Diabetic peripheral neuropathy: a clinicopathologic and immunohistochemical analysis of sural nerve biopsies. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Diabetic peripheral neuropathy: a clinicopathologic and immunohistochemical analysis of sural nerve biopsies.

Muscle Nerve. 1996 Jun;19(6):722-7. Unique Identifier : AIDSLINE MED/96195499
Younger DS; Rosoklija G; Hays AP; Trojaborg W; Latov N; Department of Neurology, Columbia-Presbyterian Medical Center,; New York 10032, USA.

Abstract: We performed quantitative immunohistochemical studies of sural nerve biopsy specimens from 20 patients to determine whether endoneurial and epineurial lymphocytic infiltration occurs in diabetic nerves. The diabetic nerves contained a mean of 129 CD3+ cells per tissue section compared to 19 cells in patients with chronic neuropathy matched for the histologic severity of disease, and 0-5 cells in normal control nerves. The T-cell infiltrates in the diabetic nerves were predominantly of the CD8+ cell type. Activated endoneurial lymphocytes expressed immunoreactive cytokines and major histocompatibility class II antigens. Microvasculitis was found in 12 (60%) patients. Infiltrative T cells may contribute to the pathogenesis of diabetic neuropathy through a variety of effector mechanisms.
Keywords: Aged Aged, 80 and over Antigens, CD3/ANALYSIS Biopsy CD8-Positive T-Lymphocytes/IMMUNOLOGY/PATHOLOGY Demyelinating Diseases/PATHOLOGY Diabetes Mellitus, Insulin-Dependent/IMMUNOLOGY/PHYSIOPATHOLOGY Diabetes Mellitus, Non-Insulin-Dependent/IMMUNOLOGY/ PHYSIOPATHOLOGY Diabetic Neuropathies/IMMUNOLOGY/*PATHOLOGY Female Follow-Up Studies Human Immunoglobulins/ANALYSIS Immunohistochemistry/METHODS Lymphocytes/*IMMUNOLOGY/PATHOLOGY Macrophages/IMMUNOLOGY/PATHOLOGY Male Middle Age Nerve Fibers/PATHOLOGY/ULTRASTRUCTURE Support, Non-U.S. Gov't Sural Nerve/IMMUNOLOGY/*PATHOLOGY JOURNAL ARTICLE
960830
M9681156

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .