1996

HIV+/AIDS : the facts and the future. [videorecording]: St. Louis : Mosby-Year Book, c1995 3 videocassettes : sd., col. ; 1/2 in. + 3 manuals Unique Identifier : AIDSLINE AV/9516089; Scherr SK
Prevention and management for the exposed healthcare provider. [videorecording]: Rosemont, Ill. : American Association of Oral and Maxilliofacial Surgeons, c1993 1 videocassette (45 min.) : sd., col. ; 1/2 in (Video continuing education series ; A300V) Unique Identifier : AIDSLINE AV/9505101; Myall RW
The:family and HIV.: London ; New York, NY : Cassell, 1994 xviii, 282 p. : ill Unique Identifier : AIDSLINE CAT/9510648; Bor R; Elford J
AIDS : a guide to the law. 2nd ed.: London ; New York : Routledge, 1995 xii, 185 p Unique Identifier : AIDSLINE CAT/9515016; Haigh R; Harris D
Evaluation of a national AIDS programme : a methods package.: Geneva : World Health Organization, 1994- v. : ill Unique Identifier : AIDSLINE CAT/9506995
Handbook for HIV prevention community planning.: Washington, D.C. : Academy for Educational Development, [1994] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9515225
HIV and dementia : proceedings of the NIMH-sponsored conference Pathogenesis of HIV infection of the brain: impact on function and behavior.: Berlin ; New York : Springer, c1995 xii, 279 p. : ill (Current topics in microbiology and immunology, ISSN 0070-217X ; 202) Unique Identifier : AIDSLINE CAT/9516647; Oldstone MB; Vitkovic L
Planning and evaluating HIV/AIDS prevention programs in state and local health departments : a companion to program announcement #300.: [Washington, D.C.?] : U.S. Dept. of Health & Human Services, Public Health Service, Centers for Disease Control and Prevention, [1993] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9515428; Schechter C
The:search for an AIDS vaccine : ethical issues in the development and testing of a preventive HIV vaccine.: Bloomington : Indiana University Press, c1995 193 p (Medical ethics series) Unique Identifier : AIDSLINE CAT/9514771; Grady C
Adverse reactions to HIV vaccines : medical, ethical, and legal issues.: Washington, D.C. : Congress of the United States, Office of Technology Assessment : For sale by the U.S. G.P.O., Supt. of Docs., [1995] viii, 197 p. : ill (HIV-related issues. Background paper ; 11) Unique Identifier : AIDSLINE CAT/9517756
Directory of socio-behavioural research on HIV infection and AIDS in Zimbabwe. 1st ed.: Harare : Blair Research Institute, [1992] 100 p Unique Identifier : AIDSLINE CAT/9516389
HIV care : a comprehensive handbook for providers.: Thousand Oaks, Calif. : Sage Publications, c1995 xxviii, 220 p Unique Identifier : AIDSLINE CAT/9514851; Andrews LJ; Novick LB
In the shadow of the epidemic : being HIV-negative in the age of AIDS.: Durham : Duke University Press, 1995 x, 314 p (Series Q) Unique Identifier : AIDSLINE CAT/9515573; Odets W
[La:personne toxicomane VIH-SIDA et le stress induit chez l'intervenant : compte-rendu de la rencontre des equipes des UHRESS du 21 avril 1993.]: Montreal, Quebec : Gouvernement du Quebec, Ministere de la sante et des services sociaux, Centre quebecois de coordination sur le SIDA, [1993?] 106 p. : ill Unique Identifier : AIDSLINE CAT/9514975
[Le:sida et la societe francaise : rapport au Premier Ministre.]: Paris : La documentation francaise, 1994 324 p. : ill (Collection des rapports officiels, ISSN 0981-3764) Unique Identifier : AIDSLINE CAT/9431098; Montagnier L
AIDS analysis Asia.: London : AIDS Analysis Ltd., v. : ill Unique Identifier : AIDSLINE CAT/9600618
[AIDS = SIDA.] [2. ed.].: Sao Paulo, Brasil : Sarvier, 1990 302 p. : ill Unique Identifier : AIDSLINE CAT/9406371; Lacaz Cd
AIDS, sex, and family planning : a Christian view.: Achimota, Ghana : Africa Christian Press, 1989 92 p. : ill Unique Identifier : AIDSLINE CAT/9512376; Baker K
HIV/AIDS work group on health care access issues for gay and bisexual men of color.: Color [Rockville, Md.] : U.S. Dept. of Health & Human Services, Public Health Service, Health Resources and Services Administration, Bureau of Health Resources Development, [1995?] 55 p (DHHS publication ; no. HRSA 95-4) Unique Identifier : AIDSLINE CAT/9514618
[Pathologie infectieuse et demarche de soins.]: Thoiry : Editions heures de France, c1993 2 v. : ill Unique Identifier : AIDSLINE CAT/9423420; Pebret F
[Rapi Zappeur presente toxico, sida & co.]: [Cherbourg] : Isoete, c1994 55 p. : ill Unique Identifier : AIDSLINE CAT/9430640; Bartier
[Rapport d'activites du programme a moyen terme : juillet 90-janvier 1991.]: Moroni : Le Programme, [1991?] 17 leaves : ill Unique Identifier : AIDSLINE CAT/9515291
[Therapeutique pratique de l'infection par le virus de l'immunodeficience humaine.]: Paris : Med-Line [1993] 176 p. : ill Unique Identifier : AIDSLINE CAT/9430704; Belec L
Exposure to blood and body fluid: factors associated with non-compliance in follow up HIV testing among health care workers.: AAOHN J. 1995 Oct;43(10):507-13. Unique Identifier : AIDSLINE MED/96077846; Sass J; Bertolone K; Denton D; Logsdon MC; Due to lack of previous research, this study examined the factors associated with non-compliance in follow up human immunodeficiency virus (HIV) testing among health care workers after blood and/or body fluid exposure. A descriptive correlation design was used with 178 health care workers who did not return for recomm
Lack of requirement for CD8+ cells in recovery from and resistance to experimental autoimmune encephalomyelitis.: J Autoimmun. 1995 Jun;8(3):395-404. Unique Identifier : AIDSLINE MED/96082299; Lohse AW; Schwerdt A; Herkel J; Spahn T; Meyer zum Buschenfelde KH; Department of Medicine, Johannes Gutenberg-University, Mainz,; Germany.; Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell mediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4+ T-cells, whose adoptive transfer can also induce passive disease. In the Lewis rat EAE is a transient disease inducing lasting resistance to rechallenge. Th
Enhancement of CTL response induced by a viral peptide using cationized BSA, a Th1-stimulating adjuvant.: Viral Immunol. 1994;7(4):179-88. Unique Identifier : AIDSLINE MED/96100712; Vasilakos JP; Michael JG; Department of Molecular Genetics, Biochemistry, and Microbiology,; University of Cincinnati, Ohio 45267-0524, USA.; We have recently shown that it is possible to activate cytotoxic T cells (CTL) in vivo with HSV-1 glycoprotein B H-2Kb-restricted peptide (gB peptide) independent of CD4+ T cell help. Here we report that the gB peptide-specific CTL response is significantly enhanced when mice are immunized with a mixture of gB peptide
Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a noncovalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response.: Viral Immunol. 1994;7(4):189-97. Unique Identifier : AIDSLINE MED/96100713; Nehete PN; Arlinghaus RB; Sastry KJ; Department of Veterinary Sciences, University of Texas M.D.; Anderson Cancer Center, Bastrop 78602, USA.; Our previous reports established that immunization of mice in the footpad with a 15-amino acid synthetic peptide (R15K) from the V3 loop region in the envelope protein gp120 of human immunodeficiency virus type 1 (HIV-1) resulted in rapid induction of major histocompatability complex (MHC) class I-restricted, CD8+ HIV
Serum reactivity against an immunoregulatory sequence of HIV p24 in HIV-1-infected subjects.: Viral Immunol. 1994;7(4):199-203. Unique Identifier : AIDSLINE MED/96100714; Cordiali Fei P; Solmone M; Prignano G; Pugliese O; Viora M; Luzzati A; Ameglio F; Laboratory of Clinical Pathology, Istituto San Gallicano, Rome,; Italy.; The aim of this study was to assess the antibody reactivity in HIV-infected subjects against an HIV-1 p24 sequence, p226 (aa226-237), including a seven amino acid epitope showing immunosuppressive activity in vitro and to evaluate the relationship between anti-peptide antibody levels and disease progression. Sera of H
Immunoglobulin-like domain of HIV-1 envelope glycoprotein gp120 encodes putative internal image of some common human proteins.: Viral Immunol. 1994;7(4):215-9. Unique Identifier : AIDSLINE MED/96100716; Metlas R; Skerl V; Veljkovic V; Colombatti A; Pongor S; Laboratory for Multidisciplinary Research, Institute for Nuclear; Sciences Vinca, Belgrade, Yugoslavia.; By examining sequence similarity between the V3-loop of gp120 from various HIV-1 isolates and human proteins, we found that the V3 loop portion KKGIAIGPGR in strain New York 5 (HIV-1NY5) shares 70% identical residues with the collagen-like region (CLR) of human complement component C1q-A. C1q CLR was found to react wi
Cellular immune responses of macaques exposed to low doses of SIV [letter]: Immunol Today. 1995 Oct;16(10):501. Unique Identifier : AIDSLINE MED/96045907; Dittmer U; Spring M; Bodemer W; Hunsmann G
Special issue: The 9th International Congress of Immunology. San Francisco, California, 23-29 July 1995.: Immunol Today. 1995 Jul;16(7):305-62. Unique Identifier : AIDSLINE MED/96080657
The immune response to HIV: potential for immunotherapy?: Immunol Today. 1995 Jul;16(7):356-8. Unique Identifier : AIDSLINE MED/96080674; Dalgleish AG; Dept of Cellular and Molecular Sciences, St George's Hospital; Medical School, London, UK.
Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy.: Am J Reprod Immunol. 1995 May;33(5):394-404. Unique Identifier : AIDSLINE MED/96070201; Rukavina D; Rubesa G; Gudelj L; Haller H; Podack ER; Department of Physiology and Immunology, Medical Faculty,; University of Rijeka, Croatia.; PROBLEM: The number of perforin (P)-positive cells in decidua of pregnancy is larger than that observed in any other pathological condition. The aim was to investigate the distribution and the phenotype of P+ cells. METHOD: Decidual tissue was obtained from the first trimester vaginal termination of pregnancy. Tissue
AIDS behind bars: preventing HIV spread among incarcerated drug injectors [editorial]: AIDS. 1995 Aug;9(8):825-32. Unique Identifier : AIDSLINE MED/96014954; Dolan K; Wodak A; Penny R
Encapsulation of foscarnet in liposomes modifies drug intracellular accumulation, in vitro anti-HIV-1 activity, tissue distribution and pharmacokinetics.: AIDS. 1995 Aug;9(8):833-41. Unique Identifier : AIDSLINE MED/96014955; Dusserre N; Lessard C; Paquette N; Perron S; Poulin L; Tremblay M; Beauchamp D; Desormeaux A; Bergeron MG; Centre de Recherche en Infectiologie, Centre Hospitalier de; I'Universite Laval, Ste-Foy, Quebec, Canada.; OBJECTIVE: To improve the in vitro anti-HIV-1 activity, intracellular accumulation in macrophages and in vivo pharmacokinetics and tissue distribution of foscarnet (trisodium phosphonoformate; PFA) by encapsulation in liposomes. METHODS: The accumulation of free and liposome-encapsulated PFA was determined in monocyte
Determination of HIV-1 subtypes in injecting drug users in Bangkok, Thailand, using peptide-binding enzyme immunoassay and heteroduplex mobility assay: evidence of increasing infection with HIV-1 subtype E.: AIDS. 1995 Aug;9(8):843-9. Unique Identifier : AIDSLINE MED/96014956; Wasi C; Herring B; Raktham S; Vanichseni S; Mastro TD; Young NL; Rubsamen-Waigmann H; von Briesen H; Kalish ML; Luo CC; et al; Department of Microbiology, Faculty of Medicine, Siriraj; Hospital, Mahidol University, Bangkok, Thailand.; OBJECTIVES: To evaluate the sensitivity and specificity of peptide-binding enzyme immunoassay (PEIA) and heteroduplex mobility assay (HMA) for the determination of HIV-1 subtypes B and E; to determine the proportions of infections due to subtypes B and E over time; and to generate data on DNA sequences of the C2-V3 re
The evolving molecular epidemiology of HIV-1 envelope subtypes in injecting drug users in Bangkok, Thailand: implications for HIV vaccine trials.: AIDS. 1995 Aug;9(8):851-7. Unique Identifier : AIDSLINE MED/96014957; Kalish ML; Baldwin A; Raktham S; Wasi C; Luo CC; Schochetman G; Mastro TD; Young N; Vanichseni S; Rubsamen-Waigmann H; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; OBJECTIVE: To genetically characterize HIV-1 strains in injecting drug users (IDU) in Bangkok, Thailand in 1994, and compare these with strains found earlier in Thai IDU; such information is essential for HIV-1 vaccine development and evaluation. METHODS: Peripheral blood mononuc
Productive HIV-1 infection of normal human mammary epithelial cells.: AIDS. 1995 Aug;9(8):859-66. Unique Identifier : AIDSLINE MED/96014958; Toniolo A; Serra C; Conaldi PG; Basolo F; Falcone V; Dolei A; Institute of Medicine and Public Health, University of Pavia,; Varese, Italy.; OBJECTIVE AND DESIGN: To determine the susceptibility of mammary epithelial cells (MEC) to HIV-1 as breastfeeding is an established route of HIV transmission, although the origin of virus in breastmilk is unclear. METHODS: Primary epithelial cell cultures were derived from the mammary glands of healthy donors; immorta
Neutralization of primary HIV-1 isolates by anti-envelope monoclonal antibodies.: AIDS. 1995 Aug;9(8):867-74. Unique Identifier : AIDSLINE MED/96014959; D'Souza MP; Milman G; Bradac JA; McPhee D; Hanson CV; Hendry RM; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; OBJECTIVE: To evaluate human monoclonal antibodies (MAb) for neutralizing activity against primary HIV-1 isolates in peripheral blood mononuclear cells. DESIGN: Neutralization activity data were obtained from 11 laboratories on a coded panel consisting of six human MAb to HIV envelope V3, CD4-binding region or gp41. H
Diagnosis and prognosis of AIDS-related cholangitis.: AIDS. 1995 Aug;9(8):875-80. Unique Identifier : AIDSLINE MED/96014960; Ducreux M; Buffet C; Lamy P; Beaugerie L; Fritsch J; Choury A; Liguory C; Longuet P; Gendre JP; Vachon F; et al; Department of Hepato-Gastroenterology, Bicetre Hospital, Le; Kremlin Bicetre, France.; OBJECTIVE: To determine more precisely the clinical and biological characteristics of AIDS-related cholangitis, and to investigate prognostic variables of this disease. DESIGN: Retrospective clinical and prognostic study. SETTING: Biliary unit, Bicetre Hospital, France . PATIENTS: H
Campylobacter infections in HIV-infected patients: clinical and bacteriological features.: AIDS. 1995 Aug;9(8):881-5. Unique Identifier : AIDSLINE MED/96014961; Molina J; Casin I; Hausfater P; Giretti E; Welker Y; Decazes J; Garrait V; Lagrange P; Modai J; Infectious Disease Department, Saint-Louis Hospital, Paris,; France.; OBJECTIVE: To study the clinical and bacteriological features of Campylobacter infections in HIV-infected patients. DESIGN: A retrospective analysis (1989-1992), followed by a prospective analysis (1992-1994). SETTING: Hospital HIV inpatient unit. PATIENTS AND METHODS: All patients with Campylobacter spp. identified b
Micronutrient levels in HIV-1-infected children.: AIDS. 1995 Aug;9(8):887-93. Unique Identifier : AIDSLINE MED/96014962; Periquet BA; Jammes NM; Lambert WE; Tricoire J; Moussa MM; Garcia J; Ghisolfi J; Thouvenot J; Purpan Hospital, Toulouse, France.; OBJECTIVE: Micronutrients (zinc, copper, selenium, vitamin A, E, and carotenoids) are essential for the integrity of host defences. This study was designed to determine the prevalence of abnormalities of the micronutrient levels in HIV-1-seropositive children. DESIGN: Prospective study. SETTING: The study was performe
Nested polymerase chain reaction for diagnosis and monitoring treatment response in AIDS patients with tuberculous meningitis.: AIDS. 1995 Aug;9(8):895-900. Unique Identifier : AIDSLINE MED/96014963; Scarpellini P; Racca S; Cinque P; Delfanti F; Gianotti N; Terreni MR; Vago L; Lazzarin A; Infectious Diseases Department, San Raffaele Scientific; Institute, Milan, Italy.; OBJECTIVE: To investigate the usefulness of polymerase chain reaction (PCR) from cerebrospinal fluid (CSF) for rapid diagnosis and assessing treatment response of tuberculous meningitis (TBM) in AIDS patients. PATIENTS: Forty-four CSF samples from 10 patients with TBM confirmed by autopsy or by a culture of CSF (41 sa
Effects of aerosolized pentamidine on glucose homeostasis and insulin secretion in HIV-positive patients: a controlled study.: AIDS. 1995 Aug;9(8):901-7. Unique Identifier : AIDSLINE MED/96014964; Uzzan B; Bentata M; Campos J; Mosnier A; Krivitzky A; Perret GY; Modigliani E; Department of Pharmacology-Hormonology, Avicenne Hospital, CHU; Paris-Nord, Bobigny, France.; OBJECTIVE: Intravenous pentamidine induces hypo- and hyperglycaemia (dose-dependent toxicity on islet beta cells), pancreatitis and nephrotoxicity. Conversely, aerosolized pentamidine (AP) is usually devoid of systemic side-effects: few reports of hypo- or hyperglycaemia have been published. Our study aimed to assess
HIV infection and invasive cervical carcinoma in an Italian population: the need for closer screening programmes in seropositive patients.: AIDS. 1995 Aug;9(8):909-12. Unique Identifier : AIDSLINE MED/96014965; Zanetta G; Maneo A; Colombo A; Ragusa A; Gabriele A; Placa F; Mangioni C; Department of Obstetrics and Gynaecology, S. Gerardo Hospital,; University of Milan, Monza, Italy.; OBJECTIVE: To evaluate in an Italian population the prevalence, characteristics at first diagnosis and outcome of HIV-seropositive individuals with cervical carcinoma referred to a tertiary-care institution. DESIGN: A retrospective evaluation of all patients referred for invasive cervical carcinoma from 1991 to 1994.
The incidence of complications after caesarean section in 156 HIV-positive women.: AIDS. 1995 Aug;9(8):913-7. Unique Identifier : AIDSLINE MED/96014966; Semprini AE; Castagna C; Ravizza M; Fiore S; Savasi V; Muggiasca ML; Grossi E; Guerra B; Tibaldi C; Scaravelli G; et al; Department of Obstetrics and Gynaecology, San Paolo Biomedical; Institute, Milan, Italy.; OBJECTIVE: To investigate the risks of post-operative complications in HIV-positive mothers who undergo a caesarean section (CS) because the delivery cannot be safely accomplished by the vaginal route or to protect the infant from viral infection. DESIGN: In a multicentre study, we reviewed the incidence and type of p
A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 1. Design.: AIDS. 1995 Aug;9(8):919-26. Unique Identifier : AIDSLINE MED/96014967; Hayes R; Mosha F; Nicoll A; Grosskurth H; Newell J; Todd J; Killewo J; Rugemalila J; Mabey D; London School of Hygiene and Tropical Medicine, UK.; OBJECTIVE: To describe the rationale and design of a randomized trial of the impact of improved services for the treatment of sexually transmitted diseases (STD) on the incidence of HIV infection in Mwanza Region, Tanzania . METHODS: The likely impact of improved STD treatment ser
A community trial of the impact of improved sexually transmitted disease treatment on the HIV epidemic in rural Tanzania: 2. Baseline survey results.: AIDS. 1995 Aug;9(8):927-34. Unique Identifier : AIDSLINE MED/96014968; Grosskurth H; Mosha F; Todd J; Senkoro K; Newell J; Klokke A; Changalucha J; West B; Mayaud P; Gavyole A; et al; African Medical and Research Foundation, Mwanza, Tanzania.; OBJECTIVES: To determine baseline HIV prevalence in a trial of improved sexually transmitted disease (STD) treatment, and to investigate risk factors for HIV. To assess comparability of intervention and comparison communities with respect to HIV/STD prevalence and risk factors. To assess adequacy of sample size. SETTI
Couple communication, sexual coercion and HIV risk reduction in Kigali, Rwanda.: AIDS. 1995 Aug;9(8):935-44. Unique Identifier : AIDSLINE MED/96014969; van der Straten A; King R; Grinstead O; Serufilira A; Allen S; Center for AIDS Prevention Studies, University of California, San; Francisco, USA.; OBJECTIVE: To describe sexual interaction and HIV-related communication in Rwandan couples and to examine their relationship to HIV testing and condom use. STUDY DESIGN: Cross-sectional survey of a longitudinal cohort. METHODS: In 1988, women recruited for an epidemiological study of HIV, and interested male partners,
Use of pooling and outpatient laboratory specimens in an anonymous seroprevalence survey of HIV infection in British Columbia, Canada.: AIDS. 1995 Aug;9(8):945-50. Unique Identifier : AIDSLINE MED/96014970; Sherlock CH; Strathdee SA; Le T; Sutherland D; O'Shaughnessy MV; Schechter MT; Department of Pathology, University of British Columbia,; Vancouver, Canada.; OBJECTIVE: To conduct an anonymous HIV seroprevalence survey to establish a baseline estimate of HIV seroprevalence in a general population; to evaluate serum pooling and alternative testing strategies as cost-saving measures. DESIGN: Prospective anonymous HIV seroprevalence study using outpatient laboratory specimens
HIV status of female sex partners of men reactive to HIV-1, HIV-2 or both viruses in Abidjan, Cote d'Ivoire.: AIDS. 1995 Aug;9(8):951-4. Unique Identifier : AIDSLINE MED/96014971; N'Gbichi JM; De Cock KM; Batter V; Yeboue K; Ackah A; Zadi F; Diallo MO; Kadio A; Gayle HD; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVES: To compare rates of serologic concordance in the female sex partners of men with HIV-1 and HIV-2 infections, and to determine the serologic status of sex partners of men who reacted serologically to both viruses. DESIGN: Cross-sectional study. SETTING: Infectious diseases service in a University Hospital i
Dual seroreactivity to HIV-1 and HIV-2 in female sex workers in Abidjan, Cote d'Ivoire.: AIDS. 1995 Aug;9(8):955-8. Unique Identifier : AIDSLINE MED/96014972; Ghys PD; Diallo MO; Ettiegne-Traore V; Yeboue KM; Gnaore E; Lorougnon F; Teurquetil MJ; Adom ML; Greenberg AE; Laga M; et al; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; OBJECTIVE: To determine the absolute and proportional prevalence of dual seroreactivity to HIV-1 and HIV-2 in female sex workers in Abidjan, to determine risk determinants for this serologic profile, and to describe the associated clinical and immunological characteristics. DESIGN: Cross-sectional study. SETTING: Conf
HIV risk behaviors but absence of infection among drug users in detoxification centers outside Yunnan province, China, 1993.: AIDS. 1995 Aug;9(8):959-63. Unique Identifier : AIDSLINE MED/96014973; Zheng X; Tian C; Zhang G; Li D; Liu X; Hu DJ; Weniger BG; Dondero TJ; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing, China.; OBJECTIVES: To date, HIV spread in China has occurred principally among injecting drug users (IDU) in remote border regions of Yunnan province. We therefore sought to better understand the risks for and prevalence of HIV infection among drug users in parts of China outside Yunnan pr
Decreasing prevalence hides a high HIV incidence: Miami.: AIDS. 1995 Aug;9(8):965-70. Unique Identifier : AIDSLINE MED/96014974; Peterman TA; Zaidi AA; Wroten J; Division of STD/HIV Prevention, Centers for Disease Control,; Atlanta, Georgia 30333, USA.; OBJECTIVE: Study methods of assessing HIV trends in sexually transmitted disease (STD) clinics where blinded seroprevalence has been among the highest in the United States . DESIGN: Cross-sectional and retrospective cohort. METHODS: Reviewed computerized records of the four Miami STD cl
HIV transmission and Kaposi's sarcoma among European women.: AIDS. 1995 Aug;9(8):971-3. Unique Identifier : AIDSLINE MED/96014975; Serraino D; Franceschi S; Dal Maso L; La Vecchia C; Department of Epidemiology, Aviano Cancer Centre, Italy.; OBJECTIVE: To assess the association between the presence of Kaposi s sarcoma (KS) as an AIDS-defining illness and HIV transmission categories among European women with AIDS. DESIGN: Comparison of the prevalence of KS as an AIDS-defining illness in different HIV transmission categories. METHODS: Odds ratios (OR) and 9
Microsporidiosis in patients with relatively preserved CD4 counts [letter]: AIDS. 1995 Aug;9(8):975. Unique Identifier : AIDSLINE MED/96014976; Sowerby TM; Conteas CN; Berlin OG; Donovan J
First case of osteomyelitis due to Phialophora richardsiae in a patient with HIV infection [letter]: AIDS. 1995 Aug;9(8):975-6. Unique Identifier : AIDSLINE MED/96014977; Uberti-Foppa C; Fumagalli L; Gianotti N; Viviani AM; Vaiani R; Gieho E
Plasma HIV-1 load and nosocomial transmission in Romanian children [letter]: AIDS. 1995 Aug;9(8):977. Unique Identifier : AIDSLINE MED/96014978; Apetrei C; Descamps D; Panzaru C; Duca MC; Simon F; Brun-Vezinet F
HIV-1 group O sensitivity to antiretroviral drugs [letter]: AIDS. 1995 Aug;9(8):977-8. Unique Identifier : AIDSLINE MED/96014979; Descamps D; Collin G; Loussert-Ajaka I; Saragosti S; Simon F; Brun-Vezinet F
Production of nitric oxide from peripheral blood mononuclear cells and polymorphonuclear leukocytes of patients with HIV-1 [letter]: AIDS. 1995 Aug;9(8):979-80. Unique Identifier : AIDSLINE MED/96014980; Torre D; Ferrario G; Bonetta G; Speranza F; Zeroli C
Endophthalmitis as a complication of intravitreal treatment for cytomegalovirus retinitis [letter]: AIDS. 1995 Aug;9(8):980-1. Unique Identifier : AIDSLINE MED/96014981; Collazos J; Diaz F; Mayo J; Martinez E; Fernandez A
Comment from the World Bank [letter]: AIDS. 1995 Aug;9(8):982-4. Unique Identifier : AIDSLINE MED/96014982; Feachem R; Musgrove P; Elmendorf AE
A management trial for Duchenne cardiomyopathy.: Am J Phys Med Rehabil. 1995 Sep-Oct;74(5):345-50. Unique Identifier : AIDSLINE MED/96036557; Ishikawa Y; Bach JR; Ishikawa Y; Minami R; Department of Pediatrics, Sapporo University of Medicine,; Hokkaido, Japan.; The physiatrist can now be instrumental in prolonging the survival of individuals with neuromuscular disease by using respiratory muscle aids. As a result, morbidity and mortality from cardiomyopathy are likely to increase for patients with generalized myopathies. One hundred consecutive patients with dystrophin-defic
Six billion neurons lost in AIDS. A stereological study of the neocortex.: APMIS. 1995 Jul-Aug;103(7-8):525-9. Unique Identifier : AIDSLINE MED/96033957; Oster S; Christoffersen P; Gundersen HJ; Nielsen JO; Pedersen C; Pakkenberg B; Neurological Research Laboratory, Kommunehospitalet, Copenhagen,; Denmark.; Human immunodeficiency virus type 1 (HIV1) is neurotropic. One of the morphological changes that is seen in patients with acquired immunodeficiency syndrome (AIDS) is cerebral atrophy affecting various structures including the neocortex. The cause of atrophy is not known. The total number of neocortical neurons was es
Beta 2-microglobulin expression of AIDS-related and classical Kaposi's sarcoma.: APMIS. 1995 Jul-Aug;103(7-8):553-7. Unique Identifier : AIDSLINE MED/96033961; Petersen BL; Petersen CL; Jensen A; Thomsen HK; Werdelin O; Braendstrup O; Department of Pathology, Glostrup Hospital, Denmark.; The expression of beta 2-microglobulin, the invariable light chain of HLA class I molecules, of Kaposi s sarcoma from 11 AIDS patients and from 11 patients without known immunodeficiency was studied by immunohistochemistry using a polyclonal antibody to beta 2-microglobulin. The staining intensity of spindle cells in
Infection, apoptosis, and killing of mature human eosinophils by human immunodeficiency virus-1.: Am J Respir Cell Mol Biol. 1995 Nov;13(5):610-20. Unique Identifier : AIDSLINE MED/96054928; Weller PF; Marshall WL; Lucey DR; Rand TH; Dvorak AM; Finberg RW; Department of Medicine, Harvard Thorndike Laboratories, Charles; A. Dana Research Institute, Beth Israel Hospital, Harvard Medical; School, Boston, Massachusetts 02215, USA.; Although human eosinophils express low concentrations of CD4, the capacity of mature, non-replicating eosinophils to be infected with human immunodeficiency virus-1 (HIV-1) has not been established. Using peripheral blood eosinophils isolated free of contaminating lymphocytes and mononuclear leukocytes, we evaluated e
Detection of a 67-kD glycoprotein in human tumor cell lines by a monoclonal antibody established against a recombinant human endogenous retrovirus-K envelope-gene-encoded protein.: Exp Clin Immunogenet. 1995;12(2):96-102. Unique Identifier : AIDSLINE MED/96100697; Vogetseder W; Feng J; Haibach C; Mayerl W; Dierich MP; Institut fur Hygiene, Leopold-Franzens-Universitat Innsbruck,; Osterreich.; Endogenous retroviruses in humans are discussed as putative etiologic agents in tumorigenesis. Molecular mimicry of cellular epitopes by retroviruses may be of importance for the genesis of autoimmune diseases. A group of human endogenous retroviruses, HERV-K, which is related to the mouse mammary tumour virus, has be
Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates.: AIDS Res Hum Retroviruses. 1995 May;11(5):533-9. Unique Identifier : AIDSLINE MED/96093887; Allaway GP; Davis-Bruno KL; Beaudry GA; Garcia EB; Wong EL; Ryder AM; Hasel KW; Gauduin MC; Koup RA; McDougal JS; et al; Progenics Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.; CD4-IgG2 is a novel fusion protein comprising human IgG2 in which the Fv portions of both heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This tetrameric protein is being developed as an immunoprophylactic agent to reduce the probability of infection following HIV-1 exposure, in settin
Inhibition of HIV type 1 infection of mononuclear phagocytes by anti-CD44 antibodies.: AIDS Res Hum Retroviruses. 1995 May;11(5):541-6. Unique Identifier : AIDSLINE MED/96093888; Rivadeneira ED; Sauls DL; Yu Y; Haynes BF; Weinberg JB; Department of Pediatrics, VA Medical Center, Durham, North; Carolina 27705, USA.; Cellular CD4 is the primary membrane molecule that binds HIV-1 through interaction with viral gp120. Membrane glycolipids and cell adhesion molecules have also been noted to be involved in the interaction of HIV-1 with cells and in syncytium formation in infected cells. The purpose of this study was to determine the r
HIV type 1 grown on interferon gamma-treated U937 cells shows selective increase in virion-associated intercellular adhesion molecule 1 and HLA-DR and enhanced infectivity for CD4-negative cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):547-53. Unique Identifier : AIDSLINE MED/96093889; Castilletti C; Capobianchi MR; Fais S; Abbate I; Ficociello B; Ameglio F; Cordiali Fei P; Santini SM; Dianzani F; Institute of Virology, University La Sapienza, Rome.; Cellular adhesion molecules, such as ICAM-1, -2, and -3; LFA-1; and HLA class I and II are incorporated into HIV-1 virions during budding from infected cells. These virion-associated molecules can be involved in the adsorption to susceptible cells displaying the corresponding counterligands. A number of cytokines have
Insulin-like growth factor 1 and insulin inhibit HIV type 1 replication in cultured cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):555-61. Unique Identifier : AIDSLINE MED/96093890; Germinario RJ; DeSantis T; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.; Insulin-like growth factor 1 and insulin, considered primarily as metabolic and growth modulatory hormones, were found to inhibit the replication of HIV-1 in cultured cord blood mononuclear cells and chronically HIV-infected U937 cells. The effect of IGF-1 was seen at physiological concentrations or lower (1.7 x 10(-1
Characterization of V3 loop-binding protein(s) of Molt-4 and U937 cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):563-70. Unique Identifier : AIDSLINE MED/96093891; Xu Y; Murakami T; Kawase S; Uchiyama T; Hattori T; Laboratory for AIDS Immunology, Kyoto University, Japan.; The V3 loop in gp120 of human immunodeficiency virus type 1 (HIV-1) is known as a principal neutralizing and cell-tropic determinant. Biotinylated synthetic V3 loop peptides derived from three different HIV-1 strains were used as ligands to identify the cell surface counterreceptor, which may participate in the infect
Single basic amino acid substitutions at position 302 or 320 in the V3 domain of HIV type 1 are not sufficient to alter the antiviral activity of dextran sulfate and heparin.: AIDS Res Hum Retroviruses. 1995 May;11(5):571-5. Unique Identifier : AIDSLINE MED/96093892; Okada T; Gurney ME; Department of Cell, Molecular, and Structural Biology,; Northwestern University Medical School, Chicago, Illinois 60611,; USA.; The third variable domain (V3 domain) of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 contains a substantial number of positively charged amino acid residues. We previously demonstrated that mutation of basic amino acid residues at position 303, 306, 309, 313, and 325 in the V3 domain of
Direct interaction of complement factor H with the C1 domain of HIV type 1 glycoprotein 120.: AIDS Res Hum Retroviruses. 1995 May;11(5):577-88. Unique Identifier : AIDSLINE MED/96093893; Pinter C; Siccardi AG; Longhi R; Clivio A; Dipartimento di Biologia e Genetica per le Scienze Mediche,; Universita di Milano, Milan, Italy.; A protein that binds specifically to Env 105-119 (HEDIISLWDQSLKPC) was found in pools of normal human plasma when this peptide was used in affinity chromatography procedures. These samples represented the negative control in experiments aimed at the purification of putative human antibodies to the Env 105-119 region f
Seroreactivity of analogous antigenic epitopes in glycoprotein 120 expressed in HIV-1 subtypes A, B, C, and D.: AIDS Res Hum Retroviruses. 1995 May;11(5):589-96. Unique Identifier : AIDSLINE MED/96093894; Pestano GA; Hosford KS; Spira AI; Riley J; Xie JM; Sewankambo N; Brown L; Ho DD; Boto WM; Department of Biology, City College of the City University of New; York, New York 10031, USA.; This article describes the impact of sequence variation on the distribution and seroreactivity of linear antigenic epitopes in gp120 encoded in new Ugandan HIV-1 clones from subtypes A, C, and D, and in North American clones from the B subtype. A region of the env gene encoding the C2 to V5 domains was PCR amplified f
Characterization of HIV type 1 from Romanian children: lack of correlation between V3 loop amino acid sequence and syncytium formation in MT-2 cells.: AIDS Res Hum Retroviruses. 1995 May;11(5):597-603. Unique Identifier : AIDSLINE GENBANK/X77987; Holm-Hansen C; Grothues D; Rustad S; Rosok B; Pascu FR; Asjo B; Centre for International Health, University of Bergen, Norway.; The biological properties and amino acid sequences of the third variable domain (V3 loop and flanking regions) of the env region of 34 HIV-1 isolates obtained from Romanian children were analyzed. Unambiguous nucleic acid sequences were obtained from 31 isolates. The derived V3 amino acid sequences were highly homolog
Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela.: AIDS Res Hum Retroviruses. 1995 May;11(5):605-16. Unique Identifier : AIDSLINE GENBANK/U16779; Quinones-Mateu ME; Dopazo J; Este JA; Rota TR; Domingo E; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM),; Universidad Autonoma de Madrid, Cantoblanco, Spain.; Eight HIV-1 isolates from Venezuela have been characterized by nucleotide sequencing of the entire reverse transcriptase (RT)- and surface glycoprotein (gp 120)-coding regions. Average mutant frequencies were 2.5 x 10(-2) substitutions per nucleotide (s/nt) for the RT-coding reg
Intrapatient variability of the human immunodeficiency virus type 2 envelope V3 loop.: AIDS Res Hum Retroviruses. 1995 May;11(5):617-23. Unique Identifier : AIDSLINE GENBANK/U24388; Sankale JL; de la Tour RS; Renjifo B; Siby T; Mboup S; Marlink RG; Essex ME; Kanki PJ; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; Studies of HIV-2 infection have shown lower rates of sexual and perinatal transmission and a prolonged incubation period to AIDS as compared to HIV-1. To evaluate the role of genetic variation in HIV pathogenesis, we studied intrapatient variability in the V3 loop of the HIV-2 envelope gene over time in five seroposit
Nucleotide sequence and restriction fragment length polymorphism analysis of the long terminal repeat of human T cell leukemia virus type II.: AIDS Res Hum Retroviruses. 1995 May;11(5):625-36. Unique Identifier : AIDSLINE GENBANK/L37146; Eiraku N; Monken C; Kubo T; Zhu SW; Rios M; Bianco C; Hjelle B; Nagashima K; Hall WW; Department of Medical Virology, Rockefeller University, New York,; New York 10021, USA.; Molecular studies have demonstrated the existence of two major subtypes of human T cell leukemia virus type II: HTLV-IIa and HTLV-IIb. In attempts to further classify this family of viruses we have carried out nucleotide sequence and restriction fragment length polymorphism (RFLP) analysis of the long terminal repeat
Extraordinary high rate of HTLV type II seropositivity in intravenous drug abusers in south Vietnam.: AIDS Res Hum Retroviruses. 1995 May;11(5):637-45. Unique Identifier : AIDSLINE MED/96093899; Fukushima Y; Takahashi H; Hall WW; Nakasone T; Nakata S; Song P; Dinh Duc D; Hien B; Nguyen XQ; Ngoc Trinh T; et al; Laboratory of Immunology, AIDS Research Center, National; Institute of Health, Tokyo, Japan.; Serum specimens (n = 1899) were assayed for infections with HTLV-I, HTLV-II, and HIV-1 in seven classified groups of normal healthy controls, children, pregnant women, prostitutes, intravenous drug abusers, patients under going hemodialysis, and hemophiliacs in South and North Vietnam
Presence of the widespread subtype of HTLV-I in South Africa.: AIDS Res Hum Retroviruses. 1995 May;11(5):645-7. Unique Identifier : AIDSLINE MED/96093900; Yamashita M; Takehisa J; Miura T; Ido E; Becker WB; Robson BA; Becker ML; Hayami M; Laboratory of Pathogenic Virus, Institute for Virus Research,; Kyoto University, Japan.
Analysis of HTLV-I Env gene sequence from an Italian polytransfused patient: evidence for a Zairian HTLV-I in Sicily.: AIDS Res Hum Retroviruses. 1995 May;11(5):649-51. Unique Identifier : AIDSLINE MED/96093901; Boeri E; Abecasis C; Varnier OE; Franchini G; Laboratorio di Virologia, Centro S. Luigi, Ospedale San; Raffaelle, Via Stamira d'Ancona, Milano, Italy.
HIV-1 gp120 sequences from a doubly infected drug user.: AIDS Res Hum Retroviruses. 1995 May;11(5):653-5. Unique Identifier : AIDSLINE GENBANK/U20677; Sala M; Pelletier E; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.
Identification of HIV-1 subtype G from Uganda.: AIDS Res Hum Retroviruses. 1995 May;11(5):657-9. Unique Identifier : AIDSLINE GENBANK/U22010; Kaleebu P; Bobkov A; Cheingsong-Popov R; Bieniasz P; Garaev M; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; St. Mary's Hospital Medical School, London, UK.
Molecular cloning and characterization of a TAR-binding nuclear factor from T cells.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):663-9. Unique Identifier : AIDSLINE GENBANK/L22453; Reddy TR; Suhasini M; Rappaport J; Looney DJ; Kraus G; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; The TAt protein of the human immunodeficiency virus type 1 (HIV-1) activates the expression of viral mRNA through a cis-acting element in the LTR termed TAR. TAR RNA forms a stable stem-loop structure. Mutagenesis studies indicate that the stem structure, the primary sequence of the loop, and three unpaired bases in t
Resistance of HIV type 1 to proteinase inhibitor Ro 31-8959.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):671-6. Unique Identifier : AIDSLINE MED/96078227; Eberle J; Bechowsky B; Rose D; Hauser U; von der Helm K; Gurtler L; Nitschko H; Max von Pettenkofer Institute, University of Munich, Germany.; During replication of human immunodeficiency virus type 1 (HIV-1), proteolytic cleavage of Gag and Gag-Pol precursor proteins into different functional protein subunits is catalyzed by the viral proteinase, and this enzyme is the target of the antiviral proteinase inhibitor, Ro 31-8959. We investigated in vitro which
Antivirals that target the amino-terminal domain of HIV type 1 glycoprotein 41.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):677-86. Unique Identifier : AIDSLINE MED/96078228; Gordon LM; Waring AJ; Curtain CC; Kirkpatrick A; Leung C; Faull K; Mobley PW; Department of Pediatrics, Drew University-King Medical; Center/UCLA 90059, USA.; Functional and structural studies were made to assess whether a class of antiviral agents targets the N-terminal domain of the glycoprotein 41,000 (gp41) of human immunodeficiency virus type 1 (HIV-1). Previous experiments have shown that the amino-terminal peptide (FP-I; 23 amino acids, residues 519-541) of HIV-1 gp4
Multifaceted consequences of anti-gp41 monoclonal antibody 2F5 binding to HIV type 1 virions.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):687-96. Unique Identifier : AIDSLINE MED/96078229; Neurath AR; Strick N; Lin K; Jiang S; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021, USA.; A human monoclonal antibody (MAb) (2F5) neutralizing a variety of laboratory strains and clinical isolates of the human immunodeficiency virus type 1 (HIV-1) and binding to an epitope of the envelope glycoprotein gp41 encompassing the amino acid sequence ELDKWA has been described (Muster T et al., J Virol 1993;67:6642
Syncytium formation in cultured human lymphoid tissue: fusion of implanted HIV glycoprotein 120/41-expressing cells with native CD4+ cells.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):697-704. Unique Identifier : AIDSLINE MED/96078230; Margolis LB; Glushakova S; Baibakov B; Zimmerberg J; Laboratory of Theoretical and Physical Biology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.; While glycoprotein gp120/41 clearly causes HIV-infected cells to form syncytia in monolayers and in suspension, there is unfortunately scant knowledge on syncytium formation in tissues. We implanted gp120/41-expressing cells labeled with fluorescent particles inside blocks of human lymphoid tissue kept in long-term hi
Membrane-interactive phospholipids inhibit HIV type 1-induced cell fusion and surface gp160/gp120 binding to monoclonal antibody.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):705-12. Unique Identifier : AIDSLINE MED/96078231; Krugner-Higby L; Goff D; Edwards T; Iyer N; Neufeld J; Kute T; Morris-Natschke S; Ishaq K; Piantadosi C; Kucera LS; Department of Comparative Medicine, Wake Forest University; Medical Center, Winston-Salem, North Carolina 27157-1064, USA.; Membrane-interactive phospholipids (PLs), previously evaluated for activity against HIV-1 in vitro, are known to affect late steps in viral replication. Studies were done to determine the effects of PL analogs on post-translational processing of HIV-1 proteins, binding of viral surface gp160/gp120 to CD4 receptor, and
Altered constitutive and stress-regulated heat shock protein 27 expression in HIV type 1-infected cell lines.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):713-7. Unique Identifier : AIDSLINE MED/96078232; Brenner BG; Tao Y; Pearson E; Remer I; Wainberg MA; McGill AIDS Centre, Lady Davis Institute of the Sir Mortimer B.; Davis Jewish General Hospital, Montreal, Quebec, Canada.
Local synthesis of IgG antibodies to HIV within the female and male genital tracts during asymptomatic and pre-AIDS stages of HIV infection.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):719-29. Unique Identifier : AIDSLINE MED/96078233; Belec L; Tevi-Benissan C; Lu XS; Prazuck T; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.; Paired sera and cervicovaginal secretions or seminal fluids, obtained from HIV-1-infected, clinically asymptomatic women (n = 41) and men (n = 12), were investigated in order to test the hypothesis of a local synthesis of IgG to HIV in the female and male reproductive tracts. Anti-gp41 + p24 IgG was evaluated by an Ig
In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):731-40. Unique Identifier : AIDSLINE MED/96078234; Scadden DT; Levine JD; Bresnahan J; Gere J; McGrath J; Wang Z; Resta DJ; Young D; Hammer SM; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston, Massachusetts 02215, USA.; OBJECTIVE: To determine the safety, tolerance, and hematological and virological effects of the recombinant hematopoietic growth factor interleukin 3 (IL-3) in HIV-1-infected individuals with cytopenia. DESIGN AND METHODS: A phase I single-center trial was conducted with patients in cohorts of three receiving one of f
T cell blastogenic responses to Toxoplasma gondii trophozoites among HIV-infected patients.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):741-6. Unique Identifier : AIDSLINE MED/96078235; Carrega G; Canessa A; Argenta P; Cruciani M; Bassetti D; Department of Infectious Diseases, University of Genoa, Italy.; OBJECTIVE: To evaluate the cell-mediated immune response to Toxoplasma gondii (T. gondii) among HIV-infected patients. METHODS: Forty HIV-infected patients were studied. Of them, 35 had antibodies to T. gondii and 5 had not. Nine of 35 patients with detectable serum Toxoplasma antibodies were classified as group A1 (C
Defective natural killer cell cytotoxic activity in feline immunodeficiency virus-infected cats.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. Unique Identifier : AIDSLINE MED/96078236; Zaccaro L; Falcone ML; Silva S; Bigalli L; Cecchettini A; Giorgi F; Malvaldi G; Bendinelli M; Centro Retrovirus, Universita di Pisa, Italy.; Flow cytometry has been employed to study NK cell cytotoxic activity in cats infected with feline immunodeficiency virus. The results show that animals infected for 12 months or more have decreased levels of NK cell cytotoxic activity in their blood. The impairment could not be overcome by in vitro treatment of effect
Animal models recapitulate aspects of HIV/CNS disease.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):753-9. Unique Identifier : AIDSLINE MED/96078237; Vitkovic L; Stover E; Koslow SH; Division of Neuroscience and Behavioral Science, National; Institute of Mental Health, National Institutes of Health,; Rockville, Maryland 20857, USA.; Neurobehavioral and pathological data indicate that the central nervous system (CNS) becomes infected with HIV-1 soon after the virus enters the body. However, neuropathogenesis of HIV-1 infection is difficult to investigate because the brain parenchyma is not accessible to sampling during the course of AIDS. The seco
Multiple enhancer motifs in HIV type 1 strains from Ethiopia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):761-4. Unique Identifier : AIDSLINE GENBANK/U15071; Johansson B; Sherefa K; Sonnerborg A; Division of Clinical Virology, Huddinge University Hospital,; Karolinska Institutet, Sweden.
Partial nucleotide sequence analysis of the first case of human T lymphotropic virus type II from Australia.: AIDS Res Hum Retroviruses. 1995 Jun;11(6):765-7. Unique Identifier : AIDSLINE GENBANK/U25958; Bolton WV; Kenrick KG; Dwyer DE; Cunningham AL; Wylie BR; Saksena NK; Department of Virology and Biochemistry, NSW Red Cross Blood; Transfusion Service, Sydney, Australia.
National Cancer Institute 1995 annual meeting, Laboratory of Tumor Cell Biology, Bethesda, Maryland, August 27-September 2, 1995. Abstracts.: AIDS Res Hum Retroviruses. 1995 Aug;11 Suppl 1:S1-185. Unique Identifier : AIDSLINE MED/96071995
[Acalculous cholecystitis and intestinal cryptosporidiosis: frequent association in HIV patients]: Rev Esp Enferm Dig. 1995 Aug;87(8):593-6. Unique Identifier : AIDSLINE MED/96059227; Salvador Grande F; Saiz Monzon L; De la Torre P; Yuguero del Moral L; Lorenzo Gonzalez JF; Mijan de la Torre A; Five cases of acalculous cholecystitis associated with Cryptosporidium intestinal infection in HIV infected patients are reported. Clinical, Biological and Microbiological features as well as imaging studies are described. All the patients were males. Risk factors for HIV infection included previous I.V. drug abuse (3
Anaesthetic management of caesarean section in a patient with active recurrent genital herpes and AIDS-related dementia.: Br J Anaesth. 1995 Nov;75(5):639-41. Unique Identifier : AIDSLINE MED/96096028; Birnbach DJ; Bourlier RA; Choi R; Thys DM; Department of Anesthesiology, St Luke's-Roosevelt Hospital; Center, College of Physicians and Surgeons of Columbia; University, New York, New York 10019, USA.; We report the anaesthetic management of a pregnant patient with multiple manifestations of HIV infection who underwent Caesarean section. A 30-yr-old, HIV-positive, Haitian woman presented with acute psychosis at 28 weeks gestation. A diagnosis of HIV dementia complex was made and
HIV-related knowledge and risk behaviors of street youth in Belo Horizonte, Brazil. The Street Youth Study Group.: AIDS Educ Prev. 1995 Aug;7(4):287-97. Unique Identifier : AIDSLINE MED/96026583; Raffaelli M; Siqueira E; Payne-Merritt A; Campos R; Ude W; Greco M; Greco D; Ruff A; Halsey N; Universidade Federale de Minas Gerais, Belo Horizonte, Brazil.; Individual interviews were conducted with 379 youth who work and/or live on the streets of a large Brazilian city to assess HIV-related knowledge, sources of information, risk behaviors, and prevention beliefs and strategies. Respondents demonstrated high levels of factual knowledge about HIV transmission (84% correct
The perceived social context of AIDS: study of inner-city sexually transmitted disease clinic patients.: AIDS Educ Prev. 1995 Aug;7(4):298-307. Unique Identifier : AIDSLINE MED/96026584; Kalichman SC; Adair V; Somlai AM; Weir SS; Center for AIDS Intervention Research, Medical College of; Wisconsin, USA.; The present study investigated perceptions of AIDS as a social problem relative to 10 other problems in a sample of 194 inner-city sexually transmitted disease (STD) clinic patients. Within-subjects analyses showed that AIDS was viewed as a more serious problem than housing, alcoholism, and child care, while AIDS was
Reducing HIV needle risk behaviors among injection-drug users in the Midwest: an evaluation of the efficacy of standard and enhanced interventions.: AIDS Educ Prev. 1995 Aug;7(4):308-19. Unique Identifier : AIDSLINE MED/96026585; Siegal HA; Falck RS; Carlson RG; Wang J; Wright State University, School of Medicine, Substance Abuse; Intervention Programs, Dayton, Ohio 45401, USA.; This study compares the impact of a standard and an enhanced intervention on the needle-use behaviors reported by injection-drug users (IDUs) living in a low-seroprevalence area in the Midwest. Data on the drug- and needle-use practices of 381 IDUs completing a standard (n = 232) or an enhanced (n = 149) intervention
AIDS prevention with adolescents.: AIDS Educ Prev. 1995 Aug;7(4):320-36. Unique Identifier : AIDSLINE MED/96026586; Rotheram-Borus MJ; Mahler KA; Rosario M; Department of Psychiatry, University of California, Los Angeles,; USA.; Prevention of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) among adolescents is increasingly recognized as an important public health priority. Sexual risk acts associated with HIV/AIDS transmission (unprotected sexual intercourse with multiple partners of unknown serostatus) are ty
Early childhood differentials in mother-child AIDS-information interaction.: AIDS Educ Prev. 1995 Aug;7(4):337-54. Unique Identifier : AIDSLINE MED/96026587; Sly DF; Riehman K; Wu C; Eberstein I; Quadagno D; Kistner J; Center for the Study of Population, Florida State University,; Tallahassee 32306-4063, USA.; To date there have been no systematic inquiries into 1) the extent of parent-child AIDS interaction; or 2) the factors that influence whether young children and their parents talk about AIDS. In our sample, from a medium-sized Southern metropolitan area, 70 percent of mothers of children in the first, third, and fifth
HIV/AIDS knowledge among the U.S. population.: AIDS Educ Prev. 1995 Aug;7(4):355-72. Unique Identifier : AIDSLINE MED/96026588; Sweat MD; Levin M; Department of Sociology, Emory University, USA.; This analysis examines knowledge of HIV and AIDS among 71,370 persons interviewed in a national sample of the U.S. population. Factor analysis of 26 questions about HIV infection and AIDS identified four distinct dimensions of AIDS knowledge: 1) transmission mechanisms; 2) commonly known nontechnical information; 3) d
[Idiopathic CD4+ lymphocytopenia: a case report]: Ann Ital Med Int. 1995 Jul-Sep;10(3):188-92. Unique Identifier : AIDSLINE MED/96045855; Frassanito MA; Iodice G; Rizzi R; Dammacco F; Dipartimento di Scienze Biomediche ed Oncologia Umana,; Universita degli Studi di Bari.; We present the case of a 47-year-old patient who was seen for recurrent opportunistic infections. Immunophenotypic analyses disclosed severe reduction of CD4+ T cells. Repeated Elisa, Western blot and polymerase chain reaction tests for HIV were negative. The low CD4+ T lymphocyte count unaccompanied by increased CD8+
Inducible nitric oxide synthase in the central nervous system.: J Mol Neurosci. 1994-95;5(4):219-29. Unique Identifier : AIDSLINE MED/96101969; Sparrow JR; Department of Ophthalmology, Cornell University Medical College,; New York, NY 10021, USA.; There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial cells can contribute to nitric oxide-mediated neural-cell damage. Elucidation of iNOS inducing signals and mechanisms regulating its augmentation and suppression may have implicati
NF-kappa B site-mediated negative regulation of the HIV-1 promoter by CCAAT/enhancer binding proteins in brain-derived cells.: J Mol Neurosci. 1994-95;5(4):241-58. Unique Identifier : AIDSLINE MED/96101971; Mondal D; Alam J; Prakash O; Department of Molecular Oncology, Alton Ochsner Medical; Foundation, New Orleans, LA 70121, USA.; Several transcription regulatory elements that interact with cellular DNA-binding proteins have been identified in the HIV-1 long terminal repeat (LTR). We have identified two sequence motifs in the U3 region of the LTR that are similar to the consensus 9-bp DNA-binding element of the CCAAT/enhancer-binding protein (C
Tumor necrosis factor-alpha in children with human immunodeficiency virus infection [editorial]: Pediatr Hematol Oncol. 1995 Jul-Aug;12(4):v-ix. Unique Identifier : AIDSLINE MED/96068070; Levy Y; Danon YL
AIDS focus. The great dilemma.: Nurs Stand. 1995 Sep 27-Oct 3;10(1):50-3. Unique Identifier : AIDSLINE MED/96051801; Irvin S
AIDS focus. Food for thought.: Nurs Stand. 1995 Sep 27-Oct 3;10(1):54-6. Unique Identifier : AIDSLINE MED/96051802; Stevenson-Bryan E
Adherence of Malassezia isolates to human keratinocytes in vitro--a study of HIV-positive patients with seborrhoeic dermatitis.: Br J Dermatol. 1995 Oct;133(4):537-41. Unique Identifier : AIDSLINE MED/96096851; Schechtman RC; Midgley G; Bingham JS; Hay RJ; Medical Mycology Department, St John's Institute of Dermatology,; St Thomas' Hospital, London, U.K.; Adherence of Malassezia yeast cells to human keratinocytes was assessed by a novel technique using double-sided Sellotape. Although adherence using double-sided Sellotape is still merely a model for in vivo adherence, it approximates to the conditions found on the skin surface. There were no differences in adhesive pr
Detection of Epstein-Barr virus in cutaneous and lymph nodal anaplastic large cell lymphomas (Ki-1+).: Br J Dermatol. 1995 Oct;133(4):542-6. Unique Identifier : AIDSLINE MED/96096852; Peris K; Niedermeyer H; Chimenti S; Radaskiewicz T; Kerl H; Hoefler H; Department of Dermatology, Universities of L'Aquila, Italy.; Epstein-Barr virus (EBV) is a gamma DNA herpes virus which is thought to play a part in the pathogenesis of some non-Hodgkin s lymphomas in individuals with or without immunodeficiency. We investigated 16 lymph nodal and 12 cutaneous anaplastic large cell lymphomas (ALCLs) (Ki-1+), all of which were in patients withou
Protracted cutaneous disorders in association with low CD4+ lymphocyte counts.: Br J Dermatol. 1995 Oct;133(4):625-9. Unique Identifier : AIDSLINE MED/96096868; Kurwa HA; Marks R; Department of Dermatology, University of Wales College of; Medicine, Heath Park, Cardiff, U.K.; We report two patients with skin disorders usually associated with severe immunosuppression, who had low CD4+ lymphocyte counts but normal immunoglobulin levels. The patients were HIV negative, and had CD4+ lymphocyte counts just above 300/mm3, but they presented with cutaneous manifestations of profound immunodeficie
Primary cutaneous cryptococcosis in an immunocompromized pigeon keeper.: Br J Dermatol. 1995 Oct;133(4):650-2. Unique Identifier : AIDSLINE MED/96096875; Goonetilleke AK; Krause K; Slater DN; Dev D; Wood ML; Basran GS; Department of Respiratory Medicine, Rotherham General Hospitals; NHS Trust, U.K.
Association of changes in monocyte antigen presentation and cytokine production in haemophilic boys with treatment and blood-borne virus infection.: Br J Haematol. 1995 Sep;91(1):191-6. Unique Identifier : AIDSLINE MED/96070648; Pasi KJ; Evans JA; Wadhwa M; Thorpe R; Hill FG; Children's Hospital, Ladywood, Birmingham.; Aspects of monocyte function (antigen presentation and cytokine production (e.g. IL-1, IL-6) have been studied in a normal control population and three groups of haemophilic boys: group 1 HIV and HCV seronegative and treated only with a single heat-treated factor VIII (FVIII) concentrate; group 2 HIV seronegative but
Evidence for the aetiological role of blood-borne virus infections in causing reduced lectin-induced T-cell proliferation in haemophilic boys.: Br J Haematol. 1995 Sep;91(1):197-202. Unique Identifier : AIDSLINE MED/96070649; Evans JA; Pasi KJ; Hill FG; Department of Haematology, Children's Hospital, Ladywood,; Birmingham.; T-lymphocyte function, as expressed by polyclonal proliferation to lectin mitogens phytohaemagglutinin and concanavalin A, has been studied in a normal control population and three groups of haemophilic boys: group 1, HIV and HCV seronegative and treated only with a single heat-treated factor VIII (FVIII) concentrate;
Management of persistent B19 parvovirus infection in AIDS.: Br J Haematol. 1995 Sep;91(1):90-2. Unique Identifier : AIDSLINE MED/96070630; Ramratnam B; Gollerkeri A; Schiffman FJ; Rintels P; Flanigan TP; Department of Medicine, Miriam Hospital, Brown University School; of Medicine, Providence, Rhode Island, USA.; An HIV+ 26-year-old white man with a CD4 count of 0.06 x 10(9)/l was found to have red blood cell aplasia secondary to B19 parvovirus infection. Regular infusions of intravenous immunoglobulin (IVIG) were begun and resulted in marked reticulocytosis and correction of anaemia. The patient has been followed for over 4 y
Diagnosis of HIV infection from bloodstains by PCR. A further marker for identification.: Int J Legal Med. 1995;107(6):296-300. Unique Identifier : AIDSLINE MED/96022709; Giorgetti R; Rassu M; Tagliabracci A; Franchin E; Palu G; Ferrara SD; Istituto di Medicina Legale dell'Universita di Padova, Italy.; The forensic usefulness of the detection of HIV infection in bloodstains is linked to the increasing spread of HIV infection and the consequent rise in the number of forensic cases involving HIV-positive subjects. This study was designed to detect HIV infection in bloodstains of various ages obtained from HIV-positive
A simple and rapid flow cytometric method to measure lymphocyte activation in HIV+ subjects. Diminished response to pokeweed mitogen in early disease.: Anal Cell Pathol. 1995 Jun;8(4):345-55. Unique Identifier : AIDSLINE MED/96082377; Jagers E; De Brabander M; Baisier A; De Cree J; Verhaegen H; Verbiest W; Stoffels P; Clinical Research Unit St. Bartholomeus, Jan Palfijn Hospital,; Merksem, Belgium.; It was our objective to investigate the effect of asymptomatic infection with HIV on the expression of lymphocyte activation markers after stimulation with mitogens. Whole blood cultures were made of HIV+ and HIV- subjects (29 asymptomatic HIV-1-infected subjects and 33 apparently healthy normal volunteers). At variou
Th1 and Th2 help for B cells: differential capacity for induction of autonomous responsiveness to IL-2.: Int Immunol. 1995 Jun;7(6):1021-7. Unique Identifier : AIDSLINE MED/96082369; Poudrier J; Owens T; Department of Medicine, McGill University, Montreal, Quebec,; Canada.; Sustained interaction with Th1 cells has been shown to induce IL-2 responsiveness by murine B cells. This is equivalently dependent on CD40, CD54/ICAM-1 and MHC II ligation, and co-cross-linking of CD54 and MHC II in the presence of IL-5 up-regulates a functional IL-2R
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice.: Int Immunol. 1995 Jun;7(6):975-84. Unique Identifier : AIDSLINE MED/96082364; Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139, USA.; We have bred to homozygosity gene disruptions for the transporter associated with antigen processing 1 (TAP1) and beta 2-microglobulin (beta 2m), each of which plays a distinct role in providing class I MHC subunits. Surface expression of H-2Kb or Db on cells derived from TAP1/beta 2m -/- mice was undetectable by immu
A peptide from the heptad repeat of human immunodeficiency virus gp41 shows both membrane binding and coiled-coil formation.: Biochemistry. 1995 Oct 17;34(41):13390-7. Unique Identifier : AIDSLINE MED/96027453; Rabenstein M; Shin YK; Department of Chemistry, University of California, Berkeley; 94720, USA.; The envelope glycoprotein gp41 from human immunodeficiency virus type 1 (HIV-1) is involved in membrane fusion and virus entry. It contains a functionally important leucine zipper-like heptad repeat region (residues 553-590). To investigate the solution structure and membrane-binding properties of this region, cystein
A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein.: Biochemistry. 1995 Nov 21;34(46):14955-62. Unique Identifier : AIDSLINE MED/96072732; Blacklow SC; Lu M; Kim PS; Howard Hughes Medical Institute, Whitehead Institute for; Biomedical Research, Department of Biology, Massachusetts; Institute of Technology, Cambridge 02142, USA.; Previous attempts to define the oligomeric state of the HIV and SIV envelope glycoproteins have yielded conflicting results. We have produced in Escherichia coli a recombinant model for the ectodomain of the SIV envelope protein gp41 and have identified a small, trimeric subdomain by proteolytic digestion of this gp41
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.: Biochemistry. 1995 Nov 21;34(46):15111-22. Unique Identifier : AIDSLINE MED/96072749; Mazumder A; Gazit A; Levitzki A; Nicklaus M; Yung J; Kohlhagen G; Pommier Y; Laboratories of Molecular Pharmacology and Medicinal Chemistry,; National Cancer Institute, Bethesda, Maryland 20892, USA.; Efficient replication of HIV-1 requires establishment of the proviral state, i.e., the integration of a DNA copy of the viral genome, synthesized by reverse transcriptase, into a chromosome of the host cell. Integration is catalyzed by the viral integrase protein. We have previously reported that phenolic moieties in
Female prostitutes in south London: use of heroin, cocaine and alcohol, and their relationship to health risk behaviours.: AIDS Care. 1995;7(3):253-60. Unique Identifier : AIDSLINE MED/96067995; Gossop M; Powis B; Griffiths P; Strang J; Drug Transitions Project, National Addiction Centre, Maudsley; Hospital, London, UK.; The present study looks at the association between drug and alcohol use and sexual risk behaviours in a sample of 51 women who were currently working as prostitutes and also currently using opiates and/or stimulants. Most women reported regularly using condoms with clients but a substantial minority sometimes had unpr
Unconventional conceptions and HIV.: AIDS Care. 1995;7(3):261-76. Unique Identifier : AIDSLINE MED/96067996; Macaulay L; Kitzinger J; Green G; Wight D; Medical Research Council Medical Sociology Unit, Glasgow, UK.; The condom is widely recommended as the principal method for preventing HIV transmission, but such advice obviously does not apply to women who are seeking to become pregnant. In this sense, safer sex is incompatible with reproduction. Existing research into HIV transmission has examined the choices made by those wi
Risky heterosexual practices amongst women over 30: gender, power and long term relationships.: AIDS Care. 1995;7(3):277-93. Unique Identifier : AIDSLINE MED/96067997; Maxwell C; Boyle M; Psychology Department, Claybury Hospital, Woodford Bridge, Essex,; UK.; Statistics suggest that older and younger people are about equally at risk for HIV infection, yet existing research on heterosexuality and safer sexual practices has tended to focus on people under the age of 25. The present qualitative study investigates risk behaviours and the practice of safer sex in older populati
Perceived function of and barriers to condom use in Arusha and Kilimanjaro regions of Tanzania.: AIDS Care. 1995;7(3):295-305. Unique Identifier : AIDSLINE MED/96067998; Mnyika KS; Kvale G; Klepp KI; Department of Epidemiology & Biostatistics, Muhimbili University; College of Health Sciences, Dar es Salaam, Tanzania.; This paper presents data from a population-based survey which assessed perceived function of and barriers to condom use among the adult population aged 15-54 years in the Arusha and Kilimanjaro regions in northern Tanzania . A structured questionnaire was used in data collection.
Reliance by gay men and intravenous drug users on friends and family for AIDS-related care.: AIDS Care. 1995;7(3):307-19. Unique Identifier : AIDSLINE MED/96067999; Johnston D; Stall R; Smith K; Joint Program in Medical Anthropology, University of California,; San Francisco, USA.; A group of gay-identified men (n = 81) and intravenous drug users (n = 88) diagnosed with AIDS in San Francisco were interviewed regarding their use of friends and family to meet their care needs. Analytic of quantitative data revealed that gay men relied more than did IDUs on friends for care. Neither group relied pr
In-patient care for symptomatic, HIV-infected persons: a longitudinal study of hospitalizations, in-patient drug use, and related costs.: AIDS Care. 1995;7(3):321-36. Unique Identifier : AIDSLINE MED/96068000; Dijkgraaf MG; Luijben AH; Jager JC; Schrijvers AJ; Borleffs JC; Department of Internal Medicine, University Hospital Utrecht, The; Netherlands.; Patterns in the costs of hospital in-patient care and in-patient drug treatment of 121 symptomatic, HIV-infected patients are described for a university hospital between 1987 and 1991. Trend analyses have been performed on quarterly and yearly data using parametric and non-parametric statistical techniques. During the
Friends and lovers: needle sharing in young people in Western Australia.: AIDS Care. 1995;7(3):337-51. Unique Identifier : AIDSLINE MED/96068001; Loxley W; Ovenden C; National Centre for Research into the Prevention of Drug Abuse,; Curtin University of Technology, South Perth, Australia.; The Youth AIDS and Drugs (YAD) Study is a study of young people who inject drugs, and their risk of the transmission of HIV through needle sharing and/or unsafe sex. One hundred and five people, aged less than 21, 75% of whom were current or recent injectors, undertook in-depth interviews which were tape recorded, tra
Unmet needs for help among persons with AIDS.: AIDS Care. 1995;7(3):353-63. Unique Identifier : AIDSLINE MED/96068002; Smith MY; Rapkin BD; Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New; York, New York 10021, USA.; Current trends in AIDS care in the United States , including dehospitalization and improved outpatient treatment, may place many persons with AIDS (PWAs) at increased risk for having unmet need for help with daily living demands. Using interviews with 224 PWAs, we examined the prevalenc
Women and AIDS in Zambia: a review of the psychosocial factors implicated in the transmission of HIV.: AIDS Care. 1995;7(3):365-73. Unique Identifier : AIDSLINE MED/96068003; Campbell T; Kelly M; Hillingdon Hospital, Uxbridge, Middlesex, UK.; Women are at high risk for HIV infection in Zambia . There are several interrelated factors to account for this including the economic, cultural and educational status of women. This paper explores these factors and suggests that these factors need to be thoroughly understood before
Somatic care wanted by HIV-infected intravenous drug abusers: the patients' opinions and experiences.: AIDS Care. 1995;7(3):375-9. Unique Identifier : AIDSLINE MED/96068004; Krook A; Kastrup A; Lidman K; Mann C; Stymne A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; The somatic care of HIV-infected intravenous drug abusers (IVDUs) is often combined with many problems. The addict is often an unpopular patient, but society must assume responsibility for him or her and it is important to solve care problems in an appropriate way. This study was undertaken in order to investigate wha
Guidelines for counselling adolescents with haemophilia and HIV infection and their families.: AIDS Care. 1995;7(3):381-9. Unique Identifier : AIDSLINE MED/96068005; Miller R; Social Worker/Family Therapist Haemophilia Centre, AIDS; Counselling Co-ordinator Royal Free Hampstead NHS Trust, London,; UK.; Adolescents, poised between childhood and adulthood, and their families have many challenges. It is timely to review what these are for those with haemophilia, HIV and HCV (hepatitis C) infection in the 1990s. All three conditions are life long, life threatening and incurable. The main dilemmas facing these families a
WHO Global AIDS Statistics.: AIDS Care. 1995;7(3):397-8. Unique Identifier : AIDSLINE MED/96068006
RevM10-mediated inhibition of HIV-1 replication in chronically infected T cells.: Hum Gene Ther. 1995 May;6(5):625-34. Unique Identifier : AIDSLINE MED/96078097; Escaich S; Kalfoglou C; Plavec I; Kaushal S; Mosca JD; Bohnlein E; Progenesys, Palo Alto, CA 94304, USA.; Two clinical regimens have been proposed for gene therapies of acquired immunodeficiency syndrome (AIDS): (i) Genetic modification of differentiated peripheral mononuclear cells ex vivo and (ii) gene delivery into hematopoietic stem/progenitor cells ex vivo. Various antiviral strategies targeted at different molecular
An open label, phase I/II clinical trial to evaluate the safety and biological activity of HIV-IT (V) (HIV-1IIIBenv/rev retroviral vector) in HIV-1-infected subjects.: Hum Gene Ther. 1995 Jul;6(7):941-55. Unique Identifier : AIDSLINE MED/96097136; Haubrich R; McCutchan JA; Holdredge R; Heiner L; Merritt J; Merchant B; UCSD Treatment Center 92103-6325, USA.
Genetic modification of human peripheral blood lymphocytes with a transdominant negative form of Rev: safety and toxicity.: Hum Gene Ther. 1995 Aug;6(8):997-1004. Unique Identifier : AIDSLINE MED/96022631; Fox BA; Woffendin C; Yang ZY; San H; Ranga U; Gordon D; Osterholzer J; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; A transdominant mutant form of the rev gene, M10, confers resistance to infection by the human immunodeficiency virus (HIV) in vitro and is currently under investigation as a potential intervention in acquired immunodeficiency syndrome (AIDS). In this report, we examine three issues relevant to the safety of autologou
Buprenorphine for human immunovirus-positive opiate-dependent patients [letter]: Biol Psychiatry. 1995 Jul 15;38(2):135-6. Unique Identifier : AIDSLINE MED/96067984; Montoya ID; Umbricht A; Preston KL
Factors associated with the development of Pneumocystis carinii pneumonia in 5,025 European patients with AIDS. AIDS in Europe Study Group.: Clin Infect Dis. 1995 Jul;21(1):106-13. Unique Identifier : AIDSLINE MED/96065622; Lundgren JD; Barton SE; Lazzarin A; Danner S; Goebel FD; Pehrson P; Mulcahy F; Kosmidis J; Pedersen C; Phillips AN; Hvidovre Hospital, Denmark.; This study examined the factors associated with the development of a first episode of Pneumocystis carinii pneumonia (PCP) in 5,025 patients with AIDS, including 1,976 patients with primary PCP at the time of AIDS diagnosis and 635 with primary PCP occurring subsequently. Compared with untreated patients, patients tre
Failure of culture and polymerase chain reaction to detect human immunodeficiency virus (HIV) in seronegative steady sexual partners of HIV-infected individuals.: Clin Infect Dis. 1995 Jul;21(1):122-7. Unique Identifier : AIDSLINE MED/96065624; MacGregor RR; Dubin G; Frank I; Hodinka RL; Friedman HM; Department of Medicine, University of Pennsylvania Medical; Center, Philadelphia, USA.; Because of concern that steady sexual partners of patients infected with human immunodeficiency virus (HIV) may be infected despite negative results in tests for antibody to HIV, we studied 50 sexually active couples with discordant antibody results, assessing the agreement between these serological results and those
Sinonasal non-Hodgkin's lymphoma in patients infected with human immunodeficiency virus: report of three cases and review.: Clin Infect Dis. 1995 Jul;21(1):137-49. Unique Identifier : AIDSLINE MED/96065627; Pomilla PV; Morris AB; Jaworek A; Department of Medicine, Baystate Medical Center, Springfield,; Massachusetts 01199, USA.; Non-Hodgkin s lymphoma (NHL) is a frequent complication of human immunodeficiency virus (HIV) infection, but involvement of the sinonasal region has only rarely been reported. We report three cases of AIDS-associated sinonasal NHL that occurred at our institution and review eight cases that were reported in the litera
Pulmonary infection due to Leuconostoc species in a patient with AIDS [letter]: Clin Infect Dis. 1995 Jul;21(1):225-6. Unique Identifier : AIDSLINE MED/96065645; Ferrer S; de Miguel G; Domingo P; Pericas R; Prats G
Esophageal leishmaniasis in a patient infected with the human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1995 Jul;21(1):229-30. Unique Identifier : AIDSLINE MED/96065648; Gutierrez-Macias A; Alonso-Alonso JJ; Aguirre-Errasti C
Diarrhea associated with Vibrio fluvialis infection in a patient with AIDS [letter]: Clin Infect Dis. 1995 Jul;21(1):237-8. Unique Identifier : AIDSLINE MED/96065655; Hodge TW Jr; Levy CS; Smith MA
Fatal toxic epidermal necrolysis in patients with AIDS [letter; comment]: Clin Infect Dis. 1995 Jul;21(1):240. Unique Identifier : AIDSLINE MED/96065657; Caumes E; Gentilini M
Clinical and host differences between infections with the two varieties of Cryptococcus neoformans.: Clin Infect Dis. 1995 Jul;21(1):28-34; discussion 35-6. Unique Identifier : AIDSLINE MED/96065608; Speed B; Dunt D; Fairfield Hospital for Infectious Diseases, Victoria, Australia.; A population-based register of cases of cryptococcosis in patients treated in Victoria, Australia , over a 10-year period was established for studying the epidemiologic and clinical features of infection with Cryptococcus neoformans and its two varieties, gattii and neoformans. O
Multiorgan microsporidiosis: report of five cases and review.: Clin Infect Dis. 1995 Jul;21(1):37-44. Unique Identifier : AIDSLINE MED/96065609; Gunnarsson G; Hurlbut D; DeGirolami PC; Federman M; Wanke C; Department of Medicine, New England Deaconess Hospital, Harvard; Medical School, Boston, Massachusetts, USA.; We describe five cases and review 34 reported cases of multiorgan microsporidiosis . Most of the patients with multiorgan involvement have been adults with AIDS. Organs most commonly infected include the small intestine, urinary tract, biliary tree, and eye; involvement
Disseminated microsporidiosis due to Septata intestinalis in nine patients infected with the human immunodeficiency virus: response to therapy with albendazole.: Clin Infect Dis. 1995 Jul;21(1):70-6. Unique Identifier : AIDSLINE MED/96065615; Dore GJ; Marriott DJ; Hing MC; Harkness JL; Field AS; Department of Microbiology, St. Vincent's Hospital, Sydney,; Australia.; Disseminated microsporidiosis due to the newly described species Septata intestinalis in nine patients infected with human immunodeficiency virus is described. All patients were male homosexuals; the mean age was 41 years (range, 35-58 years). They were all severely im
Clinical manifestations and implications of coinfection with Mycobacterium kansasii and human immunodeficiency virus type 1.: Clin Infect Dis. 1995 Jul;21(1):77-85. Unique Identifier : AIDSLINE MED/96065616; Witzig RS; Fazal BA; Mera RM; Mushatt DM; Dejace PM; Greer DL; Hyslop NE Jr; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana 70112, USA.; We conducted a retrospective study to further elucidate the clinical presentations and prognosis of disease due to Mycobacterium kansasii in patients infected with human immunodeficiency virus (HIV). Forty-nine HIV-infected patients first had M. kansasii isolated at a mean CD4 cell count of 62/mm3 and at a mean interv
3D-QSAR of human immunodeficiency virus (I) protease inhibitors. III. Interpretation of CoMFA results.: Drug Des Discov. 1994 Jul;12(1):29-51. Unique Identifier : AIDSLINE MED/96062924; Opera TI; Waller CL; Marshall GR; Center for Molecular Design, Washington University School of; Medicine, St. Louis, MO 63130, USA.; Comparative Molecular Field Analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm (Cramer, R.D.; et al. (1988), J. Am. Chem. Soc., 110, 5959-5967), correlates variations in the (experimental) biological activity with 3D variance in the steric and electrostatic field of m
[Tetany caused by foscarnet in a female patient with acquired immunodeficiency syndrome (letter)]: An Med Interna. 1995 Jul;12(7):358-9. Unique Identifier : AIDSLINE MED/96059757; Vela Moreno J; Pascual Catalan A; Ramos Paesa C; Arazo Garces P; Aguirre Errasti JM
Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2.: Autoimmunity. 1995;20(4):247-58. Unique Identifier : AIDSLINE MED/96048134; Pearce RB; Formby B; Healy K; Peterson CM; Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.; T cells are involved in the induction and suppression of autoimmune diabetes in nonobese diabetic (NOD) mice. Because the incidence of diabetes is 13-fold greater in NOD/Smrf females, we searched for T cell phenotypes that showed sexual dimorphism and associated with diabetes in backcross segregants. The percentage of
Whole body hyperthermia associated with beta-carotene supplementation in patients with AIDS.: Biomed Pharmacother. 1995;49(5):263-5. Unique Identifier : AIDSLINE MED/96026495; Pontiggia P; Bianchi Santamaria A; Alonso K; Santamaria L; C Golgi Institute of General Pathology, Centro Tumori, University; of Pavia, Italy.; The objective of this work was to check possible additive beneficial effects of whole body hyperthermia (WBH) associated with beta-carotene (BC) supplementation in patients with AIDS. In a pilot study, 10 HIV positive patients, (8 with AIDS and 2 with AIDS related complex, ARC), after
Isolated renal mucormycosis: case report and review.: J Am Soc Nephrol. 1995 Jun;5(12):2014-9. Unique Identifier : AIDSLINE MED/96073207; Levy E; Bia MJ; Section of Nephrology, Yale University School of Medicine, New; Haven, CT, USA.; The 15th reported case of isolated renal mucormycosis (infection of the kidney with fungus of the order Mucorales, in the absence of infection elsewhere in the body) is presented. The patient was a 36-year-old human immunodeficiency virus-infected man, actively using iv drugs, who suffered 6 wk of flank pain and fever
[Detection of STLV-1 integration in DNA extracted from formalin-fixed and paraffin-embedded material from M. arctoides by polymerase chain reaction]: Biull Eksp Biol Med. 1995 Aug;120(8):214. Unique Identifier : AIDSLINE MED/96034094; Chikobava MG; Iakovlevai KA; Shattsel' G; Lapin BA
Factors associated with extrapulmonary tuberculosis as an AIDS-defining disease in Europe. The Coordinators of AIDS surveillance in Austria, Belgium, France, Germany, Italy, Portugal, Switzerland, United Kingdom and the city of Amsterdam.: Tuber Lung Dis. 1995 Aug;76(4):281-5. Unique Identifier : AIDSLINE MED/96048189; Schwoebel V; Delmas MC; Ancelle-Park RA; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.; SETTING: Western Europe: 8 countries and the city of Amsterdam. OBJECTIVE: To identify factors associated with extrapulmonary tuberculosis (EPTB) at AIDS diagnosis among adult AIDS patients. DESIGN: The proportion of AIDS case diagnosed between January 1988 and June 1992 with EPTB was analysed by age, gender, year of
Impact of the change from an injectable to a fully oral regimen on patient adherence to ambulatory tuberculosis treatment in Dar es Salaam, Tanzania.: Tuber Lung Dis. 1995 Aug;76(4):286-9. Unique Identifier : AIDSLINE MED/96048190; Chum HJ; Ilmolelian G; Rieder HL; Msangi J; Mwinyi N; Zwahlen M; Enarson DA; Ipuge YA; Tanzania National Tuberculosis/Leprosy Programme, Ministry of; Health, Dar es Salaam, Tanzania.; OBJECTIVE: To measure the impact on patient adherence to directly observed ambulatory tuberculosis treatment substituting an all-oral treatment regimen for a regimen containing streptomycin. METHODS: The expected and observed attendance of patients during the intensive phase of anti-tuberculosis treatment was measured
Identification of Mycobacterium intracellulare by a polymerase chain reaction using species-specific primers.: Tuber Lung Dis. 1995 Aug;76(4):330-5. Unique Identifier : AIDSLINE MED/96048197; Yamazaki T; Nakamura RM; Department of Bacteriology, National Institute of Health, Tokyo,; Japan.; SETTING: The polymerase chain reaction (PCR) is a rapid and specific method used to amplify a certain DNA fragment. It is applicable to rapid diagnosis of mycobacterial infections. By use of species-specific primers, it is possible to identify mycobacteria by PCR. In this study, a newly constructed primer was tested f
The epidemiology of Mycobacterium bovis infections in animals and man: a review.: Tuber Lung Dis. 1995 Aug;76 Suppl 1:1-46. Unique Identifier : AIDSLINE MED/96085694; O'Reilly LM; Daborn CJ; Veterinary Research Laboratory, Abbotstown, Castleknock, Ireland.; Tuberculosis is primarily a respiratory disease and transmission of infection within and between species is mainly by the airborne route. Mycobacterium bovis, the cause of bovine-type tuberculosis, has an exceptionally wide host range. Susceptible species include cattle, humans, non-human primates, goats, cats dogs, p
Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection.: Blood. 1995 Nov 15;86(10):3619-39. Unique Identifier : AIDSLINE MED/96068725; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255, USA.
Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells.: Blood. 1995 Nov 15;86(10):3705-14. Unique Identifier : AIDSLINE MED/96068735; Yanagida M; Fukamachi H; Ohgami K; Kuwaki T; Ishii H; Uzumaki H; Amano K; Tokiwa T; Mitsui H; Saito H; et al; Pharmaceutical Development Laboratory, Kirin Brewery Co, Ltd,; Gunma, Japan.; Although stem cell factor (SCF) has been identified as a critical cytokine for the development of human mast cells from their progenitors, the effects of other cytokines on human mast cells are less well understood. We examined the effects of several cytokines on the survival of human mast cells of 100% purity generat
The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.: Blood. 1995 Nov 15;86(10):3823-34. Unique Identifier : AIDSLINE MED/96068748; Zauli G; Gibellini D; Caputo A; Bassini A; Negrini M; Monne M; Mazzoni M; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; The regulatory Tat protein of human immunodeficiency virus type-1 (HIV-1) exerts a pleyotropic activity on the survival and proliferation of different cell types in culture. In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T
Immune responses to major histocompatibility complex homozygous lymphoid cells in murine F1 hybrid recipients: implications for transfusion-associated graft-versus-host disease.: Blood. 1995 Oct 15;86(8):3090-6. Unique Identifier : AIDSLINE MED/96017243; Fast LD; Valeri CR; Crowley JP; Department of Medicine, Rhode Island Hospital, Providence 02903,; USA.; Graft-versus-host disease (GVHD) is currently encountered after bone marrow transplantation and transfusion. GVHD associated with transfusion (TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient receiv
Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax.: Blood. 1995 Oct 15;86(8):3109-17. Unique Identifier : AIDSLINE MED/96017245; Tatewaki M; Yamaguchi K; Matsuoka M; Ishii T; Miyasaka M; Mori S; Takatsuki K; Watanabe T; Department of Pathology, University of Tokyo, Japan.; L-selectin is an adhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium. Upon cellular activation, expression of the L-selectin gene is downregulated at both the protein and mRNA levels. To understand the mechanism of leukemic cell infiltration into organs
Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity.: Blood. 1995 Nov 1;86(9):3287-94. Unique Identifier : AIDSLINE MED/96027492; Bernstein ZP; Porter MM; Gould M; Lipman B; Bluman EM; Stewart CC; Hewitt RG; Fyfe G; Poiesz B; Caligiuri MA; Department of Hematologic Oncology, Roswell Park Cancer; Institute, Buffalo, NY 14263, USA.; Ten adult patients with human immunodeficiency virus (HIV)-associated malignancies (five with lymphoma and five with Kaposi s Sarcoma) were treated with a daily subcutaneous injection of interleukin-2 ( IL-2 ) for 90 consecutive days in a phase I dose-escalation study. S
Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.: Blood. 1995 Nov 1;86(9):3479-86. Unique Identifier : AIDSLINE MED/96027516; Webb LM; Feldmann M; Kennedy Institute of Rheumatology, Sunley Division, Hammersmith,; London, UK.; CD28 is a major costimulatory signal receptor for T cells. We have used human naive CD4+ cells from cord blood to analyze the effect of the CD28/B7 costimulatory pathway on development of T helper (Th) subsets. We show that CD28 costimulation is critical for development of the Th2 cytokine-producing cells and that in
Hemoconcentration prior to serology testing in hemodiluted cadaver bone and tissue donors.: Clin Transplant. 1995 Aug;9(4):297-300. Unique Identifier : AIDSLINE MED/96039205; LeFor WM; Shires DL Jr; McGonigle AF; Shires DL 3rd; Transplantation Immunology Laboratory, LifeLink Foundation, Inc.,; Tampa, Florida, USA.; Concern about false negative serology tests for infectious diseases in hemodiluted cadaver donors resulted in issuance of new regulations and guidelines from the FDA and CDC. Bone or tissue from donors receiving > or = 4 units of blood, blood products, colloids or crystalloids within
Short-term male reproductive toxicity study with sulfasalazine in the rat.: Reprod Toxicol. 1995 May-Jun;9(3):315-26. Unique Identifier : AIDSLINE MED/96089907; Hoyt JA; Fisher LF; Swisher DK; Toxicology Research Laboratories, Eli Lilly and Company,; Greenfield, IN 46140, USA.; Sulfasalazine (2-hydroxy-5-[[4-[(2-pyridinylamino) sulfonyl] phenyl]azo]benzoic acid; SASP) was administered to rats in a short-term male reproductive toxicity study to further examine the utility of this grouping of techniques and to generate reference data with a substance that is known to cause reversible infertili
[Preliminary analysis of relationship between immunological changes and syndrome differentiation-typing in traditional Chinese medicine and prognosis with chronic idiopathic thrombocytopenic purpura]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):401-4. Unique Identifier : AIDSLINE MED/96041553; Yang YF; Zhou AX; Ma R; Dept. of Hematology, Xiyuan Hospital, China Academy of TCM,; Beijing.; In order to study the relationship between the basement immunological changes, TCM Syndrome Differentiation and prognosis, alkaline phosphates antialkaline phosphatase (APAAP) and ELISA assay were used to determine the T lymphocyte subsets, the platelet associated antibody (PAIgG, PAIgA, PAIgM) and plasma antiplatelet
[Relationship between syndrome types of TCM in lung neoplasm patients and peripheral T lymphocyte subsets, carcino-embryonic antigen]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):405-7. Unique Identifier : AIDSLINE MED/96041554; Fang CL; Zong WJ; Fan GR; Subei People Hospital, Yangzhou Medical College, Jiangsu.; Fifty-six cases with lung carcinoma were detected for peripheral blood T lymphocyte by direct staphylococcal protein A (SPA) bacterial rose ring for carcino-embryonic antigen (CEA) by radioimmunoassay, and the relationship between T lymphocyte. CEA and Syndrome of TCM was explored. The results were as follows:the valu
[A study on effect of qingwen granule in regulating immunological function in infantile respiratory viral infection]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1995 Jul;15(7):408-10. Unique Identifier : AIDSLINE MED/96041555; Zhang GC; Li ZH; Shen Q; Dept. of Pediatrics, Xijing Hospital, Fouth Military Medical; University, Xi'an.; To evaluate the effect of Qing-wen Granule (QWG) on immunological function, T lymphocyte subsets and interferon gamma(INF-gamma) expression cells in peripheral blood mononuclear cells, lymphocyte transformation rate and the level of salivary secretory IgA (sIgA) were determined by alkaline phosphatase antialkaline pho
Health education and safer sex.: Br J Nurs. 1995 Sep 28-Oct 11;4(17):999-1000, 1017-9. Unique Identifier : AIDSLINE MED/96051734; Winship G; Peachey A; Recent studies (e.g. Klee et al, 1991) of human immunodeficiency virus prevalence among drug users indicate that the greatest increase in transmission rates has been a result of sexual contact. This article examines safer sex health education and the development of a programme of education that aims to confront negati
Abnormalities of visual spatial attention in HIV infection and the HIV-associated dementia complex.: J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):325-33. Unique Identifier : AIDSLINE MED/96076004; Maruff P; Malone V; McArthur-Jackson C; Mulhall B; Benson E; Currie J; Neurophysiology and Neurovisual Research Unit, Mental Health; Research Institute of Victoria, Parkville, Australia.; Covert orienting of visuospatial attention (COVAT) was examined in 88 homosexual or bisexual men: 12 with mild HIV-associated dementia complex (ADC), 30 neurologically intact with AIDS (NI-AIDS), 23 asymptomatic HIV+ (HIV+ASX), and 23 HIV-negative control subjects. In mild ADC, COV
Global aspects of vaccination.: Int Arch Allergy Immunol. 1995 Dec;108(4):304-8. Unique Identifier : AIDSLINE MED/96071806; Ada G; Division of Cell Biology, John Curtin School of Medical Research,; Australian National University, Canberra, Australia.; The prospects for many children born in developing countries to reach adulthood has been transformed over the last 30 years by the activities of the Expanded Programme of Immunization (EPI) established by the World Health Organization (WHO) in 1974. By 1990, about 80% of children had b
Progress in AIDS vaccine development.: Int Arch Allergy Immunol. 1995 Dec;108(4):313-7. Unique Identifier : AIDSLINE MED/96071808; Johnston MI; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD 20892-7620,; USA.; Because of a unique combination of challenges facing human immunodeficiency virus vaccine developers, a number of traditional and novel vaccine designs are being evaluated essentially in parallel. Monomeric proteins, poxvirus vectors, peptides, and particle-based candidate vaccines have entered or will soon enter huma
Features of oral immunization.: Int Arch Allergy Immunol. 1995 Dec;108(4):334-9. Unique Identifier : AIDSLINE MED/96071812; Ruedl C; Wolf H; Institute for General and Experimental Pathology, Medical School,; University of Innsbruck, Austria.; In this review, we focus on some key areas concerning the unique properties of the mucosal immune system. They are: (1) the fact that the common mucosal immune system consists of different compartments; (2) the advantages of oral vaccination, which can be exploited to antigen-specific sIgA-mediated local immune respon
Conference on AIDS criticises inaction [news]: BMJ. 1995 Sep 23;311(7008):771. Unique Identifier : AIDSLINE MED/96061742; Willott S
Acquired immunodeficiency without HIV infection: epidemiology and clinical outcome in Italy. The Italian Study Group on non-HIV AIDS.: BMJ. 1995 Sep 23;311(7008):785-6. Unique Identifier : AIDSLINE MED/96061748; Rezza G; Pezzotti P; Aiuti F; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome.
Study shows two drugs are best for HIV infection [news]: BMJ. 1995 Sep 30;311(7009):827. Unique Identifier : AIDSLINE MED/96066558; Dillner L
Needle exchanges reduce HIV infection in US [news]: BMJ. 1995 Sep 30;311(7009):832. Unique Identifier : AIDSLINE MED/96066561; Roberts J
Decreasing HIV-1 seroprevalence in young adults in a rural Ugandan cohort.: BMJ. 1995 Sep 30;311(7009):833-6. Unique Identifier : AIDSLINE MED/96066563; Mulder D; Nunn A; Kamali A; Kengeya-Kayondo J; Medical Research Council Programme on AIDS in Uganda, Entebbe.; OBJECTIVE--To assess the trend in HIV-1 seroprevalence in an adult population in Uganda . DESIGN--An observational cohort study with four year follow up. SETTING--A cluster of 15 villages in rural Uganda. SUBJECTS--All residents of the 15 villages--about 10,000 people. MAIN OUTCOME
Tropical medicine for the 21st century.: BMJ. 1995 Sep 30;311(7009):860-2. Unique Identifier : AIDSLINE MED/96066572; De Cock KM; Lucas SB; Mabey D; Parry E; London School of Hygiene and Tropical Medicine.; The specialty of tropical medicine originated from the needs of the colonial era and is removed from many of the health care requirements of tropical countries today. Tropical medicine concentrates on parasitic diseases of warm climates, although other infections and diseases related to poverty rather than climate dom
Voluntary, named testing for HIV in a community based antenatal clinic: a pilot study.: BMJ. 1995 Oct 7;311(7010):928-31. Unique Identifier : AIDSLINE MED/96011317; Chrystie IL; Wolfe CD; Kennedy J; Zander L; Tilzey A; Banatvala JE; Department of Virology, United Medical and Dental Schools of; Guy's Hospital, London.; Despite the increasing advantages of identifying HIV infection in pregnant women, only some 12% of HIV positive women attending antenatal clinics in London have been identified by named testing. As virtually all antenatal care will be community based within the next two to three years, we assessed the problems of intr
Cuba: plenty of care, few condoms, no corruption.: BMJ. 1995 Oct 7;311(7010):935-7. Unique Identifier : AIDSLINE MED/96011319; Veeken H; Medecins Sans Frontieres, Amsterdam, Netherlands.; The health system in Cuba guarantees accessibility to the entire population, is free of charge, and covers the spectrum from vaccinations to sophisticated interventions. The results are impressive: Cuba s health figures are on a par with developed countries that have 20 times the bud
Australian doctors in confidentiality controversy [news]: BMJ. 1995 Oct 14;311(7011):971-2. Unique Identifier : AIDSLINE MED/96022004; Zinn C
Japan proposes settlement for tainted blood [news]: BMJ. 1995 Oct 21;311(7012):1044-5. Unique Identifier : AIDSLINE MED/96041830; Guest R
Australia launches third AIDS strategy [news]: BMJ. 1995 Oct 21;311(7012):1045-6. Unique Identifier : AIDSLINE MED/96041832; Zinn C
Prison rites: starting to inject inside.: BMJ. 1995 Oct 28;311(7013):1135-6. Unique Identifier : AIDSLINE MED/96048854; Gore SM; Bird AG; Ross AJ; MRC Biostatistics Unit, Cambridge.
