1996

Water-soluble block polycations as carriers for oligonucleotide delivery.: Bioconjug Chem. 1995 Nov-Dec;6(6):639-43. Unique Identifier : AIDSLINE MED/96167451; Kabanov AV; Vinogradov SV; Suzdaltseva YG; Alakhov VYu; Moscow Institute of Biotechnology, Inc., Faculty of Chemistry,; Moscow State University, Vorobievy Gory, Russia.; Water-soluble, block copolymeric carriers consisting of polyoxyethylene (PEO) and polyspermine (PS) chains have been developed for the delivery of antisense oligonucleotides (oligo) into the target cells. These copolymers spontaneously form complexes with oligos in aqueous solutions. The PS block electrostatically bin
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.: Blood. 1996 Feb 15;87(4):1232-7. Unique Identifier : AIDSLINE MED/96190035; Graubert TA; Russell JH; Ley TJ; Department of Internal Medicine and Genetics, Washington; University Medical School, St Louis, MO 63110, USA.; A complete molecular description of the syndromes of graft-versus-host disease (GVHD) and graft rejection could have a significant impact on clinical bone marrow transplantation. Recent in vitro experiments (Heusel et al, Cell 76:977, 1994 and Shresta et al, Proc Natl Acad Sci USA 92:5679, 1995) have shown that the pu
Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia.: Blood. 1996 Feb 15;87(4):1249-54. Unique Identifier : AIDSLINE MED/96190038; Robinson N; Sanders JE; Benyunes MC; Beach K; Lindgren C; Thompson JA; Appelbaum FR; Fefer A; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Allogeneic bone marrow transplantation (BMT) for advanced acute leukemia is associated with a high risk of relapse. It is postulated that interleukin-2 ( IL-2 ) administered after BMT might induce or amplify a graft-versus-leukemia effect and thereby reduce the relapse r
Development of human megakaryocytes: I. Hematopoietic progenitors (CD34+ bone marrow cells) are enriched with megakaryocytes expressing CD4.: Blood. 1996 Feb 15;87(4):1353-60. Unique Identifier : AIDSLINE MED/96190050; Dolzhanskiy A; Basch RS; Karpatkin S; Department of Pathology, New York University Medical Center, New; York 10016, USA.; CD34 is expressed by essentially all human hematopoietic progenitors including cells of the megakaryocyte (MK) lineage. We have previously reported CD4 expression by some human MK (Blood 81:2,664, 1993). To study the role of maturation on CD4 expression by MK, we examined CD34+ bone marrow cells for their expression o
Common Epstein-Barr virus (EBV) type-1 variant strains in both malignant and benign EBV-associated disorders.: Blood. 1996 Feb 15;87(4):1579-85. Unique Identifier : AIDSLINE MED/96190076; Schuster V; Ott G; Seidenspinner S; Kreth HW; Children's Hospital, University of Wurzburg, Germany.; In the present study, Epstein-Barr virus (EBV) isolates from 18 malignant tumors (angioimmunoblastic lymphadenopathy [AILD], n = 4; Hodgkin s disease [HD], n = 3; pleomorphic T-cell non-Hodgkin s lymphoma [T-NHL], n = 1; B-cell non-Hodgkin s lymphoma [B-NHL], n = 8; gastric carcino
AIDS now more chronic than fatal [news]: BMJ. 1996 Mar 30;312(7034):796-7. Unique Identifier : AIDSLINE MED/96211126; Roberts J
AIDS associated with blood transfusion and haemophilia in Europe [letter; comment]: BMJ. 1996 Mar 30;312(7034):847-8. Unique Identifier : AIDSLINE MED/96180816; Hamers F
Analysis of cell types and mediator production from tissues around loosening joint implants.: Br J Rheumatol. 1995 Dec;34(12):1127-34. Unique Identifier : AIDSLINE MED/96188789; Perry MJ; Mortuza FY; Ponsford FM; Elson CJ; Atkins RM; Departments of Pathology, University of Bristol, UK.; Quantitative immunophenotypic analysis of cell types present in peri-prosthetic tissue [pseudosynovial membrane (PSM)] from aseptically loose joint implants revealed considerable heterogeneity between tissues from different individuals. The monocyte/macrophage was the commonest leucocyte type; however, its proportion
Role of surfactant protein A in the pathogenesis of tuberculosis in subjects with human immunodeficiency virus infection.: Proc Assoc Am Physicians. 1995 Oct;107(3):340-5. Unique Identifier : AIDSLINE MED/96187439; Martin WJ 2nd; Downing JF; Williams MD; Pasula R; Twigg HL 3rd; Wright JR; Department of Internal Medicine, Indiana University School of; Medicine, Indianapolis, USA.; Human immunodeficiency virus (HIV)-infected subjects are at increased risk for tuberculosis even before there is a significant loss of CD4 lymphocytes. A factor was found to be present in the bronchoalveolar lavage (BAL) of HIV-infected subjects that promoted the attachment of M. tuberculosis (MTB) organisms to alveol
The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.: RNA. 1996 Mar;2(3):264-73. Unique Identifier : AIDSLINE MED/96196014; Simons FH; Rutjes SA; van Venrooij WJ; Pruijn GJ; Department of Biochemistry, University of Nijmegen, The; Netherlands.; Ro RNPs are evolutionarily conserved ribonucleoprotein particles that consist of a small RNA, known as Y RNA, associated with several proteins, such as La, Ro60, and Ro52. The Y RNAs (Y1-Y5), which are transcribed by RNA polymerase III, have been shown to reside almost exclusively in the cytoplasm as Ro RNPs. To obtai
A familial T-cell lymphoma with gamma delta phenotype and an original location. Possible role of chronic Epstein-Barr virus infection.: Cancer. 1996 Apr 15;77(8):1571-7. Unique Identifier : AIDSLINE MED/96197464; Donadieu J; Canioni D; Cuenod B; Fraitag S; Bodemer C; Stephan JL; Sigaux F; Le Deist F; Schraub S; Ranfraing E; Griscelli C; Brousse N; Unite d'Immuno-Hematologie Pediatrique, Hopital Necker Enfants; Malades, Paris, France.; BACKGROUND. We describe a familial lymphoproliferative syndrome associated with Epstein-Barr Virus (EBV) infection and the gamma delta phenotype. METHODS. We reviewed clinical, pathologic, immunologic, and virologic findings in a nonconsanguineous French family, collected over a 13-year period. Specimens from the fath
Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II).: Clin Exp Immunol. 1996 Mar;103(3):408-13. Unique Identifier : AIDSLINE MED/96188952; Jawahar S; Moody C; Chan M; Finberg R; Geha R; Chatila T; Division of Immunology, The Children's Hospital, Boston, MA, USA.; Susceptibility to herpes virus infections has been described in experimental animals depleted of NK cells and in patients with defective NK cell function. We have identified a child with recurrent infections, especially with herpes simplex virus, who had a decreased number of CD56(+)CD3(-) NK cells in circulation. Her
Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues.: Clin Exp Immunol. 1996 Mar;103(3):422-8. Unique Identifier : AIDSLINE MED/96188954; Fujihashi K; Yamamoto M; Hiroi T; Bamberg TV; McGhee JR; Kiyono H; Department of Oral Biology, The University of Alabama at; Birmingham, USA.; Elevated numbers of plasma cells are associated with localized and chronically inflamed gingiva of patients with adult periodontitis. However, only limited information is currently available as to how cytokines produced by CD4(+) T cells are involved in these increased B cell responses in affected gingival tissues. Wh
Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes.: Clin Exp Immunol. 1996 Mar;103(3):482-90. Unique Identifier : AIDSLINE MED/96188963; Lanza L; Scudeletti M; Puppo F; Bosco O; Peirano L; Filaci G; Fecarotta E; Vidali G; Indiveri F; Department of Internal Medicine (DI.M.I.), University of Genoa,; Italy.; Glucocorticoid hormones (GCH) regulate, through the apoptotic process, the negative selection of immature T cells in the thymus. Because apoptosis seems to occur also in the maintenance of peripheral tolerance, we have investigated whether GCH may induce apoptosis in human mature lymphocytes. Peripheral blood lymphocy
Production of IL-6 by T cells from the femoral head of patients with rapidly destructive coxopathy (RDC).: Clin Exp Immunol. 1996 Mar;103(3):506-13. Unique Identifier : AIDSLINE MED/96188966; Tamai M; Sagawa K; Kawabata R; Inoue A; Itoh K; Department of Immunology, Kurume University School of Medicine,; Fukuoka, Japan.; RDC is a syndrome with unknown etiology that causes rapid destruction of a hip joint. We have investigated the production of osteoclast-activating cytokines (IL-6, IL-1alpha and tumour necrosis factor-alpha (TNF-alpha)), interferon-gamma (IFN-gamma) and IL-8 by T cells in the affected joint. The level of IL-6 produced
Cytotoxic T cell effector and memory function in viral immunity.: Curr Top Microbiol Immunol. 1996;206:1-14. Unique Identifier : AIDSLINE MED/96195862; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.
Transgenic models of HTLV-I mediated disease and latency.: Curr Top Microbiol Immunol. 1996;206:175-96. Unique Identifier : AIDSLINE MED/96195871; Nerenberg M; Xu X; Brown DA; Department of Neuropharmacology and Molecular and Experimental; Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
Transgenic models of human immunodeficiency virus type-1.: Curr Top Microbiol Immunol. 1996;206:197-222. Unique Identifier : AIDSLINE MED/96195872; Klotman PE; Notkins AL; Mount Sinai Medical Center, Division of Nephrology, New York, NY; 10029, USA.; Transgenic models have provided significant insights into HIV-1 pathogenesis, particularly with regards to Kaposi s sarcoma. HIV-associated nephropathy, the tissue-restricted expression of CNS strains of HIV-1, and the function of Nef in vivo. Both multigenic and single gene constructs have contributed to our understa
Transgenic models in the study of AIDS dementia complex.: Curr Top Microbiol Immunol. 1996;206:223-41. Unique Identifier : AIDSLINE MED/96195873; Toggas SM; Mucke L; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, CA 92037, USA.
Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: role of the viral transactivator Tax.: Int J Cancer. 1996 Mar 28;66(1):124-9. Unique Identifier : AIDSLINE MED/96183757; Baba M; Imai T; Yoshida T; Yoshie O; Shionogi Institute for Medical Science, Osaka, Japan.; We examined the genetic expression of 2 CXC chemokines (IL-8, IP-10), 5 CC chemokines (MCP-1, MIP-lalpha, MIP-1beta, RANTES, 1309) and 1 C chemokine (SCM-1/lymphotactin/ATAC) in various human T-cell lines. By Northern blot analysis, HTLV-1-positive T-cell lines were found to express a number of chemokine genes at vari
Detection of human T-lymphotropic virus type-I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ISH) and reverse transcription (RT-PCR/ISH).: Int J Cancer. 1996 Mar 28;66(1):18-23. Unique Identifier : AIDSLINE MED/96183740; Ohshima K; Suzumiya J; Izumo S; Mukai Y; Tashiro K; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; To examine the relationship between human T-lymphotrophic virus type I (HTLV-I) proviral DNA and its expression in the lymph nodes, HTLV-I DNA and tax/rex mRDA were directly amplified by polymerase chain reaction in situ hybridization (PCR/ISH), and reverse transcription (RT)-PCR/ISH [RT-PCR/ISH]. We studied 24 lymph
Cancer in Rwanda.: Int J Cancer. 1996 Mar 28;66(1):75-81. Unique Identifier : AIDSLINE MED/96183750; Newton R; Ngilimana PJ; Grulich A; Beral V; Sindikubwabo B; Nganyira A; Parkin DM; ICRF Cancer Epidemiology Unit, Oxford, UK.; Data are presented on the frequency of malignant tumours registered at the population-based cancer registry in the southern prefecture of Butare, Rwanda , from May 1991 until 2 months before the outbreak of civil war in April 1994. Beginning in 1992, subjects were also interviewed a
ICN calls for HIV/AIDS protection for nurses/midwives [news]: Int Nurs Rev. 1995 Nov-Dec;42(6):168-9. Unique Identifier : AIDSLINE MED/96192651
ICN statement on impact of HIV/AIDS on nursing/midwifery personnel [news]: Int Nurs Rev. 1995 Nov-Dec;42(6):168-9. Unique Identifier : AIDSLINE MED/96192652
Update on AIDS pandemic [news]: Int Nurs Rev. 1995 Nov-Dec;42(6):169. Unique Identifier : AIDSLINE MED/96192653
Health professionals and HIV [news]: Hastings Cent Rep. 1995 Nov-Dec;25(6):48. Unique Identifier : AIDSLINE MED/96192625; Moskawitz E
Human T-lymphotropic virus type II in Japan.: Jpn J Cancer Res. 1996 Jan;87(1):1-4. Unique Identifier : AIDSLINE MED/96195784; Yoshizaki H; Kitamura K; Oki A; Yahara S; Yamanaka R; Fukushima Y; Komuro K; Yamazaki S; Honda M; Laboratory of Immunology, AIDS Research Center, National; Institute of Health, Tokyo.; Serum specimens were assayed for human T-lymphotropic virus type II(HTLV-II) infection in 1,500 individuals known to be seropositive for HTLV-I and 30,000 blood donors in Japan . All HTLV-I-positive individuals were negative for HTLV-II. However, one of the blood donors was clearly s
New bellenamine homologs inhibiting human immunodeficiency virus type I infectivity.: J Antibiot (Tokyo). 1996 Jan;49(1):113-8. Unique Identifier : AIDSLINE MED/96180363; Kondo S; Ikeda Y; Takeuchi T; Shinei R; Gomi S; Shibahara S; Haraguchi Y; Ikeda R; Hoshino H; Institute of Microbial Chemistry, Tokyo, Japan.
Novel spirodihydrobenzofuranlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys Sp. I. Fermentation, isolation and biological activity.: J Antibiot (Tokyo). 1996 Jan;49(1):13-9. Unique Identifier : AIDSLINE MED/96180343; Roggo BE; Petersen F; Sills M; Roesel JL; Moerker T; Peter HH; Core Drug Discovery Technologies, Pharmaceutical Division,; Ciba-Geigy Limited, Basel, Switzerland.; Six novel spirodihydrobenzofuranlactams I - VI (1 - 6) and a related spirodihydrobenzofuranalcohol, the previously described natural compound L-671,776 (7), were isolated from cultures of two different Stachybotrys species. These secondary metabolites showed antagonistic effects in the endothelin receptor binding assa
A young man with an illness mimicking HIV infection.: Hosp Pract (Off Ed). 1996 Apr 15;31(4):190-4. Unique Identifier : AIDSLINE MED/96185948; McDonald E; Marino C; Department of Medicine, St. John's Queens Hospital, Catholic; Medical Center of Brooklyn and Queens, Jamaica, N.Y., USA.
Hyperglycemia in an AIDS patient taking megestrol.: Hosp Pract (Off Ed). 1996 Apr 15;31(4):27-8. Unique Identifier : AIDSLINE MED/96185937; Pimentel G; Santos E; Arastu M; Cowan JA; St. Luke's Hospital, Bethlehem, Pa., USA.
Patterns and predictability in emerging infections.: Hosp Pract (Off Ed). 1996 Apr 15;31(4):85-91, 96-101, 104 passim. Unique Identifier : AIDSLINE MED/96185942; Morse SS; Rockefeller University, New York, N.Y., USA.; Many seemingly novel infections have a long history as zoonoses, and perhaps in sporadic human hosts; they gain access to new host populations through ecologic changes and human activity. identification of patterns in the emergence of such illnesses--ranging from influenza and Lyme disease to Ebola fever and AIDS--sug
Polymerase chain reaction method for determining ratios of human immunodeficiency virus proviral DNA to cellular genomic DNA in brain tissues of HIV-infected patients.: J Virol Methods. 1995 Nov;55(3):309-25. Unique Identifier : AIDSLINE MED/96187322; Fujimura RK; Bockstahler LE; Molecular Biology Branch, Food and Drug Administration,; Rockville, MD 20857, USA.; A PCR method was developed to compare HIV-1 DNA loads in brain tissue samples. The method determines the ratio of the amplified product of an HIV DNA sequence to that of a host cellular DNA sequence using standard DNAs as reference. The standards include DNA from a line of human cells that harbor one HIV-1 provirus pe
Poly A-linked non-isotopic microtiter plate reverse transcriptase assay for sensitive detection of clinical human immunodeficiency virus isolates.: J Virol Methods. 1995 Nov;55(3):347-56. Unique Identifier : AIDSLINE MED/96187325; Suzuki K; Saito T; Kondo M; Osanai M; Watanabe S; Kano T; Kano K; Imai M; Biomedical Research Center, Olympus Optical Co. Ltd., Tokyo,; Japan.; A colorimetric reverse transcriptase assay (cRT assay) was developed for quantitative detection of HIV-1. In this format, reverse transcriptase incorporates biotin-labeled dUTP onto oligo-dT primers hybridized to poly A templates. The templates are covalently bound to the surface of microtiter wells. The amount of inc
Detection of southern African human immunodeficiency virus type 1 subtypes by polymerase chain reaction: evaluation of different primer pairs and conditions.: J Virol Methods. 1995 Nov;55(3):391-400. Unique Identifier : AIDSLINE MED/96187329; Engelbrecht S; van Rensburg EJ; Department of Medical Virology, University of Stellenbosch,; Tygerberg, South Africa.; The purpose of the study was to develop a specific and sensitive PCR protocol using env, gag and LTR primer pairs to detect HIV-1 subtypes present in the Western Cape, South Africa . Twenty-two virus strains, belonging to HIV-1 subtypes B, C and D, were randomly selected for PCR ev
Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis.: J Clin Invest. 1996 Feb 1;97(3):789-98. Unique Identifier : AIDSLINE MED/96189959; Wyss-Coray T; Masliah E; Toggas SM; Rockenstein EM; Brooker MJ; Lee HS; Mucke L; Gladstone Molecular Neurobiology Program, University of; California, San Francisco 94141-9100, USA.; HIV-1 associated central nervous system (CNS) disease involves neuronal damage and prominent reactive astrocytosis, the latter characterized by strong upregulation of the glial fibrillary acidic protein (GFAP) in astrocytes. Similar alterations are found in transgenic mice expressing the HIV-1 envelope protein gp120 i
Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.: J Clin Invest. 1996 Feb 1;97(3):865-9. Unique Identifier : AIDSLINE MED/96189969; Kaveri S; Vassilev T; Hurez V; Lengagne R; Lefranc C; Cot S; Pouletty P; Glotz D; Kazatchkine MD; Institut National de la Sante et de la Recherche Medicale U430,; Hopital Broussais, Paris, France.; Intravenous immunoglobulin (IVIg) is increasingly used for the treatment of autoimmune diseases and the prevention of infections and of graft versus host reactions in recipients of allogeneic bone marrow transplants. The immunomodulatory effects of IVIg are largely dependent on their ability to interact with membrane
Worldly and workday worries: contemporary concerns of children and young adolescents.: J Abnorm Child Psychol. 1995 Dec;23(6):685-702. Unique Identifier : AIDSLINE MED/96192672; Henker B; Whalen CK; O'Neil R; Department of Psychology, University of California, Los Angeles; 90095-1563, USA.; Top-of-the-head worries were elicited young people, grade 4 to 8, both before and after they completed quantitative risk assessments of specific health and environmental problems. Results revealed that many students carry a substantial worry burden that includes not only personal matters such as grades and social rela
Dental management of the HIV-infected patient.: J Am Dent Assoc. 1995 Dec;Suppl:1-40. Unique Identifier : AIDSLINE MED/96193435
Vitamin A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway.: J Immunol. 1996 Apr 15;156(8):2674-9. Unique Identifier : AIDSLINE MED/96183217; Cantorna MT; Nashold FE; Chun TY; Hayes CE; Department of Biochemistry, University of Wisconsin-Madison, WI; 53706, USA.; Some infections deplete serum retinol, low retinol reduces immunity, and reduced immunity establishes susceptibility to further infection in a cyclical relationship that is poorly understood. We showed that when retinol was low, there was excessive Th1 cell IFN-gamma synthesis and inadequate Th2 cell IL-4 and IL-5 syn
Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile.: J Immunol. 1996 Apr 15;156(8):2680-5. Unique Identifier : AIDSLINE MED/96183218; Coyle AJ; Tsuyuki S; Bertrand C; Huang S; Aguet M; Alkan SS; Anderson GP; Department of Allergy and Asthma Research, CIBA-GEIGY Ltd.,; Basel, Switzerland.; To investigate the modulatory role of IFN-gamma on the induction and maintenance of Th2 mucosal immunity in vivo, experiments were performed in mice lacking the IFN-gamma R. Aerosol OVA challenge of immunized wild-type mice resulted in an infiltration of eosinophils into the lung, associated with the ex vivo productio
Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.: J Immunol. 1996 Apr 15;156(8):2710-5. Unique Identifier : AIDSLINE MED/96183222; Fujiura Y; Kawaguchi M; Kondo Y; Obana S; Yamamoto H; Nanno M; Ishikawa H; Department of Microbiology, Keio University School of Medicine,; Tokyo, Japan.; The development of CD8+ intestinal intraepithelial T lymphocytes (IEL) was analyzed in mice that are deficient in the expression of MHC class I molecules, owing to either a mutated beta 2-microglobulin (beta 2m) gene or a mutated transporter associated with Ag processing 1 (TAP1) gene, and in mice doubly homozygous fo
Regulation of CTL by ecto-nictinamide adenine dinucleotide (NAD) involves ADP-ribosylation of a p56lck-associated protein.: J Immunol. 1996 Apr 15;156(8):2819-27. Unique Identifier : AIDSLINE MED/96183236; Wang J; Nemoto E; Dennert G; Department of Molecular Immunology, University of Southern; California School of Medicine, Los Angeles 90033, USA.; Receptor-mediated activation of T lymphocytes involves protein phosphorylation by several protein tyrosine kinases, among those the src-related enzymes p56lck and p59fyn. Accumulating evidence supports the notion that these enzymes are regulated by tyrosine phosphorylation and dephosphorylation, but much is yet to be
A common TCR beta-chain expressed by CD8+ intestinal mucosa T cells in ulcerative colitis.: J Immunol. 1996 Apr 15;156(8):3024-35. Unique Identifier : AIDSLINE MED/96183261; Chott A; Probert CS; Gross GG; Blumberg RS; Balk SP; Hematology-Oncology Division, Beth Israel Hospital, Boston, MA; 02215, USA.; The human intestine contains two populations of anatomically distinct T cells, intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), both of which preferentially use the TCR-alpha beta. Recent studies of TCR alpha- and beta-chain usage by intestinal intraepithelial lymphocytes, which are predominantly CD8
Concurrent evolution of regions of the envelope and polymerase genes of human immunodeficiency virus type 1 during zidovudine (AZT) therapy.: J Gen Virol. 1996 May;77 ( Pt 5):1071-81. Unique Identifier : AIDSLINE GENBANK/U45421; Sheehy N; Desselberger U; Whitwell H; Ball JK; Regional Virus and Public Health Laboratory, Birmingham; Heartlands Hospital, UK.; Nucleotide sequences of regions of the envelope (env) and polymerase (pol) genes of human immunodeficiency virus type 1 (HIV-1) proviral DNA were obtained from sequential blood and autopsy samples from an AIDS patient who had been treated with zidovudine for 9 months. Phylogenetic analyses showed that a reduction in g
An additional mechanism of growth restriction in T cell line H9 of human immunodeficiency virus type 1 isolates from asymptomatic homosexual men.: J Gen Virol. 1996 May;77 ( Pt 5):1083-8. Unique Identifier : AIDSLINE MED/96201456; Balachandran R; Singh MK; Gupta P; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, PA 15261, USA.; The replicative properties of human immunodeficiency virus type 1 (HIV-1) isolates from asymptomatic carriers (asymptomatic isolates) and AIDS patients (AIDS isolates) were examined in the human T lymphocyte cell line H9. In agreement with earlier reports the replication of asymptomatic isolates was restricted whereas
The presence of a divergent T-lymphotropic virus in a wild-caught pygmy chimpanzee (Pan paniscus) supports an African origin for the human T-lymphotropic/simian T-lymphotropic group of viruses.: J Gen Virol. 1996 May;77 ( Pt 5):1089-99. Unique Identifier : AIDSLINE GENBANK/X83120; Vandamme AM; Liu HF; Van Brussel M; De Meurichy W; Desmyter J; Goubau P; Rega Institute for Medical Research, Leuven, Belgium.; We isolated a divergent simian T-lymphotropic virus (STLV) (strain PP1664) from a wild-caught African bonobo (pygmy chimpanzee, Pan paniscus). Molecular and phylogenetic characterization of this virus show that it reliably separates from the two well-established primate T-lymphotropic virus types, HTLV-I/STLV-I (PTLV-
Staphylococcus aureus colonisation and bacteraemia in persons infected with human immunodeficiency virus: a dynamic interaction with the host.: J Chemother. 1995 Jul;7 Suppl 3:19-28. Unique Identifier : AIDSLINE MED/96192761; Craven DE; Department of Medicine, Boston University School of Medicine,; Boston City Hospital, MA 02118, USA.; Bacterial infections are common in persons with symptomatic disease caused by human immunodeficiency virus (HIV). Colonisation and infection with Staphylococcus aureus is present in 30% to 50% of persons with HIV disease. Risk factors for bacteraemia due to S. aureus include nasal colonisation, advanced HIV disease wi
Sexual sensation seeking and Sexual Compulsivity Scales: reliability, validity, and predicting HIV risk behavior.: J Pers Assess. 1995 Dec;65(3):586-601. Unique Identifier : AIDSLINE MED/96191189; Kalichman SC; Rompa D; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, USA.; Two studies are presented that evaluate newly developed scales of sensation seeking and sexual compulsivity. Results showed that the scales were reliable and correlated with convergent and divergent measures in expected directions in samples of both gay men (N = 296) and inner city low-income men and women (N = 158).
Affinity maturation of a high-affinity human monoclonal antibody against the third hypervariable loop of human immunodeficiency virus: use of phage display to improve affinity and broaden strain reactivity.: J Mol Biol. 1996 Feb 16;256(1):77-88. Unique Identifier : AIDSLINE MED/96190953; Thompson J; Pope T; Tung JS; Chan C; Hollis G; Mark G; Johnson KS; Cambridge Antibody Technology Ltd, Melbourn Cambridgeshire, UK.; The present study set out to investigate whether phage display could be used to improve the properties of a high-affinity human monoclonal antibody directed against the third hypervariable loop (V3 loop) of human immunodeficiency virus (HIV). The aim was to increase affinity through slowing the dissociation rate (off-
Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.: J Mol Biol. 1996 Mar 29;257(2):246-64. Unique Identifier : AIDSLINE MED/96180013; Mikaelian I; Krieg M; Gait MJ; Karn J; MRC Laboratory of Molecular Biology, Cambridge, UK.; The human immunodeficiency virus type (HIV-1) Rev protein stimulates the export to the cytoplasm of unspliced HIV-1 mRNAs carrying the Rev response element (RRE). However, simple addition of the RRE to beta-globin pre-mRNA does not confer a Rev response on this heterologous transcript. In this paper, we demonstrate th
AIDS malignancy research gets a home at NCI [news]: J Natl Cancer Inst. 1996 Mar 20;88(6):320-1. Unique Identifier : AIDSLINE MED/96194356; McNeil C
AIDS malignancy consortium plans first clinical trials.[news]: J Natl Cancer Inst. 1996 Mar 20;88(6):321. Unique Identifier : AIDSLINE MED/96194357; McNeil C
Presence of Mason-Pfizer monkey virus in some stocks of the human HBL-100 mammary epithelial cell line.: J Natl Cancer Inst. 1996 Mar 20;88(6):372-4. Unique Identifier : AIDSLINE MED/96194364; Robert-Guroff M; Stern TL; Richardson ES; Giovanella BC; Michaels FH; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892-4255, USA.
In vitro infection of leukemic bone marrow with HTLV-I generates immortalized cell lines expressing T or myeloid cell phenotype.: Leukemia. 1995 Dec;9(12):2071-81. Unique Identifier : AIDSLINE MED/96112599; Giuliani A; Vernole P; D'Atri S; Del Poeta G; D'Onofrio C; Faraoni I; Greiner JW; Bonmassar E; Graziani G; Institute of Experimental Medicine, National Council of Research; CNR, Rome, Italy.; Leukemic bone marrow cells ( > 90% blasts) of a patient with acute myeloblastic leukemia (AML), non-treated or pretreated in vitro with a mutagenic triazene compound, were infected with HTLV-I by coculture with irradiated virus-donor cells. Immortalized, HTLV-I+, double-positive CD4/CD8 euploid T cell lines, expressin
Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes.: Leukemia. 1995 Dec;9(12):2082-6. Unique Identifier : AIDSLINE MED/96112600; Gartenhaus RB; Wang P; Division of Hematology/Oncology, Long Island Jewish Medical; Center, NY, USA.; Human T cell leukemia virus type-I (HTLV-I), the etiologic agent of adult T cell leukemia (ATL) transforms human T cells in vitro and in vivo. Tax, the major transactivator of HTLV-I is critical for the initial events involved in transformation, however, the later steps required for progression from an
Lack of evidence of HTLV-I/II infection in T CD8 malignant or reactive lymphoproliferative disorders in France: a serological and/or molecular study of 169 cases.: Leukemia. 1995 Dec;9(12):2087-92. Unique Identifier : AIDSLINE MED/96112601; Fouchard N; Flageul B; Bagot M; Avril MF; Hermine O; Sigaux F; Merle-Beral H; Troussard X; Delfraissy JF; de The G; et al; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris, France.; Human T lymphotropic virus type II (HTLV-II), originally isolated in 1982 from a patient with a T hairy cell leukemia, has not yet been proven to be the causative agent of any specific hematological disease. In order to screen for such an event, and because HTLV-II has a preferential tropism for OKT8 (CD8) T cells (bo
Trial results thwart HIV-vaccine hopes [news]: Lancet. 1996 Apr 27;347(9009):1173. Unique Identifier : AIDSLINE MED/96198391; McCarthy M
India's railways relent over AIDS passengers [news]: Lancet. 1996 Apr 27;347(9009):1178. Unique Identifier : AIDSLINE MED/96198403; Kumar S
Revelations rock Canada's tainted-blood inquiry [news]: Lancet. 1996 Apr 27;347(9009):1178. Unique Identifier : AIDSLINE MED/96198401; Kondro W
HIV-induced neurological disease.: Med J Aust. 1996 Apr 1;164(7):414-7. Unique Identifier : AIDSLINE MED/96188814; Wright EJ; Brew BJ; Currie JN; McArthur JC; HIV/AIDS Unit, Fairfield Hospital, Melbourne VIC, Australia.
HIV and opportunistic neurological infections.: Med J Aust. 1996 Apr 1;164(7):418-21. Unique Identifier : AIDSLINE MED/96188815; Jones PD; Beaman MH; Brew BJ; Department of Infectious Diseases, Prince Henry Hospital, Sydney,; NSW, Australia.
HIV and psychiatric disorders.: Med J Aust. 1996 Apr 1;164(7):422-4. Unique Identifier : AIDSLINE MED/96188816; Buhrich N; Judd FK; Department of Psychiatric Services, St Vincent's Hospital,; Sydney, NSW, Australia.
HIV and respiratory disease.: Med J Aust. 1996 Apr 1;164(7):425-8. Unique Identifier : AIDSLINE MED/96188817; Smith AI; Pigott PC; Department of Respiratory Medicine, Royal North Shore Hospital,; Sydney, NSW, Australia.
Alterations in lymphocytes as a result of burns [letter]: Med J Aust. 1996 Apr 1;164(7):445. Unique Identifier : AIDSLINE MED/96188824; O'Kane GM; Gottlieb T; Bradbury R; Kennedy P
Suspected ethambutol-induced mania [letter]: Med J Aust. 1996 Apr 1;164(7):445-6. Unique Identifier : AIDSLINE MED/96188825; Pickles RW; Spelman DW
Cytomegalovirus retinitis in patients with AIDS: current status [letter]: Med J Aust. 1996 Apr 1;164(7):446. Unique Identifier : AIDSLINE MED/96188826; Nichols TT
AIDS associated with injecting-drug use--United States, 1995.: MMWR Morb Mortal Wkly Rep. 1996 May 17;45(19):392-8. Unique Identifier : AIDSLINE MED/96205847; Injecting-drug use is the second most frequently reported risk behavior for infection with human immunodeficiency virus (HIV). As of December 31, 1995, of 513,486 cases of acquired immunodeficiency syndrome (AIDS) reported to CDC, 184,359 (36%) were directly or indirectly associated with injecting-drug use. Injecting-
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.: Mol Pharmacol. 1996 Apr;49(4):621-8. Unique Identifier : AIDSLINE MED/96183084; Mazumder A; Neamati N; Sommadossi JP; Gosselin G; Schinazi RF; Imbach JL; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.; We extended our previous study with 3 -azido-3 -deoxythymidine nucleotides [Proc. Natl. Acad. Sci. USA 91:5771-5775 (1994)] and examined the effects on human immunodeficiency virus type 1 (HIV-1) integrase of the nucleotides of three nucleoside analogues currently under evaluation in clinical trials: beta-D-2 ,3 -dide
Diabetic peripheral neuropathy: a clinicopathologic and immunohistochemical analysis of sural nerve biopsies.: Muscle Nerve. 1996 Jun;19(6):722-7. Unique Identifier : AIDSLINE MED/96195499; Younger DS; Rosoklija G; Hays AP; Trojaborg W; Latov N; Department of Neurology, Columbia-Presbyterian Medical Center,; New York 10032, USA.; We performed quantitative immunohistochemical studies of sural nerve biopsy specimens from 20 patients to determine whether endoneurial and epineurial lymphocytic infiltration occurs in diabetic nerves. The diabetic nerves contained a mean of 129 CD3+ cells per tissue section compared to 19 cells in patients with chro
Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection.: N Engl J Med. 1996 May 16;334(20):1292-7. Unique Identifier : AIDSLINE MED/96200569; Miller G; Rigsby MO; Heston L; Grogan E; Sun R; Metroka C; Levy JA; Gao SJ; Chang Y; Moore P; Department of Pediatrics, Yale University School of Medicine, New; Haven, Conn 06520, USA.; BACKGROUND. The recent identification in patients with Kaposi s sarcoma of DNA sequences with homology to gammaherpesviruses has led to the hypothesis that a newly identified virus, Kaposi s sarcoma-associated herpeslike virus (KSHV), has a role in the pathogenesis of Kaposi s sarcoma. We developed serologic markers f
Kaposi's sarcoma and herpesvirus-like DNA sequences in sensory ganglia [letter]: N Engl J Med. 1996 May 16;334(20):1341-2. Unique Identifier : AIDSLINE MED/96200590; Corbellino M; Parravicini C; Aubin JT; Berti E
AIDS office opposes outside planning [news]: Nature. 1996 May 2;381(6577):5. Unique Identifier : AIDSLINE MED/96196490; Wadman M
Recognizing and managing HIV infection in women [news]: Nurse Pract. 1995 Dec;20(12):52-3. Unique Identifier : AIDSLINE MED/96193058; Klaus BD
Cognitive impairment with HIV [letter]: Nurse Pract. 1995 Dec;20(12):6. Unique Identifier : AIDSLINE MED/96193049; Buck B
Universal precautions training of preclinical students: impact on knowledge, attitudes, and compliance.: Prev Med. 1995 Nov;24(6):580-5. Unique Identifier : AIDSLINE MED/96197576; Diekema DJ; Schuldt SS; Albanese MA; Doebbeling BN; Department of Internal Medicine, University of Iowa College of; Medicine, Iowa City 52242, USA.; BACKGROUND: Little information exists regarding the impact of universal precautions training programs on preclinical students knowledge, attitudes, and behavior. METHODS: We developed, implemented, and assessed an educational program in universal precautions for 2nd-year medical and preclinical physician assistant st
Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2889-94. Unique Identifier : AIDSLINE MED/96181502; Woffendin C; Ranga U; Yang Z; Xu L; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; The resistance of acquired immunodeficiency syndrome (AIDS) to traditional drug therapy has prompted a search for alternative treatments for this disease. One potential approach is to provide genetic resistance to viral replication to prolong latency. This strategy requires the definition of effective antiviral genes
Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2897-902. Unique Identifier : AIDSLINE MED/96181504; Bamford RN; Battiata AP; Burton JD; Sharma H; Waldmann TA; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892-1374, USA.; We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires interleukin (IL) 2 receptor beta-subunit expression for its action. Using anti-cytokine antibodies, we demonstrated that IL-T is
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2936-40. Unique Identifier : AIDSLINE MED/96181511; Fridell RA; Fischer U; Luhrmann R; Meyer BE; Meinkoth JL; Malim MH; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710, USA.; The human immunodeficiency virus type 1 (HIV-1) Rev protein is required for nuclear export of late HIV-1 mRNAs. This function is dependent on the mutationally defined Rev activation domain, which also forms a potent nuclear export signal. Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interac
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3031-6. Unique Identifier : AIDSLINE MED/96181528; Liblau RS; Tisch R; Shokat K; Yang X; Dumont N; Goodnow CC; McDevitt HO; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA 94305, USA.; The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138. After intravenous injection of 750 (but not 75) microgram
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104. Unique Identifier : AIDSLINE MED/96181540; Hill CP; Worthylake D; Bancroft DP; Christensen AM; Sundquist WI; Department of Biochemistry, University of Utah, Salt Lake City,; 84132, USA.; The human immunodeficiency virus type 1 (HIV-1) matrix protein forms a structural shell associated with the inner viral membrane and performs other essential functions throughout the viral life cycle. The crystal structure of the HIV-1 matrix protein, determined at 2.3 angstrom resolution, reveals that individual matr
Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver.: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3126-31. Unique Identifier : AIDSLINE MED/96181547; Kollmann TR; Pettoello-Mantovani M; Katopodis NF; Hachamovitch M; Rubinstein A; Kim A; Goldstein H; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx NY 10461, USA.; To improve the usefulness of in vivo mode for the investigation of the pathophysiology of human immunodeficiency virus (HIV) infection, we modified the construction of SCID mice implanted with human fetal thymus and liver (thy/liv-SCID-hu mice) so that the peripheral blood of the mice contained significant numbers of
The need for epidemic intelligence.: Public Health Rep. 1996 Jan-Feb;111(1):26-31; discussion 32-3. Unique Identifier : AIDSLINE MED/96179071; Bloch AB; Onorato IM; Ihle WW; Hadler JL; Hayden CH; Snider DE Jr; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, GA 30333.; The past decade has witnessed an unprecedented upturn in tuberculosis morbidity and outbreaks of difficult- to-treat and highly lethal multidrug-resistant tuberculosis. In the early 1990s, a national consensus developed among public health officials to define more comprehensively the problem, and in January 1993, expa
Counseling and testing for HIV prevention: costs, effects, and cost-effectiveness of more rapid screening tests.: Public Health Rep. 1996 Jan-Feb;111(1):44-53; discussion 54. Unique Identifier : AIDSLINE MED/96179073; Farnham PG; Gorsky RD; Holtgrave DR; Jones WK; Guinan ME; Department of Economics, Georgia State University, Atlanta, GA; 30303.; New rapid human immunodeficiency virus (HIV) antibody tests permit many individuals to receive test results and appropriate counseling at one clinic visit. Because currently used tests require significant time for processing, all individuals must return for a second visit for test results and counseling. Since return
WHO's primer on AIDS [news]: Public Health Rep. 1996 Jan-Feb;111(1):7. Unique Identifier : AIDSLINE MED/96179083
Tuberculosis epidemic worldwide emergency [news]: Public Health Rep. 1996 Jan-Feb;111(1):8-9. Unique Identifier : AIDSLINE MED/96179084
Tuberculosis and HIV-AIDS [news]: Public Health Rep. 1996 Jan-Feb;111(1):9. Unique Identifier : AIDSLINE MED/96179085
AIDS and cerebrovascular disease.: Stroke. 1996 Mar;27(3):538-43. Unique Identifier : AIDSLINE MED/96175879; Pinto AN; Department of Epidemiology and Preventive Medicine, University of; Maryland at Baltimore, USA.; BACKGROUND: Although neurological complications of human immunodeficiency virus (HIV) infection are common, the presence of cerebrovascular disease (CVD) has been seldom reported. The purpose of this report is to review available data on the association between stroke and acquired immunodeficiency syndrome (AIDS). SUM
The effects of blood transfusion on cytokine production by TH1 and TH2 lymphocytes in the mouse.: Transplantation. 1996 Feb 15;61(3):465-8. Unique Identifier : AIDSLINE MED/96191037; Babcock GF; Alexander JW; Department of Surgery, University of Cincinnati Medical Center,; Ohio 45267-0558, USA.
Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance.: Virology. 1996 Mar 15;217(2):470-7. Unique Identifier : AIDSLINE MED/96183369; Rolph MS; Ramshaw IA; Rockett KA; Ruby J; Cowden WB; Division of Cell Biology, John Curtin School of Medical Research,; Canberra, Australia.; Recent reports have highlighted a potential antiviral activity for nitric oxide (NO). The purpose of this study was to investigate the production of NO in mice during vaccinia virus (VV) or herpes simplex virus type 1 infection, and to assess the role of NO in clearance of VV. Reactive nitrogen intermediates (RNI; NO
Production and characterization of high-titer stocks of rev-defective HIV-1.: Virology. 1996 Mar 15;217(2):602-6. Unique Identifier : AIDSLINE MED/96183384; Riggs NL; Guatelli JC; San Diego Veterans Affairs Medical Center, University of; California at San Diego, La Jolla 92093-0679, USA.; High-titer stocks of rev-defective HIV-1 virions have been produced and characterized. To produce these stocks, CEM cells transduced with a murine retroviral vector that expresses Rev were used to support the growth of an HIV-1 genome containing four inactivating mutations in the rev gene. The resulting viral stocks w
Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1.: Virology. 1996 Mar 15;217(2):613-7. Unique Identifier : AIDSLINE MED/96183386; Trujillo JR; Wang WK; Lee TH; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; Some neuronal-derived CD4-negative cells are susceptible to infection with human immunodeficiency virus type 1 (HIV-1). Galactosyl ceramide is an alternate receptor for HIV-1 that appears to bind in vitro to the C2, V3, V4, and V5 regions of gp120. Amino acid variation in the V3 loop of HIV-1 affects cellular tropism
The HTLV-1 Rex protein induces nuclear accumulation of unspliced viral RNA by avoiding intron excision and degradation.: Virology. 1996 Apr 15;218(2):316-25. Unique Identifier : AIDSLINE MED/96193743; Grone M; Koch C; Grassmann R; Institut fur Klinische und Molekulare Virologie der Universitat; Erlangen-Nurnberg, Germany.; The human T-cell leukemia virus (HTLV-1) Rex protein is essential for the cytoplasmic accumulation of incompletely spliced transcripts that code for the viral structural proteins. In this study effects of Rex on the amounts of total, spliced and unspliced RNA from HTLV-1 were determined. In transfected fibroblasts Rex
Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect.: Virology. 1996 Apr 15;218(2):326-34. Unique Identifier : AIDSLINE MED/96193744; Kewalramani VN; Park CS; Gallombardo PA; Emerman M; Fred Hutchinson Cancer Research Center, Division of Molecular; Medicine, Seattle, Washington 98104, USA.; Using recombinant proteins as standards, we calculated the amount of Vpr and Vpx present in HIV-2ROD particles. We find 2000-3000 copies of Vpx per particle but only 40-50 copies of Vpr. We investigated the reasons for this discrepancy between Vpx and Vpr and found that viral factors, including HIV-2 Vpx, do not restr
Sequence requirements of ATF2 and CREB binding to the human T-cell leukemia virus type 1 LTR R region.: Virology. 1996 Apr 15;218(2):362-71. Unique Identifier : AIDSLINE MED/96193748; Xu X; Kang SH; Heidenreich O; Brown DA; Nerenberg MI; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, California 92037, USA.; We have identified crucial transcription factor contact sites within the distal portion of the HTLV-1 LTR R region. Single base substitutions within this region greatly reduce formation of a complex which we previously described as a 70-kDa nuclear protein interacting with a CREB-like protein. Comparison of published
The amount of host HLA-DR proteins acquired by HIV-1 is virus strain- and cell type-specific.: Virology. 1996 Apr 15;218(2):372-81. Unique Identifier : AIDSLINE MED/96193749; Cantin R; Fortin JF; Tremblay M; Centre de Recherche en Infectiologie, Centre Hospitalier de; l'Universite Laval, Ste-Foy, Quebec, Canada.; We semiquantitatively monitored the incorporation of host membrane proteins on different strains of human immunodeficiency virus type 1 (HIV-1) grown in several human CD4+ lymphoid cell lines and in primary mitogen-stimulated peripheral blood mononuclear cells. The relative amounts of virally acquired cell proteins we
In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus saimiri: its susceptibility to infection with simian immunodeficiency viruses.: Virology. 1996 Apr 15;218(2):382-8. Unique Identifier : AIDSLINE MED/96193750; Akari H; Mori K; Terao K; Otani I; Fukasawa M; Mukai R; Yoshikawa Y; Tsukuba Primate Center for Medical Science, National Institute of; Health, Ibaraki, Japan.; Peripheral blood T lymphocytes of Old World monkeys, rhesus and cynomolgus monkey (Macaca mulatta and Macaca fascicularis, respectively), were successfully immortalized by infection with Herpesvirus saimiri subtype C. The T cell lines were stably cultured without addition of exogenous
Inhibition of HIV-1 in cell culture by synthetic humate analogues derived from hydroquinone: mechanism of inhibition.: Virology. 1996 Apr 15;218(2):389-95. Unique Identifier : AIDSLINE MED/96193751; Schneider J; Weis R; Manner C; Kary B; Werner A; Seubert BJ; Riede UN; Abteilung Virologie, Institut fur Medizinische Mikrobiologie und; Hygiene der Universitat, Freiburg, Germany.; Humic acids are natural constituents of soil and ground water and mainly consist of mixtures of polycyclic phenolic compounds. A similar complex of compounds with a mean size of about 1000 Da, designated HS-1500, was synthesized by oxidation of hydroquinone. HS-1500 inhibited HIV-1 infection of MT-2 cells with an IC50
Plasmacytoid CD8 lymphoma: morphologic and immunologic characterization.: Acta Haematol. 1995;94(4):204-9. Unique Identifier : AIDSLINE MED/96190623; Amiot L; Tas P; Caulet-Maugendre S; Goasguen J; Le Prise PY; Fauchet R; Drenou B; Laboratoire d'Hematologie-Immunologie, CHRU, Rennes, France.; This study describes a 79 year-old female suffering from fever and lymphadenopathy. A lymph node biopsy showed diffuse infiltration of medium-sized cells with plasmacytoid features. The immunologic phenotype determined by cytometric analysis and immunochemistry showed suppressor T antigen (CD2, CD3, CD7, CD8) expressi
T cell subsets in multiple sclerosis: a serial study.: Acta Neurol Scand. 1995 Nov;92(5):361-8. Unique Identifier : AIDSLINE MED/96191738; Calopa M; Bas J; Mestre M; Arbizu T; Peres J; Buendia E; Neurology Service, Ciutat Sanitaria Universitaria de Bellvitge,; Barcelona, Spain.; The relevance of abnormalities in the distribution of peripheral blood T lymphocyte subsets to the clinical manifestations of multiple sclerosis is not firmly established. A clinical and immunological follow-up of relapsing-remitting multiple sclerosis patients was performed in order to study the relationship of immun
MR appearances of the temporal evolution and resolution of infectious spondylitis.: AJR Am J Roentgenol. 1996 Apr;166(4):903-7. Unique Identifier : AIDSLINE MED/96198994; Gillams AR; Chaddha B; Carter AP; Department of Radiology, Boston University Medical School, MA; USA.; OBJECTIVE. We undertook this study to document the MR appearances of evolving or resolving infectious spondylitis. MATERIALS AND METHODS. A retrospective review was carried out of all patients with infectious spondylitis who had undergone MR imaging from 1991-1993 at Boston University Hospital and Boston City Hospital
Re: Determinants of HIV disease progression among homosexual men registered in the Tricontinental Seroconverter Study and Progression of human immunodeficiency virus type 1 (HIV-1) infection among homosexual men in hepatitis B vaccine trial cohorts in Amsterdam, New York City, and San Francisco, 1978-1991: [letter]: Am J Epidemiol. 1996 Mar 1;143(5):523-5; discussion 525-6. Unique Identifier : AIDSLINE MED/96199271; Zwahlen M; Vlahov D; Hoover DR
Projecting disease when death is likely.: Am J Epidemiol. 1996 May 1;143(9):943-52. Unique Identifier : AIDSLINE MED/96196613; Hoover DR; Peng Y; Saah AJ; Detels RR; Rinaldo CR Jr; Phair JP; Department of Epidemiology, Johns Hopkins University School of; Public Health, Baltimore, MD, USA.; Projection disease incidence, prevalence, and net morbidity is often needed when individuals are likely to die, either disease free or after the disease has developed. Examples of this include remission of cancer or heart disease in elderly people who can die from these or other causes and occurrence of a particular a
Psychopathology in women with HIV disease and drug abuse [letter]: Am J Psychiatry. 1996 Mar;153(3):448-9. Unique Identifier : AIDSLINE MED/96180629; Pergami A; Gala C
Esophageal ulcers in AIDS [letter; comment]: Ann Intern Med. 1996 May 15;124(10):928; discussion 928-9. Unique Identifier : AIDSLINE MED/96198458; Couderc LJ; Balloul E; Caubarrere I
Esophageal ulcers in AIDS [letter; comment]: Ann Intern Med. 1996 May 15;124(10):928; discussion 928-9. Unique Identifier : AIDSLINE MED/96198459; Domingo P; Ris J; Lopez-Contreras J
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study Group.: Ann Intern Med. 1996 May 1;124(9):792-802. Unique Identifier : AIDSLINE MED/96188893; Safrin S; Finkelstein DM; Feinberg J; Frame P; Simpson G; Wu A; Cheung T; Soeiro R; Hojczyk P; Black JR; San Francisco General Hospital, San Francisco, CA 94110.; OBJECTIVE: To compare the tolerability and efficacy of three oral regimens for the treatment of patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia. DESIGN: A randomized, double-blind study. SETTING: 24 U.S. academic medical centers. PATIENTS: 181 patients with morphologicall
Polymerase chain reaction for the diagnosis of HIV infection in adults. A meta-analysis with recommendations for clinical practice and study design.: Ann Intern Med. 1996 May 1;124(9):803-15. Unique Identifier : AIDSLINE MED/96188894; Owens DK; Holodniy M; Garber AM; Scott J; Sonnad S; Moses L; Kinosian B; Schwartz JS; Section of General Internal Medicine, Veterans Affairs Palo Alto; Health Care System, CA 94304 USA.; PURPOSE: To do a meta-analysis of studies that have evaluated the sensitivity and specificity of polymerase chain reaction (PCR) assay for the diagnosis of human immunodeficiency virus (HIV) infection in adults. Evaluating the performance of PCR is difficult because in certain clinical situations, the sensitivity or s
Hepatotoxicity and rash associated with zidovudine and zalcitabine chemoprophylaxis [letter]: Ann Intern Med. 1996 May 1;124(9):855. Unique Identifier : AIDSLINE MED/96208418; Henry K; Acosta EP; Jochimsen E
Inactivation of Th1 and Th2 cells by feeding ovalbumin.: Ann N Y Acad Sci. 1996 Feb 13;778:122-32. Unique Identifier : AIDSLINE MED/96177395; Mowat AM; Steel M; Worthey EA; Kewin PJ; Garside P; Department of Immunology, University of Glasgow, Scotland.; Several different mechanisms have been implicated in oral tolerance to protein antigens, depending on the nature and dose of antigen used and the species under study. Here, we have investigated the basis of unresponsiveness in a well-established model of oral tolerance in mice fed 25 mg ovalbumin (OVA). Our results sh
Intraocular inflammatory disease (uveitis) and the use of oral tolerance: a status report.: Ann N Y Acad Sci. 1996 Feb 13;778:325-37. Unique Identifier : AIDSLINE MED/96177414; Nussenblatt RB; Whitcup SM; de Smet MD; Caspi RR; Kozhich AT; Weiner HL; Vistica B; Gery I; Laboratory of Immunology, National Eye Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Intraocular inflammatory disease, or uveitis, is a disorder that mostly affects children and young adults. It is the cause of about 10% of the severe visual handicap in the United States . Many of the severe, sight-threatening uveitic conditions are thought to be driven by putative auto
Oral tolerance to insulin and the insulin B-chain: cell lines and cytokine patterns.: Ann N Y Acad Sci. 1996 Feb 13;778:346-57. Unique Identifier : AIDSLINE MED/96177416; Maron R; Blogg NS; Polanski M; Hancock W; Weiner HL; Center for Neurologic Diseases, Harvard Medical School, Boston,; Massachusetts 02115, USA.
Regulation of chemokine gene expression by contact hypersensitivity and by oral tolerance.: Ann N Y Acad Sci. 1996 Feb 13;778:434-7. Unique Identifier : AIDSLINE MED/96177441; Yuan YS; Major JA; Battisto JR; Department of Biology, Cleveland State University, Ohio 44195,; USA.; In mice with hapten-induced CH, T cells of the CD4+ and CD8+ phenotypes activated the gene for JE, whereas CD8+ T cells alone caused activation of the gene for IP-10. In animals tolerized by feeding either TNCB or OX, hapten-induced expression of IP-10 but not JE mRNA was lost. The down-regulation of IP-10 gene activa
The role of Th1 and Th2 cells for mucosal IgA responses.: Ann N Y Acad Sci. 1996 Feb 13;778:64-71. Unique Identifier : AIDSLINE MED/96177389; Yamamoto M; Vancott JL; Okahashi N; Marinaro M; Kiyono H; Fujihashi K; Jackson RJ; Chatfield SN; Bluethmann H; McGhee JR; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; We have used cytokine-knockout mice to help determine the precise requirements for CD4+ Th cell regulation of IgA responses. In these studies, we have used two different oral delivery systems to induce mucosal and systemic antibody responses to the vaccine TT. In normal mice, oral administration of TT with CT as adjuv
In vitro synthesis of an N-myristoylated fusion protein that binds to the liposomal surface.: Arch Biochem Biophys. 1996 Feb 15;326(2):179-84. Unique Identifier : AIDSLINE MED/96190642; Utsumi T; Kuranami J; Tou E; Ide A; Akimaru K; Hung MC; Klostergaard J; Department of Biological Chemistry, Faculty of Agriculture,; Yamaguchi University, Japan.; To increase the efficiency of association of tumor necrosis factor (TNF), a hydrophilic model protein, with liposomes, an N-myristoylation signal sequence was linked to the N-terminus of TNF by gene fusion. A DNA sequence coding for the N-myristoylation signal of Rasheed leukemia virus-gag protein was fused to be 5 -e
Bone allograft banking in South Australia.: Aust N Z J Surg. 1995 Dec;65(12):865-9. Unique Identifier : AIDSLINE MED/96203022; Campbell DG; Oakeshott RD; University Department of Orthopaedic and Trauma Surgery, Royal; Adelaide Hospital, Australia.; The South Australian Bone Bank had expanded to meet an increased demand for allograft bone. During a 5 year period from 1988 to 1992, 2361 allografts were harvested from 2146 living donors and 30 cadaveric donors. The allografts were screened by contemporary banking techniques which include a social history, donor ser
[The health care problems of planning services in a sample of persons with AIDS in Naples]: Ann Ig. 1994 Jul-Dec;6(4-6):399-407. Unique Identifier : AIDSLINE MED/96187972; Marazzi MC; Mancinelli S; Palombi L; Liotta G; Chirianni A; Liuzzi G; Paone G; Manzillo E; Maio G; Soscia E; et al; Universita Maria SS Assunta (LUMSA), Roma.
[The sexual transmission of the acquired immunodeficiency virus: the reasons for greater male-to-female than female-to-male transmission efficiency]: Ann Ig. 1994 Jul-Dec;6(4-6):641-8. Unique Identifier : AIDSLINE MED/96188000; Nicolosi A; Autelitano M; Correa Leite ML; Osella AR; Lazzarin A; Ist. di Tecnologie Biomediche Avanzate, Consiglio Nazionale delle; Ricerche, Milano.
Correlates of HIV infection knowledge in samples of Italian young population.: Ann Ig. 1994 Jul-Dec;6(4-6):699-708. Unique Identifier : AIDSLINE MED/96188006; Cattaruzza MS; Zantedeschi E; Signorelli C; Guasticchi G; Osborn JF; Ist. di Igiene G. Sanarelli, Universita degli Studi di Roma La; Sapienza.
[Use of the condom for the prevention of AIDS: a review of 10 studies from Europe and the United States]: Ann Ig. 1994 Jul-Dec;6(4-6):709-16. Unique Identifier : AIDSLINE MED/96188007; Zantedeschi E; Bossi A; Cattaruzza MS; Carlucci M; Ist. di Igiene G. Sanarelli, Universita degli Studi di Roma La; Sapienza.
[The level of information on AIDS among the university and secondary school students of Camerino]: Ann Ig. 1994 Jul-Dec;6(4-6):717-21. Unique Identifier : AIDSLINE MED/96188008; Grappasonni I; Petrelli F; Cocchioni M; Troiani P; Pellegrini MG; Zanetti AR; Dip. di Scienze Igienistiche e Sanitarie-Ambientali, Universita; di Camerino.
Recent increase in the incidence of non-Hodgkin's lymphoma among young men and women in Denmark.: Br J Cancer. 1996 Apr;73(7):951-4. Unique Identifier : AIDSLINE MED/96192192; Hjalgrim H; Frisch M; Begtrup K; Melbye M; Danish Epidemiology Science Centre, Statens Seruminstitut,; Copenhagen, Denmark.; Time-related trends in the incidence of non-Hodgkin s lymphoma (NHL) in Denmark were analysed for the period 1943-89. A total of 13 822 patients (7565 men and 6257 women) were included in the stu
Efficacy and safety of Stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma. The International SL-DOX Study Group.: Br J Cancer. 1996 Apr;73(8):989-94. Unique Identifier : AIDSLINE MED/96200418; Goebel FD; Goldstein D; Goos M; Jablonowski H; Stewart JS; Poliklinik der Universitat Munich, Germany.; The utility of current chemotherapeutic regimens in the treatment of AIDS-related Kaposi s sarcoma (AIDS-KS) is often compromised by both limited efficacy and substantial toxicity. Pegylated (Stealth) liposomal doxorubicin hydrochloride (SL-DOX) has been demonstrated specifically to deliver high concentrations of doxo
Nasopharyngeal carcinoma: an EBV-associated tumour not significantly influenced by HIV-induced immunosuppression. The AIDS/Cancer Working Group.: Br J Cancer. 1996 Apr;73(8):995-7. Unique Identifier : AIDSLINE MED/96200419; Melbye M; Cote TR; West D; Kessler L; Biggar RJ; Danish Epidemiology Science Center, Statens Serum Institut,; Copenhagen, Denmark.; We used a link between cancer (859,398 reports) and AIDS (50,050 reports) registries in the United States to study whether nasopharyngeal carcinoma (NPC) was increased in the population with AIDS. There was no indication of a significantly increased risk up to or after the AIDS diagnos
Macrophages are the major target cell for HIV infection in long-term marrow culture and demonstrate dual susceptibility to lymphocytotropic and monocytotropic strains of HIV-1.: Br J Haematol. 1996 Apr;93(1):30-7. Unique Identifier : AIDSLINE MED/96200428; Gill V; Shattock RJ; Freeman AR; Robinson G; Griffin GE; Gordon-Smith EC; Gibson FM; Department of Cellular and Molecular Sciences, St. George's; Hospital Medical School, London.; Haematological abnormalities are often seen in patients infected with HIV. A number of mechanisms are thought to contribute to this bone marrow suppression, including impaired stromal function and direct infection of progenitor cells. Evidence suggests that both bone marrow progenitor cells and perhaps stromal cells a
Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF.: Biochemistry. 1996 Apr 23;35(16):5158-65. Unique Identifier : AIDSLINE MED/96196621; Vu HM; de Lorimier R; Moody MA; Haynes BF; Spicer LD; Department of Biochemistry, Duke University Medical Center,; Durham, North Carolina 27710, USA.; A critical problem to overcome on HIV vaccine design is the variability among HIV strains. One strategy to solve this problem is the construction of multicomponent immunogens reflective of common HIV motifs. Currently, it is not known if these motifs should be based primarily on amino acid sequence or higher-order str
Zinc binding to the HIV-1 nucleocapsid protein: a thermodynamic investigation by fluorescence spectroscopy.: Biochemistry. 1996 Apr 23;35(16):5175-82. Unique Identifier : AIDSLINE MED/96196623; Mely Y; De Rocquigny H; Morellet N; Roques BP; Gerad D; Laboratoire de Biophysique, URA 491 du CNRS, Faculte de; Pharmacie de Strasbourg I, B.P. 24, Illkirch, France.; The HIV-1 nucleocapsid protein, NCp7, is characterized by two CCHC zinc finger motifs which have been shown to stoichiometrically bind zinc in mature virions. Moreover, this binding of zinc proves to be critical in various NCp7 functions, especially in the encapsidation process. To further understand the central role
Incorporation of a non-nucleotide bridge into hairpin oligonucleotides capable of high-affinity binding to the Rev protein of HIV-1.: Biochemistry. 1996 Apr 23;35(16):5339-44. Unique Identifier : AIDSLINE MED/96196644; Nelson JS; Giver L; Ellington AD; Letsinger RL; Department of Chemistry, Northwestern University, Evanston,; Illinois 60208, USA.; A bridge containing a rigid trans-stilbene group, P(O)(O-)O(CH2)3NHC(O)- C6H4-CH=CHC6H4C(O)NH(CH2)3OP(O)(O-)-, has been incorporated into several oligonucleotide sequences based on the minimal Rev Binding Element (RBE) of HIV-1. This bridge was found to be effective as a UUCG tetraloop in stabilizing short RNA duplex
Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein.: Biochim Biophys Acta. 1996 Apr 10;1306(1):9-13. Unique Identifier : AIDSLINE GENBANK/U25801; Mireskandari A; Reid RL; Kashanchi F; Dittmer J; Li WB; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA.; Tax1 is essential for human T-cell lymphotropic virus type I (HTLV-I) virus replication and transformation. We have identified and characterized a Tax1 binding protein, TRX, by cDNA screening of a Jurkat T-cell cDNA library. TRX mRNA is ubiquitously expressed in human tissues tested and cell lines analyzed.
Neopterin and beta 2-microglobulin as serum markers in a placebo-controlled anti-HIV therapy trial.: Eur J Clin Chem Clin Biochem. 1995 Sep;33(9):559-62. Unique Identifier : AIDSLINE MED/96187111; Carstens J; Teglbjaerg LS; Black FT; Department of Infectious Diseases, Marselisborg Hospital,; University Hospital, Aarhus, Denmark.; The purpose of this study was to evaluate the use of the biologic immune activation markers neopterin and beta 2-microglobulin in monitoring human immunodeficiency virus (HIV)-positive patients without acquired immunodeficiency syndrome (AIDS) treated with isoprinosine and placebo. Serum samples obtained at the commen
Human herpesvirus-8 DNA sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity.: Blood. 1996 May 1;87(9):3903-9. Unique Identifier : AIDSLINE MED/96199431; Luppi M; Barozzi P; Maiorana A; Artusi T; Trovato R; Marasca R; Savarino M; Ceccherini-Nelli L; Torelli G; Department of Medical Sciences, University of Modena, Italy.; Human herpesvirus-8 (HHV-8) DNA sequences have been reported to be strictly associated not only with various forms of Kaposi s sarcoma but also with an unusual subgroup of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphomas. A possible relation of this putative virus also with multicentric Castleman s d
Alpha s1-casein-specific CD8+ T cell clone that inhibits its own interferon-gamma production by producing interleukin-10.: Biosci Biotechnol Biochem. 1995 Dec;59(12):2274-6. Unique Identifier : AIDSLINE MED/96187587; Nishijima K; Hisatsune T; Kato H; Shiho O; Kaminogawa S; Department of Applied Biological Chemistry, University of Tokyo,; Japan.; A CD8+ T cell clone specific to alpha s1-casein, one of the major allergens in milk, is shown to inhibit its own production of interferon (IFN)-gamma by producing interleukin (IL)-10. Anti-IL-10 antibodies enhanced the production of IFN-gamma induced by the antigen plus antigen-presenting cells from 12 h onward after
Concerns about AIDS in general practice.: BMJ. 1996 Feb 3;312(7026):285-6. Unique Identifier : AIDSLINE MED/96190112; Moons MA; Peters L; Bartelds AI; Kerssens JJ; Netherlands Institute of Primary Health Care, Utrecht,; Netherlands.
French AIDS group criticises treatment of immigrants [news]: BMJ. 1996 Feb 10;312(7027):331-2. Unique Identifier : AIDSLINE MED/96190152; Dorozynski A
Disease in children infected with HIV in Abidjan, Cote d'Ivoire.: BMJ. 1996 Feb 10;312(7027):335-8. Unique Identifier : AIDSLINE MED/96190156; Lucas SB; Peacock CS; Hounnou A; Brattegaard K; Koffi K; Honde M; Andoh J; Bell J; De Cock KM; Department of Histopathology, University College London Medical; School.; OBJECTIVE--To document the range of disease in African children infected with HIV. DESIGN--Necropsy results in consecutive children aged 1 month or more who were HIV positive and in children who were HIV negative for comparison; IgA western blots on serum samples from children under 2 years of age who were positive fo
Recent advances in obstetrics. Transmission of HIV from mother to infant depends on many factors [letter; comment] [see comments]: BMJ. 1996 Feb 10;312(7027):379-80. Unique Identifier : AIDSLINE MED/96190182; Berer M
[The condom. A little known product in 1995]: Contracept Fertil Sex. 1996 Feb;24(2):117-22. Unique Identifier : AIDSLINE MED/96203129; Janaud A
[Attitudes to counseling related to HIV infection screening in Bobo-Dioulasso, Burkina Faso]: Sante. 1996 Jan-Feb;6(1):7-10. Unique Identifier : AIDSLINE MED/96205119; Cartoux M; Rouamba O; Meda N; Dabis F; Durand G; Salamon R; Universite de Bordeaux II, Inserm U 330, France.; Two approaches, a questionnaire administered to pregnant women and interviews independently with selected individuals in posts of responsibility, were used to assess (i) the perception of HIV screening among patients attending a Maternal and Child Health Clinic and (ii) the attitudes of health staff and local authorit
Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary to human immunodeficiency virus.: Bioorg Med Chem. 1995 Jan;3(1):49-54. Unique Identifier : AIDSLINE MED/96214696; Kim SG; Hatta T; Tsukahara S; Nakashima H; Yamamoto N; Shoji Y; Takai K; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.; Modifications of oligodeoxyribonucleotides include the replacement of the backbone phosphodiester groups with phosphorothioate (S-ODNs) groups and the substitution of phosphorothioate (SO-ODNs) groups at both the 3 - and 5 -ends. In assays for HIV, oligomers (S-ODNs) were more active at the micromolar range than were
Management of adverse reactions to prophylactic trimethoprim-sulfamethoxazole in patients with human immunodeficiency virus infection.: Ann Allergy Asthma Immunol. 1996 Apr;76(4):355-8. Unique Identifier : AIDSLINE MED/96189193; Belchi-Hernandez J; Espinosa-Parra FJ; Virgen del Rossell Hospital, Department of Allergy and Internal; Medicine, Murcia, Spain.; BACKGROUND: In hospitals attended by patients with human immunodeficiency virus infection, adverse reactions are often observed to trimethoprim-sulfamethoxazole, particularly cutaneous reactions. Given the importance of this drug for prophylaxis we have attempted to establish a desensitization or tolerance protocol so
IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels.: Immunity. 1996 Apr;4(4):329-36. Unique Identifier : AIDSLINE MED/96200886; Tagaya Y; Bamford RN; DeFilippis AP; Waldmann TA; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland 20892, USA.
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.: Immunity. 1996 Apr;4(4):397-405. Unique Identifier : AIDSLINE MED/96200893; Hodge MR; Ranger AM; Charles de la Brousse F; Hoey T; Grusby MJ; Glimcher LH; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; NF-ATp is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In this study, we show that mice with a null mutation in the NF-ATp gene have splenomegaly with hyperproliferation of both B and T cells. They also display early defects in the transcripti
Low copy number and limited variability of proviral DNA in alveolar macrophages from HIV-1-infected patients: evidence for genetic differences in HIV-1 between lung and blood macrophage populations.: Mol Med. 1995 Nov;1(7):744-57. Unique Identifier : AIDSLINE MED/96192943; Nakata K; Weiden M; Harkin T; Ho D; Rom WN; Division of Pulmonary and Critical Care Medicine, New York; University Medical Center, New York, USA.; BACKGROUND: We investigated the human immunodeficiency virus (HIV) proviral DNA sequence and copy number in alveolar macrophages (AM) and peripheral blood monocytes (PBM) from 10 HIV-positive patients without any active concurrent pulmonary disease to understand the nature of HIV-1 infection in vivo in the lung microe
Compounds that target novel cellular components involved in HIV-1 transcription.: Mol Med. 1995 Nov;1(7):758-67. Unique Identifier : AIDSLINE MED/96192944; Butera ST; Roberts BD; Critchfield JW; Fang G; McQuade T; Gracheck SJ; Folks TM; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; BACKGROUND: Therapeutic intervention designed to block expression of human immunodeficiency virus (HIV) at a cellular level may slow the clinical progression of HIV-1 disease. MATERIALS AND METHODS: Cellular models of latent (OM-10.1 and U1) and chronic (8E5) HIV infection were used to evaluate two benzothiophene deri
Local expansion of allergen-specific CD30+Th2-type gamma delta T cells in bronchial asthma.: Mol Med. 1995 Nov;1(7):821-6. Unique Identifier : AIDSLINE MED/96192950; Spinozzi F; Agea E; Bistoni O; Forenza N; Monaco A; Falini B; Bassotti G; De Benedictis F; Grignani F; Bertotto A; Department of Internal Medicine, University of Perugia School of; Medicine, Policlinico Monteluce, Italy.; BACKGROUND: T lymphocytes infiltrating airways during the allergic immune response play a fundamental role in recruiting other specialized cells, such as eosinophils, by secreting interleukin 5 (IL-5), and promoting local and systemic IgE synthesis by producing IL-4. Whether these presumed allergen-specific T cells ar
AIDS -- a treatable disease at last [editorial]: Nat Med. 1996 Mar;2(3):253. Unique Identifier : AIDSLINE MED/96197710; Culliton BJ
Saquinavir: too early to market? [news]: Nat Med. 1996 Mar;2(3):257. Unique Identifier : AIDSLINE MED/96197716; Steele FR
Optimism invades HIV conference [news]: Nat Med. 1996 Mar;2(3):257-8. Unique Identifier : AIDSLINE MED/96197715; Steele FR
Boboon graft fails, but patient thrives [news]: Nat Med. 1996 Mar;2(3):259. Unique Identifier : AIDSLINE MED/96197717; Taylor R
Closing in on human immunodeficiency virus-1 [see comments]: Nat Med. 1996 Mar;2(3):274-5. Unique Identifier : AIDSLINE MED/96197722; Mellors JW; University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Human herpesvirus 8 in lymphoma and Kaposi's sarcoma: now the virus can be propagated.: Nat Med. 1996 Mar;2(3):277-8. Unique Identifier : AIDSLINE MED/96197724; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
Auxotrophic vaccines for tuberculosis.: Nat Med. 1996 Mar;2(3):334-7. Unique Identifier : AIDSLINE MED/96197737; Guleria I; Teitelbaum R; McAdam RA; Kalpana G; Jacobs WR Jr; Bloom BR; Howard Hughes Medical Institute, Bronx, New York 10461, USA.; Tuberculosis is responsible for the deaths of more people each year than any other single infectious disease, with greater than 7 million new cases and 2 million deaths annually. It remains the largest attributable cause of death in HIV-infected individuals, responsible for 32% of deaths of HIV-infected individuals in
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein.: Nat Med. 1996 Mar;2(3):338-42. Unique Identifier : AIDSLINE MED/96197738; Schwartz O; Marechal V; Le Gall S; Lemonnier F; Heard JM; Laboratoire Retrovirus et Transfert Genetique, Unite de; Recherche Associee CNRS 1157, Paris, France.; Like other pathogenic viruses, HIV-1 down-modulates surface expression of major histocompatibility complex class I (MHC-I) molecules in infected cells, thus impairing lysis by cytotoxic T lymphocytes. We have observed that this phenomenon depends on the expression of Nef. nef is an early gene of primate lentiviruses,
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.: Nat Med. 1996 Mar;2(3):342-6. Unique Identifier : AIDSLINE MED/96197739; Renne R; Zhong W; Herndier B; McGrath M; Abbey N; Kedes D; Ganem D; Howard Hughes Medical Institute, San Francisco, California 94143,; USA.; Kaposi s sarcoma (KS) is the leading neoplasm of AIDS patients, and HIV infection is known to be a major risk factor for its development. However, KS can occur in the absence of HIV infection and the risk of KS development varies widely even among HIV-infected patients, with homosexual men with AIDS being 20 times mor
Specific tolerization of active cytolytic T lymphocyte responses in vivo with soluble peptides.: Cell Immunol. 1996 Apr 10;169(1):16-23. Unique Identifier : AIDSLINE MED/96185988; Duarte EA; Eberl G; Corradin G; Institute of Biochemistry, University of Lausanne, Epalinges,; Switzerland.; A promising approach toward preventing and treating autoimmune disease involves identifying the mediating antigen and then tolerizing the autoreactive T cells with the corresponding antigen. For success, this method will require the specific tolerization of active helper or CTL responses while maintaining the integrit
Adoptive transfer of resistance to murine retrovirus-induced immune suppression.: Cell Immunol. 1996 Apr 10;169(1):24-9. Unique Identifier : AIDSLINE MED/96185989; Gilmore GL; Department of Immunology, Medical Biology Institute, La Jolla,; California, USA.; Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d
HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors.: Cell Immunol. 1996 Apr 10;169(1):40-6. Unique Identifier : AIDSLINE MED/96185991; Patki AH; Lederman MM; Department of Medicine, Case Western Reserve University School of; Medicine, Cleveland, Ohio 44106, USA.; To explore further the effects of the HIV-1 transactivator protein Tat on human lymphoid cell function we examined the effects of Tat on lymphocyte proliferation and programmed cell death (apoptosis). We found that the HIV-1 Tat protein induced apoptosis and inhibited lymphocyte proliferative responses in lymphocytes
Hematologic malignancies during pregnancy.: Clin Obstet Gynecol. 1995 Sep;38(3):535-46. Unique Identifier : AIDSLINE MED/96203350; Sadural E; Smith LG Jr; Department of Obstetrics and Gynecology, Saint Barnabas Medical; Center, Livingston, New Jersey 07039, USA.; Most hematologic malignancies are rare during the childbearing years with the exception of Hodgkin s lymphoma. However, the continued spread of retroviruses, such as human immunodeficiency virus, in the heterosexual population may result in a substantial rise in viral-induced non-Hodgkin s lymphomas. Although pregnanc
Gene therapy. Clinical potential and relationship to drug treatment.: Drugs. 1995 Dec;50(6):951-8. Unique Identifier : AIDSLINE MED/96191573; Whartenby KA; Marrogi AJ; Freeman SM; Center for Biologics, Food and Drug Administration, Rockville,; Maryland, USA.
Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry.: Endocrinology. 1996 May;137(5):1719-26. Unique Identifier : AIDSLINE MED/96198768; Gagnerault MC; Postel-Vinay MC; Dardenne M; CNRS URA 1461, Universite Paris V, Hopital Necker, France.; We have analyzed the expression of GH receptors (GHR) in murine lymphoid organs using flow cytofluorometry with biotinylated bovine GH and specific fluorescein isothiocyanate-labeled monoclonal antibodies defining distinct lymphoid cell populations. GHR were widely expressed in al murine hematopoietic tissues and in f
The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptide.: EMBO J. 1996 Apr 1;15(7):1507-14. Unique Identifier : AIDSLINE MED/96203067; Weissenhorn W; Wharton SA; Calder LJ; Earl PL; Moss B; Aliprandis E; Skehel JJ; Wiley DC; Laboratory of Molecular Medicine, Howard Hughes Medical; Institute, Children's Hospital, Boston, MA 02215, USA.; The human immunodeficiency virus-1 (HIV-1) envelope glycoprotein is composed of a soluble glycopolypeptide gp120 and a transmembrane glycopolypeptide gp41. These subunits form non-covalently linked oligomers on the surface of infected cells, virions and cells transfected with the complete env gene. Two length variants
HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.: EMBO J. 1996 Apr 1;15(7):1607-14. Unique Identifier : AIDSLINE MED/96203078; Suzuki T; Kitao S; Matsushime H; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.; Tax, a regulatory protein of human T-cell leukemia virus type 1 (HTLV-1), is an oncoprotein which immortalizes human T cells and induces tumors in transgenic mice. These effects may be due to its interaction with cellular proteins, consisting of several transcription factors including CREB, NF-kappa B and SRF, and the
Synergistic enhancement of both initiation and elongation by acidic transcription activation domains.: EMBO J. 1996 Apr 1;15(7):1658-65. Unique Identifier : AIDSLINE MED/96203084; Blair WS; Fridell RA; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710, USA.; The effects of activation domain synergy on transcription initiation and elongation have been examined utilizing a system that permits the targeting of a defined number of activation modules to promoter DNA. As predicted, incremental increases in targeted activation potential were found to result in corresponding incr
Propolis protects against doxorubicin-induced myocardiopathy in rats.: Exp Mol Pathol. 1995 Jun;62(3):190-8. Unique Identifier : AIDSLINE MED/96198836; Chopra S; Pillai KK; Husain SZ; Giri DK; Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard; (Hamdard University), New Delhi, India.; Propolis (bee glue) is one of the major hive products of bees and is rich in flavonoids, which are known for antioxidant activities. Doxorubicin-induced myocardiopathy is the consequence of oxidative stress through the mediation of free radicals. The effect of intraperitoneal administration of propolis (50 and 100 mg/
Transduction signals induced in rat brain cortex astrocytes by the HIV-1 gp120 glycoprotein.: FEBS Lett. 1996 Apr 15;384(2):135-7. Unique Identifier : AIDSLINE MED/96201952; Codazzi F; Racchetti G; Grohovaz F; Meldolesi J; Department of Pharmacology, University of Milano, Italy.; Cultures of rat brain cortex astrocytes were exposed to 10(-10)-10(-9)M of the HIV-1 envelope glycoprotein, gp120. No specific binding was revealed by the iodinated protein, suggesting expression of only a few sites onto the cells. In contrast, two transduction signals were rapidly induced by gp120: increased tyrosine
Are we playing to win or playing to keep from losing? [editorial]: Dent Econ. 1995 Oct;85(10):24, 27, 29-30 passim. Unique Identifier : AIDSLINE MED/96209527; Kennedy JL
Weight loss in acquired immunodeficiency syndrome: wasting or wanting not?: Gastroenterology. 1996 Apr;110(4):1316-7. Unique Identifier : AIDSLINE MED/96183173; Koretz RL
Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients.: Gastroenterology. 1996 May;110(5):1368-78. Unique Identifier : AIDSLINE MED/96200520; Maiuri L; Picarelli A; Boirivant M; Coletta S; Mazzilli MC; De Vincenzi M; Londei M; Auricchio S; Children's Hospital Pausilipon, Naples, Italy.; BACKGROUND & AIMS: Mucosal cell-mediated immune response is considered the central event in the pathogenesis of celiac disease. In cultured intestinal explants from celiacs in remission, we have characterized the early stages of gliadin-induced immune activation. METHODS: Intestinal biopsy specimens (15 treated cel
Long-term survival of patients with HIV-related systemic non-Hodgkin's lymphomas.: Hematol Oncol. 1996 Mar;14(1):7-15. Unique Identifier : AIDSLINE MED/96200803; Tirelli U; Errante D; Spina M; Vaccher E; Serraino D; Boiocchi M; Gloghini A; Carbone A; Division of Medical Oncology and AIDS, Centro di Riferimento; Oncologico, Aviano, Italy.; BACKGROUND: the overall outcome of patients with HIV-related non-Hodgkin s lymphomas (HIV-NHL) is poor because of the adverse clinico-pathological features of HIV-NHL and the underlying HIV infection. However, the experience of physicians in the management of HIV-NHL has increased, in particular in the use of intensiv
Identical genetic control of MLC reactivity to different MHC incompatibilities, independent of production of and response to IL-2.: Immunogenetics. 1996;44(1):27-35. Unique Identifier : AIDSLINE MED/96217553; Holan V; Lipoldova M; Demant P; Institute of Molecular Genetics, Academy of Sciences of the Czech; Republic, Prague, Czech Republic.; The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 tha
Genetic variability of the human CD4 V2 domain.: Immunogenetics. 1996;44(1):70-2. Unique Identifier : AIDSLINE GENBANK/U40625; Indraccolo S; Mion M; Biagiotti R; Romagnani S; Morfini M; Longo G; Zamarchi R; Chieco-Bianchi L; Amadori A; Institute of Oncology, University of Padova, Padova, Italy.
