Concurrent evolution of regions of the envelope and polymerase genes of human immunodeficiency virus type 1 during zidovudine (AZT) therapy. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

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Concurrent evolution of regions of the envelope and polymerase genes of human immunodeficiency virus type 1 during zidovudine (AZT) therapy.

J Gen Virol. 1996 May;77 ( Pt 5):1071-81. Unique Identifier : AIDSLINE GENBANK/U45421
Sheehy N; Desselberger U; Whitwell H; Ball JK; Regional Virus and Public Health Laboratory, Birmingham; Heartlands Hospital, UK.

Abstract: Nucleotide sequences of regions of the envelope (env) and polymerase (pol) genes of human immunodeficiency virus type 1 (HIV-1) proviral DNA were obtained from sequential blood and autopsy samples from an AIDS patient who had been treated with zidovudine for 9 months. Phylogenetic analyses showed that a reduction in genetic heterogeneity of the env regions of viruses present in the proviral blood population occurred during therapy, and this coincided with an increased pol gene heterogeneity. Differences were observed in different organs obtained post mortem for both the env and pol coding regions. The cardiac blood proviral population consisted mainly of variants which possessed sequences containing mutations at position 215 of the pol gene, associated with drug resistance. By contrast, the brain population consisted entirely of zidovudine sensitive genotypes, and this organ also harboured variants with genetically distinct env sequences. The lymph tissues obtained after death held more diverse proviral env and pol populations, containing both zidovudine sensitive and resistant genotypes.
Keywords: Amino Acid Sequence Antiviral Agents/*PHARMACOLOGY Base Sequence Drug Resistance *Genes, env *Genes, pol Human HIV-1/*DRUG EFFECTS/GENETICS Molecular Sequence Data Phylogeny RNA-Directed DNA Polymerase/GENETICS Support, Non-U.S. Gov't Zidovudine/*PHARMACOLOGY JOURNAL ARTICLEKWDaminoacidsequenceantiviralagents/KWDpharmacologybasesequencedrugresistanceKWDgenes,envKWDgenes,polhumanhiv-1/KWDdrugeffects/geneticsmolecularsequencedataphylogenyrna-directeddnapolymerase/geneticssupport,non-uKWDsKWDgov'tzidovudine/KWDpharmacologyjournalarticle
960830
M9681181

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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