1996

Phase I study of ex vivo anti-CD3-stimulated CD4+ T cells, interleukin-2 (IL-2) and cyclophosphamide (CTX) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1044 1996. Unique Identifier : AIDSLINE ICDB/196636044; Curti B; Ochoa A; Kopp W; Gause B; Janik J; Fenton R; Miller L; Holmlund J; Creekmore S; Sznol M; Longo D; CRB, NCI, Frederick, MD 21701; A prior CRB trial treated patients (pts) with anti-CD3-stimulated T cells, IL-2 and CTX. In vivo T-cell expansion was achieved, but responses were infrequent. Animal models showed that CD4+ T cells promoted greater antitumor effects than CD8+ or unselected T cells, and
The:mindscape of AIDS : dynamics of transmission.: Cape Town : Percept, 1992 viii, 103 p. : ill Unique Identifier : AIDSLINE CAT/9611934; Perkel AK
AIDS crossing borders : the spread of HIV among migrant Latinos.: Boulder, Colo. : Westview Press, 1996 x, 214 p. : ill Unique Identifier : AIDSLINE CAT/9613074; Mishra SI; Conner RF; Magana JR
AIDS, a family disease : initial guidelines. 1st ed.: Braamfontein : South African National Council for Child and Family Welfare, 1993 62 p Unique Identifier : AIDSLINE CAT/9612427
[Conocimientos sobre aspectos epidemiologicos del S.I.D.A. en los adolescentes gaditanos : grupo de estudio, epidemiologia pediatrica, Cadiz, 1992.]: Salud Cadiz : Escuela Universitaria de Ciencias de la Salud de la Universidad de Cadiz, 1993 104 p. : ill Unique Identifier : AIDSLINE CAT/9602725
[Consequences demographiques du sida en Abidjan : 1986-1992.]: Paris : Centre francais sur la population et le developpement, 1995 xxii, 198 p. : ill (Les etudes du Ceped, ISSN 0993-6157 ; no 10) Unique Identifier : AIDSLINE CAT/9608593; Garenne M
HIV funding watch. Vol. 1, no. 1 (Feb. 6, 1990)-: Austin, Tex. : Reprographics and Library Services Division, 1990- v Unique Identifier : AIDSLINE CAT/9425809
HIV/AIDS cross-reference directory for community educational materials.: [Falls Church, Va. : The Center], 1995 56 p Unique Identifier : AIDSLINE CAT/9612350
[Leben auf Zeit : ein Psychotherapiemanual fur den Umgang mit HIV/Aids und anderen lebensbedrohlichen Krankheiten.] 1. Aufl.: Bern ; Seattle : Verlag Hans Huber, 1996 218 p. : ill (Psychologie Praxis) Unique Identifier : AIDSLINE CAT/9608018; Husler G
[Seksualiteit in Nederland : seksueel gedrag, risico en preventie van AIDS.]: Amsterdam : Swets & Zeitlinger, c1991 263 p. : ill Unique Identifier : AIDSLINE CAT/9403888; Zessen Gv
AIDS and its applied homoeopathy.: Madras, India : Homoeo Vasam Publications, 1995 161 p. : ill Unique Identifier : AIDSLINE CAT/9614663; Muthukumar V
AIDS in the UK : the making of policy, 1981-1994.: New York : Oxford University Press, 1996 xiv, 389 p. : ill Unique Identifier : AIDSLINE CAT/9610150; Berridge V
[Boletim Pela VIDDA.]: Rio de Janeiro : Grupo Pela VIDDA, v Unique Identifier : AIDSLINE CAT/9440267
Meeting to Promote Condom Social Marketing for AIDS/STD Prevention : Yaounde, Cameroon, 2-5 November 1993.: Prevention [Geneva] : Global Programme on AIDS, World Health Organization, [1995] 7 p Unique Identifier : AIDSLINE CAT/9610985
Opportunistic fungal infections in AIDS patients : a clinician's handbook.: [United States?] : SynerMed, c1995 24 p. : ill Unique Identifier : AIDSLINE CAT/9611383
Preventing and mitigating AIDS in Sub-Saharan Africa : research and data priorities for the social and behavioral sciences.: Washington, D.C. : National Academy Press, 1996 xi, 356 p. : ill Unique Identifier : AIDSLINE CAT/9611480; Cohen B; Trussell J; Priorities for Arresting AIDS in Sub-Saharan Africa
Research on educational aspects of AIDS in Uganda : an inventory.: [Kampala] : Unicef ; [Entebbe, Uganda] : Republic of Uganda, The Ministry, [1991] 30 p Unique Identifier : AIDSLINE CAT/9610348; Kristiansen V
Socio-economic and occupational mortality differentials, 1980.: Budapest : Central Statistical Office, 1988- v (Studies in mortality differentials ; 4) Unique Identifier : AIDSLINE CAT/9611887; Varga A
Transfusion-associated AIDS.: Tucson, AZ : Lawyers & Judges Pub. Co., c1995 xv, 346 p. : forms Unique Identifier : AIDSLINE CAT/9608191; Jenner RK; Burgess SJ
[Visszaemlekezeseim.]: Debrecen : DOTE Rekori Hivatala, 1983 193 p. : ill., ports Unique Identifier : AIDSLINE CAT/9400849; Ladanyi J
The:sociology of HIV transmission.: London ; Thousand Oaks, Calif. : Sage Publications, 1995 ix, 158 p Unique Identifier : AIDSLINE CAT/9612727; Bloor M
AIDS and society.: Upper Saddle River, N.J. : Prentice Hall, c1996 xiv, 370 p. : ill., ports Unique Identifier : AIDSLINE CAT/9614323; Smith JM
AIDS : the politics and policy of disease.: Upper Saddle River, N.J. : Prentice Hall, c1996 viii, 152 p. : ill Unique Identifier : AIDSLINE CAT/9614316; Theodoulou SZ
Evaluation of local HIV service delivery : issues, approaches & strategies under Title I, the Ryan White Care Act : a meeting sponsored by Division of HIV Services and Office of Science & Epidemiology, Bureau of Health Resources Development, Health Resources and Services Administration.: [Rockville, Md.? : Health Resources & Services Administration, 1996] i, 52 p. : ill Unique Identifier : AIDSLINE CAT/9615499; Eilbert K
Grief and AIDS.: Chichester ; New York : Wiley, c1995 xi, 215 p Unique Identifier : AIDSLINE CAT/9612723; Sherr L
[Prevention du sida en milieu specialise.]: Ramonville Saint-Agne : Eres, c1996 175 p. : ill Unique Identifier : AIDSLINE CAT/9615445; Greacen T
Resource manual for support of dentists with HBV, HIV, TB and other infectious diseases.: Chicago, Ill. : The Council, 1995 iii, 63 p Unique Identifier : AIDSLINE CAT/9604741
Criteria for the medical care of children and adolescents with HIV infection.: [New York] : AIDS Institute, New York State Dept. of Health, [1995] xvii, 259 p Unique Identifier : AIDSLINE CAT/9615278
Designing new antiviral drugs for AIDS : HIV-1 protease and its inhibitors.: Austin : R.G. Landes, 1996 (Bioscience reports) Unique Identifier : AIDSLINE CAT/9615936; March D; Fairlie DP
Home care guide for HIV/AIDS : how to care for family and friends at home.: Philadelphia : American College of Physicians, c1995 Unique Identifier : AIDSLINE CAT/9616219; Houts PS
Program advisory : use of zidovudine (ZDV) to reduce perinatal HIV transmission in HRSA-funded programs.: [Washington, D.C.?] : U.S. Dept. of Health & Human Services, Public Health Service, Health Resources & Services Administration, [1995] ii, 30 p. : ill Unique Identifier : AIDSLINE CAT/9609368
HIV and AIDS newsletter. Vol. 1, #1-v. 3, #1.: [Calgary, Alta.] : The Society, [1990?-1992?] 3 v Unique Identifier : AIDSLINE CAT/9425865
HIV briefs.: Project [Darlinghurst, NSW?] : The Project, v Unique Identifier : AIDSLINE CAT/9425623
HIV herald : monthly magazine of the AFAO National Treatments Project.: Project Darlinghurst, NSW : The Project, v Unique Identifier : AIDSLINE CAT/9425575
HI:V frontline : a message to the mental health and health-care professionals who counsel people living with HIV. #1 (Apr. 1991)-: Prevention Studies San Francisco, Calif. : L. McKusick, 1991- v Unique Identifier : AIDSLINE CAT/9425632
AIDS and the ADA: physician liability for discriminatory nontreatment or referral of AIDS patients.: J Cardiovasc Manag. 1996 Jul-Aug;7(4):12, 14-5. Unique Identifier : AIDSLINE AHA/96364651; Hirsch WR
What to do about hives.: Contemp Pediatr. 1996 Aug;13(8):93-4. Unique Identifier : AIDSLINE HTA/96343729; Schmitt BD; General Consultative Services, Children's Hospital of Denver,; University of Colorado School of Medicine, USA.
Social context of HIV infection in Uganda.: Health Transit Rev. 1995;5 Suppl:1-26. Unique Identifier : AIDSLINE HTA/96364369; Adeokun LA; Twa-Twa J; Ssekiboobo A; Nalwadda R; Institute of Statistics and Applied Economics, Makerere; University, Kampala, Uganda.; Some of the important policy and research implications of accumulating HIV/AIDS data are being ignored because of the attraction of social science research focused on the multiple sexual mechanism of infection and transmission. Attention is drawn to the other policy and research issues relating to information on the
The effects of HIV and AIDS on fertility in East and Central Africa.: Health Transit Rev. 1995;5 Suppl:179-89. Unique Identifier : AIDSLINE HTA/96364372; Setel P; National Centre for Epidemiology and Population Health,; Australian National University.; Concern has been expressed about the fertility of people infected with HIV: the worry has been that on learning of their condition, HIV-affected individuals may attempt to accomplish unmet reproductive goals knowing that they will not live a normal life span. This article addresses the potential effects of AIDS on fer
Impact of AIDS on the family and mortality in Uganda.: Health Transit Rev. 1995;5 Suppl:191-200. Unique Identifier : AIDSLINE HTA/96364373; Mukiza-Gapere J; Ntozi JP; Department of Population Studies, Institute of Statistics and; Applied Economics, Makerere University.
Impact of AIDS on marriage patterns, customs and practices in Uganda.: Health Transit Rev. 1995;5 Suppl:201-8. Unique Identifier : AIDSLINE HTA/96364374; Mukiza-Gapere J; Ntozi JP; Department of Population Studies, Institute of Statistics and; Applied Economics, Makerere University.
Care for AIDS orphans in Uganda: findings from focus group discussions.: Health Transit Rev. 1995;5 Suppl:245-52. Unique Identifier : AIDSLINE HTA/96364375; Ntozi JP; Mukiza-Gapere J; Department of Population Studies, Institute of Statistics and; Applied Economics, Makerere University.
The declining HIV seroprevalence in Uganda: what evidence?: Health Transit Rev. 1995;5 Suppl:27-33. Unique Identifier : AIDSLINE HTA/96364370; Konde-Lule JK; Institute of Public Health, Makerere University, Kampala.
On second thought: a Canadian reflection. Informing after the fact: AIDS, confidentiality, and the duty to warn.: HEC Forum. 1996 Jul;8(4):212-20. Unique Identifier : AIDSLINE AHA/96360845; Flagel DC
AIDS--meeting the challenge of home care.: Caring. 1996 Aug;15(8):10-2. Unique Identifier : AIDSLINE AHA/96365104; Taylor E; Visiting Nurse Association of Washington, DC, USA.
Crossing cultural barriers to care for people with AIDS.: Caring. 1996 Aug;15(8):14-8. Unique Identifier : AIDSLINE AHA/96365105; Cuthbert-Allman C; Chausse M; Visiting Nurse Association of Boston, USA.; The delivery of high-quality home care to HIV/AIDS patients is often complicated by the cultural barriers present when caring for minority populations. Developing trust, listening skills, and a nonjudgmental approach are essential to providers who care for people of varied cultural backgrounds.
Creating partners in HIV care.: Caring. 1996 Aug;15(8):20-4. Unique Identifier : AIDSLINE AHA/96365106; Adams J; Founder of Home Care Companions, Inc, San Francisco, CA, USA.; Home care teams caring for people with AIDS often must depend on informal caregivers to help their patients. If the informal caregivers have better tools to help, patients are more likely to get the best care possible. This training program for care partners is a perfect way to provide those tools.
Pain management and psychosocial issues in HIV and AIDS.: Caring. 1996 Aug;15(8):26-35. Unique Identifier : AIDSLINE AHA/96365107; Breitbart W; Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Nutrition for in-home AIDS patients.: Caring. 1996 Aug;15(8):36-8. Unique Identifier : AIDSLINE AHA/96365108; Sachs KM; Visiting Nurse Association of Washington, DC, USA.; Early medical nutrition intervention with in-home AIDS patients can help prolong and improve the quality and quantity of their lives. Teaching the basics of good nutrition both early on as well as in the later stages of AIDS can save thousands of health care dollars through preventive care at home.
Pediatric AIDS program addresses whole families.: Caring. 1996 Aug;15(8):42-4. Unique Identifier : AIDSLINE AHA/96365109; Dobson AS; Clarke N; Visiting Nurse Association of South Central Connecticut, Inc.,; New Haven, USA.; Families of children with AIDS are often at risk for substance abuse, child neglect, and homelessness. Effective service delivery to the pediatric AIDS population requires a holistic, team-oriented approach for the whole family.
Needle exchange programs benefit the community.: Caring. 1996 Aug;15(8):46-7. Unique Identifier : AIDSLINE AHA/96365110; Whitteker WB; San Diego Clean Needle Exchange, CA, USA.; Needle exchange programs, illegal in many communities, provide HIV-prevention services to a hard-to-reach population--injection drug users (IDU). Reaching IDUs, who are among society s most at-risk members for HIV infection, protects the health of the community at large.
Passive hyperimmune therapy: buying time at what cost?: Caring. 1996 Aug;15(8):48-50. Unique Identifier : AIDSLINE AHA/96365111; Chavez C; Some AIDS physicians are now turning to passive hyperimmune therapy as an alternative to try to protect and rebuild AIDS patients ravaged immune systems. This is a labor-intensive and expensive treatment that raises many questions.
Home HIV tests: the need for regulation.: Caring. 1996 Aug;15(8):52-5. Unique Identifier : AIDSLINE AHA/96365112; Tamborlane TA; Kunz DA; Theodosia A. Tamborlane, P.C., Mountainside, NJ, USA.; In-home testing for HIV/AIDS will be available nationwide in early 1997. Because laws regulating these over-the-counter test kits vary widely from state to state, national uniform regulations are needed to safeguard the rights of consumers and to protect health care providers from professional liability.
HIV/AIDS resources on the Internet.: Caring. 1996 Aug;15(8):56-63. Unique Identifier : AIDSLINE AHA/96365113; Davis NA; National Association for Home Care, Washington, DC, USA.; Both HIV/AIDS patients and their caregivers can find a wealth of information about HIV and AIDS on the Internet, if they know where to look for it. Below is a guide to get both professionals and lay people started on their search for HIV/AIDS information.
Congress reauthorizes the Ryan White CARE (Comprehensive AIDS Resources Emergency) Act.: Caring. 1996 Aug;15(8):68-9. Unique Identifier : AIDSLINE AHA/96365114; Sokol EW
Finance a humane system of AIDS care.: Caring. 1996 Aug;15(8):7. Unique Identifier : AIDSLINE AHA/96365103
Cost effectiveness of antituberculosis interventions.: Pharmacoeconomics. 1995 Nov;8(5):385-99. Unique Identifier : AIDSLINE HTA/96275164; Castelo A; Mathiasi PA; Iunes R; Kritski AL; Dalcolmo M; Fiuza de Melo F; Drummond M; Universidade Federal de Sao Paulo, Brazil.; The treatment of tuberculosis (TB) is ranked as the most cost effective of all therapeutic programmes in terms of cost per year of life saved. Nevertheless, TB kills or debilitates more adults aged between 15 and 59 years than any other disease in the world; furthermore, about 2 to 4% of the burden of disease, 7% of a
The economic costs of caring for people with HIV infection and AIDS in England and Wales.: Pharmacoeconomics. 1996 Apr;9(4):332-40. Unique Identifier : AIDSLINE HTA/96321915; Petrou S; Dooley M; Whitaker L; Beck E; Kupek E; Wadsworth J; Miller D; Renton A; Academic Department of Public Health, St Mary's Hospital Medical; School, London, England.; The objectives of this study were firstly to estimate total lifetime care costs for an individual with HIV/AIDS, and secondly to estimate the total costs of caring people with HIV infection and AIDS in England and Wales between 1992 and 1997 inclusive. Questionnaires and monthly diaries were used to collate data on he
Economic analysis at the global level: a resource requirement model for HIV prevention in developing countries.: Health Policy. 1996 Oct;38(1):45-65. Unique Identifier : AIDSLINE AHA/96383676; Broomberg J; Soderlund N; Mills A; Monitor Company, Johannesburg, South Africa.; Agencies operating at the international level have a need for economic analysis to help develop global health policies and determine resource requirements to support their advocacy efforts. This paper presents work commissioned by the Global Programme on AIDS to estimate the total resource requirements of implementing
HIV-preventive cognitions amongst secondary school students in Uganda.: Health Educ Res. 1995 Jun;10(2):155-62. Unique Identifier : AIDSLINE HTA/96368393; Abraham SC; Rubaale TK; Kipp W; Department of Epidemiology and Public Health, Ninewells Hospital; and Medical School, Dundee, UK.; A self-completion questionnaire was used to survey HIV-preventive cognitions among secondary school students in Kabarole district, Uganda . An encouraging pattern of HIV-preventive beliefs was observed, suggesting that health education efforts have been effective in establishing bas
Staff stress in AIDS prevention and service organizations: implications for health education practice.: Health Educ Res. 1995 Jun;10(2):163-77. Unique Identifier : AIDSLINE HTA/96368394; Janz NK; Wren PA; Israel BA; Health Behavior and Health Education Department, School of Public; Health, University of Michigan, Ann Arbor 48109-2029, USA.; The purpose of this study was to identify the frequency of staff stressors and their association with programmatic factors in 51 AIDS prevention and service projects funded by the Robert Wood Johnson Foundation. The methodology included both quantitative (i.e. closed-ended survey questions) and qualitative (i.e. in-de
Criteria for the appropriate drug utilisation of immunoglobulin.: Pharmacoeconomics. 1996 May;9(5):417-29. Unique Identifier : AIDSLINE HTA/96358349; Thurmann P; Harder S; Department of Clinical Pharmacology, University Hospital; Frankfurt/Main, Germany.; Intravenous immunoglobulins (IVIGs) are prepared from human plasma pools and further modified enzymatically or chemically. Despite careful selection of donors and inclusion of effective virus elimination steps in the production process, contamination with hepatitis C virus can still occur. IVIGs possess most of the ch
Blood & politics.: CAP Today. 1996 Mar;10(3):20, 22-4. Unique Identifier : AIDSLINE HTA/96387407; Titus K
Knowing when and how to notify donors, recipients.: CAP Today. 1996 Apr;10(4):63-7, 70. Unique Identifier : AIDSLINE HTA/96387412; Chapman B
Current good manufacturing practices for blood and blood components: notification of consignees receiving blood and blood components at increased risk for transmitting HIV infection--FDA. Final rule.: Fed Regist. 1996 Sep 9;61(175):47413-23. Unique Identifier : AIDSLINE AHA/96406120; The Food and Drug Administration ( FDA ) is amending the biologics regulations to require that blood establishments (including plasma establishments) prepare and follow written procedures for appropriate action when it is determined that Whole Blood, blood components (including recovere
Medicare and Medicaid programs: hospital standard for potentially HIV infectious blood and blood products--HCFA. Final rule.: Fed Regist. 1996 Sep 9;61(175):47423-34. Unique Identifier : AIDSLINE AHA/96406121; This final rule requires hospitals participating in the Medicare and Medicaid programs to take appropriate action when the hospitals learn that they have received whole blood, blood components (including recovered plasma), source plasma, and source leukocytes (hereafter referred to as blood or blood products) that are
Innovative new equipment lowers risks of needlesticks.: Health Facil Manage. 1996 Oct;9(10):68, 70, 72 passim. Unique Identifier : AIDSLINE AHA/96406128; Garvin M; University of Iowa Hospitals and Clinics, Iowa City, USA.
AIDS and neuro-ophthalmology.: Curr Opin Ophthalmol. 1995 Dec;6(6):34-40. Unique Identifier : AIDSLINE HTA/96358753; Currie J; Drug and Alcohol Services, Westmead Hospital, Australia.
Ocular manifestations of AIDS.: Curr Opin Ophthalmol. 1995 Dec;6(6):82-7. Unique Identifier : AIDSLINE HTA/96358760; Park KL; Smith RE; Rao NA; Doheny Eye Institute, Los Angeles, California, USA.; AIDS causes severe depression of the immune system through selective infection of CD4+ T lymphocytes. As such, certain infections and neoplasms occur in these patients often with ocular involvement. Among these, cytomegalovirus retinitis is by far the most common and remains a lead
The consequence of land mines on public health.: Prehospital Disaster Med. 1996 Jan-Mar;11(1):2-10. Unique Identifier : AIDSLINE HTA/96342631; Kakar F; Bassani F; Romer CJ; Gunn SW; Division of Emergency and Humanitarian Action, World Health; Organization (WHO), Geneva, Switzerland.; An estimated 110 million land mines scattered in 64 countries continue to terrorize people and destroy human lives long after wars and fighting have ceased. Despite efforts to clear these devices, their numbers continue to increase and their presence constitutes a substantial threat to public health in affected countr
Pharmacoeconomics of Pneumocystis carinii pneumonia in HIV-infected and HIV-noninfected patients.: Pharmacoeconomics. 1996 Jul;10(1):72-8. Unique Identifier : AIDSLINE HTA/96368413; Nicolau DP; Ross JW; Quintiliani R; Nightingale CH; Department of Pharmacy, Hartford Hospital, Connecticut, USA.; Despite the proven effectiveness of Pneumocystis carinii pneumonia (PCP) prophylaxis in both HIV-infected and HIV-noninfected patients, PCP remains an important cause of serious pulmonary infection. Because PCP is a frequent event requiring inpatient admission at our institution, we conducted a study to define the pha
Estimating the cost effectiveness of atovaquone versus intravenous pentamidine in the treatment of mild-to-moderate Pneumocystis carinii pneumonia.: Pharmacoeconomics. 1996 Jun;9(6):525-34. Unique Identifier : AIDSLINE HTA/96339251; Zarkin GA; Bala MV; Wood LL; Bennett CL; Simpson K; Dohn MN; Center for Economics Research, Research Triangle Institute,; Research Triangle Park, North Carolina, USA.; Pneumocystis carinii pneumonia (PCP) is the most common severe opportunistic infection, and one of the most costly, among people with AIDS. Over 50% of patients experience toxic effects of the major anti-PCP medications- cotrimoxazole (trimethoprim-sulfamethoxazole) and pentamidine. Recently, the US Food and Drug Admi
AIDS policies and procedures. Pike, Plymouth Meeting, PA 19462, USA.: In: Healthcare Risk Control. Volume 1. Plymouth Meeting, PA : ECRI, 1996. 20 p. (SAQ; no. 8) Unique Identifier : AIDSLINE HTX/96924101; A hospital s legal responsibilities with regard to human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) are constantly being redefined. A crucial risk management strategy is the careful crafting and updating of policies that comply with relevant laws, guidelines, and regulations and that t
Preventing accidental needlesticks and sharps injuries. Pike, Plymouth Meeting, PA 19462, USA.: In: Healthcare Risk Control. Volume 1. Plymouth Meeting, PA : ECRI, 1996. 10 p. (SAQ; no. 9) Unique Identifier : AIDSLINE HTX/96924102; Accidental needlesticks and other sharp-object injuries occur frequently in healthcare facilities, placing at risk those providers who use the sharps (e.g., physicians, nurses) and those who may come in contact with the sharps after use (e.g., housekeeping personnel). A number of clinical procedures and housekeeping
Issues and implications in the counseling of survivors of multiple AIDS-related loss.: Death Stud. 1996 Jul-Aug;20(4):389-413. Unique Identifier : AIDSLINE HTA/96926373; Nord D; Maple Valley, Washington, USA.; Survivors of multiple AIDS-related loss face a unique phenomenon for which existing theories and diagnostic criteria regarding grief and trauma are inadequate. Unresolved grief and complicated bereavement are normal responses to multiple loss. This distinctive experience and the resulting symptoms have implications f
Breaking barriers, building bridges. [videorecording]: Communities Washington, D.C. : Dept. of Health and Human Services, [1994] 16 videocassettes (20 hr., 20 min., 51 sec) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9611093
The:second decade of AIDS : [a mental health practice training video]. [videorecording]: [Williston, VT] : Hatherleigh Co., c1996 2 videocassettes (4 hr.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9612472; Shernoff M
Age of AIDS. [videorecording]: [Washington, D.C. : Gallaudet University], c1991 1 videocassette (28 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9610173; (Producer) Experts on deaf health issues and deaf people with AIDS discuss community services and prevention for the deaf community.
Living with HIV : an overview. [videorecording]: Princeton, NJ : Films for the Humanities & Sciences, c1996 1 videocassette (21 min.) : sd., col. ; 1/2 in (Cutting edge medical report) Unique Identifier : AIDSLINE AV/9615199; (Producer) The most recent advancements in the research and treatment of AIDS/HIV and opportunistic infections are the subject of this program. Featuring four respected medical professionals in AIDS research, the program clarifies the common misconceptions about HIV/AIDS of the general public as well as the medical
HIV/AIDS surveillance data base. Windows version, version 1.0. [computer file]: [Washington, D.C.] : U.S. Bureau of the Census, 1996 7 computer disks ; 3 1/2 in. + 1 guide (36 p.) Unique Identifier : AIDSLINE AV/9612084; (Producer) Represents the latest major update to the HIV/AIDS surveillance data base. It incorporates all available epidemiological information for developing countries presented at the Third International Conference on AIDS in Asia and the Pacific, Chiang Mai, Thailand , Septem
Indinavir: lightening the load. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):6-11. Unique Identifier : AIDSLINE AIDS/96701849; MacDougall DS; Some of the most dramatic reductions in HIV viremia have been observed among patients treated with indinavir sulfate ( Crixivan ). How the hypothesis that HIV protease maintains the inf
1996 National Farmworker Health Conference. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):12-4, 16, 19. Unique Identifier : AIDSLINE AIDS/96701850; Dougherty S; Health care providers who serve farmworkers are challenged by the geographical distribution of their clients, language differences, and opposition from Congress. At the 1996 National Farmworker Health Conference, clinicians and researchers considered how to deal with these challenges. The number of U.S. migrant and se
Tuberculosis in farmworkers. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):15. Unique Identifier : AIDSLINE AIDS/96701851; Nist A; Collier County Public Health Unit, Naples, FL.; It is believed that the HIV epidemic will increasingly fuel the TB epidemic in farmworkers in the years to come as it increases the likelihood that dormant TB infection will progress to active TB disease. Several case studies of TB in HIV-positive farmworkers show the problems inherent in maintaining treatment, reveal
The ascendancy--and the future--of combination antiretroviral and immunomodulatory therapies. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):20-5. Unique Identifier : AIDSLINE AIDS/96701852; Cooper DA; University of New South Wales, Sydney, Australia.; There has been a recent demise in antiretroviral monotherapy and the ascendancy of combination therapy for HIV-infected patients. A few of the trials that established the change and a few that may contribute to the continuing evolution of antiretroviral therapy are bri
FDA approves cidofovir for treatment of CMV retinitis. Food and Drug Administration. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: J Int Assoc Physicians AIDS Care. 1996 Aug;2(8):30. Unique Identifier : AIDSLINE AIDS/96701853; In June 1996 the Food and Drug Administration ( FDA ) granted marketing clearance of cidofovir injection (Vistide) for the treatment of CMV retinitis in patients with AIDS. Two studies demonstrated cidofovir s ability to slow prog
Two worlds, two hopes. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Clin Care. 1996 Sep;8(9):71-2. Unique Identifier : AIDSLINE AIDS/96701854; Zuger A; The International Conference on AIDS, held in Vancouver in July 1996, showed two distinct themes. One was optimism, and researchers were cheered by the advent of viral load testing, the development of other antiretroviral drugs, and new schemes to slow the progression of the disease. However, at the same time that the
A new focus on primary HIV infection. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Clin Care. 1996 Sep;8(9):72, 75. Unique Identifier : AIDSLINE AIDS/96701855; Hecht F; There are two potential goals of very early treatment of HIV infection. One is to see whether aggressive treatment during the primary phases of infection can improve the long-term course. The other is to test the feasibility of eradicating HIV infection. Eradication may be simpler in newly-infected patients who are li
A virologist's view from Vancouver. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Clin Care. 1996 Sep;8(9):73, 75. Unique Identifier : AIDSLINE AIDS/96701856; Japour A; Researchers and clinicians at the Vancouver International Conference on AIDS noted that remarkable advances have been made in antiretroviral therapy, and all classes of drugs show viral load reductions. Patients need to be increasingly aware of the need for complete compliance with their drug regimens, as resistance i
Continued therapeutic improvements for OIs. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Clin Care. 1996 Sep;8(9):74. Unique Identifier : AIDSLINE AIDS/96701857; Currier J; Several presentations at the Vancouver International Conference on AIDS reported continued improvements in the treatment of opportunistic infections. New and ongoing studies for MAC were reported, including one that alerted clinicians to the dangers of using high-dose clarithromycin for therapy. PCP, for which there a
Nelfinavir protease inhibitor study recruiting. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Aug 23;(No 253):1. Unique Identifier : AIDSLINE AIDS/96701858; Agouron Pharmaceuticals, Inc. is recruiting 200 participants in 8 U.S. cities for its clinical trial for nelfinavir (VIRACEPT), an experimental protease inhibitor. Volunteers must already be taking a nucleoside analog drug such as
Five-drug or six-drug antiretroviral therapy--conversation with Steven Scheibel, M.D. [interview by John S. James] Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Aug 23;(No 253):1-2. Unique Identifier : AIDSLINE AIDS/96701859; Scheibel S; In an interview with AIDS Treatment News, Steven F. Scheibel, M.D. discusses the results of two small studies in San Francisco that reported good HIV suppression with regimens of five-drug and six-drug antiretroviral therapy. The studies included a clinical trial of 6 patients infected with HIV-1 within the past 6 mon
1592 -- new experimental antiretroviral. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Aug 23;(No 253):2-3. Unique Identifier : AIDSLINE AIDS/96701860; James JS; Glaxo Wellcome is developing a nucleoside analog which may have a stronger anti-HIV effect than other approved nucleoside analogs. In phase I/II human trials, 1592U89 (also called 1592) has already been administered to 80 volunteers with CD4 counts of 200-500 who had less
Medical marijuana: California update. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Aug 23;(No 253):3-5. Unique Identifier : AIDSLINE AIDS/96701861; James JS; The Cannabis Buyers Club in San Francisco remains closed after it was raided by the office of California Attorney General Dan Lungren. Many individuals with serious illnesses such as AIDS and cancer are without safe access to medical marijuana to relieve the symptoms of their diseases. The need for access to medicina
Arizona court upholds HIV testing of juvenile convicted of sex offense. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):1, 10. Unique Identifier : AIDSLINE AIDS/96701862; An Arizona State Appeals Court ruled that a State law forcing juvenile sex offenders to submit to HIV-antibody testing does not violate Fourth Amendment protection. The State s interest in helping victims to learn the HIV status of their attacker outweighs the attacker s privacy interests. However, only the victim or
Union seniority supersedes ADA on issue of job accommodation. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):1, 11. Unique Identifier : AIDSLINE AIDS/96701863; The 7th U.S. Circuit Court of Appeals ruled that the Americans with Disabilities Act (ADA) does not require an employer to violate a union s seniority system in an attempt to provide a reasonable accommodation to a worker with a disability. Terry Eckles, diagnosed with epilepsy, could only return to work based on cert
Lawyer fined for not disclosing client's HIV infection. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):2. Unique Identifier : AIDSLINE AIDS/96701864; Robert Griffith, handling the wrongful death lawsuit of a Massachusetts inmate, has been fined $15,000 because he did not disclose to the defense that the inmate was HIV-positive. Inmate Morris Pina, Jr. died after being beaten by police officers; he was refused medical care for the injuries. U.S. District Judge Mark
HIV not communicable in restaurant setting, court rules. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):3. Unique Identifier : AIDSLINE AIDS/96701865; The case of Sanchez v. Lagoudakis may be brought before the Michigan Supreme Court for the third time. In 1988, restaurateur Kostas Lagoudakis ordered then waitress Dorene Sanchez to undergo an HIV-antibody test at her own expense because several customers suspected that she might be HIV-positive. Sanchez tested negat
Fear of AIDS is actionable if reckless conduct is alleged. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):4-5. Unique Identifier : AIDSLINE AIDS/96701866; A New Jersey appeals court allowed a plaintiff to seek damages for fear of contracting HIV even though there was no evidence of actual exposure to the virus. Office cleaner Karen Williamson sued the medical offices of Drs. Waldman, Feldman, and Losman after puncturing her hand on a lancet that had been improperly disp
Statement in open court forecloses couple's privacy claim. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):6-7. Unique Identifier : AIDSLINE AIDS/96701867; A three-judge panel of the 6th U.S. Circuit Court of Appeals ruled that once a person discloses his or her HIV status in the public domain, the information is no longer private. This ruling settles a lawsuit filed by John and Jane Doe. Mr. Doe, sentenced to 6 months in jail, persuaded the sentencing judge to grant him
Court poses question: is policy void if obtained by fraud? Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):7. Unique Identifier : AIDSLINE AIDS/96701868; The 1st U.S. Circuit Court of Appeals asked Massachusetts highest court to determine whether an insurance company can void an incontestable life insurance policy if it was obtained by fraud. No case law exists to cover the issues in this dispute. The option by the State s Supreme Judicial Court could impact Massachus
Court says HIV is an illness, not a pre-existing condition. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):8. Unique Identifier : AIDSLINE AIDS/96701869; A three-judge panel of the Tennessee Court of Appeals upheld a lower court s dismissal of a lawsuit filed by Krzystof Krakowiak. Krakowiak s insurer, Paul Revere Life Insurance Company, refused to pay disability benefits after learning that he had failed to state in his application that he was HIV-positive. The policy
Evidence of a disability renders policy contestable, judge says. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):8. Unique Identifier : AIDSLINE AIDS/96701870; U.S. District Judge Justin Quackenbush of California upheld the validity and incontestability clause of an insurance policy that allowed an insurer to back out if the policy holder developed any disability that prevented him from working during the first two years of coverage. Mutual Life Insurance Company of New York
Rhode Island kills bill forcing inmates to reveal HIV status. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):9. Unique Identifier : AIDSLINE AIDS/96701871; Rhode Island Governor Lincoln Almond vetoed legislation allowing State prison guards to learn the names of adult inmates infected with HIV. The bill was brought before the governor for two consecutive years. Almond stated that the disclosure requirement, supported by the Brotherhood of Correctional Officers, is not me
Court overturns ruling on housing of homeless with HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):9. Unique Identifier : AIDSLINE AIDS/96701872; The New York Court of Appeals struck down a lower court finding that New York City s shelter program for the homeless with HIV failed to promise minimum protection against tuberculosis (TB). A class action led by Kenneth Mixon claimed that people who do not fit the Federal definition of AIDS are placed in a segregated
Bus driver sues. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Policy Law. 1996 Sep 6;11(16):12. Unique Identifier : AIDSLINE AIDS/96701873; A bus driver, known as John Doe, sued his employer, alleging that he was fired when he voluntarily disclosed that he was HIV-positive and needed a rest from the long hours of driving. The driver sued for back wages, benefits, and compensatory and punitive damages under the New Jersey Law Against Discrimination. Academ
KS treatment inches forward. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):9. Unique Identifier : AIDSLINE AIDS/96701874; Vazquez E; A study of doxorubicin hydrochloride (Doxil) showed effectiveness in treating Kaposi s sarcoma (KS) with less toxicity than seen in patients using the combination bleomycin and vincristine (BV). The manufacturer, Sequus Pharmaceuticals, plans to file for Food and Drug Administratio
Nevirapine approval expands combo possibilities--and HIV suppression. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):9. Unique Identifier : AIDSLINE AIDS/96701875; Vazquez E; The Food and Drug Administration ( FDA ) granted accelerated approval to nevirapine ( Viramune ) on June 24, 1996. Nevirapine is the first of another new
Take a load off. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):10-1. Unique Identifier : AIDSLINE AIDS/96701876; McGuire S; Viral load testing is a valuable tool for clinicians and physicians to use to determine how well a treatment regimen is working. A large body of evidence now shows that doctors can use viral load to make decisions about HIV treatments. Approved tests are described, and recommended guidelines for the use of the data ar
Another protease inhibitor proves highly effective. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):11. Unique Identifier : AIDSLINE AIDS/96701877; Prescott LM; Nelfinavir ( Viracept ) is a well-tolerated and effective protease inhibitor, especially when used in combination with nucleoside analogues. When used in triple combination, it is even more effective. An ongoing trial showed that 11 patients showed no d
Opportunistic infections. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):12-3. Unique Identifier : AIDSLINE AIDS/96701878; Vazquez E; Opportunistic infections (OIs) remain a serious problem for HIV-positive patients who remain vulnerable to fungal, parasitic, and bacterial infections. OIs continue to cause severe illness and death in many HIV-positive patients. Researchers are looking at ways to diagnose and prevent PCP, HIV-related cancers,
Women and HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):14-5, 37. Unique Identifier : AIDSLINE AIDS/96701879; Vazquez E; HIV infection rates in women continue to climb and have increased threefold since 1985. HIV infection is now the third leading cause of death in U.S. women aged 25 to 40. Women frequently do not take precautions to protect themselves from sexually transmitted diseases, and are prone to candidiasis. Pregnancy in HIV-po
Treating HIV in 1996. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):17-22. Unique Identifier : AIDSLINE AIDS/96701880; McGuire S; Panel members from the International AIDS Society (IAS) presented the latest trends in AIDS treatment at the Vancouver conference. Guidelines on when to start initial therapy were laid out, and the progression of the primary infection was described. The guidelines recommend treatment with the most potent therapy avail
How low can you go. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):23. Unique Identifier : AIDSLINE AIDS/96701881; Vazquez E; With some treatments reducing viral loads to undetectable levels, there is hope that AIDS may be totally suppressed or eradicated. However, keeping viral loads low requires powerful drug combinations and continuous monitoring. Experts agree that patients must continue drug therapy as a prophylaxis, and that drug-resis
On the other hand...researchers look at who's using which alternative treatments. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):28-9. Unique Identifier : AIDSLINE AIDS/96701882; McGuire S; There is no consensus on the use of alternative therapies in AIDS treatment. However, studies show that anywhere between one-third and all patients use alternative treatments, often in concert with their medically-prescribed regimen. Alternative therapies used include herbal preparations, vitamins and minerals, massag
How much protection is enough? Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):31-2. Unique Identifier : AIDSLINE AIDS/96701883; Wakefield SF; Night Ministry, Chicago, IL.; The debate on preventive HIV vaccines at the International AIDS Conference made global economic differences visible. The typical cost of $15,000 per year to treat AIDS patients is beyond the reach of 90 percent of the world s HIV population, most of whom live in Africa and Asia. However, no vaccine developed to date h
Children of the epidemic. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):35-6. Unique Identifier : AIDSLINE AIDS/96701884; Vazquez E; The World Health Organization (WHO) and the United Nations estimate that between 1.3 million and 3 million children worldwide have died of AIDS. Drug therapy may not extend children s lives, but it does provide some benefit in delaying the progression to AIDS. Fewer drugs are approved
Optimism in the North, growing numbers in the South. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Posit Aware. 1996 Sep/Oct;7(5):38. Unique Identifier : AIDSLINE AIDS/96701885; McGuire S; People living with HIV in the developed countries of North America, Europe, and Australia have more reason than at any other time in the epidemic s history to be optimistic about being able to live longer and more productively. In those countries, most people either enjoy health
Fauci presents NIAID strategy for HIV vaccine development. National Institute of Allergy and Infectious Diseases. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:1, 19. Unique Identifier : AIDSLINE AIDS/96701886; Folkers G; Anthony S. Fauci, M.D., National Institute of Allergy and Infectious Diseases (NIAID) director, presented the strategies for HIV vaccine research and development for the Institute at the Conference on Advances in AIDS Vaccine Development: 1996. The plan, calling for both fundamental and empiric research, seeks also to
CPCRA 007: preliminary results of combination antiretroviral study. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:2. Unique Identifier : AIDSLINE AIDS/96701887; Randall P; Preliminary data from the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) showed that in patients with no prior use of zidovudine ( AZT ), combination therapy was more effective than
ACTG 152: new insights into pediatric antiretroviral therapy. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:3. Unique Identifier : AIDSLINE AIDS/96701888; Bowersox J; Final results of the pediatric clinical trial, AIDS Clinical Trials Group (ACTG) 152, show that initial antiretroviral therapy with didanosine (ddI) alone slows disease progression in HIV-infected children as effectively as combination therapy with ddI and
Two new protease inhibitors approved by FDA. Food and Drug Administration. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:4-5. Unique Identifier : AIDSLINE AIDS/96701889; Folkers G; The Food and Drug Administration ( FDA ) approved two new protease inhibitors--ritonavir and indinavir--for the treatment of HIV infection in adults. Ritonavir (
Studies examine relationship of viral load to maternal HIV transmission. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:6-7. Unique Identifier : AIDSLINE AIDS/96701890; Doepel LK; The results of several recent studies have shown that HIV transmission from mother to infant is more likely to occur in situations where women have a higher level of HIV RNA in their bloodstream than in women with a smaller viral load. Four separate presentations at the 3rd Conference on Retroviruses and Opportunistic
MACS: maintaining weight decreases risk of death. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:8. Unique Identifier : AIDSLINE AIDS/96701891; A recent report from the NIAID-supported Multicenter AIDS Cohort Study (MACS) found that prior to an AIDS diagnosis, men who maintain their weight are more likely to live longer than men who lose too much weight. Previous data predicted early death for persons with AIDS who had severe weight loss. The new findings sug
Two-drug treatment effective against recurrent CMV retinitis. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:8. Unique Identifier : AIDSLINE AIDS/96701892; In a study of 279 patients, sponsored by the National Eye Institute, the National Institutes of Allergy and Infectious Diseases (NIAID), and the National Center for Research Resources, investigators found that daily intravenous administration of both foscarnet and ganciclovir is more effective than either drug alone f
3TC treatment may slow HIV mutations, development of drug resistance. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:8-9. Unique Identifier : AIDSLINE AIDS/96701893; According to a recent study conducted by the Albert Einstein College of Medicine, HIV develops a mutation (M184V) in patients treated with 3TC (lamivudine). The mutation appears to be resistant to 3TC but decreases the rate at which other mutations de
Miscarriage more likely in HIV-infected women. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:9. Unique Identifier : AIDSLINE AIDS/96701894; NIAID-supported researchers at the Baylor College of Medicine found that miscarriage is three times more likely to occur in HIV-infected women than healthy women. More than 11 percent of the 124 HIV-infected women followed had miscarriages. The typical rate is less than 3 percent for non-HIV-infected pregnant women. C
Blacks, Hispanics not at increased risk for AZT side effects. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:9, 20. Unique Identifier : AIDSLINE AIDS/96701895; Researchers at the University of California, San Francisco/San Francisco General Hospital analyzed data from two large NIAID-supported studies of AZT monotherapy (ACTG 016 and ACTG 019) and found that black and Hispanic patients with HIV are not at a
Fauci presents new findings on HIV escape mechanisms and HIV suppressor molecules. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:10-1. Unique Identifier : AIDSLINE AIDS/96701896; Folkers G; The National Institute of Allergy and Infectious Diseases (NIAID) director, Anthony S. Fauci, M.D., presented findings at the 3rd Conference on Retroviruses and Opportunistic Infections that may help shed light on how HIV escapes the body s immune response following initial infection. NIAID researchers have found that
NIAID international AIDS research. National Institute of Allergy and Infectious Diseases. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:12-5. Unique Identifier : AIDSLINE AIDS/96701897; Bowersox J; With the hope of developing a greater understanding of HIV transmission in the developing world, the National Institute of Allergy and Infectious Diseases (NIAID) is supporting its first program of international HIV prevention trials. Investigators will test HIV prevention strategies in Southeast Asia, sub-Saharan Afr
Highlights of AIDS vaccine meeting. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:16-9. Unique Identifier : AIDSLINE AIDS/96701898; Doepel LK; Highlights from the Conference on Advances in AIDS Vaccine Development: 1996 at the National Institutes of Health (NIH) on February 11-15, 1996, are described. The need for cooperation from both government and industry in the search for new treatments and a vaccine for HIV was emphasized. Scientists discussed the deve
Putative KS virus grown in laboratory. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Mar;:20. Unique Identifier : AIDSLINE AIDS/96701899; Folkers G; For the first time in a laboratory, researchers at the University of California, San Francisco, have grown the herpesvirus, thought to cause Kaposi s sarcoma (KS). The virus, known as Kaposi s sarcoma-associated herpes virus (KSHV), was grown in a cell line derived from a lymph system cancer. This advancement may have
NIAID researchers identify cofactors for entry of HIV into cells. National Institute of Allergy and Infectious Diseases. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Jun;:1, 10-1. Unique Identifier : AIDSLINE AIDS/96701901; Folkers G; Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) report that they have identified fusion cofactors that, for certain strains of HIV-1, make both human and nonhuman CD4+ cells susceptible to HIV fusion and infection. Researchers demonstrated that these HIV-1 strains require, in addition t
Immune system activation boosts HIV replication in HIV-infected people. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Jun;:3. Unique Identifier : AIDSLINE AIDS/96701902; Folkers G; Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) report that the activation of the immune system by other stimuli results in an increase in HIV replication. Sharilyn Stanley, M.D., NIAID Director Anthony S. Fauci, M.D., and colleagues inoculated 13 asymptomatic HIV-infected people and 1
Low-dose oral alpha interferon study opens. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Jun;:4-5. Unique Identifier : AIDSLINE AIDS/96701903; Randall P; The National Institute of Allergy and Infectious Diseases (NIAID) is sponsoring a multicenter study to examine the effects of low-dose oral alpha interferon (LDOAI) on the symptoms caused by HIV disease. The four-arm study, to be conducted at 14 sites in the United States , will compare
Gene therapy prolongs CD4+ T cell survival in HIV-infected individuals. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Jun;:7. Unique Identifier : AIDSLINE AIDS/96701904; Folkers G; Gary Nabel, M.D., Ph.D., of the University of Michigan, and his colleagues report that they can lengthen the survival of important immune system cells, usually depleted during the course of HIV disease, by genetically modifying cells. In the study, supported in part by the National Institute of Allergy and Infectious
Increased risk of cervical abnormalities among HIV-infected African women. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: NIAID AIDS Agenda. 1996 Jun;:9, 11. Unique Identifier : AIDSLINE AIDS/96701905; Folkers G; A study of 268 women in Malawi (116 HIV-positive women, 152 HIV-negative women) found that the HIV-infected women were 3 times more likely to have persistent human papillomavirus infections (HPV), and twice as likely to have cervical abnormalities. Also, the most immunosuppressed w
Protease inhibitors. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Treat Rev. 1996 Aug;(No 22):2-7. Unique Identifier : AIDSLINE AIDS/96701906; There are now nine approved anti-HIV drugs, all of which are meant to keep the level of HIV as low as possible, prevent further damage to the immune system, and stop the progression of the disease. The combination of drugs prescribed depends on which the doctor feels will best stop disease progression based on the sid
A new class of anti-HIV drugs. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Treat Rev. 1996 Aug;(No 22):8-9. Unique Identifier : AIDSLINE AIDS/96701907; A new class of anti-HIV drugs has entered the treatment arena. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) interfere with infected cells and suppress their ability to replicate. Delaviradine ( Rescriptor ) and
F-ddA for HIV. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Treat Rev. 1996 Aug;(No 22):10. Unique Identifier : AIDSLINE AIDS/96701908; The National Cancer Institute (NCI) is currently testing F-ddA, related to ddI but easier to absorb. To qualify for the trial, patients must have 100-400 T4 counts and have been off all anti-HIV drugs for 3 weeks. Interested patients are directed to call the AIDS Treatment Data Network for a referral.
Garlic for cryptosporidiosis? Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Treat Rev. 1996 Aug;(No 22):11. Unique Identifier : AIDSLINE AIDS/96701909; The AIDS Research Alliance in California has been testing the effectiveness of garlic in combating cryptosporidiosis, a parasitic infection of the intestinal tract. The test involved patients taking liquid Allicin mixed with distilled water twice daily. Side effects included the expected garlic taste and smell, but pa
Treatments and trials for Kaposi's sarcoma. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: Treat Rev. 1996 Aug;(No 22):11. Unique Identifier : AIDSLINE AIDS/96701910; A trial at the National Cancer Institute (NCI) is testing the effectiveness of thalidomide in treating Kaposi s sarcoma (KS), a type of cancer that affects many AIDS patients. Thalidomide is thought to inhibit angiogenesis, the development of new blood vessels that contribute to KS progression. Other trials are being
Human growth hormone approved for wasting. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Sep 6;(No 254):1-4. Unique Identifier : AIDSLINE AIDS/96701911; James JS; Serono Laboratories, Inc. has recently been given accelerated Food and Drug Administration ( FDA ) approval for Serostim, a recombinant human growth hormone genetically engineered from mammalian cells, for treatment of AIDS-related wasting. While the price has not been established, Sero
ddI plus d4T. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Sep 6;(No 254):4. Unique Identifier : AIDSLINE AIDS/96701912; James JS; A study of 85 volunteers divided into 5 separate dosage groups found fairly good viral suppression from a combination of didanosine plus stavudine . A 1.3 log viral load reduction was sustained for at least 52 weeks when the 5 dose groups were pooled t
Ritonavir plus saquinavir: two trials with different results. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Sep 6;(No 254):5-6. Unique Identifier : AIDSLINE AIDS/96701913; Mascolini M; Two trials testing the combination of the protease inhibitors , ritonavir and saquinavir, recently came to different conclusions, possibly explained by differences in trial size, drug dosage, and dis
CKR-5--understanding the news. Clearinghouse, AIDS Newsletter Database, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5714.: AIDS Treat News. 1996 Sep 6;(No 254):6-7. Unique Identifier : AIDSLINE AIDS/96701914; James JS; A recent discovery about how HIV infects cells and causes disease has revealed that some racial or ethnic groups, but not others, may be very resistant or even immune to HIV infection through sexual transmission. This discovery opens new doors for scientific progress in understanding HIV pathogenesis that may lead to
Power imbalances and therapy.: Focus. 1996 Aug;11(9):1-4. Unique Identifier : AIDSLINE AIDS/96701915; Boyd KK; The therapeutic relationship between a therapist and a client is inherently unbalanced in terms of power. The client invests the therapist with power, which the therapist then uses to help the client empower him/herself. This power imbalance can impede therapy when societal power dynamics, such as race, socioeconomic
Clearinghouse: power and privilege.: Focus. 1996 Aug;11(9):4-5. Unique Identifier : AIDSLINE AIDS/96701916; A bibliography of papers, journal articles, and books related to the power imbalances in the patient-professional relationship is provided. The referenced material considers cultural and ethnic differences, counselor development, empowerment techniques, and countertransference issues in therapy with HIV-positive and A
White privilege and the "silenced dialogue".: Focus. 1996 Aug;11(9):5-6. Unique Identifier : AIDSLINE AIDS/96701917; Kendall FE; The impact of White privilege in the HIV-related counseling and educational environment is explored. The most negative consequence of this phenomenon may be silencing people of other cultures for whom the White frame of reference is not the norm. White counselors often silence others without awareness or intention. Wh
Drug interactions: trials and tribulations.: Crit Path AIDS Proj. 1996 Fall;(No 31):4-6. Unique Identifier : AIDSLINE AIDS/96701918; With the increased availability and use of combination and complementary drug therapies for people living with HIV/AIDS, patients and their physicians now must consider how these new regimens interact. Fifteen drugs are listed with a description of the toxicities or known side effects the drug may cause. Other substan
HIV adult standard of care. ACT UP.: Crit Path AIDS Proj. 1996 Fall;(No 31):10-6. Unique Identifier : AIDSLINE AIDS/96701919; AIDS Coalition To Unleash Power Philadelphia, Philadelphia, PA.; The revised HIV Adult Standard of Care guidelines, produced by ACT UP/Philadelphia, are printed. The extensive table summarizes the minimum standard of care needed for individuals with HIV infection to maximize their quality and length of life. Divided into sections by T4 cell count, the table includes diagnostic test
Eradication of HIV: the cutting edge of clinical trial design.: Crit Path AIDS Proj. 1996 Fall;(No 31):16-7. Unique Identifier : AIDSLINE AIDS/96701920; The AIDS Clinical Trials Group (ACTG) will begin in October 1996, a new clinical trial that will compare three long-term maintenance regimens. Recruits in the randomized double-blind study, ACTG 343, will receive induction therapy with AZT ,
Lethal new worm discovered in PWA.: Crit Path AIDS Proj. 1996 Fall;(No 31):17-8. Unique Identifier : AIDSLINE AIDS/96701921; Doctors recently identified a new form of parasitic worm that was associated with the death of a person with AIDS from the San Francisco Bay area about 1 year ago. The man acquired HIV 5 years ago, but was hospitalized in 1994 with stomach and back pain, weight loss, night sweats and fever. After the worm destroyed pa
Nevirapine, the first of a new class of NNRTI drugs arrives in pharmacies.: Crit Path AIDS Proj. 1996 Fall;(No 31):18-9. Unique Identifier : AIDSLINE AIDS/96701922; Now available in pharmacies, the first of a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been licensed. Nevirapine (marketed as Viramune ) is different from nucleoside reverse transcriptase inhibitors because it binds at a
Finally--international endorsement of a non-condom HIV prevention alternative.: Crit Path AIDS Proj. 1996 Fall;(No 31):19-20. Unique Identifier : AIDSLINE AIDS/96701923; Forbes A; The Joint United National Programme on HIV/AIDS announced last year that Advantage 24, a Nonoxynol-9 (N-9) product, had been shown to prevent transmission of sexually transmitted diseases, including HIV, during heterosexual vaginal intercourse. Advantage 24 uses a low dose of N-9 with a bio-adhesive gel that forms a t
Medical marijuana--once again--blocked. Marijuana Policy Project.: Crit Path AIDS Proj. 1996 Fall;(No 31):21. Unique Identifier : AIDSLINE AIDS/96701924; Marijuana Policy Project, Washington, DC.; The Clinton Administration is continuing to block the research efforts of Dr. Donald Abrams, University of California, San Francisco, to study the safety and effectiveness of marijuana in stimulating the appetites and reducing nausea of people with AIDS wasting syndrome. Dr. Abrams does not require money for the study
AIDS information on the Internet (Part 2): Critical Path Internet services.: Crit Path AIDS Proj. 1996 Fall;(No 31):27-30. Unique Identifier : AIDSLINE AIDS/96701925; Bauer R; World Wide Web technology on the Internet provides a cost-effective means for reaching AIDS service providers and researchers across the world. It provides a means for obtaining and disseminating information worldwide in a time-sensitive environment. However, because of cost restrictions, many underserved communities
Incoming NTZ blocked by US customs. People With AIDS Health Group.: Crit Path AIDS Proj. 1996 Fall;(No 31):33-4. Unique Identifier : AIDSLINE AIDS/96701926; People With AIDS Health Group, New York, NY.; U.S. Customs in Chula Vista, California, seized an incoming shipment of nitrazoxanide (NTZ), the first drug that shows promise against Cryptosporidium parvum infection in people living with HIV/AIDS. Cryptosporidiosis is a source of diarrhea that has resulted in the death of thousands of people with AIDS. NTZ, approve
AIDS activists secure approval for human growth hormone (Serostim).: Crit Path AIDS Proj. 1996 Fall;(No 31):34. Unique Identifier : AIDSLINE AIDS/96701927; The Food and Drug Administration ( FDA ) has given a verbal commitment to accelerated approval for recombinant human growth hormone (Serostim) for AIDS-associated wasting syndrome. The drug, manufactured by Serono Laboratories, is the first of its kind that directly affects the metaboli
Philadelphia area AIDS/HIV clinical trials.: Crit Path AIDS Proj. 1996 Fall;(No 31):35-9. Unique Identifier : AIDSLINE AIDS/96701928; A listing of currently active clinical trials in the Philadelphia, PA, area is provided. Trials are listed that examine anti-HIV therapies, immune-based therapies, therapies for the prevention of opportunistic infections, and treatments for opportunistic infection and AIDS-related conditions. One study is actively rec
Compassionate use and treatment IND programs.: Crit Path AIDS Proj. 1996 Fall;(No 31):40-67. Unique Identifier : AIDSLINE AIDS/96701929; For individuals with HIV/AIDS who are unable to participate in ongoing clinical trials or who have no other treatment options, compassionate use and treatment IND (Investigational New Drug) programs are available. A fairly inclusive list of drugs for the treatment of HIV disease that are available through compassionat
Benefits planning--what you must know: interview with Daniel Fortuno, AIDS Benefits Counselors. [interview by John S. James]: AIDS Treat News. 1996 Sep 20;(No 255):1, 4-8 cont. Unique Identifier : AIDSLINE AIDS/96701930; Fortuno D; Daniel Fortuno, a counselor with AIDS Benefits Counselors (ABC), summarizes key insurance and benefits information for persons living with AIDS (PWAs), particularly those who reside in California. Fortuno explains the managed care concept and basic health insurance terms, such as pre-existing conditions, health mainte
Nelfinavir (Viracept) expanded access announced.: AIDS Treat News. 1996 Sep 20;(No 255):4. Unique Identifier : AIDSLINE AIDS/96701931; Agouron Pharmaceuticals, Inc. began an expanded-access program for nelfinavir, an experimental protease inhibitor. Qualified patients must be HIV-positive, at least 13 years of age, and have a CD4 count less than or equal to 50. Applicants may not have used nelfinavir previously an
New wave antiretrovirals.: GMHC Treat Issues. 1996 Sep;10(9):1-3. Unique Identifier : AIDSLINE AIDS/96701932; Smart T; Researchers are investigating aspects of the life cycle of HIV that can be exploited by new drugs. Promising compounds include those that block the fusion of HIV to cells; dextran sulfate is an example of such a drug. Reverse transcriptase inhibitors continue to receive attention, with the focus placed on dealing with
Opportunistic infections in Vancouver.: GMHC Treat Issues. 1996 Sep;10(9):4-6. Unique Identifier : AIDSLINE AIDS/96701933; Marco M; Participants at the XI International Conference on AIDS in Vancouver appeared impressed by the improvements being made in the diagnosis, treatment, and prophylaxis of AIDS-related opportunistic infections. Improvements in the following areas are discussed: cytomegalovirus infection
Outdated yet out-of-reach: AIDS society treatment guidelines at the International Conference.: GMHC Treat Issues. 1996 Sep;10(9):7, 10-1. Unique Identifier : AIDSLINE AIDS/96701934; Torres G; The AIDS Society Treatment Guidelines came under scrutiny at the XI International AIDS Conference in Vancouver in 1996. The review panel agreed that treatment needs to be initiated before irreversible immunologic damage occurs. The types of drugs to use for initial therapy (
Police raid buyers' club.: GMHC Treat Issues. 1996 Sep;10(9):8. Unique Identifier : AIDSLINE AIDS/96701935; Police raided the Cannabis Buyers Club and confiscated the club s supply of pure marijuana and drug-laced baked goods. Although the club s purpose was to supply people with AIDS and cancer with marijuana, the California Attorney General s office says healthy people were being supplied as well. Many see the raid as a
CMV retinitis study aborted.: GMHC Treat Issues. 1996 Sep;10(9):8. Unique Identifier : AIDSLINE AIDS/96701936; A study of the experimental anti- cytomegalovirus ( CMV ) drug, MSL-109 manufactured by Protein Design Labs, was halted after an interim analysis found that the treatment offered no benefit over placebo, and that more deaths app
Anabolic steroid boosts weight.: GMHC Treat Issues. 1996 Sep;10(9):8-9. Unique Identifier : AIDSLINE AIDS/96701937; A randomized study of nandrolone decanoate (Deca-Durabolin) showed that the anabolic steroid can increase weight in people with HIV infections. The group receiving nandrolone experienced a greater increase both in fat-free mass and body cell mass (although the latter measure did not reach statistical significance) tha
Delavirdine/protease inhibitor interactions.: GMHC Treat Issues. 1996 Sep;10(9):11-2. Unique Identifier : AIDSLINE AIDS/96701938; Gilden D; On September 27, 1996, the Food and Drug Administration s ( FDA ) Antiviral Drugs Advisory Committee meets to consider licensing the non-nucleoside reverse transcriptase inhibitor (NNRTI), delavirdine (
New York ADAP to cover new AIDS drugs plus viral load testing.: GMHC Treat Issues. 1996 Sep;10(9):12. Unique Identifier : AIDSLINE AIDS/96701939; Link D; New York State, for the first time and after massive grass-roots lobbying, committed millions of State tax dollars to the local AIDS Drug Assistance Program (ADAP). No State has been hit harder by AIDS than New York. As of September 1, 1996, ADAP began covering HIV prot
Antiretrovirals plus immunomodulators: didanosine/interferon-alpha combination shows promise.: NIAID AIDS Agenda. 1996 Jun;:8-9. Unique Identifier : AIDSLINE AIDS/96701943; Folkers G; Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) Clinical Center intramural AIDS program safely administered didanosine (ddI) and interferon-alpha (IFN-alpha) to selected patients for more than 4 years. The study enrolled 36 asymptomatic patients, divided into 12 groups. Each of the gr
Nurses' body fluid exposure reporting, HIV testing, and hepatitis B vaccination rates: before and after implementing universal precautions regulations.: AAOHN J. 1996 Mar;44(3):129-37. Unique Identifier : AIDSLINE MED/96380366; Ramsey PW; Glenn LL; College of Nursing, East Tennessee State University, Johnson; City, USA.; The purpose of this study was to investigate whether mandatory universal precautions changed nurses body fluid exposure and reporting rates, hepatitis B vaccination rates, and human immunodeficiency virus (HIV) testing rates. Random cross-sectional surveys of nurses in Tennessee were conducted in 1991 and 1993 (n = 1
Non-nucleoside anti-HIV-1 reverse transcriptase inhibitors (NNRTIs): a chemical survey from lead compounds to selected drugs for clinical trials.: Farmaco. 1996 May;51(5):305-31. Unique Identifier : AIDSLINE MED/96276270; Artico M; Istituto di Microbiologia, Facolta di Farmacia, Universita di; Roma, La Sapienza, Italy.
Synthesis and antirhinovirus activity of 3-(diethylamino)-5-phenylisoxazole derivatives.: Farmaco. 1996 May;51(5):351-9. Unique Identifier : AIDSLINE MED/96276273; Mazzei M; Garzoglio R; Balbi A; Grandi T; De Montis A; Corrias S; La Colla P; Istituto di Scienze Farmaceutiche, Universita di Genova, Italy.; Previous studies showed that some 2 -alkyloxyisoxazoles 2b-d obtained from 3-(diethylamino)-5-(2 hydroxy-4 -methoxyphenyl)isoxazole 2a were endowed with an interesting anti-group B rhinovirus activity (action on HRV-2 serotype). Other isoxazoles (WIN compounds) are well known to have anti-group A rhinovirus activity (
Synthesis of substituted quinazolone derivatives as potential anti-HIV agents (Part III).: Farmaco. 1996 May;51(5):361-6. Unique Identifier : AIDSLINE MED/96276274; Desai NC; Bhatt JJ; Shah BR; Undavia NK; Trivedi PB; Narayanan V; Department of Chemistry, Bhavnagar University, India.; Several 1-[2-phenyl-4(4H)-oxo-3-quinazolinyl]-2-methyl-4-arylidine 5-oxo-imidazolines (Va-1), 2-phenyl-3-(aroyl amino)-4(4H)-oxo quinazolines (Vla-I) and N1-2-methyl-4(4H)-oxo-3-quinazolinyl-N2-aryl-thioureas (Vlla-k), have been synthesised and tested for anti-HIV activity. The structures of these compounds have been
Synthesis and anti-HIV activity of 10,11-dihydropyrrolo [1,2-b][1,2,5]benzothiadiazepine-11-acetic acid 5,5-dioxide derivatives and related compounds.: Farmaco. 1996 Jun;51(6):425-30. Unique Identifier : AIDSLINE MED/96305743; Silvestri R; Artico M; Pagnozzi E; Stefancich G; Massa S; La Colla P; Loi AG; Spiga MG; Corrias S; Lichino D; Dipartimento di Studi Farmaceutici, Universita di Roma La; Sapienza, Italy.; The synthesis and the in vitro anti-HIV-1 activity of novel pyrrolo annulated benzothiadiazepine acetic acids and some related derivatives are reported. The new compounds share chemical features with pyrrolo[1,2-d][1,4]benzodiazepin-6-one 1 and Ro 5-3335 pyrrylbenzodiazepinone 4, two inhibitors of HIV-replication at t
Evidence that Th1 lymphocytes predominate in islet inflammation and thyroiditis in the BioBreeding (BB) rat.: J Autoimmun. 1996 Jun;9(3):315-9. Unique Identifier : AIDSLINE MED/96413831; Zipris D; Diabetes Division, University of Massachusetts Medical Center,; Worcester 01605, USA.; Th1 cytokines are thought to play a key role in islet inflammation and destruction in insulin-dependent diabetes mellitus (IDDM). We studied this hypothesis in the diabetes-prone (DP)-BB and the diabetes-resistant (DR)-BB rats that are used as a model of human IDDM. The DP-BB rat develops spontaneous autoimmune diabet
Antigen based therapies to prevent diabetes in NOD mice.: J Autoimmun. 1996 Jun;9(3):349-56. Unique Identifier : AIDSLINE MED/96413835; Ramiya VK; Shang XZ; Pharis PG; Wasserfall CH; Stabler TV; Muir AB; Schatz DA; Maclaren NK; Department of Pathology and Laboratory Medicine, University of; Florida, Gainesville 32610-0275, USA.; Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that
Correlation between viral load measurements and outcome in clinical trials of antiviral drugs.: AIDS. 1995 Dec;9 Suppl 2:S15-S19. Unique Identifier : AIDSLINE MED/96371979; Schooley RT; Infectious Diseases Division, University of Colorado, Denver,; USA.; BACKGROUND: As evidence is emerging that viral load can be correlated with clinical outcome in HIV-infected patients, new assays have been developed to measure viral load in vivo. These include biological assays that involve assessment of viral load by limiting dilution cultures of plasma or peripheral blood mononucle
Clinical experience with saquinavir.: AIDS. 1995 Dec;9 Suppl 2:S21-S25. Unique Identifier : AIDSLINE MED/96371980; Vella S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; BACKGROUND: Saquinavir, a peptide-based, transition-state analogue of a characteristic HIV proteinase cleavage site, is a potent and highly specific inhibitor of HIV-1 and HIV-2 proteinases. COMBINATION THERAPY: Combination therapy with saquinavir at 600 mg and zidovudine at 200 mg, both three times a day, has been sh
Management of cytomegalovirus disease.: AIDS. 1995 Dec;9 Suppl 2:S3-S8. Unique Identifier : AIDSLINE MED/96371977; Danner SA; Academic Medical Centre, Amsterdam, Netherlands.; AIM: To review the estimated incidence of cytomegalovirus ( CMV ) disease, its diagnosis and currently accepted treatments and those under investigation. CMV DISEASE IN PATIENTS WITH HIV INFECTION: The most frequently occurring
Haematopoietic growth factors as supportive therapy in HIV-infected patients.: AIDS. 1995 Dec;9 Suppl 2:S9-S14. Unique Identifier : AIDSLINE MED/96371978; Hermans P; Saint Pierre Hospital, Brussels, Belgium.; BACKGROUND: Neutropenia and anaemia are common problems in patients with HIV infection. Neutropenia can lead to a reduction in drug doses or to withdrawal of important myelosuppressive agents such as ganciclovir, zidovudine, cotrimoxazole and pyrimethamine, while anaemia may require the administration of blood transfu
Drug-resistance patterns of saquinavir and other HIV proteinase inhibitors.: AIDS. 1995 Dec;9 Suppl 2:27-S32. Unique Identifier : AIDSLINE MED/96371981; Roberts NA; Roche Products Ltd, Welwyn Garden City, UK.; AIM: To review available drug-resistance patterns of HIV proteinase inhibitors, in particular saquinavir (formerly known as Ro 31-8959), focusing on the implications for disease management. RESULTS: Reduced sensitivity to saquinavir appears to develop slowly and at low frequency even during prolonged therapy, with an
A benzoic acid glycoside from Geniostoma antherotrichum.: Phytochemistry. 1996 Mar;41(4):1205-7. Unique Identifier : AIDSLINE MED/96351896; Rashid MA; Gustafson KR; Cardellina JH 2nd; Boyd MR; Laboratory of Drug Discovery Research and Development, National; Cancer Institute, Frederick, MD 21702-1201, USA.; Fractionation of an HIV-inhibitory organic extract of Geniostoma antherotrichum afforded a glycoside derivative, which has been characterized as 2-hydroxy-3-O-beta-D-glucopyranosyl-benzoic acid (1) on the basis of spectral analyses. The HIV-inhibitory activity of the extract was traced to polymeric tannins, while 1 wa
Selection and evolution of high-affinity human anti-viral antibodies.: Trends Biotechnol. 1996 Jul;14(7):230-4. Unique Identifier : AIDSLINE MED/96367681; Barbas CF 3rd; Burton DR; Department of Molecular Biology, Scripps Research Institute, La; Jolla, CA 92037, USA.; High-affinity human anti-viral antibodies [e.g. for human immunodeficiency virus type 1 (HIV-1), respiratory syncytial virus (RSV) and herpes simplex virus (HSV)] can be selected from immune phage-display libraries using a variety of strategies. A small subset of these antibodies show potent neutralization in vitro an
[HIV and hepatitis virus infections among prisoners and Police Forces in Rieti District, Italy]: Ann Ig. 1996 Mar-Apr;8(2):291-5. Unique Identifier : AIDSLINE MED/96300712; Bonaventura ME; Marchili M; di Nardo V; Div. Malattie Infettive, Azienda USL Rieti, Ospedale Generale; Provinciale di Rieti.
Extent of undiagnosed HIV infection in hospitalized patients: assessment by linkage of seroprevalence and surveillance methods.: Am J Prev Med. 1996 May-Jun;12(3):195-202. Unique Identifier : AIDSLINE MED/96363820; Trepka MJ; Davidson AJ; Douglas JM Jr; Department of Preventive Medicine University of Colorado Health; Sciences Center, USA.; Routine screening of hospitalized patients for human immunodeficiency virus (HIV) infection has been suggested as a method to identify undiagnosed HIV infection. To evaluate HIV seroprevalence and rates and risk factors for undiagnosed HIV infection among inpatients at an urban hospital, we linked a blinded HIV seropr
HIV sexual risk reduction interventions for women: a review.: Am J Prev Med. 1996 May-Jun;12(3):209-17. Unique Identifier : AIDSLINE MED/96363822; Wingood GM; DiClemente RJ; Department of Health Behavior, School of Public Health,; University of Alabama, Birmingham 35294-2010, USA.; AIDS has emerged as a serious public health threat for women. Reducing the risk for HIV infection among sexually active women requires the adoption of preventive strategies that effectively inhibit viral transmission. However, there is a paucity of published literature describing interventions targeted toward women an
Survival after paraquat poisoning in a HIV positive patient.: Hum Exp Toxicol. 1996 Apr;15(4):286-8. Unique Identifier : AIDSLINE MED/96271964; Ragoucy-Sengler C; Pileire B; Laboratoire de Biochimie-Pharmacologie-Toxicologie, Centre; Hospitalier Regional et Universitaire, Pointe a Pitre,; Guadeloupe FWI.; From 1987 to 1994, 31 cases of acute paraquat poisoning were managed in the CHRU of Pointe a Pitre (FWI). Eighteen patients died, 13 survived. Biological indexes accurately predicted patient s outcome in all cases out of one. In the last case biological parameters were misleading: the corresponding patient survived de
AIDS-related non-Hodgkin's lymphoma presenting as delayed healing of an extraction wound.: Br Dent J. 1996 Aug 10;181(3):102-4. Unique Identifier : AIDSLINE MED/96405985; Nittayananta W; Chungpanich S; Pongpanich S; Mitarnun W; Department of Stomatology, Faculty of Dentistry, Prince of; Songkla University, Thailand.; Non-Hodgkin s lymphoma (NHL) of the oral cavity frequently occurs in patients infected with human immunodeficiency virus (HIV). This report describes a lesion presenting as delayed healing of an extraction wound with hyperaemic swollen gingivae and ulceration in an apparently healthy 34-year-old Thai fisherman. The le
Mucocutaneous manifestations in 22 consecutive cases of primary HIV-1 infection.: Br J Dermatol. 1996 Feb;134(2):257-61. Unique Identifier : AIDSLINE MED/96362624; Lapins J; Lindback S; Lidbrink P; Biberfeld P; Emtestam L; Gaines H; Department of Dermato-Venereology, Huddinge Hospital, Sweden.; Twenty-two consecutive patients presenting with symptomatic human immunodeficiency virus 1 (HIV-1) seroconversion were studied. Most of the patients had a glandular fever-like illness. All patients had fever and pharyngitis, and eight of them also suffered from ulcers of the oral, genital or anal mucosa. Uniform skin
Low incidence of Epstein-Barr virus presence in primary cutaneous T-cell lymphoproliferations.: Br J Dermatol. 1996 Feb;134(2):276-81. Unique Identifier : AIDSLINE MED/96362627; Anagnostopoulos I; Hummel M; Kaudewitz P; Korbjuhn P; Leoncini L; Stein H; Klinikum Benjamin Franklin, Free University Berlin, Germany.; Multiple biopsies taken from 76 European human immunodeficiency virus (HIV)-negative patients with primary cutaneous T-cell lymphoproliferations, including mycosis fungoides (MF), pleomorphic T-cell lymphoma (PMTCL), anaplastic large cell lymphoma (ALCL) and lymphomatoid papulosis (LyP) were investigated for the prese
No detection of HTLV-I proviral DNA in lesional skin biopsies from Swiss and German patients with cutaneous T-cell lymphoma.: Br J Dermatol. 1996 Feb;134(2):282-4. Unique Identifier : AIDSLINE MED/96362628; Boni R; Davis-Daneshfar A; Burg G; Fuchs D; Wood GS; Department of Dermatology, University Hospital of Zurich,; Switzerland.; The search for an infective agent linked to cutaneous T-cell lymphoma (CTCL) has also included the human T-cell lymphotropic virus type I (HTLV-I). Using sensitive techniques such as Southern blotting under low stringency conditions of hybridization and polymerase chain reaction (PCR) with primer sets designed to matc
Fingertip necrosis during chemotherapy with bleomycin, vincristine and methotrexate for HIV-related Kaposi's sarcoma [letter]: Br J Dermatol. 1996 Feb;134(2):378-9. Unique Identifier : AIDSLINE MED/96362655; Pechere M; Zulian GB; Vogel JJ; Jeanpretre M; Hirschel B; Saurat JH
Emergence of CD52-, glycosylphosphatidylinositol-anchor-deficient lymphocytes in rheumatoid arthritis patients following Campath-1H treatment.: Int Immunol. 1996 Mar;8(3):325-34. Unique Identifier : AIDSLINE MED/96362207; Brett SJ; Baxter G; Cooper H; Rowan W; Regan T; Tite J; Rapson N; Molecular Immunology Group, Wellcome Research Laboratories, Kent,; UK.; CD52 is a glycosylphosphatidyl-inositol (GPI)-linked glycoprotein expressed at high levels on normal T and B lymphocytes and at lower levels on monocytes, while being absent on granulocytes and bone marrow stem cell precursors. The emergence of CD52- lymphocytes of both T and B cell lineages was observed in three out
Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo.: Int Immunol. 1996 Mar;8(3):335-42. Unique Identifier : AIDSLINE MED/96362208; Hoyne GF; Askonas BA; Hetzel C; Thomas WR; Lamb JR; Department of Biology, Imperial College of Science, Technology; and Medicine, London, UK.; We have previously demonstrated that intranasal (i.n.) administration of an immunodominant peptide (p1-111-139) derived from the house dust mite (HDM) allergen Der p 1 inhibits antigen-specific CD4+ T cell responses in H-2b mice. Here we report that i.n. peptide induced a rapid but transient activation of MHC class II
Effects of different antigenic microenvironments on the course of CD8+ T cell responses in vivo.: Int Immunol. 1996 Mar;8(3):351-8. Unique Identifier : AIDSLINE MED/96362210; Tarazona R; Sponaas Georgia AM; Zhou MM; Schulz R; Tomlinson P; Antoniou J; Mellor AL; Division of Molecular Immunology, National Institute for Medcial; Research, London, UK.; The influence of microenvironment on the course of CD8 + T cell responses in vivo was investigated by injecting H-2Kb-specific T cells from donor TCR transgenic (TCR-Tg) mice into H-2kb-Tg mice. H-2Kb expression in recipients was either ubiquitous (CBK mice) or restricted to myeloid and erythroid cells (K beta mice).
H2-M3wt-restricted, Listeria monocytogenes-specific CD8 T cells recognize a novel, hydrophobic, protease-resistant, periodate-sensitive antigen.: Int Immunol. 1996 Mar;8(3):367-78. Unique Identifier : AIDSLINE MED/96362212; Nataraj C; Brown ML; Poston RM; Shawar SM; Rich RR; Lindahl KF; Kurlander RJ; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.; Mice infected with Listeria monocytogenes (LM) generate H2-M3wt-restricted CD8 effectors which recognize a heat-killed LM-associated antigen (HAA) presented by macrophages. To characterize HAA, we extracted a bioactive component from LM using SDS or NaOH. Extracted HAA aggregated in hydrophilic solvents but dissociate
Evaluation of presence and functional activity of potentially self-reactive T cells in aged mice.: Int Immunol. 1996 Mar;8(3):387-95. Unique Identifier : AIDSLINE MED/96362214; Crisi GM; Tsiagbe VK; Russo C; Basch RS; Thorbecke GJ; Department of Pathology and Kaplan Cancer Center, New York; University School of Medicine, NY 10016, USA.; Autoimmunity is known to increase in aging. A possible factor could be an alteration in the T cell repertoire with advancing age. Antibodies to the variable region of the beta chain of the TCR activate T cells and can serve as probes for analysis of the T cell repertoire. We have used V beta 3 and V beta 17a antibodie
In vitro and in vivo recovery of IFN-gamma, but not IL-2, production by IL-12 in mice with plasma cell tumors.: Int Immunol. 1996 Mar;8(3):413-22. Unique Identifier : AIDSLINE MED/96362217; Ruzek MC; Mathur A; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA.; We have previously found that T cells from mice bearing plasma cell tumors (PCT mice) demonstrate decreased proliferation as well as decreased production of the Th 1-associated cytokines IL-2 and IFN-gamma in response to polyclonal stimulation. In the present study, weo
Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases.: Biochemistry. 1995 Dec 19;34(50):16337-46. Unique Identifier : AIDSLINE MED/96110711; Divita G; Rittinger K; Restle T; Immendorfer U; Goody RS; Max-Planck-Institut fur Medizinische Forschung, Abteilung; Biophysik, Heidelberg, Germany.; The dissociation of dimeric reverse transcriptase (RT) of the human immunodeficiency virus (HIV) types 1 and 2 has been investigated using acetonitrile as a dissociating agent. The equilibrium transitions were monitored by combining different approaches (fluorescence spectroscopy, polymerase activity assay, and size-eo
Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase.: Biochemistry. 1996 Sep 10;35(36):11536-46. Unique Identifier : AIDSLINE MED/96387193; Kaushik N; Rege N; Yadav PN; Sarafianos SG; Modak MJ; Pandey VN; Department of Biochemistry and Molecular Biology, UMD-New Jersey; Medical School, Newark 07103, USA.; In order to clarify the role(s) of the individual member of the carboxylate triad in the catalytic mechanism of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, we carried out site-directed mutagenesis of D185, D186, and D110, followed by the extensive characterization of the properties of the indivio
Deoxyadenosine-based DNA polymerase photoprobes: design, synthesis, and characterization as inhibitors of the Escherichia coli DNA polymerase I Klenow fragment.: Biochemistry. 1996 Sep 10;35(36):11634-41. Unique Identifier : AIDSLINE MED/96387203; Moore BM 2nd; Li K; Doughty MB; Department of Medicinal Chemistry, University of Kansas, Lawrence; 66045, USA.; DNA polymerase photoprobes 2-[(4-azidophenacyl)thio]-2 -deoxyadenosine 5 -triphosphate (1), 2-[(4-azidophenylsulfenyl)thio]-2 -deoxyadenosine 5 -triphosphate (2), and 2-[(4-azido-2-nitrophenyl)-thio]-2 -deoxyadenosine 5 -triphosphate (3) were designed from a thermodynamic model of DNA polymerase 1-substrate interactioo
Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme.: Biochemistry. 1996 Sep 10;35(36):11693-701. Unique Identifier : AIDSLINE MED/96387210; Raillard SA; Joyce GF; Department of Chemistry, Scripps Research Institute, La Jolla,; California 92037, USA.; A variant of the Tetrahymena ribozyme that efficiently cleaves single-stranded DNA under simulated physiological conditions [Tsang, J., & Joyce, G. F. (1994) Biochemistry 33, 5966-5973] was evaluated as a potential therapeutic agent on the basis of its ability to cleave synthetic oligonucleotide substrates correspo
Incorporation of an artificial protease and nuclease at the HIV-1 Tat binding site of trans-activation responsive RNA.: Bioconjug Chem. 1996 May-Jun;7(3):283-9. Unique Identifier : AIDSLINE MED/96413814; Shah K; Neenhold H; Wang Z; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical; School-UMDNJ, New Jersey 08854, USA.; The synthesis of a C-5 modified uridine phosphoramidite which contains a primary amino group protected with Fmoc is described. During cleavage and deprotection of chemically synthesized RNA, the Fmoc protecting group is removed to yield a free amino group at a predetermined position in the RNA sequence that can be cov
Dystrophin expression in muscles of mdx mice after adenovirus-mediated in vivo gene transfer.: Hum Gene Ther. 1996 Jan 20;7(2):129-40. Unique Identifier : AIDSLINE MED/96380151; Acsadi G; Lochmuller H; Jani A; Huard J; Massie B; Prescott S; Simoneau M; Petrof BJ; Karpati G; Montreal Neurological Institute, McGill University, Canada.; We have generated high-titer adenoviral recombinants (AVR) expressing a 6.3-kb partial dystrophin cDNA insert under the control of either the Rous sarcoma virus (RSV) or cytomegalovirus ( CMV ) promoter. These AVR preparations
Women, contraception and STDs including HIV [editorial]: Int J STD AIDS. 1995 Nov-Dec;6(6):373-86. Unique Identifier : AIDSLINE MED/96256037; Carlin EM; Boag FC; It is estimated that eight million women are infected with the human immunodeficiency virus (HIV) worldwide. Heterosexual transmission is the predominant mode of HIV transmission on a global basis and is becoming increasingly important in the Western world. Women have long used contraceptives as a means of protection
HIV in UK prisons: a review of seroprevalence, transmission and patterns of risk [editorial]: Int J STD AIDS. 1995 Nov-Dec;6(6):387-91. Unique Identifier : AIDSLINE MED/96256038; Curtis SP; Edwards A; Prisons contain individuals at high risk of HIV infection, notably through intravenous drug use. For complex political, social and legal reasons penal institutions in the UK are unable to provide condoms and clean needles. The outbreak of HIV and hepatitis B that occurred in a Scottish prison in 1993 focused attention
Patients misrepresenting their risk factors for AIDS [editorial]: Int J STD AIDS. 1995 Nov-Dec;6(6):392-8. Unique Identifier : AIDSLINE MED/96256039; Brody S; To determine the truthfulness of patients and research subjects self-reports of their sexual and drug use histories in studies of human immunodeficiency virus (HIV) transmission and acquired immunodeficiency syndrome (AIDS) risk factors, studies of or pertinent to lying about AIDS risk factors were extracted from ME
Medical therapy of genital human papilloma virus-related disease.: Int J STD AIDS. 1995 Nov-Dec;6(6):399-407. Unique Identifier : AIDSLINE MED/96256040; Lacey CJ; Fairley I; Department of Genitourinary Medicine, General Infirmary, Leeds,; UK.
Management of mycoses associated with HIV disease.: Int J STD AIDS. 1995 Nov-Dec;6(6):408-12. Unique Identifier : AIDSLINE MED/96256041; Coker RJ; Fisher M; Tomlinson DR; Department of Genitourinary Medicine, St Mary's Hospital, London,; UK.
The case for early intervention ('see and treat') in patients with dyskaryosis on routine cervical screening.: Int J STD AIDS. 1995 Nov-Dec;6(6):415-7. Unique Identifier : AIDSLINE MED/96256042; Murdoch JB; Directorate of Obstetrics, Gynaecology and ENT, St Michael's; Hospital, Bristol, UK.; See and treat colposcopy using an excisional technique (usually LLETZ) is very attractive to patients and practitioners. It is therapeutically effective, efficient and cost-effective within the context of the screening programme. It is, of course, inappropriate to excise the transformation zone of any woman who atte
The case for selective 'see and treat' in patients referred for colposcopy.: Int J STD AIDS. 1995 Nov-Dec;6(6):418-21. Unique Identifier : AIDSLINE MED/96256043; Gardeil F; Turner MJ; Coombe Women's Hospital, Dublin, Ireland.
Chlamydia trachomatis as a possible cofactor for Kaposi's sarcoma in AIDS.: Int J STD AIDS. 1995 Nov-Dec;6(6):422-5. Unique Identifier : AIDSLINE MED/96256044; Peters BS; Thomas BJ; Yi C; Beck EJ; Weber J; Pinching AJ; Taylor-Robinson D; Department of Genitourinary Medicine and Communicable Diseases,; St Mary's Hospital Medical School, London, UK.; AIDS-associated Kaposi s sarcoma (KS) is much more frequent in patients acquiring HIV infection via the sexual route. Epidemiological studies have confirmed the likely involvement of a sexually acquired cofactor in the pathogenesis of this form of KS. We have formulated a set of postulates, epidemiological and experim
Preoperative HIV antibody testing: the views of surgeons and patients.: Int J STD AIDS. 1995 Nov-Dec;6(6):426-30. Unique Identifier : AIDSLINE MED/96256045; Meadows J; Irving G; Chapman K; Gazzard B; Catalan J; Psychological Medicine Unit, Chelsea & Westminster Hospital,; London, UK.; Fifty surgeons and 72 preoperative patients in 2 central London hospitals were asked their views on preoperative HIV antibody testing, who is at risk of HIV infection and HIV test counseling. A substantial proportion of both surgeons and preoperative patients, 48% and 54% respectively, supported compulsory HIV antibod
Multicentre clinical trial with herpes simplex virus vaccine in recurrent herpes infection.: Int J STD AIDS. 1995 Nov-Dec;6(6):431-5. Unique Identifier : AIDSLINE MED/96256046; Mastrolorenzo A; Tiradritti L; Salimbeni L; Zuccati G; Department of Dermatology, STD & AIDS Center, University of; Florence, Italy.; The aim of this work was to confirm our preliminary clinical and immunological evaluation of the protective effects of a herpes simplex virus (HSV) vaccine derived from killed virus in the treatment of relapsing facial or genital herpes simplex infection. A total of 142 patients
Psychosocial differences between recently HIV tested and non-tested gay men who reside in smaller US cities.: Int J STD AIDS. 1995 Nov-Dec;6(6):436-40. Unique Identifier : AIDSLINE MED/96256047; Heckman TG; Kelly JA; Roffman RA; Sikkema KJ; Perry MJ; Solomon LJ; Winett RA; Norman AD; Hoffmann RG; Stevenson LY; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA.; While a number of studies have examined behavioural and psychosocial correlates of HIV test seeking, most of this research has relied on samples of urban gay men. Less is known about HIV testing rates and factors associated with testing among gay and bisexual men who live in smaller cities. The present research admini
Prevalence of blood-borne viruses among intravenous drug users and alcoholics in Hiroshima, Japan.: Int J STD AIDS. 1995 Nov-Dec;6(6):441-3. Unique Identifier : AIDSLINE MED/96256048; Ichimura H; Kurimura O; Tamura I; Tsukue I; Tsuchie H; Kurimura T; Institute of Clinical Research, Kure National Hospital,; Hiroshima, Japan.; We investigated the prevalence of human immunodeficiency viruses-1 and 2 (HIV-1 and HIV-2), human T-lymphotropic virus type I and II, hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus among intravenous drug users (IVDU) in Hiroshima, Japan , where little is known
Lifetime cost of treating a person with HIV infection.: Int J STD AIDS. 1995 Nov-Dec;6(6):444-6. Unique Identifier : AIDSLINE MED/96256049; Jebakumar SP; Woolley PD; Curless E; Department of GU Medicine, University Hospital of South; Manchester, UK.; A study was conducted to examine the inpatient, outpatient and drug therapy costs incurred from initial presentation with HIV infection or AIDS to death, where death occurred between 1990 and 1994. The average lifetime cost per patient was 18,729 pounds being made up of 8428 pounds for inpatient care, 2086 pounds for
Spectrum of opportunistic infections among AIDS patients in Tamil Nadu, India.: Int J STD AIDS. 1995 Nov-Dec;6(6):447-9. Unique Identifier : AIDSLINE MED/96256050; Kumarasamy N; Solomon S; Jayaker Paul SA; Venilla R; Amalraj RE; Government General Hospital, Madras, India.; A retrospective case note review of 100 AIDS patients attending a large Indian centre was performed. Of these 100 patients, 94% gave a history of heterosexual HIV transmission, 68% were male. The majority of females were aged 21 to 30 years. The most common mode of presentation was tuberculosis (61%), both pulmonary (
Erythema multiforme secondary to dideoxycytidine (ddC).: Int J STD AIDS. 1995 Nov-Dec;6(6):450. Unique Identifier : AIDSLINE MED/96256051; Wardropper AG; Ong EL; Department of Genitourinary Medicine, Newcastle General Hospital,; Newcastle upon Tyne, UK.
Phthirus pubis infestation of the eyelids: a marker for sexually transmitted diseases.: Int J STD AIDS. 1995 Nov-Dec;6(6):451-2. Unique Identifier : AIDSLINE MED/96256052; Skinner CJ; Viswalingam ND; Goh BT; Royal Hospitals Trust, London, UK.
The value of an additional diagnostic test for first attacks of genital herpes.: Int J STD AIDS. 1995 Nov-Dec;6(6):453. Unique Identifier : AIDSLINE MED/96256053; Watson PG; Pattman RS; Sankar KN; Wardropper AG; Department of Genitourinary Medicine, Newcastle General Hospital,; Newcastle upon Tyne, UK.
Successful prevention of recurrent pneumonia caused by Pseudomonas aeruginosa in a patient with AIDS [letter]: Int J STD AIDS. 1995 Nov-Dec;6(6):454-5. Unique Identifier : AIDSLINE MED/96256054; Ainsworth J
The use of central venous catheters in patients with HIV [letter]: Int J STD AIDS. 1995 Nov-Dec;6(6):455-6. Unique Identifier : AIDSLINE MED/96256055; Dimian CO; Bingham JS
HIV prevalence among blood donors correlates with hospital STD rate in Maharashtra, India [letter]: Int J STD AIDS. 1995 Nov-Dec;6(6):456. Unique Identifier : AIDSLINE MED/96256056; Salunke SR; Jagtap MR; Hira SK
Chlamydia trachomatis prevalence in high risk women, Tijuana, Mexico, 1993--a pilot study [letter]: Int J STD AIDS. 1995 Nov-Dec;6(6):456-8. Unique Identifier : AIDSLINE MED/96256057; Gunn RA; Valdez Oropeza E; Santaella A; Peter CR
Fellatio in the sexual transmission of Lancefield Group A beta-haemolytic streptococcus [letter]: Int J STD AIDS. 1995 Nov-Dec;6(6):458. Unique Identifier : AIDSLINE MED/96256058; Fisk P; Riley V
Quantification of zidovudine and individual zidovudine phosphates in peripheral blood mononuclear cells by a combined isocratic high performance liquid chromatography radioimmunoassay method.: J Pharm Biomed Anal. 1996 Feb;14(4):491-9. Unique Identifier : AIDSLINE MED/96362400; Peter K; Lalezari JP; Gambertoglio JG; Division of Clinical Pharmacy, University of California, San; Francisco 94143-0622, USA.; Zidovudine (ZDV, AZT ) is the first clinically effective drug licensed for use in the treatment of human immunodeficiency virus (HIV) infection. Activation of ZDV requires phosphorylation to ZDV triphosphate by cellular kinases. It is important, theref
Aborigines and tuberculosis: why they are at risk.: Aust J Public Health. 1995 Oct;19(5):487-91. Unique Identifier : AIDSLINE MED/96342472; Plant AJ; Krause VL; Condon JR; Kerr C; National Centre for Epidemiology and Population Health,; Australian National University, Canberra.; Aborigines have higher rates of Mycobacterium tuberculosis than the rest of the community. There are insufficient contemporary data to assess how much risk tuberculosis poses to the Aboriginal community. Tuberculosis is of particular concern because of its interaction with human immuno-deficiency virus (HIV). We aimed
Infection control and human immunodeficiency virus: perceptions of risk among nurses and hospital domestic workers.: Aust J Public Health. 1995 Oct;19(5):492-500. Unique Identifier : AIDSLINE MED/96342473; Parsons CD; Spicer MJ; Richardson M; Peterson C; Watson LF; Centre for Research in Public Health and Nursing, La Trobe; University, Melbourne.; In December 1993 the first case of patient-to-patient transmission of human immunodeficiency virus (HIV), at a doctor s surgery in New South Wales, was documented. In an environment of heightened anxiety about HIV transmission and the adequacy of infection-control measures taken by health providers, it is important to
[Expression of HIV-1 epitopes included in particles formed by human hepatitis B virus nucleocapsid protein]: Biokhimiia. 1996 Mar;61(3):532-45. Unique Identifier : AIDSLINE MED/96319939; Isaguliants MG; Kadoshnikov IuP; Kalinina TI; Khuliakov IuE; Semiletov IuA; Smirnov VD; Wahren B; Swedish Institute for Infectious Disease Control, Stockholm,; Sweden.; Hybrids of the core protein of hepatitis B virus (HBcAg) have been designed which carry N-terminal insertions of B- and T-cell epitopes of HIV-1 an immunodominant B-epitope from gp41, a T-cell epitope from p34 pol, and a cluster of B- and T-cell epitopes from p17 gag. The hybrids have been synthesized using two expres
Clinical significance of drug resistance in human immunodeficiency virus.: Clin Infect Dis. 1995 Oct;21 Suppl 2:S166-9. Unique Identifier : AIDSLINE MED/96114198; Richman DD; Department of Pathology, Department of Veterans Affairs Medical; Center, San Diego, California, USA.; Antiretroviral drugs exert only limited activity against viruses that replicate persistently to high levels. Thus, drug-resistant viruses readily emerge. It has been difficult to assess the contribution of such drug resistance to the failure of treatment with drugs that have only limited effectiveness in the first pla
Molecular detection of human cytomegalovirus and determination of genotypic ganciclovir resistance in clinical specimens.: Clin Infect Dis. 1995 Oct;21 Suppl 2:S170-3. Unique Identifier : AIDSLINE MED/96114199; Spector SA; Hsia K; Wolf D; Shinkai M; Smith I; Department of Pediatrics, University of California, San Diego, La; Jolla 92093-0672, USA.; The data presented in this article demonstrate how the polymerase chain reaction (PCR) can be used to detect human cytomegalovirus (HCMV) DNA in the plasma and cerebrospinal fluid (CSF) of infected individuals. Detection of HCMV DNA in plasma of transplant recipients and persons in
Clinical impact of cytomegalovirus infections of the nervous system in patients with AIDS.: Clin Infect Dis. 1995 Oct;21 Suppl 2:S196-201. Unique Identifier : AIDSLINE MED/96114205; McCutchan JA; Department of Medicine, University of California, San Diego, USA.; Cytomegalovirus ( CMV ) causes five distinct neurological syndromes in patients with AIDS: retinitis, myelitis/polyradiculopathy, encephalitis with dementia , ventriculoencephalitis, and mononeuritis multiplex. The clinical synd
Cytomegalovirus-induced alveolar hemorrhage in patients with AIDS: a new clinical entity?: Clin Infect Dis. 1996 Apr;22(4):616-20. Unique Identifier : AIDSLINE MED/96362427; Herry I; Cadranel J; Antoine M; Meharzi J; Michelson S; Parrot A; Rozenbaum W; Mayaud C; Service de Pneumologie, Hopital Tenon, Paris, France.; We report five cases of alveolar hemorrhage associated with intravascular hemolysis in patients with AIDS. Cytomegalovirus was the only pathogen recovered from the lungs of these patients. There was evidence of multivisceral spread of the virus in all patients, and all had viremia. All had clinical, biological, and pa
AIDS-associated cytomegalovirus infection mimicking central nervous system tumors: a diagnostic challenge.: Clin Infect Dis. 1996 Apr;22(4):626-31. Unique Identifier : AIDSLINE MED/96362429; Moulignier A; Mikol J; Gonzalez-Canali G; Polivka M; Pialoux G; Welker Y; Alain S; Thiebaut JB; Dupont B; Services des Maladies Infectieuses et tropicales, Hopital de; l'Institut Pasteur, Paris.; We reviewed cases of cytomegalovirus ( CMV ) infection of the central nervous system (CNS) that initially masqueraded as tumors in 37 of 543 consecutive patients infected with human immunodeficiency virus (HIV) and CMV who were
Infectious etiologies of rhabdomyolysis: three case reports and review.: Clin Infect Dis. 1996 Apr;22(4):642-9. Unique Identifier : AIDSLINE MED/96362432; Singh U; Scheld WM; Department of Internal Medicine, University of Virginia Health; Sciences Center, Charlottesville 22908, USA.; Rhabdomyolysis can be precipitated by trauma, ischemia, metabolic defects, electrolyte abnormalities, drugs, and a wide variety of infectious diseases. At our institution, recent cases of rhabdomyolysis induced by influenza prompted us to review the infectious etiologies of this entity. In addition, a thorough literat
Increased levels of nitrite in the sera of children infected with human immunodeficiency virus type 1.: Clin Infect Dis. 1996 Apr;22(4):650-3. Unique Identifier : AIDSLINE MED/96362433; Torre D; Ferrario G; Speranza F; Martegani R; Zeroli C; Division of Infectious Diseases, Regional Hospital, Varese,; Italy.; Nitric oxide (NO) is a newly discovered gas that plays an important role in cell communication and host resistance to infection. The production of NO was examined in the sera of seven children infected with human immunodeficiency virus type 1 (HIV-1) and in the sera of 14 children who became seronegative for HIV-1 dur
Cavitary pulmonary lesions in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Apr;22(4):671-82. Unique Identifier : AIDSLINE MED/96362436; Gallant JE; Ko AH; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287-6220, USA.; The differential diagnosis of cavitary pulmonary lesions in individuals infected with human immunodeficiency virus (HIV) is broad, especially in patients with advanced disease. In patients with Pneumocystis carinii pneumonia, cavitation is an uncommon manifestation of a common disease. It is unusual in patients with p
Tuberculosis in patients infected with human immunodeficiency virus: perspective on the past decade.: Clin Infect Dis. 1996 Apr;22(4):683-704. Unique Identifier : AIDSLINE MED/96362437; Shafer RW; Edlin BR; Division of Infectious Diseases and Geographic Medicine, Stanford; University Medical Center, California 94305, USA.; Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in persons infected with human immunodeficiency virus (HIV) worldwide. Because HIV is spreading in regions with the highest rates of Mycobacterium tuberculosis infection, HIV is responsible for an increasing proportion of the w
Rifabutin versus placebo in combination with three drugs in the treatment of nontuberculous mycobacterial infection in patients with AIDS.: Clin Infect Dis. 1996 Apr;22(4):705-8. Unique Identifier : AIDSLINE MED/96362438; Dautzenberg B; Olliaro P; Ruf B; Esposito R; Opravil M; Hoy JF; Rozenbaum W; Carosi GP; Micoud M; L'Age M; Pirotta N; Sassella D; Groupe Hospitalier Pitie-Salpetriere, Paris, France.; The aim of this double-blind, randomized, placebo-controlled, 12-week study was to assess the efficacy of rifabutin (450 or 600 mg/d) in the treatment of disseminated nontuberculous mycobacterial infection in patients with AIDS. Companion drugs in both arms of the study were ethambutol, clofazimine, and isoniazid. Bec
Unusual presentation of cryptococcosis in a patient with AIDS.: Clin Infect Dis. 1996 Apr;22(4):709. Unique Identifier : AIDSLINE MED/96362439; Finazzi R; Guffanti M; Cernuschi M; Erembourg L; Capasso G; Ossi C; Gesu G; Department of Infectious Diseases, Scientific Institute Ospedale; San Raffaele, Milan, Italy.
Helicobacter cinaedi bacteremia associated with localized pain but not with cellulitis.: Clin Infect Dis. 1996 Apr;22(4):710-11. Unique Identifier : AIDSLINE MED/96362441; van der Ven AJ; Kullberg BJ; Vandamme P; Meis JF; Department of General Internal Medicine, University Hospital; Nijmegen, Netherlands.
Rhodococcus equi mastoiditis in a patient with AIDS.: Clin Infect Dis. 1996 Apr;22(4):713. Unique Identifier : AIDSLINE MED/96362443; Lopes Cardoso FL; Machado ES; Souza MJ; Cunha R; Hospital dos Servidores do Estado, Rio de Janeiro, Brazil.
Effect of clarithromycin on the pharmacokinetics of 2',3'-dideoxyinosine in patients who are seropositive for human immunodeficiency virus.: Clin Infect Dis. 1996 Apr;22(4):716-8. Unique Identifier : AIDSLINE MED/96362446; Gillum JG; Bruzzese VL; Israel DS; Kaplowitz LG; Polk RE; Department of Pharmacy and Pharmaceutics, Medical College of; Virginia/Virginia Commonwealth University, Richmond, USA.
Symptomatic vulvovaginitis due to fluconazole-resistant Candida albicans in a female who was not infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Apr;22(4):726-7. Unique Identifier : AIDSLINE MED/96362453; Sobel JD; Vazquez JA; Department of Internal Medicine, Wayne State University School of; Medicine, Detroit, Michigan, USA.
Strongyloides stercoralis hyperinfection syndrome in a patient with AIDS: diagnosis by fluorescent microscopy.: Clin Infect Dis. 1996 Apr;22(4):736. Unique Identifier : AIDSLINE MED/96362461; Nomura J; Rekrut K; Department of Internal Medicine, Kaiser Permanente Medical; Center, Los Angeles, California, USA.
Strongyloides stercoralis first-stage larvae in the lungs of a patient with AIDS: primary localization or a noninvasive form of dissemination?: Clin Infect Dis. 1996 Apr;22(4):737. Unique Identifier : AIDSLINE MED/96362462; Cirioni O; Giacometti A; Burzacchini F; Balducci M; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Italy.
Factors associated with the development of Pneumocystis carinii pneumonia [letter]: Clin Infect Dis. 1996 Apr;22(4):738-9. Unique Identifier : AIDSLINE MED/96362463; Hoover DR
Toxoplasmosis localized to the bladder is diagnostic of human immunodeficiency virus infection: case report [letter]: Clin Infect Dis. 1996 Apr;22(4):740-1. Unique Identifier : AIDSLINE MED/96362465; Chemlal K; Delmas V; Toublanc M; Carbon C; Yeni P
Bacillary angiomatosis and bacillary peliosis in patients infected with human immunodeficiency virus: clinical characteristics in a case-control study.: Clin Infect Dis. 1996 May;22(5):794-800. Unique Identifier : AIDSLINE MED/96309045; Mohle-Boetani JC; Koehler JE; Berger TG; LeBoit PE; Kemper CA; Reingold AL; Plikaytis BD; Wenger JD; Tappero JW; Childhood and Respiratory Disease Branch, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Clinical characteristics associated with bacillary angiomatosis and bacillary peliosis (BAP) in patients with human immunodeficiency virus (HIV) infection were evaluated in a case-control study; 42 case-patients and 84 controls were matched by clinical care institution. Case-
Bacillary angiomatosis and parenchymal peliosis: frequent absence of mucocutaneous lesions [editorial]: Clin Infect Dis. 1996 May;22(5):801-2. Unique Identifier : AIDSLINE MED/96309046; Schwartzman WA
Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown origin.: Clin Infect Dis. 1996 May;22(5):809-12. Unique Identifier : AIDSLINE MED/96309048; Falagas ME; Klempner MS; Department of Medicine, New England Medical Center, Boston,; Massachusetts 02111, USA.; Babesiosis is a malaria-like, tick-transmitted zoonosis caused by protozoa of the family Piroplasmorida, which includes Babesia and Theileria species. In the United States , the infection is endemic in the Northeast and upper Midwest, although cases have recently been described in North
Randomized controlled trial of a drug regimen that includes ciprofloxacin for the treatment of pulmonary tuberculosis.: Clin Infect Dis. 1996 May;22(5):827-33. Unique Identifier : AIDSLINE MED/96309052; Kennedy N; Berger L; Curram J; Fox R; Gutmann J; Kisyombe GM; Ngowi FI; Ramsay AR; Saruni AO; Sam N; Tillotson G; Uiso LO; Yates M; Gillespie SH; Department of Medical Microbiology, Royal Free Hospital School of; Medicine, London, United Kingdom.; The fluoroquinolones are promising new antituberculous agents. A randomized controlled trial of 200 adult patients with sputum smear-positive pulmonary tuberculosis was conducted in Tanzania . Patients received either a trial regimen (HRC) consisting of isoniazid (300 mg), rifampi
High-dose fluconazole therapy for cryptococcal meningitis in patients with AIDS.: Clin Infect Dis. 1996 May;22(5):838-40. Unique Identifier : AIDSLINE MED/96309054; Menichetti F; Fiorio M; Tosti A; Gatti G; Bruna Pasticci M; Miletich F; Marroni M; Bassetti D; Pauluzzi S; Institute of Infectious Diseases, University of Perugia, Italy.; Fluconazole (800-1,000 mg i.v.) was administered to 14 consecutive patients with AIDS and cryptococcal meningitis. At 10 weeks the rate of clinical success was 54.5% (six of 11 patients responded to fluconazole); the Kaplan-Meier estimate of the response rate was 67.1%, and the overall mortality rate was 18.2% (two of
Severe, protracted intestinal cryptosporidiosis associated with interferon gamma deficiency: pediatric case report.: Clin Infect Dis. 1996 May;22(5):848-50. Unique Identifier : AIDSLINE MED/96309057; Gomez Morales MA; Ausiello CM; Guarino A; Urbani F; Spagnuolo MI; Pignata C; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.; We describe a human immunodeficiency virus-negative infant with chronic intractable diarrhea due to Cryptosporidium parvum; he had a history of significant weight loss since the second week of life. A preliminary study of his immune function was negative for primary immunodeficiency. To further study his immune functi
Infectious endocarditis due to non-typhi Salmonella in patients infected with human immunodeficiency virus: report of two cases and review.: Clin Infect Dis. 1996 May;22(5):853-5. Unique Identifier : AIDSLINE MED/96309059; Fernandez Guerrero ML; Torres Perea R; Gomez Rodrigo J; Nunez Garcia A; Jusdado JJ; Ramos Rincon JM; Division of Infectious Diseases, Fundacion Jimenez Diaz,; Universidad Autonoma de Madrid, Spain.; Endocarditis is not usually considered a complication of AIDS. Because salmonellal bacteremia is common in HIV-infected patients and because salmonellae have a propensity to adhere to endothelial cells, these patients are at risk of endocarditis and endarteritis. We report two cases of endocarditis due to Salmonella e
Outer retinal necrosis due to a strain of varicella-zoster virus resistant to acyclovir, ganciclovir, and sorivudine.: Clin Infect Dis. 1996 May;22(5):864-5. Unique Identifier : AIDSLINE MED/96309066; Wunderli W; Miner R; Wintsch J; von Gunten S; Hirsch HH; Hirschel B; Division des Maladies Infectieuses, Hopital Cantonal; Universitaire, Geneve, Switzerland.
Age distribution among patients at high risk for human T-cell lymphotrophic virus type I infection.: Clin Infect Dis. 1996 May;22(5):865-6. Unique Identifier : AIDSLINE MED/96309067; Achiron A; Barak Y; Shohat B; Gabbay U; Elizur A; Rotstein Z; Noy S; Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer,; Israel.
Bacille Calmette-Guerin (BCG) meningitis in an AIDS patient 12 years after vaccination with BCG.: Clin Infect Dis. 1996 May;22(5):870-1. Unique Identifier : AIDSLINE MED/96309071; van Deutekom H; Smulders YM; Roozendaal KJ; van Soolingen D; Tuberculosis Department, Onze Lieve Vrouwe Gasthuis, Amsterdam,; The Netherlands.
Pulsatile chest wall swelling due to tubercular mediastinal lymphadenopathy in a patient with human immunodeficiency virus infection and syphilis.: Clin Infect Dis. 1996 May;22(5):871-2. Unique Identifier : AIDSLINE MED/96309072; Sharma SK; Singh YD; Sanchetee PC; Department of Medicine, Armed Forces Medical College, Pune,; India.
Staphylococcal toxic shock syndrome associated with human immunodeficiency virus infection: report of a case with bacteremia.: Clin Infect Dis. 1996 May;22(5):875-6. Unique Identifier : AIDSLINE MED/96309076; Gutierrez Rodero F; Ortiz de la Tabla V; Martinez C; del Mar Masia M; Servicio de Medicina Interna, Hospital de la Marina, Alicante,; Spain.
Vincristine as therapy for idiopathic thrombocytopenic purpura in patients infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1996 May;22(5):880-1. Unique Identifier : AIDSLINE MED/96309080; Ena J; Garcia A; de Mar Masia M
Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with human immunodeficiency virus infection [letter]: Clin Infect Dis. 1996 May;22(5):882-3. Unique Identifier : AIDSLINE MED/96309082; Drexler JA; Matulis WS; David PA; Hernandez JE
Histoplasmosis and blastomycosis.: Clin Infect Dis. 1996 May;22 Suppl 2:S102-11. Unique Identifier : AIDSLINE MED/96302584; Bradsher RW; Division of Infectious Diseases, University of Arkansas for; Medical Sciences, Little Rock 72205, USA.; Histoplasmosis and blastomycosis are caused by dimorphic fungi, can be epidemic or endemic, and can produce a spectrum of illness, from subclinical infection to progressive disseminated disease. Diagnosis of both is best made by visualization of yeast in tissue or by culture. Itraconazole is the drug of choice for tre
The new fungal opportunists are coming.: Clin Infect Dis. 1996 May;22 Suppl 2:S112-8. Unique Identifier : AIDSLINE MED/96302585; Perfect JR; Schell WA; Duke University Medical Center, Durham, North Carolina 27710,; USA.; Frequent and prolonged exposure of immunocompromised patients to a variety of environmental conditions has resulted in the recognition of infections with new fungal opportunists. Infections with fungi such as Fusarium species, Paecilomyces lilacinus, Acremonium species, Trichosporon beigelii, Blastoschizomyces capitat
Recent advances in the management of cryptococcal meningitis in patients with AIDS.: Clin Infect Dis. 1996 May;22 Suppl 2:S119-23. Unique Identifier : AIDSLINE MED/96302586; Powderly WG; Division of Infectious Diseases, Washington University School of; Medicine, St. Louis, Missouri, USA.; The optimum regimen for the treatment of cryptococcal meningitis in patients with AIDS is still not totally clear. The triazoles fluconazole and itraconazole are associated with response rates of 50%-60%. Amphotericin B appears to be associated with a more rapid clearance of organisms, and there are some data suggesti
Is vulvovaginal candidiasis an AIDS-related illness?: Clin Infect Dis. 1996 May;22 Suppl 2:S124-7. Unique Identifier : AIDSLINE MED/96302587; White MH; Infectious Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021, USA.; Early in the AIDS epidemic, retrospective studies reported that vaginal candidiasis occurred more frequently in women who were infected with human immunodeficiency virus (HIV) than in those who were not infected. Some investigators suggested that new onset or recurrent vaginal candidiasis might identify HIV-infected i
Common superficial fungal infections in patients with AIDS.: Clin Infect Dis. 1996 May;22 Suppl 2:S128-32. Unique Identifier : AIDSLINE MED/96302588; Aly R; Berger T; Department of Dermatology, University of California San Francisco; 94143-0517, USA.; Superficial mycotic infections such as seborrheic dermatitis, tinea pedis, tinea corporis, and onychomycosis are common in patients infected with human immunodeficiency virus (HIV). In communities where HIV infections are frequent, some of these clinical presentations serve as markers of the stage of HIV infection. Th
Comparison of the efficacy of amphotericin B and fluconazole in the treatment of cryptococcosis in human immunodeficiency virus-negative patients: retrospective analysis of 83 cases. French Cryptococcosis Study Group.: Clin Infect Dis. 1996 May;22 Suppl 2:S154-60. Unique Identifier : AIDSLINE MED/96302592; Dromer F; Mathoulin S; Dupont B; Brugiere O; Letenneur L; Unite de Mycologie, Institut Pasteur, Paris, France.; We retrospectively analyzed clinical outcome of meningeal and extrameningeal cryptococcosis in HIV-negative patients treated with amphotericin B (43 patients) or fluconazole (40 patients). Amphotericin B and fluconazole were prescribed equally to patients with neoplastic diseases and no risk factor, but organ transpla
Is antifungal susceptibility testing useful in guiding fluconazole therapy?: Clin Infect Dis. 1996 May;22 Suppl 2:S161-5. Unique Identifier : AIDSLINE MED/96302593; Ghannoum MA; Division of Infectious Diseases, St. John's Cardiovascular; Research Center, Torrance, California 90509, USA.; Recently, the National Committee for Clinical Laboratory Standards (NCCLS) subcommittee on antifungal susceptibility testing published a proposed standard for a broth macrodilution method for in vitro susceptibility testing of yeasts. The major reason for developing such a method is to predict the likely clinical and
[The role of the primary care physician in AIDS (editorial)]: Aten Primaria. 1996 Jul-Aug;18(3):103-4. Unique Identifier : AIDSLINE MED/96344532; da Pena Alvarez JM
Rebuttal: time to call a halt to emotions in the assessment of thioacetazone.: Tuber Lung Dis. 1996 Apr;77(2):109-11. Unique Identifier : AIDSLINE MED/96306311; Rieder HL; Enarson DA; International Union Against Tuberculosis and Lung Disease, Paris,; France.
Pott's disease of the cervico-occipital junction in an AIDS patient.: Tuber Lung Dis. 1996 Apr;77(2):188-90. Unique Identifier : AIDSLINE MED/96306325; Ventura G; Cauda R; Paliotta VF; Colosimo C; Lucia MB; Department of Infectious Diseases, Catholic University, Rome,; Italy.; Pott s disease of the cervical spine is relatively rare despite the fact that tuberculous spondylitis is still the most common manifestation of bone and joint infection. We describe a case, the first to our knowledge, of sub-occipital Pott s disease associated with a retropharyngeal abscess in an acquired immune defic
Parkinsonism in an HIV-infected patient with hypodense cerebral lesion.: Tuber Lung Dis. 1996 Apr;77(2):191-2. Unique Identifier : AIDSLINE MED/96306326; de la Fuente-Aguado J; Bordon J; Moreno JA; Sopena B; Rodriguez A; Martinez-Vazquez C; Infectious Diseases Unit, Hospital Xeral of Vigo, Pizarro, Spain.; A 49-year-old man presented with fever and parkinsonism. Examination of cerebrospinal fluid confirmed tuberculous meningitis. Cerebral computerized tomography scan revealed hypodense lesions and human immunodeficiency virus tests were positive. The patient s clinical picture and parkinsonism were improved with tubercu
Tuberculosis without tubercles [editorial; comment]: Tuber Lung Dis. 1996 Jun;77(3):197-8. Unique Identifier : AIDSLINE MED/96318614; Horsburgh CR Jr
Tuberculosis in Siberia: 1. An epidemiological and microbiological assessment.: Tuber Lung Dis. 1996 Jun;77(3):199-206. Unique Identifier : AIDSLINE MED/96318615; Drobniewski F; Tayler E; Ignatenko N; Paul J; Connolly M; Nye P; Lyagoshina T; Besse C; Regional Tuberculosis Centre, Dulwich Public Health Laboratory,; London.; SETTING: Siberia, Russian Federation. OBJECTIVE: To assess the situation regarding tuberculosis as a paradigm for the Russian Federation. DESIGN: Data was obtained from official sources and through visits to dispensaries and hospitals in 1994. RESULTS: The downward trend in notifications of tuberculosis throughout Rus
Tuberculosis in sub-Saharan Africa: a regional assessment of the impact of the human immunodeficiency virus and National Tuberculosis Control Program quality.: Tuber Lung Dis. 1996 Jun;77(3):220-5. Unique Identifier : AIDSLINE MED/96318618; Cantwell MF; Binkin NJ; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, GA, USA.; BACKGROUND: The effect of the human immunodeficiency virus (HIV) epidemic on tuberculosis (TB) has been evaluated for certain countries in sub-Saharan Africa. However, no multi-country comparisons have been performed of the magnitude of the changes in TB case rates and the roles of the HIV epidemic and national TB con
Pulmonary tuberculosis in Guinea-Bissau: clinical and bacteriological findings, human immunodeficiency virus status and short term survival of hospitalized patients.: Tuber Lung Dis. 1996 Jun;77(3):226-32. Unique Identifier : AIDSLINE MED/96318619; Naucler A; Winqvist N; Dias F; Koivula T; Lacerda L; Svenson SB; Biberfeld G; Norberg R; Kallenius G; Swedish Institute for Infectious Disease Control, Stockholm.; OBJECTIVE: To study tuberculosis patients in Guinea-Bissau with regard to clinical findings, bacteriologically verified diagnosis, human immunodeficiency virus (HIV) status and short term survival. DESIGN: 763 consecutive patients referred to the tuberculosis clinic with pulmonary
Pattern of utilization of rifabutin for prophylaxis of Mycobacterium avium complex among patients with advanced human immunodeficiency virus disease in a community setting.: Tuber Lung Dis. 1996 Jun;77(3):233-8. Unique Identifier : AIDSLINE MED/96318620; Mandigo K; Hogg RS; Phillips P; Barber C; Le T; Bessuille E; Black W; O'Shaughnessy MV; Schechter MT; Montaner JS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital.; OBJECTIVE: To characterize the pattern of utilization, effectiveness, and safety profile of rifabutin for Mycobacterium avium complex (MAC) prophylaxis among individuals with advanced human immunodeficiency virus disease in a community setting. METHODS: Individuals who, while registered in the provincial drug distribu
Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients.: Tuber Lung Dis. 1996 Jun;77(3):244-9. Unique Identifier : AIDSLINE MED/96318622; Di Perri G; Cazzadori A; Vento S; Bonora S; Malena M; Bontempini L; Lanzafame M; Allegranzi B; Concia E; Institute of Immunology and Infectious Diseases, University of; Verona, Italy.; SETTING: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of
Use of DNA restriction fragment typing in the differentiation of Mycobacterium tuberculosis complex isolates from animals and humans in Burundi.: Tuber Lung Dis. 1996 Jun;77(3):264-8. Unique Identifier : AIDSLINE MED/96318625; Rigouts L; Maregeya B; Traore H; Collart JP; Fissette K; Portaels F; Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.; SETTING: Bubanza Hospital and Veterinary Laboratory in Bujumbura, Burundi . OBJECTIVE: To monitor the rate of Mycobacterium bovis infections among tuberculosis (TB) patients and among slaughtered cattle, and to analyse the polymorphism among deoxyribonucleic acid (DNA) fingerprints
Polymerase chain reaction for non-invasive diagnosis of brain mass lesions caused by Mycobacterium tuberculosis: report of five cases in human immunodeficiency virus-positive subjects.: Tuber Lung Dis. 1996 Jun;77(3):280-4. Unique Identifier : AIDSLINE MED/96318628; Monno L; Angarano G; Romanelli C; Giannelli A; Appice A; Carbonara S; Costa D; Pastore G; Clinic of Infectious Diseases, University of Bari, Italy.; To investigate whether the polymerase chain reaction (PCR) on the IS6110 sequence of Mycobacterium tuberculosis could permit the early and non-invasive diagnosis of tuberculous brain lesions without meningeal involvement in acquired immunodeficiency virus patients, we examined retrospective cerebrospinal fluid (CSF) s
Serological diagnosis of tuberculosis employing lipooligosaccharide antigen in developing countries [letter]: Tuber Lung Dis. 1996 Jun;77(3):291. Unique Identifier : AIDSLINE MED/96318631; Arya SC
The application of empiric antituberculosis treatment [letter]: Tuber Lung Dis. 1996 Jun;77(3):292. Unique Identifier : AIDSLINE MED/96318633; Lawn SD; Tumasi PA
Tuberculosis among European patients with the acquired immune deficiency syndrome. The AIDS in Europe Study Group.: Tuber Lung Dis. 1996 Aug;77(4):322-8. Unique Identifier : AIDSLINE MED/96388847; Sudre P; Hirschel BJ; Gatell JM; Schwander S; Vella S; Katlama C; Ledergerber B; d'Arminio Monforte A; Goebel FD; Pehrson PO; Pedersen C; Lundgren JD; Division de Maladies Infectieuses, Hopital Cantonal; Universitaire, Geneve, Switzerland. SUDRE@DMINOV1.HCUGE.CH; OBJECTIVES: To describe the characteristics of acquired immune deficiency syndrome (AIDS) patients with tuberculosis in Europe; to assess the incidence and risk factors of tuberculosis after AIDS; to compare survival of AIDS patients with and without extra-pulmonary tuberculosis (EPTB) at the time of AIDS diagnosis. D
Spinal tuberculosis in patients with human immunodeficiency virus infection: clinical presentation, therapy and outcome.: Tuber Lung Dis. 1996 Aug;77(4):329-34. Unique Identifier : AIDSLINE MED/96388848; Leibert E; Schluger NW; Bonk S; Rom WN; Division of Pulmonary and Critical Care Medicine, New York; University Medical Center, NY, USA.; SETTING: Bellevue Hospital, a large public hospital in New York City. OBJECTIVE: To discern the clinical characteristics of spinal tuberculosis (Pott s disease) in patients with the human immunodeficiency virus (HIV). DESIGN: Review of all cases of spinal tuberculosis seen at the hospital from 1988 to 1995, with compa
Filgrastim (r-metHuG-CSF): the first 10 years.: Blood. 1996 Sep 15;88(6):1907-29. Unique Identifier : AIDSLINE MED/96420209; Welte K; Gabrilove J; Bronchud MH; Platzer E; Morstyn G; Medizinische Hochschule, Hannover, Germany.
The T-cell receptor repertoires expressed by CD4+ and CD4- large granular lymphocytes derived from the same patients suggest the persistent action of an immune-mediated selection process.: Blood. 1996 Sep 15;88(6):2133-43. Unique Identifier : AIDSLINE MED/96420234; Quiros-Roldan E; Sottini A; Gulletta M; Stellini R; Puoti M; Primi D; Imberti L; Terzo Laboratorio Analisi, Spedali Civili, Brescia, Italy.; The lymphoproliferative syndrome with large granular lymphocytes (LGL) is an heterogeneous disorder of unknown etiology. The analysis of T-cell receptor (TCR) genes rearrangements has shown that, in most cases, the disease is associated with clonal proliferation of CD8+CD57+ LGL. However, the putative neoplastic natur
Evidence for an in vivo superantigenic activity in human immunodeficiency virus-infected individuals.: Blood. 1996 Sep 15;88(6):2151-61. Unique Identifier : AIDSLINE MED/96420236; Garcia S; Dadaglio G; Cilote V; Chenal H; Bondurand A; Gougeon ML; Department SIDA et Retrovirus, Institut Pasteur, Paris, France.; In a previous study, we reported the existence of a specific anergy affecting selectively the V beta 8 subset in both CD4 and CD8 T cells from human immunodeficiency virus (HIV)-infected persons. Because this observation gives evidence for a previous in vivo activation of this subset by a superantigen, we further char
Surgical and psychological stressors differentially affect cytolytic responses in the rhesus monkey.: Brain Behav Immun. 1996 Mar;10(1):27-43. Unique Identifier : AIDSLINE MED/96328570; Lemieux AM; Coe CL; Ershler WB; Karaszewski JW; Department of Psychology, University of Wisconsin, Madison 53706,; USA.; Four experiments were conducted in aged rhesus monkeys to investigate how physical and psychological stressors influence the lymphocyte cytolytic responses against two target cell lines. An initial analysis of the lytic activity of various cell subsets against K562 and RAJI target cell lines suggested that both CD3+CD
Recent advances: antiinfectives.: Ann Pharmacother. 1995 Oct;29(10):1035-40. Unique Identifier : AIDSLINE MED/96113215; Briceland LL; Cleary JD; Fletcher CV; Healy DP; Peloquin CA; Albany College of Pharmacy, NY, USA.; OBJECTIVE: To update readers on the significant changes in infectious diseases pharmacotherapy. DATA SOURCES: An Index Medicus and Iowa Drug Information Service search (1993-1994) of English-language literature pertaining to the selected topic areas was performed. Additional information from abstracts presented at sci
Treatment of non-HIV cryptosporidial diarrhea with azithromycin.: Ann Pharmacother. 1995 Oct;29(10):991-3. Unique Identifier : AIDSLINE MED/96113206; Bessette RE; Amsden GW; Division of Infectious Diseases, Saint Vincent Hospital,; Worcester, MA 01604, USA.; OBJECTIVE: To report a patient with non-HIV-related cryptosporidial diarrhea who was treated effectively with a regimen of high-dose azithromycin therapy. CASE SUMMARY: A 42-year-old immunocompetent man contracted cryptosporidiosis from an ailing calf that he had purchased. He finally was admitted to the hospital beca
Gabapentin adjunctive therapy in neuropathic pain states.: Clin J Pain. 1996 Mar;12(1):56-8. Unique Identifier : AIDSLINE MED/96302605; Rosner H; Rubin L; Kestenbaum A; Department of Anesthesiology, New York Hospital, Cornell Medical; Center, New York 10021, USA.; OBJECTIVE: This is a report of a trial of the new antiepileptic agent gabapentin in patients with intractable neuropathic pain. DESIGN: A case series of patients with a diagnosis of neuropathic pain whose previous management was inadequate were given oral gabapentin in increasing doses and were followed for a minimum
Tuberculosis in the elderly. Epidemiology and optimal management.: Drugs Aging. 1996 Jun;8(6):436-44. Unique Identifier : AIDSLINE MED/96338548; Davies PD; Tuberculosis Research Unit, Cardiothoracic Centre, Liverpool,; England.; The problem with the emergence of HIV-associated tuberculosis (which usually occurs in young adults) is that attention has been diverted away from the fact that, in the developed world, the elderly represent the biggest pool of tubercular disease and therefore the greatest pool of infection within the community. Altho
Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene.: Mamm Genome. 1996 May;7(5):353-5. Unique Identifier : AIDSLINE GENBANK/U27177; Huppi K; Siwarski D; Mock BA; Dosik J; Hamel PA; Laboratory of Genetics, Molecular Genetics Section, Building 37,; Room 2B-21, National Cancer Institute, National Institutes of; Health, Bethesda, Maryland 20892, USA.; Progression through the G1 phase of the cell cycle is regulated, in part, by the pRB-family proteins, pRB and p107. The basis for this regulation is due to a network of interactions between the pRB-family proteins, pRB, p107, and p130; the E2F-family of transcription factors; and cyclins D, E, and A. One of the pRB-fa
Ascorbate effect on cytokine stimulation of HIV production.: Nutrition. 1995 Sep-Oct;11(5 Suppl):684-7. Unique Identifier : AIDSLINE MED/96356148; Harakeh S; Jariwalla RJ; Virology and Immunodeficiency Research Program, Linus Pauling; Institute of Science and Medicine, Palo Alto, California 94306,; USA.; We have recently shown that ascorbic acid (AA) suppresses the production of HIV in a latently infected T-lymphocytic cell line (ACH-2) following stimulation with the tumor promoter, PMA. To evaluate the effect of ascorbic acid on virus activation following treatment with inflammatory cytokine, we tested tumor necrosis
T-cell development in early partially decapitated chicken embryos.: Dev Immunol. 1995;4(3):211-26. Unique Identifier : AIDSLINE MED/96366383; Moreno J; Vicente A; Varas A; Zapata AG; Centro Nacional de Microbiologia, Virologia e Immunologia; Sanitaries Instituto de Salud Carlos III, Madrid, Spain.; We have evaluated the immunohistological and cytofluorometric changes that occur in the thymus of chicken embryos partially decapitated at 33-38 hr of incubation (DCx embryos) in an attempt to analyze possible neuroendocrinological influences on T-cell differentiation and, indirectly, the ontogeny of the so-called neu
Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors.: Gene Expr. 1996;5(4-5):217-28. Unique Identifier : AIDSLINE MED/96303659; Gatignol A; Duarte M; Daviet L; Chang YN; Jeang KT; Unite 332 INSERM, Institut Cochin de Genetique Moleculaire,; Paris, France.; The regulation of HIV expression is controlled by the activity of the Long Terminal Repeat (LTR). Trans-activation by the virally encoded Tat protein is one of the main mechanisms of LTR activation. Tat binds to its target, TAR RNA, and cellular proteins that bind the LTR, Tat, or TAR RNA are important components of t
From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV.: Gene Expr. 1996;5(4-5):229-43. Unique Identifier : AIDSLINE MED/96303660; Thiesen HJ; Institut fur Immunologie, Rostock, Germany.; Tissue-specific gene regulation of eukaryotic organisms is to a large extent mediated by transcription factors that interact with genomic DNA sequences in a sequence-specific manner. The purpose of this synopsis is to put forward the potential of designer zinc finger proteins in treating infections of human immunodefi
The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.: Gene Expr. 1996;5(4-5):245-53. Unique Identifier : AIDSLINE MED/96303661; Van Lint C; Emiliani S; Verdin E; Laboratory of Molecular Virology, Picower Institute for Medical; Research, Manhasset, NY 11030, USA.; Posttranslational modifications of histones in chromatin are emerging as an important mechanism in the regulation of gene expression. Changes in histone acetylation levels occur during many nuclear processes such as replication, transcriptional silencing, and activation. Histone acetylation levels represent the result
Increased prevalence of septal cavitation in a nonschizophrenic sample: an MRI study of HIV-infected individuals.: J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):47-53. Unique Identifier : AIDSLINE MED/96403154; Lalonde FM; Martin A; Myslobodsky MS; Laboratory of Clinical Science, National Institute of Mental; Health, Bethesda, Maryland 20892, USA. francois@codon.nih.gov; Analyses of MRI scans of 26 asymptomatic HIV-infected individuals (HIV+) and 10 HIV-seronegative psychiatric control subjects (HIV-) revealed an incidental finding: 50% of the HIV+ subjects had discernible cleft in the septum pellucidum (cavum septi pellucidi; CSP), compared to only 20% of the HIV- control subjects. H
Neuropsychological effects of Interferon Alfa-n3 treatment in asymptomatic human immunodeficiency virus-1-infected individuals.: J Neuropsychiatry Clin Neurosci. 1996 Winter;8(1):74-81. Unique Identifier : AIDSLINE MED/96403158; Mapou RL; Law WA; Wagner K; Malone JL; Skillman DR; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland 20850. rmapou@hiv.hjf.org; Eighteen asymptomatic HIV-1-infected (HIV+) individuals were evaluated neuropsychologically before and during Interferon Alfa-n3 treatment. All 18 were evaluated twice, and 9 were evaluated three times. Analyses revealed few significant effects of treatment on cognitive, motor, and affective function. Improvements occ
1996 human immunodeficiency virus update for the primary care provider.: Nurse Pract Forum. 1996 Mar;7(1):16-22. Unique Identifier : AIDSLINE MED/96380646; Newmann RE; Nishimoto PW; Tripler Army Medical Center, Hawaii 96859-5000, USA.; Rapid development and changes in the care of patients with human immunodeficiency virus (HIV) infection will continue, bringing challenge to the nurse in advanced practice (APN) to keep up with those developments. The demand for APNs to provide primary care to many of these patients will be high. By creating working r
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. HIV Italian Seroconversion Study Group.: BMJ. 1996 Sep 7;313(7057):583-6. Unique Identifier : AIDSLINE MED/96399870; Pezzotti P; Phillips AN; Dorrucci M; Lepri AC; Galai N; Vlahov D; Rezza G; Centre Operative AIDS, Istituto Superiore di Sanita, Rome,; Italy.; OBJECTIVES: To determine whether rate of development of AIDS is affected by category of exposure to HIV and whether the more rapid development found in older subjects persists for each exposure category. DESIGN: Longitudinal study of people with known date of seroconversion to HIV. SETTING: 16 HIV treatment centres th
Will we ever know when to treat HIV infection?: BMJ. 1996 Sep 7;313(7057):608-10. Unique Identifier : AIDSLINE MED/96399879; Phillips AN; Smith GD; Johnson MA; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London.; Confidence in the efficacy of using antiretroviral drugs to treat HIV infection has grown in the past year as a result of the prolonged survival of those randomly allocated to receive an additional drug in comparative controlled trials. HIV remains, however, the only serious infectious disease for which antimicrobial
Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism.: Protein Sci. 1996 Apr;5(4):786-8. Unique Identifier : AIDSLINE MED/96259239; Redinbo MR; Eide SM; Stone RL; Dixon JE; Yeates TO; Department of Chemistry and Biochemistry, University of; California, Los Angeles 90095, USA.; Adenylosuccinate lyase (ASL) from Bacillus subtilis has been crystallized and structural analysis by X-ray diffraction is in progress. ASL is a 200-kDa homotetramer that catalyzes two distinct steps of de novo purine biosynthesis leading to the formation of AMP and IMP; both steps involve the beta-elimination of fumar
Viral RNA binding properties of human immunodeficiency virus type-2 (HIV-2) nucleocapsid protein-derived synthetic peptides.: Biochem Mol Biol Int. 1996 May;38(6):1143-54. Unique Identifier : AIDSLINE MED/96336358; Komatsu H; Tsukahara T; Tozawa H; Department of Immunology, School of Allied Health Sciences,; Kitasato University, Kanagawa, Japan.; The nucleocapsid (NC) protein of HIV-2 (NCp8) contains two Cys-His arrays which function as zinc finger motifs (ZFMs). In this study, we analyzed the viral RNA-binding properties of NCp8-derived synthetic peptides using ultraviolet (UV) cross-linking assay. Several synthetic peptides containing ZFM(s) interacted pH-de
[Study of hemoglobinopathies found in Belgium]: Bull Mem Acad R Med Belg. 1995;150(10-11):367-75; discussion 376-8. Unique Identifier : AIDSLINE MED/96404603; Fondu P; Our purpose is to illustrate our contributions to the study of the haemoglobinopathies observed in Belgium . We described a new deletion leading to major thalassaemia and have established that the erythropoietin production is adequate in this disease. We were particularly intereste
[Progress in vaccination against AIDS]: Bull Mem Acad R Med Belg. 1995;150(3-4):145-53; discussion 153-5. Unique Identifier : AIDSLINE MED/96111726; Burny A; UER Biologie moleculaire et Physiologie animale de la faculte; des Sciences agronomiques de Gembloux.; Two vaccination trials against AIDS viruses are reported. The first trial was a prophylactic vaccination carried out in the pig-tailed macaque (Macacca nemestrina) against simian immunodeficiency virus (SIV) variant PBj14. The immunogen was a Semliki forest virus (SFV) recombinant expressing SFV - PBj14 envelope prote
Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases [see comments]: Nat Genet. 1996 Sep;14(1):42-9. Unique Identifier : AIDSLINE GENBANK/Z69795; Reifsnyder C; Lowell J; Clarke A; Pillus L; Department of Molecular, Cellular and Developmental Biology,; University of Colorado, Boulder 80309, USA.; Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe ho
Management of ulcerated AIDS-related Kaposi's sarcoma lesions.: J Wound Ostomy Continence Nurs. 1996 Mar;23(2):115-8. Unique Identifier : AIDSLINE MED/96403329; Gordon R; Grant L
[Outcome of the HIV/AIDS pandemic in Africa and in Asia]: Arch Pediatr. 1996;3 Suppl 1:13s-16s. Unique Identifier : AIDSLINE MED/96388559; Lepage P; Service de pediatrie, centre interuniversitaire Ambroise-Pare; Mons, Belgique.
[HIV transmission from mother to child: risk factors, period, prevention. Groupe Francais d'etudes de l'infection VIH du nouveau-ne]: Arch Pediatr. 1996;3 Suppl 1:17s-19s. Unique Identifier : AIDSLINE MED/96388560; Mayaux MJ; Inserm unite 292, hopital de Bicetre, Le Kremlin-Bicetre; France.
[Natural history of HIV infection in children]: Arch Pediatr. 1996;3 Suppl 1:20s-23s. Unique Identifier : AIDSLINE MED/96388561; Blanche S; Department de pediatrie, hopital Necker-Enfants-Malades,; Paris, France.
[Diagnosis of HIV infection in newborn infants in Europe and in developing countries]: Arch Pediatr. 1996;3 Suppl 1:24s-26s. Unique Identifier : AIDSLINE MED/96388562; Rouzioux C; Burgard M; Chaix ML; Laboratoire de virologie, hopital Necker-Enfants-Malades, Paris,; France.
[Management of children infected by human immunodeficiency virus and of the family in the frame work of humanitarian mission in Tanzania]: Arch Pediatr. 1996;3 Suppl 1:27s-31s. Unique Identifier : AIDSLINE MED/96388563; Faye A; Service d'hematologie-immunologie, hopital Robert-Debre,; Paris, France.
[Non-infectious neurological involvement in HIV-1 infection in children (letter)]: Arch Pediatr. 1996;3 Suppl 1:360s-361s. Unique Identifier : AIDSLINE MED/96388683; Tardieu M
Primary brain tumors in the acquired immunodeficiency syndrome.: Curr Opin Neurol. 1995 Dec;8(6):419-23. Unique Identifier : AIDSLINE MED/96275325; DeAngelis LM; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, New York, USA.; Primary central nervous system lymphoma occurs in about 10% of patients with the acquired immunodeficiency syndrome, and is the most common brain tumor in this population. Patients present with an altered mental status and lateralizing signs. Computed tomography or magnetic resonance scan usually demonstrates single o
Rural human immunodeficiency virus health service provision. Indications of rural-urban travel for care.: Arch Fam Med. 1996 Sep;5(9):469-73. Unique Identifier : AIDSLINE MED/96390566; Mainous AG 3rd; Matheny SC; Department of Family Practice, University of Kentucky, Lexington,; USA.; We studied the travel of rural individuals positive for human immunodeficiency virus (HIV) to urban areas for HIV diagnosis and for ambulatory and inpatient HIV-related health services. We surveyed all (N = 84) identified HIV-positive adults (aged 18 years or older) residing in rural central and eastern Kentucky. Sixt
The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.: Eur J Neurosci. 1995 Dec 1;7(12):2502-7. Unique Identifier : AIDSLINE MED/96256108; Dreyer EB; Lipton SA; Department of Ophthalmology, Harvard Medical School, Boston, MA; 02115, USA.; The human immunodeficiency virus coat protein gp120 injures central mammalian neurons both in vitro and in vivo, and this observation may contribute, at least in part, to the neurological dysfunction associated with the acquired immunodeficiency syndrome. Recent work suggests that gp120 mediates neuronal damage predom
In vivo magnetic resonance spectroscopy in HIV and HIV-related brain diseases.: Rev Neurosci. 1995 Oct-Dec;6(4):365-78. Unique Identifier : AIDSLINE MED/96402424; Chang L; Department of Neurology, UCLA School of Medicine, Torrance, CA,; USA.; Central nervous system involvement is common in the later stages of HIV infection. The pathophysiology for the development of cognitive impairment in HIV infection is still unclear. Magnetic resonance imaging shows brain atrophy and non-specific white matter abnormalities in some of the patients with HIV
Specific and rapid detection of Microsporidia in stool specimens from AIDS patients by PCR.: Parasite. 1996 Mar;3(1):85-6. Unique Identifier : AIDSLINE MED/96307438; Ombrouck C; Ciceron L; Desportes-Livage I; Unite INSERM 313, CHU Pitie-Salpetriere, Paris.; Two microsporidian species, Enterocytozoon bieneusi and Encephalitozoon intestinalis, are the cause of diarrhoea and wasting syndrome in AIDS patients. A new PCR assay is proposed for the rapid and specific detection of these parasites in stools.
Morphine stimulates phagocytosis of Mycobacterium tuberculosis by human microglial cells: involvement of a G protein-coupled opiate receptor.: Adv Neuroimmunol. 1995;5(3):299-309. Unique Identifier : AIDSLINE MED/96356206; Peterson PK; Gekker G; Hu S; Sheng WS; Molitor TW; Chao CC; Neuroimmunobiology and Host Defense Laboratory, Minneapolis; Medical Research Foundation, MN 55404, USA.; Opiate-induced immunosuppression has been implicated in the pathogenesis of infections caused by a variety of microorganisms, including human immunodeficiency virus (HIV). Although effects of opiates on lymphocyte function have been studied more extensively, morphine also has been shown to inhibit several functional a
Interactions of human immunodeficiency virus type 1 transactivator of transcription protein with signal transduction pathways.: Adv Neuroimmunol. 1995;5(3):321-5. Unique Identifier : AIDSLINE MED/96356208; Garza HH Jr; Carr DJ; Department of Microbiology Immunology, LSU Medical Center, New; Orleans 70112-1393, USA.; The current state of knowledge investigating Tat interactions with signal transduction pathways is still in its infancy but has made significant progress toward understanding HIV pathology. This area is of great interest because Tat is among a small group of newly discovered RNA-based regulators of transcription. What
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases.: Adv Neuroimmunol. 1995;5(3):335-58. Unique Identifier : AIDSLINE MED/96356210; Yoshioka M; Bradley WG; Shapshak P; Nagano I; Stewart RV; Xin KQ; Srivastava AK; Nakamura S; Department of Neurology, Tohoku University School of Medicine,; Sendai, Japan.; Central nervous system (CNS) involvement is common during human immunodeficiency virus type-1 (HIV-1) infection. The neurologic disease of the CNS most frequently observed during acquired immunodeficiency syndrome (AIDS) is HIV-1-associated cognitive/motor complex or AIDS dementia
Neuropathies in HIV infection.: Baillieres Clin Neurol. 1996 Mar;5(1):199-218. Unique Identifier : AIDSLINE MED/96304732; Dalakas MC; Cupler EJ; National Institute of Neurological Disorders and Stroke, National; Institute of Health, Bethesda, MD 20892, USA.; Peripheral neuropathies represent the most common neurological manifestation in patients infected with HIV infection occurring either early in the infection or during the course of the illness. They present as acute or chronic demyelinating neuropathies (Guillain-Barre syndrome or chronic inflammatory demyelinating po
Immune neuropathies in childhood.: Baillieres Clin Neurol. 1996 Mar;5(1):233-44. Unique Identifier : AIDSLINE MED/96304734; Sladky JT; Emory University School of Medicine, Atlanta, GA 30322, USA.; In contradistinction to older populations, immune-mediated disorders (principally demyelinating processes) account for nearly half of peripheral neuropathies in childhood. The largest single diagnostic entity is GBS, which makes up approximately 25% of sensorimotor neuropathies in patients under 18 years of age. The c
Pulmonary immune response to Mycobacterium tuberculosis and human immunodeficiency virus.: Infect Agents Dis. 1996 Mar;5(2):108-18. Unique Identifier : AIDSLINE MED/96297131; Rich EA; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio, USA.
Immunosuppression in tuberculosis.: Infect Agents Dis. 1996 Mar;5(2):62-72. Unique Identifier : AIDSLINE MED/96297127; Ellner JJ; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, Ohio, USA.
The role of T-cell subsets in Mycobacterium tuberculosis infection.: Infect Agents Dis. 1996 Mar;5(2):73-81. Unique Identifier : AIDSLINE MED/96297128; Boom WH; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, Ohio, USA.; During the last 10 years, studies of the immune response to M. tuberculosis in humans and animal models have increased our understanding of the complex roles of T-cell subsets in protection against tuberculosis. Although CD4+ T cells remain the dominant and critical T-cell subset, others, such as gamma delta and CD8+
Regulation of the human immune response in tuberculosis.: Infect Agents Dis. 1996 Mar;5(2):82-97. Unique Identifier : AIDSLINE MED/96297129; Tsuyuguchi I; Osaka Prefectural Habikino Hospital, Japan.
Cytokine circuits in tuberculosis.: Infect Agents Dis. 1996 Mar;5(2):98-107. Unique Identifier : AIDSLINE MED/96297130; Toossi Z; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, Ohio, USA.
Running the gamut of retroviral variation.: Trends Microbiol. 1996 Apr;4(4):135-41. Unique Identifier : AIDSLINE MED/96290823; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France. simon@pasteur.fr; The retroviral DNA polymerase, or reverse transcriptase, lacks a 3 exonuclease proofreading activity. This causes a high mutation rate with the result that genetic diversity and drug resistance are increased. Only combination chemotherapy has the potential to out-manoeuvre these viruses. However, there is no evidence
AZT modulation of trimetrexate myelotoxicity: evidence from an HL60 model.: Res Commun Mol Pathol Pharmacol. 1995 Dec;90(3):403-12. Unique Identifier : AIDSLINE MED/96342537; Nusbaum NJ; Abraham T; DWH Hematology/Oncology Complex Brookdale Hospital Medical; Center, Brooklyn, N.Y. 11212 USA.; AZT is widely used in combination with other potentially myelotoxic drugs. Bone marrow suppression may limit the vigor of therapy directed at HIV itself, opportunistic infections, and/or AIDS-associated malignancies. Evidence from an HL60 model sugges
Functional consequences of macrophage infection by human immunodeficiency virus: bispecific antibody targeting of HIV-1-infected cells to Fc gamma RI expressing effector cells.: J Hematother. 1995 Dec;4(6):579-85. Unique Identifier : AIDSLINE MED/96402925; Mabondzo A; Le Naour R; Le Grand R; Vaslin B; Benveniste O; Cheret A; Raoul H; Romet-Lemonne JL; Dormont D; Service de Neurovirologie, CEA, CRSSA/DSV/DRM/IPSC,; Fontenay-aux-Roses, France.; Human monocytes/macrophages play a major role in pathogenesis of human immunodeficiency virus (HIV) infection. These cells have been suspected of acting as a reservoir for the virus and are important in viral dissemination and persistence in infected individual. Furthermore, several biologic and clinical features indi
The use of antibody fragments for crystallization and structure determinations.: Structure. 1995 Dec 15;3(12):1291-3. Unique Identifier : AIDSLINE MED/96363666; Kovari LC; Momany C; Rossmann MG; Department of Biological Sciences, Purdue University, West; Lafayette, IN 47907-1392, USA.
X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.: Structure. 1995 Dec 15;3(12):1307-14. Unique Identifier : AIDSLINE MED/96363668; Morera S; Lacombe ML; Xu Y; LeBras G; Janin J; Laboratoire de Biologie Structurale, UMR 9920 CNRS-Universite; Paris-Sud, Gif-sur-Yvette, France.; BACKGROUND: Nucleoside diphosphate (NDP) kinases provide precursors for DNA and RNA synthesis. In mammals, these enzymes are also involved in cell regulations. Human NDP kinase B, product of the human nm23-H2 gene, is both an enzyme and a transcription factor. It activates transcription of the c-myc oncogene independe
A randomized controlled study of the effect of bedside leucocyte depletion on the immunosuppressive effect of whole blood transfusion in patients undergoing elective colorectal surgery.: Br J Surg. 1996 Jul;83(7):973-7. Unique Identifier : AIDSLINE MED/96408805; Jensen LS; Hokland M; Nielsen HJ; Department of Surgical Gastroenterology L, Aarhus University; Hospital, Denmark.; In a randomized study the effect of whole blood transfusion versus bedside leucocyte-depleted blood transfusion on lymphocyte proliferation, CD4+:CD8+ ratio, and levels of soluble interleukin 2 receptor (sIL-2R) and interleukin (IL) 6, as well as on the development of postoperative wound infection and intra-abdominal
HIV lymphadenopathy--a histopathological and immunomorphological study of 65 cases.: Pol J Pathol. 1995;46(4):211-7. Unique Identifier : AIDSLINE MED/96287960; Walewska-Zielecka B; Nowoslawski A; Department of Immunopathology, National Institute of Hygiene,; Warszawa.; Lymph nodes from 65 HIV-infected persons were studied by morphological and immunomorphological methods. Early stages of HIV lymphadenopathy (follicular hyperplasia without fragmentation or follicular hyperplasia with severe fragmentation) were revealed in 92% of patients with PGL and the most advanced stadium of HIV-r
Elevated concentrations of circulating intercellular adhesion molecule 1 (ICAM-1) and of vascular cell adhesion molecule 1 (VCAM-1) in HIV-1 infection.: Cell Adhes Commun. 1995 Aug;3(3):179-85. Unique Identifier : AIDSLINE MED/96114076; Gattegno L; Bentata-Peyssare M; Gronowski S; Chaouche K; Ferriere F; Laboratory of the Cellular Biology, Hopital Avicenne, Bobigny,; France.; The aim of this study was to determine whether elevated levels of circulating forms of the soluble adhesion molecules, Intercellular Adhesion Molecule-1 (cICAM-1), Vascular Cell Adhesion Molecule-1 (cVCAM-1) and E-Selectin (cE-Selectin) are observed in the sera of HIV-1 infected individuals as compared to healthy HIV
Drugs of abuse and renal disease.: Curr Opin Nephrol Hypertens. 1996 Mar;5(2):122-6. Unique Identifier : AIDSLINE MED/96303199; Bakir AA; Dunea G; Cook County Hospital, Division of Nephrology, Chicago, IL 60612,; USA.; The complications of drug abuse encompass a spectrum of glomerular, interstitial, and vascular diseases. They comprise the heroin-associated nephropathy seen in African-American intravenous drug addicts, which, however, has given way in the 1990s to HIV-associated nephropathy. Infections with methicillin-resistant Sta
Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease.: QJM. 1996 Mar;89(3):177-85. Unique Identifier : AIDSLINE MED/96297817; McNeil AJ; Yap PL; Gore SM; Brettle RP; McColl M; Wyld R; Davidson S; Weightman R; Richardson AM; Robertson JR; Department of Applied Mathematics, University of Zurich,; Switzerland.; We examined how HLA types A1-B8-DR3 and B27 were related to progression of clinical disease and rate of loss of CD4 lymphocytes in the Edinburgh City Hospital cohort of HIV-positive patients, mainly injection drug users. Patients (n = 692) were prospectively followed from 1985 through March 1994. Accurately estimated
Effect of antiviral treatments on the bone marrow in murine aids.: Blood Cells Mol Dis. 1995;21(2):109-18. Unique Identifier : AIDSLINE MED/96113692; Brandi G; Carnevali A; Rossi L; Fraternale A; Schiavano GF; Magnani M; Istituto di Igiene, Universita degli Studi di Urbino, Italy.; Blood cytopenia is a common feature in HIV infection, occurring in up to 70% of patients with AIDS. Since at present it is not clear to what extent this is intrinsic to HIV infection or due to opportunistic infections and antiretroviral agents we have investigated the long-term effects of conventional and new antivira
Adenosine deaminase (ADA) activity in tissues and sera from normal and leukaemic cattle.: Br Vet J. 1996 Jul;152(4):485-8. Unique Identifier : AIDSLINE MED/96383935; Yasuda J; Tanabe T; Hashimoto A; Too K; Veterinary Teaching Hospital, Faculty of Veterinary Medicine,; Hokkaido University, Sapporo, Japan.
Concurrent Epstein-Barr virus associated non-Hodgkin lymphoma and recurrent Hodgkin disease.: J Pediatr Hematol Oncol. 1996 May;18(2):182-6. Unique Identifier : AIDSLINE MED/96209747; Gross TG; Hilden JM; Manivel JC; Ransay NKC; MacMahon EME; Department of Pathology, University of Nebraska Medical Center,; Omaha 68198-5660, USA.; PURPOSE: Patients treated for Hodgkin disease (HD) are at increased risk for developing secondary neoplasms, including non-Hodgkin lymphoma (NHL). We present a patient who developed NHL (brain and lungs) as a second malignancy together with recurrent HD (bone marrow). Because HD and NHL have both been associated with
Fatal Mycobacterium avium complex disease in a patient with acute nonlymphoblastic leukemia.: J Pediatr Hematol Oncol. 1996 May;18(2):218-22. Unique Identifier : AIDSLINE MED/96209756; Martinez-Arroyo L; Ramos Amador JT; Cela de Julian E; Ruiz Contreras J; Torres Valdivieso MJ; Lopez Perez J; Division of Pediatric Intensive Care, Hospital Materno-Infantil,; Madrid, Spain.; PURPOSE: The objective of this article was to present the diagnosis of a fatal infection by Mycobacterium avium complex (MAC) in a child with acute myelogenous leukemia, a disease rarely reported in non-HIV infected children. METHODS: Specific identification of MAC was made by culture in BACTEC system from an open lun
The management of HIV-positive pregnant women.: Mod Midwife. 1996 Apr;6(4):26-8. Unique Identifier : AIDSLINE MED/96380892; Lewis P; Smith R; Midwifery and Women's Health, University of Bournemouth.; The chance of a baby born to an HIV-positive mother being HIV positive itself is 1 in 6. HIV infection cannot be diagnosed in utero. A diagnosis of HIV infection may not be excluded until the baby is 15 months old. There is no sound evidence that pregnancy worsens maternal HIV disease. The options of caesarean section
The role of Candida albicans secreted aspartic proteinase in the development of candidoses.: J Mol Med. 1996 Mar;74(3):135-42. Unique Identifier : AIDSLINE MED/96268534; Hoegl L; Ollert M; Korting HC; Department of Dermatology, Ludwig-Maximilians-University, Munich,; Germany.; Although Candida albicans infections in humans are increasingly frequent, our understanding of the host-parasite relationship is limited. The secreted aspartic proteinase of C. albicans was first described in 1965 and has proved to be a major factor in virulence. This enzyme belongs to the class of aspartic proteinase
[AIDS and childhood]: Bull Acad Natl Med. 1996 Mar;180(3):709-25. Unique Identifier : AIDSLINE MED/96327269; Courpotin C; Duche DJ; Unite de l'Immunodeficience Humaine, Hopital Armand-Trousseau,; Paris.
A trimeric structural domain of the HIV-1 transmembrane glycoprotein.: Nat Struct Biol. 1995 Dec;2(12):1075-82. Unique Identifier : AIDSLINE MED/96110868; Lu M; Blacklow SC; Kim PS; Howard Hughes Medical Institute, Department of Biology,; Massachusetts Institute of Technology, Cambridge 02142, USA.; Infection with HIV-1 is initiated by fusion of cellular and viral membranes. The gp41 subunit of the HIV-1 envelope plays a major role in this process, but the structure of gp41 is unknown. We have identified a stable, proteinase-resistant structure comprising two peptides, N-51 and C-43, derived from a recombinant pr
New drug class made available for AIDS treatment [news]: Am J Health Syst Pharm. 1996 Feb 1;53(3):226. Unique Identifier : AIDSLINE MED/96403736
Second protease inhibitor approved for HIV therapy [news]: Am J Health Syst Pharm. 1996 Apr 15;53(8):832. Unique Identifier : AIDSLINE MED/96362807
Bereavement is associated with time-dependent decrements in cellular immune function in asymptomatic human immunodeficiency virus type 1-seropositive homosexual men.: Clin Diagn Lab Immunol. 1996 Jan;3(1):109-18. Unique Identifier : AIDSLINE MED/96366337; Goodkin K; Feaster DJ; Tuttle R; Blaney NT; Kumar M; Baum MK; Shapshak P; Fletcher MA; Department of Psychiatry, University of Miami School of Medicine,; Florida 33136-1045, USA. kgoodkin@mednet.med.miami.edu; Seventy-nine human immunodeficiency virus type 1 (HIV-1)-seropositive homosexual men participating in a longitudinal study of HIV-1 infection were assessed twice, 6 months apart, to investigate associations between bereavement and cellular immune function. Subjects were assessed by using a theory-driven model comprisi
Immunoglobulin and complement complexes in blood following infection with human immunodeficiency virus type 1.: Clin Diagn Lab Immunol. 1996 Jan;3(1):128-31. Unique Identifier : AIDSLINE MED/96366339; Peng XX; Wainberg MA; Tao Y; Brenner BG; Department of Biological Science and Technology, Nanchang; University, People's Republic of China.; Freely soluble and complexed plasma immunoglobulin A (IgA), IgG, IgM, C1q, C3, and factor B in 36 human immunodeficiency virus type I (HIV-1)-seronegative controls, 69 asymptomatic HIV+ subjects, and 117 individuals with symptomatic HIV-associated disease were characterized. Levels of free and complexed IgG and IgA, a
Predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users.: Clin Diagn Lab Immunol. 1996 Jan;3(1):51-60. Unique Identifier : AIDSLINE MED/96366327; Page JB; Lai S; Fletcher MA; Patarca R; Smith PC; Lai HC; Klimas NG; Department of Psychiatry, University of Miami, Florida 33136,; USA.; In an ongoing prospective study of street-recruited intravenous drug users (IDUs) in Miami, Fla., 116 human immunodeficiency virus type 1 (HIV-1)-infected IDUs were monitored for up to 7 years. This provided an opportunity to evaluate baseline immunological parameters as potential predictors of survival among HIV-1-in
Targeting of retroviral vectors through protease-substrate interactions.: Gene Ther. 1996 Apr;3(4):280-6. Unique Identifier : AIDSLINE MED/96303670; Nilson BH; Morling FJ; Cosset FL; Russell SJ; Cambridge Centre for Protein Engineering, MRC Centre, UK.; Targetable, injectable vectors would greatly facilitate the development of in vivo therapy strategies. Viral and nonviral vectors can be targeted through ligand-receptor interactions, but protease-substrate interactions have not previously been exploited for vector targeting. Epidermal growth factor (EGF) was fused to
Expression of chimeric envelope proteins in helper cell lines and integration into Moloney murine leukemia virus particles.: Gene Ther. 1996 Apr;3(4):334-42. Unique Identifier : AIDSLINE MED/96303676; Schnierle BS; Moritz D; Jeschke M; Groner B; Institute for Experimental Cancer Research, Tumor Biology Center,; Freiburg, Germany.; New retroviral constructs with a grafted specificity of infection could become useful gene delivery vehicles with applications in systemic gene therapy. We have constructed retroviral vectors to target gene transfer to human tumor cells. Chimeric envelope proteins have been expressed to obtain viral particles with a d
Expression of mutant and wild-type gag proteins for gene therapy in HIV-1 infection.: Gene Ther. 1996 Apr;3(4):357-61. Unique Identifier : AIDSLINE MED/96303679; Miele G; Lever AM; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, UK.; The effect of expression of defective HIV-based retroviral constructs in CD4-positive lymphocytes on subsequent infection of the cell by HIV-1 was studied. A vector containing a N terminally elongated gag protein which was noncleavable and myristoylation negative was not effective at inhibiting HIV assembly or viral r
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.: Immunity. 1996 Sep;5(3):285-93. Unique Identifier : AIDSLINE MED/96404501; Lenschow DJ; Herold KC; Rhee L; Patel B; Koons A; Qin HY; Fuchs E; Singh B; Thompson CB; Bluestone JA; Ben May Institute for Cancer Research, Department of Pathology; and the Committee on Immunology, University of Chicago, Illinois; 60637, USA.; CD28 ligation delivers a costimulatory signal important in T cell activation. This study demonstrates that the disruption of the CD28/B7 pathway early in the nonobese diabetic mouse strain, using CD28-/- and CTLA41g transgenic mice, promoted the development and progression of spontaneous autoimmune diabetes. Functiona
Regulation of cytokine and chemokine transcription in a human TH2 type T-cell clone during the induction phase of anergy.: Clin Exp Allergy. 1996 Jan;26(1):20-7. Unique Identifier : AIDSLINE MED/96381526; O'Hehir RE; Lake RA; Schall TJ; Yssel H; Panagiotopoulou E; Lamb JR; Department of Immunology, St Mary's Hospital Medical School,; London, UK.; BACKGROUND: Selected cytokines produced by allergen specific CD4+ T cells from atopic individuals contribute to both the specific and non-specific effector mechanisms of the allergic immune response. The chemokine family of cytokines and tumour necrosis factor (TNF)-alpha are leucocyte regulatory and proinflammatory m
[Pleural empyema caused by Cryptococcus neoformans in a patient with liver cirrhosis]: Gastroenterol Hepatol. 1996 Jun-Jul;19(6):302-4. Unique Identifier : AIDSLINE MED/96345809; Sort P; Morales M; Gomez J; Pares A; Rodes J; Servicios de Hepatologia, Hospital Clinic i Provincial,; Barcelona.; Gram negative infections, particularly by E. coli, are usually observed in cirrhotic patients while infections by Cryptococcus neoformans are commonly found in immunosuppressed patients. The case of a cirrhotic patient with hepatitis C virus infection who developed pleural infection by C. neoformans is presented. No d
Why screen for HIV infection in pregnancy? [editorial; comment]: J Med Screen. 1994 Jul;1(3):143. Unique Identifier : AIDSLINE MED/96382642; Newell ML
Use of anonymous newborn serosurveys to evaluate antenatal HIV screening programmes [see comments]: J Med Screen. 1994 Jul;1(3):176-9. Unique Identifier : AIDSLINE MED/96382648; Holland FJ; Ades AE; Davison CF; Parker S; Berry T; Hjelm M; Wilcox AH; Cubitt D; Hudson CN; Peckham CS; Department of Epidemiology and Biostatistics, Institute of Child; Health, London, United Kingdom.; OBJECTIVE: To evaluate the extent to which antenatal HIV screening programmes identify HIV infected women who go to term. DESIGN: Comparison of results of two surveillance systems. An anonymous neonatal HIV serosurvey was used to estimate the numbers of HIV infected women giving birth; reporting by obstetricians was u
AIDS in position to ravage India [news]: Nat Med. 1996 Sep;2(9):951. Unique Identifier : AIDSLINE MED/96376335; Jayaraman KS
HIV-1 Tat protein as a potential AIDS vaccine.: Nat Med. 1996 Sep;2(9):960-4. Unique Identifier : AIDSLINE MED/96376337; Goldstein G; Department of Pathology, New York University School of Medicine,; USA.
Resistance to HIV-1 infection: it's in the genes.: Nat Med. 1996 Sep;2(9):966-7. Unique Identifier : AIDSLINE MED/96376339; Fauci AS; National Institute of Allergy and Infectious Diseases, National; Institutes of Health Bethesda, Maryland 20892, USA.
[A model of the structure of the receptor apparatus of HIV target cells (1)]: Lik Sprava. 1995 Jul-Aug;(7-8):155-9. Unique Identifier : AIDSLINE MED/96224785; Volianskii IuL; Telepneva LG; Vasil'ev NV; A model is proposed and well based of structure of the receptor apparatus of interacting HIV target cells: Langerhans cells (LC) and helper cells (HC)--designed to explain feasibility of realizing a double activation signal, together with some features of immune pathogenesis of HIV-infection (morphofunctional abnormal
Harm-reduction strategies weapon of choice in BC's battle with drug addiction.: Can Med Assoc J. 1996 Sep 1;155(5):571-3. Unique Identifier : AIDSLINE MED/96397370; Kent H; British Columbia, which holds the dubious distinction of being the country s heroin capital, has introduced a number of programs in an attempt to reduce the number of drug-overdose deaths. A BC coroner who headed a provincial government task force into overdose fatalities in 1994 has recommended a number of harm-reduc
Visit to Zambia offers humbling reminder of privileges Canadians enjoy.: Can Med Assoc J. 1996 Sep 1;155(5):579-80. Unique Identifier : AIDSLINE MED/96397372; Needham D; McMaster University medical student Dale Needham is spending 6 months in Zambia , where he is focusing on HIV/AIDS research. He describes the home environment of two of his Zambian colleagues, who recently travelled to Vancouver to attend the XI International AIDS Conference.
Bacillary angiomatosis.: Clin Dermatol. 1996 May-Jun;14(3):295-9. Unique Identifier : AIDSLINE MED/96330682; Manders SM; Department of Medicine, University of Medicine and Dentistry of; New Jersey, Robert Wood Johnson Medical School at Camden 08053,; USA.
Complementary therapies in HIV disease.: Altern Ther Health Med. 1996 Jul;2(4):42-6. Unique Identifier : AIDSLINE MED/96388521; Kaiser JD; Donegan E; Conant Medical Group Wellness Center, San Francisco, Calif., USA.; This study was designed to determine whether a standardized program of complementary therapies combined with appropriate standard medical care would have a measurable influence on the course of HIV disease when compared with data from other groups. All 10 participants began this study in 1988 with a diagnosis of asymp
Therapeutic radiology: a potential unfolding through bioelectromagnetic sciences.: Altern Ther Health Med. 1996 Sep;2(5):49-55. Unique Identifier : AIDSLINE MED/96388536; Jacobson JI; Institute of Theoretical Physics and Advanced Studies for; Biophysical Research, Jupiter, Fla., USA.; Clinical and experimental research in the area of bioelectromagnetics is reviewed and considered from a physical standpoint. An equation relating the intrinsic or rest energy of a charged particle with its energy of interaction in an externally applied magnetic field is proposed. This equation is intended to represe
Cerebritis due to Listeria monocytogenes: CT and MR findings.: Eur Radiol. 1996;6(2):188-91. Unique Identifier : AIDSLINE MED/96391004; Aladro Y; Ponce P; Santullano V; Angel-Moreno A; Santana MA; Department of Neurology, Hospital Nuestra Senora del Pino, Las; Palmas de Gran Canaria, Spain.; Infections by Listeria monocytogenes are uncommon, with cerebritis being even rarer. We present three cases of cerebritis which occurred during an outbreak of listeriosis. The CT and MR findings at diagnosis and during follow-up are described. Predominant deep white matter lesions with nodular and ring enhancement wer
Epidemiological studies in Japan.: J Epidemiol. 1996 Aug;6(3 Suppl):S13-7. Unique Identifier : AIDSLINE MED/96393482; Hirohata T; Department of Food and Nutrition Sciences, Nakamura Gakuen; University, Fukuoka, Japan.; The present article provides an overview of epidemiological studies in Japan . The origin of modern epidemiology of Japan can be traced back into the late 19th century. Baron K. Takaki at that time made brilliant epidemiological studies on beriberi and was thus able to eradicate the
Epidemiology of AIDS/HIV in Japan.: J Epidemiol. 1996 Aug;6(3 Suppl):S67-74. Unique Identifier : AIDSLINE MED/96393489; Tajima K; Soda K; Division of Epidemiology, Aichi Cancer Center Research Institute,; Nagoya, Japan.; The data obtained from the national reporting system of acquired immune deficiency syndrome (AIDS) and its causative immune deficiency virus (HIV), the epidemic pattern of AIDS cases and HIV carriers in Japan from 1985 to 1995 could be summarized as follows: 1) the total number of r
Transporting therapeutics across the blood-brain barrier.: Mol Med Today. 1996 Mar;2(3):106-13. Unique Identifier : AIDSLINE MED/96389571; Abbott NJ; Romero IA; Biomedical Sciences Division, King's College London, UK.; nj.abbott@kcl.ac.uk; In 1996, we are half-way through the Decade of the Brain, yet we still have few effective treatments for major disorders of the central nervous system. These include affective disorders, epilepsy, neurodegenerative disorders, brain tumours, infections and HIV encephalopathy; sufferers far outnumber the morbidity of ca
Testosterone wasting and AIDS [news]: Mol Med Today. 1996 Mar;2(3):93. Unique Identifier : AIDSLINE MED/96389567; Holzman D
Differential and antagonistic effects of v-Jun and c-Jun.: Cancer Res. 1996 Sep 15;56(18):4229-35. Unique Identifier : AIDSLINE MED/96390611; Gao M; Morgan I; Vogt PK; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, California 92037, USA.; We compared the ability of cellular and viral Jun (c-Jun and v-Jun) to transactivate target genes. c-Jun and v-Jun bind specifically to 12-O-tetradecanoylphorbol-13-acetate responsive elements [TREs, also called activator protein 1 (AP-1) motifs]. However, whereas c-Jun activates TRE-controlled promoters, v-Jun repres
Construction of phosphorylatable monoclonal antibody to a tumor-associated antigen.: Cancer Res. 1996 Sep 15;56(18):4250-4. Unique Identifier : AIDSLINE GENBANK/J00228; Lin L; Daugherty B; Schlom J; Pestka S; Department of Molecular Genetics and Microbiology, University of; Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical; School, Piscataway 08854-5635, USA.; A phosphorylation site was introduced into chimeric monoclonal antibody B72.3 (MAb-chB72.3) by site-specific mutation of the coding sequence. The phosphorylation site for the cAMP-dependent protein kinase was positioned at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3. The resultant modified
The XVIII Symposium of the International Association for Comparative Research on Leukemia & Related Diseases (IACRLRD): leukemia and lymphoma/pathogenesis and treatment/molecular aspects.: Cancer Res. 1996 Sep 15;56(18):4288-92. Unique Identifier : AIDSLINE MED/96390624; Jeang KT; Rauscher FJ 3rd; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases/NIH, Bethesda, Maryland 20892-0460, USA.
Differential human immunodeficiency virus risk factors among female general nurses, nurse midwives and office workers/teachers in Zambia.: Cent Afr J Med. 1996 Apr;42(4):114-7. Unique Identifier : AIDSLINE MED/96383945; Siziya S; Hakim JG; Department of Community Medicine, Medical School, University of; Zimbabwe, Avondale, Harare, Zimbabwe.; OBJECTIVES: To determine whether the factors associated with human immunodeficiency virus (HIV) infection are the same among the general nurses, nurse midwives and office workers/teachers. DESIGN: Cross sectional. SETTING: Schools, offices and hospitals. SUBJECTS: A total of 370 consenting females from each of the stu
Risk assessment and other screening options for gonorrhoea and chlamydial infections in women attending rural Tanzanian antenatal clinics.: Bull World Health Organ. 1995;73(5):621-30. Unique Identifier : AIDSLINE MED/96114347; Mayaud P; Grosskurth H; Changalucha J; Todd J; West B; Gabone R; Senkoro K; Rusizoka M; Laga M; Hayes R; et al; Department of Clinical Sciences, London School of Hygiene and; Tropical Medicine, England.; Sexually transmitted diseases (STDs) are a major cause of morbidity and mortality in developing countries and may play a key role in enhancing the heterosexual transmission of human immunodeficiency virus (HIV). Treatment of STDs is one of the most cost-effective of all health interventions in developing countries; ho
Clinical features of adrenal insufficiency in patients with acquired immunodeficiency syndrome.: Clin Endocrinol (Oxf). 1996 Jul;45(1):97-101. Unique Identifier : AIDSLINE MED/96388745; Piedrola G; Casado JL; Lopez E; Moreno A; Perez-Elias MJ; Garcia-Robles R; Department of Endocrinology, Hospital Ramon y Cajal, Madrid,; Spain.; OBJECTIVE: Adrenal insufficiency (AI) is a well known complication of AIDS. However, the clinical and biochemical features of AI in HIV infected patients have not been extensively studied. DESIGN: A retrospective clinical study. PATIENTS: We reviewed clinical records of 74 AIDS patients with clinical and/or biochemica
Th1 and Th2 in human diseases.: Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):225-35. Unique Identifier : AIDSLINE MED/96406955; Romagnani S; Division of Clinical Immunology and Allergy, University of; Florence, Italy.; A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functio
HIV-1 gp160 induces transforming growth factor-beta production in human PBMC.: Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):283-9. Unique Identifier : AIDSLINE MED/96406962; Hu R; Oyaizu N; Than S; Kalyanaraman VS; Wang XP; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine secreted by many mononuclear cells in peripheral blood (PBMC) and has diverse effects on cellular and humoral immunity. Increased TGF-beta mRNA expression has been reported in PBMC of HIV-infected patients, but the mechanism by which HIV induces
HIV-1 gp 120 blocks jacalin-induced proliferative response in CD4+ T cells: jacalin as a useful surrogate marker for qualitative and quantitative deficiency of CD4+ T cells in HIV-1 infection.: Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):290-7. Unique Identifier : AIDSLINE MED/96406963; Tamma SM; Oyaizu N; McCloskey TW; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; Jacalin is a plant lectin that induces mitogenic responses selectively in CD4+ T lymphocytes and has been shown to block infection by the human immunodeficiency virus type 1 (HIV-1) in a T lymphoid cell line, but the relationship of jacalin to the HIV envelope glycoprotein gp 120 in its interaction with the CD4 molecu
Differences in immune functions between human T-lymphotropic virus type I carriers and patients with adult T-cell leukemia/lymphoma.: Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):325-32. Unique Identifier : AIDSLINE MED/96406968; Funai N; Shimamoto Y; Yoshida S; Nagai Y; Nakazato S; Kohashi O; Department of Internal Medicine, Saga Medical School, Japan.; A variety of immunologic tests were compared between human T-lymphotropic virus type I (HTLV-I) carriers and patients with adult T-cell leukemia/lymphoma (ATL). The mitogenic responses of the lymphocytes to concanavalin A and phytohemagglutinin were depressed in the ATL patients but not in the carriers, while the resp
HBsAg in the kidneys of patients with HIV-associated nephropathy (HIVAN) [letter]: Clin Nephrol. 1996 Feb;45(2):133-4. Unique Identifier : AIDSLINE MED/96238277; Lopes GS; Rioja LS; de Oliveira CA; Santos Oda R
Immunopathogenesis and detection of HIV infection in women and newborns.: Clin Obstet Gynecol. 1996 Jun;39(2):277-91. Unique Identifier : AIDSLINE MED/96319223; Smith DK; Rogers MF; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
Epidemiology of HIV infection in women and newborns.: Clin Obstet Gynecol. 1996 Jun;39(2):292-304. Unique Identifier : AIDSLINE MED/96319224; Gwinn M; Wortley PM; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
Routine voluntary antepartum HIV antibody counseling and testing: a sound public health prevention strategy.: Clin Obstet Gynecol. 1996 Jun;39(2):305-15. Unique Identifier : AIDSLINE MED/96319225; Lindsay MK; Emory University, Atlanta, Georgia 30303, USA.; Routine voluntary antepartum HIV antibody counseling and testing are important HIV prevention strategies based on sound public health principles. The ultimate goal of this testing strategy is two-fold: identification of high-risk seronegative women for risk reduction counseling; and identification of HIV-infected part
Substance abuse and HIV pregnancy.: Clin Obstet Gynecol. 1996 Jun;39(2):316-32. Unique Identifier : AIDSLINE MED/96319226; Sprauve ME; Emory University, School of Medicine, Atlanta, Georgia 30303,; USA.; Substance abuse is a significant risk factor for HIV in pregnancy. Most substances can have deleterious effects on perinatal outcome, and in pregnancies complicated by maternal HIV infection, substance abuse may contribute to the rate of vertical transmission and the progression of maternal disease. Therefore, pregnan
Reproductive decision-making and determinants of contraceptive use in HIV-infected women.: Clin Obstet Gynecol. 1996 Jun;39(2):333-43. Unique Identifier : AIDSLINE MED/96319227; Williams HA; Watkins CE; Risby JA; Grady Memorial Hospital, Atlanta, Georgia 30335-3801, USA.; Perinatal transmission and reproductive decisions of HIV-infected women can be categorized in statistical and epidemiological terms. These reports and figures, however, do little to fully explain the complexities of human relationships, life experiences, personal and cultural influences, and situational and environmen
Management of HIV infection for the childbearing age woman.: Clin Obstet Gynecol. 1996 Jun;39(2):344-60. Unique Identifier : AIDSLINE MED/96319228; Bardeguez AD; UMDNJ-New Jersey Medical School, Newark 07103, USA.
The role of antiretroviral therapy in the management of HIV infection in women.: Clin Obstet Gynecol. 1996 Jun;39(2):361-85. Unique Identifier : AIDSLINE MED/96319229; Mofenson LM; National Institutes of Health, Rockville, Maryland, USA.
Determinants of perinatal HIV-1 transmission.: Clin Obstet Gynecol. 1996 Jun;39(2):386-95. Unique Identifier : AIDSLINE MED/96319230; Orloff SL; Simonds RJ; Steketee RW; St Louis ME; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
The diagnosis and management of perinatal HIV infection.: Clin Obstet Gynecol. 1996 Jun;39(2):396-410. Unique Identifier : AIDSLINE MED/96319231; Nesheim SR; Emory University, Atlanta, Georgia 30303, USA.
Common ethical dilemmas encountered in the management of HIV-infected women and newborns.: Clin Obstet Gynecol. 1996 Jun;39(2):411-9. Unique Identifier : AIDSLINE MED/96319232; Chervenak FA; McCullough LB; New York Hospital, Cornell Medical Center, New York 10021, USA.; The clinical management of the HIV-infected pregnant woman and newborns involves multifaceted ethical challenges. We have argued that rights-based approaches, based on a civil rights model, are not adequate to clinically address these challenges. We have argued instead for a more nuanced ethical framework that emphasi
Neonatal hepatobiliary disorders.: Clin Perinatol. 1996 Jun;23(2):321-52. Unique Identifier : AIDSLINE MED/96374681; Andres JM; Department of Pediatrics, University of Florida College of; Medicine, Shands Hospital, Gainesville, USA.; Neonatal hepatobiliary disorders are now better understood due primarily to new discoveries in molecular genetics, virology, and immunology. Because they are almost always pathologic and require early intervention, the neonatologist must recognize infants with these hepatocellular and ductal cholestatic problems occur
Analysis of receptors for cytokines and growth factors in human disease.: Dis Markers. 1996 Mar;12(4):225-40. Unique Identifier : AIDSLINE MED/96309118; Zola H; Child Health Research Institute, Adelaide, Australia.; The physiological importance of cytokines and other factors which control cell and tissue growth and differentiation is widely appreciated. While physiological studies have included the cellular receptors for these factors, studies on their role in disease have concentrated on the measurement of cytokines themselves o
Sonographic prediction of a normal or abnormal ERCP in suspected AIDS related sclerosing cholangitis.: Clin Radiol. 1996 Sep;51(9):618-21. Unique Identifier : AIDSLINE MED/96406574; Daly CA; Padley SP; Department of Radiology, Chelsea & Westminster Hospital, London,; UK.; AIM: We have assessed the ability of ultrasound to predict an abnormal ERCP examination in patients with suspected AIDS related Sclerosing Cholangitis (ARSC). PATIENTS AND METHODS: The ultrasound (US) and ERCP findings of fifty patients with clinically suspected AIDS cholangiopathy were reviewed. The diagnosis was sus
[The application of a new diagnostic protocol for stroke in the young]: Clin Ter. 1996 Apr;147(4):155-60. Unique Identifier : AIDSLINE MED/96344560; Moccia F; Colla G; Castelli F; Aramini A; Montobbio P; Altomonte F; Greco GM; Departimento d'Emergenza, Medicina d'Urgenza e Pronto Soccorso,; Ospedale S. Martino di Genova.; Cerebral infarction before the age of 45 years accounts for 4-6% of all strokes. The etiology remains unexplained in a significant proportion of patients even after extensive investigations. The reported risk factors of this age group are cardiopathies, hypertension, smoking, hypercholesterolemia, reduction of anticoa
Age-related changes of glycosidases in human retinal pigment epithelium.: Curr Eye Res. 1996 Apr;15(4):433-8. Unique Identifier : AIDSLINE MED/96309103; Cingle KA; Kalski RS; Bruner WE; O'Brien CM; Erhard P; Wyszynski RE; Administration Medical Center, Case Western Reserve University,; Cleveland 44106, USA.; This study was undertaken to determine whether there are age-related changes in the specific activities of several glycosidases in fresh retinal pigment epithelial cells (RPE) isolated from the posterior pole of human donor eyes. One hundred and twenty-one pairs of eyes from human donors, between the ages of 43 and 95
Morphological and ultrastructural changes induced in corneal epithelial cells by HIV-1 and HHV-6 in vitro.: Curr Eye Res. 1996 Jun;15(6):597-604. Unique Identifier : AIDSLINE MED/96324341; Qavi HB; Xu B; Green MT; Lusso P; Pearson G; Ablashi DV; Division of Molecular Virology, Baylor College of Medicine,; Houston, TX 77030, USA.; PURPOSE. The purpose of this study was to determine whether HIV-1 and HHV-6 are capable of infecting and inducing morphological and ultrastructural changes in corneal epithelial cells in vitro. METHODS. Primary and transformed corneal epithelial cell cultures were infected with HIV-1 or HHV-6 in vitro and analyzed for
Familial Kaposi's sarcoma.: Cutis. 1996 Apr;57(4):220-2. Unique Identifier : AIDSLINE MED/96285824; Perniciaro C; Gross DJ; White JW Jr; Adrian RM; Department of Dermatology, Mayo Clinic Jacksonville, Florida,; USA.; Familial cases of Kaposi s sarcoma are exceedingly rare. We identified an 85-year-old man with Kaposi s sarcoma. Multiple lesions were present on the feet. Previously, the man s 84-year-old sister presented with similar lesions on the lower extremity. Both siblings were lifelong residents of the
Blue nails and acquired immunodeficiency syndrome: not always associated with azidothymidine use.: Cutis. 1996 Apr;57(4):243-4. Unique Identifier : AIDSLINE MED/96285830; Glaser DA; Remlinger K; Division of Dermatology, Saint Louis University School of; Medicine, Missouri, USA.; Nail dyschromia in patients infected with human immunodeficiency virus (HIV) was first described in 1987 by Furth and Kazakis. It has since been reported in many patients with the acquired immunodeficiency syndrome (AIDS), predominantly in those taking azidothymidine. There have been only three reports of nail pigment
Diarrhea and quality of life in ambulatory HIV-infected patients.: Dig Dis Sci. 1996 Sep;41(9):1794-800. Unique Identifier : AIDSLINE MED/96387261; Watson A; Samore MH; Wanke CA; Division of Infectious Diseases, Deaconess Hospital, Boston,; Massachusetts, USA.; Our objectives were to determine HIV-infected patients awareness and recognition of diarrheal symptoms; and to assess the impact of diarrhea on quality of life. The design was a cross-sectional study utilizing a structured telephone interview. The setting was the HIV/AIDS outpatient clinic of a tertiary referral hosp
[HIV: virus burden as a prognostic factor and for monitoring of therapy (news)]: Dtsch Med Wochenschr. 1996 Sep 6;121(36):A9. Unique Identifier : AIDSLINE MED/96441006; Schenk M
Alcohol's effects on requisites for sexual risk reduction in men: an initial experimental investigation.: Health Psychol. 1996 Jan;15(1):56-60. Unique Identifier : AIDSLINE MED/96380528; Gordon CM; Carey MP; Department of Psychology, Syracuse University, New York; 13244-2340, USA.; The effects of alcohol intoxication on mediators of condom use were examined in a laboratory-based experiment. Twenty men were randomly assigned to either an alcohol or a nonalcohol beverage administration condition. Participants in the experimental condition drank vodka and tonic to achieve a blood alcohol level of 0
Identification of two novel arginine binding DNAs.: EMBO J. 1995 Dec 1;14(23):5798-811. Unique Identifier : AIDSLINE MED/96112795; Harada K; Frankel AD; Department of Biochemistry and Biophysics, University of; California at San Francisco 94143-0448, USA.; RNA tertiary structure is known to play critical roles in RNA-protein recognition and RNA function. To examine how DNA tertiary structure might relate to RNA structure, we performed in vitro selection experiments to identify single-stranded DNAs that specifically bind arginine, and compared the results with analogous
The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.: EMBO J. 1995 Dec 1;14(23):5995-6009. Unique Identifier : AIDSLINE GENBANK/U38847; Wu-Baer F; Lane WS; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235-8594, USA.; Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element located downstream of the transcription initiation site known as TAR. To characterize cellular factors that bind to TAR RNA and are involved in the regulation of HIV-1 transcription, HeLa nuclear extract was fractio
The effects of altered exercise distribution on lymphocyte subpopulations.: Eur J Appl Physiol. 1995;72(1-2):157-64. Unique Identifier : AIDSLINE MED/96381574; Host CR; Norton KI; Olds TS; Lowe EL; Mulligan SP; Faculty of Nursing, University of Sydney, Camperdown N.S.W.,; Australia.; The effects of exercise distribution on lymphocyte count, lymphocyte subpopulations and plasma cortisol concentration in peripheral blood were assessed in 19 healthy subjects. The subjects were randomly divided into group A (n = 10) or group B (n = 9) according to exercise distribution. Both groups underwent a 10-week
Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells.: Eur J Immunol. 1996 Aug;26(8):1700-6. Unique Identifier : AIDSLINE MED/96350486; Wolthers KC; Otto SA; Lens SM; Kolbach DN; van Lier RA; Miedema F; Meyaard L; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; T cells express CD28 and CD27 which transduce co-stimulatory signals after interaction with their ligands on antigen-presenting cells (APC). These ligands, CD80, CD86 and CD70, are also expressed to some extent on activated T cells. Here, we show that in human immunodeficiency virus (HIV)-infected individuals, CD28 an
Expression of an avian CD6 candidate is restricted to alpha beta T cells, splenic CD8+ gamma delta T cells and embryonic natural killer cells.: Eur J Immunol. 1996 Aug;26(8):1743-7. Unique Identifier : AIDSLINE MED/96350492; Gobel TW; Chen CH; Cooper MD; Basel Institute for Immunology, Switzerland. goebel@bii.ch; A candidate avian CD6 homolog is identified by the S3 monoclonal antibody. The S3 antigen exists in a phosphorylated glycoprotein form of 130 kDa and a nonphosphorylated form of 110 kDa. Removal of phosphate groups and N-linked carbohydrates indicates a 78-kDa protein core. During thymocyte differentiation, the gamma
The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus.: Eur J Immunol. 1996 Aug;26(8):1762-9. Unique Identifier : AIDSLINE MED/96350495; Wang B; Gonzalez A; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et Cellulaire; (CNRS/INSERM/ULP) Illkirch, C.U. de Strasbourg, France.; While it is generally accepted that T cells are critical for the development of diabetes in the non-obese diabetic (NOD) mouse, the precise functions of the CD4+ and CD8+ subsets remain ill-defined. Transfer experiments have provided evidence that CD4+ cells are the disease initiators, provoking massive mononuclear le
Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef gene.: Eur J Immunol. 1996 Aug;26(8):1788-93. Unique Identifier : AIDSLINE MED/96350499; Collette Y; Mawas C; Olive D; INSERM, Unite 119, Marseilles, France.; Infection by human immunodeficiency virus (HIV)-1 is associated with quantitative and qualitative T cell alterations that severely impair the host s immune defense system. The molecular basis for this immunosuppression remains unclear. Peripheral blood mononuclear cells (PBMC) isolated from patients show markedly decr
Heterogeneous effects of B7-1 and B7-2 in the induction of both protective and therapeutic anti-tumor immunity against different mouse tumors.: Eur J Immunol. 1996 Aug;26(8):1851-9. Unique Identifier : AIDSLINE MED/96350508; Martin-Fontecha A; Cavallo F; Bellone M; Heltai S; Iezzi G; Tornaghi P; Nabavi N; Forni G; Dellabona P; Casorati G; Unita d'Immunochimica, DIBIT, Istituto Scientifico San Raffaele,; Milano, Italy.; Experimental mouse tumors are classified as intrinsically immunogenic when, after a single injection into syngeneic mice as nonreplicating cell vaccines, they elicit a protective immune response against a subsequent lethal challenge. Tumors that do not retain this residual immunogenicity are defined as poorly immunoge
In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production.: Eur J Immunol. 1996 Sep;26(9):2062-6. Unique Identifier : AIDSLINE MED/96409265; Brewer JM; Conacher M; Satoskar A; Bluethmann H; Alexander J; Department of Immunology, University of Strathclyde, Glasgow,; Scotland.; The role of interleukin (IL)-4 in the activity of two frequently used vaccine adjuvants, Freund s complete adjuvant (FCA) and the aluminum hydroxide gels (alum), was studied using the standard antigen ovalbumin (OVA) in IL-4 genedisrupted mice (IL-4 -/-). In the absence of adjuvant, there was an overall reduction in a
Selective stimulation of T helper 2 cytokine responses by the anti-psoriasis agent monomethylfumarate.: Eur J Immunol. 1996 Sep;26(9):2067-74. Unique Identifier : AIDSLINE MED/96409266; de Jong R; Bezemer AC; Zomerdijk TP; van de Pouw-Kraan T; Ottenhoff TH; Nibbering PH; Department of Immunohematology and Bloodbank, University Hospital; Leiden, The Netherlands.; Type 2 cytokines are thought to have a protective role in psoriasis vulgaris by dampening the activity of T helper 1 (Th1) lymphocytes. The aim of the present study was to determine the effect of monomethylfumarate (MMF), the most active metabolite of the new anti-psoriatic drug Fumaderm, on the production of cytokine
Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.: Eur J Immunol. 1996 Sep;26(9):2181-8. Unique Identifier : AIDSLINE MED/96409283; Di Somma MM; Majolini MB; Burastero SE; Telford JL; Baldari CT; Department of Evolutionary Biology, University of Siena, Italy.; The CD4 co-receptor interacts with nonpolymorphic regions of major histocompatibility complex class II molecules on antigen-presenting cells. This interaction results in the mobilization of a number of signaling mediators shared by the T cell receptor (TcR) signaling pathway and thus amplifies TcR-generated signals. W
DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies.: Exp Cell Res. 1996 Aug 1;226(2):292-301. Unique Identifier : AIDSLINE MED/96400057; Shimizu T; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; We studied the role of proteases in apoptosis using a cell-free system prepared from a human leukemia cell line. HL60 cells are p53 null and extremely sensitive to a variety of apoptotic stimuli including DNA damage induced by the topoisomerase I inhibitor, camptothecin. We measured DNA fragmentation induced in isolat
Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics.: Eur Respir J. 1996 Mar;9(3):456-62. Unique Identifier : AIDSLINE MED/96279991; Jaffar ZH; Sullivan P; Page C; Costello J; Dept of Thoracic Medicine, King's College Hospital, London, UK.; Theophylline has been shown by several investigators to attenuate the late asthmatic response (LAR) to inhaled allergen, suggesting that it has anti-inflammatory or immunomodulatory properties. We have, therefore, undertaken a double-blind, placebo-controlled study to examine the effects of low-dose theophylline on br
Surfactant protein-A levels increase during Pneumocystis carinii pneumonia in the rat.: Eur Respir J. 1996 Mar;9(3):565-70. Unique Identifier : AIDSLINE MED/96280008; Phelps DS; Umstead TM; Rose RM; Fishman JA; Dept of Pediatrics, Pennsylvania State University College of; Medicine, Hershey 17033, USA.; In bronchoalveolar lavage (BAL) of human immunodeficiency virus (HIV)-infected patients with Pneumocystis carinii pneumonia and in lungs of glucocorticoid-immunosuppressed rats infected with P. carinii, surfactant phospholipid levels are reduced. However, levels of the surfactant-associated protein-A (SP-A) in BAL are
Surface analysis of IgM-expressing bovine lymphocytes in BLV-infected cattle by immuno-scanning electron microscopy.: Folia Histochem Cytobiol. 1996;34(1):31-4. Unique Identifier : AIDSLINE MED/96369479; Levkut M; Ponti W; Levkutova M; Turin L; Poli G; Department of Pathological Anatomy, University of Veterinary; Medicine, Kosice, Slovakia.; Surface of IgM-expressing lymphocytes infected by bovine leukemia virus and with/without persistent lymphocytosis (BLV+PL-, BLV+PL+) in cattle is heterogenous. Three distinct morphological structures of B lymphocytes were found in these groups by immuno-scanning electron microscopy (ISEM). B lymphocytes with generally
Intrauterine death and infections during pregnancy.: Int J Gynaecol Obstet. 1995 Dec;51(3):211-8. Unique Identifier : AIDSLINE MED/96363219; Moyo SR; Tswana SA; Nystrom L; Bergstrom S; Blomberg J; Ljungh A; Department of Medical Microbiology, University of Zimbabwe; Medical School, Harare.; OBJECTIVE: To elucidate whether microbial infections are involved in the etiology of intrauterine death. METHODS: One hundred four cases of stillbirth of unknown etiology and 96 age- and parity-matched referents with live births were analyzed with respect to microbial infection by cultures from the placenta, endocervi
Granuloma inguinale in association with pregnancy and HIV infection.: Int J Gynaecol Obstet. 1996 May;53(2):133-8. Unique Identifier : AIDSLINE MED/96323668; Hoosen AA; Mphatsoe M; Kharsany AB; Moodley J; Bassa A; Bramdev A; Department of Medical Microbiology, Faculty of Medicine,; University of Natal, Durban, South Africa.; OBJECTIVES: A retrospective study to confirm the clinical impression of an increasing prevalence of granuloma inguinale (GI) in women, and to evaluate its association with pregnancy and HIV infection. METHODS: Clinical records of all patients with a definitive diagnosis of GI attending the gynecology and antenatal cli
Vitiligo in Vogt-Koyanagi-Harada disease: immunohistological analysis of inflammatory site.: Graefes Arch Clin Exp Ophthalmol. 1996 Jun;234(6):359-63. Unique Identifier : AIDSLINE MED/96338583; Okada T; Sakamoto T; Ishibashi T; Inomata H; Department of Ophthalmology, Faculty of Medicine, Kyushu; University, Fukuoka, Japan.; BACKGROUND: Vogt-Koyanagi-Harada disease (VKH) consists of uveitis with associated non-ocular symptoms, such as vitiligo or central nervous system disorders. A cell-mediated immune disorder is believed to play an important role in VKH; however, the skin lesion has not been well studied. Therefore, for this study, we e
The new lymphotropic herpesviruses (HHV-6, HHV-7, HHV-8) and hepatitis C virus (HCV) in human lymphoproliferative diseases: an overview.: Haematologica. 1996 May-Jun;81(3):265-81. Unique Identifier : AIDSLINE MED/96311938; Luppi M; Torelli G; Department of Medical Sciences, University of Modena, Italy.; Considerable evidence has been accumulating in favor of a possible involvement of viral agents in the pathogenesis of human lymphomas. The most recent proposal for a lymphoma classification, the Revised European-American Classification, emphasized for the first time the pathogenetic importance of two viruses, namely E
[Acquired immunodeficiency syndrome--1995 (Part I)]: Harefuah. 1995 Dec 1;129(11):520-5. Unique Identifier : AIDSLINE MED/96204752; Lasry Y; Bentwich Z
Review of the biology of Quercetin and related bioflavonoids.: Food Chem Toxicol. 1995 Dec;33(12):1061-80. Unique Identifier : AIDSLINE MED/96112558; Formica JV; Regelson W; Department of Microbiology and Immunology, School of Medicine,; Virginia Commonwealth University, Richmond 23298-0678, USA.; The French paradox is a dietary anomaly which has focused attention on the Mediterranean diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium and Brassica vegetables, and red wine), correlated with the increased longevity and decreased incidence of cardiovascular disease seen
Effect of surgically induced hypoestrinism on immunoregulation in perimenopausal women.: Horm Metab Res. 1996 Apr;28(4):187-9. Unique Identifier : AIDSLINE MED/96311529; Zofkova I; Kancheva RL; Institute of Endocrinology, Prague, Czech Republic.; The object of the present study was to investigate the effect of bilateral oophorectomy (OOX) on CD4+ and CD8+ subsets of T-lymphocytes in 8 immunologically healthy perimenopausal women with regular bleeding. Between the 12th and 16th week after OOX, CD8+ (%) increased in all of the investigated women (mean values com
HIV-1 gp41 selectively inhibits spontaneous cell proliferation of human cell lines and mitogen- and recall antigen-induced lymphocyte proliferation.: Immunol Lett. 1995 Nov;48(1):39-44. Unique Identifier : AIDSLINE MED/96247060; Chen YH; Christiansen A; Dierich MP; Ludwig-Boltzmann-Institute for AIDS Research, University of; Innsbruck, Austria.; Human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein 41 (gp41) contains an immunosuppressive domain (Env amino acids 583-599). Previous studies by us and others using recombinant soluble gp41 (rsgp41; amino acids 539-684) and immunosuppressive peptide (1SP; a gp41 peptide, amino acids 583-599) have s
Detection of human IgG antibodies against free N-acetyl-L-cysteine.: Immunol Lett. 1995 Nov;48(1):49-52. Unique Identifier : AIDSLINE MED/96247062; Maes RF; Anda Biologicals, Strasbourg, France.; Human antibodies of the IgG type reacting with free N-acetyl-cysteine are detectable with an appropriate immunoconjugate. Free cysteine, homocysteine and glutathione, but not cystine, interfere with the antibodies. The interference with cysteine and homocysteine is frequently reduced after nitrosylation of these amino
Effect of additional oral ofloxacin administration in the treatment of multidrug-resistant tuberculosis.: Indian J Chest Dis Allied Sci. 1996 Apr-Jun;38(2):73-9. Unique Identifier : AIDSLINE MED/96419941; Sharma SK; Guleria R; Jain D; Chawla TC; Saha P; Mohan A; Jain NK; Department of Medicine, All India Institute of Medical Science,; New Delhi; The effect of additional oral ofloxacin administration was evaluated in 19 HIV-negative patients with multidrug-resistant tuberculosis (MDR-TB). Their mean duration of illness was 3.6 years. Based on chest roentgenograms, 13 patients had advanced disease and 6 had moderate disease. In addition to second-line drugs ,
Ocular lesions in AIDS: a report of first two cases in India.: Indian J Ophthalmol. 1995 Jun;43(2):69-72. Unique Identifier : AIDSLINE MED/96415388; Biswas J; Madhavan HN; Badrinath SS; Sankara Nethralaya, Medical Research Foundation, Madras.; Although 444 cases of AIDS have been officially registered till July 1993 from various parts of India , ocular lesions in these cases have not been reported. Till May 1994, ELISA test for HIV 1 and HIV 2 had been done in 12 cases of suspicious ocular lesions which include viral retin
Malignant lymphoma induction in rabbits by intravenous inoculation of Epstein-Barr-virus-related herpesvirus from HTLV-II-transformed cynomolgus leukocyte cell line (Si-IIA).: Int J Cancer. 1995 Dec 11;63(6):872-80. Unique Identifier : AIDSLINE MED/96112172; Hayashi K; Koirala TR; Ino H; Chen HL; Ohara N; Teramoto N; Yoshino T; Takahashi K; Yamada M; Nii S; et al; Department of Pathology, Okayama University Medical School,; Japan.; Malignant lymphomas, which were usually of T-cell type, were induced in 10 of 13 (77%) male rabbits (Japanese white, 8/10; New Zealand white, 2/3) inoculated i.v. with HTLV-II-transformed simian (Cynomolgus) leukocyte cell line (Si-IIA) cells. Of 7 rabbits injected with cell-fr
Wellness and HIV: developing a model for progression from theoretical knowledge about psychosocial factors to application.: Int J Immunopharmacol. 1995 Aug;17(8):663-76. Unique Identifier : AIDSLINE MED/96115787; Rayner-Brosnan D; Department of Psychiatry, University of Queensland, Herston,; Brisbane, Australia.; Psychosocial factors and immunological markers have been associated not only with progression from HIV to AIDS and AIDS survival, but also with wellness. Not yet identified, and therefore not yet formalized into a system for clinical decision-making, are those individual differences that moderate both the impact of ps
Infection with Penicillium marneffei.: Int J Dermatol. 1996 Jun;35(6):393-9. Unique Identifier : AIDSLINE MED/96353691; Wortman PD; Department of Dermatology, Wake Forest University Medical Center,; Winston-Salem, North Carolina 27157-1071, USA.
Adult T-cell leukemia/lymphoma cutaneous type.: Int J Dermatol. 1996 Jun;35(6):400-1. Unique Identifier : AIDSLINE MED/96353692; Nagatani T; Department of Dermatology, Yokohama City University School of; Medicine, Japan.
Porokeratosis of Mibelli and HIV-infection.: Int J Dermatol. 1996 Jun;35(6):402-4. Unique Identifier : AIDSLINE MED/96353693; Rodriguez EA; Jakubowicz S; Chinchilla DA; Carril A; Viglioglia PA; Department of Dermatology, Hospital General de Agudos, Juan A.; Fernandez, School of Medicine, University of Buenos Aires,; Argentina.; BACKGROUND: The exacerbation of porokeratosis of Mibelli associated with inmunosuppression has been well documented. MATERIALS AND METHODS: We describe the clinical and histologic data of three cases of HIV-infected patients, who developed porokeratosis following HIV-contact. RESULTS: The three reported patients were
Jordanian and Canadian nursing students' knowledge about AIDS.: Int Nurs Rev. 1996 May-Jun;43(3):89-92. Unique Identifier : AIDSLINE MED/96369534; al-Ma'aitah R; Gignac D; Rajacich D; Faculty of Nursing, University of Science and Technology, Irbid,; Jordan.; With the current HIV/AIDS epidemic unchecked and as yet no known cure or vaccine, it is critical that students be prepared to care for AIDS patients. Thus nursing schools must teach them full data on the disease, prevention and universal precautions.
Surgical helmet systems.: Health Devices. 1996 Apr;25(4):116-45. Unique Identifier : AIDSLINE MED/96283262; A surgical helmet system (SHS) is either a loose-fitting hood or a hood combined with an integral gown (called a toga system). SHSs are used during orthopedic procedures to decrease the patient s risk of deep wound infection by keeping skin and other particles from the surgeon s face from falling into the open surgica
The effects of formalin fixation on the detection of apoptosis in human brain by in situ end-labelling of DNA.: Histochem J. 1995 Dec;27(12):983-8. Unique Identifier : AIDSLINE MED/96381386; Davison FD; Groves M; Scaravilli F; Department of Neuropathology, Institute of Neurology, Queen; Square, London, UK.; The technique of DNA in situ end-labelling (ISEL) for the detection of apoptotic cells has recently become the method of choice. The incorporation of a labelled nucleotide to facilitate detection into the single-stranded region of DNA cleaved by endogenous nucleases has proved to be a sensitive and straightforward tec
An HLA class I peptide-binding assay based on competition for binding to class I molecules on intact human B cells. Identification of conserved HIV-1 polymerase peptides binding to HLA-A*0301.: Hum Immunol. 1995 Dec;44(4):189-98. Unique Identifier : AIDSLINE MED/96366454; van der Burg SH; Ras E; Drijfhout JW; Benckhuijsen WE; Bremers AJ; Melief CJ; Kast WM; Department of Immunohaematology and Bloodbank, University; Hospital, Leiden, The Netherlands.; A peptide-binding assay employing the HLA class I molecules on intact human B cells is described. The peptide antigens are stripped from the HLA class I molecules by mild acid treatment, after which the cells are incubated with a FL-labeled reference peptide together with different concentrations of the peptide of int
Clinical profile of AIDS in India: a review of 61 cases.: J Assoc Physicians India. 1995 Aug;43(8):535-8. Unique Identifier : AIDSLINE MED/96368965; Chacko S; John TJ; Babu PG; Jacob M; Kaur A; Mathai D; Dept of Medicine, Christian Medical College and Hospital,; Vellore, Tamilnadu, India.; Among 61 patients with AIDS seen in our hospital from February 1986 to June 1992, 38 (62%) had significant weight loss, 34 (56%) had fever of more than a month and 19 (31%) had chronic diarrhoea; 43 (70%) patients had at least one of the above symptoms. Tuberculosis diagnosed in 32 (52%) patients was the commonest sec
HIV infection and leprosy--an enigma.: J Assoc Physicians India. 1995 Aug;43(8):557-9. Unique Identifier : AIDSLINE MED/96368970; Sankaran JR
[Does laparoscopic surgery affect immunity?]: J Chir (Paris). 1996 Apr;133(2):51-3. Unique Identifier : AIDSLINE MED/96306406; Champault G; Bron M; Catheline JM; Mercadier A; Service de Chirurgie Generale et Digestive (Pr. G. Champault),; Hopital Jean-Verdier, Bondy.; In a prospective study including 20 laparoscopic cholecystectomies, markers of the humoral (immunoglobuline) and cell mediated (lymphocytes and sub population T4/T8) have been assessed on 1st, 3nd and 8th post-operative days. There is no significant variation (except total lymphocyte count) within the limits of normal
University of Southern California Repeatable Episodic Memory Test.: J Clin Exp Neuropsychol. 1995 Dec;17(6):926-36. Unique Identifier : AIDSLINE MED/96245869; Parker ES; Eaton EM; Whipple SC; Heseltine PN; Bridge TP; Center for Neuropsychology, Irvine, California.; The University of Southern California Repeatable Episodic Memory Test (USC-REMT) was developed to provide a brief assay of memory in clinical drug trials where the same subject is tested multiple times over days or weeks. Therefore, it had to be minimally affected by repeated testing. The test also provides a measure
Encephalocytozoon intestinalis-specific monoclonal antibodies for laboratory diagnosis of microsporidiosis.: J Clin Microbiol. 1996 Feb;34(2):282-5. Unique Identifier : AIDSLINE MED/96380988; Beckers PJ; Derks GJ; Gool T; Rietveld FJ; Sauerwein RW; Department of Medical Microbiology, University Hospital Nijmegen,; Netherlands.; Two monoclonal antibodies which can be used for the unambiguous identification by fluorescence microscopy of Encephalitozoon intestinalis spores in clinical specimens are described. Monoclonal antibody Si91 is specific for the extruded polar filament, and Si13 recognizes the surfaces of E. intestinalis spores. No cros
Application of a commercial kit for detection of PCR products to quantification of human immunodeficiency virus type 1 RNA and proviral DNA.: J Clin Microbiol. 1996 Feb;34(2):329-33. Unique Identifier : AIDSLINE MED/96380996; Lin HJ; Haywood M; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030, USA. lin@bcm.tmc.edu; Quantitative tests for human immunodeficiency virus type 1 (HIV-1) RNA in plasma and proviral DNA in peripheral blood mononuclear cells (PBMC) provide valuable information on the status of HIV-1 infection. This paper describes tests that were carried out with commercially available materials and an enzyme-linked immun
Typing of Mycobacterium avium isolates by PCR.: J Clin Microbiol. 1996 Feb;34(2):389-92. Unique Identifier : AIDSLINE MED/96381008; Picardeau M; Vincent V; Laboratoire de Reference des Mycobacteries, Institut Pasteur,; Paris, France.; A Mycobacterium avium typing method based on PCR amplification of genomic sequences located between the recently described repetitive elements IS1245 and IS1311 was developed. This method was applied to a set of epidemiologically related and unrelated strains and compared with restriction fragment length polymorphism
Quantification of low levels of human immunodeficiency virus (HIV) type 1 RNA in P24 antigen-negative, asymptomatic, HIV-positive patients by PCR.: J Clin Microbiol. 1996 Feb;34(2):404-8. Unique Identifier : AIDSLINE MED/96381011; Munoz-Fernandez MA; Navarro J; Montes MG; Cosin J; Zabay JM; Fernandez-Cruz E; A nested PCR was used to quantify small numbers of human immunodeficiency virus (HIV) type 1 (HIV-1) RNA particles in the serum specimens of 26 p24 antigen-negative, asymptomatic, HIV-positive patients undergoing antiretroviral therapy. Fifteen patients received zidovudine (ZDV) and alpha interferon, and 11 patients r
High-level sensitivity of quantitative pp65 cytomegalovirus (CMV) antigenemia assay for diagnosis of CMV disease in AIDS patients and follow-up.: J Clin Microbiol. 1996 Feb;34(2):457-9. Unique Identifier : AIDSLINE MED/96381026; Bek B; Boeckh M; Lepenies J; Bieniek B; Arasteh K; Heise W; Deppermann KM; Bornhoft G; Stoffler-Meilicke M; Schuller I; Hoffken G; Division of Cardiopulmonology, Universitatsklinikum Benjamin; Franklin, Berlin, Germany.; Cytomegalovirus ( CMV ) antigenemia was evaluated in 174 patients positive for human immunodeficiency virus. Antigenemia could be detected in 96.7% of patients with CMV disease, 76.9% of patients suffering from a relapse of the disease, and 11.4% of asymptomatic p
Primary invasive cutaneous Microsporum canis infections in immunocompromised patients.: J Clin Microbiol. 1996 Feb;34(2):460-2. Unique Identifier : AIDSLINE MED/96381027; King D; Cheever LW; Hood A; Horn TD; Rinaldi MG; Merz WG; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, Maryland 21287-7093.; Two cases of primary invasive cutaneous infections caused by the zoophilic dermatophytic species Microsporum canis are presented. The first case occurred in a liver transplant recipient who was receiving immunosuppressive therapy. Multiple erythematous papules were seen on both legs, and a biopsy revealed invasive fun
New PCR assay for rapid and quantitative detection of human cytomegalovirus in cerebrospinal fluid.: J Clin Microbiol. 1996 Feb;34(2):482-3. Unique Identifier : AIDSLINE MED/96381034; Vogel JU; Cinatl J; Lux A; Weber B; Driesel AJ; Doerr HW; Institute of Medical Virology, JWG-University Frankfurt,; Frankfurt am Main, Germany.; Rapid Chelex extraction combined with an automated hybridization assay for the detection of PCR-amplified human cytomegalovirus DNA from cerebrospinal fluid was established. Quantitation of DNA was performed with a plasmid being used as an external standard. The detection limit was
Comparative evaluation of NASBA HIV-1 RNA QT, AMPLICOR-HIV monitor, and QUANTIPLEX HIV RNA assay, three methods for quantification of human immunodeficiency virus type 1 RNA in plasma.: J Clin Microbiol. 1996 May;34(5):1058-64. Unique Identifier : AIDSLINE MED/96284398; Revets H; Marissens D; de Wit S; Lacor P; Clumeck N; Lauwers S; Zissis G; Aids Referentielaboratorium, Vrije Universiteit Brussel, Belgium.; Three commercial assays for quantifying plasma human immunodeficiency virus type 1 (HIV-1) RNA were evaluated. The assays differed in their sample volumes, the means of preparing samples, and methods of amplification and detection. Plasma samples were obtained from 36 HIV-1-infected patients representing all stages of
Evaluation of Amplicor MTB test as adjunct to smears and culture for direct detection of Mycobacterium tuberculosis in the French Caribbean.: J Clin Microbiol. 1996 May;34(5):1065-8. Unique Identifier : AIDSLINE MED/96284399; Devallois A; Legrand E; Rastogi N; Institut Pasteur, Pointe a Pitre, Guadelooupe, French West; Indies.; A total of 784 specimens collected from 370 individuals between January and August 1995 were analyzed by using the Amplicor Mycobacterium tuberculosis test (Roche Diagnostic System, Basel, Switzerland ), a PCR-based test for the direct detection of organisms of the M. tuberculo
Typing Candida albicans oral isolates from human immunodeficiency virus-infected patients by multilocus enzyme electrophoresis and DNA fingerprinting.: J Clin Microbiol. 1996 May;34(5):1235-48. Unique Identifier : AIDSLINE MED/96284433; Boerlin P; Boerlin-Petzold F; Goudet J; Durussel C; Pagani JL; Chave JP; Bille J; Institute of Microbiology, University Hospital, Lausanne,; Switzerland.; A total of 189 Candida albicans isolates have been typed by multilocus enzyme electrophoresis. The results obtained confirm the clonal mode of reproduction of C. albicans. The C. albicans populations found in the oropharynx of human immunodeficiency virus (HIV)-infected patients, in the oropharynx of healthy carriers,
Multicenter evaluation of broth microdilution method for susceptibility testing of Cryptococcus neoformans against fluconazole.: J Clin Microbiol. 1996 May;34(5):1280-2. Unique Identifier : AIDSLINE MED/96284442; Sanati H; Messer SA; Pfaller M; Witt M; Larsen R; Espinel-Ingroff A; Ghannoum M; Department of Medicine, Harbor-UCLA Medical Center, Torrance,; USA.; We have developed a microdilution method for measuring the susceptibility of Cryptococcus neoformans to fluconazole. The present study evaluated the interlaboratory agreement of the results for the microdilution method obtained at three different sites and compared this method with the National Committee for Clinical
Improved detection of JC virus DNA in cerebrospinal fluid for diagnosis of AIDS-related progressive multifocal leukoencephalopathy.: J Clin Microbiol. 1996 May;34(5):1343-6. Unique Identifier : AIDSLINE MED/96284461; de Luca A; Cingolani A; Linzalone A; Ammassari A; Murri R; Giancola ML; Maiuro G; Antinori A; Department of Infectious Diseases, Catholic University, Rome; Italy.; Several methods to increase the sensitivity of JC virus (JCV) DNA detection in cerebrospinal fluid (CSF) for a noninvasive diagnosis of AIDS-related progressive multifocal leukoencephalopathy (PML) were investigated. When CSF collected at clinical presentation was tested, JCV DNA was detected in 8 of 19 patients with
100% mortality of non-AIDS patients with Pneumocystis carinii pneumonia (PCP) requiring mechanical ventilation (MV) [letter]: Intensive Care Med. 1995 Sep;21(9):777-8. Unique Identifier : AIDSLINE MED/96115702; Schweigart U; Huber W; Scherf J
CD45 isoforms on human CD4+ T-cell subsets.: J Allergy Clin Immunol. 1996 Aug;98(2):433-40. Unique Identifier : AIDSLINE MED/96347967; Shanafelt MC; Yssel H; Soderberg C; Steinman L; Adelman DC; Peltz G; Lahesmaa R; Department of Leukocyte Biology, Syntex Research (Roche; Bioscience), Palo Alto, California, USA.; We have examined the level of surface expression and functional properties of leukocyte function associated antigen-1, very late antigen-4, and CD45 isoforms on a panel of human CD4+ T-cell clones representative of TH0, TH1, and TH2 cells. There were no qualitative differences in the expression of these antigens among
Fulminant herpes colitis in a patient with Crohn's disease.: J Clin Gastroenterol. 1996 Apr;22(3):220-3. Unique Identifier : AIDSLINE MED/96320872; el-Serag HB; Zwas FR; Cirillo NW; Eisen RN; Greenwich Hospital, Yale Medical School, Connecticut, USA.; Herpes simplex virus (HSV) is a well-recognized cause of gastrointestinal infection, most commonly in patients with underlying immunodeficiency. The esophagus, perianum, and rectum are the most common sites of involvement; however, extensive colitis is rare. We describe a woman with Crohn s disease who developed patho
Interleukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement.: Immunol Res. 1996;15(1):1-15. Unique Identifier : AIDSLINE MED/96320760; Kinter A; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, Md,; USA.; A hallmark of human immunodeficiency virus (HIV) infection is the progressive loss of CD4+ T lymphocytes; however, qualitative defects in immune responses occur prior to the precipitous drop CD4+ T cell numbers. One of the first immunologic defects to be described in HIV-infected individuals is a deficiency in interle
Immunosuppression through blockade of CD28:B7-mediated costimulatory signals.: Immunol Res. 1996;15(1):38-49. Unique Identifier : AIDSLINE MED/96320763; Judge TA; Tang A; Turka LA; Department of Medicine, University of Pennsylvania, Philadelphia; 19104-6069, USA.; It is now well established that T cells require two signals for activation and effector function. The first signal is provided through the T cell receptor for antigen. The best-characterized pathway which provides the second, or costimulatory, signal is through the CD28 receptor on the surface of T cells. In vitro, li
Graft-versus-host disease and the Th1/Th2 paradigm.: Immunol Res. 1996;15(1):50-73. Unique Identifier : AIDSLINE MED/96320764; Krenger W; Ferrara JL; Division of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, Mass 02115, USA.; Graft-versus-host disease (GVHD) is the major complication after allogeneic bone marrow transplantation (BMT) and is initiated by alloreactive donor T cells recognizing foreign histocompatibility antigens of the host. There is now substantial experimental and clinical evidence to implicate a dysregulation of cytokine
Immunomodulation of peripheral T cells in chickens infected with Marek's disease virus: involvement in immunosuppression.: J Gen Virol. 1995 Dec;76 ( Pt 12):2979-85. Unique Identifier : AIDSLINE MED/96112183; Morimura T; Hattori M; Ohashi K; Sugimoto C; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Sapporo, Japan.; Marek s disease virus (MDV) causes T cell immunosuppression in chickens during latent infection. Morphological changes specific to apoptosis were demonstrated in peripheral blood mononuclear cells (PBMC) of MDV-infected chickens at 2-3 weeks post-inoculation (p.i.). Analysis of DNA fragmentation in T cell subsets in t
Targeted infection of a retrovirus bearing a CD4-Env chimera into human cells expressing human immunodeficiency virus type 1.: J Gen Virol. 1995 Dec;76 ( Pt 12):3165-9. Unique Identifier : AIDSLINE GENBANK/X02794; Matano T; Odawara T; Iwamoto A; Yoshikura H; Department of Bacteriology, Faculty of Medicine, University of; Tokyo, Japan.; We constructed a hybrid Moloney murine leukaemia virus (MoMLV) bearing both a chimeric CD4 and the wild-type MoMLV envelope protein (Env) on its surface. The chimeric molecule, consisting of a surface domain of CD4 and the C-terminal two-thirds of MLV Env, was expressed on the cell surface. When expressed in MoMLV-inf
Role of the C terminus Gag protein in human immunodeficiency virus type 1 virion assembly and maturation.: J Gen Virol. 1995 Dec;76 ( Pt 12):3171-9. Unique Identifier : AIDSLINE MED/96112206; Yu XF; Matsuda Z; Yu QC; Lee TH; Essex M; Department of Molecular Microbiology and Immunology, Johns; Hopkins School of Hygiene and Public Health, Baltimore, MD 21205,; USA.; Lentiviral Gag polyproteins have a proline-rich protein, p6, at their C terminus. There are conflicting reports about the function of p6 in virus release. In the present work, mutants that affect p6 of human immunodeficiency virus type 1 (HIV-1) Gag polyprotein were constructed and analysed. None of the mutants preven
Determination of the inactivation kinetics of hepatitis A virus in human plasma products using a simple TCID50 assay.: J Med Virol. 1996 May;49(1):1-6. Unique Identifier : AIDSLINE MED/96310231; Barrett PN; Meyer H; Wachtel I; Eibl J; Dorner F; Immuno AG, Biomedical Research Center, Orth a.d. Donau, Austria.; The transmission of hepatitis A virus (HAV) associated with use of FVIII concentrates has been reported in a number of European countries. All of these cases were associated with products inactivated by use of solvent detergent treatment. These reports have emphasized the necessity of evaluating virus inactivation met
Sensitive detection and quantification of particle-associated reverse transcriptase in plasma of HIV-1-infected individuals by the product-enhanced reverse transcriptase (PERT) assay.: J Med Virol. 1996 May;49(1):23-8. Unique Identifier : AIDSLINE MED/96310234; Boni J; Pyra H; Schupbach J; Swiss National Center for Retroviruses, University of Zurich,; Switzerland.; Tests for the enzyme reverse transcriptase (RT) should permit the detection of all infectious retroviruses, provided that these are present as extracellular particles. The capability of a new procedure, named product-enhanced reverse transcriptase (PERT) assay, to detect HIV-1 in fresh human plasma was compared with t
Value of laboratory investigations in clinical suspicion of cytomegalovirus-induced upper gastrointestinal tract ulcerations in HIV-infected patients.: J Med Virol. 1996 May;49(1):29-33. Unique Identifier : AIDSLINE MED/96310235; Dorigo-Zetsma JW; van der Meer JT; Tersmette M; ten Kate FJ; Wertheim-van Dillen PM; van der Noordaa J; Department of Clinical Virology, Academic Medical Center,; Amsterdam, The Netherlands.; To assess the value of laboratory investigations for the diagnosis and treatment of cytomegalovirus-induced upper gastrointestinal tract ulcerations, the medical records and biopsy material from HIV-infected patients were reviewed retrospectively during a 12-month period. Clinical diagnosis of cytomegalovirus (
Analysis of ENV V3 sequences from HIV-1-infected brain indicates restrained virus expression throughout the disease.: J Med Virol. 1996 May;49(1):41-8. Unique Identifier : AIDSLINE MED/96310225; Di Stefano M; Gray F; Leitner T; Chiodi F; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.; The isolation of human immunodeficiency virus type 1 (HIV-1) from the cerebrospinal fluid (CSF) of asymptomatic virus carriers suggests that the viral infection spreading to the brain occurs early during infection. The aim of the present study was to investigate whether HIV-1 infection of the brain parenchyma also occ
Chronic delta hepatitis: is the prognosis worse when associated with hepatitis C virus and human immunodeficiency virus infections?: J Med Virol. 1996 May;49(1):66-9. Unique Identifier : AIDSLINE MED/96310229; Buti M; Jardi R; Allende H; Cotrina M; Rodriguez F; Viladomiu L; Esteban R; Guardia J; Department of Hepatology, Hospital General Universitario Valle; Hebron, Barcelona, Spain.; Eighty-six patients were followed for 6.5 years to study the epidemiological, virological, and histological course of chronic delta hepatitis and the relationship of this disease with HIV and HCV infection. Patients were classified into four groups according to simultaneous HCV and/or HIV infection: group 1, HDV infec
Structure-activity correlation study of HIV-1 inhibitors: electronic and molecular parameters.: J Comput Aided Mol Des. 1996 Apr;10(2):145-52. Unique Identifier : AIDSLINE MED/96304802; Hannongbua S; Lawtrakul L; Limtrakul J; Department of Chemistry, Faculty of Science, Kasetsart; University, Bangkok, Thailand.; Quantitative structure-activity relationships (QSARs) for 40 HIV-1 inhibitors, 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine and its derivatives, were studied. Fully optimized geometries, based on the semiempirical AMl method, were used to calculate electronic and molecular properties of all compounds. In order t
Molecular surface-volume and property matching to superpose flexible dissimilar molecules.: J Comput Aided Mol Des. 1995 Dec;9(6):479-90. Unique Identifier : AIDSLINE MED/96381177; Perkins TD; Mills JE; Dean PM; Department of Pharmacology, University of Cambridge, UK.; Steric complementarity is a prerequisite for ligand-receptor recognition; this implies that drugs with a common receptor binding site should possess sterically similar binding surfaces. This principle is used as the basis for an automatic and unbiased method that superposes molecules. One molecule is rotated and trans
Pneumocystis pneumonia in brain tumor patients: risk factors and clinical features.: J Neurooncol. 1996 Mar;27(3):235-40. Unique Identifier : AIDSLINE MED/96267450; Schiff D; Department of Neurology, Mayo Clinic, USA.; We reviewed the clinical features and risk factors for Pneumocystis carinii pneumonia (PCP) in patients with brain tumors (BTs) seen at our institution between 1980 and 1992. Previously rare, this opportunistic infection appears to be increasing among HIV-negative cancer patients receiving immunosuppressive medication
Characterization of dynamic state inhibitors of HIV-1 protease.: J Enzym Inhib. 1995;9(3):217-33. Unique Identifier : AIDSLINE MED/96116082; Vaillancourt M; Cohen E; Sauve G; Institut Armand-Frappier, Universite du Quebec, Laval, Canada.; The inhibitory behavior of simple N-protected amino acids containing a dysfunctional enol group was analyzed. Pseudo-Hill coefficients below 0.5 were obtained for the enol compounds. The active moiety of the enols described herein is involved in an equilibrium between keto and enol forms. The enol in its E form intera
Human immunodeficiency virus: healthcare worker safety issues.: J Intraven Nurs. 1996 May-Jun;19(3):132-40. Unique Identifier : AIDSLINE MED/96380818; McKee JM; Medical Unit, Trinity Lutheran Hospital, Kansas City, Missouri,; USA.; No country or social group is immune from acquiring the human immunodeficiency virus. Among healthcare workers, nurses account for a large percentage of people who seroconvert accidentally. This article will provide a review of the status of the acquired immune deficiency syndrome epidemic, discuss infection control g
Gender relations in addiction and recovery.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):325-37. Unique Identifier : AIDSLINE MED/96380676; Amaro H; Hardy-Fanta C; Department of Social and Behavioral Sciences, Boston University; School of Public Health, Massachusetts 02118, USA.; This article adds to the growing but still limited literature on the role of gender relations in women s addiction and recovery. In-depth interviews were conducted with 35 women randomly drawn from a large study of drug-abusing pregnant women who were recruited into an HIV/AIDS prevention program. These interviews exp
Level of burden: women with more than one co-occurring disorder.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):339-46. Unique Identifier : AIDSLINE MED/96380677; Brown VB; Huba GJ; Melchior LA; PROTOTYPES, Culver City, California 90230, USA.; Utilizing an expanded concept of level of burden, the impact of multiple problems experienced by women in a residential drug abuse treatment program on treatment retention and outcomes is investigated. Level of burden is defined in this study as the number and severity of problems, including psychological problems, co
Women living with drug abuse and HIV disease: drug abuse treatment access and secondary prevention issues.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):401-11. Unique Identifier : AIDSLINE MED/96380682; Weissman G; Melchior L; Huba G; Smereck G; Needle R; McCarthy S; Jones A; Genser S; Cottler L; Booth R; et al; Science and Epidemiology, BHRD, HRSA, Rockville, Maryland 20857,; USA.; In collaboration with the National Institute on Drug Abuse, the Health Resources and Services Administration is conducting a multisite, longitudinal study on issues of service needs, service utilization, and access to care for drug abusers with HIV. This article discusses access to drug abuse treatment and HIV seconda
Lesbian alcohol and marijuana use: correlates of HIV risk behaviors and abusive relationships.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):413-9. Unique Identifier : AIDSLINE MED/96380683; Perry SM; Drug Abuse Research Center, University of California, Los Angeles; 90024, USA.; One hundred fifty-two self-identified lesbian and bisexual women participated in an exploratory study of lesbian health and high-risk sexual behaviors. These women were primarily White, middle class, and college educated. The relationship of alcohol and marijuana use to high-risk sexual behaviors and involvement in pa
Ethnic differences in HIV risk behaviors, self-perceptions, and treatment outcomes among women in methadone maintenance treatment.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):421-33. Unique Identifier : AIDSLINE MED/96380684; Grella CE; Annon JJ; Anglin MD; Neuropsychiatric Institute, University of California, Los Angeles; 90024, USA.; This study examined the HIV risk profiles of White, African-American, and Latina women enrolled in the UCLA Enhanced Methadone Maintenance Project, a NIDA-funded research demonstration project with the goal of reducing risk of HIV infection and/or transmission. Each group demonstrated distinct patterns associated with
HIV-related risk behaviors and seropositivity among homeless drug-abusing women in Miami, Florida.: J Psychoactive Drugs. 1995 Oct-Dec;27(4):435-46. Unique Identifier : AIDSLINE MED/96380685; Metsch LR; McCoy CB; McCoy HV; Shultz JM; Lai S; Weatherby NL; McAnany H; Correa R; Anwyl RS; Department of Epidemiology and Public Health, University of Miami; School of Medicine, Florida 33136, USA.; This article examines the multifaceted interactions among homelessness, HIV, substance abuse, and gender. Data were collected on 1,366 chronic drug users using a nationally standardized validated instrument within the Miami CARES project of a multisite federally funded program. HIV testing accompanied by pretest and p
Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infection.: J Pediatr. 1996 Sep;129(3):390-5. Unique Identifier : AIDSLINE MED/96397434; Wang EE; Law BJ; Boucher FD; Stephens D; Robinson JL; Dobson S; Langley JM; McDonald J; MacDonald NE; Mitchell I; Department of Pediatrics, Hospital for Sick Children, Ontario.; OBJECTIVE: To describe differences in patients hospitalized with respiratory syncytial virus (RSV) lower respiratory tract infection (LRI) at nine Canadian tertiary care hospitals. In addition, this study describes the variation in use of drug and other interventions. METHODS: Data on patients hospitalized with RSV LR
Comparison of virus burden in blood and sequential lymph node biopsy specimens from children infected with human immunodeficiency virus.: J Pediatr. 1996 Sep;129(3):410-8. Unique Identifier : AIDSLINE MED/96397437; Mueller BU; Sei S; Anderson B; Luzuriaga K; Farley M; Venzon DJ; Tudor-Williams G; Schwartzentruber DJ; Fox C; Sullivan JL; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland 20892-1928, USA.; BACKGROUND: Lymph nodes serve as reservoirs for the replication of human immunodeficiency virus (HIV) type 1. Comparison of serial measurements of virus burden in lymph nodes and peripheral blood after a change in antiretroviral therapy may provide insights into pathogenic mechanisms and permit a more accurate assessm
Lymphocyte subsets and cell proliferation analysis in rabies-infected mice.: J Clin Lab Immunol. 1995;46(2):49-61. Unique Identifier : AIDSLINE MED/96381115; Cardenas Palomo LF; de Souza Matos DC; Chaves Leal E; Bertho AL; Marcovistz R; Departamento de Imunologia, Instituto Oswaldo Cruz, Rio de; Janeiro, Brasil.; Alterations to lymphocyte subsets in the thymus and spleen of rabies-infected mice were investigated in a kinetic study covering the entire course of infection. Changes in the levels of thymic Thy1.2 cells were found to be proportional to total thymocyte depletion, while thymic CD4-/CD8- and B cell subsets were observ
AIDS-like disease following mucosal infection of pig-tailed macaques with SIVsmmPBj14.: J Med Primatol. 1995 May;24(3):102-7. Unique Identifier : AIDSLINE MED/96288340; Fultz PN; Schwiebert R; Stallworth J; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170,; Following exposure of the rectal or vaginal mucosa to cell-free SIVsmmPBj14, four male and two female pig-tailed macaques developed a characteristic acute disease, including mucoid diarrhea, lymphopenia, and anorexia. Two macaques infected by the rectal route died within 14 days, and one female died of an AIDS-like di
Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.: J Med Primatol. 1995 May;24(3):108-15. Unique Identifier : AIDSLINE MED/96288341; Chen Z; Telfer P; Reed P; Zhang L; Getti A; Ho DD; Marx PA; Department of Microbiology, New York University Medical Center,; NY, 10016, US; The lineage of HIV-2-like viruses was studied in feral sooty mangabeys (SMs) by serological and genetic methods. Four feral sooty mangabeys were positive for simian immunodeficiency virus (SIV) antibodies and a new isolate, SIVsmSL92a, was obtained. Genetic analysis of gag genes showed that SIVsmSL92a was highly diver
Origins of simian immunodeficiency virus infection in macaques at the New England Regional Primate Research Center.: J Med Primatol. 1995 May;24(3):116-22. Unique Identifier : AIDSLINE MED/96288342; Mansfield KG; Lerch NW; Gardner MB; Lackner AA; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA, 01772, USA.; A cohort of rhesus macaques (Macaca mulatta), obtained from the California Regional Primate Research Center (CRPRC) and necropsied in 1970-72 with lesions suggestive of simian immunodeficiency virus (SIV) infection, was identified at the New England Regional Primate Research Center (NERPRC). Polymerase chain reaction
VCAM-1 expression and leukocyte trafficking to the CNS occur early in infection with pathogenic isolates of SIV.: J Med Primatol. 1995 May;24(3):123-31. Unique Identifier : AIDSLINE MED/96288343; Sasseville VG; Lane JH; Walsh D; Ringler DJ; Lackner AA; Division of Comparative Pathology, New England Regional Primate; Research Center, Harvard Medical School, Southborough, MA,; 01772-9102, USA.; This study reports on the endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) in the central nervous system (CNS) early after experimental infection of rhesus monkeys (Macaca mulatta) with pathogenic and nonpathogenic simian immunodeficiency virus (SIV). Diffuse endothelial expression of VCAM-1 was ob
Differences in viral distribution and cell adhesion molecule expression in the intestinal tract of rhesus macaques infected with pathogenic and nonpathogenic SIV.: J Med Primatol. 1995 May;24(3):132-40. Unique Identifier : AIDSLINE MED/96288344; Stone JD; Heise CC; Canfield DR; Elices MJ; Dandekar S; Department of Internal Medicine, University of California, Davis,; USA.; We investigated SIV infection and expression of adhesion molecules in the small intestine of rhesus macaques infected with pathogenic SIV (SIVmac) or nonpathogenic clone (SIV1A11). There was a wider dissemination and marked difference in tissue localization of SIVmac relative to SIV1A11. Our results also indicate that
Assessing genetic-based therapies for AIDS using the simian immunodeficiency virus.: J Med Primatol. 1995 May;24(3):141-4. Unique Identifier : AIDSLINE MED/96288345; Endres CL; Bergquam E; Axthelm MK; Wong SW; Division of Pathobiology and Immunology, Oregon Regional Primate; Research Center, Beaverton, USA.; A plasmid encoding the full-length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replicatio
Neutralising epitopes of simian immunodeficiency virus envelope glycoprotein.: J Med Primatol. 1995 May;24(3):145-9. Unique Identifier : AIDSLINE MED/96288346; Kent KA; National Institute for Biological Standards and Controls, Herts,; UK.; Monoclonal and polyclonal antibodies with weak SIV neutralising activity bind to the V2 and V4 regions of gp120 or bind to the amino acids DWNND in gp41. Antibodies with the most potent neutralising activity recognise conformation-dependent epitopes involving the V3 and V4 regions of gp120. Monoclonal antibodies that
Fourth annual survey of worldwide HIV, SIV, and SHIV challenge studies in vaccinated nonhuman primates.: J Med Primatol. 1995 May;24(3):150-68. Unique Identifier : AIDSLINE MED/96288347; Warren JT; Levinson MA; EMMES Corporation, Potomac, MD, USA.
13th annual symposium on nonhuman primate models for AIDS. Monterey, California, November 5-8, 1994. Abstracts.: J Med Primatol. 1995 Dec;24(4):169-229. Unique Identifier : AIDSLINE MED/96438555
Enumeration of lymphokine-secreting cells as a quantitative measure for cellular immune responses in rhesus macaques.: J Med Primatol. 1995 Dec;24(4):271-81. Unique Identifier : AIDSLINE MED/96352278; van der Meide PH; Groenestein RJ; de Labie MC; Heeney J; Pala P; Slaoui M; Biomedical Primate Research Center, Rijswijk, Netherlands.; We investigated whether enumeration of lymphokine-secreting T cells can be used as a quantitative measure to determine the immunogenicity of foreign proteins in rhesus monkeys. In addition, it was assessed whether this approach can supplement and/or substitute for the well-established lymphoproliferation assay. Two ca
Characterization of the natural immune response of rhesus monkey CD4+ve T cells to the bacterial antigen streptolysin O (SLO).: J Med Primatol. 1995 Dec;24(4):306-12. Unique Identifier : AIDSLINE MED/96352280; Kraakman EM; Bontrop RE; Groenestein R; Jonker M; Haaijman JJ; 't Hart BA; Department of Immunobiology, Biomedical Primate Research Centre,; Rijswijk, Netherlands.; Rhesus monkeys show a high proliferative T cell response to the bacterial exotoxin SLO without prior immunization. The present study was undertaken to characterize this naturally present SLO-responsiveness with particular emphasis on CD4+ve reactive T cells. It is demonstrated that the frequency of SLO-reactive cells
Primer selection by HIV-1 reverse transcriptase on RNA-tRNA(3Lys) and DNA-tRNA(3Lys) hybrids.: J Mol Biol. 1996 Aug 23;261(3):315-21. Unique Identifier : AIDSLINE MED/96374482; Yusupova G; Lanchy JM; Yusupov M; Keith G; Le Grice SF; Ehresmann C; Ehresmann B; Marquet R; Unite Propre de Recherche no. 9002 du Centre National de la; Recherche Scientifique Institut de Biologie Moleculaire et; Cellulaire, Strasbourg, France.; During reverse transcription of the genomic RNA of human immunodeficiency virus type 1 (HIV-1) into double-stranded DNA, reverse transcriptase (RT) must accommodate RNA-RNA, DNA-RNA, RNA-DNA and DNA-DNA hybrids as primer-template. In this study, we examined extension of RNA-tRNA3Lys, and DNA-tRNA3Lys complexes by HIV-
Efficient inhibition of transcription elongation in vitro by oligonucleotide phosphoramidates targeted to proviral HIV DNA.: J Mol Biol. 1996 Aug 23;261(3):386-98. Unique Identifier : AIDSLINE MED/96374490; Giovannangeli C; Perrouault L; Escude C; Gryaznov S; Helene C; Laboratoire de Biophysique Museum National d'Histoire Naturelle,; INSERM U.201-CNRS URA 481, Paris, France.; Triplex-forming oligophosphoramidates containing thymines and cytosines or 5-methyl cytosines (5 T4CT4C6T 3 ) bind strongly to a 16 basepair oligopurine.oligopyrimidine sequence of HIV proviral DNA even at neutral pH. These triple-helical complexes formed with oligonucleotide analogues with N3 -->P5 phosphoramidate
A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease.: J Mol Biol. 1996 Aug 23;261(3):454-69. Unique Identifier : AIDSLINE MED/96374495; Liu H; Muller-Plathe F; van Gunsteren WF; Laboratory of Physical Chemistry, Swiss Federal Institute of; Technology, ETHZ, Zurich, Switzerland.; Based on available three-dimensional structures of enzyme-inhibitor complexes, the mechanism of the reaction catalysed by HIV protease is studied using molecular dynamics simulations with molecular mechanics and combined quantum-mechanics/molecular-mechanics potential energy functions. The results support the general
Childhood AIDS nephropathy: a 10-year experience.: J Natl Med Assoc. 1996 Aug;88(8):493-8. Unique Identifier : AIDSLINE MED/96396310; Rajpoot D; Kaupke CJ; Vaziri ND; Rao TK; Pomrantz A; Fikrig S; Department of Pediatrics, University of California, Irvine, USA.; The objective of this study was to define the demographic, immunologic, and clinical characteristics of children with acquired immunodeficiency syndrome (AIDS) and AIDS nephropathy, and contrast this with the existing adult data. Data from 62 pediatric patients with AIDS who were treated at SUNY Health Science Center,
Dietary fish oil and cytokine and eicosanoid production during human immunodeficiency virus infection.: JPEN J Parenter Enteral Nutr. 1996 Jan-Feb;20(1):43-9. Unique Identifier : AIDSLINE MED/96380249; Bell SJ; Chavali S; Bistrian BR; Connolly CA; Utsunomiya T; Forse RA; Surgical Metabolism Laboratory, Deaconess Hospital, Boston, MA; 02215, USA.; BACKGROUND: Dietary fish oil (FO) has been shown to modulate the immune system. The purpose of this study was to explore the effects of FO supplementation on the production of dienoic eicosanoids and cytokines in patients with human immunodeficiency virus (HIV) infection. METHODS: This was a randomized, prospective, d
[Pneumocystis carinii pneumonia in a HTLV-I carrier with monoclonal proliferation of HTLV-I infected lymphocyte]: Rinsho Ketsueki. 1996 Apr;37(4):317-22. Unique Identifier : AIDSLINE MED/96244835; Kawahigashi N; Furukawa Y; Tara M; Niina K; Department of Internal Medicine, Kagoshima City Hospital.; A 63-year-old woman had Pneumocystis carinii pneumonia without any apparent underlying disease such as cancers or HIV infection. Although she reacted positively for HTLV-I antibody, hematological findings and clinical symptoms did not suggest that this patient had an ATL. Southern blot analysis revealed that HTLV-I in
Replication rate and evolution in the human immunodeficiency virus.: J Theor Biol. 1996 Jun 21;180(4):359-64. Unique Identifier : AIDSLINE MED/96372652; Kelly JK; Department of Ecology and Evolution, University of Chicago, IL; 60637, USA.; Population genetic and virological methods yield estimates for the mean replication rate of the Human Immunodeficiency Virus type 1 (HIV-1) that differ by six fold. I present a simple model that can reconcile the estimates obtained from each method by considering the role of intra-host population structure on viral dy
Elevated pim-1 and c-myc proto-oncogene induction in B lymphocytes from BLV-infected cows with persistent B lymphocytosis.: Leukemia. 1996 Oct;10(10):1629-38. Unique Identifier : AIDSLINE MED/96404370; Stone DM; Norton LK; Magnuson NS; Davis WC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99164-7040, USA.; Bovine leukemia virus (BLV) induces a non-malignant, polyclonal, persistent lymphocytosis (PL) of circulating, CD5 B lymphocytes in cattle, with variable progression to CD5 B cell leukemia or lymphoma. We analyzed the expression of two proto-oncogenes, pim-1 and c-myc, proto-oncogenes deregulated in some human B cell
Association of Epstein-Barr virus with human immunodeficiency virus-negative T cell lymphomas in Japan, in situ hybridization, polymerase chain reaction and immunohistochemical studies [letter]: Leukemia. 1996 Oct;10(10):1673-5. Unique Identifier : AIDSLINE MED/96404380; Hirose Y; Masaki Y; Shimizu S; Ogawa Y; Takeshita S; Fukutoku M; Sugai S; Takiguchi T
Treatment of woodchuck hepatitis virus infection in vivo with 2', 3'-dideoxycytidine (ddC) and 2',-3'-dideoxycytidine monophosphate coupled to lactosaminated human serum albumin (L-HSA ddCMP).: Liver. 1996 Apr;16(2):88-93. Unique Identifier : AIDSLINE MED/96303365; Zahm FE; d'Urso N; Bonino F; Ponzetto A; F.Hoffman La-Roche Ltd, Basel, Switzerland.; Dideoxycytidine ( ddC ) is a nucleoside analogue active against human immunodeficiency virus and with in vitro activity against human hepatitis B virus. We investigated the ability of ddC to inhibit one of the Hepadnaviridae, the woodchuck hepatitis vir
Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study.: Magn Reson Med. 1996 May;35(5):658-63. Unique Identifier : AIDSLINE MED/96302718; Christensen JD; Kaufman MJ; Levin JM; Mendelson JH; Holman BL; Cohen BM; Renshaw PF; Brain Imaging Center, McLean Hospital, Belmont, Massachusetts,; USA.; Phosphorus magnetic resonance spectroscopy (31P MRS) at 1.5 T was performed on nine polysubstance abusing men. All nine patients met DSM-III-R criteria for concurrent cocaine and heroin dependence, were neurologically normal, were negative for the human immunodeficiency virus, and had normal clinical brain MRI scans.
Targeting of chrolamphenicol acetyltransferase to human immunodeficiency virus particles via Vpr and Vpx.: Microbiol Immunol. 1995;39(12):1015-9. Unique Identifier : AIDSLINE MED/96381050; Sato A; Isaka Y; Kodama M; Yoshimoto J; Kawauchi S; Kuwata T; Adachi A; Hayami M; Yoshi O; Fujiwara T; Shionogi Institute for Medical Science, Settsu, Japan.; Vpr and Vpx are the auxiliary proteins of human immunodeficiency viruses (HIVs) selectively incorporated into mature viral particles. We showed that the bacterial chloramphenicol acetyltransferase (CAT) fused to the N-terminus of HIV-1 Vpr, HIV-2 Vpr, or HIV-2 Vpx was incorporated into mature virions in a type-selecti
Suppression of HIV-1 reverse transcriptase activity by culture supernatants of mycoplasmas.: Microbiol Immunol. 1995;39(12):987-93. Unique Identifier : AIDSLINE MED/96381045; Shang H; Miyakawa Y; Sasaki T; Nakashima H; Ito M; Department of Microbiology, Yamanashi Medical University, Japan.; Coinfection with mycoplasmas has been shown to enhance cytopathic changes in T lymphocytes in culture brought about by human immunodeficiency virus type-1 (HIV-1), accelerate disease progression, and suppress reverse transcriptase (RT) activity simultaneously. We attempted to identify the components in culture superna
Training medical students in HIV/AIDS test counselling: results of a randomized trial.: Med Educ. 1996 Mar;30(2):134-41. Unique Identifier : AIDSLINE MED/96297161; Campbell E; Weeks C; Walsh R; Sanson-Fisher R; Faculty of Medicine and Health Sciences, University of Newcastle,; Australia.; The study assessed the effectiveness of a programme aimed at increasing medical students skills in counselling patients presenting for HIV testing/AIDS information. Senior medical students were randomly assigned to receive a short course in pre- and post-test counselling, or to a control group which received the usua
Destruction of human immunodeficiency-infected cells by ferrofluid particles manipulated by an external magnetic field: mechanical disruption and selective introduction of cytotoxic or antiretroviral substances into target cells.: Med Hypotheses. 1996 Jan;46(1):5-12. Unique Identifier : AIDSLINE MED/96352000; Peasley KW; Submagnetic domain magnetic fluid particles of approximately 10 nm average diameter complexed with CD4 or monoclonal antibody and then injected into the patient, will localize to the cell membrane of the target cell. These ferrofluid particles will interact with an externally applied rotating magnetic field of rapidly
Managing HIV. Part 8: controlling an epidemic. 8.4 Protecting the blood supply from HIV.: Med J Aust. 1996 Sep 2;165(5):264-5. Unique Identifier : AIDSLINE MED/96413530; Wylie BR; Dodd RY; New South Wales Red Cross Blood Transfusion Service, Sydney.; Since 1985 the theoretical risk of HIV infection posed by medical treatment with blood products has been very low. There have been no known cases of HIV transmission via blood products in Australia since that time. Nevertheless, blood banks continue to examine new techniques for
Managing HIV. Part 8: Controlling an epidemic. 8.5 HIV prevention in the community: injecting drug users.: Med J Aust. 1996 Sep 2;165(5):266-7. Unique Identifier : AIDSLINE MED/96413531; Wodak A; Dolan K; Alcohol and Drug Services, St Vincent's Hospital, Sydney, NSW.; Increasing HIV transmission among drug users has often been the prelude to a wider epidemic in the community, but not in Australia , where successful preventive strategies have been applied. The weak link in these efforts has been in the prisons, which may become epidemic hotspot
Managing HIV. Part 8: Controlling an epidemic. 8.6 Epidemiological surveillance for HIV and AIDS.: Med J Aust. 1996 Sep 2;165(5):268-71. Unique Identifier : AIDSLINE MED/96413532; Kaldor JM; Crofts N; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW.; Epidemiological surveillance is an essential tool for planning health services and assessing the effectiveness of efforts to prevent and treat HIV infection.
Vancomycin-resistant Enterococcus faecium colonisations [letter]: Med J Aust. 1996 Sep 2;165(5):292-3. Unique Identifier : AIDSLINE MED/96413537; Ferguson J; Butt H; Johnson C; Boyle M
Neuroepidemiology of HIV infection.: Neurol Clin. 1996 May;14(2):359-82. Unique Identifier : AIDSLINE MED/96424716; Dal Pan GJ; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore,; Maryland, USA.; There are a variety of HIV-related neurologic complications that have numerous causes. HIV-related neurologic illnesses are specific to the stage of HIV infection, although the greatest burden of neurologic disease and the most disabling syndromes occur in the more advanced stages. As the number of HIV-infected person
Youth Risk Behavior Surveillance--United States, 1995.: MMWR CDC Surveill Summ. 1996 Sep 27;45(4):1-84. Unique Identifier : AIDSLINE MED/96438672; Kann L; Warren CW; Harris WA; Collins JL; Williams BI; Ross JG; Kolbe LJ; Division of Adolescent and School Health, National Center for; Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA; 30341-3724, USA.; PROBLEM/CONDITION: Priority health-risk behaviors that contribute to the leading causes of mortality, morbidity, and social problems among youth and adults often are established during youth, extend into adulthood, and are interrelated. REPORTING PERIOD: February through May 1995. DESCRIPTION OF THE SYSTEM: The Youth
[Differences in recognition of peptides of the MHC H-2Kb molecule between cytotoxic T-lymphocytes, memory cells, and T-suppressor cells, specific for alloantigen H-2Kb]: Mol Biol (Mosk). 1996 Jan-Feb;30(1):156-62. Unique Identifier : AIDSLINE MED/96319979; Brondz BD; Kazanskii DB; Chernysheva AD; Pavlova TN; Ivanov VS
[Interaction of primers with mutant forms of human immunodeficiency virus reverse transcriptase]: Mol Biol (Mosk). 1996 Jan-Feb;30(1):231-40. Unique Identifier : AIDSLINE MED/96319987; Zakharova OD; Suturina OA; Gudima SO; Pokholok DK; Iamkovoi VI; Kochetkov SN; Nevinskii GA
[Expression of the HIV-1 CD4 receptor gene in insect cells using a baculoviral system]: Mol Biol (Mosk). 1996 May-Jun;30(3):524-8. Unique Identifier : AIDSLINE MED/96320019; Belzhelarskaia SN; Sutugina LP; Tolkacheva TV; Rubtsov PM; Skriabin KG
[Identification and isolation of proteins, recognizing the sequence of the human immunodeficiency virus (HIV-1) enhancer]: Mol Biol (Mosk). 1996 May-Jun;30(3):714-20. Unique Identifier : AIDSLINE MED/96320039; Nikolaev LG
[Functional characteristics of liver T-lymphocytes in the allogenic response to mutant MHC class I and II molecules]: Mol Biol (Mosk). 1996 May-Jun;30(3):721-8. Unique Identifier : AIDSLINE MED/96320040; Chernysheva AD; Brondz BD; Anosova NG; Boiko RZ; Aizenberg LV; Kazanskii DB
A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. AIDS Clinical Trials Group Study 175 Study Team [see comments]: N Engl J Med. 1996 Oct 10;335(15):1081-90. Unique Identifier : AIDSLINE MED/96434823; Hammer SM; Katzenstein DA; Hughes MD; Gundacker H; Schooley RT; Haubrich RH; Henry WK; Lederman MM; Phair JP; Niu M; Hirsch MS; Merigan TC; Harvard Medical School, Boston, MA 02215, USA.; BACKGROUND: This double-blind study evaluated treatment with either a single nucleoside or two nucleosides in adults infected with human immunodeficiency virus type 1 (HIV-1) whose CD4 cell counts were from 200 to 500 per cubic millimeter. METHODS: We randomly assigned 2467 HIV-1--infected patients (43 percent without
The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team [see comments]: N Engl J Med. 1996 Oct 10;335(15):1091-8. Unique Identifier : AIDSLINE MED/96434824; Katzenstein DA; Hammer SM; Hughes MD; Gundacker H; Jackson JB; Fiscus S; Rasheed S; Elbeik T; Reichman R; Japour A; Merigan TC; Hirsch MS; Stanford University Medical Center, CA 94305, USA.; BACKGROUND: We studied measures of human immunodeficiency virus (HIV) replication, the viral phenotype, and immune function (CD4 cell counts) and the relation of changes in these indicators to clinical outcomes in a subgroup of patients in a controlled trial of early antiretroviral treatment for HIV, the AIDS Clinical
Zidovudine alone or in combination with didanosine or zalcitabine in HIV-infected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter. Investigators for the Terry Beirn Community Programs for Clinical Research on AIDS [see comments]: N Engl J Med. 1996 Oct 10;335(15):1099-106. Unique Identifier : AIDSLINE MED/96434825; Saravolatz LD; Winslow DL; Collins G; Hodges JS; Pettinelli C; Stein DS; Markowitz N; Reves R; Loveless MO; Crane L; Thompson M; Abrams D; St. John Hospital, Detroit, MI, USA.; BACKGROUND: We compared two combinations of nucleosides with zidovudine alone in patients with advanced human immunodeficiency virus (HIV) infection. METHODS: A total of 1102 patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter were randomly assigned to receive zidovudi
Images in clinical medicine. Syphilitic gummas in a patient with human immunodeficiency virus infection.: N Engl J Med. 1996 Oct 10;335(15):1123. Unique Identifier : AIDSLINE MED/96434828; Roeske LC; Kennedy PR; Emory University School of Medicine, Atlanta, GA 30322, USA.
Therapy for human immunodeficiency virus infection -- what have we learned? [editorial; comment]: N Engl J Med. 1996 Oct 10;335(15):1142-4. Unique Identifier : AIDSLINE MED/96434831; Corey L; Holmes KK
Occupational exposure to blood among medical students.: N Engl J Med. 1996 Oct 10;335(15):1150-3. Unique Identifier : AIDSLINE MED/96434834; Tereskerz PM; Pearson RD; Jagger J; University of Virginia Health Sciences Center, Charlottesville; 22908, USA.
Cerebral syphilitic gumma in an HIV-negative patient presenting as prolonged focal motor status epilepticus [letter]: N Engl J Med. 1996 Oct 10;335(15):1159-60. Unique Identifier : AIDSLINE MED/96434842; Suarez JI; Mlakar D; Snodgrass SM
Cryptococcosis as an opportunistic infection in immunodeficiency secondary to paracoccidioidomycosis.: Mycopathologia. 1996;133(2):65-9. Unique Identifier : AIDSLINE MED/96358229; Benard G; Gryschek RC; Duarte AJ; Shikanai-Yasuda MA; Immunogenetic and Experimental Transplantation Laboratory,; Faculty of Medicine, Universidade de Sao Paulo, Brazil.; We describe the case reports of two patients with immunodeficiency secondary to paracoccidioidomycosis (PCM) and opportunistic Cryptococcus neoformans infections. Secondary immunodeficiency likely occurred as a consequence of the intestinal loss of proteins and lymphocytes associated with malabsorption syndrome due to
Japan's HIV blood scandal broadens out [news]: Nature. 1996 Sep 26;383(6598):291. Unique Identifier : AIDSLINE MED/96404344; Swinbanks D
Plants and AIDS [letter]: Nature. 1996 Sep 26;383(6598):294. Unique Identifier : AIDSLINE MED/96404345; Atta-ur-Rahman
An RNA-export mediator with an essential nuclear export signal.: Nature. 1996 Sep 26;383(6598):357-60. Unique Identifier : AIDSLINE GENBANK/U68475; Murphy R; Wente SR; Department of Cell Biology and Physiology, Washington University; School of Medicine, St Louis, Missouri 63110, USA.; The Rev protein of human immunodeficiency virus type 1 (HIV-1) mediates the translocation of viral messenger RNAs from the nucleus to the cytoplasm. In yeast, Rev can mediate the nuclear export of Rev response-element-containing RNAs. The export of Rev itself proceeds through the nuclear pore complex and requires a nu
[Active euthanasia in the hospital: the role of the consultant psychiatrist]: Ned Tijdschr Geneeskd. 1996 Aug 24;140(34):1709-12. Unique Identifier : AIDSLINE MED/96384749; Hengeveld MW; Klijn FA; Casteelen G; Academisch Ziekenhuis, Psychiatrische Consultatieve Dienst,; Leiden.
Human immunodeficiency virus infection in patients on maintenance dialysis [letter]: Nephron. 1996;72(4):727. Unique Identifier : AIDSLINE MED/96284197; Lago M; Perez-Garcia R; Garcia de Vinuesa MS; Anaya F; Valderrabano F
Early diagnosis of tuberculous meningitis by polymerase chain reaction.: Neurology. 1995 Dec;45(12):2228-32. Unique Identifier : AIDSLINE MED/96109150; Kox LF; Kuijper S; Kolk AH; Department of Biomedical Research, Royal Tropical Institute,; Amsterdam, The Netherlands.; BACKGROUND: Rapid detection of Mycobacterium tuberculosis is of vital importance for patients with tuberculous meningitis. We evaluated an improved polymerase chain reaction (PCR) technique for rapid and specific identification of M tuberculosis in CSF. METHODS: The technique was used on CSF samples from 42 patients (
Hereditary adult-onset Alexander's disease with palatal myoclonus, spastic paraparesis, and cerebellar ataxia.: Neurology. 1995 Dec;45(12):2266-71. Unique Identifier : AIDSLINE MED/96109157; Schwankhaus JD; Parisi JE; Gulledge WR; Chin L; Currier RD; Veterans Administration Outpatient Clinic, Texas Tech University; Health Sciences Center, Lubbock, USA.; We describe a progressive neurologic disorder in three sisters characterized clinically by palatal myoclonus, spastic weakness, hyperreflexia, mild cerebellar dysfunction, and ocular motor abnormalities. Postmortem examination of one patient demonstrated widespread Rosenthal fiber deposition associated with demyelinat
Managing HIV infection: how to bolster your patient's fragile health.: Nursing. 1996 Aug;26(8):26-35; quiz 36-7. Unique Identifier : AIDSLINE MED/96403636; Kenny P
AIDS [news]: N Z Med J. 1996 Aug 23;109(1028):326. Unique Identifier : AIDSLINE MED/96413580
Teleconference on HIV and pregnancy set for June 18.: Pa Nurse. 1996 Apr;51(4):7. Unique Identifier : AIDSLINE MED/96364931
Virus-induced immunosuppression is linked to rapidly fatal disease in infant rhesus macaques infected with simian immunodeficiency virus.: Pediatr Res. 1996 Apr;39(4 Pt 1):630-5. Unique Identifier : AIDSLINE MED/96259174; Otsyula MG; Miller CJ; Marthas ML; Van Rompay KK; Collins JR; Pedersen NC; McChesney MB; School of Veterinary Medicine, University of California-Davis; 95616-8542, USA.; Six newborn rhesus macaques were experimentally infected with pathogenic Simian immunodeficiency virus of macaques (SIVmac251), and three newborn macaques were infected with avirulent SIVmac1A11. The former developed rapidly fatal simian AIDS and died within 26 wk of age, whereas the latter remained clinically normal.
Preparation of oligoribonucleotides containing 4-thiouridine using Fpmp chemistry. Photo-crosslinking to RNA binding proteins using 350 nm irradiation.: Nucleic Acids Res. 1996 Aug 15;24(16):3173-80. Unique Identifier : AIDSLINE MED/96371062; McGregor A; Rao MV; Duckworth G; Stockley PG; Connolly BA; Department of Biochemistry, The University of Newcastle,; Newcastle upon Tyne, UK.; The preparation of a 4-thiouridine phosphoramidite suitable for RNA synthesis and its subsequent incorporation into oligoribonucleotides is described. The thiol group is protected with a 2-cyanoethyl group and the 2 -OH with a 1-(2-fluorophenyl)-4-methoxypiperidin-4-yl function. Thiouridine-containing oligoribonucleot
The role of clarithromycin in the prophylaxis of disseminated Mycobacterium avium-intracellulare infection in patients with AIDS.: Pharmacotherapy. 1996 May-Jun;16(3):393-400. Unique Identifier : AIDSLINE MED/96336742; Mertl SL; Lyon Consulting Group, Inc., Marietta, Georgia 30068, USA.; Clarithromycin is a first-line agent in the treatment of disseminated disease due to Mycobacterium avium-intracellulare (dMAC) in patients with the acquired immunodeficiency syndrome, and its role in dMAC prophylaxis is nearing definition. Fifteen abstracts described clinical outcomes when clarithromycin was given in
The management of treatment-resistant depression in the medically ill.: Psychiatr Clin North Am. 1996 Jun;19(2):329-50. Unique Identifier : AIDSLINE MED/96424732; Franco-Bronson K; Department of Psychiatry and Psychology, Cleveland Clinic; Foundation, Ohio, USA.; There are a few well-designed studies to systematically assess treatment-resistant depression in the medically ill patient. Psychiatrists, however, do have extensive clinical experience in treating depression in the medical patient. This experience can be useful in helping to determine treatment resistance and in sele
Social support and barriers to family involvement in caregiving for persons with AIDS: implications for patient education.: Patient Educ Couns. 1996 Jan;27(1):85-94. Unique Identifier : AIDSLINE MED/96380739; Smith MY; Rapkin BD; Psychiatry Service, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021, USA.; If efforts to promote family involvement in patient education and other caregiving activities for people with AIDS (PWAs) are to be successful, clinicians need information concerning PWAs family network and the barriers PWAs face in obtaining support. Using data from interviews with 224 PWAs in New York City, we asse
Patients as teachers: an integrated approach to teaching medical students about the ambulatory care of HIV infected patients.: Patient Educ Couns. 1996 Jan;27(1):95-101. Unique Identifier : AIDSLINE MED/96380740; Vail R; Mahon-Salazar C; Morrison A; Kalet A; Gouverneur Hospital, Bellevue Hospital Center, New York, USA.; Our experience with medical students in a large inner city hospital left us concerned that students fears affect their ability to learn about and care for HIV-positive people. Therefore, we decided to create an environment in which the students could feel safe exploring their own attitudes and feelings about HIV. To
The specialist nurse in HIV/AIDS medicine.: Postgrad Med J. 1996 Apr;72(846):211-3. Unique Identifier : AIDSLINE MED/96297247; Whitehead CM; AIDS Clinical Group, Royal Liverpool University Hospital, UK.; The management of patients with human immunodeficiency virus infection requires a multidisciplinary holistic approach. Hospital-based specialist nurses can both co-ordinate and facilitate their hospital care, and also ensure early and effective discharge back into the community.
Thoracic spondylosis presenting with spastic paraparesis.: Postgrad Med J. 1996 Apr;72(846):243-4. Unique Identifier : AIDSLINE MED/96297259; Chana JS; Afshar F; Department of Neurosurgery, St Bartholomew's Hospital, London,; UK.; Spondylotic change of the spine is common in the cervical and lumbar regions and may present with compression of the spinal cord and nerve roots. Myelopathy due to degenerative disease in the thoracic spine is exceptional. Only a few cases have been reported in the literature and these reports have described disease i
Cortical blindness in a 35-year-old man.: Postgrad Med J. 1996 Apr;72(846):249-51. Unique Identifier : AIDSLINE MED/96297262; Rickards C; Shepherd DI; Department of Neurology, North Manchester General Hospital,; Crumpsall, UK.
Insulin resistance and development of diabetes mellitus associated with megestrol acetate therapy.: Postgrad Med J. 1996 Jun;72(848):365-7. Unique Identifier : AIDSLINE MED/96318931; Jain P; Girardi LS; Sherman L; Berelowicz M; Smith LG; Department of Internal Medicine, State University of New York,; Stony Brook, USA.; We describe a case of diabetes mellitus induced by megestrol acetate in a patient with the acquired immunodeficiency syndrome. Metabolic studies including an arginine infusion test excluded an insulinopenic state and suggested insulin resistance as the underlying mechanism for hyperglycaemia. Withdrawal of megestrol a
[Left vocal cord paralysis in cytomegalovirus multifocal neuropathy in a patient with HIV infection]: Presse Med. 1996 Jan 27;25(3):106-7. Unique Identifier : AIDSLINE MED/96342811; de La Blanchardiere A; Dore M; Salmon D; Sicard D; Service de Medicine interne 2, Hopital Cochin, Paris.; Cytomegalovirus multifocal neuropathies (CMV-MN) in patients with AIDS are much less frequent than meningoradiculitis. We report here the case of a patient with AIDS hospitalized because of severe motor weakness and paralyzed left true vocal cord (PVC), related to a multifocal neuropathy. CSF analysis was normal with
[Transmission of human immunodeficiency virus to the fetus during pregnancy]: Presse Med. 1996 Jan 27;25(3):119-25. Unique Identifier : AIDSLINE MED/96342814; d'Ercole C; Cravello L; Sperandeo D; Bretelle F; Piechon L; Boubli L; Blanc B; Service de Gynecologie-Obstetrique B, Hopital de la Conception,; Marseille.; Estimates of the rate of human immunodeficiency virus vertical transmission range from 15% to 40%, and the rate is lower in European and American studies than in African studies. There appears to be a relationship between maternal factors, mode of delivery and mother-to-child transmission. The risk factors or markers
[Reactivation of hepatitis B in AIDS (letter)]: Presse Med. 1996 Jan 27;25(3):128. Unique Identifier : AIDSLINE MED/96342820; Berthelot P; Clement MA; Fresard A; Lucht F
[Parvovirus B19 infection. New physiopathological approaches]: Presse Med. 1996 Feb 3;25(4):162-6. Unique Identifier : AIDSLINE MED/96306558; Labau E; Bonnet E; Alric L; Massip P; Service de Pathologie infectieuse, CHU Rangueil, Toulouse.; Knowledge of the pathophysiological mechanisms governing Parvovirus B19 infection has been modified with the recent discovery of its cellular receptor. The cell lines susceptible to infection can be identified on the basis of the nature and distribution of the virus in the human organism. The Parvovirus B19 can underg
Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9571-6. Unique Identifier : AIDSLINE MED/96382507; Strack PR; Frey MW; Rizzo CJ; Cordova B; George HJ; Meade R; Ho SP; Corman J; Tritch R; Korant BD; Molecular Biology Department, DuPont Merck Pharmaceutical; Company, Wilmington, De 19880-0336, USA.; Expression of the human immunodeficiency virus type 1 (HIV) protease in cultured cells leads to apoptosis, preceded by cleavage of bcl-2, a key negative regulator of cell death. In contrast, a high level of bcl-2 protects cells in vitro and in vivo from the viral protease and prevents cell death following HIV infectio
Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9606-11. Unique Identifier : AIDSLINE MED/96382513; Li Y; Bergeron JJ; Luo L; Ou WJ; Thomas DY; Kang CY; Department of Zoology, Faculty of Science, University of Western; Ontario, London, Canada.; The HIV-1 envelope glycoprotein gp120 displays inefficient intracellular transport, which is caused by its retention in the endoplasmic reticulum. Coexpression in insect cells (Sf9) of HIV-1 gp120 with calnexin has shown that their interaction was modulated by the signal sequence of HIV-1 gp120. gp120, with its natura
CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9699-703. Unique Identifier : AIDSLINE MED/96382530; Lee SY; Lee SY; Kandala G; Liou ML; Liou HC; Choi Y; Howard Hughes Medical Institute, Rockefeller University, New; York, NY 10021, USA.; CD30 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD30 is expressed on normal activated lymphocytes, on several virally transformed T- or B-cell lines and on neoplastic cells of Hodgkin s lymphoma. The interaction of CD30 with its ligand induces pleiotropic effects on cells resulting in prolife
Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9736-41. Unique Identifier : AIDSLINE MED/96382536; Madrenas J; Schwartz RH; Germain RN; Lymphocyte Biology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1892, USA.; Full activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell. TCR recognition of agonist ligands in the absence of accessory signals frequently results in the induction of a state of unresponsiveness ter
Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9742-7. Unique Identifier : AIDSLINE MED/96382537; Farnet CM; Wang B; Lipford JR; Bushman FD; Infectious Disease Laboratory, Salk Institute for Biological; Studies, La Jolla, CA 92037, USA.; To replicate, HIV-1 must integrate a cDNA copy of the viral RNA genome into a chromosome of the host. The integration system is a promising target for antiretroviral agents, but to date no clinically useful integration inhibitors have been identified. Previous screens for integrase inhibitors have assayed inhibition o
A candidate live inactivatable attenuated vaccine for AIDS.: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9810-5. Unique Identifier : AIDSLINE MED/96382549; Chakrabarti BK; Maitra RK; Ma XZ; Kestler HW; Department of Molecular Biology, Cleveland Clinic Foundation, OH; 44195, USA.; The recent discovery of long term AIDS nonprogressors who harbor nef-attenuated HIV suggests that a naturally occurring live vaccine for AIDS may already exist. Animal models have shown that a live vaccine for AIDS, attenuated in nef, is the best candidate vaccine. There are considerable risks, real and perceived, wit
Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis.: Respir Med. 1996 Feb;90(2):79-85. Unique Identifier : AIDSLINE MED/96297042; Mueller R; Chanez P; Campbell AM; Bousquet J; Heusser C; Bullock GR; Pharma Research, Ciba-Geigy AG, Basel, Switzerland.; Bronchial biopsies have made possible the detailed study of the pathology of the airways of humans with respiratory disease. Much data has been accumulated on asthmatics or normal controls but much less is known about chronic bronchitics. The aim of this study was to characterize the cellular and cytokine pattern seen
Severe pulmonary infections in AIDS patients.: Semin Respir Infect. 1996 Jun;11(2):119-28. Unique Identifier : AIDSLINE MED/96373042; Gatell JM; Marrades R; el-Ebiary M; Torres A; Infectious Disease Unit, Universitat de Barcelona, Spain.; Pulmonary infections are a very common complication in acquired immune deficiency syndrome (AIDS) patients. These infections may be severe enough to initiate the admission of these patients to intensive care units (ICU). Pneumocystis carinii pneumonia (PCP) is the most frequent cause of ICU admission because of acute
[Multiple digestive involvement in visceral leishmaniasis in a patient with HIV infection: favourable course with itraconazole]: Rev Med Interne. 1996;17(3):234-7. Unique Identifier : AIDSLINE MED/96319092; Bechade D; Seurat L; Discamps G; Taniere PH; Du Bourguet F; Service de medecine interne et d'hematologie, HIA Robert; Picque, Bordeaux-Armees, France.; We report a case of visceral leishmaniasis due to Leishmania infantum in a 35 year-old patient with acquired immunodeficiency syndrome who complained of chronic diarrhea. Biopsy specimens of gastric and duodenal mucosa and bone marrow aspirate led to the diagnosis. Enterocytozoon bieneusi, fortuitously found in the du
[Thrombotic microangiopathies in HIV infection: 4 cases]: Rev Med Interne. 1996;17(3):238-42. Unique Identifier : AIDSLINE MED/96319093; Ninin E; Merrien D; Hamidou M; Testa A; Milpied B; Raffi F; Service de medecine interne, Hotel-Dieu, Nantes, France.; Thrombotic microangiopathy (TMA) has been rarely described in HIV-infected patients. We report four cases of TMA during HIV infection and we analyse clinical, biological, etiologic, therapeutic and evolutive aspects of these four cases. Initial symptomatology is non specific and diagnosis is often delayed. Peripheric
Papillomavirus in cervicovaginal smears of women infected with human immunodeficiency virus.: Rev Paul Med. 1995 Nov-Dec;113(6):1009-11. Unique Identifier : AIDSLINE MED/96340568; Eduardo Calore E; Jose Cavaliere M; Kasumi Shirata N; Araujo MF; Secao de Anatomia Patologica, Instituto de Infectologia; Emilio Ribas, Sao Paulo/SP-Brasil.; It has been described that women infected with the human immunodeficiency virus (HIV) present more frequent cytological abnormalities in cervicovaginal smears, generally related to infection by human papillomavirus (HPV). The present work is a study of cervicovaginal smears of 147 HIV-seropositive women submitted to r
Regulatory issues of importance to developing anti-HIV therapeutics.: Toxicol Pathol. 1996 May-Jun;24(3):278-80. Unique Identifier : AIDSLINE MED/96338971; Hastings KL; Division of Antiviral Drug Products, Center for Drug Evaluation; and Research, United States Food and Drug Administration,; Rockville, Maryland 20857, USA.; In the United States , before clinical trials with new drugs can proceed, an Investigational New Drug (IND) application must be submitted to the Food and Drug Administration. Applications for drugs intended for the treatment of HIV-related diseases are reviewed by the Division of Anti-V
HIV report. Always a death sentence?: RN. 1996 Aug;59(8):22-7; quiz 28. Unique Identifier : AIDSLINE MED/96403621; Cerrato PL
HIV report. Meeting psychosocial needs.: RN. 1996 Aug;59(8):23-7; quiz 28. Unique Identifier : AIDSLINE MED/96403622; Gray J
Women with HIV pain are often undertreated.: RN. 1996 Aug;59(8):65. Unique Identifier : AIDSLINE MED/96403629; Scholz MJ
Phenotypic analysis of antigen-specific T lymphocytes.: Science. 1996 Oct 4;274(5284):94-6. Unique Identifier : AIDSLINE MED/96412252; Altman JD; Moss PAH; Goulder PJR; Barouch DH; McHeyzer-Williams MG; Bell JI; McMichael AJ; Davis MM; Department of Microbiology and Immunology, Stanford University; School of Medicine, Stanford, CA 94305-5428, USA.; Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers. Tetramers o
Disseminated Mycobacterium avium complex presenting with osteomyelitis of the distal femur and proximal tibia.: Skeletal Radiol. 1996 Feb;25(2):193-6. Unique Identifier : AIDSLINE MED/96237390; Weingardt JP; Kilcoyne RF; Russ PD; Johnston RJ; Nawaz S; Department of Radiology, University of Colorado Health Sciences; Center, Denver 80262, USA.
Depressive symptoms over the course of HIV infection before AIDS.: Soc Psychiatry Psychiatr Epidemiol. 1996 Jun;31(3-4):212-9. Unique Identifier : AIDSLINE MED/96349901; Lyketsos CG; Hoover DR; Guccione M; Dew MA; Wesch J; Bing EG; Treisman GJ; Department of Psychiatry, School of Medicine, Johns Hopkins; University, Baltimore, MD 21287-5371, USA.; The objective of this study was to describe the prevalence and course of depressive symptoms before AIDS in HIV-infected homosexual men. A descriptive and comparative analysis of data from HIV-infected and -uninfected homosexual men in the Multicenter AIDS Cohort Study was performed. The Center for Epidemiologic Studi
Insurance for HIV sufferers [news]: S Afr Med J. 1996 Jun;86(6):630. Unique Identifier : AIDSLINE MED/96291359
Legal issues for nurses. Minors and the ability to consent to HIV testing.: Tex Nurs. 1996 Apr;70(4):12-3. Unique Identifier : AIDSLINE MED/96365102; Richardson JI
Clotting factor concentrated--whither purity? [letter]: Thromb Haemost. 1995 Dec;74(6):1604-6. Unique Identifier : AIDSLINE MED/96368091; Thomas DP
Epidemiology of classic Kaposi's sarcoma, with special reference to mediterranean population.: Tumori. 1995 Sep-Oct;81(5):308-14. Unique Identifier : AIDSLINE MED/96397551; Franceschi S; Geddes M; Servizio di Epidemiologia, Centro di Riferimento Oncologico,; Aviano (PN), Italy.; An excess of classic Kaposi s sarcoma (KS) in individuals of southern European ancestry has long been suspected and recently quantified in terms of age-standardized rates. In Italy and most notably in southern Italy for the period 1976-84, prior to the AIDS epidemic, KS incidence ra
The relevance of VDJ PCR protocols in detecting B-cell clonal expansion in lymphomas and other lymphoproliferative disorders.: Tumori. 1995 Nov-Dec;81(6):405-9. Unique Identifier : AIDSLINE MED/96397570; De Re V; De Vita S; Carbone A; Ferraccioli G; Gloghini A; Marzotto A; Pivetta B; Dolcetti R; Boiocchi M; Division of Experimental Oncology I, Centro di Riferimento; Oncologico, Aviano, Italy.; AIMS AND BACKGROUND: The detection of immunoglobulin heavy chain variable (VH)-diversity (DH)-joining (JH) region gene rearrangement by polymerase chain reaction (VDJ PCR) has been recently proposed as a rapid approach to assess B-cell clonality in lymphoproliferative disorders. The aim of the present study was to det
Ocular manifestations of HIV infection.: Trans Am Ophthalmol Soc. 1995;93:623-83. Unique Identifier : AIDSLINE MED/96358725; Jabs DA; Department of Ophthalmology, Johns Hopkins University School of; Medicine, USA.; OBJECTIVE: To evaluate the frequency of ocular complications and the clinical outcomes of these complications in patients with various stages of HIV infection. METHODS: Retrospective review of all HIV-infected patients seen in an AIDS ophthalmology clinic from November 1983 through December 31, 1992. RESULTS: Eleven-h
Functionality of chimeric Rev proteins of HIV/SIV.: Virus Genes. 1995;11(1):11-14. Unique Identifier : AIDSLINE MED/96404051; Furuta RA; Sakai H; Kawamura M; Tokunaga K; Hatanaka M; Adachi A; Department of Viral Oncology, Kyoto University, Japan.; Studies on functional compatibility of various Rev proteins derived from all known human and simian immunodeficiency virus subgroups have shown that this essential gene product is not always exchangeable among the viruses. In an attempt to map the region of Rev proteins responsible for the observed nonreciprocal compl
Functional analysis of human spuma retrovirus genome.: Virus Genes. 1995;11(1):15-20. Unique Identifier : AIDSLINE MED/96404052; Adachi A; Sakai H; Tokunaga K; Kawamura M; Department of Viral Oncology, Kyoto University, Japan.; Human spuma retrovirus (HSRV) belongs to retroviruses that possess a complex genome organization. HSRV carries at least three extra genes in the region between env and the 3 long terminal repeat, which are not found in simple retroviruses. Via alternative splicing, these HSRV genes can encode several proteins. To gen
Detection of contamination of vaccines with the reticuloendotheliosis virus by reverse transcriptase polymerase chain reaction (RT-PCR).: Virus Res. 1996 Feb;40(2):113-21. Unique Identifier : AIDSLINE MED/96290237; Takagi M; Ishikawa K; Nagai H; Sasaki T; Gotoh K; Koyama H; National Veterinary Assay Laboratory, Tokyo, Japan.; The reverse transcriptase polymerase chain reaction (RT-PCR) was applied to detect contamination of Marek s disease (MD) vaccine with reticuloendotheliosis virus (REV). The env primers were used for the 1st RT-PCR to amplify the DNA fragments of REV-A and -T. The rel and env primers were used for nested-PCR to confirm
Diagnostic value of stereotactic biopsy of cerebral lesions in patients with AIDS.: Acta Neurochir (Wien). 1995;134(3-4):214-9. Unique Identifier : AIDSLINE MED/96342582; Alesch F; Armbruster C; Budka H; Neurochirurgische Universitatsklinik Wien, Vienna, Austria.; A neurological complication occurs in 40-60% of HIV infected patients during the course of the disease. In 10-20% the neurological complication is the first manifestation of the HIV infection. A reliable neuropathological diagnosis is a prerequisite for a specifically selected treatment. While modern computer-assisted
False-negative single-photon emission CT in AIDS lymphoma: lack of effect of steroids [letter]: AJNR Am J Neuroradiol. 1996 May;17(5):1000-2. Unique Identifier : AIDSLINE MED/96316065; Campbell BG; Hurley J; Zimmerman RD
Deep gray matter structures in HIV infection: a proton MR spectroscopic study.: AJNR Am J Neuroradiol. 1996 May;17(5):973-8. Unique Identifier : AIDSLINE MED/96316061; Meyerhoff DJ; Weiner MW; Fein G; Department of Radiology, University of California, San Francisco,; USA.; PURPOSE: To evaluate the effects of human immunodeficiency virus (HIV) infection on proton metabolites in brain regions carrying the heaviest HIV load. METHODS: We used two-dimensional proton MR spectroscopy with a preselected volume at the level of the third ventricle to measure N-acetyl-aspartate (NAA) and metabolit
Soluble interleukin 2 receptors in patients with Bell's palsy.: Allergol Immunopathol (Madr). 1996 May-Jun;24(3):112-5. Unique Identifier : AIDSLINE MED/96344005; Bujia J; Kim C; Bruegel F; Department of Othorhinolaryngology, Ludwig Maximilians University; of Munich.; The etiology and pathogenesis of Bell s palsy are still an enigma. Some studies have reported about the presence of cellular and humoral immune dysfunction in this disease. Recently, determination of soluble interleukin 2 receptor has proven to be a valuable clinical tool to detect dysregulation of T lymphocyte functi
The role of the family physician in the day care setting.: Am Fam Physician. 1996 Sep 15;54(4):1257-65, 1267-8. Unique Identifier : AIDSLINE MED/96413410; Olsen CG; Wong CP; Gordon RE; Harper DJ; Whitecar PS; Wright State University School of Medicine, Dept. of Family; Medicine, Dayton, OH 45408, USA.; Injuries and infectious respiratory, gastrointestinal and dermatologic diseases are common in day care settings. Most day care injuries are contusions, abrasions and cuts involving the head and extremities. Impact-absorbing surfaces under playground equipment, safely-proofing of all play areas, increased staff supervi
Improving HIV/AIDS prevention in prisons is good public health policy [editorial; comment]: Am J Public Health. 1996 Sep;86(9):1201-3. Unique Identifier : AIDSLINE MED/96399990; Gaiter J; Doll LS
New York inmates' HIV risk behaviors: the implications for prevention policy and programs [see comments]: Am J Public Health. 1996 Sep;86(9):1211-5. Unique Identifier : AIDSLINE MED/96399994; Mahon N; Osborne Associations, New York, NY, USA.; OBJECTIVES: The median incidence rate of acquired immunodeficiency syndrome (AIDS) among prisoners is 7 times higher than for the general population. Yet high-risk sexual activity and drug use in US correctional facilities remain unexamined. This study explores inmate perceptions of high-risk behavior in New York stat
Tuberculosis and HIV among mentally ill men in a New York City shelter [letter]: Am J Public Health. 1996 Sep;86(9):1318-9. Unique Identifier : AIDSLINE MED/96400012; Saez H; Valencia E; Conover S; Susser E
Needle exchange programs: New Zealand's experience [letter]: Am J Public Health. 1996 Sep;86(9):1319. Unique Identifier : AIDSLINE MED/96400013; Lichtenstein B
Assay of ribozyme-substrate cleavage by anion-exchange high-performance liquid chromatography.: Anal Biochem. 1995 Dec 10;232(2):204-9. Unique Identifier : AIDSLINE MED/96359711; Vinayak R; Andrus A; Sinha ND; Hampel A; Department of Biological Sciences, Northern Illinois University,; DeKalb 60115, USA.; An HPLC procedure has been developed that can be used to monitor the rate of phosphodiester cleavage of an oligoribonucleotide substrate by an RNA ribozyme with catalytic activity. The method operates at high substrate concentrations (far beyond K(m)), thus allowing the reactions to approach Vmax of the reaction. This
Use of a polyethylene glycol-peptide conjugate in a competition gel shift assay for screening potential antagonists of HIV-1 Tat protein binding to TAR RNA.: Anal Biochem. 1995 Dec 10;232(2):238-42. Unique Identifier : AIDSLINE MED/96359716; Wang J; Huang SY; Choudhury I; Leibowitz MJ; Stein S; Center for Advanced Biotechnology and Medicine, Rutgers; University, Piscataway, New Jersey, USA.; Interference of binding of Tat protein to TAR RNA in HIV-1-infected cells may be a useful therapeutic strategy for AIDS. An electrophoretic assay to screen potential low-molecular-weight (
Prediction of human immunodeficiency virus protease cleavage sites in proteins.: Anal Biochem. 1996 Jan 1;233(1):1-14. Unique Identifier : AIDSLINE MED/96381128; Chou KC; Computer-Aided Drug Discovery, Pharmacia & Upjohn Laboratories,; Kalamazoo, Michigan 49007-4940, USA.; Knowledge of the polyprotein cleavage sites by HIV protease will refine our understanding of its specificity and the information thus acquired is useful for designing specific and efficient HIV protease inhibitors . The pace in searching for the proper inhibitors of
Raman spectroscopic determination of thymidine nucleoside structures in nucleotides.: Analyst. 1996 Feb;121(2):105-9. Unique Identifier : AIDSLINE MED/96274832; Escobar R; Carmona P; Molina M; Departamento de Quimica Analitica, Universidad de Sevilla,; Spain.; Several spectral differences in Raman spectra were observed for thymidine (TM), 3 -O-acetylthymidine (3 OATM), 3 ,5 -di-O-acetylthymidine (3 5 DOATM), thymidine 5 -monophosphoric acid (H2TMP) and its Ca2+, Sr2+ and Ba2+ salts owing to nucleoside conformational differences in the thymidine moiety. The spectroscopic cha
Viral status and antibody response in cattle inoculated with recombinant bovine leukemia virus-vaccinia virus vaccines after challenge exposure with bovine leukemia virus-infected lymphocytes.: Am J Vet Res. 1996 Jun;57(6):812-8. Unique Identifier : AIDSLINE MED/96348633; Cherney TM; Schultz RD; Department of Pathobiological Sciences, School of Veterinary; Medicine, University of Wisconsin, Madison 53706, USA.; OBJECTIVE: To determine the bovine leukemia virus (BLV) antibody response and infectivity status in BLV-vaccinated cattle after challenge exposure with BLV-infected lymphocytes. DESIGN: Steers were inoculated with vaccinia virus constructs expressing the gag, pol, and env genes of the BLV or the env gene only of the B
[Responses to triple viral and tetanus vaccination in HIV-infected children]: An Esp Pediatr. 1996 Apr;44(4):317-20. Unique Identifier : AIDSLINE MED/96389724; Echeverria Lecuona J; Aldamiz-Echevarria Azuara L; Cilla Eguiluz G; Perez Trallero E; Servicio de Pediatria, Hospital Aranzazu, San Sebastian.; Our objective was to study the antibody response to the parotiditis, rubella, measles and tetanus vaccines in HIV infected children. Forty-four children of HIV positive mothers, of which 14 were infected (SG) and 33 HIV negative (CG) were studied when they were between 2 and 3 years of age. Their response to vaccinati
[A comparative study of technics for the diagnosis of the human immunodeficiency virus in infants under 15 months by: viral cultivation, the polymerase chain reaction and antigen p24]: An Esp Pediatr. 1996 Jun;44(6):540-4. Unique Identifier : AIDSLINE MED/96389786; Munoz Fernandez MA; Obregon Gonzalez E; Navarro Caspistegui J; Gurbindo Gutierrez MD; Hernandez Sampelayo T; Fernandez-Cruz E; Servicio de Inmunologia, Hospital General Universitario Gregorio; Maranon, Madrid.; The objective of this study was to compare the polymerase chain reaction (PCR), virus culture (VC) and antigen detection (AG), assays which can be used for the early diagnosis of vertically transmitted HIV-1 infection in infants under 15 months of age, when a diagnosis cannot be based on seropositivity because of mate
[An interview with Rene Hivon. What will happen tomorrow in medical education? (interview)]: Ann Med Interne (Paris). 1996;147(1):31-4. Unique Identifier : AIDSLINE MED/96307209; Jouquan J
[Polyarthritis and neutropenia associated with activated clone T CD8 proliferation without large granulous lymphocytes: a new entity different from Felty's syndrome? (letter)]: Ann Med Interne (Paris). 1996;147(1):61-2. Unique Identifier : AIDSLINE MED/96307213; Amiot F; Macintyre E; Valensi F; Perichon I; Valcke JC; Hermine O
[Hemophagocytic syndromes. A series of 23 cases]: Ann Med Interne (Paris). 1996;147(3):138-44. Unique Identifier : AIDSLINE MED/96388689; Tiab M; Mechinaud F; Hamidou M; Gaillard F; Raffi F; Harousseau JL; Service d'Hematologie Clinique, Hotel-Dieu, Nantes.; Inappropriate macrophage activation is responsible for clinical, biological and histological features characterized by diffuse non malignant histiocytic tissue infiltration called reactive hemophagocytic syndrome (RHS). We report here 23 new cases. Immunodepression (10 cases), hematologic malignancies (13 cases) and
Prevalence of sexually transmitted diseases among commercial sex workers in Singapore from 1977 to 1993: the effects of screening measures.: Ann Acad Med Singapore. 1995 Jul;24(4):500-4. Unique Identifier : AIDSLINE MED/96113230; Goh CL; Chan RK; National Skin Centre, Singapore.; This paper discusses the trend of sexually transmitted diseases (STDs) among commercial sex workers in Singapore . Various STD control measures were introduced in Singapore since 1976 to control STDs among commercial sex workers. Under a Medical Surveillance Scheme introduced in
Prevalence of skin disease in patients infected with human immunodeficiency virus in Bangkok, Thailand.: Ann Acad Med Singapore. 1995 Jul;24(4):528-33. Unique Identifier : AIDSLINE MED/96113236; Sivayathorn A; Srihra B; Leesanguankul W; Department of Dermatology, Faculty of Medicine Siriraj Hospital,; Mahidol University, Bangkok, Thailand.; A detailed study of the skin lesions of 248 patients infected with the human immunodeficiency virus (HIV) in Bangkok, Thailand , is reported. The study population consisted of 140 patients with asymptomatic disease (stage I), 27 patients with symptomatic disease (stage II), and 81
Human immunodeficiency virus (HIV) antigen testing to detect HIV infection in female sex workers in Singapore.: Ann Acad Med Singapore. 1995 Jul;24(4):534-6. Unique Identifier : AIDSLINE MED/96113237; Chan RK; Ali K; Thoe SY; Department of STD Control, Singapore.; Human immunodeficiency virus (HIV) infection is characterised by seroconversion after a :window: period of 2 to 3 months. After this period antibodies are usually detectable by screening tests (enzyme immunoassay or particle agglutination) confirmed by Western blot analysis. We studied 1000 newly enrolled female sex w
Correlation between saliva and serum for human immunodeficiency virus 1 and 2 antibodies using a rapid test system.: Ann Acad Med Singapore. 1995 Jul;24(4):537-40. Unique Identifier : AIDSLINE MED/96113238; Leow YH; Goh A; Lim PY; Chan RK; Goh CL; Kamarudin BA; National Skin Centre, Singapore.; Currently, human immunodeficiency virus (HIV) tests are almost totally serum based. In situations where blood is difficult or inconvenient to obtain, a substitute to venepuncture offers an attractive alternative. The prototype OraScreen saliva dipsticks were tested on 278 samples comprising 100 normals, 100 samples fr
Project youth inform--a school-based sexually transmitted disease/acquired immune deficiency syndrome education programme.: Ann Acad Med Singapore. 1995 Jul;24(4):541-6. Unique Identifier : AIDSLINE MED/96113239; Soon T; Chan RK; Goh CL; Department of STD Control, National Skin Centre, Singapore.; A pilot project, :Youth Inform: endorsed by the Ministry of Health and Ministry of Education, Singapore , was undertaken in 1992 for 2 years. It aims to enhance sexually transmitted disease (STDs)/human immunodeficiency virus (HIV) control in Singapore by providing structured inf
Sexually transmitted diseases in Australia: a decade of change. Epidemiology and surveillance.: Ann Acad Med Singapore. 1995 Jul;24(4):569-78. Unique Identifier : AIDSLINE MED/96113245; Mulhall BP; Hart G; Harcourt C; Academic Unit of Sexual Health Medicine, Sydney Hospital, NSW,; Australia.; Survival data in the last decade for sexually transmitted diseases (STDs) other than human immunodeficiency virus (HIV) are uneven across the states/territories. The incidence of gonorrhoea decreased by more than 80%, but at different times in different patient groups, different states, and different anatomical sites.
Antimicrobial therapy of non-viral sexually transmitted diseases--an update.: Ann Acad Med Singapore. 1995 Jul;24(4):579-83. Unique Identifier : AIDSLINE MED/96113246; Chan RK; Department of STD Control, Singapore.; Azithromycin is an azalide antibiotic with important properties which allow it to be used as a single-dose treatment for genital Chlamydia trachomatic infections. A single 1 g dose is as effective as a standard seven-day course of doxycycline. Ofloxacin 400 mg bid for seven days is also effective against Chlamydia tra
Behavioural interventions in the control of human immunodeficiency virus and other sexually transmitted diseases--a review.: Ann Acad Med Singapore. 1995 Jul;24(4):602-7. Unique Identifier : AIDSLINE MED/96113250; Wong ML; Department of Community, Occupational and Family Medicine,; National University of Singapore, Singapore.; In the absence of an effective cure or vaccine, acquired immune deficiency syndrome (AIDS) preventive measures have focused on education and information to prevent and reduce high risk behaviours associated with AIDS/human immunodeficiency virus (HIV) transmission. Strategies to change behaviour can be divided into 4
Barriers to conception and disease.: Ann Acad Med Singapore. 1995 Jul;24(4):608-14. Unique Identifier : AIDSLINE MED/96113251; Donovan B; Sydney Sexual Health Centre, Sydney Hospital, NSW, Australia.; For the purpose of this review, :barriers: are defined as any method used during or after intercourse that physically or chemically isolates semen. Latex condoms for men are the best studied physical barrier and offer high efficacy as both a contraceptive and as protection against several major sexually transmissable
Selection and characterization of a mutant of feline immunodeficiency virus resistant to 2',3'-dideoxycytidine.: Antimicrob Agents Chemother. 1996 Apr;40(4):953-7. Unique Identifier : AIDSLINE MED/96254566; Medlin HK; Zhu YQ; Remington KM; Phillips TR; North TW; Division of Biological Sciences, University of Montana, Missoula; 59812, USA.; We have selected and plaque purified a mutant of feline immunodeficiency virus (FIV) that is resistant to 2 ,3 -dideoxycytidine ( ddC ). This mutant was selected in cultured cells in the continuous presence of 25 microM ddC. The mutant, designated DCR-5
Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia.: Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. Unique Identifier : AIDSLINE MED/96254568; Hughes WT; Killmar J; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105, USA.; A remarkably high rate of adverse events is associated with the use of trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus type 1 infection. We examined the efficacies of sulfonamides alone in the prevention of Pneumocystis carinii pneumonitis, with the assumption that at least some of the adve
Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.: Antimicrob Agents Chemother. 1996 Apr;40(4):973-8. Unique Identifier : AIDSLINE MED/96254570; Merali S; Clarkson AB Jr; Department of Medical and Molecular Parasitology, New York; University School of Medicine, New York 10016, USA.; Difluoromethylornithine (DFMO; eflornithine hydrochloride [Ornidyl]), a suicide inhibitor of the key polyamine biosynthesis enzyme ornithine decarboxylase (ODC), is effective in treating Pneumocystis carinii pneumonia, a common opportunistic infection associated with AIDS. Despite DFMO s specificity for ODC, the reaso
When is HIV an issue after child sexual abuse?: Arch Dis Child. 1996 Jul;75(1):85-7. Unique Identifier : AIDSLINE MED/96408895; Mok JY; Edinburgh Sick Children's NHS Trust, Department of Community; Child Health, Edinburgh.
Thalidomide treatment of mucosal ulcerations in HIV infection [letter]: Arch Dis Child. 1996 Jul;75(1):90. Unique Identifier : AIDSLINE MED/96408904; Harry TC
[Immunology of human Plasmodium falciparum malaria]: Ann Soc Belg Med Trop. 1995 Sep;75(3):159-78. Unique Identifier : AIDSLINE MED/96109965; Vanham G; Bisalinkumi E; Laboratoire d'Immunologie, Institut de Medecine Tropicale,; Antwerpen, Belgique.; The various stages of Plasmodium falciparum (sporozoites and liver stages, asexual blood stages and gametocytes) each interact in a particular way with the human immune system. Specific immunity against the liver stages is achieved through a coordinated action of CD8 T cells and specific antibodies, the latter in coll
B cells and T-lymphocyte subsets of the head-associated lymphoid tissues of the chicken.: Avian Dis. 1995 Oct-Dec;39(4):736-42. Unique Identifier : AIDSLINE MED/96362014; Maslak DM; Reynolds DL; Department of Microbiology, Immunology, and Preventive Medicine,; Iowa State University, Ames 50011, USA.; The head-associated lymphoid tissues of the chicken, composed of the harderian gland and the conjunctiva-associated lymphoid tissue (CALT), were studied to determine whether changes occurred in lymphocyte subpopulations as chickens age from 1 week to 8 weeks. The B cells and subpopulations of T-lymphocytes of the head
HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3).: Biochem Biophys Res Commun. 1996 Aug 23;225(3):839-43. Unique Identifier : AIDSLINE MED/96374408; Arion D; Harada R; Li X; Wainberg MA; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis,; Jewish General Hospital, Montreal, Quebec, Canada.; The transcription initiation primer for HIV-1 is a specific cellular tRNA species, tRNA(Lys3). We used several methods to assess the binding of tRNA by recombinant HIV-1 p51/p66 reverse transcriptase (RT), gel retardation analysis, intrinsic RT protein fluorescence quenching, and nitrocellulose filter binding assays.
Inhibition of HIV-1 Tat-mediated transactivation by quinacrine and chloroquine.: Biochem Biophys Res Commun. 1996 Sep 4;226(1):1-7. Unique Identifier : AIDSLINE MED/96400207; Jiang MC; Lin JK; Chen SS; Institute of Biochemistry, School of Medicine, National Taiwan; University, Taipei, Republic of China.; The replication of human immunodeficiency virus type 1 (HIV-1) requires cellular components to interact with regulatory elements located in the long terminal repeat (LTR) as well as viral proteins Tat and Rev. Several well known signaling transduction inhibitors were tested to determine their effects on the Tat-mediat
Identification of a new member of the MNP transcription factor family in differentiated HL60 cells.: Biochem Biophys Res Commun. 1996 Sep 13;226(2):488-94. Unique Identifier : AIDSLINE MED/96400285; Xu M; Sharma V; Bryans M; Wilkie NM; Department of Veterinary Bioscience, Ohio State University,; Columbus 43210, USA.; MIP-1 alpha is a secreted chemokine which can inhibit hematopoietic stem cells and modulate inflammatory responses. It is also an inhibitor of HIV replication in CD8+ T-cells, MIP-1 alpha is expressed in transformed B cells and can also be induced during cellular activation of CD4+ T-cells and monocytes. We have previ
Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases.: Biochem Biophys Res Commun. 1996 Sep 13;226(2):547-54. Unique Identifier : AIDSLINE MED/96400295; Meggio F; D'Agostino DM; Ciminale V; Chieco-Bianchi L; Pinna LA; Dipartimento di Chimica Biologica, Universita di Padova, Italy.; HIV-1 Rev transactivator is readily phosphorylated at separate regions by protein kinase CK2 and MAP kinase. Protein kinase CK1 cannot replace CK2 as phosphorylating agent and cdc2 only slowly phosphorylates Rev at one of the two sites affected by MAP kinase. Mutational analysis shows that Ser-8 and, to a lesser exten
Azidothymidine induces apoptosis in mouse myeloma cell line Sp2/0.: Biochem Pharmacol. 1996 Sep 27;52(6):857-62. Unique Identifier : AIDSLINE MED/96375133; Sailaja G; Nayak R; Antony A; Department of Microbiology and Cell Biology, Indian Institute of; Science, Bangalore, India.; Azidothymidine ( AZT ), which has been extensively used as an antiviral agent in the treatment of AIDS, showed strong inhibition of growth of Sp2/0 cells in vitro. AZT-treated cells showed a decrease in viability in a dose-dependent manner. AZT specific
Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha.: Arthritis Rheum. 1996 Feb;39(2):197-203. Unique Identifier : AIDSLINE MED/96197002; Fujisawa K; Aono H; Hasunuma T; Yamamoto K; Mita S; Nishioka K; University School of Medicine, Kawasaki, Japan.; OBJECTIVE: To examine whether nuclear factor kappaB (NF-kappaB) is activated in cultured synovial cells in response to tumor necrosis factor alpha (TNFalpha) and to investigate the correlation between NF-kappaB activation and synovial cell proliferation. METHODS: Activation of NF-kappaB was detected by electrophoretic
A foveal-sparing pattern of cytomegalovirus retinitis in the acquired immunodeficiency syndrome.: Aust N Z J Ophthalmol. 1996 Feb;24(1):53-9. Unique Identifier : AIDSLINE MED/96303148; Luckie AP; Ai E; Department of Ophthalmology, California Pacific Medical Center,; San Francisco 94115, USA.; PURPOSE: We describe the clinical course of 12 eyes of 10 patients in whom recurrent cytomegalovirus ( CMV ) retinitis exhibited a foveal-sparing pattern. METHODS: We retrospectively reviewed the case records and photographic c
AIDS and the eye. A 10-year experience.: Aust N Z J Ophthalmol. 1996 Feb;24(1):61-7. Unique Identifier : AIDSLINE MED/96303149; Maclean H; Hall AJ; McCombe MF; Sandland AM; Melbourne University Department of Ophthalmology, Victoria.; BACKGROUND: The AIDS database at Fairfield Hospital, Melbourne, maintains information on eye pathology as identified by the three visiting ophthalmologists. Patients underwent an eye consultation: if they had ocular symptoms; if signs were seen on direct ophthalmoscopy by physicians; or when their CD4+ve cell count fe
Precipitous visual loss secondary to optic nerve toxoplasmosis as an unusual presentation of AIDS.: Aust N Z J Ophthalmol. 1996 Feb;24(1):75-7. Unique Identifier : AIDSLINE MED/96303152; Wei ME; Campbell SH; Taylor C; Ophthalmology Registrar, Princess Alexandra Hospital, Brisbane.; Life-threatening conditions requiring urgent medical treatment rarely present to the ophthalmologist. This case report describes a patient with precipitious visual loss as the primary complaint and which subsequently led to the diagnosis of Toxoplasmic papillitis and life-threatening cerebral involvement as an initial
Pharmacokinetics of fluconazole in people with HIV infection: a population analysis.: Br J Clin Pharmacol. 1996 Apr;41(4):291-8. Unique Identifier : AIDSLINE MED/96290719; McLachlan AJ; Tett SE; St Vincent's Hospital Darlinghurst, Australia.; 1. The population pharmacokinetics of fluconazole have been investigated in 113 male subjects with HIV infection and AIDS. Plasma concentration-time data (between 1 and 17 observations per dose) were collected from individuals as part of a pharmacokinetic investigation (13 subjects) or during routine fluconazole thera
Munchausen's syndrome and HIV infection: a trap for the unwary [letter]: Br J Clin Pract. 1996 Apr-May;50(3):176. Unique Identifier : AIDSLINE MED/96297558; Oyewole D
HIV-2 infection among blood and plasma donors--United States, June 1992-June 1995.: Oncology (Huntingt). 1995 Dec;9(12):1262-4. Unique Identifier : AIDSLINE MED/96366986
[The problem of HIV infections in children in the daily life in the hospital]: Kinderkrankenschwester. 1996 Feb;15(2):62-4. Unique Identifier : AIDSLINE MED/96327433; Solder B
Cutaneous Pneumocystis carinii and Cryptococcus neoformans in AIDS.: Br J Dermatol. 1996 Jan;134(1):159-63. Unique Identifier : AIDSLINE MED/96286939; Sandler B; Potter TS; Hashimoto K; Department of Dermatology, University of Michigan, Detroit, USA.; A patient with AIDS was found to have skin lesions which contained the organisms Pneumocystis carinii and Cryptococcus neoformans. Both organisms were identified using haematoxylin and eosin, Gomori methenamine silver, Giemsa and mucicarmine stains. Electron microscopy was performed and confirmed their presence. The c
Leishmania infection occurring in herpes zoster lesions in an HIV-positive patient.: Br J Dermatol. 1996 Jan;134(1):164-6. Unique Identifier : AIDSLINE MED/96286940; Barrio J; Lecona M; Cosin J; Olalquiaga FJ; Hernanz JM; Soto J; Dermatology and Pathology Services, Gregario Maranon General; Hospital, Madrid, Spain.; We report the first case of co-infection with herpes zoster and leishmania in the same lesion, on the face of a 29-year-old female, who was an intravenous drug user and who was HIV positive. The infection was initially resistant to acyclovir and itraconazole, and the patient die
HIV-associated eosinophilic folliculitis: case report and review of the literature.: Br J Dermatol. 1996 Mar;134(3):499-503. Unique Identifier : AIDSLINE MED/96297474; Basarab T; Russell Jones R; St John's Dermatology Centre, St Thomas' Hospital, London.; We report human immunodeficiency virus (HIV)-associated eosinophilic folliculitis in a previously well 40-year-old Portuguese lady. This condition, although similar to Ofuji s disease, has distinguishing features which allow the two to be differentiated. To the best of our knowledge, this is the first reported case of
Acute myelocytic leukaemia associated with Kaposi's sarcoma in a patient without serum antibodies to human immunodeficiency virus type 1.: Br J Dermatol. 1996 Mar;134(3):551-3. Unique Identifier : AIDSLINE MED/96297485; Hernandez DE; Pellino ML; Ramirez B; Department of Medicine, Universidad Central de Venezuela,; Caracas.; We report a 35-year-old man with acute myelocytic leukaemia and Kaposi s sarcoma, whose serum was non-reactive for antibodies to human immunodeficiency virus type-1 by enzyme-linked immunosorbent assay, Western blot and immunofluorescence. Complete remission of both the acute leukaemia and the Kaposi s sarcoma followe
Use of terbinafine in HIV-positive subjects: pilot studies in onychomycosis and oral candidiasis.: Br J Dermatol. 1996 Jun;134 Suppl 46:22-4: discussion 39. Unique Identifier : AIDSLINE MED/96296376; Nandwani R; Parnell A; Youle M; Lacey CJ; Evans EG; Midgley J; Cartledge J; Hawkins DA; St Stephen's Centre, Chelsea & Westminster Hospital, London, U.K.; Study 1. Eighteen HIV-positive Caucasian homosexual men with initial positive fungal microscopy were recruited into this prospective, dual-centre, open-label study. They received a once-daily oral dose of 250 mg terbinafine for 12 weeks. Eight were subsequently excluded after screening cultures proved negative. The me
The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.: Biochemistry. 1996 Aug 13;35(32):10256-61. Unique Identifier : AIDSLINE MED/96339295; Grzesiek S; Stahl SJ; Wingfield PT; Bax A; Laboratory of Chemical Physics, National Institute of Diabetes; and digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0520, USA.; Using heteronuclear NMR spectroscopy, we demonstrate that a 13-residue peptide (MS-QIKRLLSEKKT) from the cytoplasmic tail of CD4 binds to Nef protein. This part of CD4 is critical for downregulation of CD4 by HIV-1 Nef [Aiken et al. (1994) Cell 76, 853-864]. We show that a control peptide without the central dileucine
Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity.: Biochemistry. 1996 Aug 13;35(32):10279-86. Unique Identifier : AIDSLINE MED/96339298; Hoog SS; Towler EM; Zhao B; Doyle ML; Debouck C; Abdel-Meguid SS; Department of Macromolecular Sciences, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; To gain greater understanding of the structural basis of human immunodeficiency virus (HIV) protease ligand specificity, we have crystallized and determined the structures of the HIV-1 protease (Val32Ile, Ile47Val, Val82Ile) triple mutant and simian immunodeficiency virus (SIV) protease in complex with SB203386, a tri
Specific inhibition of in vitro transcription elongation by triplex-forming oligonucleotide-intercalator conjugates targeted to HIV proviral DNA.: Biochemistry. 1996 Aug 13;35(32):10539-48. Unique Identifier : AIDSLINE MED/96339325; Giovannangeli C; Perrouault L; Escude C; Nguyen T; Helene C; Laboratoire de Biophysique, Museum National d' Histoire; Naturelle, INSERM U 201, CNRS URA 481, Paris,; France.giovanna@mnhn.fr; A 16-base pair oligo(purine)-oligo(pyrimidine) sequence present in the coding region of two HIV 1 proviral genes (pol and nef) was chosen as a target for triplex-forming oligonucleotides in in vitro transcription assays. Inhibition of transcription elongation was observed with triplex-forming oligonucleotide-acridine
Molecular analysis of the second template switch during reverse transcription of the HIV RNA template.: Biochemistry. 1996 Aug 13;35(32):10549-57. Unique Identifier : AIDSLINE MED/96339326; Ben-Artzi H; Shemesh J; Zeelon E; Amit B; Kleiman L; Gorecki M; Panet A; BioTechnology General Ltd. Rehovot, Israel.; The molecular events leading to the second template switch during reverse transcription of the HIV genome were studied in a defined in-vitro system. In order to investigate displacement of the tRNA(lys) primer from the primer binding site (PBS) of the viral genomic RNA, following DNA synthesis, we produced an HIV RNA/
Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.: Biochemistry. 1996 Aug 20;35(33):10627-33. Unique Identifier : AIDSLINE PDB/1GNN; Hong L; Treharne A; Hartsuck JA; Foundling S; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; University of Oklahoma Health Sciences Center, Oklahoma City; 73104, USA.; Crystal structures of the protease of human immunodeficiency virus type 1 (HIV-1) and two mutant proteases, V82D and V82N, have been determined. In all three cases the enzyme forms a complex with the peptidic inhibitor U-89360E. All structures have been determined to 2.3 A resolution and have satisfactory agreement fa
Different patterns in donor-specific production of T-helper 1 and 2 cytokines by cells infiltrating the rejecting cardiac allograft.: J Heart Lung Transplant. 1995 Sep-Oct;14(5):816-23. Unique Identifier : AIDSLINE MED/96116094; van Besouw NM; Daane CR; Vaessen LM; Balk AH; Claas FH; Zondervan PE; Jutte NH; Weimar W; Department of Internal Medicine, Erasmus University Rotterdam,; The Netherlands.; BACKGROUND: Cytokines play an important role in allograft rejection. The local production of cytokines by T-helper 2 cells within an allograft could influence the induction of graft rejection. METHODS: Therefore we studied the in vitro production of cytokines by cells infiltrating the graft. graft-infiltrating cell cu
Adenovirus-mediated interferon-gamma transfer inhibits growth of transplanted HTLV-1 Tax tumors in mice.: Hum Gene Ther. 1996 Mar 1;7(4):471-7. Unique Identifier : AIDSLINE MED/96236786; Xu X; Dai Y; Heidenreich O; Nerenberg MI; Department of Molecular and Experimental Medicine, Scripps; Research Institue, La Jolla, CA 92037, USA.; Human T cell leukemia virus type 1 (HTLV-1) causes adult T cell leukemia (ATL), and the virus-encoded trans-activator, Tax, plays an important role in T cell transformation. In the HTLV-1 long terminal repeat (LTR)-Tax transgenic mouse model, Tax expression causes fibroblastic tumors. A tumor-derived cell line (B line
Oral mucosal Langerhans' cells.: Crit Rev Oral Biol Med. 1996;7(1):36-58. Unique Identifier : AIDSLINE MED/96338480; Barrett AW; Cruchley AT; Williams DM; Department of Oral Pathology, Eastman Dental Institute for Oral; Health Care Sciences, London, U.K.; Langerhans cells (LC) are dendritic, antigen-presenting cells present within the epithelium of skin and mucosa, including that of the oral cavity. This article reviews the literature on the phenotypic and functional features of oral mucosal Langerhans cells, and speculates on other aspects by extrapolating from data
Knowledge at the bedside: a feminist view of what's happening with this patient.: J Clin Ethics. 1996 Spring;7(1):20-8. Unique Identifier : AIDSLINE MED/96382830; Nelson HL; Department of Philosophy at the University of Tennessee,; Knoxville, USA.
The ethics of mandatory HIV testing in newborns [see comments]: J Clin Ethics. 1996 Spring;7(1):77-84. Unique Identifier : AIDSLINE MED/96382838; Berger JT; Rosner F; Farnsworth P; Winthrop-University Hospital, Mineola, N.Y., USA.
Rethinking the testing of babies and pregnant women for HIV infection [see comments]: J Clin Ethics. 1996 Spring;7(1):85-6. Unique Identifier : AIDSLINE MED/96382839; Bayer R; Columbia University School of Public Health in New York City,; USA.
Is "informed right of refusal" the same as "informed consent"? [comment]: J Clin Ethics. 1996 Spring;7(1):87-9. Unique Identifier : AIDSLINE MED/96382840; Truog RD; Children's Hospital, Boston, USA.
Legal trends in bioethics.: J Clin Ethics. 1996 Spring;7(1):90-4. Unique Identifier : AIDSLINE MED/96382841; Davis DS; Cleveland-Marshall College of Law, Cleveland State University,; Ohio, USA.
Mortality attributable to HIV infection among persons aged 25-44 years--US, 1994 [news]: Ann Pharmacother. 1996 May;30(5):564. Unique Identifier : AIDSLINE MED/96309770
A visual inspection protocol for measuring characteristics of used syringes.: J Subst Abuse. 1995;7(3):319-29. Unique Identifier : AIDSLINE MED/96357421; Guydish J; Garcia D; Clark G; Young M; Institute for Health Policy Studies, University of California at; San Francisco CA 94109, USA.; This article reports on the use of a Visual Inspection Protocol (VIP) to measure observable characteristics of syringes deposited at the San Francisco needle exchange program. Syringes received by the program were evaluated by several inspectors using the VIP, and interrater reliability was assessed for each item. In
HIV-1 subtype O: epidemiology, pathogenesis, diagnosis, and perspectives of the evolution of HIV.: Arch Virol Suppl. 1996;11:195-202. Unique Identifier : AIDSLINE MED/96379548; Gurtler LG; Zekeng L; Tsague JM; van Brunn A; Afane Ze E; Eberle J; Kaptue L; Max von Pettenkofer Institute for Hygiene and Medical; Microbiology, University of Munich, Federal Republic of Germany.; HIV-1 subtype O is a new HIV variant originating in the West-Central African region, with highest prevalences in countries such as Cameroon , Equatorial Guinea and Gabon . Detection of antibodies to HIV-1 sub
Clinical and immunological studies in advanced cancer patients sequentially treated with anti CD3 monoclonal antibody (OKT3) and interleukin-2.: Leuk Lymphoma. 1996 Apr;21(3-4):325-30. Unique Identifier : AIDSLINE MED/96292500; Borrione P; Montacchini L; Beggiato E; Pileri A; Bianchi A; Massaia M; Universita di Torino, Dipartimento di Medicine e Oncologia; Sperimentale, Ospedale Molinette, Torino, Italy.; CD3 engagement has been used as a surrogate for antigen-specific stimulation to trigger T cell effector functions. Exogenous IL-2 has been used to prolong and amplify CD3-induced T cell activation. Previous studies have been shown that CD3 reactivity is increased in ca
Teaching cases from the Royal Marsden and St Mary's Hospital case 11 dysplastic neutrophils in an African women.: Leuk Lymphoma. 1996 Apr;21(3-4):351-2. Unique Identifier : AIDSLINE MED/96292505; Ozanne C; Bain B; Catovksy D; Department of Haematology, St Mary's Hospital Medical School,; London.
Role of beta 2-glycoprotein I in the anticardiolipin antibody affinity for phospholipid in autoimmune disease.: Lupus. 1995 Dec;4(6):477-81. Unique Identifier : AIDSLINE MED/96353211; Dueymes M; Piette JC; Le Tonqueze M; Bendaoud B; Roue R; Garre M; Youinou P; Laboratory of Immunology, Brest University Medical School,; France.; The binding capacity to cardiolipin and the functional affinity of affinity-purified anticardiolipin (aCL) IgG of patients with autoimmune disease have been compared with those of individuals with malaria and acquired immunodeficiency syndrome (AIDS). The binding of autoimmune IgG aCL was enhanced gradually by the inc
PCR detection of HIV.: Methods Mol Biol. 1996;50:93-107. Unique Identifier : AIDSLINE MED/96281789; Boni J; Swiss National Center for Retroviruses, University of Zurich,; Switzerland.
[HIV and AIDS. Legal and social aspects of care]: Pflege Z. 1996 Mar;49(3):suppl 2-12. Unique Identifier : AIDSLINE MED/96334637
Modelling HIV vaccination.: Trends Microbiol. 1995 Dec;3(12):458-62. Unique Identifier : AIDSLINE MED/96178384; McLean AR; Blower SM; Zoology Department, Oxford University, Oxford, UK.; Relatively recently, mathematical models have been applied to issues r elated to HIV vaccination. Significant progress has been made towards understanding how rather ineffective vaccines will perform in trials and in the community, but some areas still need research.
Is the Nef protein of HIV-1 required for pathogenesis?: Trends Microbiol. 1996 May;4(5):171-2; discussion 173. Unique Identifier : AIDSLINE MED/96324045; Miller MD; Greene WC; Gladstone Institute of Virology and Immunology, San Francisco, CA; 94141, USA. Michael_Miller@quickmail.ucsf.edu
Human immunodeficiency virus-related bacillary angiomatosis of the penis.: Br J Urol. 1996 Feb;77(2):323-4. Unique Identifier : AIDSLINE MED/96245961; Eden CG; Marker A; Pryor JP; Department of Urology, King's College Hospital, London, UK.
The spectrum of meningitis in a population with high prevalence of HIV disease.: QJM. 1996 Jul;89(7):499-504. Unique Identifier : AIDSLINE MED/96336220; Bergemann A; Karstaedt AS; Department of Medicine, Baragwanath Hospital, Johannesburg, South; Africa.; We studied the spectrum of meningitis and impact of HIV infection retrospectively (8 months) and prospectively (4 months) in 284 adult patients with meningitis hospitalized in Soweto, South Africa . Tuberculous meningitis (TBM) was the most common cause of meningitis (25.4%) follow
CD4 and total lymphocyte counts as predictors of HIV disease progression.: QJM. 1996 Jul;89(7):505-8. Unique Identifier : AIDSLINE MED/96336221; Post FA; Wood R; Maartens G; Department of Medicine, University of Cape Town Medical School,; South Africa.; CD4+ T-lymphocyte (CD4) counts are a standard laboratory marker of disease progression in HIV infection, but expense precludes their use in large parts of the world. Total lymphocyte counts (TLC), in contrast, are widely available. We compared CD4 and TLC counts as predictors of developing AIDS or death in 831 HIV-pos
Pharmacists' provision of continuity of care to patients with human immunodeficiency virus infection.: Am J Health Syst Pharm. 1996 May 1;53(9):1013-7. Unique Identifier : AIDSLINE MED/96303607; Foisy MM; Tseng A; Blaikie N; Faculty of the Doctor of Pharmacy Program, University of Toronto,; Ontario, Canada.; A pharmacy program for providing continuity of care to patients infected with human immunodeficiency virus (HIV) is described. The program was implemented at three practice sites in Toronto: a tertiary care teaching hospital; an outpatient community pharmacy that is part of the hospital; and an ambulatory care clinic
Indinavir marketed under accelerated-approval program [news]: Am J Health Syst Pharm. 1996 May 1;53(9):982. Unique Identifier : AIDSLINE MED/96303597
Relationship between sex steroid hormone levels and CD4 lymphocytes in HIV infected men.: Exp Clin Endocrinol Diabetes. 1996;104(2):130-6. Unique Identifier : AIDSLINE MED/96303649; Christeff N; Lortholary O; Casassus P; Thobie N; Veyssier P; Torri O; Guillevin L; Nunez EA; U.224, INSERM affiliee au CNRS-C.H.U. Bichat, Paris, France.; The serum concentrations of the steroid, androgens and estrogens, in the HIV-positive male patients were studied. These men belonged to one of the three main behaviour groups: heterosexual (He), drug addicts (DA) and homosexual (Ho) at early stages (II and III) or at advanced stage of AIDS (IVC), classified according
Is HIV screening being requested appropriately? The experience of a Victorian public health laboratory.: Aust N Z J Public Health. 1996 Jun;20(3):247-53. Unique Identifier : AIDSLINE MED/96349539; Darlington R; Thompson SC; Forsyth JR; Microbiological Diagnostic Unit, University of Melbourne,; Parkville, Vic.; From the start of clinical testing for human immunodeficiency virus (HIV) antibody in 1985 until the end of June 1994, the Microbiological Diagnostic Unit tested 134 346 serum samples from 109 391 individuals, identifying 672 as infected. A suitable database, using coded identities, was established from the beginning.
HIV testing at a gay men's clinic, Melbourne [letter]: Aust N Z J Public Health. 1996 Jun;20(3):323-4. Unique Identifier : AIDSLINE MED/96349554; Carmody C; MacDonald M
Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival.: Cancer Res. 1996 Sep 1;56(17):3862-5. Unique Identifier : AIDSLINE MED/96354598; Iwamoto KS; Mizuno T; Ito T; Tsuyama N; Kyoizumi S; Seyama T; Department of Radiobiology, Radiation Effects Research; Foundation, Hiroshima, Japan.; Missense mutations are by the far the most common types of mutations found in p53 of human tumors, suggesting that mutant p53 proteins function either by abrogating wild-type function or by gaining new oncogenic functions. To distinguish between the dominant-negative effect and gain of new function of p53 missense mut
Interleukin 2 production in vitro by peripheral lymphocytes in response to human papillomavirus-derived peptides: correlation with cervical pathology.: Cancer Res. 1996 Sep 1;56(17):3967-74. Unique Identifier : AIDSLINE MED/96354617; Tsukui T; Hildesheim A; Schiffman MH; Lucci J 3rd; Contois D; Lawler P; Rush BB; Lorincz AT; Corrigan A; Burk RD; Qu W; Marshall MA; Mann D; Carrington M; Clerici M; Shearer GM; Carbone DP; Scott DR; Houghten RA; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, Maryland 20892, USA.; Human papillomavirus (HPV) is believed to be the major cause of cervical cancer. To investigate whether a cellular immune response, especially a T helper type 1 response, is related to the natural defense against HPV-related cervical lesions, the interleukin 2 response of peripheral blood lymphocytes in vitro to overl
[A study of the association between EBV and B-cell lymphoma]: Chung Hua Ping Li Hsueh Tsa Chih. 1996 Feb;25(1):4-6. Unique Identifier : AIDSLINE MED/96286751; Zhou X; Zhang J; Yan Q; Department of Pathology, Beijing Hospital.; Extensive studies have demonstrated that Epstein-Barr virus (EBV) is associated with Burkitt s lymphoma, immunodeficiency related lymphoma, Hodgkin s disease and T-cell lymphoma. In order to investigate whether an association exists between EBV and B-cell lymphoma in patients without overt immunodeficiency, we examine
Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin.: Clin Exp Dermatol. 1996 Mar;21(2):104-11. Unique Identifier : AIDSLINE MED/96336845; De Rie MA; Cairo I; Van Lier RA; Bos JD; Academic Medical Center, University of Amsterdam, The; Netherlands.; Activated T lymphocytes are thought to be involved in the pathogenesis of psoriasis. From studies with peripheral blood T lymphocytes it is known that T cells show a decrease in membrane expression of CD27 molecules during continuous antigenic stimulation. The T-cell activation molecule CD28 is thought to be involved
Mechanism for dendritic cell dysfunction in retroviral infection of mice.: Clin Immunol Immunopathol. 1996 Aug;80(2):139-46. Unique Identifier : AIDSLINE MED/96292190; Gabrilovich DI; Patterson S; Timofeev AV; Harvey JJ; Knight SC; Antigen Presentation Group, Imperial College of Science,; Technology, and Medicine, Middlesex, United Kingdom.; Dendritic cells (DC) from mice infected with the murine retrovirus Rauscher leukaemia virus (RLV) are poor stimulators of allogeneic and syngeneic T cells and express lower, but still significant, levels of MHC class II. In this paper we further investigated the mechanism of the dysfunction of DC. DC from infected ani
Induction of HIV-1 expression in chronically infected promonocytic cells cocultured with human lung fibroblasts.: Clin Immunol Immunopathol. 1996 Aug;80(2):171-8. Unique Identifier : AIDSLINE MED/96292194; Ho WZ; Li YH; Zhu XH; Song L; Douglas SD; Department of Pediatrics, Children's Hospital of Philadelphia,; University of Pennsylvania Medical School 19104, USA.; The interaction between a chronically human immunodeficiency virus type 1 (HIV-1)-infected promonocytic line (U1) and a normal human embryonic lung fibroblast line (MRC-5) on HIV-1 expression was investigated. Coculture of U1 cells with MRC-5 cells induced HIV-1 reverse transcriptase (RT) activities 40- to 50-fold hig
HIV-associated lesions.: Dermatol Clin. 1996 Apr;14(2):319-26. Unique Identifier : AIDSLINE MED/96308962; Greenberg MS; Department of Oral Medicine, University of Pennsylvania School of; Dental Medicine, Philadelphia, USA.; Oral lesions are common in HIV infection and may be the first sign of AIDS. This article reviews the oral fungal and viral infections commonly detected in HIV-infected patients, particularly candidiasis, deep fungal infections, herpes simplex virus infections, cytomegalovirus infec
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection.: Clin Exp Rheumatol. 1995 Nov-Dec;13 Suppl 13:S157-9. Unique Identifier : AIDSLINE MED/96281111; Antinori S; Galimberti L; Rusconi S; Zehender G; Esposito R; Galli M; Clinica delle Malattie Infettive, Universita di Milano, Italy.; OBJECTIVE. We report the case of a woman with long-lasting mixed cryoglobulinemic syndrome, who experienced clinical and laboratory remission of her cryoglobulinemia after becoming infected with human immuno-deficiency virus and developing HIV-1 induced immunosuppression. METHODS. Serum cryoglobulin concentrations and
Monoclonal gammopathies antigen driven in autoimmune diseases.: Clin Exp Rheumatol. 1996 Jan-Feb;14 Suppl 14:S37-44. Unique Identifier : AIDSLINE MED/96280250; Osterland CK; Division of Clinical Immunology and Rheumatology, Royal Victoria; Hospital, Montreal, Quebec, Canada.; An important link exists between cancer, autoimmune diseases and immune deficiency. This presentation will review some data concerning clonal growth in B lymphocytes, with focus on the occurrence of autoantibody f2p4vity in the monoclonal proteins, which are the products of the clonally expanded lymphocyte plasma cell
Pleural leak localization with Tc-99m pentetate aerosol in an AIDS patient with Pneumocystis carinii pneumonia.: Clin Nucl Med. 1996 May;21(5):408-9. Unique Identifier : AIDSLINE MED/96309912; Cartland JP; Benson B; Templeton Radiology Medical Group, CA 93465, USA.
Incidence and significance of acid-fast bacilli in sputum smears at the end of antituberculous treatment.: Chest. 1996 Jun;109(6):1562-5. Unique Identifier : AIDSLINE MED/96365335; Vidal R; Martin-Casabona N; Juan A; Falgueras T; Miravitlles M; Department of Pneumology, Ciutat Sanitaria Universitaria Vall; d'Hebron,Barcelona, Spain.; OBJECTIVE: A group of patients with pulmonary tuberculosis (PT) who received and correctly completed antituberculous therapy were studied to determine the incidence and significance of positive acid-fast bacilli (AFB) in sputum smears at the end of this treatment. DESIGN: Retrospective chart review of persons with bac
Outcome of AIDS patients requiring mechanical ventilation predicted by recursive partitioning.: Chest. 1996 Jun;109(6):1584-90. Unique Identifier : AIDSLINE MED/96365338; El-Solh, AA; Stubeusz DL; Grant GB; Grant JB; Department of Medicine, State University of New York at Buffalo,; USA.; Mechanical ventilatory support (VS) is often required for patients with AIDS. Patients, and/or their surrogates often ask the likely outcome of this intervention. To answer this question, we have developed a classification tree using clinical data from 71 patients with AIDS identified from the discharge abstracts of t
[Virus burden determines the prognosis of an HIV infection (news)]: Dtsch Med Wochenschr. 1996 Aug 16;121(33):A10. Unique Identifier : AIDSLINE MED/96375117; Muller HE
[The effect of birth-specific factors on the transfer of the HIV-1 virus from mother to child (news)]: Dtsch Med Wochenschr. 1996 Aug 16;121(33):A11. Unique Identifier : AIDSLINE MED/96375118; Morike EM
[DFG promotes AIDS research (news)]: Dtsch Med Wochenschr. 1996 Aug 16;121(33):A11-2. Unique Identifier : AIDSLINE MED/96375119; Schmidt D
Overview: viral agents and cancer.: Environ Health Perspect. 1995 Nov;103 Suppl 8:259-61. Unique Identifier : AIDSLINE MED/96343288; Mueller N; Harvard School of Public Health, Boston, Massachusetts, USA.; mueller@episun1.harvard.edu; Substantial evidence indicates that several common viruses are clearly or probable causal factors in the etiology of specific malignancies. These viruses either normally establish latency or can become persistent infections. Oncogenesis is probably linked to an enhanced level of viral activation in the infected host,
Viruses and human cancers: challenges for preventive strategies.: Environ Health Perspect. 1995 Nov;103 Suppl 8:269-73. Unique Identifier : AIDSLINE MED/96343290; de The G; Fogarty International Center, National Institutes of Health,; Bethesda, Maryland and Institut Pasteur, Unit of Epidemiology of; Oncogenic Viruses, Paris, France. dethe@pasteur.fr; Virus-associated human cancers provide unique opportunities for preventive strategies. The role of human papilloma viruses (HPV 16 and 18), hepatitis B virus (HBV), Epstein-Barr herpes virus (EBV), and retroviruses (human immunodeficiency virus [HIV] and human T-cell leukemia/lymphoma virus [HTLV]) in the development
Multiple recurrent bacillary angiomatosis due to Bartonella quintana in an HIV-infected patient [letter]: Eur J Clin Microbiol Infect Dis. 1996 Feb;15(2):178-80. Unique Identifier : AIDSLINE MED/96262431; Colson P; Lebrun L; Drancourt M; Boue F; Raoult D; Nordmann P
Mother-to-infant transmission of hepatitis C virus: a prospective study.: Eur J Pediatr. 1995 Dec;154(12):973-8. Unique Identifier : AIDSLINE MED/96255821; Matsubara T; Sumazaki R; Takita H; Department of Paediatrics, Institute of Clinical Medicine,; University of Tsukuba, Japan.; To investigate the risk of mother-to-infant transmission of hepatitis C virus (HCV) and the natural course of HCV-infected infants, we prospectively studied 31 offspring of pregnant women who were anti-HCV positive and anti-HIV negative. Sera were serially tested for anti-HCV by the second-generation ELISA-test (ELISA
Immunotoxic effects of prolonged dietary exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin.: Eur J Pharmacol. 1995 Dec 7;293(4):429-37. Unique Identifier : AIDSLINE MED/96352839; Badesha JS; Maliji G; Flaks B; Environmental Toxicology Centre, Faculty of Medicine, University; of Bristol, Langford, UK.; The effects of low level exposure of rats to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on their immune system was investigated Dietary administration to young adult male Leeds strain rats of a total dose of 3 micrograms/kg body weight of TCDD resulted in an exposure duration-dependent reduction of in vitro lipopolys
[HIV infection in women and children]: Epidemiol Prev. 1996 Apr-Sep;20(2-3):131-2. Unique Identifier : AIDSLINE MED/96345745; Giaquinto C; Dipartimento di Pediatria, Universita degli Studi di Padova.
[AIDS as a problem of great relevance for women's health]: Epidemiol Prev. 1996 Apr-Sep;20(2-3):133-5. Unique Identifier : AIDSLINE MED/96345746; Conti S; Farchi G; Galletti A; Rezza G; Prati S; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Roma.
[HIV and Kaposi's sarcoma in women in Europe]: Epidemiol Prev. 1996 Apr-Sep;20(2-3):136-7. Unique Identifier : AIDSLINE MED/96345747; Dal Maso L; Serraino D; Franceschi S; Servizio di Epidemiologia, Centro di Riferimento Oncologico di; Aviano.
[Gender differences in the outcomes of drug dependence in Turin]: Epidemiol Prev. 1996 Apr-Sep;20(2-3):267-8. Unique Identifier : AIDSLINE MED/96345791; Ciminale M; Lemma P; Faggiano F; Dipartimento di Igiene, e Medicina di Communita, Universita di; Torino.
[Pregnancy care in drug-dependent patients under the charge of SERT (Public Service for the Treatment of Drug Addiction) of Massa-Carrara. The prevention of fetal damages and premature labor]: Epidemiol Prev. 1996 Apr-Sep;20(2-3):86-8. Unique Identifier : AIDSLINE MED/96345729; Damone R; Angelotti L; Giusti P; Luzzoli RM; Previtera G; Zannoni C; Migliorini P; SERT ASL 1, Massa Carrara.
Inhibition mechanisms of HIV-1, Mo-MuLV and AMV reverse transcriptases by Kelletinin A from Buccinulum corneum.: Experientia. 1996 Aug 15;52(8):812-7. Unique Identifier : AIDSLINE MED/96370858; Orlando P; Strazzullo G; Carretta F; De Falco M; Grippo P; Istituto Biochimica delle Proteine ed Enzimologia, CNR, Arco; Felice, Naples, Italy.; Kelletinin A [ribity pentakis (p-hydroxybenzoate)] (KA), an inhibitor of HTLV-1 replication isolated from Buccinulum corneum, showed a noncompetitive inhibitory activity with respect to the template primer and to dTTP in the poly(rA).oligo(dT)12-18-directed reaction of HIV-1, Mo-MuLV and AMV reverse transcriptases (RT
Co-dominant inheritance of hyperekplexia and spastic paraparesis.: Dev Med Child Neurol. 1996 Aug;38(8):739-43. Unique Identifier : AIDSLINE MED/96350202; Baxter P; Connolly S; Curtis A; Spencer V; Ravindranath C; Burn J; Gardner-Medwin D; Department of Paediatric Neurology, Newcastle General Hospital,; Newcastle upon Tyne, UK.; In four generations of a family with autosomal dominant hyperekplexia (startle disease), untreated affected adult members had pes cavus and extensor plantar responses, as well as hyper-reflexia. Electroencephalography during a startle, electromyography, nerve conduction velocities and somatosensory evoked potentials w
The contribution of vitamin A to public health.: FASEB J. 1996 Jul;10(9):1040-8. Unique Identifier : AIDSLINE MED/96388959; Underwood BA; Arthur P; Wold Health Organization, Geneva, Switzerland.; Vitamin A deficiency among children in developing countries remains the leading cause of preventable severe visual impairment and blindness, and is a significant contributor to severe infections and death, particularly from diarrhea and measles. Vitamin A deficiency is also likely to increase vulnerability to other il
Faecal alpha 1 antitrypsin as a marker of gastrointestinal disease in HIV antibody positive individuals.: Gut. 1996 Feb;38(2):206-10. Unique Identifier : AIDSLINE MED/96246358; Sharpstone D; Rowbottom A; Nelson M; Gazzard B; Department of HIV/GUM, Chelsea and Westminster Hospital, London.; Hypoalbuminaemia and diarrhoea are common complications of HIV infection and substantial causes of morbidity, but the specific intestinal pathologies that cause enteric protein loss have not been clearly defined. Two hundred and twenty stool samples from patients with a variety of HIV related conditions were analysed
Gay men with AIDS and their families of origin: an analysis of social support.: Health Soc Work. 1996 May;21(2):141-9. Unique Identifier : AIDSLINE MED/96276606; Kadushin G; School of Social Welfare, University of Wisconsin-Milwaukee; 53201, USA.; This article reviews the literature on the relationships between gay men with AIDS and their families of origin to determine why the family is not a principal source of social support. Several reasons explain the absence of the family from the support network, including the family s lack of acceptance of homosexuality
Septata intestinalis and Encephalitozoon cuniculi: cross-reactivity between two microsporidian species.: Folia Parasitol (Praha). 1995;42(3):169-72. Unique Identifier : AIDSLINE MED/96370877; Schottelius J; Lo Y; Schmetz C; Section of Parasitology, Bernhard-Nocht-Institute for Tropical; Medicine, Hamburg, Germany.; An infection with Septata intestinalis was diagnosed in a 35-year-old AIDS patient without diarrhoea. The diagnosis was based on morphological examinations of a duodenal biopsy specimen. Serum antibodies were detected reacting with spores of Encephalitozoon cuniculi. Spores of S. intestinalis and E. cuniculi stained w
Primary cytotoxic T-cell responses to bovine respiratory syncytial virus in calves.: Immunology. 1996 Jul;88(3):421-7. Unique Identifier : AIDSLINE MED/96370464; Gaddum RM; Cook RS; Thomas LH; Taylor G; Institute for Animal Health, Compton, Newbury, Berkshire, UK.; Bovine respiratory syncytial virus (RSV) is a major cause of respiratory disease in young calves. Recent studies in calves, in which different T-cell subsets were depleted, have shown that CD8+ T cells play a central role in recovery from RSV infection. The present study demonstrates that RSV-specific, major histocomp
Opsonization of Cryptococcus neoformans by human anticryptococcal glucuronoxylomannan antibodies.: Infect Immun. 1996 Sep;64(9):3446-50. Unique Identifier : AIDSLINE MED/96355845; Zhong Z; Pirofski LA; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York 10461, USA.; Cryptococcal meningitis occurs in 6 to 8% of human immunodeficiency virus-infected individuals. Despite the availability of powerful antifungal agents that are active against Cryptococcus neoformans, these drugs generally fail to cure cryptococcal infections in immun
Anti-interleukin-4 modulation of the Th2 polarized response to the parasitic nematode Brugia pahangi.: Infect Immun. 1996 Sep;64(9):3461-6. Unique Identifier : AIDSLINE MED/96355847; Osborne J; Hunter SJ; Devaney E; Department of Veterinary Parasitology, University of Glasgow,; Scotland, United Kingdom.; Lymphatic filariasis is a chronic disease characterized by a pronounced Th2 bias in the immune response and impaired antigen (Ag)-specific Th1 responses. We have used a mouse model of filariasis to investigate the role of the infective form (the third-stage larvae [L3]) in modulating the immune response. Subcutaneous
Interleukin-12 regulation of host defenses against Coccidioides immitis.: Infect Immun. 1996 Sep;64(9):3609-13. Unique Identifier : AIDSLINE MED/96355868; Magee DM; Cox RA; Department of Clinical Investigation, Texas Center for Infectious; Diseases, San Antonio 78223, USA. mmagee@tcid.tdh.state.tx.us; We have previously reported on the alternate regulation of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in inbred mouse strains which differ in their susceptibility to Coccidioides immitis. The genetically resistant DBA/2 mice manifest a predominant T-helper 1 (Th1) response, with early production of IFN-gamm
CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes.: Infect Immun. 1996 Sep;64(9):3632-40. Unique Identifier : AIDSLINE MED/96355872; Harty JT; Bevan MJ; Department of Microbiology, University of Iowa, Iowa City 52242,; USA. john-harty@uiowa.edu; CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytog
Gastric invasion by Trypanosoma cruzi and induction of protective mucosal immune responses.: Infect Immun. 1996 Sep;64(9):3800-10. Unique Identifier : AIDSLINE MED/96355894; Hoft DF; Farrar PL; Kratz-Owens K; Shaffer D; Department of Internal Medicine, Saint Louis University Health; Sciences Center, Missouri 63110, USA. hoftdf@sluvca.slu.edu; Trypanosoma cruzi is an intracellular parasite transmitted from a reduviid insect vector to humans by exposure of mucosal surfaces to infected insect excreta. We have used an oral challenge murine model that mimics vector-borne transmission to study T. cruzi mucosal infection. Although gastric secretions have microbic
Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.: Infect Immun. 1996 Sep;64(9):3845-52. Unique Identifier : AIDSLINE MED/96355899; Norgard MV; Arndt LL; Akins DR; Curetty LL; Harrich DA; Radolf JD; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235, USA.; There is increasing evidence that lipoproteins of Treponema pallidum and Borrelia burgdorferi are key inflammatory mediators during syphilis and Lyme disease. A principal objective of the present study was to identify more precisely similarities and divergences among lipopolysaccharide (LPS)- and lipoprotein-lipopepti
Zidovudine absorption and small intestinal function in HIV seropositive patients.: J Antimicrob Chemother. 1996 Apr;37(4):825-9. Unique Identifier : AIDSLINE MED/96293986; Macnab KA; Gill MJ; Sutherland LR; Murphy A; Brant R; Department of Family Medicine, University of Calgary, Calgary,; Alberta, Canada.; Zidovudine absorption was evaluated in HIV seropositive patients with (n = 15) and without diarrhoea (n = 20) in a standardised prospective pharmacokinetic study using single oral 200 mg doses. Zidovudine was rapidly absorbed with large peak variation (Cmax: 1.10 +/- 0.43 mg/L). There were no significant associations
The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase.: J Biol Chem. 1996 Aug 16;271(33):19860-4. Unique Identifier : AIDSLINE MED/96355286; Arion D; Borkow G; Gu Z; Wainberg MA; Parniak MA; Lady Davis Institute for Medical Research, Jewish General; Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, H3T 1E2; Canada.; The K65R mutation in HIV-1 reverse transcriptase (RT) is associated with viral cross-resistance to 2 ,3 -dideoxyinosine, 2 ,3 -dideoxycytidine, and 2 ,3 -dideoxy-3 -thiacytidine. We have found that in vitro DNA synthesis by K65R RT is significantly more processive than that of wild type (wt) RT. Depending on the templ
The putative substrate recognition loop of Escherichia coli ribonuclease H is not essential for activity.: J Biol Chem. 1996 Aug 16;271(33):19883-7. Unique Identifier : AIDSLINE MED/96355290; Keck JL; Marqusee S; Division of Biochemistry and Molecular Biology, University of; California, Berkeley, California 94720, USA.; The RNase H family of enzymes catalyzes the hydrolysis of RNA from RNA DNA hybrids in a divalent metal-dependent fashion. To date, structure/function studies have focused on two members of this family: Escherichia coli RNase HI, a small monomeric protein; and human immunodeficiency virus, type I (HIV) RNase H, a domai
Quantification of HIV-1 proviral DNA and analysis of genomic diversity by polymerase chain reaction and temperature gradient gel electrophoresis.: J Virol Methods. 1996 Apr 5;57(2):127-39. Unique Identifier : AIDSLINE MED/96261559; Wieland U; Suhr H; Salzberger B; Eggers HJ; Braun RW; Kuhn JE; Institut fuer Virologie, Universitaet zu Koeln, Germany.; A competitive polymerase chain reaction/temperature gradient gel electrophoresis (PCR/TGGE) protocol was developed for exact quantification of HIV-1 proviral DNA copy numbers in clinical samples. An internal standard (ST) that differs from wildtype-sequences only by a single base exchange was used as a competitor in P
Presence of antibodies to p21X and/or p27rex proteins in sera from human T-cell leukemia virus type I-infected individuals.: J Virol Methods. 1996 Apr 5;57(2):157-68. Unique Identifier : AIDSLINE MED/96261561; Saiga A; Aono Y; Imai J; Kinoshita K; Orita S; Igarashi H; Shionogi Institute for Medical Science, Osaka, Japan.; The human T-cell leukemia virus type I (HTLV-I) pX gene encodes three nonstructural proteins, p40tax, p27rex and p21X. So far, natural antibodies to p27rex and/or p21X have not been found in sera from HTLV-I-infected individuals, although antibodies to p40tax have been found. Recently, the viral transcripts specific f
Nonparametric expectation maximization population modeling of ganciclovir.: J Clin Pharmacol. 1996 Apr;36(4):301-10. Unique Identifier : AIDSLINE MED/96291634; Preston SL; Drusano GL; Department of Pharmacy Practice, Albany College of Pharmacy, NY; 12208, USA.; The use of the nonparametric expectation maximization (NPEM2) program to estimate pharmacokinetic parameters of ganciclovir in a group of patients with human immunodeficiency virus (HIV) and cytomegalovirus ( CMV ) infection wa
Immunohistochemical study of cellular events in lesional skin during common virus infections.: J Dermatol. 1996 Jan;23(1):22-32. Unique Identifier : AIDSLINE MED/96287926; Tsukahara T; Horiuchi Y; Department of Dermatology, Kitasato University School of; Medicine, Sagamihara, Japan.; Determination was made of epidermal Langerhans cell (LC) distribution and infiltrating cellular events in lesional skin during varicella zoster virus (VZV) infection, and the results were compared with those for herpes simplex (HS), measles, and rubella by immunohistochemical staining with cell surface markers. CD1a p
Two cases of metastatic malignant melanoma of the lower limb treated with hyperthermic isolated limb perfusion and concomitant infusion of either carboplatin or beta-interferon.: J Dermatol. 1996 Jan;23(1):6-15. Unique Identifier : AIDSLINE MED/96287924; Nakayama J; Takeuchi M; Mayumi H; Nagae S; Matsuda K; Yasui H; Takahashi S; Hori Y; Department of Dermatology, Kyushu University Faculty of Medicine,; Fukuoka, Japan.; Two cases of metastatic malignant melanoma of the lower limb who were treated successfully with hyperthermic isolated limb perfusion are reported. One patient was infused with cisdiammine (1.1-cyclobutanedicarboxylate) platinum (II) (carboplatin, Paraplatin, Bristol-Myers Squibb Compan
Quantitative assessment of the human TCRBV repertoire by competitive PCR.: J Immunol Methods. 1996 Aug 14;194(2):155-68. Unique Identifier : AIDSLINE MED/96350591; Uhrberg M; Wernet P; Bone Marrow Donor Center, MED-Heinrich-Heine University,; Dusseldorf, Germany.; A novel quantitative protocol was developed for the measurement of the relative expression levels of the human TCRBV genes based on reverse transcription (RT) and subsequent competitive polymerase chain reaction (cPCR). Competitor DNA templates for the analysis of 24 different TCRBV families were generated by a simple
Collagenase and Dispase enzymes disrupt lymphocyte surface molecules.: J Immunol Methods. 1996 Aug 14;194(2):211-6. Unique Identifier : AIDSLINE MED/96350596; Abuzakouk M; Feighery C; O'Farrelly C; Department of Immunology, St. James's Hospital, Dublin, Ireland.; Collagenase and Dispase enzymes are often used to disaggregate tissue. In this study, we examined by flow cytometry the effects of these enzyme preparations on peripheral blood lymphocyte surface marker expression. Peripheral blood mononuclear cells (PBMC) were obtained from seven healthy volunteers. Cells were incuba
Mechanisms of protection against rotavirus in humans and mice.: J Infect Dis. 1996 Sep;174 Suppl 1:S51-8. Unique Identifier : AIDSLINE MED/96355042; Ward RL; Division of Infectious Diseases, Children's Hospital Medical; Center, Cincinnati, Ohio, USA.; Immune responses following either natural or experimental rotavirus infection provide protection against subsequent rotavirus illnesses, and the mechanisms involved have been examined in humans and animals. In adult volunteers challenged with human rotaviruses, protection has been shown to correlate with serum and int
[Efficiency of combination chemotherapy and interferon-alpha therapy in a patient with AIDS-related cutaneous and gastrointestinal Kaposi's sarcoma]: Kansenshogaku Zasshi. 1996 Jun;70(6):621-6. Unique Identifier : AIDSLINE MED/96344639; Sawayama Y; Hayashi J; Yano Y; Takeya S; Tani Y; Pei Y; Kashiwagi S; Department of General Medicine, Kyusyu University, Fukuoka,; Japan.; A 40-year-old male was admitted to the hospital with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP). Two months before admission the patient had a high fever, general fatigue and mild epigastic tenderness. On admission, physical examination revealed numerous small tumors on the head
Soft tissue infections of the upper extremities with special consideration of abscesses in parenteral drug abusers. A prospective study.: J Hand Surg [Br]. 1995 Dec;20(6):797-800. Unique Identifier : AIDSLINE MED/96366567; Simmen HP; Giovanoli P; Battaglia H; Wust J; Meyer VE; Department of Surgery, University of Zurich Medical School,; Switzerland.; Despite surgical advances and new antibiotics, upper extremity infections continue to present a serious problem. Soft tissue infections of the upper extremities were prospectively examined to elucidate incidence, cause, bacterial pathogens involved, and treatment. Special attention was paid to infections associated wi
Risk factors for hepatitis C virus infection among blood donors in an HIV-epidemic area in Thailand.: J Epidemiol Community Health. 1996 Apr;50(2):174-7. Unique Identifier : AIDSLINE MED/96306005; Sawanpanyalert P; Boonmar S; Maeda T; Matsuura Y; Miyamura T; Department of Medical Services, Ministry of Public Health,; Nonthaburi, Thailand.; OBJECTIVE: The role of sexual transmission in hepatitis C virus (HCV) infection has not yet been completely elucidated. This study aimed to compare the risk factors for HCV and human immunodeficiency virus (HIV) infection in an HIV epidemic area of Thailand where HIV is mainly tr
Study on occurrence of human calicivirus (Mexico strain) as cause of sporadic cases and outbreaks of calicivirus-associated diarrhoea in the United Kingdom, 1983-1995.: J Med Virol. 1996 Mar;48(3):273-7. Unique Identifier : AIDSLINE MED/96245044; Cubitt WD; Jiang X; Department of Microbiology, Great Ormond Street Hospital for; Children, London, UK.; The use of a recently developed EIA using antisera raised against purified baculovirus expressed recombinant Mexico virus (rMx) capsid protein is described for screening for human calicivirus in stools. The results show that MX-like viruses have been circulating in the UK periodica
Spastic paraparesis and mutations in the prion protein gene [letter]: J Neurol Sci. 1995 Dec;134(1-2):215-6. Unique Identifier : AIDSLINE MED/96341535; Yamada M; Satoh S; Sodeyama N; Fujigasaki H; Kaneko K; Wada Y; Itoh Y; Matsushita M; Department of Neurology, Tokyo Medical and Dental University,; Japan.
Undermining prejudice: the other epidemic [editorial]: J Nurs Educ. 1996 May;35(5):195. Unique Identifier : AIDSLINE MED/96305699; Tanner CA
Inquiry based learning, nursing student attitudes and the HIV patient.: J Nurs Educ. 1996 May;35(5):219-22. Unique Identifier : AIDSLINE MED/96305703; Cerny JE; Amundson MJ; Mueller CW; Waldron JA; Tripler Army Medical Center, School of Nursing, University of; Hawaii, USA.
A critical experiential teaching strategy: student and faculty participation in an AIDS walk.: J Nurs Educ. 1996 May;35(5):223-6. Unique Identifier : AIDSLINE MED/96305704; Patsdaughter CA; Hall JM; Stevens PE; Northeastern University, Boston, Massachusetts, USA.
Intervention to promote safer sexual behaviors and educate peers about HIV/AIDS.: J Nurs Educ. 1996 May;35(5):227-9. Unique Identifier : AIDSLINE MED/96305705; Nokes KM; CUNY, Hunter College, Hunter-Bellevue School of Nursing, New; York, New York, USA.; Sexually active college students are at risk for infection with the Human Immunodeficiency Virus (HIV). Nursing students can learn a variety of desirable professional skills and provide an important service to their college peers by participating in an ongoing intervention to promote safer sexual behaviors. Since 1989
HIV/AIDS nursing care: instrument for measuring students' attitudes and precautions.: J Nurs Educ. 1996 May;35(5):230-3. Unique Identifier : AIDSLINE MED/96305706; Wiley K; Edwards J; Smillie P; Heath L; Acklin M; Department of Psychology, Loyola University, Chicago, Illinois; 60626, USA.
Stigma: baccalaureate nursing students' attitudes toward persons living with AIDS.: J Nurs Educ. 1996 May;35(5):234-6. Unique Identifier : AIDSLINE MED/96305707; Leasure R; Hawkins LA; Merrill A; College of Nursing, University of Oklahoma, Oklahoma City 73190,; USA.
Hazards to the orthopaedic trauma surgeon: occupational exposure to HIV and viral hepatitis (a review article).: J Orthop Trauma. 1996;10(4):289-96. Unique Identifier : AIDSLINE MED/96305719; Chou L; Reynolds MR; Esterhai JL Jr; Department of Physical Medicine and Rehabilitation, University of; Washington School of Medicine, Seattle, USA.; The risk of transmission of blood-borne pathogens is directly related to the prevalence of the infectious disease in the physician s patient population, the infectivity after a single exposure, and the frequency and nature of exposure. After reading this material the reader should understand the guidelines for risk pr
Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations.: J Pharm Sci. 1996 May;85(5):478-85. Unique Identifier : AIDSLINE MED/96311705; Waclawski AP; Sinko PJ; Department of Pharmaceutics, College of Pharmacy, Rutgers, State; University of New Jersey, Piscataway 08855, USA.; The intestinal transport and metabolism of stavudine ( d4T ), a nucleoside analogue of thymidine used in the treatment of AIDS, was studied using single-pass intestinal perfusion (SPIP)
[MRI and CT of parotid diseases in HIV-positive patients]: J Radiol. 1996 Jul;77(7):483-7. Unique Identifier : AIDSLINE MED/96360221; Bindou M; Brun F; Leroux E; Ney D; Staub T; Bourjat P; Service de Radiologie A, Hopital Civil, Strasbourg.; We report five cases of HIV patients with parotid pathology during a period of one year. All patients (4 men and 1 woman between the ages of 32 and 47 years) had a MRI or a CT confirmation of the parotid gland lesion. Three patients exhibited parotid gland cysts, one a nonspecific chronic inflammation and one an enlar
CD4+ T cell inducible immunoregulatory cytokine response in rheumatoid arthritis.: J Rheumatol. 1996 May;23(5):809-14. Unique Identifier : AIDSLINE MED/96315736; al-Janadi N; al-Dalaan A; al-Balla S; Raziuddin S; Department of Medicine, College of Medicine, King Saud; University, Abha, Saudi Arabia.; OBJECTIVE. Monocytes and CD4+/CD8+ T cells produce immunoregulatory cytokines that participate in the pathogenesis of various immune disorders. We investigated the secretion of Th1-Th2 cell response cytokine production of CD4+/CD8+ T cells from the synovial fluid (SF) and blood of patients with rheumatoid arthritis (R
Assessment of left atrial pressure and volume changes during atrial systole with transesophageal pulsed Doppler echocardiography of transmitral and pulmonary venous flow velocities.: Jpn Heart J. 1996 May;37(3):333-42. Unique Identifier : AIDSLINE MED/96370730; Oki T; Kageji Y; Fukuda N; Iuchi A; Tabata T; Manabe K; Yamada H; Fukuda K; Ito S; Second Department of Internal Medicine, Tokushima University; School of Medicine, Japan.; To determine whether transmitral and pulmonary venous flow velocity patterns can be used to evaluate left atrial pressure and volume changes during atrial systole, we performed transesophageal pulsed Doppler echocardiography and right heart catheterization in 85 patients (20 with hypertrophic cardiomyopathy, 20 with d
[Kala-azar in HIV infection: the tip of the iceberg? (editorial)]: Med Clin (Barc). 1996 May 11;106(18):697-9. Unique Identifier : AIDSLINE MED/96265826; Pineda JA; Macias J
[Disseminated histoplasmosis and AIDS. Report of 4 cases]: Med Clin (Barc). 1996 May 11;106(18):700-3. Unique Identifier : AIDSLINE MED/96265827; Bayes B; Romeu J; Vaquero M; Ribera M; Navarro JT; Rosell A; Sirera G; Clotet B; Servicio de Medicina Interna, Hospital Universitario Germans; Trias i Pujol, Badalona, Barcelona.; Disseminated histoplasmosis is frequent in patients with HIV infection from endemic zones of Africa and South America. It is infrequent in Europe. Four cases diagnosed as disseminated histoplasmosis among a total of 1,100 AIDS cases reported from 1984 to 1994 were reviewed. Four males with a mean age of 40 years were
[Hypocalcemia and hypomagnesemia associated with the treatment with pentamidine in 2 patients with HIV infection (letter)]: Med Clin (Barc). 1996 May 11;106(18):717. Unique Identifier : AIDSLINE MED/96265830; Cortes E; Jufresa J; Falco V; Ribera E
[Changes in the spectrum of AIDS-defining diseases in Spain]: Med Clin (Barc). 1996 May 18;106(19):730-3. Unique Identifier : AIDSLINE MED/96265838; Castilla J; Gutierrez A; Noguer I; Centro Nacional de Epidemiologia, Instituto de Salud Carlos III,; Madrid.; BACKGROUND: Since the late 1980s the use of prophylaxis against several AIDS-diagnostic diseases has been recommended. In order to detect the impact of these measures we analyzed the shifts in the spectrum of AIDS-diagnostic diseases in Spain . PATIENTS AND METHODS: AIDS cases (CDC-1
[AIDS and women: is a more effective prevention possible? (editorial)]: Med Clin (Barc). 1996 May 18;106(19):734-6. Unique Identifier : AIDSLINE MED/96265839; Gordillo Alvarez-Valdes MV
[From Samarkand to Tashkent]: Med Clin (Barc). 1996 May 18;106(19):749-50. Unique Identifier : AIDSLINE MED/96265842; Casabona J; Centre d'Estudis Epidemiologics sobre la Sida (CEESCAT),; Universitat Autonoma de Barcelona.
[Disseminated cryptococcosis in a 30-year-old woman with hepatosplenomegaly and without HIV antibodies (clinical conference)]: Med Clin (Barc). 1996 May 25;106(20):787-96. Unique Identifier : AIDSLINE MED/96265854; Richart C; Ribalta T; Catedratico de Medicina, Servicio de Medicina Interna, Hospital; Universitari Joan XXIII, Tarragona.
[:Sidoso: and :sidico:: 2 Spanish adjectives for AIDS (letter)]: Med Clin (Barc). 1996 May 25;106(20):797. Unique Identifier : AIDSLINE MED/96265855; Navarro FA
[Antiretroviral treatment against HIV (letter)]: Med Clin (Barc). 1996 May 25;106(20):798-9. Unique Identifier : AIDSLINE MED/96265856; Pulido F; Rubio R
Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.: Microbiol Rev. 1996 Jun;60(2):386-406. Unique Identifier : AIDSLINE MED/96261761; Chirmule N; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; N_Chirmule or S_Pahwa@CRCVAX.MED.CORNELL.EDU; Infection by human immunodeficiency virus type 1 (HIV-1) leads to progressive destruction of the CD4+ T-cell subset, resulting in immune deficiency and AIDS. The specific binding of the viral external envelope glycoprotein of HIV-1, gp120, to the CD4 molecules initiates viral entry. In the past few years, several stud
Update: vaccine side effects, adverse reactions, contraindications, and precautions. Recommendations of the Advisory Committee on Immunization Practices (ACIP).: MMWR Morb Mortal Wkly Rep. 1996 Sep 6;45(RR-12):1-35. Unique Identifier : AIDSLINE MED/96379651; This report provides updated information concerning the potential adverse events associated with vaccination for hepatitis B, poliomyelitis, measles, mumps, diphtheria, tetanus, and pertussis. This information incorporates findings from a series of recent literature reviews, conducted by an expert committee at the Ins
The Context of HIV Risk Among Drug Users and Their Sexual Partners. Proceedings of a meeting. April 22-23, 1993.: NIDA Res Monogr. 1994;143:1-245. Unique Identifier : AIDSLINE MED/96388910
Drug use and HIV risk among male sex workers: results of two samples in San Francisco.: NIDA Res Monogr. 1994;143:114-31. Unique Identifier : AIDSLINE MED/96296153; Waldorf D; Institute for Scientific Analysis, Alameda, CA 94501, USA.
HIV risk in drug-using adolescents.: NIDA Res Monogr. 1994;143:132-4. Unique Identifier : AIDSLINE MED/96296154; Smeriglio VL; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857, USA.
HIV risk in adolescents: the role of sexual activity and substance use behaviors.: NIDA Res Monogr. 1994;143:135-54. Unique Identifier : AIDSLINE MED/96296155; Boyer CB; Ellen JM; Department of Pediatrics, University of California, San Francisco; 94143-0374, USA.
Going nowhere fast: methamphetamine use and HIV infection.: NIDA Res Monogr. 1994;143:155-82. Unique Identifier : AIDSLINE MED/96296156; Rotheram-Borus MJ; Luna GC; Marotta T; Kelly H; Adolescent Prevention Studies Unit, University of California, Los; Angeles 90024, USA.
Bringing the context in from the cold: substantive, technical, and statistical issues for AIDS research in the second decade.: NIDA Res Monogr. 1994;143:187-201. Unique Identifier : AIDSLINE MED/96296157; Brunswick AF; Columbia University, Public Health/Sociomedical Sciences, New; York 10032, USA.
The context of risk: ethnographic contributions to the study of drug use and HIV.: NIDA Res Monogr. 1994;143:202-17. Unique Identifier : AIDSLINE MED/96296158; Koester SK; Department of Psychiatry, University of Colorado School of; Medicine, Denver 80211, USA.
Assessing the reliability and validity of self-reported risk behavior.: NIDA Res Monogr. 1994;143:218-36. Unique Identifier : AIDSLINE MED/96296159; Gibson DR; Young M; Department of Psychiatry, University of California, San Francisco; 94143, USA.
Future directions for studies on the context of HIV risk.: NIDA Res Monogr. 1994;143:236-45. Unique Identifier : AIDSLINE MED/96296160; Grace WC; Battjes RJ; Sloboda Z; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857, USA.
HIV/AIDS risks among male, heterosexual noninjecting drug users who exchange crack for sex.: NIDA Res Monogr. 1994;143:26-40. Unique Identifier : AIDSLINE MED/96296147; Inciardi JA; Center for Drug and Alcohol Studies, University of Delaware,; Newark 19716-2582, USA.
Context of HIV risk behavior among female injecting drug users and female sexual partners of injecting drug users.: NIDA Res Monogr. 1994;143:41-7. Unique Identifier : AIDSLINE MED/96296148; Hartel D; AIDS Research, Montefiore Hospital, Bronx, NY 10467, USA.
Female drug abusers and the context of their HIV transmission risk behaviors.: NIDA Res Monogr. 1994;143:48-63. Unique Identifier : AIDSLINE MED/96296149; Allen K; Department of Psychiatric, Community Health, and Adult Primary; Care, University of Maryland School of Nursing, Baltimore, MD; 21201-1579, USA.
HIV risk behaviors of heterosexual male drug users.: NIDA Res Monogr. 1994;143:5-8. Unique Identifier : AIDSLINE MED/96296145; Needle RH; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857, USA.
Factors associated with sexual risk of AIDS in women.: NIDA Res Monogr. 1994;143:64-81. Unique Identifier : AIDSLINE MED/96296150; O'Leary A; Department of Psychology, Rutgers University, New Brunswick, NJ; 08903, USA.
Drug use and HIV risk among gay and bisexual men: an overview.: NIDA Res Monogr. 1994;143:82-7. Unique Identifier : AIDSLINE MED/96296151; Battjes RJ; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857, USA.
Substance use and HIV-transmitting behaviors among gay and bisexual men.: NIDA Res Monogr. 1994;143:88-113. Unique Identifier : AIDSLINE MED/96296152; Ostrow DG; Department of Psychiatry and Mental Health Sciences, Medical; College of Wisconsin, Milwaukee 53226, USA.
Injection and sexual risk behaviors of male heterosexual injecting drug users.: NIDA Res Monogr. 1994;143:9-25. Unique Identifier : AIDSLINE MED/96296146; Stephens RC; Alemagno SA; Department of Sociology, University of Akron, OH 44325-0602, USA.
HIV and therapeutic communities.: NIDA Res Monogr. 1994;144:232-58. Unique Identifier : AIDSLINE MED/96296579; McCusker J; Sorensen JL; Department of Clinical Epidemiology and Community Studies, St.; Mary's Hospital Center, Montreal, Canada.
Social Networks, Drug Abuse, and HIV Transmission. Proceedings of a meeting. August 19-20, 1993.: NIDA Res Monogr. 1995;151:1-215. Unique Identifier : AIDSLINE MED/96388912
A comparison of drug use networks across three cities.: NIDA Res Monogr. 1995;151:109-30. Unique Identifier : AIDSLINE MED/96287990; Williams ML; Zhuo Z; Siegal HA; Robles RR; Trotter RT 2nd; Jones A; NOVA Research Company, Bethesda, MD 20814, USA.
Ethical and legal issues in social network research: the real and the ideal.: NIDA Res Monogr. 1995;151:131-43. Unique Identifier : AIDSLINE MED/96287991; Woodhouse DE; Potterat JJ; Rothenberg RB; Darrow WW; Klovdahl AS; Muth SQ; El Paso County Department of Health and Environment, Colorado; Springs, USA.
Network models for HIV outreach and prevention programs for drug users.: NIDA Res Monogr. 1995;151:144-80. Unique Identifier : AIDSLINE MED/96287992; Trotter RT II; Bowen AM; Potter JM Jr; Department of Anthropology, Northern Arizona University,; Flagstaff 86011, USA.
A personal network approach to AIDS prevention: an experimental peer group intervention for street-injecting drug users: the SAFE study.: NIDA Res Monogr. 1995;151:181-95. Unique Identifier : AIDSLINE MED/96287993; Latkin CA; Department of Mental Health, Johns Hopkins University, Baltimore,; MD 21205, USA.
Promising social network research results and suggestions for a research agenda.: NIDA Res Monogr. 1995;151:196-215. Unique Identifier : AIDSLINE MED/96287994; Friedman SR; National Development and Research Institutes, Inc, New York; 10013, USA.
Using dyadic data for a network analysis of HIV infection and risk behaviors among injecting drug users.: NIDA Res Monogr. 1995;151:20-37. Unique Identifier : AIDSLINE MED/96287986; Neaigus A; Friedman SR; Goldstein M; Ildefonso G; Curtis R; Jose B; National Development and Research Institutes, Inc., New York; 10013, USA.
Social networks in disease transmission: the Colorado Springs Study.: NIDA Res Monogr. 1995;151:3-19. Unique Identifier : AIDSLINE MED/96287985; Rothenberg RB; Woodhouse DE; Potterat JJ; Muth SQ; Darrow WW; Klovdahl AS; Department of Family and Preventive Medicine, Emory University; School of Medicine, Atlanta, GA 30303, USA.
Injecting drug use, characteristics of significant others, and HIV-risk behaviors.: NIDA Res Monogr. 1995;151:38-59. Unique Identifier : AIDSLINE MED/96287987; Price RK; Cottler LB; Mager D; Murray KS; Department of Psychiatry, Washington University School of; Medicine, St. Louis, MO 63110, USA.
Sibling homophily in HIV infection: biopsychosocial linkages in an urban African-American sample.: NIDA Res Monogr. 1995;151:60-88. Unique Identifier : AIDSLINE MED/96287988; Brunswick AF; Messeri PA; Dobkin J; Flood MT; Yang A; School of Public Health, Columbia University, New York 10032,; USA.
Focal networks and HIV risk among African-American male intravenous drug users.: NIDA Res Monogr. 1995;151:89-108. Unique Identifier : AIDSLINE MED/96287989; Frey FW; Abrutyn E; Metzger DS; Woody GE; O'Brien CP; Trusiani P; Department of Political Science, University of Pennsylvania,; Philadelphia 19104, USA.
NIH lends a hand with loan repayment.: Nature. 1996 Sep 12;383(6596):197-8. Unique Identifier : AIDSLINE MED/96371054; Gershon D
Occupational transmission of HIV to health care workers [news]: Nurse Pract. 1996 Apr;21(4):129-30. Unique Identifier : AIDSLINE MED/96272453; Klaus BD
Aspergillus fumigatus peptides differentially express Th1 and Th2 cytokines.: Peptides. 1996;17(2):183-90. Unique Identifier : AIDSLINE MED/96255354; Kurup VP; Hari V; Guo J; Murali PS; Resnick A; Krishnan M; Fink JN; Department of Medicine, Medical College of Wisconsin, Milwaukee,; USA.; Relevant allergens from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis (ABPA) have been cloned and expressed. The pathogenesis of ABPA probably depends on specific cytokines and immunoglobulins secreted by lymphocytes on stimulation with different epitopes of those allergens. In the pres
Chemotherapy of human and animal coccidioses: state and perspectives.: Parasitol Res. 1996;82(3):193-9. Unique Identifier : AIDSLINE MED/96252383; Haberkorn A; Institute for Parasitology, Bayer AG, Leverkusen, Germany.; The state and perspectives for chemotherapy of cyst-forming and non-cyst-forming coccidia in humans and animals are summarized. In toxoplasmosis the therapeutic care of transplacental infections, which have gone out of control because of immunodeficiency, is in the forefront of attempts at improvement. Predominant dru
[The number of HIV infections acquired from heterosexual contact]: Pharm Unserer Zeit. 1996 May;25(3):153. Unique Identifier : AIDSLINE MED/96285141
[Expert discussion on subtypes HIV-1: no valid evidence for differences in infectiousness]: Pharm Unserer Zeit. 1996 May;25(3):155. Unique Identifier : AIDSLINE MED/96285143
[Robert Koch Institute information on new AIDS therapies]: Pharm Unserer Zeit. 1996 May;25(3):155. Unique Identifier : AIDSLINE MED/96285142
Effects of UV on HIV and other infections. Introduction.: Photochem Photobiol. 1996 Aug;64(2):231-3. Unique Identifier : AIDSLINE MED/96336921; Beer JZ; Zmudzka BZ; Center for Devices and Radiological Health, Food and Drug; Administration, Rockville, MD 20857, USA. jzb@fdadr.cdrh.fda.gov
Is phototherapy safe for HIV-infected individuals?: Photochem Photobiol. 1996 Aug;64(2):234-7. Unique Identifier : AIDSLINE MED/96336922; Adams ML; Houpt KR; Cruz PD Jr; Department of Dermatology, University of Texas Southwestern; Medical Center, Dallas 75235-9069, USA.; Patients infected with human immunodeficiency virus (HIV) have a high prevalence of UV radiation-responsive skin diseases including psoriasis, pruritus, eosinophilic folliculitis and eczemas. On the other hand, UV has been shown to suppress T cell-mediated immune responses and to induce activation and replication of H
Effect of low-dose gamma radiation of HIV replication in human peripheral blood mononuclear cells.: Photochem Photobiol. 1996 Aug;64(2):238-41. Unique Identifier : AIDSLINE MED/96336923; Xu Y; Conway B; Montaner JS; O'Shaughnessy MV; Greenstock CL; British Columbia Centre for Excellence in HIV/AIDS, Department of; Medicine, Faculty of Medicine, University of British Columbia,; Canada.; Recent studies have demonstrated that UV light and x-irradiation enhance human immunodeficiency virus (HIV) gene expression. There are few published data on related effects of gamma-radiation. This may be of clinical relevance, as radiotherapy has been used extensively for the treatment of acquired immunodeficiency sy
Medical UV exposures and HIV activation.: Photochem Photobiol. 1996 Aug;64(2):246-53. Unique Identifier : AIDSLINE MED/96336925; Zmudzka BZ; Miller SA; Jacobs ME; Beer JZ; Center for Devices and Radiological Health, Food and Drug; Administration, Rockville, MD 20857, USA. BZZ@FDADR.CDRH.FDA.GOV; This paper presents the first attempt to evaluate the potential of clinical UV exposures to induce the human immunodeficiency (HIV) promoter and, thus, to upregulate HIV growth in those skin cells that are directly affected by the exposure. Using the data for HIV promoter activation in vitro, we computed UVB and psora
Does exposure to UV radiation induce a shift to a Th-2-like immune reaction?: Photochem Photobiol. 1996 Aug;64(2):254-8. Unique Identifier : AIDSLINE MED/96336926; Ullrich SE; Department of Immunology, University of Texas, M.D. Anderson; Cancer Center, Houston 77030-4095, USA.; sullrich@notes.mdacc.tmc.edu; In addition to being the primary cause of skin cancer, UV radiation is immune suppressive and there appears to be a link between the ability of UV to suppress the immune response and induce skin cancer. Cytokines made by UV-irradiated keratinocytes play an essential role in activating immune suppression. In particular
PUVA therapy is preferable to UVB phototherapy in the management of HIV-associated dermatoses.: Photochem Photobiol. 1996 Aug;64(2):267-8. Unique Identifier : AIDSLINE MED/96336928; Morison WL; Johns Hopkins University, Baltimore, MD, USA.; Both methoxsalen plus UVA (PUVA) therapy and UVB phototherapy are commonly used in the management of human immunodeficiency virus-associated dermatoses but UVB phototherapy appears to be the preferred treatment. There are several considerations, in particular therapeutic efficacy and therapeutic profile, which suggest
The skin immune system in the course of HIV-1 infection.: Photochem Photobiol. 1996 Aug;64(2):275-9. Unique Identifier : AIDSLINE MED/96336930; Henry M; Tschachler E; Department of Dermatology, University of Vienna Medical School,; Austria. Mike.Henry@akh-wien.ac.at; In human immunodeficiency virus-1 (HIV-1) infection, diseases of the skin and mucous membranes frequently dominate the clinical picture as a consequence of progressive immunodeficiency. Functional impairment of the skin immune system, manifesting as a loss of the skin delayed-type hypersensitivity response is very lik
Signal transduction and HIV transcriptional activation after exposure to ultraviolet light and other DNA-damaging agents.: Photochem Photobiol. 1996 Aug;64(2):280-5. Unique Identifier : AIDSLINE MED/96336931; Valerie K; Laster WS; Cheng L; Kirkham JC; Reavey P; Kuemmere NB; Department of Radiation Oncology, Medical College of Virginia,; Virginia Commonwealth University, Richmond 23298-0058, USA.; kvalerie@gems.vcu.edu; Short wavelength (254 nm) ultraviolet light (UVC) radiation was much more potent in activating transcription of human immunodeficiency virus 1 (HIV) reporter genes stably integrated into the genomes of human and monkey cells than ionizing radiation (IR) from a 137Cs source at similarly cytotoxic doses. A similar diffe
[Diagnostic strategies of pulmonary pneumocystis infection in patients with HIV infection. Decision analysis and medico-economic consequences]: Rev Mal Respir. 1996 Jul;13(3):265-72. Unique Identifier : AIDSLINE MED/96331621; Chouaid C; Housset B; Service de Pneumologie, Hopital Intercommunal de Creteil,; France.; P. carinii pneumonia is one of the most frequent opportunistic infections in HIV-infected patients. Clinical and radiological manifestations are non-specific and reference diagnostic procedure remains broncho-alveolar lavage which is costly and invasive. Alternative diagnostic strategies have been proposed. We report
Current problems with tuberculosis treatment.: Res Microbiol. 1996 Jan-Feb;147(1-2):10-6. Unique Identifier : AIDSLINE MED/96341176; Grosset J; Laboratoire Central de Bacteriologie-Virologie et Hygiene,; Groupe Hospitalier Pitie-Salpetriere, Paris.
Treatment of disseminated Mycobacterium avium complex disease: a clinician's perspective.: Res Microbiol. 1996 Jan-Feb;147(1-2):16-24. Unique Identifier : AIDSLINE MED/96341177; Benson CA; Section of Infectious Disease, Rush University, Chicago, Illinois; 60612, USA.
Solving the dilemma of antimycobacterial chemotherapy.: Res Microbiol. 1996 Jan-Feb;147(1-2):7-10. Unique Identifier : AIDSLINE MED/96341175; Rastogi N; Falkinham JO 3d; Tuberculosis and Mycobacteria Unit, Institut Pasteur de la; Guadeloupe, Pointe-a-Pitre, Guadeloupe, French West Indies.
[Pyomyositis in adults in central Tunisia. Apropos of 10 cases]: Rev Med Interne. 1996;17(4):300-4. Unique Identifier : AIDSLINE MED/96340906; Chekir T; Omezzine Letaief A; Bahri F; Jamel A; Aloui S; Jemni L; Service de rhumatologie, CHU Farhat Hached, Sousse, Tunisie.; Ten adult patients treated for pyomyositis between 1988 and 1994 in Sousse s university hospital ( Tunisia ) were retrospectively reviewed. Due to the non specific symptoms, the diagnosis was often delayed (mean = 17 days) and other primary diagnoses were considered, mainly includin
[Immunopathological mechanisms of human immunodeficiency virus infection]: Rev Med Interne. 1996;17(4):313-20. Unique Identifier : AIDSLINE MED/96340908; Gluckman JC; Laboratoire d'immunologie cellulaire de l'ecole pratique des; hautes etudes, hopital de la Pitie-Salpetriere, Paris,; France.; Human immunodeficiency virus (HIV) infection usually elicits an early, strong and efficient immune response, despite which the virus can persist in the organism by using a complex strategy. It escapes immune surveillance through direct and indirect effects on cells of the immune system; by modifying its biological pro
Using a mixture model to predict the occurrence of diabetic retinopathy.: Stat Med. 1995 Dec 15;14(23):2599-608. Unique Identifier : AIDSLINE MED/96363661; Young P; Morgan B; Sonksen P; Till S; Williams C; Department of Applied Statistics, University of Reading, U.K.; Diabetes mellitus is a common condition which has several serious complications associated with it. In this paper a mixture model, based on one previously used to predict the onset of AIDS, is used to predict the onset of one of these complications, diabetic retinopathy, the major cause of adult blindness in the U.K.
NCI: a lab scientist's view, from the director's office [interview]: Science. 1996 Sep 6;273(5280):1329-30. Unique Identifier : AIDSLINE MED/96386418; Klausner R
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex.: Science. 1996 Sep 13;273(5281):1547-51. Unique Identifier : AIDSLINE MED/96365225; Battiste JL; Mao H; Rao NS; Tan R; Muhandiram DR; Kay LE; Frankel AD; Williamson JR; Department of Chemistry, Massachusetts Institute of Technology,; Cambridge, MA 02139, USA.; The solution structure of a human immunodeficiency virus type-1 (HIV-1) Rev peptide bound to stem-loop IIB of the Rev response element (RRE) RNA was solved by nuclear magnetic resonance spectroscopy. The Rev peptide has an alpha-helical conformation and binds in the major groove of the RNA near a purine-rich internal
The relevance of social network concepts to sexually transmitted disease control.: Sex Transm Dis. 1996 Jan-Feb;23(1):24-9. Unique Identifier : AIDSLINE MED/96271618; Rothenberg R; Narramore J; Department of Family and Preventive Medicine, Emory University; School of Medicine, Atlanta, Georgia 30303, USA.; Many of the concepts of social network analysis have been tacit assumptions of sexually transmitted disease control efforts for decades. With the advent of AIDS in the 1980s, an overt rapprochement between these two fields--previously separated by culture, context, and language--was made. Social network constructs hav
Strategies for syphilis prevention in the 1990s.: Sex Transm Dis. 1996 Jan-Feb;23(1):58-67. Unique Identifier : AIDSLINE MED/96271623; St Louis ME; Division of STD Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; Reconfiguring and refocusing syphilis control and prevention programs in the United States is required by the changing epidemiology and sociology of syphilis as well as by the importance and magnitude of human immunodeficiency virus (HIV) prevention efforts. An updated strategic approa
Long-term survival of rat to mouse cardiac xenografts with prolonged blockade of CD28-B7 interaction combined with peritransplant T-cell depletion.: Surgery. 1996 Aug;120(2):205-12. Unique Identifier : AIDSLINE MED/96350343; Rehman A; Tu Y; Arima T; Linsley PS; Flye MW; Department of Surgery, Washington University School of Medicine,; St. Louis, Mo. USA.; BACKGROUND: The hCTLA4Ig/mCTLA4Ig fusion protein of the extracellular domain of human/mouse CTLA4 and the Fc portion of the human/mouse immunoglobulin G1 block the CD28/B7 costimulatory T-cell activation pathway. We evaluated the effect of prolonged B7-CD28 blockade, T-cell depletion, or both on rat to mouse cardiac x
Transfusion and cytomegalovirus-associated AIDS-defining disease in hemophiliacs. Hemophilia Malignancy Study.: Transfusion. 1996 Aug;36(8):681-4. Unique Identifier : AIDSLINE MED/96374370; Ragni MV; Triulzi DJ; Bass D; Duerstein S; University of Pittsburgh School of Medicine, Hemophilia Center of; Western Pennsylvania, USA.; BACKGROUND: Whether transfusion increases the risk of AIDS-defining cytomegalovirus ( CMV ) infection (CMV AIDS) in immunosuppressed patients is not known. Because of concerns about the risk of transfusion transmission of CMV a
Absence of human immunodeficiency virus type 2 infection among patients in a hospital serving a New York community at high risk for infection. Centers for Disease Control and Prevention/Bronx-Lebanon Hospital Center HIV Serosurvey Team.: Transfusion. 1996 Aug;36(8):731-3. Unique Identifier : AIDSLINE MED/96374378; Irwin KL; Olivo N; Schable C; Weber JT; Janssen R; Ernst J; Centers for Disease Control and Prevention, Atlanta, Georgia,; USA.; BACKGROUND: Although human immunodeficiency virus type 2 (HIV-2) infection among United States residents is considered rare, there are US populations at high risk. Few studies have surveyed these populations with a high likelihood of infection, that is, those with high percentages of p
Quantitation of passively acquired human immunodeficiency virus (HIV) antibodies in AIDS patients transfused with a plasma that is rich in HIV antibodies.: Transfusion. 1996 Aug;36(8):734-8. Unique Identifier : AIDSLINE MED/96374379; Lefrere JJ; Roudot-Thoraval F; Vittecoq D; Heshmati F; Audat F; Lerable J; Reed D; Petit JC; Burghoffer B; Morand-Joubert L; Institut National de Transfusion Sanguine, Hopital Cochin,; Paris, France.; BACKGROUND: Passive immunotherapy in human immunodeficiency virus (HIV) infection is based on transfusions of plasma that is rich in HIV antibodies. STUDY DESIGN AND METHODS: To verify whether the clearance of transfused antibodies will maintain an elevated titer of specific antibodies between biweekly transfusions of
Inactivation by phthalocyanine photosensitization of multiple forms of human immunodeficiency virus in red cell concentrates.: Transfusion. 1996 Aug;36(8):743-50. Unique Identifier : AIDSLINE MED/96374381; Margolis-Nunno H; Ben-Hur E; Gottlieb P; Robinson R; Oetjen J; Horowitz B; New York Blood Center, New York, USA.; BACKGROUND: The use of phthalocyanines in conjunction with red light has been shown to inactivate model lipid-enveloped viruses in red cell concentrates. The ability of this treatment to inactivate multiple forms of human immunodeficiency virus (HIV) was evaluated in this study. STUDY DESIGN AND METHODS: The phthalocy
Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection.: Transplantation. 1996 Jul 27;62(2):229-38. Unique Identifier : AIDSLINE MED/96347603; VanBuskirk AM; Wakely ME; Orosz CG; Department of Surgery, The Ohio State University College of; Medicine, Columbus, USA.; It has been hypothesized that TH1 cells mediate the archetypical cell-mediated immune response of acute allograft rejection, whereas TH2 cells promote allograft acceptance. To test this, we transfused SCID cardiac allograft recipients with polarized TH1-like or TH2-like graft-reactive T cells, and monitored graft func
Neoplasia: an example of plasticity of the immune response.: Transplant Proc. 1996 Aug;28(4):2089-93. Unique Identifier : AIDSLINE MED/96357237; Penn I; Department of Surgery, University of Cincinnati Medical Center,; OH 45267-0558, USA.
Apoptosis and CD4+ lymphocyte depletion following feline immunodeficiency virus infection of a T-lymphocyte cell line.: Vet Pathol. 1996 Mar;33(2):195-203. Unique Identifier : AIDSLINE MED/96272105; Johnson CM; Benson NA; Papadi GP; Department of Pathobiology, College of Veterinary Medicine,; University of Florida, Gainesville, USA.; An interleukin-2-dependent feline T-lymphocyte cell line (FCD4-D), of which 65% of cells express CD4, was inoculated with the NCSU-1 isolate of feline immunodeficiency virus (FIV(NCSU-1)) and subsequently monitored for percentage of viable cells, percentage of apoptotic cells, percentage of CD4-expressing cells, and v
[The combination of secondary recurrent syphilis and HIV infection]: Voen Med Zh. 1996 Apr;317(4):35-6, 79. Unique Identifier : AIDSLINE MED/96316736; Naidenov IuN; Lytsar' BN; Skvortsov SV; Komaristov IA; Kashirin IA; Frolova LI; Rodkina GN; Iarkova VV; HIV infection in connection with other venereal diseases change greatly there clinic development. Authors discuss comprehensively the peculiarities of infectious process in case of syphilis connection with HIV-infection, and in particular face syphilid, which is met little in practice of venereologists. Syndrome of ag
New strip immunoblot for the confirmation of HTLV-I/II infection.: Vox Sang. 1996;70(2):114-6. Unique Identifier : AIDSLINE MED/96243529; Vrielink H; Zaaijer HL; Van der Poel CL; Quan S; Cuypers HT; Rios M; Lelie PN; Polito A; Sra K; DiNello R; Pichuantes S; Larson D; Reesink HW; Red Cross Blood Bank Amsterdam, The Netherlands.; In The Netherlands , anti-human T-cell lymphotropic virus type I (HTLV-I) blood donor screening became mandatory in January 1993. Donations reactive in the enzymelinked immunosorbent assay (ELISA) screening test are confirmed with Western blot analysis (WB). Only WB-positive or
Reliability of a screening assay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II [letter]: Vox Sang. 1996;70(2):119-20. Unique Identifier : AIDSLINE MED/96243532; Gomez-Hernando C; Gutierrez M; Toro C; Soriano V
High rate of indeterminate reactivity to HTLV in western blot analysis of Spanish blood donors [letter]: Vox Sang. 1996;70(2):120-1. Unique Identifier : AIDSLINE MED/96243534; Soriano V; Gutierrez M; Aguilera O; de la Rua A; Gonzalez-Lahoz J
Detection of an HTLV-II-seropositive blood donor in Japan [letter]: Vox Sang. 1996;70(2):121-2. Unique Identifier : AIDSLINE MED/96243533; Yoshizaki H; Hall WW; Fukushima Y; Oki A; Yamanaka S; Kitamura K; Yamazaki S; Honda M
Why prescribe highly purified factor VIII and IX concentrates?: Vox Sang. 1996;70(2):61-8. Unique Identifier : AIDSLINE MED/96243521; Berntorp E; Department for Coagulation Disorders, Malmo University Hospital,; Sweden.; The aftermath of the HIV catastrophe and hepatitis virus transmission to hemophiliacs has been characterized by continuous efforts to improve the purity of factor VIII and factor IX concentrates, increasing sophistication of the virucidal methods used, and the introduction of recombinant factor VIII. The cost of hemop
CD8+ lymphocyte decrease in HIV disease: association with anti-CD4+ but not with anti-CD8+ lymphocyte autoantibodies.: Vox Sang. 1996;70(2):86-91. Unique Identifier : AIDSLINE MED/96243524; Daniel V; Susal C; Weimer R; Zipperle S; Kropelin M; Zimmermann R; Huth-Kuhne A; Gerhard I; Maier H; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, Germany.; HIV+ patients form autoantibodies against CD4+ and CD8+ lymphocytes. It was shown that anti-CD4+ lymphocyte autoantibodies are associated with the depletion of CD4+ cells. In the present study we analyzed the relationship of anti-CD4+ and anti-CD8+ autoantibodies with the CD8+ lymphocyte decrease commonly observed dur
Evaluation of subunit vaccines against feline immunodeficiency virus infection.: Vaccine. 1996 Mar;14(4):285-9. Unique Identifier : AIDSLINE MED/96300637; Verschoor EJ; Willemse MJ; Stam JG; van Vliet AL; Pouwels H; Chalmers SK; Horzinek MC; Sondermeijer PJ; Hesselink W; de Ronde A; Virology Unit, Institute of Infectious Diseases and Immunology,; Veterinary Faculty, University Utrecht, The Netherlands.; Subunit vaccines prepared against feline immunodeficiency virus (FIV) infection were evaluated in two trials. First, cats were immunized with bacterial expression products of an envelope fragment that contained the V3 neutralization domain of the FIV surface protein fused to either galactokinase (K-SU3) or glutathione
Induction of homologous virus neutralizing antibodies in guinea-pigs immunized with two human immunodeficiency virus type 1 glycoprotein gp120-iscom preparations. A comparison with other adjuvant systems.: Vaccine. 1996 Mar;14(4):344-52. Unique Identifier : AIDSLINE MED/96300646; Sjolander S; Hansen JE; Lovgren-Bengtsson K; Akerblom L; Morein B; Swedish University of Agricultural Sciences, College of; Veterinary Medicine, Department of Veterinary Microbiology,; Uppsala, Sweden.; The immunogenicity in guinea-pigs of the human immunodeficiency virus type 1 envelope glycoprotein gp120 in immune stimulating complex (iscom) was compared to that of gp120 adjuvanted with QuilA-matrix (iscom without attached antigen), aluminium hydroxide (alum) and the Ribi adjuvant system. Gp120 was either incorpora
HIV-1 candidate vaccines can induce antibodies which share specificity with human monoclonal antibodies capable of neutralizing primary isolates [letter]: Vaccine. 1996 Mar;14(4):353-4. Unique Identifier : AIDSLINE MED/96300647; Davis D
Lung abscess due to nontyphoid Salmonella in an immunocompromised host. Case report with review of the literature.: Acta Clin Belg. 1996;51(3):175-83. Unique Identifier : AIDSLINE MED/96344479; Ridha AG; Malbrain ML; Mareels J; Verbraeken H; Zachee P; Department of Internal Medicine, Algemeen Ziekenhuis Stuivenberg,; Antwerpen, Belgium.; Lung abscess due to nontyphoid Salmonella (NTS) with or without other intestinal or extra-intestinal involvement is very rare. A literature review (Medline search) revealed only 20 cases including ours with this extra-intestinal manifestation of Salmonella infection. The case of a 49-year-old, HIV-positive man from
Invasive fungal sinusitis in immunosuppressed patients. Report of three cases.: Acta Otorhinolaryngol Belg. 1996;50(2):137-42. Unique Identifier : AIDSLINE MED/96337414; Zapater E; Armengot M; Campos A; Montalt J; Pedro F; Basterra J; Department of ENT, University General Hospital, Valencia, Spain.; Report of three cases. Newly appeared immunosuppression related conditions have led to an increase in morbidity of systemic opportunistic mycoses. Rhinosinusal infection has also increased in frequency. Three invasive nasosinusal mycoses are presented: two cases of mucormycosis and a simultaneous infection by mucormyc
Can Dupuytren's contracture be work-related?: review of the evidence.: Am J Ind Med. 1996 May;29(5):521-32. Unique Identifier : AIDSLINE MED/96311331; Liss GM; Stock SR; Health and Safety Studies Unit, Ontario Ministry of Labour,; Toronto, Canada.; Dupuytren s contracture (DC) is a disease of the palmar fascia resulting in thickening and contracture of fibrous bands on the palmar surface of the hands and fingers. For decades, a controversy has existed regarding whether acute traumatic injury or cumulative biomechanical work exposure can contribute to the develop
Seroprevalence survey of Egyptian tourism workers for hepatitis B virus, hepatitis C virus, human immunodeficiency virus, and Treponema pallidum infections: association of hepatitis C virus infections with specific regions of Egypt.: Am J Trop Med Hyg. 1996 Aug;55(2):179-84. Unique Identifier : AIDSLINE MED/96374166; el-Sayed NM; Gomatos PJ; Rodier GR; Wierzba TF; Darwish A; Khashaba S; Arthur RR; Ministry of Health, Cairo, Egypt.; Blood samples from 740 Egyptian Nationals working in the tourism industry at two sites in the South Sinai governorate were screened for markers of infection with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Treponema pallidum. Study subjects included 467 individuals from a
Alcohol use and T-lymphocyte subsets among injection drug users with HIV-1 infection: a prospective analysis.: Alcohol Clin Exp Res. 1996 Apr;20(2):364-71. Unique Identifier : AIDSLINE MED/96279897; Crum RM; Galai N; Cohn S; Celentano DD; Vlahov D; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland, USA.; OBJECTIVES: Alcohol use is known to alter immune function and has immunosuppressive effects that may modify T-lymphocyte subpopulations. However, there is no clear evidence regarding the relationship of alcohol use with the progression of immunodeficiency in human immunodeficiency virus-type 1 (HIV-1)-seropositive ind
Spontaneous pneumothorax in the AIDS population.: Am Surg. 1996 Sep;62(9):753-6. Unique Identifier : AIDSLINE MED/96350158; Spivak H; Keller S; Department of Surgery, Beth Israel Medical Center, New York, New; York, USA.; Spontaneous pneumothorax (SP) in patients with acquired immunodeficiency syndrome (AIDS) has become the leading cause of nontraumatic pneumothorax in the urban population. However, the appropriate treatment, especially the role of surgical intervention, remains controversial. A retrospective study of 33 patients with
beta 2-Microglobulin and CD4/CD8 ratio as HIV-1 markers of maternal transmissibility, neonatal infection and disease progression.: Ann Trop Paediatr. 1996 Jun;16(2):155-60. Unique Identifier : AIDSLINE MED/96382816; Moodley D; Coovadia HM; Bobat RA; Department of Paediatrics and Child Health, Faculty of Medicine,; University of Natal, Durban, South Africa.; A hospital-based cohort study assessing the function of surrogate markers (beta 2-microglobulin and CD4/CD8 ratio) in predicting maternal HIV transmissibility and disease progression in infants was conducted in 110 seropositive black South African mother-infant pairs. There were no differences in beta 2-microglobulin
D4T nucleoside combinations for HIV.: Antiviral Res. 1996 Jan;29(1):101-4. Unique Identifier : AIDSLINE MED/96283749; Pollard RB; University of Texas Medical Branch at Galveston 77555-0882, USA.
Consensus symposium on combined antiviral therapy; overview of interferon and IL-2 combinations for the treatment of HIV infection.: Antiviral Res. 1996 Jan;29(1):105-9. Unique Identifier : AIDSLINE MED/96283750; Sneller MC; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Among the immunomodulatory cytokines that have been evaluated for the treatment of HIV disease, alpha-interferon and interleukin-2 ( IL-2 ) have been the most extensively studied. Monotherapy with alpha-interferon is effective therapy for HIV-associated Kaposi s sarcoma
Pilot clinical trial of the combination of hydroxyurea and didanosine in HIV-1 infected individuals.: Antiviral Res. 1996 Jan;29(1):111-3. Unique Identifier : AIDSLINE MED/96283751; Biron F; Lucht F; Peyramond D; Fresard A; Vallet T; Nugier F; Grange J; Malley S; Hamedi-Sangsari F; Vila J; Service des Maladies Infectieuses et Tropicales, Hopital de la; Croix Rousse, Lyon, France.
Innovative combination clinical trial designs/patient compliance: a community perspective.: Antiviral Res. 1996 Jan;29(1):115-7. Unique Identifier : AIDSLINE MED/96283752; Bahlman W; ACT UP/New York, Treatment and Data, New York, USA.
Inter-company collaboration for AIDS Drug Development: perspective on combination studies.: Antiviral Res. 1996 Jan;29(1):119-22. Unique Identifier : AIDSLINE MED/96283753; McLaren C; Elkins M; Salgo M; Myers M; Benoit S; Warburg M; Bristol-Myers Squibb Pharmaceutical Research Institute,; Department 102, Wallingford, CT 06492, USA.
The implications of drug resistance for strategies of combination antiviral chemotherapy.: Antiviral Res. 1996 Jan;29(1):31-3. Unique Identifier : AIDSLINE MED/96283731; Richman DD; San Diego Veterans Affairs Medical Center, CA, USA.; drichman@ucsd.edu
Combination therapy for HIV-1 infection-overview: preclinical and clinical analysis of antiretroviral combinations.: Antiviral Res. 1996 Jan;29(1):35-9. Unique Identifier : AIDSLINE MED/96283732; Johnson VA; Departments of Medicine and Microbiology, University of Alabama; at Birmingham, USA.
In vitro antiviral activity of 141W94 (VX-478) in combination with other antiretroviral agents.: Antiviral Res. 1996 Jan;29(1):53-6. Unique Identifier : AIDSLINE MED/96283736; St. Clair MH; Millard J; Rooney J; Tisdale M; Parry N; Sadler BM; Blum MR; Painter G; Division of Virology, Glaxo Wellcome Inc., NC 27709, USA.; 141W94 (VX-478) is a novel HIV-1 protease inhibitor with an IC50 of 0.08 microM against HIV-1 (strain IIIB) and a mean IC50 of 0.012 microM against six HIV clinical isolates. 141W94 was synergistic on the basis of isobologram analysis with each of the following reverse transcriptase inhibitors:
Role of animal models in selecting antiviral combinations for clinical studies.: Antiviral Res. 1996 Jan;29(1):57-9. Unique Identifier : AIDSLINE MED/96283737; Kern ER; Department of Pediatrics, University of Alabama at Birmingham; 35294-2170, USA.; Although experimental viral infections in animals have been used extensively in the development of antiviral drugs used as monotherapy, they have not been utilized widely for evaluation of combination chemotherapy. One of the major reasons for the lack of use of animal models is that for the diseases that are the main
Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.: Antiviral Res. 1996 Jan;29(1):69-71. Unique Identifier : AIDSLINE MED/96283741; Jabs DA; Johns Hopkins University School of Medicine, Baltimore, MD 21212,; USA.; The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) high-dose ganciclovir, and (3) combination foscarnet and ganciclovir. Two hun
CMV retinitis: ganciclovir/monoclonal antibody.: Antiviral Res. 1996 Jan;29(1):73-5. Unique Identifier : AIDSLINE MED/96283742; Pollard RB; University of Texas Medical Branch, Galveston 77555-0882, USA.
Cartesian coordinate analysis of viral burden and CD4+ cell count in HIV disease: implications for clinical trial design and analysis.: Antiviral Res. 1996 Jan;29(1):83-6. Unique Identifier : AIDSLINE MED/96283744; Reichelderfer PS; Coombs RW; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD, USA.; HIV-1 infection represents a dynamic interaction between the rapid turnover of virus, CD4+ cell proliferation and clearance. HIV-1 disease progression is assessed, in part, by the inverse relationship between virus burden and CD4+ cell count. However, there is enormous individual subject variability between virus burd
Combination therapy in primary HIV infection.: Antiviral Res. 1996 Jan;29(1):87-9. Unique Identifier : AIDSLINE MED/96283745; Perrin L; Hirschel B; Laboratory of Virology and AIDS Center, Geneva University; Hospital, Switzerland.
Saquinavir/zidovudine combination in patients with advanced HIV infection and no prior antiretroviral therapy: CD4+ lymphocyte/plasma RNA changes, and emergence of HIV strains with reduced phenotypic sensitivity.: Antiviral Res. 1996 Jan;29(1):91-3. Unique Identifier : AIDSLINE MED/96283746; Vella S; Galluzzo C; Giannini G; Pirillo MF; Duncan I; Jacobsen H; Andreoni M; Sarmati L; Ercoli L; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
Reduced sensitivity to saquinavir: an update on genotyping from phase I/II trials.: Antiviral Res. 1996 Jan;29(1):95-7. Unique Identifier : AIDSLINE MED/96283747; Jacobsen H; Haenggi M; Ott M; Duncan IB; Andreoni M; Vella S; Mous J; PRP/Genetechnology, F. Hoffmann-LaRoche AG, PRP/Genetechnology,; Basel, Switzerland.; A genotypic analysis of the HIV-1 proteinase was performed on clinical specimen obtained from patients after different periods of Saquinavir (SQV) treatment. Proteinase genes of integrated proviral DNA from PBMC were isolated by PCR, cloned and individual sequences were obtained. Genotypic resistance was defined by th
Combination therapy with zidovudine, didanosine and saquinavir.: Antiviral Res. 1996 Jan;29(1):99. Unique Identifier : AIDSLINE MED/96283748; Collier AC; Coombs RW; Schoenfeld DA; Bassett R; Baruch A; Corey L; AIDS Clinical Trials Group Protocol 229 Team, NIAID, Bethesda,; MD, USA.; The goal of AIDS Clinical Trials Group (ACTG) Protocol 229 was to evaluate the shorter term (24 week) and longer term (48 week) safety and activity of the HIV-1 proteinase inhibitor saquinavir in combination with zalcitabine ( ddC ) and zidovudine (ZDV)
[Molecular epidemiology of HTLV-I and HTLV-II retroviruses]: Arch Inst Pasteur Tunis. 1994 Jul-Oct;71(3-4):387-95. Unique Identifier : AIDSLINE MED/96238198; de The G; Unite d'Epidemiologie des Virus Oncogenes Institut Pasteur,; Paris.
[The role of Epstein-Barr virus in the development of visceral leishmaniasis]: Arch Inst Pasteur Tunis. 1994 Jul-Oct;71(3-4):453-7. Unique Identifier : AIDSLINE MED/96238206; Louzir H; Laboratoire d'Immunologie, Institut Pasteur de Tunis.
[Hereditary immune deficiency in Tunisia]: Arch Inst Pasteur Tunis. 1994 Jul-Oct;71(3-4):465-7. Unique Identifier : AIDSLINE MED/96238209; Barbouche MR; Bejaoui M; Largueche B; Sassi A; Bouguerra A; Lakhoua R; Dellagi K; Laboratoire d'Immunologie Cellulaire et d'Etude des Deficits; Immunitaires Heriditaires, Hopital Charles Nicolle, Tunis.
[The production of IL-10 in HIV-positive patients with lymphoma]: Arch Inst Pasteur Tunis. 1994 Jul-Oct;71(3-4):529-33. Unique Identifier : AIDSLINE MED/96238214; Edelman L; Rapahael M; Emilie D; Monchatre E; Joab I; Galanaud P; Laboratoire d'Immuno-hematologie et d'Immuno-pathologie,; Institut Pasteur, Paris.
Cell-mediated infection of cervix derived epithelial cells with primary isolates of human immunodeficiency virus.: Arch Virol. 1996;141(7):1177-89. Unique Identifier : AIDSLINE MED/96370784; Tan X; Phillips DM; Population Council, New York, USA.; We have previously demonstrated that HIV-infected transformed T-cells or monocytes adhere to monolayers of CD4-negative epithelial cells. Adhesion is soon followed by budding of HIV from infected mononuclear cells onto the surface of epithelial cells. Epithelial cells subsequently take up virus and become productively
Population and women's reproductive health: an international perspective.: Annu Rev Public Health. 1996;17:359-82. Unique Identifier : AIDSLINE MED/96316113; Miller K; Rosenfield A; Columbia University School of Public Health, New York, NY 10032,; USA.; This paper gives a brief overview of current world population or demographic issues, followed by a discussion of the ICPD proceedings and various notable aspects of the ICPD Programme of Action. It then focuses on six of the most pressing reproductive health concerns facing women today: gender inequalities, access to
Economic evaluation of HIV prevention programs.: Annu Rev Public Health. 1996;17:467-88. Unique Identifier : AIDSLINE MED/96316117; Holtgrave DR; Qualls NL; Graham JD; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53202, USA.; Program managers and policy makers need to balance the costs and benefits of various interventions when planning and evaluating HIV prevention programs. Resources to fund these programs are limited and must be used judiciously to maximize the number of HIV infections averted. Economic evaluation studies of HIV prevent
Sexual hazards for migrant workers.: World Health Forum. 1996;17(3):283-5. Unique Identifier : AIDSLINE MED/96349946; Ford NJ; Kittisuksathit S; Department of Geography and the Institute of Population Studies,; University of Exeter, England.; In Thailand the incidence of HIV/AIDS, other sexually transmitted diseases, and unwanted pregnancies highlights the vulnerability of young people who have moved from rural to urban areas as migrant workers. Possible ways of diminishing the risks are discussed below.
Suicide attempted by burning: a 10-year study of self-immolation deaths.: Burns. 1995 Dec;21(8):607-9. Unique Identifier : AIDSLINE MED/96350800; Castellani G; Beghini D; Barisoni D; Marigo M; Institute of Forensic Medicine, University of Verona, Italy.; In a 10-year retrospective survey of 699 admissions to the Burns Centre of Verona, 31 patients (4.4 per cent) had self-inflicted burns. No sex difference was found, the mean age was 38 years, with 58 per cent of the patients in the 20-39-year age group. The mean burned surface area (BSA) was 41 per cent, and 12 patien
Virological and immunological analysis of a triple combination pilot study with loviride, lamivudine and zidovudine in HIV-1-infected patients.: AIDS. 1996 May;10(5):F1-7. Unique Identifier : AIDSLINE MED/96314090; Staszewski S; Miller V; Rehmet S; Stark T; De Cree J; De Brabander M; Peeters M; Andries K; Moeremans M; De Raeymaeker M; Pearce G; Van den Broeck R; Verbiest W; Stoffels P; Johann Wolfgang Goethe University, Frankfurt, Germany.; OBJECTIVE: To compare two antiretroviral regiments, loviride plus lamivudine ( 3TC ) plus zidovudine (ZDV) (triple combination) and loviride plus ZDV (double combination) in terms of pharmacokinetic interactions, tolerability, safety, and immunological
Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein.: AIDS. 1996 May;10(5):455-61. Unique Identifier : AIDSLINE MED/96314091; Ramazzotti E; Vignoli M; Re MC; Furlini G; La Placa M; Institute of Microbiology, University of Bologna, St Orsola; General Hospital, Italy.; OBJECTIVE: An enhanced nuclear factor (NF)-kappa B activation in response to tumour necrosis factor (TNF)-alpha has been observed in stably tat-transfected cells. Recent experimental evidence suggests that Tat may autocrinously influence both cellular physiology and HIV-1 long terminal repeat-directed gene expression
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.: AIDS. 1996 May;10(5):463-8. Unique Identifier : AIDSLINE MED/96314092; Pittaluga A; Pattarini R; Severi P; Raiteri M; Istituto di Farmacologia e Farmacognosia, University of Genoa,; Italy.; OBJECTIVE: To investigate the effect of HIV-1 gp120 on the function of glutamate receptors of the N-methyl-D-aspartate (NMDA) type in the human brain. DESIGN: The monitoring of neurotransmitter release from superfused isolated nerve endings is widely recognized as a technique appropriate for the study of neurotransmit
Pentoxifylline inhibits acute HIV-1 replication in human T cells by a mechanism not involving inhibition of tumour necrosis factor synthesis or nuclear factor-kappa B activation.: AIDS. 1996 May;10(5):469-75. Unique Identifier : AIDSLINE MED/96314093; Navarro J; Punzon MC; Pizarro A; Fernandez-Cruz E; Fresno M; Munoz-Fernandez MA; Department of Immunology, Gregorio Maranon Universitary; Hospital, Universidad Autonoma de Madrid, Spain.; OBJECTIVE AND DESIGN: To study the in vitro activity of pentoxifylline (PTX), which may be of benefit in AIDS, on cell proliferation, tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma (a type 1 cytokine) and interleukin (IL)-10 (a type 2 cytokine) production, viral replication and CD4+ depletion in acutely HI
Inhibition of fungicidal activity of polymorphonuclear leukocytes from HIV-infected patients by interleukin (IL)-4 and IL-10.: AIDS. 1996 May;10(5):477-83. Unique Identifier : AIDSLINE MED/96314094; Tascini C; Baldelli F; Monari C; Retini C; Pietrella D; Francisci D; Bistoni F; Vecchiarelli A; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; OBJECTIVE: To investigate the effect of human recombinant interleukin (hrIL)-4 or hrIL-10 on the functional status of polymorphonuclear leukocytes (PMNL) from normal subjects and HIV-infected patients. DESIGN: In an in vitro system we studied the effect of hrIL-4 or hrIL-10 on phagocytosis, fungicidal activity and sup
A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).: AIDS. 1996 May;10(5):485-92. Unique Identifier : AIDSLINE MED/96314095; Stein DS; Fish DG; Bilello JA; Preston SL; Martineau GL; Drusano GL; Albany Medical College, Clinical Pharmacology Studies Unit, NY; 12208, USA.; OBJECTIVE: To investigate the safety, pharmacokinetics, and activity of the orally bio-available protease inhibitor MK-639. DESIGN: An open-label Phase I/II trial of medically stable subjects with screening CD4 lymphocyte counts or = 20,000 HIV RNA copies/ml. Pharmacokinetics were performed
Influence of risk group and zidovudine therapy on the development of HIV encephalitis and cognitive impairment in AIDS patients.: AIDS. 1996 May;10(5):493-9. Unique Identifier : AIDSLINE MED/96314096; Bell JE; Donaldson YK; Lowrie S; McKenzie CA; Elton RA; Chiswick A; Brettle RP; Ironside JW; Simmonds P; Department of Pathology, University of Edinburgh, UK.; Objective: To determine the associations between HIV encephalitis and other central nervous system (CNS) pathology, viral burden, cognitive impairment, zidovudine therapy and risk group in AIDS patients. DESIGN: Planned autopsy study in AIDS patients evaluated prospectively for numerous clinical parameters. SETTING: R
Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency.: AIDS. 1996 May;10(5):501-7. Unique Identifier : AIDSLINE MED/96314097; Pirmohamed M; Williams D; Tingle MD; Barry M; Khoo SH; O'Mahony C; Wilkins EG; Breckenridge AM; Park BK; Department of Pharmacology and Therapeutics, University of; Liverpool, UK.; OBJECTIVE: To determine whether HIV-infected patients have a deficiency of intracellular glutathione (GSH) in peripheral blood mononuclear cells (PBMC) and erythrocytes. DESIGN: Initial experiments determining the stability of intracellular GSH preceded the measurement of GSH levels in 33 HIV-positive patients and 40
Reasons for failure of prevention of Toxoplasma encephalitis. Swiss HIV Cohort Study.: AIDS. 1996 May;10(5):509-13. Unique Identifier : AIDSLINE MED/96314098; Van Delden C; Gabriel V; Sudre P; Flepp M; von Overbeck J; Hirschel B; Division of Infectious Diseases, University Hospitals of Geneva,; Switzerland.; OBJECTIVE: To study whether absence of prophylaxis is a risk factor for cerebral toxoplasmosis, and to determine the reasons for absence of prophylaxis among AIDS patients diagnosed with Toxoplasma encephalitis (TE). DESIGN: Retrospective chart review and matched case-control study. PATIENTS: Patients (104 first episo
Randomized cross-over comparison of liposomal daunorubicin versus observation for early Kaposi's sarcoma.: AIDS. 1996 May;10(5):515-9. Unique Identifier : AIDSLINE MED/96314099; Uthayakumar S; Bower M; Money-Kyrle J; Muyshondt C; Youle M; Hannon F; Phillips R; Gazzard BG; Boag F; Department of HIV and Genitourinary Medicine, Chelsea and; Westminster Hospital, London, UK.; OBJECTIVES: To evaluate single-agent liposomal daunorubicin chemotherapy in the management of early HIV-related Kaposi s sarcoma (KS). DESIGN: Randomized cross-over comparison of liposomal daunorubicin versus observation. SETTING: Study conducted at single site in tertiary referral HIV unit. PATIENTS: Twenty-nine HIV-
Nosocomial outbreak of tuberculosis in an outpatient HIV treatment room.: AIDS. 1996 May;10(5):521-5. Unique Identifier : AIDSLINE MED/96314100; Couldwell DL; Dore GJ; Harkness JL; Marriott DJ; Cooper DA; Edwards R; Li Y; Kaldor JM; HIV Medicine Unit, St Vincent's Hospital, University of New South; Wales, Sydney, Australia.; OBJECTIVE: To investigate a possible outbreak of tuberculosis in an outpatient HIV treatment facility in Sydney, Australia . DESIGN: Following the diagnosis of pulmonary tuberculosis in an attendee, a prospective screening program was instituted to investigate the potential outbr
Rapid increase in HIV-related tuberculosis, Chiang Rai, Thailand, 1990-1994.: AIDS. 1996 May;10(5):527-31. Unique Identifier : AIDSLINE MED/96314101; Yanai H; Uthaivoravit W; Panich V; Sawanpanyalert P; Chaimanee B; Akarasewi P; Limpakarnjanarat K; Nieburg P; Mastro TD; Research Institute of Tuberculosis, Tokyo, Japan.; OBJECTIVE: Chiang Rai, the northernmost province of Thailand , has experienced an explosive HIV epidemic since 1989. This study assessed the impact of HIV infection on tuberculosis (TB) in the area. METHODS: We analyzed the incidence of reported TB in the province from 1982 throug
Sexual mixing patterns in Uganda: small-time urban/rural traders.: AIDS. 1996 May;10(5):533-6. Unique Identifier : AIDSLINE MED/96314102; Pickering H; Okongo M; Bwanika K; Nnalusiba B; Whitworth J; Medical Research Council/Uganda Virus Research Institute,; Entebbe, Uganda.; OBJECTIVE: To document the extent to which rural and urban-based male traders have sexual contacts away from their place of residence. METHODS: Fifty-one traders (46 who travel by bicycle and five others) kept daily diaries of all their journeys and sexual contacts for a total of 584 person-weeks. Twenty-five were res
A controlled HIV/AIDS-related health education programme in Managua, Nicaragua.: AIDS. 1996 May;10(5):537-44. Unique Identifier : AIDSLINE MED/96314103; Pauw J; Ferrie J; Rivera Villegas R; Medrano Martinez J; Gorter A; Egger M; Asociacion de Trabajadores en Educacion, Salud e Integracion; Social (TESIS), Managua, Nicaragua.; OBJECTIVES: To evaluate the impact of a community-wide intervention to increase HIV/AIDS-related knowledge, change attitudes and increase safer-sex practices in Managua, Nicaragua . DESIGN AND SETTINGS: Household-based health education intervention trial comprising a knowledge, a
Human herpesvirus-8 in AIDS-related and unrelated lymphomas [letter]: AIDS. 1996 May;10(5):545-6. Unique Identifier : AIDSLINE MED/96314104; Corbellino M; Poirel L; Bestetti G; Aubin JT; Capra M; Berti E; Galli M; Parravicini C
Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation [letter]: AIDS. 1996 May;10(5):546-8. Unique Identifier : AIDSLINE MED/96314105; Veal GJ; Hoggard PG; Barry MG; Khoo S; Back DJ
Identification of HIV-1 viral RNA in intestinal tissue from patients with early and late HIV infection [letter]: AIDS. 1996 May;10(5):548-9. Unique Identifier : AIDSLINE MED/96314106; McGowan I; Tenant-Flowers M; Jewell DP
T-cell receptor V beta-specific expansions in children from HIV-infected mothers [letter]: AIDS. 1996 May;10(5):549-51. Unique Identifier : AIDSLINE MED/96314107; Silvestri G; Soudeyns H; Samson J; Denis F; Lapointe N; Sekaly RP
Hospital-based surveillance and emerging patterns of HIV transmission. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine (GECSA) [letter]: AIDS. 1996 May;10(5):551-2. Unique Identifier : AIDSLINE MED/96314108; De Chabalier F; Decoin M; Bonareck M; Ortega V; Marimoutou C; Dabis F
Where's the virus? Monitoring current HIV transmission patterns [letter]: AIDS. 1996 May;10(5):552-3. Unique Identifier : AIDSLINE MED/96314109; Sorvillo F; Kerndt PR
Origin of hyperamylasaemia in HIV-infected patients [letter]: AIDS. 1996 May;10(5):553-5. Unique Identifier : AIDSLINE MED/96314110; Boix V; Portilla J; Merino E; Perez-Mateo M
HIV infection among antenatal women in Zambia, 1990-1993 [letter]: AIDS. 1996 May;10(5):555-6. Unique Identifier : AIDSLINE MED/96314111; Fylkesnes K; Musonda RM; Luo NP; Msiska R
Factors related to inconsistent condom use with commercial sex workers in northern Thailand [letter]: AIDS. 1996 May;10(5):556-8. Unique Identifier : AIDSLINE MED/96314112; Kuntolbutra S; Celentano DD; Suprasert S; Eiumtrakol S; Wright NH; Nelson KE
The efficacy of nonoxynol-9 from an in vitro point of view [letter]: AIDS. 1996 May;10(5):558-9. Unique Identifier : AIDSLINE MED/96314113; Bourinbaiar AS; Fruhstorfer EC
Using bioinformatics in drug discovery.: Trends Biotechnol. 1996 Feb;14(2):37-9. Unique Identifier : AIDSLINE MED/96342200; Bains W; PA Consulting Group, Herts, UK. william.bains@pa-consulting.com
High quantifiable levels of p24 antigenemia are detectable in HIV type 1-infected patients [letter]: AIDS Res Hum Retroviruses. 1996 May 1;12(7):565-6. Unique Identifier : AIDSLINE MED/96291766; Varnier OE; Giacomini M; Lillo FB
ADA, a potential anti-HIV drug [letter]: AIDS Res Hum Retroviruses. 1996 May 1;12(7):567-8. Unique Identifier : AIDSLINE MED/96291767; Vandevelde M; Witvrouw M; Schmit JC; Sprecher S; De Clercq E; Tassignon JP
Doxorubicin inhibits Tat-dependent transactivation of HIV type 1 LTR.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):569-76. Unique Identifier : AIDSLINE MED/96291768; Jeyaseelan R; Kurabayashi M; Kedes L; Department of Biochemistry and Molecular Biology, University of; Southern California School of Medicine, Los Angeles 90033, USA.; Tat, the human immunodeficiency virus (HIV)-encoded transcription factor, is vital for HIV replication and transcription. Any drug that inhibits Tat s activity is a valuable candidate for chemotherapeutic applications. We show here that doxorubicin (Dox), a well-known anticancer drug and its derivative, daunomycin, in
Gamma delta-T cell-receptor-positive lymphocytes inhibit human hematopoietic progenitor cell growth in HIV type 1-infected patients.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):577-84. Unique Identifier : AIDSLINE MED/96291769; Geissler RG; Rossol R; Mentzel U; Ottmann OG; Klein AS; Gute P; Helm EB; Hoelzer D; Ganser A; Department of Hematology, Medizinische Hochschule Hannover,; Germany.; In severe HIV infection, the majority of patients exhibit signs of hematopoietic deficiency including anemia, leukopenia, and thrombocytopenia. Besides other pathophysiological mechanisms, the disturbed helper/suppressor ratio of T-lymphocytes suggests that alterations within T cell subpopulations may have a suppressi
Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):585-92. Unique Identifier : AIDSLINE MED/96291770; Harrer T; Harrer E; Kalams SA; Elbeik T; Staprans SI; Feinberg MB; Cao Y; Ho DD; Yilma T; Caliendo AM; Johnson RP; Buchbinder SP; Walker BD; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital, Boston, USA.; Some individuals in well-defined cohorts have now been infected with HIV-1 for well over a decade and yet remain clinically asymptomatic with normal CD4 counts. To determine immunologic and virologic parameters in these individuals, we examined 10 persons from the San Francisco City Clinic with firmly documented infec
Prediction of HIV peptide epitopes by a novel algorithm.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):593-610. Unique Identifier : AIDSLINE SWISSPROT/P04608; Roberts CG; Meister GE; Jesdale BM; Lieberman J; Berzofsky JA; De Groot AS; TB/HIV Research Laboratory, Brown University School of Medicine,; Providence, Rhode Island 02912, USA.; Identification of promiscuous or multideterminant T cell epitopes is essential for HIV vaccine development, however, current methods for T cell epitope identification are both cost intensive and labor intensive. We have developed a computer-driven algorithm, named EpiMer, which searches protein amino acid sequences fo
A monoclonal antibody defines a novel HIV type 1 Tat domain involved in trans-cellular trans-activation.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):611-9. Unique Identifier : AIDSLINE MED/96291772; Valvatne H; Szilvay AM; Helland DE; Laboratory for Biotechnology, University of Bergen, Norway.; In the present study, a CAT assay, a beta-galactosidase assay, and immunofluorescence analysis have been used to study the cellular uptake of the HIV-1 Tat protein. An anti-Tat MAb binding to an epitope comprising both the basic domain and the RGD sequence inhibits trans-activation by exogenous Tat. Two different full
Interferon gamma stimulates cell-mediated transmission of HIV type 1 from abortively infected endothelial cells.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):621-7. Unique Identifier : AIDSLINE MED/96291773; Dianzani F; Scheglovitova O; Gentile M; Scanio V; Barresi C; Ficociello B; Bianchi F; Fiumara D; Capobianchi MR; Institute of Virology, University La Sapienza, Rome, Italy.; Human umbilical vein endothelial cells (HUVEC) can be abortively infected with HIV-1, but virus production is rescued by T cells. The influence of interferon gamma (IFN-gamma) in this experimental system has been investigated. HUVEC either untreated or treated with IFN-gamma were infected with HIV-1 and cocultivated w
HIV type 1 Thai subtype E is predominant in South Vietnam.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):629-33. Unique Identifier : AIDSLINE GENBANK/U29209; Menu E; Truong TX; Lafon ME; Nguyen TH; Muller-Trutwin MC; Nguyen TT; Deslandres A; Chaouat G; Duong QT; Ha BK; Fleury HJ; Barre-Sinoussi F; Institut Pasteur, Unite de Biologie des Retrovirus, Paris,; France.
Endemicity and phylogeny of the human T cell lymphotropic virus type II subtype A from the Kayapo Indians of Brazil: evidence for limited regional dissemination.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):635-40. Unique Identifier : AIDSLINE GENBANK/L42507; Switzer WM; Black FL; Pieniazek D; Biggar RJ; Lal RB; Heneine W; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Long terminal repeat (LTR)-based restriction fragment length polymorphism (RFLP) analysis of human T cell lymphotropic virus type II (HTLV-II) from 17 seropositive Kayapo Indians from Brazil showed that all 17 samples contained a unique HTLV-IIa subtype (A-II). Additional RFLP scre
HIV type 1 subtypes B and C from new regions of India and Indian and Ethiopian expatriates in Kuwait.: AIDS Res Hum Retroviruses. 1996 May 1;12(7):641-3. Unique Identifier : AIDSLINE MED/96291776; Voevodin A; Crandall KA; Seth P; al Mufti S; Department of Microbiology, Faculty of Medicine, Kuwait; University, Kuwait.
Peripheral blood T cell subsets as prognostic indicators of chemotherapy outcome in AIDS patients with large cell lymphoma.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):645-9. Unique Identifier : AIDSLINE MED/96303582; Patarca R; Freidlander A; Harrington WJ; Cabral L; Byrnes JJ; Fletcher MA; Department of Medicine, University of Miami, School of Medicine,; E.M. Papper Laboratory of Clinical Immunology, Florida 33101,; USA.
Restricted tissue distribution of extralesional Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS patients with Kaposi's sarcoma.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):651-7. Unique Identifier : AIDSLINE MED/96303583; Corbellino M; Poirel L; Bestetti G; Pizzuto M; Aubin JT; Capra M; Bifulco C; Berti E; Agut H; Rizzardini G; Galli M; Parravicini C; Clinic of Infectious Diseases, University of Milano, L. Sacco; Hospital, Italy.; Specific herpesvirus-like DNA sequences have been found in Kaposi s sarcoma (KS) lesions of AIDS patients, suggesting that a novel gamma herpesvirus, homologous to Epstein-Barr virus and herpesvirus saimiri, could be implicated in the pathogenesis of KS. To better understand the role of this putative etiological agent
Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):659-68. Unique Identifier : AIDSLINE MED/96303584; Perales MA; Skolnik PR; Lieberman J; Center for Blood Research, Harvard Medical School, Boston,; Massachusetts 02155, USA.; CD8-depleted PBMCs from 20 HIV-1-seropositive donors were incubated in the presence of no cytokines, rIL-2, rIL-12, or both. HIV-1 replication, measured by culture supernatant p24 Ag, was increased to a comparable extent by either rIL-2 or rIL-12 in five of seven asymptomatic subjects and was not induced by either cyt
Virus load as a marker of disease progression in HIV-infected children.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):669-75. Unique Identifier : AIDSLINE MED/96303585; Tetali S; Abrams E; Bakshi S; Paul M; Oyaizu N; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York 11030, USA.; The relationship of virus load to clinical disease progression in HIV-infected children remains to be elucidated. In this study, HIV-1 proviral DNA load was determined in peripheral blood mononuclear cells (PBMCs) by the quantitative competitive DNA polymerase chain reaction assay (QC-PCR) in 47 HIV-infected children
Synergistic antiviral action of ribonucleotide reductase inhibitors and 3'-azido-3'-deoxythymidine on HIV type 1 infection in vitro.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):677-82. Unique Identifier : AIDSLINE MED/96303586; Giacca M; Borella S; Calderazzo F; Bianchi LC; D'Agaro P; Rampazzo C; Bianchi V; Reichard P; International Centre for Genetic Engineering and Biotechnology,; Padriciano, Trieste, Italy.; Ribonucleotide reductase inhibitors reduce the cellular supply of DNA precursors(dNTP) by interfering with their de novo synthesis. A secondary effect is the stimulation of the uptake and phosphorylation of extracellular deoxynucleosides, including their analogs, e.g., 3 -azidothymidine (
Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):683-93. Unique Identifier : AIDSLINE MED/96303587; Keefer MC; Graham BS; McElrath MJ; Matthews TJ; Stablein DM; Corey L; Wright PF; Lawrence D; Fast PE; Weinhold K; Hsieh RH; Chernoff D; Dekker C; Dolin R; Department of Medicine, University of Rochester School of; Medicine and Dentistry, New York 14642, USA.; We investigated the safety and immunogenicity of a candidate HIV-1 vaccine, Env 2-3 (Chiron Biocine Co.), in combination with an adjuvant emulsion, MF59, with or without an additional immune modulator, MTP-PE 78 healthy HIV-1-seronegative adults. Sixteen subjects participated in a dose escalation study of MTP-PE in MF
Membrane glycolipids and human immunodeficiency virus infection of primary macrophages.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):695-703. Unique Identifier : AIDSLINE MED/96303588; Seddiki N; Ben Younes-Chennoufi A; Benjouad A; Saffar L; Baumann N; Gluckman JC; Gattegno L; Laboratoire de Biologie Cellulaire, Universite Paris-Nord,; Bobigny, France.; The membrane glycolipids galactosylceramide (GalCer) and sulfatide (SGalCer) have been reported to act as receptors of human immunodeficiency virus (HIV) on CD4- cell lines. We show here that these glycolipids are present on CD4+ cells purified from human blood and on in vitro-differentiated monocyte-derived macrophag
Immunodominant glycoprotein 41 epitope identified by seroreactivity in HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):705-13. Unique Identifier : AIDSLINE MED/96303589; Calarota S; Jansson M; Levi M; Broliden K; Libonatti O; Wigzell H; Wahren B; Department of Microbiology, University of Buenos Aires School of; Medicine, Argentina.; A highly conserved gp41 epitope (amino acid sequence ELDKWA) has been described to elicit antibodies neutralizing a broad variety of HIV-1 strains. We analyzed the antibody reactivity of HIV-1-infected individuals from Argentina and Sweden to
Modulation of CD3-gamma gene expression after HIV type 1 infection of the WE17/10 T cell line is progressive and occurs in concert with decreased production of viral p24 antigen.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):715-25. Unique Identifier : AIDSLINE MED/96303590; Willard-Gallo KE; Delmelle-Wibaut C; Segura-Zapata I; Janssens M; Willems L; Kettmann R; International Institute of Cellular and Molecular Pathology; (ICP), Brussels, Belgium.; HIV-1 infection of WE17/10, an IL-2-dependent CD4+ human T cell line, abrogates T cell receptor (TCR)/CD3 expression due to a transcription level defect in the CD3-gamma chain gene. Kinetic examination of surface receptor density reveals that these complexes are progressively reduced early after HIV-1 infection as the
Deletion of the nef gene abrogates the ability of SIV smmPBj to induce acutely lethal disease in pigtail macaques.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):727-36. Unique Identifier : AIDSLINE MED/96303591; Novembre FJ; Lewis MG; Saucier MM; Yalley-Ogunro J; Brennan T; McKinnon K; Bellah S; McClure HM; Yerkes Regional Primate Research Center, Atlanta, Georgia 30322,; USA.; Simian immunodeficiency virus (SIV) infection in macaque species is typically associated with the development of a progressive immunodeficiency disease, similar to human AIDS, resulting in death of animals in months to years after infection. In contrast, a variant virus, termed SIVsmmPBj, induces an acute disease in m
HTLV infection in ELISA-negative blood donors.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):737-40. Unique Identifier : AIDSLINE MED/96303592; Zehender G; Girotto M; De Maddalena C; Francisco G; Moroni M; Galli M; Clinica delle Mallattie Infettive, Unversita di Milano, Italy.; Human T lymphotropic viruses (HTLVs) have a limited spread in the general populations of Western countries. Consequently, the transfusional risk for HTLV is consider to be low in Italy and the screening for anti-HTLV-I/II antibodies has not yet been introduced. In 1992, 1087 blood d
env gene sequences of primary HIV type 1 isolates of subtypes B, C, D, E, and F obtained from the World Health Organization Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1996 May 20;12(8):741-7. Unique Identifier : AIDSLINE GENBANK/U39261; Penny MA; Thomas SJ; Douglas NW; Ranjbar S; Holmes H; Daniels RS; Division of Virology, National Institute for Medical Research,; Mill Hill, London, UK.
Herpesvirus-like DNA sequences selectively cluster with body cavity-based lymphomas throughout the spectrum of AIDS-related lymphomatous effusions [letter]: Eur J Cancer. 1996 Mar;32A(3):555-6. Unique Identifier : AIDSLINE MED/96262933; Carbone A; Tirelli U; Gloghini A; Pastore C; Vaccher E; Gaidano G
Herpes simplex virus infection masquerading as condyloma acuminata in a patient with HIV disease.: Br J Dermatol. 1996 Apr;134(4):797-800. Unique Identifier : AIDSLINE MED/96297673; Tong P; Mutasim DF; Department of Dermatology, University of Cincinnati, Ohio; 45267-0523, USA.; Verrucous lesions in patients with human immunodeficiency virus (HIV) disease may be caused by viruses other than the human papillomavirus. We describe a 32-year-old HIV-positive black man who presented with a verrucous lesion of the intergluteal cleft that clinically resembled condyloma acuminata or verrucous carcino
Disseminated varioliform pustular eruption due to Mycobacterium avium intracellulare in an HIV-infected patient.: Br J Dermatol. 1996 Apr;134(4):801-3. Unique Identifier : AIDSLINE MED/96297674; Bachelez H; Ducloy G; Pinquier L; Rouveau M; Sibilla J; Dubertret L; Clinique des Maladies Cutanees, Hopital Saint-Louis, Paris,; France.; Severe disseminated infection due to Mycobacterium avium intracellulare, with unusual cutaneous features, is reported in a patient with acquired immunodeficiency syndrome (AIDS). The eruption appeared as disseminated pustular lesions which showed necrotic features and which led to varioliform scarring. Bacterial cultu
Acute exanthem and pancreatic panniculitis in a patient with primary HIV infection and haemophagocytic syndrome.: Br J Dermatol. 1996 Apr;134(4):804-7. Unique Identifier : AIDSLINE MED/96297675; Martinez-Escribano JA; Pedro F; Sabater V; Quecedo E; Navarro V; Aliaga A; Department of Dermatology, Hospital General, Valencia, Spain.; We report a patient with an acute infection with the human immunodeficiency virus (HIV), who initially presented due to a mononucleosis-like illness that included a rash on the upper trunk and limbs, and oral ulceration. The patient developed a haemophagocytic syndrome with severe systemic involvement. Three weeks aft
Staphylococcal scalded skin syndrome in an HIV-1 seropositive man.: Br J Dermatol. 1996 May;134(5):962-5. Unique Identifier : AIDSLINE MED/96297431; Farrell AM; Ross JS; Umasankar S; Bunker CB; Department of Dermatology, Chelsea and Westminster Hospital,; London, U.K.; The staphylococcal scalded skin syndrome (SSSS) is very rare in adults. Renal impairment and immunocompromise are predisposing causes. We report a 38-year-old HIV-1 seropositive intravenous drug abuser who developed SSSS due to staphylococcal pneumonia. An exfoliating toxin-releasing Staphylococcus aureus, phage type
Kaposi's sarcoma with primary bone lesions in an HIV-seronegative man.: Br J Dermatol. 1996 May;134(5):966-9. Unique Identifier : AIDSLINE MED/96297432; Lombardo M; Girolomoni G; Spina V; Zambruno G; Giannetti A; Department of Dermatology, University of Modena, Italy.; Classic Kaposi s sarcoma, with primary bone lesions, is described in an HIV-seronegative man. The bone involvement, painful lytic lesions in the right leg and both feet, was shown by magnetic resonance and histology not to be contiguous with the skin lesions. Chemotherapy with vinblastine and doxorubicin, significantl
Does HIV disease progression influence epidermal Langerhans cell density?: Br J Dermatol. 1996 Jun;134(6):1087-92. Unique Identifier : AIDSLINE MED/96287774; Nandwani R; Gazzard BG; Barton SE; Hawkins DA; Zemelman V; Staughton RC; Department of HIV/Genitourinary Medicine, Chelsea & Westminster; Hospital, London, U.K.; Langerhans cells (LC) are antigen-presenting CD4+ dendritic ce