Autopsy report of a case of perinatal AIDS.: Indian J Pathol Microbiol. 1994 Dec;37 Suppl:S24-5. Unique Identifier : AIDSLINE MED/96188077; Lanjewar DN; Maheshwari MB; Khanna SA; Department of Pathology, Grant Medical College, Bombay.
Pediatric HIV infection: recent advances [editorial]: Indian Pediatr. 1995 May;32(5):519-27. Unique Identifier : AIDSLINE MED/96191442; Sen S
Pediatric AIDS.: Indian Pediatr. 1995 May;32(5):573-4. Unique Identifier : AIDSLINE MED/96191450; Patil P; Shenoy V; Department of Pediatrics, Kasturba Medical College, Manipal,; Karnataka.
HIV serosurveillance--report from a medical college in Delhi [letter]: Indian Pediatr. 1995 May;32(5):605-6. Unique Identifier : AIDSLINE MED/96191459; Mondal T; Kumar KJ; Malhotra VL
Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.: Infect Immun. 1996 May;64(5):1516-25. Unique Identifier : AIDSLINE MED/96201556; Okahashi N; Yamamoto M; Vancott JL; Chatfield SN; Roberts M; Bluethmann H; Hiroi T; Kiyono H; McGhee JR; Mucosal Immunization Research Group, University of Alabama,; Birmingham Medical Center 35294, USA.; Mucosal immunoglobulin A (IgA) responses are often associated with Th2-type cells and derived cytokines, and interleukin-4 (IL-4) knockout (IL-4-/-) mice with impaired Th2 cells respond poorly to oral antigens. However, we have noted that IL-4-/- mice have normal mucosal IgA levels, which led us to query whether diffe
A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness.: Infect Immun. 1996 May;64(5):1750-5. Unique Identifier : AIDSLINE MED/96201588; Cai Y; Langley JG; Smith DI; Boros DL; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; In schistosomiasis mansoni, soluble egg antigens of the worm induce chronic T-cell-mediated granulomatous tissue responses. Since the first preparation of crude soluble egg antigen extract, a dearth of highly purified antigens has hampered the identification of granuloma inducer molecules. Here we report that a cloned
Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.: Infect Immun. 1996 May;64(5):1870-2. Unique Identifier : AIDSLINE MED/96201608; Zwickey HL; Potter TA; Department of Medicine, National Jewish Center for Immunology and; Respiratory Medicine, Denver, CO 80206-2761, USA.; Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p
Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I.: Jpn J Cancer Res. 1996 Mar;87(3):227-31. Unique Identifier : AIDSLINE MED/96200929; Higashimura N; Takasawa N; Tanaka Y; Nakamura M; Sugamura K; Department of Microbiology, Tohoku University School of Medicine,; Sendai.; gp34, which we had identified as a target molecule of the trans-activation by Tax of human T-cell leukemia virus type I (HTLV-I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but
Distinct rate and patterns of human CD4+ T-cell depletion in hu-PBL-SCID mice infected with different isolates of the human immunodeficiency virus.: J Clin Immunol. 1995 Nov;15(6 Suppl):130S-133S. Unique Identifier : AIDSLINE MED/96191597; Mosier DE; Department of Immunology, Scripps Research Institute, La Jolla,; California 93037, USA.; The most fundamental question about infection with the human immunodeficiency virus is the mechanism by which infection leads to depletion of CD4+ T lymphocytes, a critical cell type for the regulation of both cellular and humoral immunity. We have studied this issue using a unique small-animal model that is highly su
The HIV-1 reservoir in distinct V beta subsets of CD4 T cells: evidence for a putative superantigen.: J Clin Immunol. 1995 Nov;15(6 Suppl):18S-21S. Unique Identifier : AIDSLINE MED/96191583; Posnett DN; Kabak S; Dobrescu D; Hodtsev AS; Department of Medicine, Cornell University Medical College, New; York, New York, USA.; Human immunodeficiency virus-1 (HIV-1) replicates more efficiently in T cells expressing T-cell receptors using certain V beta genes, V beta 12 in particular. This V beta specificity was consistent with an HIV-1-associated superantigen. In addition, T cell-depleted peripheral blood mononuclear cells from HIV-positive
Effect of anti-interleukin 12 treatment on murine lyme borreliosis.: J Clin Invest. 1996 Feb 15;97(4):1028-34. Unique Identifier : AIDSLINE MED/96193886; Anguita J; Persing DH; Rincon M; Barthold SW; Fikrig E; Section of Rheumatology, Yale Univerisity School of Medicine, New; Haven, Connecticut 06520-8031, USA.; The effect of anti-interleukin (IL-12 treatment on Lyme borreliosis in C3H/HeN (C3H) mice was assessed because other studies have implicated CD4+ T cell helper (Th) type 1 responses in the genesis of disease caused by Borrelia burgdorferi. Infection of inbred mice with B. burgdorferi results in varying degrees of arth
Hygienic maintenance of dental handpieces and turbines.: J Dent Assoc S Afr. 1995 Sep;50(9):416-7. Unique Identifier : AIDSLINE MED/96213555; Bossmann K
Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study.: J Allergy Clin Immunol. 1996 Mar;97(3):828-37. Unique Identifier : AIDSLINE MED/96213657; Thepen T; Langeveld-Wildschut EG; Bihari IC; van Wichen DF; van Reijsen FC; Mudde GC; Bruijnzeel-Koomen CA; Department of Dermatology/Allergology, University Hospital; Utrecht, The Netherlands.; In the pathogenesis of atopic dermatitis (AD), IgE plays an important role; and TH2 cells, producing IL-4, have been ascribed a key role in allergic diseases such as AD. To investigate the role of TH subpopulations in the onset and continuation of AD, we performed atopy patch tests (APTs) with house dust mite allergen
Transmission of HIV-1 in the breast-feeding process.: J Am Diet Assoc. 1996 Mar;96(3):267-74; quiz 275-6. Unique Identifier : AIDSLINE MED/96197977; Black RF; Augusta Nutrition Consultants, Augusta, Georgia, USA.; Current laboratory techniques cannot distinguish the mode of vertical transmission (intrauterine, intrapartum, or postnatal) of human immunodeficiency virus type 1 (HIV-1) from mother to infant. The ability to transmit HIV-1 via breast feeding has been established in 24 case reports, primarily involving mothers who se
Dendritic cells from different tissues induce production of different T cell cytokine profiles.: J Leukoc Biol. 1996 Apr;59(4):494-8. Unique Identifier : AIDSLINE MED/96201616; Everson MP; McDuffie DS; Lemak DG; Koopman WJ; McGhee JR; Beagley KW; Department of Medicine, University of Alabama at Birmingham, USA.; The precise role of antigen-presenting cells (APC) in regulating the balance of T-helper type 1 (Th1) and T-helper type 2 (Th2) cytokine production is unclear. Dendritic cells (DC), the most potent APC for activation of naive T cells, were found to regulate Th1 and Th2 cytokine profiles in a fashion dependent upon the
The CD4/CD8 ratio in the blood does not reflect the response of this index in secondary lymphoid organs of weanling mice in models of protein-energy malnutrition known to depress thymus-dependent immunity.: J Nutr. 1996 Apr;126(4):849-59. Unique Identifier : AIDSLINE MED/96182372; Lee WH; Woodward BD; Department of Human Biology and Nutritional Sciences, University; of Guelph, Ontario, Canada.; A low ratio of cellular numbers within CD4+ (helper/inducer) relative to CD8+ (suppressor/cytotoxic) thymic lymphocyte subsets (low CD4/CD8 ratio) is widely accepted as fundamental to the depression in thymus-dependent immunocompetence associated with wasting protein-energy malnutrition (PEM). The objective of this in
Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.: J Pharmacol Exp Ther. 1996 Apr;277(1):423-31. Unique Identifier : AIDSLINE MED/96185105; Kumar GN; Rodrigues AD; Buko AM; Denissen JF; Department of Biotransformation, Pharmaceutical Products; Division, Abbott Laboratories, Abbott Park, Illinois, USA.; The HIV-1 protease inhibitor ritonavir (ABT-538) undergoes cytochrome P450-mediated biotransformation in human liver microsomes to three major metabolites, Ml, M2 and M11, with wide interindividual variation in the rates of metabolite formation. The structures of these metabolites were determined with the use of elect
Nonclassical mucosal antibodies predominate in genital secretions of HIV-1 infected chimpanzees.: J Med Primatol. 1995 Feb;24(2):53-60. Unique Identifier : AIDSLINE MED/96187232; Israel ZR; Marx PA; Department of Pathology, New York University Medical Center, NY,; USA.; To identify mucosal immunity in HIV-infected chimpanzees, IgG, IgA, and IgM from plasma, saliva, rectal swabs, vaginal washes, semen, and urethral washes were tested from four male and three female HIV-1IIIB infected chimpanzees. The level of HIV infections in the seven chimpanzees were classified as high, intermediat
Tumor necrosis factor-alpha in serum of macaques during SIVmac251 acute infection.: J Med Primatol. 1995 Feb;24(2):94-100. Unique Identifier : AIDSLINE MED/96187238; Clayette P; Le Grand R; Noack O; Vaslin B; Le Naour R; Benveniste O; Theodoro F; Fretier P; Dormont D; Laboratoire de Neuropathologie experimentate et Neurovirologie,; CEA/DSV/DPTE/SSA Institut Paris-Sud sur les Cytokines, Fontenay; aux Roses, France.; TNF secretion was explored in sera during acute SIV-infection of cynomolgus macaques. A peak of TNF was detected in sera of animals in concomitance with SIV replication. Likewise, AZT treatment delayed and reduced peaks of viral replication and TNF pr
Effect of radon on the immune system: alterations in the cellularity and functions of T cells in lymphoid organs of mouse.: J Toxicol Environ Health. 1996 Apr 19;47(6):535-52. Unique Identifier : AIDSLINE MED/96201634; Nagarkatti M; Nagarkatti PS; Brooks A; Department of Biomedical Sciences and Pathobiology, College of; Veterinary Medicine, Virginia Polytechnic Institute and State; University, Blacksburg 24061, USA.; Exposure to radon and its progeny induces significant damage to the cells of the respiratory tract and causes lung cancer. Whether a similar exposure to radon would alter the functions of the immune system has not been previously investigated. In the current study, we investigated the effect of exposure of C57BL/6 mic
Toxic megacolon caused by cytomegalovirus colitis in a multiply injured patient.: J Trauma. 1996 Apr;40(4):644-6. Unique Identifier : AIDSLINE MED/96185971; Machens A; Bloechle C; Achilles EG; Bause HW; Izbicki JR; Department of General Surgery, University Hospital Eppendoft,; University of Hamburg, Germany.; Cytomegalovirus ( CMV ) colitis is a rare event that has been described mainly in immunocompromised patients with immunosuppressive medication or HIV infection. An association with severe trauma has not been described previously. We report a formerly healthy, mult
From the Centers for Disease Control and Prevention. HIV/AIDS education and prevention programs for adults in prisons and jails and juveniles in confinement facilities--United States, 1994.: JAMA. 1996 May 1;275(17):1306-8. Unique Identifier : AIDSLINE MED/96200901
Survival from early, intermediate, and late stages of HIV infection.: JAMA. 1996 May 1;275(17):1329-34. Unique Identifier : AIDSLINE MED/96200915; Enger C; Graham N; Peng Y; Chmiel JS; Kingsley LA; Detels R; Munoz A; Department of Oncology, Johns Hopkins School of Medicine,; Baltimore, Md, USA.; OBJECTIVE--To estimate expected survival time among homosexual men infected with the human immunodeficiency virus type 1 (HIV-1) by (1) the calendar period before (1985-1988) and after (1989-1993) the widespread availability of acquired immunodeficiency syndrome (AIDS) treatments with antiretroviral and prophylactic i
A meta-analytic evaluation of the polymerase chain reaction for the diagnosis of HIV infection in infants [see comments]: JAMA. 1996 May 1;275(17):1342-8. Unique Identifier : AIDSLINE MED/96200918; Owens DK; Holodniy M; McDonald TW; Scott J; Sonnad S; Section of General Internal Medicine, VA Palo Alto Health Care; System, CA 94304, USA.; OBJECTIVE--To evaluate the sensitivity and specificity of the polymerase chain reaction (PCR) for the diagnosis of infection with human immunodeficiency virus (HIV) in infants. DATA SOURCES--We used studies published between 1988 and 1994 identified in a literature search of 17 databases, including MEDLINE. STUDY SELE
DNA polymerase chain reaction for the diagnosis of vertical HIV infection [editorial; comment]: JAMA. 1996 May 1;275(17):1360-1. Unique Identifier : AIDSLINE MED/96200921; Luzuriaga K; Sullivan JL
Primary care of the HIV patient: standard practice and new developments in the era of managed care.: Med Clin North Am. 1996 Mar;80(2):375-410. Unique Identifier : AIDSLINE MED/96197390; Kocurek K; Division of General Internal Medicine, University of California; San Francisco, California, USA.; It is easy when taking care of the patient with AIDS to lose sight of the whole person and become focused on the details of micromanagement, distracted by the array of new therapies, and overwhelmed by the financial risks of the disease. It is therefore critical that a healing and respectful relationship is developed
Risk of transmission of human immunodeficiency virus infection during tympano-ossicular homograft: an experimental study.: Laryngoscope. 1996 Mar;106(3 Pt 1):334-7. Unique Identifier : AIDSLINE MED/96197642; Meylan PR; Duscher A; Mudry A; Monnier P; Institute of Microbiology, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.; It is generally agreed that middle ear reconstructive surgery performed with tympano-ossicular homografts produces superior functional results compared with prosthetic material, especially with respect to extrusion rate. The use of homografts, though, has been seriously hampered recently by the fear of transmission of
The role of p56lck in CD4-mediated suppression of CD3-induced early signaling events in T lymphocytes.: Life Sci. 1995 Mar 3;56(15):1287-97. Unique Identifier : AIDSLINE MED/96112110; Baier-Bitterlich G; Baier G; Gulbins E; Coggeshall KM; Altman A; Division of Cell Biology, La Jolla Institute for Allergy and; Immunology, CA 92037, USA.; Crosslinking of the CD4 coreceptor can inhibit subsequent T-cell activation via the T-cell antigen receptor (TCR)/CD3 complex. The ability of the human immunodeficiency virus (HIV) envelope protein, gp 120, to cause similar inhibition has implicated this inhibitory signal in the induction of T-cell anergy and apoptosi
The estrogen antagonist tamoxifen inhibits carrageenan induced inflammation in LEW/N female rats.: Life Sci. 1996;58(16):PL281-6. Unique Identifier : AIDSLINE MED/96216516; Misiewicz B; Griebler C; Gomez M; Raybourne R; Zelazowska E; Gold PW; Sternberg EM; Clinical Neuroendocrinology Branch, National Institute of Mental; Health, Bethesda, MD 20892, USA.; Carrageenan induces a measurable inflammatory response in susceptible animals, and mature females are more responsive to carrageenan, than males. In the present study, we tested whether the estrogen antagonist tamoxifen influences carrageenan-induced inflammatory responses. Female LEW/N rats were treated with tamoxife
Haemophilia--darkest hours before the dawn [editorial]: Med J Aust. 1996 Apr 15;164(8):453-5. Unique Identifier : AIDSLINE MED/96199839; Street AM; Ekert H
HIV and musculoskeletal disease.: Med J Aust. 1996 Apr 15;164(8):480-1. Unique Identifier : AIDSLINE MED/96199847; Bertouch JV; Department of Rheumatology, Prince of Wales and Prince Henry; Hospitals, Sydney, NSW.; Prompt and accurate diagnosis of musculoskeletal disease in HIV infection should result in effective therapy, although some of the usual treatments are contraindicated.
HIV-related cardiovascular disease.: Med J Aust. 1996 Apr 15;164(8):482. Unique Identifier : AIDSLINE MED/96199848; Feneley MP; Department of Cardiology, St Vincent's Hospital, Sydney, NSW.; Heart disease is common in HIV, but often asymptomatic. As improved therapies prolong the lives of HIV-infected patients, an increase in symptomatic heart disease can be expected.
HIV and renal disease.: Med J Aust. 1996 Apr 15;164(8):483. Unique Identifier : AIDSLINE MED/96199849; Frankum BS; Savdie E; Department of Medicine, Nepean Hospital, Sydney, NSW.; Renal parenchymal and fluid and electrolyte abnormalities may complicate hospitalisation in 20% of patients. HIV-specific renal abnormalities are being defined, but most follow opportunistic infection or drug nephrotoxicity. Principles of treatment are largely the same as for patients without HIV.
HIV and eye disease.: Med J Aust. 1996 Apr 15;164(8):484-6. Unique Identifier : AIDSLINE MED/96199850; McCluskey PJ; Hall AJ; Lightman S; Department of Ophthalmology, St Vincent's Hospital, Sydney, NSW.; Blindness is a threatening complication of HIV infection, but one that can be prevented by correct diagnosis and management of ocular disease. The general practitioner can play a vital role in diagnosis by being familiar with the types of ocular disease seen at different stages of HIV infection.
HIV and haematological disease.: Med J Aust. 1996 Apr 15;164(8):487-8. Unique Identifier : AIDSLINE MED/96199851; Street AM; Gibson J; Haematology Unit, Alfred Healthcare Group of Hospitals,; Melbourne, Vic.; Patients with HIV infection may present with symptoms and/or signs of anaemia, neutropenia or thrombocytopenia at all stages, including seroconversion.
HIV-related lymphoma and other malignancies.: Med J Aust. 1996 Apr 15;164(8):489-91. Unique Identifier : AIDSLINE MED/96199852; Milliken ST; Clezy KR; Cooper SG; Romeril KR; St Vincent's Hospital, Sydney, NSW.; Treating systemic malignancies requires specialist skill and experience, with active treatment often providing the best initial palliation of symptoms. A full management plan involving general practitioner, patient and others is essential at this stage of HIV disease.
Secondary malignancies in a child with Hodgkin's disease: T-cell lymphoma and myelodysplastic syndrome evolving into acute nonlymphoblastic leukaemia.: Med Pediatr Oncol. 1996 May;26(5):359-66. Unique Identifier : AIDSLINE MED/96203990; Polychronopoulou S; Panagiotou JP; Papadakis T; Mavrou A; Anagnostou D; Haidas S; Department of Paediatric Haematology/Oncology Aghia Sophia; Children's Hospital, Athens, Greece.; Hodgkin s disease (HD) has been linked to an increase risk of second malignant neoplasms (SMN), especially non-Hodgkin s lymphoma (NHL) and acute nonlymphoblastic leukaemia (ANLL). The mutagenic property of cytotoxic therapy as well as defective immunity have been implicated as pla
AIDS advisers disagree over events in HIV blood scandal [news]: Nature. 1996 Apr 25;380(6576):660. Unique Identifier : AIDSLINE MED/96202714; Swinbanks D
Controversial AIDS vaccine fails to delay disease [news]: Nature. 1996 Apr 25;380(6576):662. Unique Identifier : AIDSLINE MED/96202716
T-cell infiltration of primary CNS lymphoma.: Neurology. 1996 Feb;46(2):440-4. Unique Identifier : AIDSLINE MED/96181971; Bashir R; Chamberlain M; Ruby E; Hochberg FH; Department of Internal Medicine, University of Nebraska Medical; Center, Omaha,NE 68198-2045, USA.; We stained 13 primary CNS lymphomas (PCNSLs) (six from patients with AIDS, seven from immunocompetent patients) with a panel of antibodies to T cells (pan T cell [CD3], T helper cell [CD4], T suppressor cell [CD8], delta/delta cell [CD4-8-]), B cells (CD20), hematopoietic cells (T200), and NK cell (CD56). We estimated
Prognosis and response to therapy of cytomegalovirus encephalitis and meningomyelitis in AIDS.: Neurology. 1996 Feb;46(2):444-50. Unique Identifier : AIDSLINE MED/96181972; Cohen BA; Department of Neurology, Northwestern University Medical School,; Chicago, IL 60611, USA.; Effective diagnosis and treatment of cytomegalovirus infection of the nervous system in AIDS patients has been limited by a lack of sensitive diagnostic measures. Retrospective series suggest a poor prognosis for cytomegalovirus encephalitis with rapid mortality. Polymerase chain r
Ocular motor dysfunction in HIV-1-infected subjects: a quantitative oculographic analysis.: Neurology. 1996 Feb;46(2):451-7. Unique Identifier : AIDSLINE MED/96181973; Johnston JL; Miller JD; Nath A; Department of Medicine, University of Manitoba, Winnipeg, Canada.; We recorded eye and head movements in 13 human immunodeficiency virus type-1 (HIV-1)-infected patients with CD4 counts of less than or equal to 500 cells/mm3 using magnetic search coil oculography. Horizontal and vertical saccades, smooth pursuit, and vestibular smooth eye movements were recorded, as were horizontal a
Subacute measles virus encephalitis: a new and fatal opportunistic infection in a patient with AIDS.: Neurology. 1996 Feb;46(2):586-7. Unique Identifier : AIDSLINE MED/96182008; Budka H; Urbanits S; Liberski PP; Eichinger S; Popow-Kraupp T; Institute of Neurology, University of Vienna, Wien, Austria.
HIV nephropathy in children.: Pediatr Clin North Am. 1995 Dec;42(6):1469-85. Unique Identifier : AIDSLINE MED/96110883; Zilleruelo G; Strauss J; Department of Pediatrics, University of Miami School of Medicine,; Florida, USA.; The evaluation and management of children with HIV nephropathy provide a great challenge to the pediatric nephrologist caring for patients with this tragic illness, of which the nephropathy is only part of their problem and extends beyond the patient to the family and all of the supportive team involved. Care decision
Gastrointestinal and nutritional problems in children with immunodeficiency and AIDS.: Pediatr Clin North Am. 1996 Apr;43(2):573-90. Unique Identifier : AIDSLINE MED/96198019; Winter H; Chang TI; Boston City Hospital, Boston, Massachusetts, USA.; Immunodeficient children pose a challenge to clinicians because of the interrelationship between infectious disease, metabolism, gastrointestinal tract function, psychosocial problems, and immune function. The interplay between these factors is not always clear, and frequently the best course of therapy is obscured be
Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.: Nucleic Acids Res. 1996 Apr 1;24(7):1308-13. Unique Identifier : AIDSLINE MED/96188866; Lutz MJ; Held HA; Hottiger M; Hubscher U; Benner SA; Department of Chemistry, Swiss Federal Institute of Technology,; Zurich, Switzerland.; Mammalian DNA polymerases alpha and epsilon, the Klenow fragment of Escherichia coli DNA polymerase I and HIV-1 reverse transcriptase (RT) were examined for their ability to incorporate components of an expanded genetic alphabet in different forms. Experiments were performed with templates containing 2 -deoxyxanthosin
[Respiratory system changes in persons infected with the HIV virus]: Pneumonol Pol. 1990 Sep-Oct;58(9-10):549-58. Unique Identifier : AIDSLINE MED/96204114; Niemirowska H; Przychodni Przyklinicznej Instytutu Gruzlicy i Chorob Pluc.
Statistical analysis of zidovudine (AZT) effect on CD4 cell counts in HIV disease.: Stat Med. 1996 Jan 15;15(1):75-92. Unique Identifier : AIDSLINE MED/96201062; Mcneil AJ; Gore SM; Institute of Applied Mathematics, University of Zurich.; We fit a class of random effects linear growth curve models for the square root of CD4 count to serial marker data from 164 HIV-positive individuals with known (or accurately estimated) dates of seroconversion and at least 10 CD4 measurements each (median 16). We do so by adopting a Bayesian viewpoint and using the Ma
Characterization of HIV incubation distributions and some comparative studies.: Stat Med. 1996 Jan 30;15(2):197-220. Unique Identifier : AIDSLINE MED/96201077; Tan WY; Lee SR; Tang SC; Department of Mathematical Sciences, University of Memphis, TN; 38152, USA.; In this paper we use a general stochastic model to characterize the HIV incubation distributions. We generate some Monte Carlo data under different conditions and compare the fitting of HIV incubation distributions by some well known parametric models and some non-parametric methods. The parametric models include most
The shape of the distribution of the number of sexual partners.: Stat Med. 1996 Jan 30;15(2):221-30. Unique Identifier : AIDSLINE MED/96201078; Kault D; Anton Breinl Centre for Tropical and Medicine, James Cook; University, Townsville, Qld, Australia.; Information on the number of sexual partners that people have is necessary for predicting the likely long term course of the AIDS epidemic. More information is required than is provided by simply stating the mean and variance of the number of partners. It is useful to find a family of curves which approximate data on
Pulmonary sarcoidosis coexisting with systemic lupus erythematosus.: Scand J Rheumatol. 1996;25(2):109-11. Unique Identifier : AIDSLINE MED/96216528; Schnabel A; Barth J; Schubert F; Gross WL; Rheumatologische Poliklinik, Medizinische Universitat Lubeck,; Germany.; A 23 year old female presented with fatigue, Raynaud s syndrome, symmetric polyarthritis, lymphocytop