Analysis of cell types and mediator production from tissues around loosening joint implants. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Analysis of cell types and mediator production from tissues around loosening joint implants.

Br J Rheumatol. 1995 Dec;34(12):1127-34. Unique Identifier : AIDSLINE MED/96188789
Perry MJ; Mortuza FY; Ponsford FM; Elson CJ; Atkins RM; Departments of Pathology, University of Bristol, UK.

Abstract: Quantitative immunophenotypic analysis of cell types present in peri-prosthetic tissue [pseudosynovial membrane (PSM)] from aseptically loose joint implants revealed considerable heterogeneity between tissues from different individuals. The monocyte/macrophage was the commonest leucocyte type; however, its proportion varied widely. T cells normally accounted for approximately 5% of cells, but in a few cases formed > 20% of cells. In all cases, there was a high ratio of CD4 to CD8 cells. PSM leucocytes were activated in most PSMs as judged by surface expression of CD23, CD25 and CD71. Analysis of the proportions of cell types in PSM, OA synovium and RA synovium revealed similarities between the different tissue types. The levels of IL-1, IL-6 and prostaglandin E produced by the PSM were correlated, but only IL-1 and IL-6 levels correlated with markers of the monocyte/macrophage lineage. This result suggests that prostaglandin E is produced in vivo by many PSM cell types.
Keywords: Adult Aged Aged, 80 and over Arthritis, Rheumatoid/METABOLISM/PATHOLOGY CD4-CD8 Ratio Flow Cytometry Human Immunophenotyping Interleukin-1/*METABOLISM Interleukin-6/*METABOLISM *Joint Prosthesis Middle Age Monocytes/PATHOLOGY Osteoarthritis/METABOLISM/PATHOLOGY Prostaglandins E/METABOLISM Prosthesis Failure Support, Non-U.S. Gov't Synovial Membrane/IMMUNOLOGY/METABOLISM/*PATHOLOGY T-Lymphocytes/PATHOLOGY JOURNAL ARTICLEKWDadultagedaged,80andoverarthritis,rheumatoid/metabolism/pathologycd4-cd8ratioflowcytometryhumanimmunophenotypinginterleukin-1/KWDmetabolisminterleukin-6/KWDmetabolismKWDjointprosthesismiddleagemonocytes/pathologyosteoarthritis/metabolism/pathologyprostaglandinse/metabolismprosthesisfailuresupport,non-uKWDsKWDgov'tsynovialmembrane/immunology/metabolism/KWDpathologyt-lymphocytes/pathologyjournalarticle
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M9681218

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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