The preparedness to share injecting equipment: an analysis using vignettes.: Addiction. 1995 Sep;90(9):1253-60. Unique Identifier : AIDSLINE MED/96019279; McKeganey N; Abel M; Taylor A; Frischer M; Goldberg D; Green S; Centre for Drug Misuse Research, University of Glasgow, UK.; This paper reports on the use of vignettes to study drug injectors preparedness to share injecting equipment. Separate vignettes referring to borrowing and passing on injecting equipment have been submitted to 505 injecting drug users in Glasgow. Injectors were asked to identify their own likely response in each of t
Special issue on AIDS.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):345-452. Unique Identifier : AIDSLINE MED/96059393
Pending problem of silent human immunodeficiency virus infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):345-50. Unique Identifier : AIDSLINE MED/96059392; Bentwich Z; Bar-Yehuda S; Nagai K; Wainberg MA; Kalinkovich A; Jehuda-Cohen T; Ruth Ben Ari Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University Medical School, Rehovot, Israel.; The problem of silent HIV infection is reviewed. Overall, the number of proven silent infection in several at-risk populations, including HIV exposed health-care workers, homosexuals, IV drug addicts and children born to HIV-infected mothers, has been very low. Contrary to these observations, we describe a very high p
Kinoids: the basis for anticytokine immunization and their use in HIV infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):351-6. Unique Identifier : AIDSLINE MED/96059394; Bizzini B; Achour A; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; HIV infection is characterized, at least in part, by the dysregulation of the cytokine network. Both IFN gamma and IFN alpha are occasionally overproduced. These cytokines could participate in the HIV-induced immunosuppression. To enable a HIV-infected organism to promote an immune reaction against the virus, the immu
Kaposi's sarcoma in patients infected with human virus (HIV): an overview.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):357-64. Unique Identifier : AIDSLINE MED/96059395; Hermans P; Clumeck N; Division of Infectious Diseases, St. Pierre University Hospital,; Brussels, Belgium.; The emergence of Kaposi s sarcoma (KS) among patients with HIV infection has raised a number of unsolved questions. The particular epidemiology and the etiology of KS remain unclear while both inflammatory cytokines and HIV-derived proteins appear to be involved in its pathogenesis as shown with the aid of in vitro KS
Internal transcriptional regulatory elements in HIV-1 and other retroviruses.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):365-9. Unique Identifier : AIDSLINE MED/96059396; Verdin E; Van Lint C; Picower Institute for Medical Research, Laboratory of Molecular; Virology, Manhasset, NY 11030, USA.; The transcriptional regulation of retroviruses plays an important role in their pathogenesis. Cis-acting elements have been identified in the long terminal repeat (LTR) at the 5 extremity of the integrated provirus. These elements determine the rate and the site of transcription initiation and consist of arrays of bi
Factors associated with progression to AIDS and mortality in a cohort of HIV-infected patients with hemophilia followed up since seroconversion.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):371-80. Unique Identifier : AIDSLINE MED/96059397; Santagostino E; Gringeri A; Cultraro D; Tradati F; Siracusano L; Marinoni A; Mannucci PM; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of; Internal Medicine, IRCCS Maggiore Hospital, University of Milan,; Italy.; Progression to AIDS and death were evaluated in 112 patients, 84 with hemophilia A and 28 with hemophilia B. Seroconversion period and age at seroconversion were similar in both groups. 36/112 patients died: 21/84 with hemophilia A (25%) and 15/28 (54%) with hemophilia B. Mean survival time was 11.7 years. The 10-year
Anti-alpha interferon immunization: safety and immunogenicity in asymptomatic HIV positive patients at high risk of disease progression.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):381-7. Unique Identifier : AIDSLINE MED/96059398; Gringeri A; Santagostino E; Mannucci PM; Siracusano L; Marinoni A; Criscuolo M; Carcagno M; Fall LS; M'Bika JP; Bizzini B; et al; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of; Internal Medicine, IRCCS Maggiore Hospital, Milan, Italy.; A randomized, placebo-controlled trial was designed to evaluate safety and immunogenicity of an anti-cytokine vaccine in high risk HIV-positive patients. This strategy was aimed to modulate the impaired cytokine regulation in AIDS. Twelve asymptomatic patients on antiretroviral therapy for at least 1 year and with CD4
Production in rabbits of high levels of anti-HIV-1 gp160 antibodies.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):389-93. Unique Identifier : AIDSLINE MED/96059399; Relyveld E; Bizzini B; Institut Pasteur, Unite des Vaccins Bacteriens,; Marnes-La-Coquette, France.; The production of anti-HIV-1 gp160 antibodies was obtained in rabbits given gp160 either in saline or adsorbed onto calcium phosphate. Immunization with gp160 in saline induced the formation of antibodies directed to the p18 protein, whereas the gp160 adsorbed onto calcium phosphate elicited antibodies recognizing the
HIV-1 soluble antigens induced CD8+ cytotoxic T-cell responses in an immunized individual.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):395-400. Unique Identifier : AIDSLINE MED/96059400; Achour A; Moukrim Z; Picard O; Bizzini B; Burny A; Zagury D; Universite Pierre et Marie Curie, Paris, France.; In an attempt to determine whether immunization of healthy HIV-1 seronegative individuals with a soluble gp160 candidate vaccine could induce an anti-HIV specific immune response, volunteers were immunized by two injections of a water-in-oil emulsion containing a mixture of gp160 antigen together with selected peptide
HIV-1 p17 synthetic peptide vaccine HGP-30: induction of immune response in human subjects and preliminary evidence of protection against HIV challenge in SCID mice.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):401-7. Unique Identifier : AIDSLINE MED/96059401; Sarin PS; Mora CA; Naylor PH; Markham R; Schwartz D; Kahn J; Heseltine P; Gazzard B; Youle M; Rios A; et al; Department of Biochemistry and Molecular Biology, George; Washington University Medical Center, Washington, D.C. 20037,; USA.; An HIV-1 p17 subunit vaccine, HGP-30, was evaluated in 38 HIV-1 seronegative individuals in phase I clinical trials in U.K. and U.S.A. The vaccine preparation induced cytotoxic T-cell (CTL) (11/25) and lymphocyte proliferation responses to KLH (19/20) and HGP-30/p17 (24/29) as well as antibody responses to HGP-30 (29/
Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):409-16. Unique Identifier : AIDSLINE MED/96059402; Fall LS; Chams V; Le Coq H; Fouchard M; M'Bika JP; Gringeri A; Santagostino E; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected pa
Impairment of circulating lactoferrin in HIV-1 infection.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):417-21. Unique Identifier : AIDSLINE MED/96059403; Defer MC; Dugas B; Picard O; Damais C; U313 INSERM, Centre de Recherche des Cordeliers, Paris, France.; Levels of plasma lactoferrin are decreased in HIV-1-infected patients in relation to the progression of the disease. Plasma lactoferrin concentrations were determined using a specific and sensitive enzyme immunoassay. 97 plasma were studied (22 asymptomatic, 45 symptomatic patients compared to 30 healthy controls) and
Which nutrient supplements for optimal HIV-1 production by cultured human lymphocytes?: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):423-30. Unique Identifier : AIDSLINE MED/96059404; Landureau JC; Achour A; Fouchard M; M'Bika JP; Maziere JC; Zagury D; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; Under standard conditions, all established cell-lines of HIV-1-infected lymphocytes are cultured in a medium containing a high percentage of serum. We have found that whilst partial or total serum depletion impedes their cell growth, it dramatically increases their virus production. Serial subcultures in serum-deplete
Contribution of alpha interferon (alpha IFN) to HIV-induced immunosuppression.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):431-7. Unique Identifier : AIDSLINE MED/96059405; Lachgar A; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; In the present investigation we have shown that PBLs taken from HIV-positive patients suppressed T-cell proliferation when cultured for at least 12 days. When infected In vitro with HIV-1, these cells become suppressive after 6 days. PBLs collected from seronegative individuals turned out to be non-suppressive even af
Cytotoxic T lymphocytes specific for the synthetic VEINCTR peptide, a sequence found within the Fas molecule and env gp120 in the blood of HIV-1 seropositive individuals.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):439-44. Unique Identifier : AIDSLINE MED/96059406; Moukrim Z; Achour A; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; We have previously identified a VEINCTR peptide common to both the Fasmolecule and HIV-1 gp120. Here we report the characterization in PBMCs from HIV-1-infected individuals of a CD8+ class I restricted CTL activity directed towards this peptide. The peptide is highly conserved in various HIV-1 strains, being located a
HIV-1 gp120/160 expressing cells upregulate HIV-1 LTR directed gene expression in a cell line transfected with HIV-1 LTR-reporter gene constructs.: Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):445-52. Unique Identifier : AIDSLINE MED/96059407; Merzouki A; Patel P; Cassol S; Ennaji M; Tailor P; Turcotte FR; O'Shaughnessy M; Arella M; Virology Research Center Institut Armand-Frappier, Laval, Quebec,; Canada.; The results described in this paper demonstrate that HIV-1 gp120 can upregulate gene expression directed by the HIV-1 LTR. Briefly, exposing responder CD4+CEM-T4 ID5 cells to stimulator CEMgp120/160 expressing cells (stably transfected with HIV-1 LTR-CAT and HIV-1 gp160, respectively) resulted in the increased synthes
Detection of HCV RNA by the asymmetric gap ligase chain reaction.: PCR Methods Appl. 1994 Oct;4(2):80-4. Unique Identifier : AIDSLINE GENBANK/M58335; Marshall RL; Laffler TG; Cerney MB; Sustachek JC; Kratochvil JD; Morgan RL; Abbott Laboratories, Molecular Diagnostics, Abott Park, Illinois; 60064, USA.; The ligase chain reaction (LCR) and the gap ligase chain reaction (gLCR) are exponential amplification techniques for the detection of DNA sequences in a sample. Both techniques depend on the enzyme, DNA ligase, to join adjacent probes annealed to a DNA molecule. However, DNA ligase joins DNA inefficiency on an RNA ta
Single-strand conformational polymorphism.: PCR Methods Appl. 1994 Dec;4(3):S137-40. Unique Identifier : AIDSLINE MED/96000013; Fujita K; Silver J; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA.
Quality assurance and use of PCR in clinical trials.: PCR Methods Appl. 1994 Dec;4(3):S141-9. Unique Identifier : AIDSLINE MED/96000014; Reichelderfer PS; Jackson JB; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; Qualitative and quantitative HIV-1 DNA and RNA PCR assays are proving to be useful in the diagnosis of HIV-1 infection in infants and in assessing the in vivo antiviral activity of new therapies and regimens in clinical trials. The use of these standardized commercial assays in conjunction with an external quality ass
Alteration of hairpin ribozyme specificity utilizing PCR.: PCR Methods Appl. 1994 Dec;4(3):139-44. Unique Identifier : AIDSLINE MED/96000001; DeGrandis P; Hampel A; Galasinski S; Borneman J; Siwkowski A; Altschuler M; Department of Biological Science, Northern Illinois University,; DeKalb 60115, USA.; We have developed a method by which a researcher can quickly alter the specificity of a trans hairpin ribozyme. Utilizing this PCR method, two oligonucleotides, and any target vector, new ribozyme template sequences can be generated without the synthesis of longer oligonucleotides. We have produced templates with alte
Genetic subtyping of human immunodeficiency virus using a heteroduplex mobility assay.: PCR Methods Appl. 1995 Apr;4(5):S202-16. Unique Identifier : AIDSLINE GENBANK/L22085; Delwart EL; Herring B; Rodrigo AG; Mullins JI; Department of Microbiology and Immunology, Stanford University; School of Medicine, California 94305-5402, USA.
Single-tube nested PCR with room-temperature-stable reagents.: PCR Methods Appl. 1995 Jun;4(6):376-9. Unique Identifier : AIDSLINE MED/96000081; Wolff C; Hornschemeyer D; Wolff D; Kleesiek K; Institut fur Laboratoriums- und Transfusionsmedizin, Herz- und; Diabeteszentrum Nordrhein-Westfalen, Universitatsklinik der; Ruhr-Universitat Bochum, Bad Oeynhausen, Germany.
Predictors of Taiwanese nurses' intention to care for patients who are HIV positive.: Clin Nurs Res. 1995 Nov;4(4):442-64. Unique Identifier : AIDSLINE MED/96051763; Tsai YF; Keller ML; The purpose of this research was to explore the knowledge of, attitudes toward, and intention to care for HIV-positive patients among 223 Taiwanese nurses. They worked in many different settings and had a variety of levels of exposure to HIV-positive patients. The findings of this research revealed that most Taiwanese
[A spatial structure model of the basic antigenic determinant of the human immunodeficiency virus type 1 gp120 protein]: Dokl Akad Nauk. 1995 Jun;342(4):543-5. Unique Identifier : AIDSLINE MED/96076046; Andrianov AM; Akhrem AA