Five-drug or six-drug antiretroviral therapy--conversation with Steven Scheibel, M.D. [interview by John S. James] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

AIDS Treat News. 1996 Aug 23;(No 253):1-2. Unique Identifier : AIDSLINE AIDS/96701859
Scheibel S

Abstract: In an interview with AIDS Treatment News, Steven F. Scheibel, M.D. discusses the results of two small studies in San Francisco that reported good HIV suppression with regimens of five-drug and six-drug antiretroviral therapy. The studies included a clinical trial of 6 patients infected with HIV-1 within the past 6 months and an observational study of 15 patients with prolonged HIV infection. In both studies, patients were treated with a low-dose combination of AZT, ddI, ddC, and interferon-alpha, with most also taking a protease inhibitor. All of the recent seroconverters and many of the longer term patients achieved undetectable HIV RNA as measured by the Roche Ultradirect Monitor assay. Future research plans for Dr. Scheibel include the study of the HIV proviral DNA load and changes that occur with combination antiretroviral therapies.

Keywords: Antiviral Agents/*ADMINISTRATION & DOSAGE Drug Therapy, Combination HIV Infections/*DRUG THERAPY/VIROLOGY *HIV-1/ISOLATION & PURIF Human NEWSLETTER ARTICLE INTERVIEW
961230
M96C1439

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