A common TCR beta-chain expressed by CD8+ intestinal mucosa T cells in ulcerative colitis.

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

A common TCR beta-chain expressed by CD8+ intestinal mucosa T cells in ulcerative colitis.

J Immunol. 1996 Apr 15;156(8):3024-35. Unique Identifier : AIDSLINE MED/96183261
Chott A; Probert CS; Gross GG; Blumberg RS; Balk SP; Hematology-Oncology Division, Beth Israel Hospital, Boston, MA; 02215, USA.

Abstract: The human intestine contains two populations of anatomically distinct T cells, intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), both of which preferentially use the TCR-alpha beta. Recent studies of TCR alpha- and beta-chain usage by intestinal intraepithelial lymphocytes, which are predominantly CD8+ T cells, have demonstrated that these cells are oligoclonal in normal intestine. This report examined the TCR beta-chains expressed by purified CD4+ and CD8+ T cells from normal colonic lamina propria and from the intestinal mucosa of patients with active ulcerative colitis (UC). The selective expansion of CD8+ T cell clones, and to a lesser extent CD4+ T cell clones, was observed among both normal LPLs and mucosal T cells in UC. These expanded LPL clones from normal donors were all distinct, but the mucosal T cells isolated from five of nine patients with UC contained CD8+ T cells expressing related V beta 3-J beta 1.6 TCRs. These observations provide evidence for an Ag-specific mucosal T cell response in UC. Further studies will be required to identify this Ag and address whether the T cell response to it plays a primary role in initiating the disease or is secondary to the inflammatory response.

Keywords: Amino Acid Sequence Base Sequence Basement Membrane/CHEMISTRY/IMMUNOLOGY Cloning, Molecular Colitis, Ulcerative/*IMMUNOLOGY/*METABOLISM/PATHOLOGY CD4-Positive T-Lymphocytes/CLASSIFICATION/METABOLISM CD8-Positive T-Lymphocytes/CLASSIFICATION/*METABOLISM Genes, Reiterated/IMMUNOLOGY Human Intestinal Mucosa/*IMMUNOLOGY/*METABOLISM/PATHOLOGY Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta/*BIOSYNTHESIS/CHEMISTRY/ GENETICS Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
960830
M9681182

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