Comparative assessment of small intestinal and colonic permeability in HIV-infected homosexual men. NLM AIDSLINE Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Comparative assessment of small intestinal and colonic permeability in HIV-infected homosexual men.

AIDS. 1995 Sep;9(9):1009-16. Unique Identifier : AIDSLINE MED/96085715
Obinna FC; Cook G; Beale T; Dave S; Cunningham D; Fleming SC; Claydon E; Harris JW; Kapembwa MS; Booth Research Laboratory, St Mary's Hospital Medical School,; Harrow, UK.

Abstract: OBJECTIVES: To investigate both small and large intestinal permeability in HIV-positive subjects, and correlate variation in intestinal mucosal abnormality with immunological and nutritional markers of HIV disease. METHODS: Small and large intestinal permeability studies were performed in 14 HIV-seropositive patients and eight healthy men. Eight out of the 14 patients had diarrhoea and all subjects were negative for enteropathogens. Small intestinal permeability was determined using the lactulose-mannitol test and large intestinal permeability using the colonic absorption of 51Cr-EDTA. In addition, CD4 cell count, beta 2-microglobulin, C-reactive protein estimation and anthropometry were carried out in all subjects. RESULTS: HIV-seropositive subjects had higher lactulose-mannitol ratios (LMR; 0.084 +/- 0.007 versus 0.013 +/- 0.0008) and lower 51Cr activity (1.986 +/- 0.066 versus 3.115 +/- 0.560) than controls (P < 0.0004 and P < 0.05, respectively). Colonic uptake of 51Cr-EDTA was no different between subjects with and those without diarrhoea (2.04 +/- 0.124 versus 1.92 +/- 0.143, P > 0.05). A negative correlation was found between LMR and 51Cr-EDTA, but only for patients with diarrhoea (r = -0.81; P = 0.015). CONCLUSION: Regional variation affecting intestinal absorptive function occurs in patients with HIV-related diarrhoea and is characterized by increased LMR and reduced colonic uptake of 51Cr-EDTA. The pathogenesis and clinical significance of such changes are unknown.
Keywords: Adult AIDS-Related Opportunistic Infections/DIAGNOSIS/PHYSIOPATHOLOGY Colon/PHYSIOPATHOLOGY CD4 Lymphocyte Count Diarrhea/PHYSIOPATHOLOGY Homosexuality, Male Human HIV Infections/DIAGNOSIS/*PHYSIOPATHOLOGY HIV Seropositivity/DIAGNOSIS/PHYSIOPATHOLOGY Intestinal Absorption/*PHYSIOLOGY Intestinal Mucosa/*PHYSIOPATHOLOGY Intestine, Small/PHYSIOPATHOLOGY Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadultaids-relatedopportunisticinfections/diagnosis/physiopathologycolon/physiopathologycd4lymphocytecountdiarrhea/physiopathologyhomosexuality,malehumanhivinfections/diagnosis/KWDphysiopathologyhivseropositivity/diagnosis/physiopathologyintestinalabsorption/KWDphysiologyintestinalmucosa/KWDphysiopathologyintestine,small/physiopathologymalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
960430
M9640873

Copyright © 1996 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .