Transgenic models of human immunodeficiency virus type-1. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Transgenic models of human immunodeficiency virus type-1.

Curr Top Microbiol Immunol. 1996;206:197-222. Unique Identifier : AIDSLINE MED/96195872
Klotman PE; Notkins AL; Mount Sinai Medical Center, Division of Nephrology, New York, NY; 10029, USA.

Abstract: Transgenic models have provided significant insights into HIV-1 pathogenesis, particularly with regards to Kaposi's sarcoma. HIV-associated nephropathy, the tissue-restricted expression of CNS strains of HIV-1, and the function of Nef in vivo. Both multigenic and single gene constructs have contributed to our understanding of HIV-1-induced diseases. While failing to provide models suitable for vaccine development, these transgenic models have provided great insight into HIV pathogenesis and may yet provide a means for the development and testing of molecular based therapies for AIDS.
Keywords: Animal Cachexia/ETIOLOGY Disease Models, Animal Female Genes, tat Growth Disorders/ETIOLOGY Human HIV Infections/*ETIOLOGY/PATHOLOGY HIV Long Terminal Repeat HIV-1/*GENETICS/*PATHOGENICITY Kidney Diseases/ETIOLOGY Mice Mice, Transgenic Pregnancy JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalcachexia/etiologydiseasemodels,animalfemalegenes,tatgrowthdisorders/etiologyhumanhivinfections/KWDetiology/pathologyhivlongterminalrepeathiv-1/KWDgenetics/KWDpathogenicitykidneydiseases/etiologymicemice,transgenicpregnancyjournalarticlereviewreview,tutorial
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