV-infected cells following treatment with Sho-Saiko-to and its components.: Jpn J Med Sci Biol. 1995 Apr;48(2):79-87. Unique Identifier : AIDSLINE MED/96022735; Wu X; Akatsu H; Okada H; Department of Molecular Biology, Nagoya City University School of; Medicine.; Baicalein and baicalin are components of Sho-saiko-to (SST), a Chinese medical drug which is claimed to be therapeutically effective in treating HIV-infected patients. Although 20 micrograms/ml of baicalin was not cytotoxic to CEM cells, a cultured T cell line, it proved to be cytotoxic to HIV-infected CEM cells (CEM-
[Retinitis due to cytomegalovirus in AIDS]: Klin Oczna. 1995 Mar-Apr;97(3-4):74-6. Unique Identifier : AIDSLINE MED/96090586; Mackiewicz J; Stransky TJ; Katedry I Kliniki Okulistyki AM w Lublinie.; Clinical course of 4 AIDS patients suffering from CMV retinitis is presented. Two patients were treated with ganciclovir, one died before starting the treatment and one was vitrectomized with silicone oil injection. Of the two patients treated with ganciclovir o
A novel adult T cell leukemia-derived cell line (SALT-3) susceptible to human immunodeficiency virus type 1 infection.: Kurume Med J. 1995;42(3):149-60. Unique Identifier : AIDSLINE MED/96054650; Sagawa K; Koga T; Sasaguri Y; Sadamori N; Nagai K; Department of Immunology, Kurume University School of Medicine,; Japan.; A novel human T cell line (SALT-3) was established from the pleural effusion of a patient with adult T cell leukemia (ATL) of lymphoma type. SALT-3 showed atypical T cell markers such as CD1-CD2-CD3-CD4+CD5+CD7+CD8-CD19-CD20-CD25+HLA-DR+. T cell receptor alpha/beta and gamma/delta were undetectable. Human T cell lymph
Loss of follicular dendritic cells in murine-acquired immunodeficiency syndrome.: Lab Invest. 1995 Oct;73(4):511-20. Unique Identifier : AIDSLINE MED/96027912; Masuda A; Burton GF; Szakal AK; Tew JG; Department of Microbiology and Immunology, Virginia Commonwealth; University, Richmond, USA.; BACKGROUND: The disease caused by HIV-1 leads to the destruction of follicular dendritic cells (FDC) and the follicular architecture in secondary lymphoid tissues. The murine acquired immunodeficiency syndrome (MAIDS, caused by LP-BM5) serves as an animal model for study of mechanisms involved in development of retrov
Telephone access to a university HIV/AIDS clinic.: J Tenn Med Assoc. 1995 Oct;88(10):386-8. Unique Identifier : AIDSLINE MED/96019621; Dorko CS; Morrison RE; Steel G; Arheart KL; Sargent SJ; Department of Medicine, University of Tennessee, Memphis, USA.
Immune responses against multiple epitopes.: J Theor Biol. 1995 Aug 7;175(3):325-53. Unique Identifier : AIDSLINE MED/96030939; Nowak MA; May RM; Sigmund K; Department of Zoology, University of Oxford, U.K.; The current understanding of antigenic escape dynamics is based on models with single epitopes. The usual idea is that a mutation which enables a pathogen (virus, bacteria, etc) to escape from a given immune response confers a selective advantage. The escape mutant may then increase in abundance until it induces a new
Population dynamics of feline immunodeficiency virus within cat populations.: J Theor Biol. 1995 Aug 21;175(4):553-60. Unique Identifier : AIDSLINE MED/96030950; Courchamp F; Pontier D; Langlais M; Artois M; URA CNRS 2055, Universite Lyon I, France.; A deterministic model was constructed for studying the circulation of Feline Immunodeficiency Virus (FIV), a feline retrovirus homologous to Human Immunodeficiency Virus (HIV), within populations of domestic cats. The model has been tested with data generated by a long-term study of several natural cat populations. Si
Correlation between AIDS-related Kaposi sarcoma histological grade and in vitro behavior: reduced exogenous growth factor requirements for isolates from high grade lesions.: Lymphology. 1995 Sep;28(3):126-37. Unique Identifier : AIDSLINE MED/96038359; Bailer RT; Lazo A; Ng-Bautista CL; Hout BL; Ness GM; Hegtvedt AK; Lantry LE; Blakeslee JR; Stephens RE; Brierley GP; et al; Department of Veterinary Pathobiology, Ohio State University,; Columbus, USA.; Kaposi sarcoma, the most common AIDS-associated malignancy, affects 10-30% of all AIDS patients. To date, research into the biological characteristics of AIDS-related Kaposi sarcoma (AIDS-KS) derived cell lines has been based on cultures established from skin explants or pleural effusions/peritoneal fluids. We have es
Clustered hepatitis B or human immunodeficiency virus transmission in office settings.: Lymphology. 1995 Sep;28(3):141-6. Unique Identifier : AIDSLINE MED/96038361; Shields JW
Improved vaccination response during ranitidine treatment, and increased plasma histamine concentrations, in patients with B cell chronic lymphocytic leukemia.: Leukemia. 1995 Nov;9(11):1902-9. Unique Identifier : AIDSLINE MED/96071143; Jurlander J; de Nully Brown P; Skov PS; Henrichsen J; Heron I; Obel N; Mortensen BT; Hansen MM; Geisler CH; Nielsen HJ; Department of Hematology, University Hospital Rigshospitalet,; Copenhagen, Denmark.; Patients with B cell chronic lymphocytic leukemia (B-CLL) have decreased capacity to mount relevant antibody responses upon immunization, and development of hypogammaglobulinemia is part of the natural history of the disease. We investigated the influence of histamine type-2 (H2) receptor blockade by ranitidine on the
Establishment and characterization of a novel cell line, TK-6, derived from T cell blast crisis of chronic myelogenous leukemia, with the secretion of parathyroid hormone-related protein.: Leukemia. 1995 Nov;9(11):1926-34. Unique Identifier : AIDSLINE MED/96071146; Watanabe T; Kataoka T; Mizuta S; Kobayashi M; Uchida T; Imai K; Wada H; Kinoshita T; Murate T; Mizutani S; et al; First Department of Internal Medicine, Nagoya University School; of Medicine, Japan.; We established a novel T cell line, designated TK-6, from a patient with T cell lineage blast crisis of chronic myelogenous leukemia (CML) complicated by hypercalcemia. A surface marker study showed T cell phenotype, cluster designation (CD)4, CD5 and CD7. Light and electron microscopic examination revealed myeloperox
Manipulation of the immune response by foreign gene expression in the thymus.: Leukemia. 1995 Oct;9 Suppl 1:S128-32. Unique Identifier : AIDSLINE MED/96022237; Marshall DJ; Park BH; Korostoff JM; Gaulton GN; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Retroviral gene transfer vectors have been developed for optimal in vivo gene therapy. Ideally, these vectors should target gene expression specifically to selected tissues or organs. Our studies focus on the development of retroviral vectors for gene delivery to the thymus. The goal of these studies is to utilize thy
Glycosylation-dependent peptide antigenic determinants of env gp46 HTLV-1.: Leukemia. 1995 Oct;9 Suppl 1:S133-8. Unique Identifier : AIDSLINE MED/96022238; Kaumaya PT; Conrad SF; DiGeorge AM; Lairmore MD; Department of Obstetrics & Gynecology, College of Medicine, Ohio; State University, Columbus 43210, USA.; Human T-lymphotropic virus type 1 (HTLV-I) is a retrovirus associated with adult T-cell leukemia/lymphoma, and the virus infection constitutes a growing public health problem. In a continuing effort to engineer conformationally dependent HTLV-I epitopes that elicit a protective immune response, we have examined the ro
Gene therapy against retroviral diseases.: Leukemia. 1995 Oct;9 Suppl 1:S71-4. Unique Identifier : AIDSLINE MED/96022225; Essex M; Matsuda Z; Yu X; Lee TH; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; Eventually, gene therapy may be a valid option for chronic viral infections, including retroviral infections. Human retroviral diseases fit two categories: (1) those that result from a monoclonal outgrowth of a human T-cell leukemia virus type I (HTLV-I)-infected cell, as in the case of adult T cell leukemia (ATL); an
Characteristics of a group of nonnucleoside reverse transcriptase inhibitors with structural diversity and potent anti-human immunodeficiency virus activity.: Leukemia. 1995 Oct;9 Suppl 1:S75-85. Unique Identifier : AIDSLINE MED/96022226; Yang SS; Fliakas-Boltz V; Bader JP; Buckheit RW Jr; Antiviral Evaluation Branch, National Cancer Institute, Bethesda,; MD 20892, USA.; Current thrust in controlling the Acquired Immune Deficiency Syndrome (AIDS) focuses on antiviral drug development targeting the infection and replication of the human immunodeficiency virus (HIV), the causative agent of AIDS. To date, treatment of AIDS has relied on nucleoside reverse transcriptase inhibitors such as
Inhibition of human immunodeficiency virus type 1 (HIV) gag gene expression by an antisense oligodeoxynucleotide phosphorothioate.: Leukemia. 1995 Oct;9 Suppl 1:S86-8. Unique Identifier : AIDSLINE MED/96022227; Anazodo MI; Wainberg MA; Friesen AD; Wright JA; Manitoba Institute of Cell Biology, University of Manitoba,; Winnipeg, Canada.; We have employed a cos-like monkey kidney cell line (B4.14) transfected with plasmids pCMVgag-pol-rre-r (containing the HIV gag and pol genes) and pCMVrev (containing the HIV rev gene), as a model to investigate whether antisense constructs could interfere with specific HIV gene and protein expression. We utilized an
The NCI's AIDS antiviral drug screening program.: Leukemia. 1995 Oct;9 Suppl 1:S9-11. Unique Identifier : AIDSLINE MED/96022211; Yang SS; Antiviral Evaluation Branch, National Cancer Institute, Bethesda,; MD 20892, USA.; The Developmental Therapeutics Program (DTP) in the National Cancer Institute has an unique mission by serving as a resource for all academic and private research institutions, the National Institutes of Health in the USA, and the global scientific community in the quest for effective therapeutic agents for treating p
[Antiretroviral treatment against HIV (editorial)]: Med Clin (Barc). 1995 Sep 30;105(10):377-8. Unique Identifier : AIDSLINE MED/96045616; Gonzalez-Lahoz J; Soriano V
[Trends of prevalence of HIV infection in a cohort of parenteral drug users (letter; comment)]: Med Clin (Barc). 1995 Sep 30;105(10):396. Unique Identifier : AIDSLINE MED/96045620; Bolao F; Ramon JM
[Maniac episode associated with stage C3 HIV infection (letter)]: Med Clin (Barc). 1995 Sep 30;105(10):399. Unique Identifier : AIDSLINE MED/96045624; Bertolin JM; Ortega E; Abril V; Pretel J
[Type 2 human immunodeficiency virus infection (HIV-2) in Spain: analysis of the first 50 cases. Spanish Group for the Study of HIV-2]: Med Clin (Barc). 1995 Sep 9;105(7):241-5. Unique Identifier : AIDSLINE MED/96059191; Soriano V; Gutierrez M; Caballero E; Aguilera A; Cilla G; Lopez I; Instituto de Salud Carlos III, Madrid.; BACKGROUND: Infection by the human immunodeficiency virus type 2 (HIV-2) is endemic in West Africa where it is responsible for many AIDS cases. HIV-2 has been described in subjects in other countries, mainly in African immigrants, although it may also be found in natives. The first cases of HIV-2 infection were identi
[HTLV-I infection in Spain. Analysis of 24 cases identified until November, 1994. Spanish Group for the Study of HTLV-I/II)]: Med Clin (Barc). 1995 Sep 9;105(7):246-50. Unique Identifier : AIDSLINE MED/96059192; Soriano V; Gutierrez M; Vallejo A; Aguilera A; Calderon E; Franco E; Instituto de Salud Carlos III, Madrid.; BACKGROUND: HTLV-I is a human retrovirus which has been implicated in the genesis of tropical spastic paraparesia (TSP), adult T-cell leukemia (ATL) and some patients with uveitis, subacute arthropathies and lymphocytary alveolitis. The virus is endemic in some zones of the Caribbean countries,
[HTLV-II infection in Spain. Analysis of 113 cases identified until November, 1994. Spanish Group for the Study of HTLV/I/II]: Med Clin (Barc). 1995 Sep 9;105(7):251-4. Unique Identifier : AIDSLINE MED/96059193; Soriano V; Gutierrez M; Vallejo A; Tuset C; Dronda F; Pujol E; Instituto de Salud Carlos III, Madrid.; BACKGROUND: HTLV-II is a human retrovirus considered to be responsible for the genesis of some lymphoproliferative and neurologic syndromes. The virus is endemic in some Amerindian and African tribes as well amongst injecting drug addicts (IDA) in North America and Europe. METHODS: The clinical, epidemiologic and viro
[Retrovirus, drugs, and sex: a reflection beyond medicine (editorial)]: Med Clin (Barc). 1995 Sep 9;105(7):255-6. Unique Identifier : AIDSLINE MED/96059194; Leal M
[Value of cerebral SPECT with thallium-201 in the diagnosis of primary cerebral lymphoma in AIDS (letter)]: Med Clin (Barc). 1995 Sep 9;105(7):275. Unique Identifier : AIDSLINE MED/96059199; Romeu J; Fraile M; de las Heras P; Garcia O
[Urgent letter from Haiti]: Med Clin (Barc). 1995 Sep 16;105(8):302-3. Unique Identifier : AIDSLINE MED/96059210; Olle Goig JE; ACTMON apoya al programa de control de la tuberculosis, Hospital; Albert Schweitzer de Haiti.
[Disseminated cryptococcosis with lymphatic and bone marrow involvement in a patient with HIV infection (letter)]: Med Clin (Barc). 1995 Sep 16;105(8):316-7. Unique Identifier : AIDSLINE MED/96059214; Romero JC; Miguelez M; Gonzalez M; Arrieta MJ
[10 years of experiences with HIV and AIDS care. A report from a dermato-venereological clinic]: Lakartidningen. 1995 Nov 8;92(45):4172-4. Unique Identifier : AIDSLINE MED/96075006; Bergbrant IM; Hakansson C; Lowhagen GB; Voog E; Divisionen for hud- och konssjukvard, Sahlgrenska sjukhuset,; Goteborg.
Streptococcus pneumoniae resistant to penicillin and tetracycline associated with HIV seropositivity [letter]: Lancet. 1995 Oct 14;346(8981):1034-5. Unique Identifier : AIDSLINE MED/96011429; Paul J; Kimari J; Gilks CF
Intraocular device for cytomegalovirus infection.: Lancet. 1995 Oct 14;346(8981):983-4. Unique Identifier : AIDSLINE MED/96011403; Ernest JT; Department of Ophthalmology and Visual Science, University of; Chicago, Illinois, USA.
Impact of improved treatment of sexually transmitted disease on HIV infection [letter; comment]: Lancet. 1995 Oct 28;346(8983):1157; discussion 1159-60. Unique Identifier : AIDSLINE MED/96036437; Rygnestad T; Smabrekke L; Nesje L; Talsethagen H; Rogne P; Myhr K; Bentzen I
Impact of improved treatment of sexually transmitted disease on HIV infection [letter; comment]: Lancet. 1995 Oct 28;346(8983):1158. Unique Identifier : AIDSLINE MED/96036439; Foulkes MA; Rida WN; Hoff R
Impact of improved treatment of sexually transmitted disease on HIV infection [letter]: Lancet. 1995 Oct 28;346(8983):1158; discussion 1159-60. Unique Identifier : AIDSLINE MED/96036440; O'Reilly K; Gerbase A; Mertens T; Islam M
Impact of improved treatment of sexually transmitted disease on HIV infection [letter; comment]: Lancet. 1995 Oct 28;346(8983):1158-9; discussion 1159-60. Unique Identifier : AIDSLINE MED/96036441; Whitaker L; Renton A
Unknown multiresistant gram-negative bacterium causing meningitis in HIV-positive patient in Africa [letter]: Lancet. 1995 Oct 28;346(8983):1168. Unique Identifier : AIDSLINE MED/96036463; Drancourt M; Niel L; Raoult D
Nef vaccination against HIV disease [letter]: Lancet. 1995 Oct 28;346(8983):1170. Unique Identifier : AIDSLINE MED/96036467; Montagnier L
Multiple introductions of HIV-1 subtype E into the western hemisphere.: Lancet. 1995 Nov 4;346(8984):1197-8. Unique Identifier : AIDSLINE MED/96054840; Artenstein AW; Coppola J; Brown AE; Carr JK; Sanders-Buell E; Galbarini E; Mascola JR; VanCott TC; Schonbrood P; McCutchan FE; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; There are nine recognised genetic subtypes of HIV-1, and the epidemic in Southeast Asia is largely due to subtype E. We have investigated HIV-1 viral subtypes in 11 Uruguayan military personnel, six with infection acquired during a United Nations deployment to Cambodia and five w
Detection of diverse HIV-1 genetic subtypes in the USA.: Lancet. 1995 Nov 4;346(8984):1198-9. Unique Identifier : AIDSLINE MED/96054841; Brodine SK; Mascola JR; Weiss PJ; Ito SI; Porter KR; Artenstein AW; Garland FC; McCutchan FE; Burke DS; Health Sciences and Epidemiology Department, Naval Health; Research Center, San Diego, CA 92186, USA.; Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these no
Pneumocystis carinii in Africa: an emerging pathogen? [comment]: Lancet. 1995 Nov 11;346(8985):1242-3. Unique Identifier : AIDSLINE MED/96064873; Russian DA; Kovacs JA; Critical Care Medicine Department, National Institutes of Health,; Bethesda, MD, USA.
HIV-1, the brain, and combination therapy.: Lancet. 1995 Nov 11;346(8985):1244-5. Unique Identifier : AIDSLINE MED/96064876; Portegies P; Department of Neurology, University of Amsterdam, Netherlands.
Pneumocystis carinii pneumonia in Zimbabwe [see comments]: Lancet. 1995 Nov 11;346(8985):1258-61. Unique Identifier : AIDSLINE MED/96064881; Malin AS; Gwanzura LK; Klein S; Robertson VJ; Musvaire P; Mason PR; Department of Clinical Pharmacology, University of Zimbabwe,; Harare.; Pneumocystis carinii pneumonia (PCP) is said to be rare in Africa, with reported rates of 0-22% in human-immunodeficiency-virus (HIV) infected individuals with respiratory symptoms. Over one year in a central hospital in southern Africa, 64 HIV-infected patients with acute diffuse pneumonia unresponsive to penicillin
Thalidomide effective for AIDS-related oral ulcers [news]: Lancet. 1995 Nov 11;346(8985):1289. Unique Identifier : AIDSLINE MED/96064890; Thompson C
Update on HIV transmission and pathogenesis [news]: Lancet. 1995 Nov 11;346(8985):1290. Unique Identifier : AIDSLINE MED/96064891; Gozlan M
Malaria, anaemia, and HIV-1 transmission in central Africa [letter]: Lancet. 1995 Nov 11;346(8985):1294-5. Unique Identifier : AIDSLINE MED/96064897; Binda ki Muaka P; Nzita M; Eeckels R
Migration and AIDS [letter]: Lancet. 1995 Nov 11;346(8985):1303. Unique Identifier : AIDSLINE MED/96064915; Wolffers I; Fernandez I
Migration and AIDS [letter]: Lancet. 1995 Nov 11;346(8985):1303-4. Unique Identifier : AIDSLINE MED/96064916; Colvin M; Abdool Karim SS; Wilkinson D
HIV-associated diarrhoea and wasting [letter]: Lancet. 1995 Nov 11;346(8985):1304. Unique Identifier : AIDSLINE MED/96064917; Malnick SD
HIV and peacekeeping operations in Cambodia [letter]: Lancet. 1995 Nov 11;346(8985):1304-5. Unique Identifier : AIDSLINE MED/96064918; Soeprapto W; Ertono S; Hudoyo H; Mascola J; Porter K; Gunawan S; Corwin AL
Attenuated HIV-1 strains share gene deletions [news]: Lancet. 1995 Nov 18;346(8986):1357. Unique Identifier : AIDSLINE MED/96064943; McCarthy M
FDA advised to license three anti-HIV agents [news]: Lancet. 1995 Nov 18;346(8986):1358. Unique Identifier : AIDSLINE MED/96064945; Nelson H
Netherlands revises HIV coordination efforts [news]: Lancet. 1995 Nov 18;346(8986):1358. Unique Identifier : AIDSLINE MED/96064944; Spanjer M
Kaposi's sarcoma and KSHV [letter; comment]: Lancet. 1995 Nov 18;346(8986):1359. Unique Identifier : AIDSLINE MED/96064946; Noel JC
Kaposi's sarcoma and KSHV [letter; comment]: Lancet. 1995 Nov 18;346(8986):1359-60. Unique Identifier : AIDSLINE MED/96064947; Shingadia D; Howard MR; Brink NS; Gibb D; Klein N; Tedder R; Novelli V
Kaposi's sarcoma and KSHV [letter; comment]: Lancet. 1995 Nov 18;346(8986):1360. Unique Identifier : AIDSLINE MED/96064948; Ioachim HL
Kaposi's sarcoma and KSHV [letter; comment]: Lancet. 1995 Nov 18;346(8986):1360-1. Unique Identifier : AIDSLINE MED/96064949; Franceschi S; Serraino D
Is HIV the cause of AIDS? [letter]: Lancet. 1995 Nov 18;346(8986):1371-2. Unique Identifier : AIDSLINE MED/96064969; Duesberg PH
Long-term non-progression in HIV infection [letter]: Lancet. 1995 Nov 18;346(8986):1372. Unique Identifier : AIDSLINE MED/96064970; Strathdee SA; Craib KJ; Hogg RS; O'Shaughnessy MV; Montaner JS; Schechter MT
Dual infection with HIV-1 Thai subtype B and E [letter]: Lancet. 1995 Nov 18;346(8986):1372-3. Unique Identifier : AIDSLINE MED/96064971; Xin KQ; Ma XH; Crandall KA; Bukawa H; Ishigatsubo Y; Kawamoto S; Okuda K
Coming clean about needle exchange [editorial]: Lancet. 1995 Nov 25;346(8987):1377. Unique Identifier : AIDSLINE MED/96075436
HIV-infected healthcare workers: results from a straw poll [letter]: Lancet. 1995 Nov 25;346(8987):1425. Unique Identifier : AIDSLINE MED/96075459; Pell J; Gruer L
Mortality and haemophilia [letter]: Lancet. 1995 Nov 25;346(8987):1425-6. Unique Identifier : AIDSLINE MED/96075460; Goedert JJ
HIV infection in Cuban women [letter]: Lancet. 1995 Nov 25;346(8987):1426. Unique Identifier : AIDSLINE MED/96075461; Diaz Alonso G; Alvarez Sintes R; Ramirez Fernandez R
Mucociliary clearance abnormalities in the HIV-infected patient: a precursor to acute sinusitis.: Laryngoscope. 1995 Nov;105(11):1202-8. Unique Identifier : AIDSLINE MED/96069679; Milgrim LM; Rubin JS; Small CB; Department of Otolaryngology, Mount Sinai Medical Center, New; York, N.Y., USA.; An increasing number of patients with human immunodeficiency virus (HIV) suffer from acute infectious sinusitis, and many suffer recurrent episodes at a higher rate than their non-HIV counterparts. This study investigates a mechanism underlying the increased incidence of sinusitis, that of prolonged mucociliary transp
Influence of human granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein (PIXY321) on the hematopoietic toxicity associated with anti-viral drugs (zidovudine and didanosine) in vitro using normal human marrow cells.: Life Sci. 1995;57(18):PL265-73. Unique Identifier : AIDSLINE MED/96035980; Gallicchio VS; Hughes NK; Division of Hematology/Oncology, Markey Cancer Center, University; of Kentucky, Lexington 40536-0084, USA.; The antiviral drugs didanosine (ddI) and zidovudine ( AZT ), synthetic nucleoside analogs, have been used in the treatment of acquired immunodeficiency syndrome (AIDS). Although clinical use of zidovudine (AZT) is still widely used, it is associated wit
In vivo effects of superantigens.: Life Sci. 1995;57(19):1717-35. Unique Identifier : AIDSLINE MED/96068852; Blackman MA; Woodland DL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; Superantigens are potent immunostimulatory molecules that activate both T cells and antigen presenting cells. The consequences of superantigen exposure range from induction of T cell proliferation, massive cytokine release and systemic shock to immunosuppression and tolerance. Superantigens have been directly implicat
Immune response to changes in training intensity and volume in runners.: Med Sci Sports Exerc. 1995 Aug;27(8):1111-7. Unique Identifier : AIDSLINE MED/96021390; Kajiura JS; MacDougall JD; Ernst PB; Younglai EV; Department of Kinesiology, McMaster University, Hamilton,; Ontario, Canada.; We examined the acute and chronic effects of changes in training volume and intensity on the blood lymphocyte percentages and immunoglobulin levels in runners. Twelve runners participated in four 10-d phases of low volume/low intensity (LV/LI), high volume/low intensity (HV/LI), or high volume/high intensity (HV/HI) r
[HIV infection in a patient with chronic cutaneous lupus]: Medicina (B Aires). 1991;51(6):545-7. Unique Identifier : AIDSLINE MED/96036788; Montero A; Jorfen M; Arpini R; Hospital de Emergencias Dr. Clemente Alvarez, Rosario, Argentina.; We present a case of chronic cutaneous lupus erythematosus (CCLE) in a patient who subsequently became infected with human immunodeficiency virus, HIV-1. The symptoms attributed to CCLE had persisted for years, and curiously had disappeared by the time the patient probably became infected with HIV-1. Even if there is
Natural selection on the gag, pol, and env genes of human immunodeficiency virus 1 (HIV-1).: Mol Biol Evol. 1995 Sep;12(5):803-13. Unique Identifier : AIDSLINE GENBANK/K03454; Seibert SA; Howell CY; Hughes MK; Hughes AL; Department of Biology, Pennsylvania State University, University; Park 16802, USA.; Natural selection on polymorphic protein-coding loci of human immunodeficiency virus-1 (HIV-1), the more geographically widespread of the two viruses causing human acquired immune deficiency syndrome (AIDS), was studied by estimating the rates of nucleotide substitution per site in comparisons among alleles classified
Prevalence of antibodies against an immunodominant region of the HIV-1 envelope glycoprotein gp41 in sera from HIV-1 infected individuals in Brazil.: Mem Inst Oswaldo Cruz. 1994 Jul-Sep;89(3):369-70. Unique Identifier : AIDSLINE MED/96001436; Bongertz V; Morgado MG; Departamento de Immunologia, Instituto Oswaldo Cruz, Rio de; Janeiro, RJ, Brasil.
Ultrastructural study on experimental infection of rotavirus in a murine heterologous model.: Mem Inst Oswaldo Cruz. 1994 Jul-Sep;89(3):395-402. Unique Identifier : AIDSLINE MED/96001440; Majerowicz S; Kubelka CF; Stephens P; Barth OM; Departamento de Virologia, Instituto Oswaldo Cruz, Rio de; Janeiro, Brasil.; Viral replication, histopathological and ultrastructural changes were observed for a period of nine days in the small intestine of suckling mice infected with a simian rotavirus (SA11). Samples taken from duodenum, jejunum and ileum were prepared for light microscopy, transmission and scanning electron microscopy anal
Thiol compounds and adult T-cell leukemia virus infection: a potential therapeutic approach.: Methods Enzymol. 1995;252:343-8. Unique Identifier : AIDSLINE MED/96082927; Sato N; Iwata S; Yamauchi A; Hori T; Yodoi J; Department of Biological Responses, Kyoto University, Japan.
HIV and the cortisol connection: a feasible concept of the process of AIDS.: Med Hypotheses. 1995 Jun;44(6):483-9. Unique Identifier : AIDSLINE MED/96038373; Corley PA; Recent evidence suggests that HIV infection and the clinical and laboratory manifestations of acquired immunodeficiency syndrome (AIDS) are a result of the genetic influence of the virus on cellular adrenocorticotrophic hormone (ACTH) and cortisol metabolism. Recent genetic studies substantiate this view with the obse
Plant bacterial spores, active systemically as a separate entity, play a significant role in human illnesses such as cancer, granulomas, AIDS, and milky white abdominal ascites that currently defies recognition.: Med Hypotheses. 1995 Jun;44(6):493-503. Unique Identifier : AIDSLINE MED/96038375; White MW; Greater Detroit Hospital Medical Centers, Inc., Hamtramck, MI; 48212, USA.; There is currently an unrecognized chapter in medical illnesses, occurring in living human beings, that defies recognition in explaining the diseases origin and growth, and failing accurately to account for the pathophysiology involved. It is pertinent, therefore, to alert medical science, based upon facts as uncover
Apoptosis and HIV neuropathogenesis.: Med Hypotheses. 1995 Jun;44(6):536-8. Unique Identifier : AIDSLINE MED/96038381; Espey MG; Biology Department, Georgetown University, Washington, DC 20057,; USA.; A consequence of HIV infection may be neurological dysfunction secondary to the presence of virus in the central nervous system (CNS). The CNS tropism of HIV and the mechanisms that govern its dissemination are not well defined. One view is that HIV enters the brain through the diapedesis of infected monocytes from bl
Cytomegalovirus retinitis in patients with AIDS: current status.: Med J Aust. 1995 Nov 6;163(9):489-92. Unique Identifier : AIDSLINE MED/96085000; Luckie AP; Department of Ophthalmology, University of Melbourne, VIC.; About 20%-30% of patients with AIDS will develop cytomegalovirus ( CMV ) retinitis when they are severely immunodeficient (CD4 cell count below 40 cells/microL). It causes extensive retinal damage with visual deficits, and rela
[Neurological manifestations in HIV-infected child]: Minerva Pediatr. 1995 Jul-Aug;47(7-8):285-95. Unique Identifier : AIDSLINE MED/96019690; Bossi G; Maccabruni A; Caselli D; Astori MG; Piazza F; Clinica Pediatrica, Policlinico San Matteo IRCCS, Pavia.; The authors describe the main epidemiological, pathogenetic and clinical features of HIV-related encephalopathy in 50 pediatric patients (36 females, 24 males), born to HIV-seropositive mothers or infected by contaminated blood, observed in the Institute of Infectious Diseases of Pavia, between January 1984 and Decemb
Torsade de pointes and elevated magnesium and calcium requirements associated with intravenous pentamidine.: Nutr Clin Pract. 1994 Oct;9(5):191-5. Unique Identifier : AIDSLINE MED/96037612; Olree K; Stein-Gocken J; We present a report of markedly elevated calcium and magnesium requirements in an AIDS patient receiving central venous nutrition. These increased requirements were attributed to urinary magnesium losses associated with intravenous pentamidine therapy. The combination of intravenous pentamidine and electrolyte abnorma
Third international conference on nutrition and HIV/AIDS focuses on the issues.: Nutr Clin Pract. 1994 Dec;9(6):254. Unique Identifier : AIDSLINE MED/96037623; Guenther P
Critical neurologic illness in the immunocompromised patient.: Neurol Clin. 1995 Aug;13(3):659-77. Unique Identifier : AIDSLINE MED/96015342; Cohen JA; Raps EC; Mellon Center for Multiple Sclerosis, Cleveland, Ohio, USA.; Immunocompromised patients are vulnerable to a host of neurologic problems that may complicate their clinical course and necessitate intensive care. Atypical and opportunistic infections represent the primary concern in such patients and can cause a variety of neurologic complications. In addition, these patients are
First 500,000 AIDS cases--United States, 1995.: MMWR Morb Mortal Wkly Rep. 1995 Nov 24;44(46):849-53. Unique Identifier : AIDSLINE MED/96074476; As of October 31, 1995, a total of 501,310 persons with acquired immunodeficiency syndrome (AIDS) have been reported to CDC by state and territorial health departments; 311,381 (62%) had been reported as having died. The AIDS surveillance case definition was substantially expanded in late 1987 and again in 1993 to ref
Diphtheritic neuropathy.: Muscle Nerve. 1995 Dec;18(12):1460-3. Unique Identifier : AIDSLINE MED/96074491; Creange A; Meyrignac C; Roualdes B; Degos JD; Gherardi RK; Service de Neurologie, Centre Hospitalier Universitaire Henri; Mondor, Creteil, France.; A 29-year-old Haitian man had a sore throat with a marked tonsillar exudate followed by the onset of increasingly blurred vision with swallowing difficulties and, then, a diffuse acute demyelinating neuropathy. Cerebrospinal fluid showed moderate pleiocytosis and elevated protein content. Serological testing for dipht
Cryptococcosis in a cat seropositive for feline immunodeficiency virus.: Mycoses. 1995 Mar-Apr;38(3-4):131-3. Unique Identifier : AIDSLINE MED/96046117; Cabanes FJ; Abarca ML; Bonavia R; Bragulat MR; Castella G; Ferrer L; Faculty of Veterinary Medicine, Autonomous University of; Barcelona, Spain.; A 5-year-old female Siamese cat was presented to the veterinary teaching hospital with a history of bronchopneumonia for 20 days. The cat had not responded to antibacterial chemotherapy and had developed a pronounced submandibular lymphadenopathy. Characteristically encapsulated yeast cells with narrow-necked buds wer
Xenotransplantation and xenogeneic infections.: N Engl J Med. 1995 Nov 30;333(22):1498-501. Unique Identifier : AIDSLINE MED/96055089; Chapman LE; Folks TM; Salomon DR; Patterson AP; Eggerman TE; Noguchi PD; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.
A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group.: N Engl J Med. 1995 Dec 7;333(23):1528-33. Unique Identifier : AIDSLINE MED/96067435; Danner SA; Carr A; Leonard JM; Lehman LM; Gudiol F; Gonzales J; Raventos A; Rubio R; Bouza E; Pintado V; et al; Academic Medical Center, Amsterdam, The Netherlands.; BACKGROUND. Reverse-transcriptase inhibitors have only moderate clinical efficacy against the human immunodeficiency virus type 1 (HIV-1). Ritonavir is an inhibitor of HIV-1 protease with potent in vitro anti-HIV properties and good oral bioavailabili
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection.: N Engl J Med. 1995 Dec 7;333(23):1534-9. Unique Identifier : AIDSLINE MED/96067436; Markowitz M; Saag M; Powderly WG; Hurley AM; Hsu A; Valdes JM; Henry D; Sattler F; La Marca A; Leonard JM; et al; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; BACKGROUND. Ritonavir is a potent inhibitor in vitro of human immunodeficiency virus type 1 (HIV-1) protease, which is needed for virions to mature and become infective. We assessed the safety and efficacy of ritonavir in patients with HIV-1 infection
Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. North American HIV Working Party [see comments]: N Engl J Med. 1995 Dec 21;333(25):1662-9. Unique Identifier : AIDSLINE MED/96083638; Eron JJ; Benoit SL; Jemsek J; MacArthur RD; Santana J; Quinn JB; Kuritzkes DR; Fallon MA; Rubin M; University of North Carolina at Chapel Hill 27599-7030, USA.; BACKGROUND. The reverse-transcriptase inhibitor lamivudine has in vitro synergy with zidovudine against the human immunodeficiency virus (HIV). We studied the activity and safety of lamivudine plus zidovudine as compared with either drug alone as treatment for patients with HIV infection, most of whom had not previous
A quarter-century of antiviral therapy [editorial; comment]: N Engl J Med. 1995 Dec 21;333(25):1704-5. Unique Identifier : AIDSLINE MED/96083645; Merigan TC
Duesberg and AIDS [letter]: Nature. 1995 Oct 26;377(6551):672. Unique Identifier : AIDSLINE MED/96042541; Derbyshire SW
Human immunodeficiency virus. Trapped but still dangerous [news; comment]: Nature. 1995 Oct 26;377(6551):680-1. Unique Identifier : AIDSLINE MED/96042544; Schrager LK; Fauci AS
Follicular dendritic cells and human immunodeficiency virus infectivity [see comments]: Nature. 1995 Oct 26;377(6551):740-4. Unique Identifier : AIDSLINE MED/96042553; Heath SL; Tew JG; Tew JG; Szakal AK; Burton GF; Department of Microbiology & Immunology, Virginia Commonwealth; University, Richmond 23298-0678, USA.; Large amounts of human immunodeficiency virus (HIV) localize on follicular dendritic cells (FDC) in the follicles of secondary lymphoid tissues following viral infection. During clinical latency, active viral infection occurs primarily at these sites. As HIV on FDC is in the form of immune complexes, some of which may
HIV and AIDS [letter; comment]: Nature. 1995 Nov 2;378(6552):10. Unique Identifier : AIDSLINE MED/96060992; Sullivan JS; Learmont JC; Geczy AF; Dyer W
A sex difference in the human brain and its relation to transsexuality [see comments]: Nature. 1995 Nov 2;378(6552):68-70. Unique Identifier : AIDSLINE MED/96061003; Zhou JN; Hofman MA; Gooren LJ; Swaab DF; Graduate School Neurosciences Amsterdam, Netherlands Institute; for Brain Research, The Netherlands.; Transsexuals have the strong feeling, often from childhood onwards, of having been born the wrong sex. The possible psychogenic or biological aetiology of transsexuality has been the subject of debate for many years. Here we show that the volume of the central subdivision of the bed nucleus of the stria terminals (BST
Cloning of a new cytokine that induces IFN-gamma production by T cells.: Nature. 1995 Nov 2;378(6552):88-91. Unique Identifier : AIDSLINE MED/96061009; Okamura H; Tsutsi H; Komatsu T; Yutsudo M; Hakura A; Tanimoto T; Torigoe K; Okura T; Nukada Y; Hattori K; et al; Department of Bacteriology, Hyogo College of Medicine,; Nishinomiya, Japan.; The mechanism underlying the differentiation of CD4+ T cells into functionally distinct subsets (Th1 and Th2) is incompletely understood, and hitherto unidentified cytokines may be required for the functional maturation of these cells. Here we report the cloning of a recently identified IFN-gamma-inducing factor (IGIF
HIV-blood scientist defends reporting delay [news] [see comments]: Nature. 1995 Nov 2;378(6552):9. Unique Identifier : AIDSLINE MED/96060988; Appel A
Causes of death in haemophilia [letter]: Nature. 1995 Nov 9;378(6553):124. Unique Identifier : AIDSLINE MED/96069721; Ehmann WC; Eyster ME; Aledort LM; Goedert JJ
France backs off promise to boost UN AIDS programme [news]: Nature. 1995 Nov 16;378(6554):224. Unique Identifier : AIDSLINE MED/96069746; Butler D
Protecting HIV databases [letter]: Nature. 1995 Nov 16;378(6554):242-4. Unique Identifier : AIDSLINE MED/96069755; Korber BT; Learn G; Mullins JI; Hahn BH; Wolinsky S
Partial activation of CD8+ T cells by a self-derived peptide.: Nature. 1995 Nov 16;378(6554):295-8. Unique Identifier : AIDSLINE MED/96069766; Cao W; Tykodi SS; Esser MT; Braciale VL; Braciale TJ; Beirne B. Carter Center for Immunology Research, University of; Virginia Health Sciences Center, Charlottesville 22908, USA.; T cells are normally activated when the peptide for which they are specific is presented to them in the context of the appropriate major histocompatibility complex (MHC) (class I and Class II for CD8+ and CD4+ T cells, respectively). An increasing body of evidence indicates that structural homologues of the immunogeni
AIDS vaccine 'needs focused effort' as drug firms back off research [news]: Nature. 1995 Nov 23;378(6555):323-4. Unique Identifier : AIDSLINE MED/96077089; Butler D
[Prevalence of HIV infection among drug users in Zuid-Limburg]: Ned Tijdschr Geneeskd. 1995 Sep 23;139(38):1936-40. Unique Identifier : AIDSLINE MED/96010944; Wiessing LG; Houweling H; Meulders WA; Cerda E; Jansen M; Sprenger MJ; Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor; Infectieziekten Epidemiologie, Bilthoven.; OBJECTIVES. To assess the prevalence of HIV infection among intravenous (IDU) and non-intravenous drug users in Heerlen and Maastricht (Southern Netherlands ), to detect subgroups of IDU with a higher risk of HIV infection, and to assess the risk of further spread of HIV. DESIG
Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy.: Neuropathol Appl Neurobiol. 1995 Jun;21(3):208-17. Unique Identifier : AIDSLINE MED/96059602; Gelbard HA; James HJ; Sharer LR; Perry SW; Saito Y; Kazee AM; Blumberg BM; Epstein LG; Department of Neurology (Child Neurology Division), University of; Rochester Medical Center.; The pathogenesis of human immunodeficiency virus type 1 (HIV-1) associated dementia in adults involves neuronal loss from discrete areas of the neocortex and subcortical regions, but the mechanism for neuronal death is poorly understood. Gene-directed cell death resulting in apopto
Neuronal apoptosis in HIV infection in adults.: Neuropathol Appl Neurobiol. 1995 Jun;21(3):218-27. Unique Identifier : AIDSLINE MED/96059603; Adle-Biassette H; Levy Y; Colombel M; Poron F; Natchev S; Keohane C; Gray F; Department of Pathology (Neuropathology), Hopital H. Mondor,; Universite Paris-Val de Marne, Creteil, France.; Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV-positive patients. The mechanism of neuronal damage is unknown. To enquire whether ne
Plexus neuropathy following vaccination against tick-borne encephalitis and tetanus due to a sports related altered immune state.: Neurol Res. 1995 Aug;17(4):316-9. Unique Identifier : AIDSLINE MED/96000750; Sander D; Scholz C; Eiben P; Klingelhofer J; Department of Neurology, Technical University Munich, Germany.; A 45-year-old female patient who was practising sports on a competition level, developed a plexus neuropathy subsequent to a vaccination against tick-borne encephalitis (TBE) followed by an inoculation of tetanus toxoid six days later. After the TBE vaccination she continued to exercise intensely until symptoms of a n
Spatial data analysis in the quantitative assessment of cerebral white matter pathology on MRI in HIV infection.: Neuroradiology. 1995 Aug;37(6):429-33. Unique Identifier : AIDSLINE MED/96038430; Corrigall RJ; Chong WK; Paley M; Wilkinson ID; Lantos P; Everall I; Maudsley Hospital, London, UK.; This study was carried out using MRI (proton density--and T2-weighted) on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25 with CDC IV HIV disease. The studies from this last group had previously been allocated by a radiologist to the following categories: 8 with focal mass lesions and normal-appe
Cutaneous innervation