Peripheral blood lymphocyte subsets in patients with stomach cancer. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Peripheral blood lymphocyte subsets in patients with stomach cancer.

J Korean Med Sci. 1995 Jun;10(3):164-8. Unique Identifier : AIDSLINE MED/96089674
Hong WS; Min YI; Son YS; Hong SI; Department of Internal Medicine, Asan Medical Center, University; of Ulsan, Seoul, Korea.

Abstract: The present study was conducted in order to investigate the immunologic alterations alongside the numerical changes in peripheral blood lymphocytes(PBL) and their subsets in stomach cancer patients. Lymphocyte surface markers were determined in 85 stomach cancer patients and 49 controls by indirect immunofluorescence technique using monoclonal antibodies. Monoclonal antibodies used were Leu 2a(CD8, suppressor/cytotoxic T cells), Leu 3a(CD4, inducer/helper T cells), Leu 4(CD3, pan T reagent), Leu 11(CD16, natural killer cells) and Leu 12(CD19, B cells). The numbers of PBL, CD3+, CD4+, CD8+, CD16+ and CD19+ cells significantly decreased and the CD4: CD8 value increased in 85 patients with stomach cancer compared to those in controls(p < 0.01). In stage I(n = 17), neither PBL, their subsets nor the CD4: CD8 value were significantly different from those of the controls. In stage II(n = 17), the numbers of PBL, CD3+, CD4+ and CD8+ cells decreased(p < 0.01). In stage III(n = 24) and IV(n = 27), PBL and all subsets measured decreased(p < 0.01). The CD4: CD8 value showed significant increases in stages III and IV(p < 0.01), because the CD8+ cells decreased to a greater extent than did the CD4+ cells. The results demonstrating that the lymphocyte subsets are depressed differentially with the stage suggest that host immunity is impaired with the progression of stomach cancer.
Keywords: Adult Age Distribution Aged Antigens, CD19/ANALYSIS Antigens, CD3/ANALYSIS CD4-Positive T-Lymphocytes/CYTOLOGY CD8-Positive T-Lymphocytes/CYTOLOGY Female Human Lymphocyte Count Lymphocyte Subsets/CHEMISTRY/*IMMUNOLOGY Male Middle Age Receptors, IgG/ANALYSIS Sex Distribution Stomach Neoplasms/BLOOD/*IMMUNOLOGY JOURNAL ARTICLEKWDadultagedistributionagedantigens,cd19/analysisantigens,cd3/analysiscd4-positivet-lymphocytes/cytologycd8-positivet-lymphocytes/cytologyfemalehumanlymphocytecountlymphocytesubsets/chemistry/KWDimmunologymalemiddleagereceptors,igg/analysissexdistributionstomachneoplasms/blood/KWDimmunologyjournalarticle
960430
M9640876

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .