The ascendancy--and the future--of combination antiretroviral and immunomodulatory therapies. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

The ascendancy--and the future--of combination antiretroviral and immunomodulatory therapies. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.

J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):20-5. Unique Identifier : AIDSLINE AIDS/96701852
Cooper DA; University of New South Wales, Sydney, Australia.

Abstract: There has been a recent demise in antiretroviral monotherapy and the ascendancy of combination therapy for HIV-infected patients. A few of the trials that established the change and a few that may contribute to the continuing evolution of antiretroviral therapy are briefly reviewed. The effect of antiretroviral therapy on the immune response and whether immunomodulators can be considered antiretroviral agents are explored. Finally, suggestions are provided on how medicine can move forward with the newly-developed agents and how clinical trial design might evolve in light of the extraordinary advances made in the past year.

Keywords: Adjuvants, Immunologic/*THERAPEUTIC USE Antiviral Agents/*THERAPEUTIC USE Clinical Trials HIV Infections/*DRUG THERAPY Human NEWSLETTER ARTICLE MEETING REPORT
961230
M96C1446

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