Micronutrients and HIV-1 disease progression.

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Micronutrients and HIV-1 disease progression.

AIDS. 1995 Sep;9(9):1051-6. Unique Identifier : AIDSLINE MED/96085720
Baum MK; Shor-Posner G; Lu Y; Rosner B; Sauberlich HE; Fletcher MA; Szapocznik J; Eisdorfer C; Buring JE; Hennekens CH; Department of Epidemiology and Public Health, University of Miami; School of Medicine, Florida 33101, USA.

Abstract: OBJECTIVE: To determine whether nutritional status affects immunological markers of HIV-1 disease progression. DESIGN: A longitudinal study, to evaluate the relationship between plasma levels of nutrients and CD4 cell counts, along and in combination with beta 2-microglobulin (beta 2M; AIDS index) over an 18-month follow-up. METHODS: Biochemical measurements of nutritional status including plasma proteins, zinc, iron and vitamins B1, B2, B6, B12 (cobalamin), A, E, C and folate and immunological markers [lymphocyte subpopulations (CD4) and beta 2M] were obtained in 108 HIV-1-seropositive homosexual men at baseline and over three 6-month time periods. Changes in nutrient status (e.g., normal to deficient, deficient to normal), were compared with immunological parameters in the same time periods using an autoregressive model. RESULTS: Development of deficiency of vitamin A or vitamin B12 was associated with a decline in CD4 cell count (P = 0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B12 and zinc was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and 0.0112, respectively). These findings were largely unaffected by zidovudine use. For vitamin B12, low baseline status significantly predicted accelerated HIV-1 disease progression determined by CD4 cell count (P = 0.041) and the AIDS index (P = 0.005). CONCLUSIONS: These data suggest that micronutrient deficiencies are associated with HIV-1 disease progression and raise the possibility that normalization might increase symptom-free survival.

Keywords: beta 2-Microglobulin/METABOLISM Adult Blood Proteins/METABOLISM *CD4 Lymphocyte Count Disease Progression Follow-Up Studies Human HIV Infections/*IMMUNOLOGY HIV-1/*IMMUNOLOGY Longitudinal Studies Male Middle Age *Nutritional Status Support, U.S. Gov't, P.H.S. Trace Elements/*BLOOD Vitamin A Deficiency/IMMUNOLOGY Vitamin B 12 Deficiency/IMMUNOLOGY Vitamins/*BLOOD Zinc/BLOOD/DEFICIENCY JOURNAL ARTICLE
960430
M9640868

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