Lack of evidence of HTLV-I/II infection in T CD8 malignant or reactive lymphoproliferative disorders in France: a serological and/or molecular study of 169 cases.

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Lack of evidence of HTLV-I/II infection in T CD8 malignant or reactive lymphoproliferative disorders in France: a serological and/or molecular study of 169 cases.

Leukemia. 1995 Dec;9(12):2087-92. Unique Identifier : AIDSLINE MED/96112601
Fouchard N; Flageul B; Bagot M; Avril MF; Hermine O; Sigaux F; Merle-Beral H; Troussard X; Delfraissy JF; de The G; et al; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris, France.

Abstract: Human T lymphotropic virus type II (HTLV-II), originally isolated in 1982 from a patient with a T hairy cell leukemia, has not yet been proven to be the causative agent of any specific hematological disease. In order to screen for such an event, and because HTLV-II has a preferential tropism for OKT8 (CD8) T cells (both in vivo and in vitro), we searched for the presence of HTLV-II in lymphoproliferative diseases (LP) of CD8+ T cells. We report a serological and/or molecular study of 169 patients with a T CD8 LP, including 76 patients with malignant or reactive T CD8 LP (34 lymphomas, 27 large granular leukemias, three prolymphocytic leukemias, one hairy cell leukemia, 11 reactive T CD8 LP) and 93 HIV-1+ patients with a T CD8 peripheral lymphocytosis ( > 1500/mm3) from a prospective HIV cohort involving 1264 individuals. In the first series, the 40 sera available were all HTLV-I/II negative, except a 67-year-old French Guyanan man, with a cutaneous large T CD8 cell lymphoma, HTLV-I+. Furthermore, the molecular analysis of the 69 available DNA samples by PCR failed to detect any proviral HTLV-I/II sequences, except for the HTLV-I+ patient. The serological study of the 93 HIV-1+ individuals with CD8 lymphocytosis, showed that three patients were HTLV-I+, but none was HTLV-II+. Thus, in contrast to HTLV-I, whose etiological role in adult T cell leukemia is now well established, there is neither epidemiological nor molecular evidence that prototypic HTLV-II may be etiologically associated specifically with any of the CD8+ T cell LP investigated in this report.

Keywords: Base Sequence CD8-Positive T-Lymphocytes/*PATHOLOGY/VIROLOGY Female France Human HTLV-I/*ISOLATION & PURIF HTLV-II/*ISOLATION & PURIF Lymphoproliferative Disorders/*VIROLOGY Male Middle Age Molecular Sequence Data Polymerase Chain Reaction Support, Non-U.S. Gov't JOURNAL ARTICLE
960830
M9681169

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