1996

[Il:libro italiano dell'AIDS.] 1. ed.: Milano ; New York : McGraw-Hill libri Italia, c1994 vi, 345 p. : ill Unique Identifier : AIDSLINE CAT/9512614; Dianzani F
[AIDS : nuova frontiera : declino della metafora e del dogma : fatti e idee per una strategia terapeutica innovativa.]: Roma : Lombardo editore, c1995 xvi, 208 p. : ill Unique Identifier : AIDSLINE CAT/9516087; Passi S
[Em tempos de AIDS : sexo seguro, prevencao, drogas, adolescentes, mulheres, apoio psicologico, aos portadores : viva a vida.]: Sao Paulo : Summus, c1992 214 p. : ill Unique Identifier : AIDSLINE CAT/9414831; Paiva V
[Hemofilia, VIH y SIDA : alternativas en tu vida.] 1. ed.: Vitoria-Gasteiz : Servicio Central de Publicaciones del Gobierno Vasco, 1991 84 p. : ill (Documentos de bienestar social ; 42) Unique Identifier : AIDSLINE CAT/9409133; Cooper J
[HIV-Pravention in der Schweiz : Ziele, Strategien, Massnahmen.] 1. Aufl.: Liebefeld : Bundesamt fur Gesundheitswesen, Abt. Gesundheitsforderung, Sektion Aids, 1993 xiv, 290 p. : ill Unique Identifier : AIDSLINE CAT/9516447
Report of the Technical Advisory Meeting of Implications of the Newly Identified HIV-1 Subtype O Viruses for HIV Diagnosis : Geneva, 9-10 June 1994.: Identified HIV-1 Subtype O Viruses for HIV Diagnosis Geneva : World Health Organization, [1995?] 23 p. : ill Unique Identifier : AIDSLINE CAT/9600581
[Systeme de classement de la documentation des infections a HIV-SIDA.]: Bruxelles : UCL-RESO, Centre de documentation, [1989] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9407693; Bertrand-Baschwitz MA
[SIDA : crisis o reto transformador?.] 2. ed.: Rio Piedras, P.R. : Editorial Cultural, 1990 198 p. : ill., ports Unique Identifier : AIDSLINE CAT/9409235; Mock-Montes G
[SIDA, les secrets d'une polemique : recherche, interets financiers et medias.] 1. ed.: Paris : Presses universitaires de France, c1993 viii, 279 p (Science, histoire et societe) Unique Identifier : AIDSLINE CAT/9434845; Seytre B
The:AIDS mirage.: Sydney, NSW : University of New South Wales Press, 1994 62 p. : port (Frontlines ; 4) Unique Identifier : AIDSLINE CAT/9517546; Caton H
[AIDS : igyto imunodeficito sindromas.]: Vilnius : Mokslas, 1991 127 p. : ill (Gydytojui praktikui) Unique Identifier : AIDSLINE CAT/9403585; Devaitene I
Legal and ethical aspects of HIV-related research.: New York : Plenum Press, c1995 xiv, 218 p. : ill (Language of science) Unique Identifier : AIDSLINE CAT/9516469; Loue S
Social research on HIV/AIDS in New Zealand : a bibliography, 1984-1993.: Auckland : Health Research Council of New Zealand, 1994 73 p Unique Identifier : AIDSLINE CAT/9517084; Glaisyer N; Chetwynd J; Plumridge E
Strong shadows : scenes from an inner city AIDS clinic.: [New York, N.Y. : W.H. Freeman], c1995 xvi, 243 p Unique Identifier : AIDSLINE CAT/9516467; Zuger A
Thalidomide: rationale for renewed use in immunological disorders.: Drug Saf. 1995 Jun;12(6):364-9. Unique Identifier : AIDSLINE MED/96134441; Schuler U; Ehninger G; Technische Universitat Dresden, Germany.; Despite its inherent teratogenic risk, thalidomide has over the years proven to be of clinical use in a small number of mainly immunological diseases (e.g. erythema nodosum leprosum, Behcet s syndrome and rheumatoid arthritis). The mode of action of thalidomide is still poorly understood. Recent research has shown a d
Peripheral blood lymphocyte subsets in patients with stomach cancer.: J Korean Med Sci. 1995 Jun;10(3):164-8. Unique Identifier : AIDSLINE MED/96089674; Hong WS; Min YI; Son YS; Hong SI; Department of Internal Medicine, Asan Medical Center, University; of Ulsan, Seoul, Korea.; The present study was conducted in order to investigate the immunologic alterations alongside the numerical changes in peripheral blood lymphocytes(PBL) and their subsets in stomach cancer patients. Lymphocyte surface markers were determined in 85 stomach cancer patients and 49 controls by indirect immunofluorescence
The sensitivity of HIV-1 DNA polymerase chain reaction in the neonatal period and the relative contributions of intra-uterine and intra-partum transmission.: AIDS. 1995 Sep;9(9):F7-11. Unique Identifier : AIDSLINE MED/96085711; Dunn DT; Brandt CD; Krivine A; Cassol SA; Roques P; Borkowsky W; De Rossi A; Denamur E; Ehrnst A; Loveday C; et al; Department of Epidemiology and Biostatics, Institute of Child; Health, London, UK.; OBJECTIVE: To derive reliable estimates of the sensitivity of HIV-1 DNA polymerase chain reaction (PCR) in the neonatal period and to quantify the relative contributions of intra-uterine and intra-partum transmission. METHODS: After reviewing studies on the early diagnosis of HIV-1 infection, investigators were asked
Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia.: AIDS. 1995 Sep;9(9):1001-8. Unique Identifier : AIDSLINE MED/96085714; Ranki A; Nyberg M; Ovod V; Haltia M; Elovaara I; Raininko R; Haapasalo H; Krohn K; Department of Dermatology and Venereal Diseases, University of; Helsinki, Finland.; OBJECTIVE: To relate the expression of HIV regulatory proteins and HIV-specific mRNA in the brain cells of infected individuals with clinical neurological disease. DESIGN: Formalin-fixed postmortem brain tissue from 14 HIV-infected adult patients, with previous repeated neurological and neuroradiological examinations,
Comparative assessment of small intestinal and colonic permeability in HIV-infected homosexual men.: AIDS. 1995 Sep;9(9):1009-16. Unique Identifier : AIDSLINE MED/96085715; Obinna FC; Cook G; Beale T; Dave S; Cunningham D; Fleming SC; Claydon E; Harris JW; Kapembwa MS; Booth Research Laboratory, St Mary's Hospital Medical School,; Harrow, UK.; OBJECTIVES: To investigate both small and large intestinal permeability in HIV-positive subjects, and correlate variation in intestinal mucosal abnormality with immunological and nutritional markers of HIV disease. METHODS: Small and large intestinal permeability studies were performed in 14 HIV-seropositive patients
Generation of diversity in the hierarchy of T-cell epitope responses following different routes of immunization with simian immunodeficiency virus protein.: AIDS. 1995 Sep;9(9):1017-24. Unique Identifier : AIDSLINE MED/96085716; Brookes R; Bergmeier LA; Mitchell E; Walker J; Tao L; Klavinskis L; Meyers NJ; Layton G; Adams SE; Lehner T; Department of Immunology, United Medical School, Guy's & St; Thomas' Hospital, London, UK.; OBJECTIVES: To examine whether the route of immunization determines the hierarchy of T-cell epitope proliferative responses in macaques. DESIGN: Macaques were immunized with a recombinant simian immunodeficiency virus (SIV) p27 core protein by the intramuscular, male and female genital or rectal route, each of which w
Zidovudine plus interferon-alpha versus zidovudine alone in HIV-infected symptomatic or asymptomatic persons with CD4+ cell counts > 150 x 10(6)/L: results of the Zidon trial. Zidon Study Group.: AIDS. 1995 Sep;9(9):1025-35. Unique Identifier : AIDSLINE MED/96085717; Fernandez-Cruz E; Lang JM; Frissen J; Furner V; Chateauvert M; Boucher CA; Dowd P; Stevens J; Department of Immunology, General Hospital Gregorio Maranon,; Madrid, Spain.; OBJECTIVE: To evaluate the efficacy and safety of zidovudine (ZDV) and lymphoblastoid interferon (IFN)-alpha combination therapy compared with ZDV monotherapy in HIV-infected subjects with CD4+ cell counts between 150 and 500 x 10(6)/l. DESIGN: Open, randomized control
Steroids do not enhance the risk of developing tuberculosis or other AIDS-related diseases in HIV-infected patients treated for Pneumocystis carinii pneumonia.: AIDS. 1995 Sep;9(9):1037-41. Unique Identifier : AIDSLINE MED/96085718; Martos A; Podzamczer D; Martinez-Lacasa J; Rufi G; Santin M; Gudiol F; Infectious Disease Service, Ciutat Sanitaria de Bellvitge,; University of Barcelona, Spain.; OBJECTIVE: To evaluate the risk of developing tuberculosis or other AIDS-related diseases (ARD) in HIV-infected patients treated with corticosteroids as adjunctive therapy for Pneumocystis carinii pneumonia (PCP). DESIGN: Retrospective study. SETTING: Infectious Disease Service of a 1000-bed university teaching hospit
Early central nervous system response to HIV infection: sleep distortion and cognitive-motor decrements.: AIDS. 1995 Sep;9(9):1043-50. Unique Identifier : AIDSLINE MED/96085719; White JL; Darko DF; Brown SJ; Miller JC; Hayduk R; Kelly T; Mitler MM; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California, USA.; OBJECTIVE: To repeat and extend findings suggesting that sleep disturbance, excessive daytime sleepiness, and degraded cognitive-motor abilities may be early markers of central nervous system (CNS) involvement in HIV infection. DESIGN: A controlled, cross-sectional, prospective analysis. SETTING: Clinical research cen
Micronutrients and HIV-1 disease progression.: AIDS. 1995 Sep;9(9):1051-6. Unique Identifier : AIDSLINE MED/96085720; Baum MK; Shor-Posner G; Lu Y; Rosner B; Sauberlich HE; Fletcher MA; Szapocznik J; Eisdorfer C; Buring JE; Hennekens CH; Department of Epidemiology and Public Health, University of Miami; School of Medicine, Florida 33101, USA.; OBJECTIVE: To determine whether nutritional status affects immunological markers of HIV-1 disease progression. DESIGN: A longitudinal study, to evaluate the relationship between plasma levels of nutrients and CD4 cell counts, along and in combination with beta 2-microglobulin (beta 2M; AIDS index) over an 18-month fol
HIV-1 and immunological changes during pregnancy: a comparison between HIV-1-seropositive and HIV-1-seronegative women in Nairobi, Kenya.: AIDS. 1995 Sep;9(9):1057-60. Unique Identifier : AIDSLINE MED/96085721; Temmerman M; Nagelkerke N; Bwayo J; Chomba EN; Ndinya-Achola J; Piot P; Department of Obstetrics and Gynaecology, University of Ghent,; Belgium.; OBJECTIVE: To assess changes in the proportion of CD4 and CD8 T-lymphocyte profiles during pregnancy, at delivery and postpartum, and to determine whether HIV-1 infection affects the normal profile. DESIGN AND METHODS: A total of 416 pregnant HIV-1-infected women and an age and parity-matched HIV-seronegative group of
Declining prevalence of HIV-1 infection in young Thai men.: AIDS. 1995 Sep;9(9):1061-5. Unique Identifier : AIDSLINE MED/96085722; Mason CJ; Markowitz LE; Kitsiripornchai S; Jugsudee A; Sirisopana N; Torugsa K; Carr JK; Michael RA; Nitayaphan S; McNeil JG; Armed Forces Research Institute of Medical Sciences, Bangkok,; Thailand.; OBJECTIVE: To evaluate trends in HIV-1 seroprevalence in Thailand . DESIGN: HIV-1 serosurvey of successive cohorts of young Thai men entering service with the Royal Thai Army (RTA) between November 1989 and November 1994. METHODS: In November 1989, the RTA Medical Department began
Declining risk for HIV among injecting drug users in Kathmandu, Nepal: the impact of a harm-reduction programme.: AIDS. 1995 Sep;9(9):1067-70. Unique Identifier : AIDSLINE MED/96085723; Peak A; Rana S; Maharjan SH; Jolley D; Crofts N; Lifesaving and Lifegiving Society, Kathmandu, Nepal.; OBJECTIVE: To measure changes in self-reported risk behaviour for HIV infections and HIV seroprevalence among injecting drug user (IDU) clients of an outreach harm-reduction programme in Kathmandu, Nepal . METHODS: The Lifesaving and
HIV, sexually transmitted diseases and gynaecologic disorders in women: increased risk for genital herpes and warts among HIV-infected prostitutes in Amsterdam.: AIDS. 1995 Sep;9(9):1071-8. Unique Identifier : AIDSLINE MED/96085724; Fennema JS; van Ameijden EJ; Coutinho RA; van den Hoek AA; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.; OBJECTIVES: To determine the incidence of sexually transmitted diseases (STD; gonorrhoea, early syphilis, Chlamydia trachomatis infection, trichomoniasis and primary genital herpes ) and gynaecologic disorders (vaginal candidiasis, anaerobic vaginosis, genital ulcerations of unkn
Willingness to participate in AIDS vaccine trials among high-risk populations in northern Thailand.: AIDS. 1995 Sep;9(9):1079-83. Unique Identifier : AIDSLINE MED/96085725; Celentano DD; Beyrer C; Natpratan C; Eiumtrakul S; Sussman L; Renzullo PO; Khamboonruang C; Nelson KE; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, Maryland 21205, USA.; OBJECTIVES: To determine the anticipated participation in a prophylactic AIDS vaccine trial and to identify perceived benefits and barriers to enrollment of HIV-seronegative volunteers at risk of HIV infection in northern Thailand . DESIGN: A cross-sectional survey. METHODS: Subje
Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men.: AIDS. 1995 Sep;9(9):1085-92. Unique Identifier : AIDSLINE MED/96085726; Spijkerman IJ; Koot M; Prins M; Keet IP; van den Hoek AJ; Miedema F; Coutinho RA; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.; OBJECTIVE: To study the prevalence, incidence and predictive value for progression to AIDS of the HIV-1 syncytium-inducing (SI) phenotype in HIV-infected injecting drug users (IDU) compared with HIV-infected homosexual men. DESIGN: Two prospective cohort studies on HIV-1 infection among IDU and homosexual men. METHODS
Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand.: AIDS. 1995 Sep;9(9):1093-7. Unique Identifier : AIDSLINE MED/96085727; Cohen CR; Duerr A; Pruithithada N; Rugpao S; Hillier S; Garcia P; Nelson K; Department of Obstetrics and Gynecology, Northwestern University,; Chicago, Illinois, USA.; OBJECTIVE: To investigate the relationship between HIV seropositivity and bacterial vaginosis (BV) in a population at high risk for sexual acquisition of HIV. DESIGN: A cross-sectional study was conducted among 144 female commercial sex workers in Chiang Mai, Thailand . METHODS: T
Increased cerebrospinal fluid levels of soluble receptors for tumour necrosis factor in HIV-infected patients with neurological diseases [letter]: AIDS. 1995 Sep;9(9):1099-100. Unique Identifier : AIDSLINE MED/96085728; Vullo V; Mastroianni CM; Lichtner M; Mengoni F; Delia S
Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in AIDS dementia complex [letter]: AIDS. 1995 Sep;9(9):1100-1. Unique Identifier : AIDSLINE MED/96085729; Candito M; Durant J; Gurle V; Chambon P; Dellamonica P
Diffuse infiltrative CD8 lymphocytosis syndrome with predominant neurologic manifestations in two HIV-infected patients responding to zidovudine [letter]: AIDS. 1995 Sep;9(9):1101-2. Unique Identifier : AIDSLINE MED/96085730; Bachmeyer C; Dhote R; Blanche P; Tulliez M; Sicard D; Christoforov B
Detection of HIV-1 in surgical specimens from vitreous of AIDS patients [letter]: AIDS. 1995 Sep;9(9):1103-4. Unique Identifier : AIDSLINE MED/96085731; Flynn TE; Reppucci VS; McKinley G; Potash MJ; Volsky DJ
HIV saliva test for surveillance and surveys [letter]: AIDS. 1995 Sep;9(9):1104-5. Unique Identifier : AIDSLINE MED/96085732; Wongba C; Pagcharoenpol P; Eskes N; Frerichs RR; Silarug N
Syringe cleaning techniques and transmission of HIV [letter]: AIDS. 1995 Sep;9(9):1105-7. Unique Identifier : AIDSLINE MED/96085733; Druce JD; Locarnini SA; Birch CJ
Effects of megestrol acetate therapy on body composition and circulating testosterone concentrations in patients with AIDS [letter]: AIDS. 1995 Sep;9(9):1107-8. Unique Identifier : AIDSLINE MED/96085734; Engelson ES; Pi-Sunyer FX; Kotler DP
The importance of patients' own view about their quality of life [letter]: AIDS. 1995 Sep;9(9):1108-10. Unique Identifier : AIDSLINE MED/96085735; Leplege A; Rude N
Changing prevalence of hepatitis B virus and hepatitis D virus infection among injecting drug users in Hong Kong indicating a change in high-risk behaviour [letter]: AIDS. 1995 Sep;9(9):1110-2. Unique Identifier : AIDSLINE MED/96085736; Lim WL; Lo JY; Lee SH
Genetic therapies for HIV infections: promise for the future [editorial]: AIDS. 1995 Sep;9(9):985-93. Unique Identifier : AIDSLINE MED/96085712; Pomerantz RJ; Trono D
Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding.: AIDS. 1995 Sep;9(9):995-1000. Unique Identifier : AIDSLINE MED/96085713; Bonifaci N; Sitia R; Rubartelli A; Laboratory of Clinical Pathology, National Institute of Cancer; Research, Genoa, Italy.; OBJECTIVE: To characterize the transcellular transport of HIV-1 Tat. HIV-1 Tat contains a putative localization signal and no leader peptide; however, it can be released from virus-infected cells and taken up by uninfected cells. DESIGN AND METHODS: We constructed a chimeric protein between Tat and dihydrofolate reduc
[Controversial developments in AIDS[news]]: Boll Chim Farm. 1995 Oct;134(9):534. Unique Identifier : AIDSLINE MED/96058843; Vecchia C
Sensitive procedure for the amplification of HIV-1 RNA using a combined reverse-transcription and amplification reaction.: Biotechniques. 1995 Aug;19(2):178-80, 182. Unique Identifier : AIDSLINE MED/96134510; Nijhuis M; Boucher CA; Schuurman R; University of Amsterdam, Academic Medical Center, The; Netherlands.
Acute lung disease in the immunocompromised host: differential diagnosis at high-resolution CT.: Semin Ultrasound CT MR. 1995 Oct;16(5):353-60. Unique Identifier : AIDSLINE MED/96118023; Worthy S; Kang EY; Muller NL; Department of Radiology, University of British Columbia,; Vancouver, Canada.; The aim of this manuscript is to review the CT findings of pulmonary complications seen in acquired immunodeficiency syndrome (AIDS) and in non-AIDS immunocompromised patients. The most common pulmonary complications in patients with AIDS include infection, Kaposi s sarcoma, and AIDS-related lymphoma. The most common
Bronchiectasis: CT/clinical correlations.: Semin Ultrasound CT MR. 1995 Oct;16(5):395-419. Unique Identifier : AIDSLINE MED/96118027; McGuinness G; Naidich DP; Department of Radiology, New York University Medical Center, New; York 10016, USA.; The association between bronchiectasis and human immunodeficiency virus infection, the resurgence of tuberculosis, especially in urban and immunocompromised patients, and the recognition of bronchiectasis as a manifestation of rejection in the transplant population are emerging clinical settings in which establishing
Looking after health: the Basque health care reform.: J Public Health Med. 1995 Sep;17(3):254-9. Unique Identifier : AIDSLINE MED/96116355; Ortega-Benito JM; Department of Public Health, Lincolnshire Health Authorities,; Cross O'Cliff.
Erythropoietin.: Annu Rev Nutr. 1995;15:353-77. Unique Identifier : AIDSLINE MED/96138948; Fried W; Section of Hematology, Rush-Presbyterian-St. Luke's Medical; Center, Chicago, Illinois 60612, USA.; Erythropoietin (Epo), the first growth factor to be discovered, is an endocrine hormone produced by specialized renal cells. The rate of Epo production is determined primarily by the oxygen demands of these renal cells relative to their oxygen supply. However, Epo production is modulated by various hormones, nutrition
Quality of life and the spectrum of HIV infection.: Annu Rev Nurs Res. 1995;13:3-29. Unique Identifier : AIDSLINE MED/96113260; Holzemer WL; Wilson HS; School of Nursing, University of California, San Francisco, USA.
Science, medicine and clinical pharmacology. The Lilly Lecture 1994.: Br J Clin Pharmacol. 1995 Jul;40(1):1-9. Unique Identifier : AIDSLINE MED/96136583; Breckenridge A; Department of Pharmacology and Therapeutics, University of; Liverpool, UK.
Specific decrease of Th1-like activity in mice with plasma cell tumors.: Int Immunol. 1995 Jul;7(7):1029-35. Unique Identifier : AIDSLINE MED/96134426; Ruzek MC; Mathur A; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA.; Previously we examined the ability of the host s immune responses to regulate Ig production in an IgE-secreting murine plasma cell tumor (B53). In the present study we have examined the reverse phenomenon, in that we have investigated the effects of this and other plasma cell tumors on the immune responses of their ho
Activation and re-activation potential of T cells responding to staphylococcal enterotoxin B.: Int Immunol. 1995 Jul;7(7):1065-77. Unique Identifier : AIDSLINE MED/96134430; Hamel ME; Eynon EE; Savelkoul HF; van Oudenaren A; Kruisbeek AM; Division of Immunology, The Netherlands Cancer Institute,; Amsterdam.; To elucidate the parameters that lead to superantigen induced non-responsiveness, an in vitro model for studying primary and secondary responses to the bacterial superantigen staphylococcal enterotoxin B (SEB) was established. Upon re-activation with SEB, in vitro SEB primed T cells show an early proliferative respons
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells.: Int Immunol. 1995 Jul;7(7):1135-45. Unique Identifier : AIDSLINE MED/96134437; Zou JP; Yamamoto N; Fujii T; Takenaka H; Kobayashi M; Herrmann SH; Wolf SF; Fujiwara H; Hamaoka T; Biomedical Research Center, Osaka University Medical School,; Japan.; Unfractionated spleen cells taken from tumor-bearing mice 2 weeks after tumor implantation contained tumor-primed T cells which produced cytokines including IL-2 and IFN-gamma when cultured in vitro. With progressive tumor growth this initial lymphokine-producing capac
Nosocomial tuberculosis: new progress in control and prevention.: Clin Infect Dis. 1995 Sep;21(3):489-505. Unique Identifier : AIDSLINE MED/96077363; McGowan JE Jr; Department of Pathology, Emory University School of; Medicine/Grady Memorial Hospital, Atlanta, Georgia 30335, USA.; Nosocomial cases of tuberculosis have affected both health care workers and hospitalized patients, and each group has transmitted the infection to the other. This situation has been exacerbated by increases in the number of patients concurrently infected with human immunodeficiency virus and organisms resistant to mul
Aspergillus sinusitis in patients with AIDS: report of three cases and review.: Clin Infect Dis. 1995 Sep;21(3):529-35. Unique Identifier : AIDSLINE MED/96077368; Teh W; Matti BS; Marisiddaiah H; Minamoto GY; Division of Allergy, Clinical Immunology, and Infectious; Diseases, St. Luke's/Roosevelt Hospital Center, New York, New; York 10025, USA.; Invasive aspergillosis is an uncommon but increasingly reported complication of AIDS. Sinusitis, usually bacterial in etiology, is frequently seen among human immunodeficiency virus (HIV)-infected patients. We discuss the cases of three patients with AIDS and invasive aspergillus sinusitis seen at our institutions and
Congenital Chagas' disease: diagnostic and clinical aspects.: Clin Infect Dis. 1995 Sep;21(3):551-5. Unique Identifier : AIDSLINE MED/96077372; Freilij H; Altcheh J; Parasitology Laboratory, Ricardo Gutierrez Children's Hospital,; Buenos Aires, Argentina.; The diagnostic and clinical aspects of congenital Chagas disease were studied in 71 children in Buenos Aires. The children s ages ranged from 2 days to 10 years. In infants
Transmission of zidovudine-resistant human immunodeficiency virus type 1 variants following deliberate injection of blood from a patient with AIDS: characteristics and natural history of the virus.: Clin Infect Dis. 1995 Sep;21(3):556-60. Unique Identifier : AIDSLINE MED/96077373; Veenstra J; Schuurman R; Cornelissen M; van't Wout AB; Boucher CA; Schuitemaker H; Goudsmit J; Coutinho RA; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, the Netherlands.; We describe the development and persistence of severe immunodeficiency in a previously healthy young woman shortly after she was deliberately injected with blood that was drawn from a patient with AIDS. The heterogenous populations of human immunodeficiency virus (HIV) in donor and recipient were as closely related as
Transmission of fluconazole-resistant Candida albicans between patients with AIDS and oropharyngeal candidiasis documented by pulsed-field gel electrophoresis.: Clin Infect Dis. 1995 Sep;21(3):561-4. Unique Identifier : AIDSLINE MED/96077374; Barchiesi F; Hollis RJ; Del Poeta M; McGough DA; Scalise G; Rinaldi MG; Pfaller MA; Department of Pathology, University of Texas Health Science; Center, San Antonio 78284-7750, USA.; Electrophoretic karyotype and restriction endonuclease analysis of genomic DNA were used for the typing of nine isolates of Candida albicans from the oral cavities of two patients with AIDS--a husband and wife--whose infections became resistant to treatment with fluconazole (400 mg/d). The in vitro susceptibilities of
Adverse events associated with high-dose rifabutin in macrolide-containing regimens for the treatment of Mycobacterium avium complex lung disease.: Clin Infect Dis. 1995 Sep;21(3):594-8. Unique Identifier : AIDSLINE MED/96077379; Griffith DE; Brown BA; Girard WM; Wallace RJ Jr; Department of Medicine, University of Texas Health Center, Tyler; 75710, USA.; We initiated a multidrug trial that included high-dose rifabutin for the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Twenty-six patients received rifabutin (600 mg/d) in combination with ethambutol, streptomycin, and either clarithromycin (500 mg b.i.d.; 15 patients) or azithromycin (600 mg/d; 11
Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men.: Clin Infect Dis. 1995 Sep;21(3):603-7. Unique Identifier : AIDSLINE MED/96077381; Forti RL; Medwell SJ; Aboulafia DM; Surawicz CM; Spach DH; Department of Medicine, University of Washington Medical Center,; Seattle, USA.; From January 1988 to December 1993, we identified six men with minimally invasive (stage I) squamous cell carcinoma of the anus and 10 men with anal carcinoma in situ (CIS). Of the six patients with invasive carcinoma, four were infected with human immunodeficiency virus (HIV), including one with AIDS. Of the 10 patie
Pulmonary cryptococcosis: localized and disseminated infections in 27 patients with AIDS.: Clin Infect Dis. 1995 Sep;21(3):628-33. Unique Identifier : AIDSLINE MED/96077385; Meyohas MC; Roux P; Bollens D; Chouaid C; Rozenbaum W; Meynard JL; Poirot JL; Frottier J; Mayaud C; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.; We reviewed the records of 85 patients infected with both human immunodeficiency virus and Cryptococcus neoformans. Twenty-seven patients (32%) had pulmonary cryptococcosis. C. neoformans was cultured from bronchoalveolar lavage (BAL) or pleural fluid in 25 cases; the remaining two patients had cryptococcal antigen (C
Emergence of multidrug resistance in Campylobacter jejuni isolates from three patients infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Sep;21(3):634-8. Unique Identifier : AIDSLINE MED/96077386; Tee W; Mijch A; Wright E; Yung A; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital, Victoria, Australia.; Single-drug resistance to tetracycline, doxycycline, erythromycin, or fluoroquinolones in Campylobacter isolates recovered from humans has been documented worldwide. Multidrug resistance to these antibiotics is rare in Campylobacter jejuni. We report the sequential development of multidrug resistance in C. jejuni isol
Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis.: Clin Infect Dis. 1995 Sep;21(3):656-8. Unique Identifier : AIDSLINE MED/96077391; Caumes E; Bocquet H; Guermonprez G; Rogeaux O; Bricaire F; Katlama C; Gentilini M; Departement des Maladies Infectieuses, Parasitaires, Tropicales,; et Sante Publique, Hopital Pitie-Salpetriere, Paris, France.; We assessed the value of clinical and laboratory parameters for predicting the occurrence of skin reactions induced by pyrimethamine/sulfadiazine and pyrimethamine/clindamycin and the effects of continued therapy for patients with these reactions. We retrospectively studied all episodes of toxoplasmic encephalitis in
Atypical leishmaniasis in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Sep;21(3):663-5. Unique Identifier : AIDSLINE MED/96077393; Mondain-Miton V; Toussaint-Gari M; Hofman P; Marty P; Carles M; De Salvador F; Miton F; Le Fichoux Y; Dellamonica P; Service des Maladies Infectieuses et Tropicales, Hopital de; l'Archet, Nice, France.; Visceral leishmaniasis is an anthropozoonosis endemic in the south of France . Its occurrence among patients infected with human immunodeficiency virus (HIV), in whom it presents with uncommon clinical, biological, and evolutionary signs, is being reported more and more often. We de
Rethinking CD4+ T cell counts for individuals who recently seroconverted to human immunodeficiency virus.: Clin Infect Dis. 1995 Sep;21(3):666-8. Unique Identifier : AIDSLINE MED/96077394; Weiss PJ; Wallace MR; Department of Internal Medicine, Naval Medical Center, San Diego,; California, USA.; The distribution of initial CD4+ T lymphocyte counts for individuals who have recently seroconverted to human immunodeficiency virus (HIV) is broad. We review major articles describing CD4 cell counts shortly after documented HIV infection and discuss both the possible sources of variability in these studies and the c
Prolonged isolated fever due to attenuated extracerebral toxoplasmosis in patients infected with human immunodeficiency virus who are receiving trimethoprim-sulfamethoxazole as prophylaxis.: Clin Infect Dis. 1995 Sep;21(3):680-1. Unique Identifier : AIDSLINE MED/96077399; Zylberberg H; Robert F; Le Gal FA; Dupouy-Camet J; Zylberberg L; Viard JP; Service d'Immunologie Clinique, Hopital Necker, Paris, France.; We report two cases of prolonged fever in deeply immunocompromised patients with AIDS who had been receiving trimethoprim-sulfamethoxazole (TMP-SMZ) as primary prophylaxis for several months. Investigations of the cause of fever yielded normal or negative findings except that the polymerase chain reaction (PCR) for To
Cholera in a patient infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1995 Sep;21(3):689-90. Unique Identifier : AIDSLINE MED/96077402; Dahdouh MA; Ismail A; Berger JJ
Pneumonia and respiratory distress syndrome during primary infection with Toxoplasma gondii [letter]: Clin Infect Dis. 1995 Sep;21(3):690-1. Unique Identifier : AIDSLINE MED/96077403; Renold C; wintsch J; Filthuth I; Wunderli W; Lew D; Hirschel B
Pneumococcal soft-tissue infections [letter; comment]: Clin Infect Dis. 1995 Sep;21(3):697-8. Unique Identifier : AIDSLINE MED/96077408; Cuenca-Estrella M; Ramos JM; Esteban J; Soriano F
Elevated cytokine levels in a patient with AIDS and hypercalcemia: effects of therapy with pamidronate [letter]: Clin Infect Dis. 1995 Sep;21(3):699. Unique Identifier : AIDSLINE MED/96077410; Carbone LD; Land MA; Stentz FB; Palmieri GM
Visceral leishmaniasis due to a Leishmania variant that shares kinetoplast DNA sequences with Leishmania braziliensis and Leishmania mexicana in a patient infected with human immunodeficiency virus: identification of the Leishmania species with use of the polymerase chain reaction [letter]: Clin Infect Dis. 1995 Sep;21(3):701-2. Unique Identifier : AIDSLINE MED/96077412; Hernandez DE; Rodriguez N; Wessolossky M; Convit J
Reversible CD4+ T lymphocyte depletion in a patient who had disseminated histoplasmosis and who was not infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1995 Sep;21(3):702-3. Unique Identifier : AIDSLINE MED/96077413; Rhew DC; Goetz MB; Louie MH
Update on the status of Lyme borreliosis in British Columbia, Canada [letter]: Clin Infect Dis. 1995 Sep;21(3):704. Unique Identifier : AIDSLINE MED/96077414; Banerjee S
Bacteremic group A streptococcal pharyngitis presenting as acute airway obstruction [letter]: Clin Infect Dis. 1995 Sep;21(3):704-5. Unique Identifier : AIDSLINE MED/96077415; Gradon JD; Adamson C
Pancreatic necrosis following treatment of leishmaniasis with sodium stibogluconate [letter; comment]: Clin Infect Dis. 1995 Sep;21(3):710. Unique Identifier : AIDSLINE MED/96077420; McBride MO; Linney M; Davidson RN; Weber JN
Efficacy of intermittent liposomal amphotericin B in the treatment of visceral leishmaniasis in patients infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1995 Sep;21(3):711-2. Unique Identifier : AIDSLINE MED/96077421; Laguna F; Torre-Cisneros J; Moreno V; Villanueva JL; Valencia E
Legionnaires' disease in patients infected with human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1995 Sep;21(3):712-3. Unique Identifier : AIDSLINE MED/96077422; Gutierrez Rodero F; Ortiz de la Tabla V; Martinez C; Masia MM; Chiner E; Calpe JL
Intrathecal synthesis of antibodies to human herpesvirus 6 early antigen in patients with meningitis/encephalitis [letter]: Clin Infect Dis. 1995 Sep;21(3):715-6. Unique Identifier : AIDSLINE MED/96077425; Patnaik M; Peter JB
Large-scale production of HIV-1 protease from Escherichia coli using selective extraction and membrane fractionation.: Protein Expr Purif. 1995 Aug;6(4):512-8. Unique Identifier : AIDSLINE MED/96136639; Gustafson ME; Junger KD; Foy BA; Baez JA; Bishop BF; Rangwala SH; Michener ML; Leimgruber RM; Houseman KA; Mueller RA; et al; G.D. Searle and Co., Chesterfield, Missouri 63198, USA.; Human immunodeficiency virus type 1 (HIV-1) protease was expressed in Escherichia coli as a fusion protein with the N-terminal sequence of IGF-2. The protein accumulated in inclusion bodies as a 40:60 mixture of unprocessed fusion protein and processed protein. A simple purification procedure was developed that yielde
Immunology of human helminth infection.: Int Arch Allergy Immunol. 1996 Jan;109(1):3-10. Unique Identifier : AIDSLINE MED/96127913; Allen JE; Maizels RM; Institute of Cell, Animal and Population Biology, University of; Edinburgh, UK.; Parasitic helminths cause enormous morbidity among humans especially in developing countries. These large extracellular organisms have complex life cycles frequently involving an arthropod vector. Helminth parasites can be tissue dwelling or intestinal but all induce a dramatic expansion of the Th2 lymphocyte subset.
Clinical experience with fludarabine and its immunosuppressive effects in pretreated chronic lymphocytic leukemias and low-grade lymphomas.: Leuk Lymphoma. 1995 Aug;18(5-6):485-92. Unique Identifier : AIDSLINE MED/96116890; Fenchel K; Bergmann L; Wijermans P; Engert A; Pralle H; Mitrou PS; Diehl V; Hoelzer D; Medical Clinic III, J. W. Goethe University, Frankfurt/M.,; Federal Republic of Germany.; Fludarabine monophosphate (FAMP) is a new adenine nucleoside analogue with a promising efficacy in B-cell chronic lymphocytic leukemia (B-CLL) and low-grade non-Hodgkin lymphomas (NHLs). Here, the clinical experience and side effects with FAMP are reported in 77 patients with pretreated CLL (59 B-CLL, 2 T-CLL) and low
Immunoblastic transformation of a Sezary syndrome in a black Caribbean patient without evidence of HTLV-I.: Leuk Lymphoma. 1995 Aug;18(5-6):521-7. Unique Identifier : AIDSLINE MED/96116896; Matutes E; Schulz T; Dyer M; Ellis J; Hedges M; Catovsky D; Academic Department of Haematology and Cytogenetics, Royal; Marsden Hospital, London, U.K.; We describe an unusual case of Sezary syndrome which transformed into a large T-cell non Hodgkin s lymphoma (immunoblastic) in a black man of Caribbean descent with negative HTLV-I serology and no evidence of HTLV-I infection by DNA analysis using sensitive techniques. The disease presented as a small-cell Sezary synd
A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design.: Protein Sci. 1995 Sep;4(9):1881-903. Unique Identifier : AIDSLINE MED/96100655; Wallqvist A; Jernigan RL; Covell DG; Frederick Cancer Research and Development Center, National Cancer; Institute, Frederick, Maryland 21702, USA.; The interface between protein receptor-ligand complexes has been studied with respect to their binary interatomic interactions. Crystal structure data have been used to catalogue surfaces buried by atoms from each member of a bound complex and determine a statistical preference for pairs of amino-acid atoms. A simple
Human immunodeficiency virus type 1 integrase stabilizes a linearized HIV-1 LTR plasmid in vivo.: Biochem Mol Biol Int. 1995 Jul;36(4):745-58. Unique Identifier : AIDSLINE MED/96057063; Faust EA; Acel A; Udashkin B; Wainberg MA; Lady Davis Institute for Medical Research, SMBD-Jewish General; Hospital, Montreal, Quebec, Canada.; A mammalian expression vector designed for production of HIV-1 integrase was found to enhance the stability of a linear reporter plasmid in COS-7 cells. The effect is strictly dependent on coexpression of the HIV-1 rev gene and on the inclusion of U3 and U5 portions of the HIV-1 LTR in the reporter plasmid. Integrase
Customer service. Insights from playing patient.: Hosp Health Netw. 1995 Nov 20;69(22):50. Unique Identifier : AIDSLINE MED/96135893; Turner S
Public health. AIDS invades rural Maine.: Hosp Health Netw. 1995 Dec 5;69(23):60, 62. Unique Identifier : AIDSLINE MED/96132238; MacPherson P
AIDS and HIV-1 infection worldwide.: Commun Dis Rep CDR Wkly. 1995 Nov 17;5(46):253-4. Unique Identifier : AIDSLINE MED/96107932
Human herpesvirus 6 as a potential copathogen.: Trends Microbiol. 1995 Aug;3(8):324-7. Unique Identifier : AIDSLINE MED/96021568; Ablashi DV; Bernbaum J; DiPaolo JA; Advanced Biotechnologies, Inc., Columbia, MD 21046, USA.; The molecular, biological and immunological studies of the recently identified human herpesvirus 6 (HHV-6) suggest that the virus is involved in the etiology of at least three lymphoproliferative diseases. Furthermore, HHV-6 may be an important cofactor in the pathogenesis of several other diseases, including HIV-asso
SIV infection of monkey spleen cells including follicular dendritic cells in different stages of disease.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):1-9. Unique Identifier : AIDSLINE MED/96130041; Stahmer I; Ordonez C; Popovic M; Mesquita R; Ekman M; Albert J; Putkonen P; Bottiger D; Biberfeld G; Biberfeld P; Immunopathology Laboratory, Karolinska Institute, Stockholm,; Sweden.; Immunoaffinity enriched spleen follicular dendritic cells (FDCs), lymphocytes, and macrophages from SIVsm-inoculated cynomolgus monkeys (Macaca fascicularis) at different stages of disease were compared for latent and productive SIV infection. Analysis of FDCs by in situ hybridization, electron microscopy, and cocultu
Characterization of an antigen shared by human thymic epithelium and human T cell leukemia virus p19 Gag protein.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):10-9. Unique Identifier : AIDSLINE MED/96130042; Palker TJ; Singer KH; Vahlne A; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, USA.; The molecular basis for cross-reactive antibody binding to human T cell leukemia virus type I (HTLV-I) p19 core protein and human thymic epithelium has been defined with two monoclonal antibodies (mAbs), 12/1-2 and 13B12, raised to HTLV-I p19. The mAb 12/1-2 has previously been shown to react with HTLV-I p19, HTLV-II
Low HTLV-I/II seroprevalence in pregnant women in Congo and a geographic cluster of an HTLV-like indeterminate western blot pattern [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):105-7. Unique Identifier : AIDSLINE MED/96130054; Tuppin P; Makuwa M; Guerma T; Bazabana MM; Loukaka JC; Jeannel D; M'Pele P; de The G
Recombinant human immunodeficiency virus type 1 reverse transcriptase is heterogeneous.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):20-30. Unique Identifier : AIDSLINE MED/96130043; Wilson JE; Wright LL; Martin JL; Haire SE; Ray PH; Painter GR; Furman PA; Division of Biochemistry, Burroughs Wellcome Co., Research; Triangle Park, North Carolina, USA.; Recombinant wild type (wt) and T215Y HIV-1 reverse transcriptase (RT) were isolated using three methods designated A, B, and C. The three samples of wt RT were kinetically indistinguishable with respect to dTTP turnover on poly(rA).p(dT)10. However, whereas the kinetic constants for dTTP and AZTTP for both T215Y B and
Human antibody variable region gene usage in HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):31-8. Unique Identifier : AIDSLINE MED/96130044; Wisnewski A; Cavacini L; Posner M; Department of Medicine, New England Deaconess Hospital, Boston; 02215, USA.; Human antibody variable region gene usage during human immunodeficiency virus type 1 (HIV-1) infection is examined in the following review, and several hypotheses are presented to account for the distinct patterns of antibody gene expression associated with infection. Evidence supporting qualitatively biased antibody
Epidemiology of AIDS dementia complex in Europe. AIDS in Europe Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):39-44. Unique Identifier : AIDSLINE MED/96130045; Chiesi A; Vella S; Dally LG; Pedersen C; Danner S; Johnson AM; Schwander S; Goebel FD; Glauser M; Antunes F; et al; Instituto Superiore di Sanita, Laboratory of Virology, Rome,; Italy.; The aim of the study was to describe the epidemiology of AIDS dementia complex (ADC) in Europe and to assess the possible role of zidovudine therapy in preventing or delaying its occurrence. We used an inception cohort, with data collected retrospectively from patients clinical re
Zidovudine side effects as reported by black, Hispanic, and white/non-Hispanic patients with early HIV disease: combined analysis of two multicenter placebo-controlled trials.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):45-52. Unique Identifier : AIDSLINE MED/96130046; Jacobson MA; Gundacker H; Hughes M; Fischl M; Volberding P; Department of Medicine, University of California San Francisco,; USA.; The objective of this study was to determine whether HIV patients subjective tolerance of zidovudine differs by racial or ethnic grouping by conducting a post hoc analysis of reported symptoms in two multicenter, placebo-controlled trials of zidovudine monotherapy for early HIV disease. Ratios of rates of developing
Mycobacterial infection in Mexican AIDS patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):53-8. Unique Identifier : AIDSLINE MED/96130047; Molina-Gamboa JD; Ponce-de-Leon S; Sifuentes-Osornio J; Bobadilla del Valle M; Ruiz-Palacios GM; Department of Infectious Diseases, National Institute of; Nutrition, Mexico City, Mexico.; To describe the characteristics of mycobacterial infection in Mexico, we reviewed records from patients who were seen at the AIDS Clinic of the National Institute of Nutrition in Mexico City from 1983 to 1992. Of 460 AIDS patients, 118 (25.6%) were found to have mycobacterial infections by positive Ziehl-Neelsen stain
In vivo role of IL-6 on the viral load and on immunological abnormalities of HIV-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):59-68. Unique Identifier : AIDSLINE MED/96130048; Marfaing-Koka A; Aubin JT; Grangeot-Keros L; Portier A; Benattar C; Merrien D; Agut H; Aucouturier P; Autran B; Wijdenes J; et al; INSERM U131, Institut Paris-Sud sur les Cytokines, Clamart,; France.; In vitro experiments have suggested that interleukin (IL)-6 may contribute to human immunodeficiency virus (HIV) burden and to immunological abnormalities in HIV-infected patients. We had the opportunity to directly address this question in vivo through the virological and immunological monitoring of HIV-infected pati
Back-projection and sensitivity analysis of the HIV-AIDS epidemic in the Caribbean.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):69-76. Unique Identifier : AIDSLINE MED/96130049; Newton EA; Farley JD; Gayle C; Special Program on Sexually Transmitted Diseases, Caribbean; Epidemiology Centre (CAREC/PAHO/WHO), Port of Spain, Trinidad,; West Indies.; In this study we estimated past human immunodeficiency virus (HIV) incidence in 19 nations in the primarily English-speaking Caribbean and projected the course of the epidemic to the year 1999. We compared the results obtained from several different models of HIV incidence and different assumed incubation distribution
Survival of AIDS patients in the emerging epidemic in Bangkok, Thailand.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):77-82. Unique Identifier : AIDSLINE MED/96130050; Kitayaporn D; Tansuphaswadikul S; Lohsomboon P; Pannachet K; Kaewkungwal J; Limpakarnjanarat K; Mastro TD; HIV/AIDS Collaboration, Nonthaburi, Thailand.; Survival from the time of AIDS diagnosis to death was determined retrospectively among Thai patients (> or = 13 years old) who attended a public tertiary care infectious disease hospital in a suburb of Bangkok, Thailand , from February 1987 through February 1993. An AIDS diagnosis
Epidemiology of AIDS among Hispanics in Chicago.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):83-7. Unique Identifier : AIDSLINE MED/96130051; Murphy J; Mueller G; Whitman S; AIDS Surveillance and Epidemiology Programs, Chicago Department; of Public Health, Illinois 60604-3972, USA.; The purpose of this study was to describe the epidemiology of AIDS among Hispanics in Chicago. These data are needed to tailor prevention and treatment programs across diverse Hispanic ethnic subgroups. To pursue Hispanic origin for the 1,289 Hispanic persons diagnosed with AIDS in Chicago, death certificates for thos
Mode of delivery and gestational age influence perinatal HIV-1 transmission. Italian Register for HIV Infection in Children.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):88-94. Unique Identifier : AIDSLINE MED/96130052; Tovo PA; de Martino M; Gabiano C; Galli L; Cappello N; Ruga E; Tulisso S; Vierucci A; Loy A; Zuccotti GV; et al; Department of Pediatrics, University of Turin, Italy.; Some data suggest that cesarean section reduces mother-to-child HIV-1 transmission. To assess the influence of mode of delivery and other maternal and infant factors on the rate of transmission, we analyzed the data of 1,624 children prospectively followed from birth. Of these, at the last visit 1,033 were > 18 months
Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):95-104. Unique Identifier : AIDSLINE MED/96130053; Krowka JF; Cuevas B; Maron DC; Steimer KS; Ascher MS; Sheppard HW; California Department of Health Services, Berkeley 94704, USA.; A flow cytometric assay based on expression of the activation antigen CD69 was developed to analyze immunological responses of T cells from human immunodeficiency virus (HIV)-infected (HIV+) or HIV-seronegative (HIV-) donors after in vitro simulation by antigens and polyclonal activators. The levels of CD69 on freshly
Physiologic and molecular aspects of the Na+/H+ exchangers in health and disease processes.: J Investig Med. 1995 Oct;43(5):419-30. Unique Identifier : AIDSLINE MED/96102464; Soleimani M; Singh G; Department of Medicine, Indiana University School of Medicine,; USA.
Lotteries set up for two experimental AIDS drugs [news]: Am J Health Syst Pharm. 1995 Sep 1;52(17):1848. Unique Identifier : AIDSLINE MED/96039045
Treatment of Kaposi's sarcoma with liposomal doxorubicin.: Am J Health Syst Pharm. 1995 Sep 15;52(18):2001-4. Unique Identifier : AIDSLINE MED/96083884; Bergin C; O'Leary A; McCreary C; Sabra K; Mulcahy F; Department of Genitourinary Medicine, St. James's Hospital,; Dublin, Ireland.; The efficacy of liposomal doxorubicin for treating Kaposi s sarcoma (KS) in patients infected with human immunodeficiency virus (HIV) was studied. Eight men with HIV infection and KS were to be given liposomal doxorubicin 20 mg/sq m i.v. monthly for six months and 10 mg/sq m i.v. monthly thereafter, depending on the r
Plasma concentration of cytokine antagonists in patients with HIV infection.: Neuroimmunomodulation. 1994 Jan;1(1):42-9. Unique Identifier : AIDSLINE MED/96053011; Catania A; Manfredi MG; Airaghi L; Vivirito MC; Capetti A; Milazzo F; Lipton JM; Zanussi C; First Medical Clinic, University of Milan, Italy.; There is increasing evidence that cytokines contribute to the immunopathogenesis of human immunodeficiency virus (HIV) infection. It may be, therefore, that compensatory rises in circulating cytokine antagonists also occur in HIV infection and that such changes mark disease progression. To test this idea, plasma conce
Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.: Mol Med. 1995 Jan;1(2):217-30. Unique Identifier : AIDSLINE MED/96091345; Dubrovsky L; Ulrich P; Nuovo GJ; Manogue KR; Cerami A; Bukrinsky M; Picower Institute for Medical Research, Manhasset, New York; 11030, USA.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrophage lineage. This feature relies on the presence of a specific nuclear localization signal (NLS)
HIV accessory proteins: emerging therapeutic targets.: Mol Med. 1995 Jul;1(5):479-85. Unique Identifier : AIDSLINE MED/96091372; Miller RH; Sarver N; Targeted Interventions Branch, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-7620, USA.
Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases.: Mol Med. 1995 Sep;1(6):614-24. Unique Identifier : AIDSLINE MED/96091385; Monteiro J; Hingorani R; Choi IH; Silver J; Pergolizzi R; Gregersen PK; Department of Medicine, North Shore University Hospital/Cornell; University Medical Center, Manhasset, New York, USA.; BACKGROUND: We have previously demonstrated CD8+ T cell clonal dominance using a PCR assay for the CDR3 length of T cell receptors belonging to a limited number of TCRBV segments/families. In this study, we have modified this approach in order to analyze more comprehensively the frequency of oligoclonality in the CD8+
Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.: Mol Med. 1995 Sep;1(6):667-77. Unique Identifier : AIDSLINE MED/96091390; Granowitz EV; Saget BM; Wang MZ; Dinarello CA; Skolnik PR; Department of Medicine, New England Medical Center Hospitals,; Boston, MA 02111, USA.; BACKGROUND: Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An understanding of these cytokine networks may suggest novel treatment strategies for HIV-seropositive persons. MATERIALS AND METHODS: U1 cells, a chronicall
AIDS networking in Canada, US [news]: Can Med Assoc J. 1995 Dec 15;153(12):1772. Unique Identifier : AIDSLINE MED/96124860
Variability in leukocyte subset measurements among five laboratories in Vancouver.: Clin Invest Med. 1995 Oct;18(5):349-56. Unique Identifier : AIDSLINE MED/96120807; Mandigo K; Raboud JM; Haley L; Montaner JS; Canadian HIV Trials Network, Department of Health Care and; Epidemiology, Faculty of Medicine, University of British; Columbia, Vancouver.; Cell counts and percentages of CD4 are widely used in the prognostic and clinical management of HIV-infected patients, and as surrogate outcomes in clinical trials involving HIV-infected individuals. Considerable variability in CD4 counts has been documented due to physiologic and methodologic factors. While studies o
Challenging consults: application of principles of physiology and biochemistry to the bedside. Osmotic diuresis: the importance of counting the number of osmoles excreted.: Clin Invest Med. 1995 Oct;18(5):401-5. Unique Identifier : AIDSLINE MED/96120813; Levin A; Klassen J; Halperin ML; Renal Division, St. Paul's Hospital, University of British; Columbia, Vancouver.; Polyuria is usually the result of a water diuresis or an osmotic diuresis. Traditionally, the assessment of the extracellular fluid (ECF) volume and the concentration of Na+ in plasma is sufficient to differentiate between the two. We present a case and our approach, which is based on calculations and quantitation of
Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU).: Curr Eye Res. 1995 Aug;14(8):703-10. Unique Identifier : AIDSLINE MED/96002868; Kim MC; Kabeer NH; Tandhasetti MT; Kaplan HJ; Bora NS; Department of Ophthalmology and Visual Sciences, Washington; University School of Medicine, St Louis, MO 63110, USA.; Experimental autoimmune anterior uveitis (EAAU), a model of uveitis induced by sensitization to melanin associated antigen (MAA) derived from the iris and ciliary body, closely resembles human acute anterior uveitis. The immunopathogenesis of EAAU was studied by immunohistochemical detection of immune cells and the ex
A novel function of islet-derived CD8+T cells in initiating and developing autoimmune insulin-dependent diabetes mellitus in non-obese diabetic (NOD) mice.: Diabetes Res Clin Pract. 1995 Jun;28(3):161-72. Unique Identifier : AIDSLINE MED/96105588; Amano K; Yokono K; Hasegawa Y; Taki T; Tominaga Y; Yoneda R; Nagata M; Kasuga M; Second Department of Internal Medicine, Kobe University School of; Medicine, Japan.; Accumulated studies revealed that CD4+T cells were initially required for diabetes in NOD mice, whereas interaction of CD4+T/CD8+T cells is not fully understood. To address this question, we established islet-derived CD4+T cells and CD8+T cells from NOD mice. One NOD neonate that received CD4+T cells developed diabete
Validity of intravenous drug abusers' self-reported changes in HIV high-risk drug use behaviors.: Drug Alcohol Depend. 1995 Aug;39(2):91-8. Unique Identifier : AIDSLINE MED/96098401; Greenfield L; Bigelow GE; Brooner RK; Behavioral Pharmacology Research Unit, Johns Hopkins University; School of Medicine, Baltimore, MD 21224, USA.; The HIV-1 high-risk drug use behavior of intravenous drug abusers was assessed both retrospectively (for 6 months) and prospectively (for 6 months) via structured interview and urinalysis testing. Subjects were 281 intravenous drug abusers, 146 enrolled in outpatient methadone treatment (Treatment group) and 135 not i
Passive HIV-hyperimmunoglobulin therapy in paediatric AIDS [letter]: Eur J Pediatr. 1995 Oct;154(10):865. Unique Identifier : AIDSLINE MED/96105650; Kreuz W; Gungor T; Beeg T; Linde R; Mentzer D; Kornhuber B
Preventive and therapeutic AIDS peptide vaccines.: Eur J Pediatr. 1995;154(9 Suppl 4):S28-9. Unique Identifier : AIDSLINE MED/96064067; Rubinstein A; Cryz S; Albert Einstein College of Medicine, Division of Pediatric; Allergy and Immunology, Bronx, NY 10461, USA.
Mycobacterium genavense invasive infection in two children with AIDS: long-term followup.: Eur J Pediatr. 1995;154(9 Suppl 4):S74-6. Unique Identifier : AIDSLINE MED/96064076; Reymond D; Birrer P; Schaad UB; Department of Paediatrics, University Hospital, Inselspital,; Berne, Switzerland.; Mycobacterium genavense is a rare cause of opportunistic infection in immunocompromised hosts. Follow up of two cases of M. genavense invasive infection in children with haemophilia A and AIDS are presented. One patient died 18 months after diagnosis of M. genavense infection of an indirectly related cause, probably o
Acute cardiotoxicity of the Anti-HIV dideoxynucleoside, F-ddA, in the rat.: Fundam Appl Toxicol. 1995 Sep;27(2):167-76. Unique Identifier : AIDSLINE MED/96077634; Donzanti BA; Kelley JA; Tomaszewski JE; Roth JS; Tosca P; Placke M; Singer A; Yarrington JT; Driscoll JS; Battelle Memorial Institute, Columbus, Ohio 43201, USA.; 2 -beta-Fluoro-2 ,3 -dideoxyadenosine (F-ddA), an acid-stable, purine dideoxynucleoside with in vitro anti-HIV activity, has been selected by the NCI as a clinical trial candidate. A recent report that high, single doses of F-ddA produce cardiotoxicity in rats prompted the present investigation whose objective was to
TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.: FASEB J. 1995 Dec;9(15):1577-84. Unique Identifier : AIDSLINE MED/96118455; Benveniste EN; Benos DJ; Department of Cell Biology, University of Alabama at Birmingham; 35294-0005, USA.; Cytokines are a group of secreted proteins that display diverse biological activity. They are especially important in the body s response to injury. They subserve a variety of both autocrine and paracrine functions by activating numerous intracellular second-messenger signaling pathways. Cytokines are known to mediate
Low birth weight and genital infections. An incident case-referent study.: Gynecol Obstet Invest. 1995;40(3):183-9. Unique Identifier : AIDSLINE MED/96121445; Bique Osman N; Folgosa E; Gonzalez C; Bergstrom S; Department of Obstetrics and Gynaecology, Central Hospital,; Maputo, Mozambique.; In an attempt to elucidate the potential association between genital infections and low birth weight (LBW) births, 51 women with LBW neonates were identified and compared to 51 women with normal birthweight (NBW) neonates. Both groups were matched according to age and parity. All women were subjected to interviews reg
[Vaccines against AIDS finally in sight? Vaccination campaigns in China and Uganda in preliminary stages (news)]: Fortschr Med. 1995 Nov 10;113(31):20, 22. Unique Identifier : AIDSLINE MED/96092189; Wolf HJ
Insights for improving patient care [letter; comment]: Image J Nurs Sch. 1995 Winter;27(4):257. Unique Identifier : AIDSLINE MED/96107987; Deines R; Mount C; Peppard LS; Skinner NL
[Viruses and cancer: molecular pathologic mechanisms of viral carcinogenesis]: Immun Infekt. 1995 Oct;23(5):179-84. Unique Identifier : AIDSLINE MED/96091789; Butz K; Hoppe-Seyler F; Forschungsschwerpunkt Angewandte Tumorvirologie, Abteilung; Virus-Wirtszell-Wechselwirkungen, Deutsches; Krebsforschungszentrum Heidelber.; At least 15% of the human cancer incidence is caused by an infection with human tumor viruses. The recent progress of experimental cancer research led to important new concepts about the pathomechanisms of viral carcinogenesis. The functional inactivation of cellular tumor suppressor proteins by viral factors appears
Activation of NF-kappa B by the Tax protein of HTLV-1.: Immunobiology. 1995 Jul;193(2-4):128-36. Unique Identifier : AIDSLINE MED/96030032; Munoz E; Israel A; Unite de Biologie Moleculaire de l'Expression Genique,; Institut Pasteur, Paris, France.; The Tax protein, encoded by the human T cell leukemia virus HTLV-1, is responsible for transcriptional activation of the viral genome through conserved 21bp repeats located in its promoter. Tax also activates the transcription of cellular genes such as interleukin 2, interleukin 2 receptor (IL2R), GM-CSF, vimentin, c-
TNF-induced activation of NF-kappa B.: Immunobiology. 1995 Jul;193(2-4):193-203. Unique Identifier : AIDSLINE MED/96030040; Schutze S; Wiegmann K; Machleidt T; Kronke M; Institut fur Medizinische Mikrobiologie und Hygiene, Technische; Universitat Munchen, Germany.; Tumor Necrosis Factor (TNF) is one of the most potent physiological inducers of the nuclear transcription factor NF-kappa B. In light of the pivotal role of NF-kappa B in the development of immune responses and activation of HIV replication, the identification of TNF signal transduction pathways involved in NF-kappa B
Influence of redox status of lymphocytes and monocytes on HIV transcription and replication.: Immunobiology. 1995 Jul;193(2-4):204-9. Unique Identifier : AIDSLINE MED/96030041; Gougerot-Pocidalo MA; Aillet F; Virelizier JL; Israel N; Unite INSERM U 294, Hopital Bichat, Paris, France.
Is there a relationship between heavy drinking and HIV high risk sexual behaviors among general population subjects?: Int J Addict. 1995 Sep;30(11):1453-78. Unique Identifier : AIDSLINE MED/96093042; Shillington AM; Cottler LB; Compton WM 3rd; Spitznagel EL; Department of Sociology, Social Work and Anthropology, Utah State; University, Logan 84322, USA.; The authors investigated the association between heavy drinking and sexual behaviors among 2,581 general population subjects from the St. Louis Epidemiologic Catchment Area survey conducted from 1981 to 1983. Lifetime sexual behaviors included promiscuity, infidelity, receiving money for sex, and same gender sex. It w
Intra-abdominal tuberculosis in acquired immunodeficiency syndrome. Diagnosis and management.: Int Surg. 1995 Apr-Jun;80(2):147-51. Unique Identifier : AIDSLINE MED/96098505; Schanaider A; Madi K; Department of Surgery and Pathology, Federal University of Rio de; Janeiro, Brazil.; Tuberculosis (TB) in human immunodeficiency virus (HIV) immunosuppressed patients is characterized by extra-pulmonary disease in as many of 70% of them. If intestinal or lymph node involvement occurs, the differential diagnosis between an acute abdomen and other non surgical conditions may be a challenging problem. Th
Animal organs for human patients?: Hastings Cent Rep. 1995 Sep-Oct;25(5):4. Unique Identifier : AIDSLINE MED/96097322; Palca J
Baboon marrow transplant given OK [news]: Hastings Cent Rep. 1995 Sep-Oct;25(5):47. Unique Identifier : AIDSLINE MED/96097331
The seductive sirens of medical progress. The case of xenotransplantation.: Hastings Cent Rep. 1995 Sep-Oct;25(5):5-6. Unique Identifier : AIDSLINE MED/96097323; Hanson MJ
Development of drug resistance to HIV-1 protease inhibitors.: J Biol Chem. 1995 Dec 15;270(50):29621-3. Unique Identifier : AIDSLINE MED/96101998; Ridky T; Leis J; Case Western Reserve University, School of Medicine, Cleveland,; Ohio 44106-4935, USA.
T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infection.: J Biol Chem. 1995 Dec 15;270(50):29690-7. Unique Identifier : AIDSLINE MED/96102014; Bofil M; Fairbanks LD; Ruckemann K; Lipman M; Simmonds HA; Academic Department of Clinical Immunology, Royal Free Hospital; School of Medicine, London, United Kingdom.; Proliferative defects have been reported at the level of DNA synthesis, even in T-lymphocytes from asymptomatic human immunodeficiency virus type-1+ (HIV-1+) patients. Since purine and pyrimidine ribonucleotide availability is crucial for proliferation, we compared the ability of HIV-1- and HIV-1+ T-lymphocytes (> 95%
RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA.: J Biol Chem. 1995 Dec 22;270(51):30448-52. Unique Identifier : AIDSLINE MED/96107197; Shen Q; McQuilkin PA; Newburger PE; Department of Pediatrics, University of Massachusetts Medical; School, Worcester 01655, USA.; Translational incorporation of the unusual amino acid selenocysteine in eukaryotes requires a coding region UGA codon (which otherwise serves as a termination signal), a selenocysteine insertion sequence (SECIS) in the 3 -untranslated region of the mRNA, and selenocysteyl-tRNA. The mechanisms involved in SECIS recogni
Detection of HIV-1 infection in vitro using NASBA: an isothermal RNA amplification technique.: J Virol Methods. 1995 Aug;54(2-3):109-19. Unique Identifier : AIDSLINE MED/96038350; Romano JW; Shurtliff RN; Sarngadharan MG; Pal R; Advanced BioSciences Laboratories Inc., Kensington, MD 20895,; USA.; Establishment of a sensitive infection assay for HIV-1 is essential for successful screening of antiviral agents and neutralizing antibodies. In this report, an infection assay is described which measures the expression of viral genomic RNA and spliced mRNA intermediates in infected cells by an amplification-based tec
Fatal pancreatitis as a complication of therapy for HIV infection.: J Emerg Med. 1995 Sep-Oct;13(5):633-7. Unique Identifier : AIDSLINE MED/96079181; Pelucio MT; Rothenhaus T; Smith M; Ward DJ; Department of Emergency Medicine, Ronald Reagan Institute of; Emergency Medicine, George Washington University Medical Center,; Washington, District of Columbia, USA.; Acute pancreatitis in HIV-infected patients with or without AIDS has been reported with increasing frequency over the past several years. Drugs used to treat HIV-infected patients are often the cause. We report a case of a 46-year-old HIV-infected man who presented to the emergency department with abdominal pain and w
Moritz Kaposi: idiopathic pigmented sarcoma of the skin.: J Emerg Med. 1995 Sep-Oct;13(5):671-4. Unique Identifier : AIDSLINE MED/96079189; Sternbach G; Varon J; Emergency Medicine Service, Stanford University Medical Center,; California, USA.; Moritz Kaposi first published a description of the entity that bears his name in 1872, calling it idiopathic multiple pigmented sarcoma of the skin. For many years thereafter, Kaposi s sarcoma was considered to be a relatively rare, slow-growing malignancy, most commonly seen in middle-aged and elderly men. This chang
Individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection: high percentage of carriers of hepatitis B and C virus.: J Hepatol. 1995 Jul;23(1):14-20. Unique Identifier : AIDSLINE MED/96138890; Jilg W; Sieger E; Zachoval R; Schatzl H; Max-von-Pettenkofer-Institute for Hygiene and Medical; Microbiology, University of Munich, Germany.; BACKGROUND/AIMS: Several reports have unequivocally demonstrated that some individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection are chronic carriers of the hepatitis B virus. Nevertheless, conflicting data exist about the frequency of this phenomenon; it
T helper cell dichotomy to Candida albicans: implications for pathology, therapy, and vaccine design.: Immunol Res. 1995;14(2):148-62. Unique Identifier : AIDSLINE MED/96108418; Romani L; Cenci E; Menacci A; Bistoni F; Puccetti P; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; Acquired immunity to Candida albicans is believed to prevent mucosal colonization of adult immunocompetent individuals from progressing to symptomatic infection. Resistance to disease appears to correlate with the detection of delayed-type hypersensitivity responses in vivo and a T helper type 1 (Th1) cytokine secreti
HTLV 1 associated myelopathy and adult T cell leukaemia-lymphoma in the same patient: report of a case [letter]: J Neurol Neurosurg Psychiatry. 1995 Nov;59(5):560-1. Unique Identifier : AIDSLINE MED/96067323; Rajamani K; Rugman FP; Savant CS; Vakil SD
Central venous catheter infection with Rhodotorula minuta in a patient with AIDS taking suppressive doses of fluconazole.: J Med Vet Mycol. 1995 Jul-Aug;33(4):267-70. Unique Identifier : AIDSLINE MED/96034427; Goldani LZ; Craven DE; Sugar AM; Department of Medicine, Boston University Medical Center, MA; 02118, USA.; A case of Rhodotorula minuta central venous catheter infection with fungaemia is described in a patient with advanced acquired immunodeficiency syndrome (AIDS), HIV nephropathy, end-stage renal disease requiring haemodialysis, and a permanent Quinton catheter in place for 6 months. At the time of fungaemia, the patien
Efficiency of the flotation method in the isolation of Penicillium marneffei from seeded soil.: J Med Vet Mycol. 1995 Jul-Aug;33(4):271-3. Unique Identifier : AIDSLINE MED/96034428; Vanittanakom N; Mekaprateep M; Sriburee P; Vanittanakom P; Khanjanasthiti P; Department of Microbiology, Faculty of Medicine, Chiang Mai; University, Thailand.; The efficiency of a modified flotation method for the isolation of Penicillium marneffei from soils has been evaluated. About 80% was recovered from sterilized soil freshly seeded with P. marneffei (100 conidia/1.5 g soil). When seeded non-sterile soil was used (at least 100 seeded conidia/1.5 g soil), P. marneffei co
Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor.: J Pharmacol Exp Ther. 1995 Dec;275(3):1527-34. Unique Identifier : AIDSLINE MED/96108651; Chiba M; Nishime JA; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, Pennsylvania, USA.; L-754,394, N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarb- onyl )-4- [(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R- ) - phenylmethylpentanamide, is a potent and specific inhibitor of the human immune deficiency virus (HIV) protease. The drug selectively inhibited human liver micr
Neurotoxicity of the human immunodeficiency virus type 1 tat transactivator to PC12 cells requires the Tat amino acid 49-58 basic domain.: J Neurosci Res. 1995 Sep 1;42(1):34-40. Unique Identifier : AIDSLINE MED/96058753; Weeks BS; Lieberman DM; Johnson B; Roque E; Green M; Loewenstein P; Oldfield EH; Kleinman HK; Laboratory of Developmental Biology, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892, USA.; The acquired immunodeficiency syndrome (AIDS) frequently involves the central nervous system (CNS) and manifests as dementia due to encephalitis or diffuse neurodegeneration. Human immunodeficiency virus type 1 (HIV-1) proteins, potentially transported into the CNS by mononuclear i
Genital infections in the aetiology of late fetal death: an incident case-referent study.: J Trop Pediatr. 1995 Oct;41(5):258-66. Unique Identifier : AIDSLINE MED/96102585; Osman NB; Folgosa E; Gonzales C; Bergstrom S; Department of Obstetrics and Gynecology, Central Hospital,; Maputo, Mozambique.; Women with prelabour fetal death in the third trimester were recruited in order to study the association between intra-uterine death and maternal genital colonization of bacteria. Fifty-eight women with verified fetal death were compared with a group of 58 women matched for age, parity and gestational length (the firs
An incident case-referent study of threatening preterm birth and genital infection.: J Trop Pediatr. 1995 Oct;41(5):267-72. Unique Identifier : AIDSLINE MED/96102586; Osman NB; Folgosa E; Bergstrom S; Department of Obstetrics and Gynecology, Central Hospital,; Maputo, Mozambique.; A total of 53 pregnant Mozambican women identified as having painful uterine contractions in the preterm period were studied and compared to referents, matched for age, parity, and gestational length, without such contractions. Both groups were studied regarding socio-economic and obstetric background factors, current
Clinical crossroads: alcoholism and HIV infection [letter; comment]: JAMA. 1996 Jan 3;275(1):32-3. Unique Identifier : AIDSLINE MED/96127932; Zenilman JM; Rompalo AM; Jadack R
Depression and survival among HIV-infected persons [letter]: JAMA. 1996 Jan 3;275(1):35-6. Unique Identifier : AIDSLINE MED/96127936; Lyketsos CG; Hoover DR; Guccione M
HIV-1 shedding and chlamydial urethritis [letter; comment]: JAMA. 1996 Jan 3;275(1):36. Unique Identifier : AIDSLINE MED/96127937; Eron JJ Jr; Gilliam B; Fiscus S; Dyer J; Cohen MS
Risk factors for HIV-1 seroconversion among young men in northern Thailand.: JAMA. 1996 Jan 10;275(2):122-7. Unique Identifier : AIDSLINE MED/96134954; Celentano DD; Nelson KE; Suprasert S; Eiumtrakul S; Tulvatana S; Kuntolbutra S; Akarasewi P; Matanasarawoot A; Wright NH; Sirisopana N; Theetranont C; Department of Health Policy and Management, Johns Hopkins; University School of Hygiene and Public Health, Baltimore, Md; 21205, USA.; OBJECTIVE--To identify behavioral and sociodemographic risk factors for incident human immunodeficiency virus-1 (HIV-1) infection among healthy young men in northern Thailand . DESIGN--Men inducted into military service in northern Thailand in May and November 1991 were followed a
Ocular manifestations of AIDS [clinical conference] [see comments]: JAMA. 1996 Jan 10;275(2):142-4. Unique Identifier : AIDSLINE MED/96134957; Whitcup SM; Clinical Branch, National Eye Institute, National Institutes of; Health, Bethesda, Md 20892-1858, USA.
Therapy for cytomegalovirus retinitis: still no silver lining [editorial; comment]: JAMA. 1996 Jan 10;275(2):149-50. Unique Identifier : AIDSLINE MED/96134960; Young LH
Several new drugs shift direction of treatment and research for HIV/AIDS [news]: JAMA. 1996 Jan 10;275(2):89-90. Unique Identifier : AIDSLINE MED/96134935; Voelker R
[Detection of retrovirus in salivary glands of patients with Sjogren's syndrome]: Nippon Rinsho. 1995 Oct;53(10):2456-60. Unique Identifier : AIDSLINE MED/96021737; Yamano S; Saito I; Department of Oral Surgery, Tokyo Medical College.; As similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV) and human T lymphotropic virus type I (HTLV-I), a search was initiated for a possible retroviral etiology in Sjogren s syndrome (SS). Sera from 33% of 15 SS patients reacted against p24 (gag) of
[Exocrinopathy resembling Sjogren's syndrome induced by a murine retrovirus]: Nippon Rinsho. 1995 Oct;53(10):2461-6. Unique Identifier : AIDSLINE MED/96021738; Suzuki K; Fujiwara M; Third Department of Internal Medicine, Niigata University.; Recently, retrovirus is suggested to participate in the pathogenesis of Sjogren s syndrome (SjS). During the course of our study on mice infected with LP-BM5 murine leukemia virus, we found SjS-like systemic exocrinopathy in those mice. This virus is known to induce murine acquired immunodeficiency syndrome (MAIDS) in
[HTLV-I infection in primary Sjogren's syndrome--epidemiological, clinical and virological studies]: Nippon Rinsho. 1995 Oct;53(10):2467-72. Unique Identifier : AIDSLINE MED/96021739; Eguchi K; Mizokami A; Katamine S; First Department of Internal Medicine, Nagasaki University School; of Medicine.; The HTLV-I seroprevalence rate among the patients with Sjogren s syndrome (SjS, 23.0%) was significantly higher than that among blood donors (3.4%). The age-adjusted summary odds ratio of HTLV-I infection among SjS patients as compared with blood donors was 3.1. The etiologic fraction, i.e., the proportion of SjS in t
[Expression of sequences homologous to HTLV-I pXIV gene in the labial salivary glands of Japanese patients with Sjogren's syndrome and pathogenesis]: Nippon Rinsho. 1995 Oct;53(10):2473-8. Unique Identifier : AIDSLINE MED/96021740; Yonaha-Nagato F; Sumida T; Division of Dermatology, Sakura Hospital, Toho University School; of Medicine.; To address the question of whether the human T cell leukemia virus type I (HTLV-I) gene is associated with the etiology of Sjogren s syndrome (SS), RNA expression of HTLV-I gag, pol, env, and tax genes in labial salivary glands (LSGs) from SS patients who were seronegative for antibodies to HTLV-I was examined using R
The story behind the creation of the Michigan AIDS Fund.: Mich Med. 1995 Nov;94(11):11-3. Unique Identifier : AIDSLINE MED/96108113; Strumwasser I
Thyroid therapy in HIV-infected patients.: Med Hypotheses. 1995 Aug;45(2):121-4. Unique Identifier : AIDSLINE MED/96104076; Derry DM; Ten HIV-positive patients were given thyroid hormone in pharmacological doses. Two patients that had CD4 counts of 200 or higher responded well with gain in weight, energy, endurance and well-being within 6 months. During the same period, their CD4 counts rose to within normal limits and remained there. One patient ha
Leukocyte adhesion molecules as a cofactor in AIDS: basic science and pilot study.: Med Hypotheses. 1995 Aug;45(2):164-8. Unique Identifier : AIDSLINE MED/96104083; Allen AD; Hart DN; Hechinger MK; Slattery MJ; Chesson CV 2nd; Vidikan P; CytoDyn of New Mexico, Inc., Santa Fe 87501, USA.; It is well known that the AIDS pandemic is a consequence of pandemic HIV infection. However, Koch s postulates are not satisfied for two reasons: 1) AIDS cannot be experimentally produced in animals susceptible to HIV infection and 2) some people have AIDS (idiopathic CD4+ T lymphocytopenia) in the absence of HIV infe
Trypsin inhibition: a potential cause of cobalamin deficiency common to the pathogenesis of Alzheimer-type dementia and AIDS dementia complex?: Med Hypotheses. 1995 Aug;45(2):200-4. Unique Identifier : AIDSLINE MED/96104087; McCaddon A; Regland B; Fear CF; Department of Clinical Neuroscience, Molndal Hospital of; Goteborg, Sweden.; There is increasing evidence for an association between Alzheimer-type dementia (AD) and nutritionally independent cobalamin deficiency. Furthermore, low serum cobalamin values occur in a kindred with familial Alzheimer s disease (FAD) and histopathological confirmation of AD neuro
Massive gastrointestinal hemorrhage from AIDS-related Kaposi's sarcoma confined to the small bowel managed with radiation.: Med Pediatr Oncol. 1996 Feb;26(2):135-8. Unique Identifier : AIDSLINE MED/96121152; Neville CR; Peddada AV; Smith D; Kagan AR; Frost DB; Sadoff L; Department of Radiation Oncology, Southern California Permanente; Medical Group, Los Angeles, USA.; A > 50% incidence of Kaposi s sarcoma (KS) of the gastrointestinal tract has been seen in acquired immunodeficiency syndrome (AIDS) patients with cutaneous KS. Although gastrointestinal Kaposi s sarcoma (GIKS) is usually asymptomatic, hemorrhages from the oral cavity, esophagus, stomach, and large bowel have occurred
[Clinical aspects of immunoneuroendocrine alterations in HIV infection]: Minerva Endocrinol. 1995 Jun;20(2):113-26. Unique Identifier : AIDSLINE MED/96104477; Rondanelli M; Minoli L; A number of studies confirm that any human tissue can be targeted by HIV, and also the endocrine system is involved during HIV infection. No endocrine adenus is saved by the assault of the opportunistic pathogens that overrun the organism unprotected due to the severe and progressive immune deficits induced by the HIV
Attitude adjustment. A complacent public tunes out the AIDS epidemic.: Minn Med. 1995 Nov;78(11):10-4, 64-5. Unique Identifier : AIDSLINE MED/96102647; Feldman MK
HIV: an endemic health problem in Minnesota.: Minn Med. 1995 Nov;78(11):15-6. Unique Identifier : AIDSLINE MED/96102648; Henry K; HIV/AIDS Clinic and Programs, Health Partners St. Paul-Ramsey; Medical Center, USA.
Management of HIV infection. A 1995-96 overview for the clinician.: Minn Med. 1995 Nov;78(11):17-24. Unique Identifier : AIDSLINE MED/96102649; Henry K; AIDS Clinic and Programs, Health-Partners St. Paul-Ramsey Medical; Center, USA.; Although the challenges of HIV/AIDS care may seem overwhelming, we are better able than ever to positively affect the course of HIV for each individual patient. Treatment goals involve three areas: 1) Antiretroviral drugs aimed at retarding the rate of HIV replication, thus reducing the rate of damage to the immune sy
Directions in HIV/AIDS research. A Minnesota perspective.: Minn Med. 1995 Nov;78(11):26-34. Unique Identifier : AIDSLINE MED/96102650; Henry K; Melroe H; Nelson R; HIV/AIDS Clinic and Programs, Health-Partners St. Paul-Ramsey; Medical Center, USA.; Clinical studies involving HIV therapeutics are becoming ever more challenging because of the changing epidemiology of HIV infection, the rapid evolution of standard clinical practice, and a more difficult economic environment for research. Recent studies relating to HIV pathogenesis have provided novel insights into
HIV infection in women and children.: Minn Med. 1995 Nov;78(11):35-9. Unique Identifier : AIDSLINE MED/96102651; Schwebke KE; Hoyt LG; HIV/AIDS Clinic and Programs, Health Partners St. Paul-Ramsey; Medical Center, USA.; AIDS is increasing more rapidly among women than men and has become the fourth-leading cause of death for women between the ages of 25 and 44 years in the United States . This changing epidemiological trend accounts for the increase in pediatric cases of HIV infection. This article summ
Needlestick/sharps injuries and HIV exposure among health care workers. National estimates based on a survey of U.S. hospitals.: Minn Med. 1995 Nov;78(11):41-4. Unique Identifier : AIDSLINE MED/96102652; Henry K; Campbell S; HIV/AIDS Clinic and Programs, Health-Partners St. Paul-Ramsey; Medical Center, USA.; Exposure to HIV in the workplace is a major concern for health care workers. The greatest risk for bloodborne pathogen transmission is associated with percutaneous injuries involving hollow-bore needles contaminated with patient blood. Limited data are available about how many sharps injuries (SIs) and needlesticks (N
U.S. prisoners' access to experimental HIV therapies.: Minn Med. 1995 Nov;78(11):45-8. Unique Identifier : AIDSLINE MED/96102653; Collins A; Baumgartner D; Henry K; Minnesota Department of Corrections, USA.; PURPOSE: To examine Department of Corrections (DOC) policies prohibiting prisoner participation in research studies and to assess the variables associated with state policies and practices relating to access by inmates in U.S. prisons to HIV-related clinical studies and experimental therapies. METHODS: A telephone sur
AIDS. Public perceptions obscure medical discourse [editorial]: Minn Med. 1995 Nov;78(11):5. Unique Identifier : AIDSLINE MED/96102645; Meyer CR
More than medicine: caring for the AIDS patient.: Minn Med. 1995 Nov;78(11):6-7, 62-3. Unique Identifier : AIDSLINE MED/96102646; Simpson M; Schut R
Case-control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV-infected blood--France, United Kingdom, and United States, January 1988-August 1994.: MMWR Morb Mortal Wkly Rep. 1995 Dec 22;44(50):929-33. Unique Identifier : AIDSLINE MED/96127950; Health-care workers (HCWs) are potentially at risk for human immunodeficiency virus (HIV) infection through occupational exposures to blood. Although prospective studies indicate that the estimated risk for HIV infection after a percutaneous exposure to HIV-infected blood is approximately 0.3% (1,2), factors that infl
Surveillance of tuberculosis and AIDS co-morbidity--Florida, 1981-1993.: MMWR Morb Mortal Wkly Rep. 1996 Jan 19;45(2):38-41. Unique Identifier : AIDSLINE MED/96136181; Because immunosuppression induced by human immunodeficiency virus (HIV) infection increases the likelihood that latent tuberculosis (TB) infection will become active in HIV-infected persons (1,2), in 1987, extrapulmonary or disseminated TB was added to the acquired immunodeficiency syndrome (AIDS) surveillance case de
Phialophora verrucosa infection in an AIDS patient.: Mycoses. 1995 May-Jun;38(5-6):215-8. Unique Identifier : AIDSLINE MED/96102662; Duggan JM; Wolf MD; Kauffman CA; Department of Internal Medicine, Veterans Affairs Medical Center,; University of Michigan Medical School, Ann Arbor 48105, USA.; Phialophora verrucosa is one of several pathogenic dematiaceous fungi associated with chromomycosis and occasionally phaeohyphomycosis. Infection appears to be increasing in frequency in both immunocompromised and presumably healthy patients. Medical therapy is often difficult, and a wide variety of antifungal agents
Race, sex, drug use, and human immunodeficiency virus disease [letter; comment]: N Engl J Med. 1996 Jan 11;334(2):123; discussion 123-4. Unique Identifier : AIDSLINE MED/96127971; Hogg RS; Craib K; Montaner JS; Schechter MT
Race, sex, drug use, and human immunodeficiency virus disease [letter; comment]: N Engl J Med. 1996 Jan 11;334(2):123-4. Unique Identifier : AIDSLINE MED/96127972; Turner BJ; Markson LE; Fanning TR
Bacterial pneumonia in HIV [letter; comment]: N Engl J Med. 1996 Jan 18;334(3):195. Unique Identifier : AIDSLINE MED/96127999; Cohen JI
Multidrug-resistant tuberculosis [letter; comment]: N Engl J Med. 1996 Jan 25;334(4):267; discussion 268-9. Unique Identifier : AIDSLINE MED/96132567; Iseman MD; Goble M
Body-cavity-based lymphoma in an HIV-seronegative patient without Kaposi's sarcoma-associated herpesvirus-like DNA sequences [letter; comment]: N Engl J Med. 1996 Jan 25;334(4):272-3. Unique Identifier : AIDSLINE MED/96132575; Hermine O; Michel M; Buzyn-Veil A; Gessain A
Antisense-oligonucleotide therapy.: N Engl J Med. 1996 Feb 1;334(5):316-8. Unique Identifier : AIDSLINE MED/96133746; Askari FK; McDonnell WM; Department of Internal Medicine, University of Michigan School of; Medicine, Ann Arbor, USA.
Adult counseling for sexually transmitted diseases and HIV infection. U.S. Public Health Service.: Nurse Pract. 1995 Oct;20(10):76-9. Unique Identifier : AIDSLINE MED/96117258
Advance directives: matters of life and death [news]: Nurse Pract. 1995 Oct;20(10):88-90. Unique Identifier : AIDSLINE MED/96117259; Klaus BD
Acquired immunodeficiency syndrome (AIDS) and the eye.: Ophthalmic Physiol Opt. 1995 Sep;15 Suppl 2:S42-8. Unique Identifier : AIDSLINE MED/96103707; Armstrong RA; Department of Vision Sciences, Aston University, Birmingham, UK.
Repeatedly positive human immunodeficiency virus type 1 DNA polymerase chain reaction in human immunodeficiency virus-exposed seroreverting infants.: Pediatr Infect Dis J. 1995 Aug;14(8):658-62. Unique Identifier : AIDSLINE MED/96016429; Bakshi SS; Tetali S; Abrams EJ; Paul MO; Pahwa SG; Department of Pediatrics, North Shore University Hospital,; Cornell University Medical College, Manhasset, NY, USA.; Three human immunodeficiency virus type 1 (HIV-1)-exposed children who had repeatedly positive DNA polymerase chain reaction (PCR) tests for HIV in > or = 5 samples before seroreversion to HIV-negative status are reported. The children belong to a cohort of 210 infants who were born to HIV-infected mothers and were te
Weight, height and human immunodeficiency virus infection in young children of infected mothers. The European Collaborative Study.: Pediatr Infect Dis J. 1995 Aug;14(8):685-90. Unique Identifier : AIDSLINE MED/96016434; In a longitudinal study of weight and height over the first 4 years of life, 123 human immunodeficiency virus (HIV)-infected and 654 uninfected children of similar social background were compared. By 3 months of age there was a 400-g (8.0%) difference in weight and an 0.8-cm (1.3%) difference in height between infecte
Polymerase chain reaction is more sensitive than standard cytologic stains in detecting Pneumocystis carinii in bronchoalveolar lavages from human immunodeficiency virus type 1-infected infants and children with pneumonia.: Pediatr Infect Dis J. 1995 Aug;14(8):714-6. Unique Identifier : AIDSLINE MED/96016442; Leibovitz E; Pollack H; Rigaud M; Kaul A; Persaud D; Gallo L; Papellas J; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical Center, NY,; USA.
Sinusitis caused by Mycobacterium avium-intracellulare in a patient with human immunodeficiency virus [letter]: Pediatr Infect Dis J. 1995 Aug;14(8):726-7. Unique Identifier : AIDSLINE MED/96016451; Sussman SJ
Brain-emitted event-related potentials recorded during rapid decision-making may be useful in monitoring the neuropathogenesis of the human immunodeficiency virus (HIV).: Percept Mot Skills. 1995 Aug;81(1):209-10. Unique Identifier : AIDSLINE MED/96093292; Linnville SE; Naval Health Research Center, San Diego, CA, USA.; Event-related potentials recorded from HIV-infected patients while they detected oddball targets during rapid delivery of dual sequences of tones showed the complete absence of the late, 300-msec., positive (P300) component, suggesting an alteration in the neuronal activity underlying cognitive processing.
Interaction between a Fab fragment against gp41 of human immunodeficiency virus 1 and its peptide epitope: characterization using a peptide epitope library and molecular modeling.: Protein Eng. 1995 May;8(5):471-9. Unique Identifier : AIDSLINE MED/96016641; Stigler RD; Ruker F; Katinger D; Elliott G; Hohne W; Henklein P; Ho JX; Keeling K; Carter DC; Nugel E; et al; Institut fur Medizinische Immunologie, Universitatsklinikum; Charite, Humboldt-Universitat zu Berlin, Germany.; The molecular interaction of the Fab fragment of the human monoclonal antibody 3D6, directed against the transmembrane protein gp41 of human immunodeficiency virus (HIV) 1, with its peptide epitope is characterized by a panel of overlapping peptides, a peptide epitope library and molecular modeling techniques. The seq
Leprosy in five human immunodeficiency virus-infected patients.: Mod Pathol. 1995 Aug;8(6):662-4. Unique Identifier : AIDSLINE MED/96020620; Moran CA; Nelson AM; Tuur SM; Luengu M; Fonseca L; Meyers WM; Department of Infectious and Parasitic Disease Pathology, Armed; Forces Institute of Pathology, Washington, DC, USA.; We present five cases of leprosy in five human immunodeficiency virus-positive individuals. The patients were five men between the ages of 18 and 45 years. The five patients presented with skin lesions; three patients with hypopigmented skin lesions, one with skin macules and a history of leprosy, and one with papular
[Chronic rheumatoid arthritis model mice transgenic for the HTLV-I tax gene]: Tanpakushitsu Kakusan Koso. 1995 Oct;40(14):2074-82. Unique Identifier : AIDSLINE MED/96056985; Iwakura Y; Laboratory Animal Research Center, University of Tokyo, Japan.
[Serum hepatitis B markers: atypical patterns detected at the Hospital Insular de Gran Canaria]: Rev Clin Esp. 1995 Oct;195(10):674-7. Unique Identifier : AIDSLINE MED/96103232; Santana OE; Frances A; Sierra A; Hernandez J; Martin-Sanchez AM; Servicio de Microbiologia, Hospital Insular de Gran Canaria,; Facultad de Ciencias de la Salud, Universidad de Las Palmas de; Gran Canaria.; Two atypical serological markers of hepatitis B virus (HBV) infection were detected in 19 patients during a 18-month period study. Pattern 1 (10 patients) was consistent with HBV-2 infection. Reactivity of HbsAG was confirmed by neutralization tests; the absence of other markers was also verified, included anti-HBcIgM
[Strategies for the prevention of human immunodeficiency virus infection]: Rev Clin Esp. 1995 Oct;195(10):701-7. Unique Identifier : AIDSLINE MED/96103237; Soriano V; Leal M; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[The rapid and slow progression of HIV infection]: Rev Clin Esp. 1995 Oct;195(10):708-14. Unique Identifier : AIDSLINE MED/96103238; Soriano V; Martin R; del Romero J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
Activation of bronchoalveolar lavage T lymphocytes and clinical, functional and radiological features in sarcoidosis.: Sarcoidosis. 1995 Sep;12(2):135-9. Unique Identifier : AIDSLINE MED/96105964; Schoenfeld N; Schmitt M; Remy N; Ellensohn P; Loddenkemper R; Wahn U; Lungenklinik Heckeshorn, Kinderklinik KAVH; (Humboldt-Universitat), Berlin, Germany.; Previous studies on the relationship between activated BAL T lymphocytes and clinical features in sarcoidosis revealed controversial results. We determined lavage lymphocytes, T lymphocytes, activated T lymphocytes, helper, suppressor and natural killer cells in 50 patients with pulmonary sarcoidosis and compared the
Granuloma formation signifies a Th1 cell profile [editorial]: Sarcoidosis. 1995 Sep;12(2):95-7. Unique Identifier : AIDSLINE MED/96105958; James DG
Difference in clinical implications of CD4 counts among HIV-infected homosexual men and injection drug using men and women.: Stat Med. 1995 Sep 15;14(17):1889-900. Unique Identifier : AIDSLINE MED/96090736; Paik MC; Begg MD; el-Sadr W; Gorman J; Stien Z; Division of Biostatistics, School of Public Health, Columbia; University, NY, NY, 10032, USA.; While the relationship between CD4 counts and clinical symptoms is well established among homosexual men, the same is not true for injection drug using men and women (IDUM and IDUW). In this paper we investigate whether CD4 counts have the same clinical implications for IDUM and IDUW as for homosexual men. We estimate
[The eye and HIV (editorial)]: Schweiz Rundsch Med Prax. 1995 Nov 28;84(48):1403-4. Unique Identifier : AIDSLINE MED/96097483; Bernauer W
Prevalence and risk factors of HIV-1 infection in three parishes in western Uganda.: Trop Med Parasitol. 1995 Sep;46(3):141-6. Unique Identifier : AIDSLINE MED/96105991; Kipp W; Kabwa P; Verbeck A; Fischer P; Eggert P; Buttner DW; Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), Fort; Portal.; A population-based serosurvey was conducted to determine the HIV-1 prevalence and to evaluate various risk factors in three parishes in western Uganda . Adults over 14 years were examined in all 13 villages of Kigoyera parish far from Fort Portal, in two villages of Kyamukoka parish
Detection of antibodies to HIV-1 gp41- and HLA class II antigen-derived peptides in SLE patients.: Scand J Rheumatol. 1995;24(5):288-92. Unique Identifier : AIDSLINE MED/96106379; Koshino K; Tokano Y; Hishikawa T; Sekigawa I; Takasaki Y; Hashimoto H; Department of Medicine, Juntendo University School of Medicine,; Tokyo, Japan.; A role for viruses in the pathogenesis of human autoimmune diseases has long been suspected but has not yet been proven. Highly conserved homologous regions has been reported in the carboxy terminus of human immunodeficiency virus (HIV)-1 gp41 (amino acids 838-844) and the amino-terminal of the beta chain of all human
AIDS concerns [letter]: Sci Am. 1996 Jan;274(1):10. Unique Identifier : AIDSLINE MED/96106204; Blott KW
The immunopathology of unilateral vasectomy in the ram.: Vet Immunol Immunopathol. 1995 Jul;47(1-2):123-33. Unique Identifier : AIDSLINE MED/96138917; Jessop TS; Ladds PW; Department of Biomedical and Tropical Veterinary Sciences, James; Cook University of North Queensland, Townsville, Australia.; This study investigated the relationship between the local (spermatic granuloma) and systemic events after unilateral vasectomy in six rams. Spermatic microgranulomas were first observed at 4 weeks post vasectomy (PV), at which time lymphocytes, chiefly CD4+ (helper/inducer) cells, were incorporated into the periphery
Analysis of feline dual lymphocyte populations observed by flow cytometry.: Vet Immunol Immunopathol. 1995 Sep;48(1-2):11-25. Unique Identifier : AIDSLINE MED/96106999; Walker C; Bao S; Canfield PJ; Department of Veterinary Pathology, University of Sydney, N.S.W.,; Australia.; Two discrete lymphocyte populations were observed commonly on flow cytometric analysis (FCM) of feline lymphocyte subsets. The identity of these populations as small and large lymphocytes was established by correlating data from FCM with that from peripheral blood films. Dual lymphocyte populations were more likely to
Up-regulation of IL-2 receptor alpha and MHC class II expression on lymphocyte subpopulations from bovine leukemia virus infected lymphocytotic cows.: Vet Immunol Immunopathol. 1995 Sep;48(1-2):65-76. Unique Identifier : AIDSLINE MED/96107003; Stone DM; Hof AJ; Davis WC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99164-7040, USA.; Infection with bovine leukemia virus (BLV) leads to a persistent lymphocytosis (PL) characterized by a marked increase in circulating B lymphocytes that express the orthologue of CD5. To gain insight into the factors accounting for lymphocytosis, experiments were conducted to determine the functional activation status
Effect of bovine leukemia virus infection on bovine peripheral blood monocyte responsiveness to lipopolysaccharide stimulation in vitro.: Vet Immunol Immunopathol. 1995 Sep;48(1-2):77-88. Unique Identifier : AIDSLINE MED/96107004; Werling D; Sileghem M; Lutz H; Langhans W; Institute for Animal Sciences, Swiss Federal Institute of; Technology, ETH-Zentrum, Zurich, Switzerland.; The effects of bovine leukemia virus (BLV) infection on cytokine activity of bovine monocytes stimulated with Escherichia coli lipopolysaccharide (LPS) were examined. Compared to supernatants of LPS-stimulated monocytes from BLV-negative cows, supernatants from BLV-positive cows contained about four times more interle
Neurology of human immunodeficiency virus infection--past, present, and future.: West J Med. 1995 Nov;163(5):470-1. Unique Identifier : AIDSLINE MED/96102744; Jay C
Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein.: Virus Res. 1995 Aug;37(3):209-20. Unique Identifier : AIDSLINE MED/96136654; Ray RB; Lagging LM; Meyer K; Steele R; Ray R; Division of Infectious Disease and Immunology, Saint Louis; University Health Sciences Center, MO 63110-0250, USA.; The genomic region encoding the hepatitis C virus (HCV) core protein was cloned into a mammalian expression vector to study its role on the transcriptional regulation of cellular proto-oncogene and viral promoters. Using a transient transfection assay in human hepatocellular carcinoma (HepG2) cells, we demonstrate tha
[Interferon-alpha controls HPV infection in cervix epithelium]: Zentralbl Gynakol. 1995;117(11):566-77. Unique Identifier : AIDSLINE MED/96098816; Labeit D; Labeit S; Berger M; Gallati H; Rosenberg R; Friese K; Universitatsfrauenklinik Mannheim.; Decreased immune response is necessary for a prolonged HPV-infection and allows HPV to be virulent as an oncogene. This study shows that HPV-infection in cervical epithelium is determined by the immune system and IFN-alpha can be shown to be a prognostic parameter for the HPV-infection. The cytokines (IFN-alpha, IFN-g
Sexually transmitted diseases in Swedish women with experience of casual sex with men of foreign nationalities within Sweden.: Acta Obstet Gynecol Scand. 1995 Nov;74(10):794-8. Unique Identifier : AIDSLINE MED/96127830; Arvidson M; Hellberg D; Mardh PA; Institute of Clinical Bacteriology, Uppsala University, Sweden.; BACKGROUND. This study was performed in women who had attended the clinic for contraceptive advice to determine whether a history of casual sex with a foreign male, previously unknown to them (SFM) in their home country ( Sweden ), constituted an increased risk for acquiring sexually
Detection of immunodeficiencies and persistent infections by urinary neopterin measurement.: Acta Paediatr Jpn. 1995 Oct;37(5):575-8. Unique Identifier : AIDSLINE MED/96094004; Hara T; Matsuo M; Tasaki R; Miyazaki S; Bamba M; Division of Child Neurology, Tottori University School of; Medicine, Japan.; We evaluated the clinical significance of measurement of urinary neopterin levels in primary immunodeficiencies and persistent infections exclusively at afebrile or asymptomatic periods. Despite the examinations at afebrile or asymptomatic periods, urinary neopterin levels were elevated in some patients with primary i
Long-term sequential changes of antibody to p40tax in HTLV-I carrier mothers and children.: Acta Paediatr Jpn. 1995 Oct;37(5):651-3. Unique Identifier : AIDSLINE MED/96094022; Kusuhara K; Ueda K; Tokugawa K; Miyazaki C; Okada K; Sawada T; Department of Pediatrics, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.; Antibody to p40tax (anti-p40tax) in serum specimens obtained sequentially from a human T cell lymphotropic virus type I carrier population of mothers and children were assayed. The prevalences of anti-p40tax at the initial sampling were 88% (7/8) in children and 55% (16/29) in mothers. Two of the seven positive childr
A comparative study of PCR product detection and quantitation by electro-chemiluminescence and fluorescence.: J Biolumin Chemilumin. 1995 Jul-Aug;10(4):239-45. Unique Identifier : AIDSLINE MED/96084083; Yu H; Bruno JG; Cheng TC; Calomiris JJ; Goode MT; Gatto-Menking DL; Optech Corporation, San Antonio, TX 78229, USA.; Amplification and detection of target DNA sequences are made possible in a polymerase chain reaction (PCR) by using a mixture of biotinylated and ruthenium(II) trisbipyridal (Ru(bpy)3(2+))-end-labelled primers. In this way, biotin for capture and Ru(bpy)3(2+) for detection are directly incorporated into the PCR produc
[The use of serological tests for detecting HIV infection in general clinical consultations and hospital consultations]: Acta Med Port. 1995 Oct;8(10):543-52. Unique Identifier : AIDSLINE MED/96120094; Maria VA; Pimpao MV; Carvalho ML; Sousa AE; Lucas MM; Victorino RM; Centro de Saude do Cacem, ARS de Lisboa e Vale do Tejo.; AIMS: To determine the number and type of HIV tests requested in general practice (GP) and in hospital outpatient clinics, to identify principle risk behaviors, to determine the percentage of HIV positive tests and to identify possible factors associated with the request of HIV tests. METHODS: Cross-sectional, analyti
[Tuberculosis in Portugal]: Acta Med Port. 1995 Oct;8(10):559-65. Unique Identifier : AIDSLINE MED/96120096; Antunes M de L; Nucleo de Tuberculose, Direccao Geral de Saude, Lisboa.; There is a general downward trend of most epidemiological indices for TB, except for mortality. Incidence and prevalence rates were, for the first time ever, situated below 50 cases/100,000 inhabitants and smear-positive cases below 25/100,000. TB occurs mostly in the large, coastal cities, Lisboa and Oporto having 50
Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin.: Acta Trop. 1995 Aug;59(4):271-7. Unique Identifier : AIDSLINE MED/96087257; Rodier MH; Berthonneau J; Bourgoin A; Giraudeau G; Agius G; Burucoa C; Hekpazo A; Jacquemin JL; Laboratoire de Parasitologie et Epidemiologie Tropicale, CHU La; Miletrie, Poitiers, France.; Seroprevalences for toxoplasmosis, malaria, rubella, cytomegalovirus , HIV and treponemal infections were evaluated among 211 pregnant women residing in the Cotonou area, Republic of Benin . One hundred and thirteen women (53.6%) had toxoplasma ant
Re: The spectrum of medical conditions and symptoms before acquired immunodeficiency syndrome in homosexual and bisexual men infected with the human immunodeficiency virus [letter; comment]: Am J Epidemiol. 1996 Jan 1;143(1):102-3. Unique Identifier : AIDSLINE MED/96129948; Salman MD; Hutchison JM; Smith M
T-lymphocyte subsets and prolonged diarrhea in young children from Guinea-Bissau.: Am J Epidemiol. 1996 Jan 1;143(1):79-84. Unique Identifier : AIDSLINE MED/96129944; Molbak K; Lisse IM; Aaby P; Epidemiology Research Unit, Danish Epidemiology Science Centre,; Statens Seruminstitut, Copenhagen, Denmark.; In a community-based prospective study of 380 children conducted between 1987 and 1990, the rate of diarrhea was significantly associated with percentage of CD8 T-lymphocytes and the CD4:CD8 ratio. After adjustment for age and previous diarrhea, the relative incidence of diarrhea with a duration of > or = 7 days was 2
A general method to recondition and reuse BIAcore sensor chips fouled with covalently immobilized protein/peptide.: Anal Biochem. 1995 Jul 20;229(1):112-8. Unique Identifier : AIDSLINE MED/96140938; Chatelier RC; Gengenbach TR; Griesser HJ; Brigham-Burke M; O'Shannessy DJ; Division of Chemicals and Polymers, CSIRO, Clayton, Victoria,; Australia.; Of significance in the routine use of BIAcore is the cost of the sensor chips. This is particularly evident during the phase of method development of an assay where it is not unusual to expend several chips in a day in attempts to optimize immobilization conditions for a novel peptide or protein. In addition, it is ac
Automation of a high-performance liquid chromatography-based enzyme assay: evaluation of inhibition constants for human immunodeficiency virus-1 protease inhibitors.: Anal Biochem. 1995 Jul 20;229(1):48-53. Unique Identifier : AIDSLINE MED/96140929; Pazhanisamy S; Stuver CM; Livingston DJ; Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts; 02139, USA.; Enzyme-based assays are commonly employed in clinical and pharmaceutical laboratories to aid in quantitation of organic substances. Many enzyme assays are tedious, requiring the addition of reagents at multiple time intervals. The HPLC-based analysis of reaction products requires an additional step of vialing the samp
The 1990 Florida Dental Investigation: is the case really closed? [see comments]: Ann Intern Med. 1996 Jan 15;124(2):250-4. Unique Identifier : AIDSLINE MED/96124767; Barr S; In 1994, a magazine article, a newspaper article, and a segment of the television newsmagazine 60 Minutes presented information that cast doubt on the Centers for Disease Control and Prevention s conclusion that a dentist in Florida had infected six of his patients with the human immunodeficiency virus (HIV). These re
The 1990 Florida Dental Investigation: theory and fact [comment]: Ann Intern Med. 1996 Jan 15;124(2):255-6. Unique Identifier : AIDSLINE MED/96124768; Brown D; Washington Post, Washington, DC 20071, USA.; Controversy remains about the Centers for Disease Control and Prevention s (CDC) conclusion that a dentist in Florida transmitted human immunodeficiency virus to six of his patients in the late 1980s. The most vocal doubt has come from journalists affiliated with the television program 60 Minutes. Although unanswered
Infection risks to patients from HIV-infected health care workers [letter]: Ann Intern Med. 1996 Jan 15;124(2):277-8. Unique Identifier : AIDSLINE MED/96124781; Collignon P
A nurse's right to refuse a patient care assignment.: AORN J. 1995 Sep;62(3):412-4, 416, 418. Unique Identifier : AIDSLINE MED/96090648; Kuhn JE; St Luke's Hospital, San Francisco, USA.; Ethics is a set of moral principles or values--a guiding philosophy for behavior. Ethical dilemmas in the health care setting occur daily. Perioperative nurse managers need to consider basic ethical principles when resolving these dilemmas, and they must keep in mind that solutions need to serve the best interests of
Emotional distress suits brought after exposure to HIV.: AORN J. 1995 Sep;62(3):442-4. Unique Identifier : AIDSLINE MED/96090652; Murphy EK; University of Wisconsin-Milwaukee, USA.
Training traditional birth attendants in Nigeria--the pictorial method.: World Health Forum. 1995;16(4):409-13. Unique Identifier : AIDSLINE MED/96119122; Matthews MK; Walley RL; Ward A; Akpaidem M; Williams P; Umoh A; School of Nursing, Memorial University, St John's, Newfoundland,; Canada.; High maternal mortality and morbidity rates are a challenge for all involved in the care of mothers and babies. One response takes the form of an educational programme led by professional midwives to teach traditional birth attendants to recognize risk conditions and improve their care of mothers and babies. Such a pr
Serodiagnosis of Helicobacter pylori infection in patients with human immunodeficiency virus infection.: APMIS. 1995 Oct;103(10):689-92. Unique Identifier : AIDSLINE MED/96125696; Nielsen H; Andersen LP; Department of Infectious Diseases, Hvidovre University Hospital,; Copenhagen, Denmark.; In contrast to the established role of Helicobacter pylori gastritis in gastritis and duodenal ulcer in general, conflicting results have been reported in patients with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome. The seroprevalence during early HIV infection is unknown. We
The European Collaborative Study: clinical and immunological characteristics of HIV 1-infected pregnant women.: Br J Obstet Gynaecol. 1995 Nov;102(11):869-75. Unique Identifier : AIDSLINE MED/96137871; Thorne C; Newell ML; Dunn D; Peckham C; Epidemiology and Biostatistics Unit, Institute of Child Health,; London, UK.; OBJECTIVE: To describe the changing clinical and immunological characteristics and timing of diagnosis of HIV-infected pregnant women enrolled in the European Collaborative Study. DESIGN: A prospective study of the mothers of children enrolled in the European Collaborative Study on children born to HIV-infected women.
HTLV-I associated uveitis in central Japan.: Br J Ophthalmol. 1995 Nov;79(11):1018-20. Unique Identifier : AIDSLINE MED/96137905; Goto K; Saeki K; Kurita M; Ohno S; Division of Ophthalmology, Odawara Municipal Hospital, Japan.; AIMS/BACKGROUND--Recently HTLV-I has been shown to cause a kind of endogenous uveitis in south west Japan , where HTLV-I infection is highly endemic. To investigate further the association of HTLV-I infection with the incidence of this uveitis, HTLV-I seroprevalence in central Japan,
[Medical care of AIDS patients by hospitals in Tokyo]: Nippon Koshu Eisei Zasshi. 1995 Sep;42(9):799-807. Unique Identifier : AIDSLINE MED/96092223; Okajima F; Araki S; Shiokawa Y; Ashizawa M; Minamitani M; Murata K; Sata F; Maeda H; Ishii A; Department of Public Health, Faculty of Medicine, University of; Tokyo.; An anonymous questionnaire survey was performed in 1991 in all 749 hospitals in Tokyo, by the Tokyo Metropolitan Government s Acquired Immunodeficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) Infection Research Team, to collect information relating to hospital services for persons with AIDS or HIV infec
[Trends and analysis of HIV and sexually transmitted disease infection in foreign commercial sex workers in Japan]: Nippon Koshu Eisei Zasshi. 1995 Sep;42(9):808-14. Unique Identifier : AIDSLINE MED/96092224; Uchino H
Suramin blocks binding of interleukin-4 to its receptors on human tumor cells and interleukin-4-induced mitogenic response.: Oncol Res. 1995;7(5):227-35. Unique Identifier : AIDSLINE MED/96034539; Leland P; Obiri N; Aggarwal BB; Puri RK; Laboratory of Molecular Tumor Biology, FDA, Bethesda, MD; 20892-4555, USA.; Suramin, a polysulphonated naphthylurea, has antiproliferative, anticancer, and anti-HIV activities and has been shown to prevent binding of a variety of growth factors to their respective receptors. In the current study we have investigated the effects of suramin on binding of interleukin-4 (IL-4) to its receptors an
What is new in fixed drug eruption? [editorial; comment]: Dermatology. 1995;191(3):185-7. Unique Identifier : AIDSLINE MED/96119859; Shiohara T
Follicular accentuation of leukocytoclastic vasculitis in an HIV-infected patient [letter]: Dermatology. 1995;191(3):268-9. Unique Identifier : AIDSLINE MED/96119878; Garcia-Doval I; Sanchez-Aguilar D; Peteiro C; Toribio J
Requirements for optimal expression of secreted and nonsecreted recombinant proteins in vaccinia virus systems.: Protein Expr Purif. 1995 Oct;6(5):559-69. Unique Identifier : AIDSLINE MED/96106929; Pfleiderer M; Falkner FG; Dorner F; Immuno AG Biomedical Research Center, Orth/Donau, Austria.; Selection of an optimal promoter is necessary for efficient expression of foreign genes with vaccinia virus. Since a variety of powerful (homologous) vaccinia virus promoters and foreign (heterologous) promoter systems have been described for use in vaccinia, we have addressed the question of whether a general rule ex
Combination chemotherapy (RCM protocol: response-oriented cyclic multidrug protocol) for the acute or lymphoma type adult T-cell leukemia.: Leuk Lymphoma. 1995 Jul;18(3-4):317-23. Unique Identifier : AIDSLINE MED/96077739; Uozumi K; Hanada S; Ohno N; Ishitsuka K; Shimotakahara S; Otsuka M; Chyuman Y; Nakahara K; Takeshita T; Kuwazuru Y; et al; Second Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.; 43 patients with the acute or lymphoma type ATL were treated with the new combination chemotherapy (RCM protocol: response-oriented cyclic multidrug protocol) between January 1989 and December 1991. Complete response (CR) and partial response (PR) were achieved in 20.9% and 65.1% of all treated patients respectively.
Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors: total energy of complexation as a predictor of drug placement and activity.: Protein Sci. 1995 Oct;4(10):2203-22. Unique Identifier : AIDSLINE MED/96117671; Kroeger Smith MB; Rouzer CA; Taneyhill LA; Smith NA; Hughes SH; Boyer PL; Janssen PA; Moereels H; Koymans L; Arnold E; et al; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Maryland 21702, USA.; Computer modeling studies have been carried out on three nonnucleoside inhibitors complexed with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), using crystal coordinate data from a subset of the protein surrounding the binding pocket region. Results from the minimizations of solvated complexes
[Modification of the functional activity of neutrophils by a synthetic peptide from the V3-loop of the HIV envelope protein gp120]: Dokl Akad Nauk. 1995 Sep;344(1):133-5. Unique Identifier : AIDSLINE MED/96098396; Zemskov VM; Subbotin SM; Volkov IuT; Kiriukhin AIu; Andreev SM; Nekhaev IV; Umenko EN; Petrukhina AO; Vafina MG; Molodtsov NV
Are there new perinatal treatment recommendations for decreasing vertical transmission of human immunodeficiency virus (HIV)?: AWHONN Voice. 1995 Oct-Nov;3(9):10. Unique Identifier : AIDSLINE MED/96138665; Jones MM
Introduction: perspectives in HIV care: a view from the front lines.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):173-7. Unique Identifier : AIDSLINE MED/96029586; Stein GL; HIV Professional Development Project, New York Academy of; Medicine, NY 10029, USA.
A journey through the epidemic.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):178-86. Unique Identifier : AIDSLINE MED/96149135; Friedland GH; AIDS Program, Yale University School of Medicine, New Haven, CT; 06501, USA.
A view from the front lines of bioethics.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):187-201. Unique Identifier : AIDSLINE MED/96029587; Levine C; Orphan Project, New York, NY 10013, USA.
The challenge of treating gay men with AIDS.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):202-10. Unique Identifier : AIDSLINE MED/96029588; Sheran M; AIDS Center Program, St. Vincent's Hospital, New York, NY 10011,; USA.
Caring for HIV-infected drug users: a provider's perspective.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):211-6. Unique Identifier : AIDSLINE MED/96029589; Selwyn PA; HIV/AIDS Program, Yale-New Haven Hospital, CT, USA.
Understanding the needs of children.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):217-25. Unique Identifier : AIDSLINE MED/96029590; Garcia A; Department of Pediatrics, University of Miami, FL 33101, USA.
HIV-infected health care workers. The personal impact.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):226-39. Unique Identifier : AIDSLINE MED/96029591; Scoles P
HIV-infected health care workers. The legal perspective.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):240-62. Unique Identifier : AIDSLINE MED/96029592; Strama BT
Supporting and advocating for HIV-positive health care workers.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):263-72. Unique Identifier : AIDSLINE MED/96029593; Schatz B; Gay and Lesbian Medical Association, San Francisco, CA 94114,; USA.
AIDS and politics: death and taxes.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):273-82. Unique Identifier : AIDSLINE MED/96029594; Westmoreland TM; Federal Legislation Clinic, Georgetown University Law Center,; Washington, DC 20001, USA.
Historical and analytical overview of policy issues affecting women living with AIDS: a blueprint for learning from our past.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):283-99. Unique Identifier : AIDSLINE MED/96029595; Cooper EB; Fordham School of Law, USA.
The provider as advocate.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):300-8. Unique Identifier : AIDSLINE MED/96029596; Zealand TP; AIDS Resource Foundation for Children Inc., Newark, NJ, USA.
Miles to go before we sleep.: Bull N Y Acad Med. 1995 Summer;72(1 Suppl):309-15. Unique Identifier : AIDSLINE MED/96029597; Goosby EP; Department of Health and Human Services, Washington, DC 20201,; USA.
A witness to unconditional love.: Nurs Spectr (Wash D C). 1995 Nov 27;5(24):10. Unique Identifier : AIDSLINE MED/96138806; Harlan MT
Cutaneous manifestations of non-HIV immunosuppression.: Br J Hosp Med. 1995 Oct 18-31;54(8):395-9. Unique Identifier : AIDSLINE MED/96126726; Child FJ; Higgins EM; Department of Dermatology, King's College Hospital, London.; Advances in organ transplantation and chemotherapeutic techniques have led to an increased interest in both the early and long-term complications of immunosuppression. This article reviews many of the cutaneous complications and highlights the importance of regular skin surveillance in these patients.
Immunohistological findings in patients with superficial bladder carcinoma after intravesical instillation of keyhole limpet haemocyanin.: Br J Urol. 1995 Dec;76(6):702-7. Unique Identifier : AIDSLINE MED/96138045; Jurincic-Winkler C; Metz KA; Beuth J; Engelmann U; Klippel KF; Department of Urology, General Hospital Celle, Germany.; OBJECTIVE: To determine whether keyhole limpet haemocyanin (KLH) instilled intravesically improves the local cellular response within the bladder wall of patients suffering from superficial bladder carcinoma. PATIENTS AND METHODS: Twelve patients (10 men and two women, mean age 67 years, range 42-85) with superficial
Infectious colitides in patients with acquired immunodeficiency syndrome.: Gastroenterologist. 1995 Sep;3(3):241-8. Unique Identifier : AIDSLINE MED/96051483; Mosenkis BN; Simon D; Department of Gastroenterology, Albert Einstein College of; Medicine, Bronx, NY, USA.; Diarrhea is a common problem in patients with acquired immunodeficiency syndrome (AIDS), and infections of the colon constitute a significant etiology. Cytomegalovirus ( CMV ) is the most common opportunistic infection of the colon in patients with AIDS, and it ca
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.: Structure. 1995 Sep 15;3(9):879-92. Unique Identifier : AIDSLINE MED/96097395; Georgiadis MM; Jessen SM; Ogata CM; Telesnitsky A; Goff SP; Hendrickson WA; Waksman Institute, Rutgers University, Piscataway, NJ 08855, USA.; BACKGROUND: Reverse transcriptase (RT) converts the single-stranded RNA genome of a retrovirus into a double-stranded DNA copy for integration into the host genome. This process requires ribonuclease H as well as RNA- and DNA-directed DNA polymerase activities. Although the overall organization of HIV-1 RT is known fr
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.: Structure. 1995 Sep 15;3(9):915-26. Unique Identifier : AIDSLINE MED/96097398; Ren J; Esnouf R; Hopkins A; Ross C; Jones Y; Stammers D; Stuart D; Laboratory of Molecular Biophysics, Oxford, UK.; BACKGROUND: HIV reverse transcriptase (RT) is a key target of anti-AIDS therapies. Structural studies of HIV-1 RT, unliganded and complexed with different non-nucleoside inhibitors (NNIs), have pointed to a common mode of binding and inactivation through distortion of the polymerase catalytic site by NNIs containing t
Increased soluble tumor necrosis factor receptor expression and release by human immunodeficiency virus type 1 infection.: J Interferon Cytokine Res. 1995 Sep;15(9):749-57. Unique Identifier : AIDSLINE MED/96097341; Kalinkovich A; Geleziunas R; Kemper O; Belenki D; Wallach D; Wainberg MA; Bentwich Z; R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University Medical School, Rehovot, Israel.; High levels of circulating soluble tumor necrosis factor receptors (sTNF-R) are associated with HIV-1 infection and disease. To understand better this association, we have investigated p55 and p75 TNF-R expression on peripheral blood mononuclear cell (PBMC) subsets and in the promonocytic cell line U937, with or witho
Culture of tumour-infiltrating lymphocytes from melanoma and colon carcinoma: removal of tumour cells does not affect tumour-specificity.: Cancer Immunol Immunother. 1995 Nov;41(5):293-301. Unique Identifier : AIDSLINE MED/96132673; Mulder WM; Stukart MJ; Roos M; van Lier RA; Wagstaff J; Scheper RJ; Bloemena E; Department of Pathology, Free University Hospital, Amsterdam, The; Netherlands.; The therapeutic potential of adoptive therapy using tumour-infiltrating lymphocytes (TIL) has been demonstrated in a number of clinical trials. However, freshly isolated tumour-infiltrating lymphocytes (TIL) are often impaired in their proliferative and cytotoxic responses, which limits their use in immunotherapy. Sev
Prevention of AIDS in Sri Lanka: are we doing the best for our people? [letter]: Ceylon Med J. 1995 Sep;40(3):127-8. Unique Identifier : AIDSLINE MED/96070082; Arulanantham T
Relationships between humoral factors in HIV-1-infected mothers and the occurrence of HIV infection in their infants.: Clin Exp Immunol. 1995 Dec;102(3):476-80. Unique Identifier : AIDSLINE MED/96128135; Mabondzo A; Rouvier P; Raoul H; Le Naour R; Courpotin C; Herve F; Parnet-Mathieu F; Lasfargues G; Dormont D; Service de Neurovirologie, CEA, CRSSA/DSV/DRM,; Fontenay-aux-Roses, France.; Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including
Cell cycling in HIV infection: analysis of in vivo activated lymphocytes.: Clin Exp Immunol. 1995 Dec;102(3):481-6. Unique Identifier : AIDSLINE MED/96128136; Mahalingam M; Pozniak A; McManus TJ; Vergani D; Peakman M; Department of Immunology, King's College School of Medicine and; Dentistry, London, UK.; Infection with HIV results in increased circulating levels of T lymphocytes expressing phenotypic markers of immune activation. In the present study, using three-colour immunofluorescence, we examined the cell cycle status of these activated cells. Activated (HLA-DR+, CD25+ and CD38+) CD4+ and CD8+ T lymphocytes in pe
An immunosuppressive murine leukaemia virus induces a Th1-->Th2 switch and abrogates the IgM antibody response to sheep erythrocytes by suppressing the production of IL-2.: Clin Exp Immunol. 1995 Dec;102(3):487-95. Unique Identifier : AIDSLINE MED/96128137; Faxvaag A; Espevik T; Dalen A; Institute of Cancer Research, University of Trondheim, Medisinsk; Teknisk Centre, Norway.; Many retroviruses have tropism for cells in the immune system and have a propensity to induce immunosuppression in the host. Some of the effects of retroviruses on immune cell function are thought to be mediated through cytokines. Friend ImmunoSuppressive virus-2 (FIS-2) is a low oncogenic murine leukaemia virus (MuLV
[Interferons in the therapy of solid tumors]: Clin Ter. 1995 Aug-Sep;146(8-9):491-502. Unique Identifier : AIDSLINE MED/96120217; Tomao S; Mozzicafreddo A; Raffaele M; Romiti A; Papo MA; Campisi C; Istituto Nazionale per la ricerca sul cancro, Policlinico Umberto; I di Roma.; Belonging to the vast family of cytokines, interferons (IFN) have recently been widely investigated concerning their possible clinical applications, both in virology and oncology. In this field results have been quite mixed but definitely encouraging. The best achievements have been obtained in hematology, and particu
T-cell repertoire of normal, rejected, and pathological corneas: phenotype and function.: Cornea. 1995 Sep;14(5):450-6. Unique Identifier : AIDSLINE MED/96037081; Wackenheim-Urlacher A; Kantelip B; Falkenrodt A; Piqot X; Tongio MM; Montard M; Delbosc B; Department d'Ophtalmologie, CHU Jean Minjoz, Besancon, France.; The specific immune mechanisms of corneal graft rejection are not completely understood. Recently, the technique of growing T-cell lines from rejected allografts using recombinant IL-2 has enabled the cells involved in allograft rejection to be recognized. In the prese
Ecchymotic Kaposi's sarcoma.: Cutis. 1995 Aug;56(2):104-6. Unique Identifier : AIDSLINE MED/96047049; Schwartz RA; Spicer MS; Thomas I; Janniger CK; Lambert WC; Dermatology, Pathology, and Pediatrics, New Jersey Medical; School, Newark 07103-2714, USA.; We report two patients with ecchymotic patches that did not suggest the diagnosis of Kaposi s sarcoma. The principal complaint of one patient was facial and periorbital edema with bilateral periorbital ecchymosis. On his trunk were patches resembling pityriasis rosea-like Kaposi s sarcoma. Both types of lesions proved
Current management of von Willebrand's disease.: Drugs. 1995 Oct;50(4):602-14. Unique Identifier : AIDSLINE MED/96106617; Castaman G; Rodeghiero F; Department of Haematology and Haemophilia, San Bortolo Hospital,; Vicenza, Italy.; von Willebrand s disease (vWD) is the most frequent inherited disorder and is the result of a deficiency and/or abnormality of von Willebrand factor (vWF). As a consequence, the level of factor VIII, the presence of which reflects the ability of vWF to stabilise it, is usually low. Bleeding time, which reflects the ab
Fluconazole. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients.: Drugs. 1995 Oct;50(4):658-90. Unique Identifier : AIDSLINE MED/96106621; Goa KL; Barradell LB; Adis International Limited, Auckland, New Zealand.; Fluconazole is a triazole antifungal agent which is now an established part of therapy in patients with immune deficiencies. It is effective against oropharyngeal/oesophageal candidiasis (candidosis) when used orally once daily either as treatment or secondary prophylaxis in patients with AIDS or as treatment or prima
Electrophysiological characteristics of lesions in facial palsies of different etiologies. A study using electrical and magnetic stimulation techniques.: Electroencephalogr Clin Neurophysiol. 1995 Dec;97(6):355-68. Unique Identifier : AIDSLINE MED/96136130; Rosler KM; Magistris MR; Glocker FX; Kohler A; Deuschl G; Hess CW; Department of Neurology, University of Berne, Inselspital,; Switzerland.; Using magnetic stimulation techniques in addition to conventional electrical stimulation, the entire facial motor pathway can be assessed electrophysiologically. To study the diagnostic yield of these examinations, 174 patients with facial palsies of a variety of etiologies were examined (85 Bell s palsies, 24 Guillai
Nontuberculous mycobacterial infection in HIV-negative patients receiving immunosuppressive therapy.: Eur J Clin Microbiol Infect Dis. 1995 Sep;14(9):755-63. Unique Identifier : AIDSLINE MED/96120942; Skogberg K; Ruutu P; Tukiainen P; Valtonen VV; Department of Bacteriology and Immunology, University of; Helsinki, Finland.; The clinical significance of nontuberculous mycobacterial isolates and presentation of mycobacteriosis was compared in HIV-negative patients with or without preceding immunosuppression. Patients with nontuberculous mycobacterial isolates (n = 139), mainly from the respiratory system, were divided into three groups: th
Multicenter evaluation of a new commercial assay for detection of immunoglobulin M antibodies to Toxoplasma gondii. Multicenter Study Group.: Eur J Clin Microbiol Infect Dis. 1995 Sep;14(9):787-93. Unique Identifier : AIDSLINE MED/96120947; Luyasu V; Robert AR; Schaefer L; Macioszek J; Clinique Saint-Pierre, Ottignies-Louvain-La-Neuve, Belgium.; A new commercial assay for detection of IgM-specific antibodies to Toxoplasma gondii (IMx Toxo IgM, Abbott, USA), based on microparticle enzyme immunoassay technology, was evaluated at 15 clinical sites in Europe and the USA. Performance characteristics were established by testing clinical specimens collected randomly
Rate of detection of human herpesvirus-6 at different stages of HIV infection.: Eur J Clin Microbiol Infect Dis. 1995 Sep;14(9):820-4. Unique Identifier : AIDSLINE MED/96120956; Gautheret A; Aubin JT; Fauveau V; Rozenbaum W; Huraux JM; Agut H; Laboratoire de Virologie, Centre National de Recherche; Scientifique, CERVI, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.; In a cross-sectional study, human herpesvirus-6 (HHV-6) infection was analysed by means of polymerase chain reaction in peripheral blood mononuclear cells (PBMCs) and saliva from 125 HIV-seropositive subjects and 29 HIV-seronegative controls. HHV-6 was detected in saliva significantly more frequently in HIV-seronegati
Activated CD4+ and CD8+ cells in the colonic mucosa of ulcerative colitis patients: their relationship to HLA-DR antigen expression on the colonic epithelium and serum soluble CD25 levels.: Digestion. 1995;56(6):516-22. Unique Identifier : AIDSLINE MED/96127519; Sasakawa T; Takizawa H; Bannai H; Narisawa R; Asakura H; 3rd Department of Internal Medicine, Niigata University School of; Medicine, Japan.; This study was performed to clarify the relationship between activated (HLA-DR-expressing) CD4+ and CD8+ cells in the colonic lamina propria of ulcerative colitis and other immunological factors, i.e., epithelial DR expression, serum soluble CD25 levels, and colonic mucosal CD25+ cells. The frequency of epithelial DR
Acceptability of shared care for asymptomatic HIV-positive patients.: Fam Pract. 1995 Sep;12(3):299-302. Unique Identifier : AIDSLINE MED/96115495; Grun L; Murray E; Department of Primary Health Care, UCLMS, Whittington Hospital,; Highgate Hill, London, UK.; In Britain, Human Immunodeficiency Virus (HIV) disease has been seen as an illness requiring specialist hospital care at all times. However, as its chronic nature has become apparent, the possibiliity that it could be managed more cost effectively in primary care has been raised. This has led to increasing interest in
Gastric toxoplasmosis in acquired immunodeficiency syndrome: antemortem diagnosis with histopathologic characterization.: Gastroenterology. 1996 Jan;110(1):258-64. Unique Identifier : AIDSLINE MED/96121015; Alpert L; Miller M; Alpert E; Satin R; Lamoureux E; Trudel L; Department of Medicine, Jewish General Hospital, Montreal,; Quebec, Canada.; Gastrointestinal symptoms attributable to Toxoplasma gondii infection are distinctly unusual, and antemortem diagnosis of gastrointestinal involvement is rarely documented, particularly in the absence of cerebral manifestations or disseminated disease. This case report describes a rare example of T. gondii infection o
Investigating diarrhea in patients with acquired immunodeficiency syndrome [editorial; comment]: Gastroenterology. 1996 Jan;110(1):296-8. Unique Identifier : AIDSLINE MED/96121021; Crotty B; Smallwood RA
Chronic unexplained diarrhea in human immunodeficiency virus infection: determination of the best diagnostic approach [see comments]: Gastroenterology. 1996 Jan;110(1):30-7. Unique Identifier : AIDSLINE MED/96120989; Wilcox CM; Schwartz DA; Cotsonis G; Thompson SE 3rd; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia, USA.; BACKGROUND & AIMS: Chronic unexplained diarrhea is a common complication of human immunodeficiency virus infection, although the best diagnostic approach is unknown. The purpose of our study was to evaluate the clinical use of endoscopy for the evaluation of this problem. METHODS: Patients infected with human immun
Gastroscopic findings in Mediterranean Kaposi's sarcoma (non-AIDS).: Gastrointest Endosc. 1995 Oct;42(4):336-9. Unique Identifier : AIDSLINE MED/96121326; Kolios G; Kaloterakis A; Filiotou A; Nakos A; Hadziyannis S; Gastroenterology Department, Hippokration Hospital, Athens,; Greece.; The frequency and degree of gastrointestinal involvement in patients with Mediterranean Kaposi s sarcoma (non-AIDS), a newly recognized form of Kaposi s sarcoma, is unknown. Eighty-seven patients with Mediterranean Kaposi s sarcoma proven by skin and/or nodal biopsy underwent endoscopic study of the upper gastrointest
A technique to examine the underlying mucosa in patients with AIDS and severe Candida esophagitis.: Gastrointest Endosc. 1995 Oct;42(4):360-3. Unique Identifier : AIDSLINE MED/96121332; Wilcox CM; Emory University School of Medicine, Division of Digestive; Diseases, Atlanta, GA 30303, USA.
Prevalence of HTLV-I-associated uveitis in the Kanto Plain, Japan.: Graefes Arch Clin Exp Ophthalmol. 1995 Aug;233(8):476-8. Unique Identifier : AIDSLINE MED/96002923; Ishioka M; Goto K; Nakamura S; Watanabe N; Uchio E; Saeki K; Ohno S; Schepens Eye Research Institute, Boston, MA 02114, USA.; BACKGROUND: Seroprevalence of antibody to human T-lymphotropic virus type I (HTLV-I) is high in the island of Kyushu, Japan . Reports on the etiological analysis of HTLV-I in patients with uveitis primarily document cases in this island. We studied the seroprevalence of HTLV-I at the
Molecular characterization of human monoclonal antibodies specific for several HIV proteins: analysis of the VH3 family expression.: Immunol Lett. 1995 Jul-Aug;47(1-2):107-12. Unique Identifier : AIDSLINE GENBANK/Z35126; David D; Goossens D; Desgranges C; Theze J; Zouali M; Unite d'Immunogenetique Cellulaire, Institut Pasteur, Paris,; France.; We have analyzed the heavy-chain variable (VH) region genes expressed by a panel of human monoclonal antibodies derived from an immunized volunteer, an AIDS patient and seropositive asymptomatic donors, and specific for HIV-1 env, pol and gag gene products. The third complementarity-determining regions show a high com
HIV and the colonic route of entry: effect of inflammatory cytokines on the binding of HIV-gp120 and T cells to human enterocytes.: Immunol Lett. 1995 Jul-Aug;47(1-2):139-40. Unique Identifier : AIDSLINE MED/96087594; Flores-Romo L; Bacon KB; Estrada-Garcia T; Life PF; Aubry JP; Bonnefoy JY; Escobar-Gutierrez A; Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Jacalin, a lectin interacting with O-linked sugars and mediating protection of CD4+ cells against HIV-1, binds to the external envelope glycoprotein gp120.: Immunol Lett. 1995 Jul-Aug;47(1-2):141-3. Unique Identifier : AIDSLINE MED/96087595; Corbeau P; Pasquali JL; Devaux C; Centre de Tri des Molecules anti-HIV, CNRS UPR9008, INSERM U249,; Montpellier, France.
Autoreactive T-cell line derived from PBMC of a rhesus macaque immunized with inactivated SIV vaccine.: Immunol Lett. 1995 Jul-Aug;47(1-2):145-6. Unique Identifier : AIDSLINE MED/96087596; Teng XC; Ashworth LA; Department of Immunopathology, CAMR, Salisbury, UK.
Further evidence for the relationship of HIV-1 gp120 V3 loops with Ig superfamily members: similarity with the putative CDR3 region of T-cell receptor delta-chains.: Immunol Lett. 1995 Jul-Aug;47(1-2):25-8. Unique Identifier : AIDSLINE MED/96087575; Metlas R; Skerl V; Veljkovic V; Pongor S; Laboratory for Multidisciplinary Research, Institute for Nuclear; Sciences Vinca, Belgrade, Yugoslavia.; Twenty-five V3 loops of envelope gp 120 extracted from 30 HIV-1 isolates were compared with T-cell receptor (TCR) subunits variable (V) portions using pairwise alignments of 11-residue peptides. The results indicate that, in comparison with random sequences, the analyzed V3 loops, unlike control (unrelated) sequences,
Sequential occurrence of IgM, IgM/IgG, and gp120-IgM/IgG complement complexes on CD4+ lymphocytes in relation to CD4+ blood lymphocyte depletion in HIV+ hemophilia patients: results of a 10-year study.: Immunol Lett. 1995 Jul-Aug;47(1-2):97-102. Unique Identifier : AIDSLINE MED/96087587; Daniel V; Susal C; Weimer R; Zipperle S; Kropelin M; Zimmermann R; Huth-Kuhne A; Opelz G; Department of Transplantation Immunology, Institute of; Immunology, Heidelberg, Germany.; The concept of autoimmune mechanisms playing an integral role in the pathogenesis of HIV disease is rapidly gaining ground. In this study, we determined IgM and IgG antibodies, complement fragments and gp120 on the surface of CD4+ lymphocytes using double-fluorescence flow cytometry. Sequential analysis demonstrated a
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.: Immunogenetics. 1996;43(1-2):6-12. Unique Identifier : AIDSLINE GENBANK/U34882; Johnson-Tardieu JM; Walworth EW; Cornelius JG; Ye X; Schuster SM; Peck AB; Department of Pathology & Laboratory Medicine, University of; Florida College of Medicine, Gainesville 32610, USA.; Predisposition to Type I insulin-dependent diabetes (IDD) has a strong underlying genetic basis involving class II major histocompatibility complex (MHC) genes as well as several non-MHC genetic systems. In the non-obese diabetic (NOD) mouse, a model for human IDD, genes associated with the appearance of immune cell i
Chemotherapy for AIDS-related and endemic African Kaposi's sarcoma in southern Africa.: OURNAL ARTICLE Int J Dermatol. 1995 Oct;34(10):729-32. Unique Identifier : AIDSLINE MED/96122066; Stein ME; Lachter J; Spencer D; Bezwoda WR; Northern Israel Oncology Center, Rambam Medical Center, Haifa,; Israel.
Design, synthesis, and characterization of HIV-1 enhancer-binding polypeptides derived from bacteriophage 434 repressor.: Int J Pept Protein Res. 1995 Sep-Oct;46(3-4):333-40. Unique Identifier : AIDSLINE MED/96122184; Stadler K; Liu N; Trotman L; Hiltpold A; Caderas G; Klauser S; Hehlgans T; Gutte B; Biochemical Institute of Zurich University, Switzerland.; We have designed and synthesized HIV-1 enhancer-binding polypeptides that were derived from bacteriophage 434 repressor. These peptides were 39-54 residues long and contained either the recognition helix or the entire helix-turn-helix motif of the DNA-binding domain of 434 repressor. The dissociation constant of the c
Ketoconazole and itraconazole susceptibility of Candida albicans isolated from patients infected with HIV.: J Antimicrob Chemother. 1995 Jul;36(1):109-18. Unique Identifier : AIDSLINE MED/96051682; St-Germain G; Dion C; Espinel-Ingroff A; Ratelle J; de Repentigny L; Quebec Public Health Laboratory, Sainte-Anne-de-Bellevue, Canada.; Two hundred and fifty-five isolates of Candida albicans were collected from 93 patients infected with HIV during the course of a clinical trial comparing ketoconazole with itraconazole for the treatment of oropharyngeal or oesophageal candidosis. The susceptibility of the isolates to both drugs was determined by incub
Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice during treatment with clarithromycin.: J Antimicrob Chemother. 1995 Jul;36(1):129-36. Unique Identifier : AIDSLINE MED/96051684; Doucet-Populaire F; Truffot-Pernot C; Grosset J; Jarlier V; Laboratoire de Bacteriologie-Virologie, Faculte de Medecine; Pitie-Salpetriere, Paris, France.; Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium complex (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 x 10(-9). Clarithromycin resistant strains of MAC isolated in AIDS patients a
Arkansas HIV/AIDS report 1983-1995.: J Ark Med Soc. 1995 Dec;92(7):348-9. Unique Identifier : AIDSLINE MED/96147483
Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays.: J Biol Chem. 1995 Dec 29;270(52):31046-51. Unique Identifier : AIDSLINE MED/96125081; Gu Z; Quan Y; Li Z; Arts EJ; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, Montreal, Quebec, Canada.; We have employed a cell-free human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) assay to study the effects of non-nucleoside inhibitors of RT (NNRTI) by directly monitoring specific HIV DNA products using a HIV-1 genome-derived template and an oligodeoxynucleotide primer. As previously shown by our
A unique thyroid hormone response element in the human immunodeficiency virus type 1 long terminal repeat that overlaps the Sp1 binding sites.: J Biol Chem. 1995 Dec 29;270(52):31059-64. Unique Identifier : AIDSLINE MED/96125083; Rahman A; Esmaili A; Saatcioglu F; Department of Pharmacology, School of Medicine, University of; California, San Diego, La Jolla 92093-0636, USA.; Long terminal repeat (LTR) of human immunodeficiency virus (HIV) type 1 is activated by thyroid hormone (T3) receptor alpha (T3R alpha) in the absence of ligand. Addition of T3 reverses this effect. This activity is mediated by a high affinity T3 response element (T3RE) within the HIV-1 LTR, termed the HIV-T3RE (bases
DNA probe hybridisation in microwells using a new bioluminescent system for the detection of PCR-amplified HIV-1 proviral DNA.: J Virol Methods. 1995 Oct;55(2):185-97. Unique Identifier : AIDSLINE MED/96116854; Zammatteo N; Moris P; Alexandre I; Vaira D; Piette J; Remacle J; Laboratoire de Biochimie Cellulaire, Facultes Notre-Dame de la; Paix, Namur, Belgium.; A new bioluminescent detection system combined with a sandwich DNA hybridisation reaction in microwells has been developed for the detection of human immunodeficiency virus type 1 (HIV-1) provirus DNA amplified by the polymerase chain reaction (PCR). First, a fragment of the HIV-1 gag gene was amplified. The amplified
Role of apoptosis in HIV disease pathogenesis.: J Clin Immunol. 1995 Sep;15(5):217-31. Unique Identifier : AIDSLINE MED/96108690; Oyaizu N; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York, New York 11030,; USA.; After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a kil
Anti-CD3-induced changes in protein kinase C isozymes expression in human CD4+ and CD8+ T lymphocytes.: J Clin Immunol. 1995 Sep;15(5):232-41. Unique Identifier : AIDSLINE MED/96108691; Harris W; Gollapudi S; Gupta S; Division of Basic and Clinical Immunology, University of; California, Irvine 92717, USA.; In order to determine whether there is a differential expression and activation of PKC isozymes between CD4+ and CD8+ T cells, peripheral blood mononuclear cells were stimulated with anti-CD3 monoclonal antibody (moAb) for various time intervals and the expression of calcium-dependent PKC isozymes (alpha, beta, gamma)
Testing healthcare staff for infection with HIV and hepatitis: logistic and ethical considerations.: J Clin Pathol. 1995 Oct;48(10):885-9. Unique Identifier : AIDSLINE MED/96138149; Newell A; Barton SE; Department of HIV/Genitourinary Medicine, St Stephen's Clinic,; Chelsea Hospital, London.
Use of dried blood spots for the detection and confirmation of HTLV-I specific antibodies for epidemiological purposes.: J Clin Pathol. 1995 Oct;48(10):904-7. Unique Identifier : AIDSLINE MED/96138153; Parker SP; Taylor MB; Ades AE; Cubitt WD; Peckham C; Department of Virology, Institute of Child Health, London.; AIMS--To modify and evaluate a gelatin particle agglutination test that could provide a sensitive, specific and inexpensive method for the detection of HTLV-I antibody in dried blood spot samples (DBS) collected on filter paper. METHODS--A set of 26 reference samples confirmed as HTLV-I antibody positive were assemble
Acute hepatic and renal failure caused by Pneumocystis carinii in patients with AIDS.: J Clin Pathol. 1995 Oct;48(10):975-8. Unique Identifier : AIDSLINE MED/96138173; Boldorini R; Guzzetti S; Meroni L; Quirino T; Cristina S; Monga G; Dipartimento di Scienze Mediche, II Facolta di Medicina e; Chirurgia di Novara-Universita di Torino, Italy.; Clinical and pathological findings are described in two AIDS patients with Pneumocystis carinii infection who received prophylactic treatment with nebulised pentamidine and developed unusual hepatic and renal failure. Histological examination showed clumps of P carinii massively obstructing hepatic sinuses and portal
Cerumen impaction in the elderly.: J Gerontol Nurs. 1995 Dec;21(12):43-5. Unique Identifier : AIDSLINE MED/96138729; Meador JA; 1. Cerumen impaction is a reversible cause of conduction hearing loss in the elderly. 2. Risk factors include ear canal hairs, hearing aids, bony growths secondary to osteophyte or osteoma, and a history of impacted cerumen. 3. Cerumen removal can cause damage to the external auditory meatus, perforation of the tympan
Rules on HIV testing of source patients [news]: Infect Control Hosp Epidemiol. 1995 Sep;16(9):525. Unique Identifier : AIDSLINE MED/96089582; Pugliese G
Liposome-encapsulated (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for long-acting therapy of viral retinitis.: J Infect Dis. 1996 Jan;173(1):18-23. Unique Identifier : AIDSLINE MED/96132458; Kuppermann BD; Assil KK; Vuong C; Besen G; Wiley CA; De Clercq E; Bergeron-Lynn G; Connor JD; Pursley M; Munguia D; Freeman WR; Department of Ophthalmology, University of California, San Diego,; La Jolla 92093, USA.; The effect of liposome-encapsulated (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC; cidofovir) was evaluated as prophylaxis in a rabbit model of experimentally induced retinitis caused by preretinal inoculation of herpes simplex virus type 1 (HSV-1). Cidofovir (100 micrograms) in liposomes (0.1 mL) was inj
Risk factors for fluconazole-resistant candidiasis in human immunodeficiency virus-infected patients.: J Infect Dis. 1996 Jan;173(1):219-25. Unique Identifier : AIDSLINE MED/96132485; Maenza JR; Keruly JC; Moore RD; Chaisson RE; Merz WG; Gallant JE; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21287-6220, USA.; In a case-control study to identify risk factors for fluconazole-resistant oroesophageal candidiasis in human immunodeficiency virus-infected patients, 25 patients with clinical and in vitro fluconazole-resistant candidiasis were paired with controls who had treatment-responsive candidiasis and who had been observed f
Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers.: J Infect Dis. 1996 Jan;173(1):232-6. Unique Identifier : AIDSLINE MED/96132487; Chappell CL; Okhuysen PC; Sterling CR; DuPont HL; Center for Infectious Diseases, University of Texas School of; Public Health, Houston 77030, USA.; Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human immunodeficiency virus. In addition, experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection respo
Use of intrinsic and extrinsic helper epitopes for in vivo induction of anti-hepatitis C virus cytotoxic T lymphocytes (CTL) with CTL epitope peptide vaccines.: J Infect Dis. 1996 Jan;173(1):24-31. Unique Identifier : AIDSLINE MED/96132459; Shirai M; Chen M; Arichi T; Masaki T; Nishioka M; Newman M; Nakazawa T; Feinstone SM; Berzofsky JA; Department of Microbiology, Yamaguchi University School of; Medicine, Japan.; The induction of virus-specific cytotoxic T lymphocytes (CTL) is an important part of vaccine strategy. CTL induction in vivo by two hepatitis C virus (HCV) peptides containing CTL epitopes, one from the NS5 region (P17) and one from the core (C7), was compared. P17 required covalent attachment of a helper peptide (PC
A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa.: J Infect Dis. 1996 Jan;173(1):245-8. Unique Identifier : AIDSLINE MED/96132490; Ariyoshi K; Berry N; Wilkins A; Ricard D; Aaby P; Naucler A; Ngom PT; Jobe O; Jaffar S; Dias F; Tedder RS; Whittle H; Medical Research Council Laboratories, Banjul, Gambia.; A community-based study of provirus load in human immunodeficiency virus (HIV) type 2-infected subjects was done in a rural village in Guinea-Bissau . HIV-2 provirus load varied considerably, with a geometric mean of 124.3 (95% confidence interval, 86.0-179.6) copies/10(5) CD4 cell
Frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative Kaposi's sarcoma.: J Infect Dis. 1996 Jan;173(1):248-51. Unique Identifier : AIDSLINE MED/96132491; Chuck S; Grant RM; Katongole-Mbidde E; Conant M; Ganem D; Howard Hughes Medical Institute, University of California, San; Francisco 94143, USA.; While Kaposi s sarcoma (KS) is extremely common in homosexual men infected with human immunodeficiency virus (HIV), it is also found in several clinical settings in which HIV infection is absent. Recently, sequences from the genome of a novel member of the herpesvirus family have been identified within KS biopsies in
Disseminated Mycobacterium avium complex infection in AIDS: immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D.: J Infect Dis. 1996 Jan;173(1):259-62. Unique Identifier : AIDSLINE MED/96132494; Haug CJ; Aukrust P; Lien E; Muller F; Espevik T; Froland SS; Medical Department A, Univeristy of Oslo, Norway.; Disseminated Mycobacterium avium complex (MAC) infection is associated with considerable morbidity and mortality in patients with AIDS. Because both tumor necrosis factor-alpha (TNF-alpha) and 1,25-dihydroxyvitamin D3 (1,25D) may be involved in the normal control of MAC infection, these parameters were studied in AIDS
Mycobacterium avium complex sputum isolates from patients with respiratory symptoms in Guinea-Bissau.: J Infect Dis. 1996 Jan;173(1):263-5. Unique Identifier : AIDSLINE MED/96132495; Koivula T; Hoffner S; Winqvist N; Naucler A; Dias F; Lacerda L; Svenson S; Norberg R; Kallenius G; Swedish Institute for Infectious Disease Control, Karolinska; Institute, Stockholm, Sweden.; In total, 814 patients with clinically suspected tuberculosis were examined at the Raoul Follerau Hospital in Bissau, Guinea-Bissau . Sputum samples were collected, and cultures were grown on Lowenstein-Jensen medium. Isolates were further characterized by standard biochemical meth
Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients.: J Infect Dis. 1996 Jan;173(1):265-8. Unique Identifier : AIDSLINE MED/96132496; Suzuki Y; Wong SY; Grumet FC; Fessel J; Montoya JG; Zolopa AR; Portmore A; Schumacher-Perdreau F; Schrappe M; Koppen S; Ruf B; Brown BW; Remington JS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, CA 94301, USA.; The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had
Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni.: J Infect Dis. 1996 Jan;173(1):269-72. Unique Identifier : AIDSLINE MED/96132497; Sabin EA; Araujo MI; Carvalho EM; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, New York 14853-6401, USA.; After vaccination with tetanus toxoid (TT), TT-specific immune responses in humans infected with Schistosoma mansoni were assessed. Peripheral blood mononuclear cells (PBMC) from vaccinated infected subjects and vaccinated uninfected controls were evaluated for their ability to produce cytokines characteristic of Th1
Population pharmacokinetics of didanosine in patients with human immunodeficiency virus infection [letter; comment]: J Infect Dis. 1996 Jan;173(1):273. Unique Identifier : AIDSLINE MED/96132498; Harb GE; Mandema JW; Delahunty T; Benowitz NB; Coleman R; Sheiner LB; Jacobson MA
Protection of MN-rgp120-immunized chimpanzees from heterologous infection with a primary isolate of human immunodeficiency virus type 1.: J Infect Dis. 1996 Jan;173(1):52-9. Unique Identifier : AIDSLINE MED/96132463; Berman PW; Murthy KK; Wrin T; Vennari JC; Cobb EK; Eastman DJ; Champe M; Nakamura GR; Davison D; Powell MF; Bussiere J; Francis DP; Matthews T; Gregory TJ; Obijeski JF; Department of Immunology, Genentech, Inc., South San Francisco,; California 94080, USA.; Three chimpanzees immunized with recombinant gp120 from human immunodeficiency virus type 1 (HIV-1) strain MN and 1 control animal were challenged intravenously with a primary isolate of HIV-1SF2. Viral infection was detected in the control animal by viral culture, polymerase chain reaction, and multiple serologic ass
Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors.: J Infect Dis. 1996 Jan;173(1):60-7. Unique Identifier : AIDSLINE MED/96132464; Montefiori DC; Pantaleo G; Fink LM; Zhou JT; Zhou JY; Bilska M; Miralles GD; Fauci AS; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Serum antibodies from human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were evaluated for virus neutralization and infection enhancement in vitro. Sera from LTNPs had higher average titers of neutralizing antibodies to HIV-1 strains IIIB and MN and more frequently ne
Laboratory diagnosis of infection status in infants perinatally exposed to human immunodeficiency virus type 1.: J Infect Dis. 1996 Jan;173(1):68-76. Unique Identifier : AIDSLINE MED/96132465; Paul MO; Tetali S; Lesser ML; Abrams EJ; Wang XP; Kowalski R; Bamji M; Napolitano B; Gulick L; Bakshi S; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030, USA.; Accurate and timely diagnosis of infection status in infants born to women infected with human immunodeficiency virus (HIV) is of paramount importance. The comparative accuracy of five diagnostic decision rules was evaluated in 208 HIV-exposed infants (32 infected, 176 uninfected) based on laboratory testing during th
Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-gamma.: J Infect Dis. 1996 Jan;173(1):7-17. Unique Identifier : AIDSLINE MED/96132457; Mikloska Z; Kesson AM; Penfold ME; Cunningham AL; Virology Department, Westmead Hospital, Australia.; In early recurrent herpetic lesions, CD4 T lymphocytes are the predominant infiltrating cells, and keratinocytes expressing major histocompatibility complex (MHC) class II antigens, induced by interferon-gamma (IFN-gamma), are the major site of herpes simplex virus (HSV) replication. IFN-gamma pretreatment of human ke
Factors associated with cytomegalovirus infection among human immunodeficiency virus type 1-seronegative and -seropositive women from an urban minority community.: J Infect Dis. 1996 Jan;173(1):77-82. Unique Identifier : AIDSLINE MED/96132466; Clarke LM; Duerr A; Feldman J; Sierra MF; Daidone BJ; Landesman SH; Department of Pathology, State University of New York Health; Science Center at Brooklyn 11203, USA.; Cytomegalovirus ( CMV ) seroprevalence and genital tract shedding in human immunodeficiency virus (HIV)-seronegative and HIV-seropositive women from an urban minority community were investigated. CMV seropositivity was high in both groups: 181 (95.2%) of 190 HIV-n
Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: results from a randomized trial.: J Infect Dis. 1996 Jan;173(1):83-90. Unique Identifier : AIDSLINE MED/96132467; Ahmed F; Steinhoff MC; Rodriguez-Barradas MC; Hamilton RG; Musher DM; Nelson KE; Department of Epidemiology, Johns Hopkins University School of; Public Health, Baltimore, MD 21205, USA.; Adults (n = 282) were randomized to receive either a pneumococcal glycoprotein conjugate vaccine, composed of pneumococcal serotypes 6B, 14, 18C, 19F, and 23F linked to CRM197, or a 23-valent pneumococcal polysaccharide vaccine. Among human immunodeficiency virus (HIV)-uninfected persons, conjugate vaccine elicited si
Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Group.: J Infect Dis. 1996 Jan;173(1):91-7. Unique Identifier : AIDSLINE MED/96132468; Leport C; Chene G; Morlat P; Luft BJ; Rousseau F; Pueyo S; Hafner R; Miro J; Aubertin J; Salamon R; Vilde JL; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Universite Paris 7, France.; Pyrimethamine (50 mg) with folinic acid (15 mg) given three times weekly was assessed as primary prophylaxis for toxoplasmic encephalitis (TE) in 554 human immunodeficiency virus-infected patients seropositive for Toxoplasma gondii and with
[Progress on antiviral agents]: Nippon Naika Gakkai Zasshi. 1995 Sep 10;84(9):1555-8. Unique Identifier : AIDSLINE MED/96056922; Shigeta S
[Recent trend of tuberculosis]: Nippon Naika Gakkai Zasshi. 1995 Sep 10;84(9):1600-4. Unique Identifier : AIDSLINE MED/96056931; Shimokata K
Transdermal delivery of dideoxynucleoside-type anti-HIV drugs. 1. Stability studies for hairless rat skin permeation.: J Pharm Sci. 1995 Sep;84(9):1061-6. Unique Identifier : AIDSLINE MED/96079215; Kim DD; Chien YW; Controlled Drug-Delivery Research Center, Rutgers, State; University of New Jersey, College of Pharmacy, Piscataway 08854,; USA.; The stability of dideoxynucleoside-type anti-HIV drugs in solution when in contact with hairless rat skin was investigated in order to study the feasibility of their transdermal delivery. The freshly excised dorsal region of hairless rat skin was mounted on Valia-Chien skin permeation cells, and both epidermis (donor)
Preformulation studies of a novel HIV protease inhibitor, AG1343.: J Pharm Sci. 1995 Sep;84(9):1090-3. Unique Identifier : AIDSLINE MED/96079220; Longer M; Shetty B; Zamansky I; Tyle P; Department of Pharmaceutical Development, Agouron Pharmaceuticals; Inc., San Diego, CA 92121, USA.; AG1343 is a novel human immunodeficiency virus (HIV) protease inhibitor designed using protein structure-based techniques and intended for chronic oral administration in the treatment of AIDS-related conditions. The compound is the mesylate salt of a basic amine with a molecular weight of 663.90, pKa of 6.0, and parti
High numbers of T cells in gingiva from patients with human immunodeficiency virus (HIV) infection.: J Oral Pathol Med. 1995 Oct;24(9):413-9. Unique Identifier : AIDSLINE MED/96122624; Odden K; Schenck K; Hurlen B; Department of Oral Biology, Dental Faculty, University of Oslo,; Norway.; A quantitative, immunohistologic evaluation of CD3+, CD4+ and CD8+ cells was carried out on gingival biopsies from 25 HIV-infected persons with gingivitis or periodontitis and 13 HIV-seronegative persons with periodontitis. CD3+ T cells were found in all biopsies. CD8+ cells were significantly more numerous and the CD
[Primary immunodeficiency diseases]: Nippon Rinsho. 1995 Nov;53(11):2821-6. Unique Identifier : AIDSLINE MED/96081682; Mukaida N; Department of Pharmacology, Kanazawa University.; A substantial proportion of patients with primary immunodeficiency diseases develop tumors, particularly those of lymphoreticular system caused by Epstein-Barr virus (EBV). Primary immunodeficiency renders patients susceptible to EBV by reducing immune reactions and surveillance abilities against the virus or inducing
[Gene structure and transformation mechanism of HTLV-I]: Nippon Rinsho. 1995 Nov;53(11):2837-45. Unique Identifier : AIDSLINE MED/96081684; Matsumoto K; Osaka Red Cross Blood Center.; HTLV-I is the etiological agent of the adult T cell leukemia. HTLV-I genome contains the novel pX region in addition to the genes common to all retroviruses. Tax, encoded at the pX region, may play a central role in cellular transformation, however, little information is available on the mechanism. Tax transactivates
Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.: J Cell Biochem Suppl. 1995;22:117-25. Unique Identifier : AIDSLINE MED/96010322; Prochaska HJ; Chavan SJ; Baron P; Polsky B; Molecular Pharmacology and Therapeutics Program, Memorial; Sloan-Kettering Cancer Center, New York, NY 10021, USA.; Glutathione (GSH) levels are markedly depleted in patients infected with human immunodeficiency virus type 1 (HIV-1) and supplementation of media with high concentrations (5-20 mM) of low-molecular weight thiols prevents HIV-1 replication in cultured cells. We were intrigued whether chemopreventive enzyme inducers mig
Pneumocystis carinii pneumonia without acquired immunodeficiency syndrome: who should receive prophylaxis? [editorial; comment]: Mayo Clin Proc. 1996 Jan;71(1):102-3. Unique Identifier : AIDSLINE MED/96133651; Sepkowitz KA
Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy [see comments]: Mayo Clin Proc. 1996 Jan;71(1):5-13. Unique Identifier : AIDSLINE MED/96133636; Yale SH; Limper AH; Division of Pulmonary and Critical Care Medicine and Internal; Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.; OBJECTIVE: To determine the clinical spectrum of immunosuppressive conditions and systemic corticosteroid therapy associated with the development of Pneumocystis carinii pneumonia in a consecutive series of patients without acquired immunodeficiency syndrome (AIDS). DESIGN: We retrospectively analyzed a consecutive se
[Current status of tuberculosis in Spain. A precarious health care perspective with regard to developed countries]: Med Clin (Barc). 1995 Nov 25;105(18):703-7. Unique Identifier : AIDSLINE MED/96122949; Rey R; Ausina V; Casal M; Cayla J; de March P; Moreno S; Munoz F; Ortega A; Vidal R; Vidal ML; Instituto de Salud Carlos III Centro de Investigacion Clinica,; Sinesio Delgado, Madrid.
[Aspergillus tracheobronchitis in a patient with AIDS (letter)]: Med Clin (Barc). 1995 Nov 25;105(18):717. Unique Identifier : AIDSLINE MED/96122954; Arizcorreta Yarza A; Clavo Sanchez A; Giron Gonzalez JA; Bascunana Quirell A
English HIV and AIDS projections made [news]: Lancet. 1996 Jan 13;347(8994):109. Unique Identifier : AIDSLINE MED/96133037; Ramsay S
Danes' AIDS education criticised [news]: Lancet. 1996 Jan 13;347(8994):114. Unique Identifier : AIDSLINE MED/96133039; Skovmand K
Pneumocystis carinii pneumonia in Africa [letter; comment]: Lancet. 1996 Jan 13;347(8994):126; discussion 126-7. Unique Identifier : AIDSLINE MED/96133064; Gilks C; Squire B
HIV quantification: clinical applications.: Lancet. 1996 Jan 13;347(8994):71-3. Unique Identifier : AIDSLINE MED/96133024; Volberding PA; AIDS Program, San Francisco General Hospital, CA, USA.
On the interpretation of data from isothermal processes.: Methods Enzymol. 1995;259:628-720. Unique Identifier : AIDSLINE MED/96108468; Lumry R; Department of Chemistry, University of Minnesota, Minneapolis; 55455, USA.
If it's the virus, why aren't we measuring it? [editorial]: Med J Aust. 1995 Nov 20;163(10):508-9. Unique Identifier : AIDSLINE MED/96130135; Emery S; Carr A; Cooper DA
World AIDS Day: what progress since last year? [editorial]: Med J Aust. 1995 Dec 4-18;163(11-12):566. Unique Identifier : AIDSLINE MED/96132303; Cooper DA
The Australian Medical Support Force in Rwanda.: Med J Aust. 1995 Dec 4-18;163(11-12):646-51. Unique Identifier : AIDSLINE MED/96132331; Ramsey W; Bridgford LR; Lusby RJ; Pearn JH; Land Headquarters, Victoria Barracks, Paddington, NSW.; In the aftermath of the Rwandan civil war, Australia s defence forces deployed a medical force to support the United Nations Assistance Mission. In this article, Wayne Ramsey, Commander of the Australian contingent, Lindsay R Bridgford, Officer Commanding Bravo Section, Robert J Lusby, Lt.-Colonel (Surgeon), Australia
[Distribution and phylogenetic analysis of HTLV-I isolates, persisting in the Russian Far East]: Mol Biol (Mosk). 1995 Sep-Oct;29(5):1172-82. Unique Identifier : AIDSLINE MED/96093198; Yamashita M; Seniuta NB; Pavlish OA; Miura T; Syrtsev AV; Gurova EP; Stepina VN; Ibuki K; Susova OIu; Shcherbak LN; et al
Blood products [letter; comment]: Nature. 1996 Jan 4;379(6560):14. Unique Identifier : AIDSLINE MED/96135127; Prince AM
Sensitization of cells and retroviruses to human serum by (alpha 1-3) galactosyltransferase.: Nature. 1996 Jan 4;379(6560):85-8. Unique Identifier : AIDSLINE MED/96135140; Takeuchi Y; Porter CD; Strahan KM; Preece AF; Gustafsson K; Cosset FL; Weiss RA; Collins MK; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.; Mammalian C-type retroviruses are inactivated by human serum, following triggering of the classical complement cascade. This may have inhibited transmission to humans of C-type oncoviruses from other mammals. Indeed, the retroviruses human immunodeficiency virus and human T-cell leukaemia virus are resistant to human
Virology. New trick from an old foe [news; comment]: Nature. 1996 Jan 18;379(6562):208-9. Unique Identifier : AIDSLINE MED/96138374; Cullen BR
Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein [see comments]: Nature. 1996 Jan 18;379(6562):273-7. Unique Identifier : AIDSLINE MED/96138386; Diaz JJ; Dodon MD; Schaerer-Uthurralt N; Simonin D; Kindbeiter K; Gazzolo L; Madjar JJ; Universite Claude Bernard, Lyon-1/CNRS UMR30, Faculte de; Medecine, Lyon, France.; Herpes simplex virus type 1 (HSV-1) Us11 protein, a true late gene product packaged within the virion, is delivered into cells after infection, exhibits a nucleocytoplasmic localization at early times, and later accumulates in the nucleoli. This RNA-binding basic phosphoprotein, capable of oligomerization, is supposed
Serum secretory IgA and IgM and free secretory component in IgA nephropathy.: Nephron. 1995;71(1):75-8. Unique Identifier : AIDSLINE MED/96042417; Mole CM; Renoult E; Bene MC; Seilles E; Kessler M; Revillard JP; Faure GC; GRIP, Jeune Equipe DRED 251, Laboratoire d'Immunologie Faculte; de Medecine, CHU Nancy, France.; IgA nephropathy (IgAN) is characterized by the presence of IgA and C3 deposits in the mesangium. Mesangial IgA is mostly dimeric IgA1 with a J chain, lacking a secretory component. In view of the recent demonstration of elevated serum levels of secretory component and secretory IgA in liver disease and HIV infection a
The TH1/TH2 concept and its relevance to renal disorders and transplantation immunity [editorial]: Nephrol Dial Transplant. 1995;10(8):1282-4. Unique Identifier : AIDSLINE MED/96052523; Goldman M; Druet P
Pediatric spinal infections.: Orthop Clin North Am. 1996 Jan;27(1):111-23. Unique Identifier : AIDSLINE MED/96133777; Glazer PA; Hu SS; Department of Orthopaedic Surgery, University of California, San; Francisco, USA.; A high index of suspicion for spinal infection and an appropriate and prompt diagnosis are essential for the treatment of pediatric spinal infections. A 3-week course of antibiotics and supportive therapy is effective in the majority of cases of discitis, the most common pediatric spinal infection. Patients who are no
Spinal infections in the immunocompromised host.: Orthop Clin North Am. 1996 Jan;27(1):37-46. Unique Identifier : AIDSLINE MED/96133769; Broner FA; Garland DE; Zigler JE; Department of Surgery, Rancho Los Amigos Medical Center, Downey,; California, USA.; There is an increasing population of immunocompromised patients with HIV, IV drug abuse, organ transplantation, and long-term steroid treatment developing spinal infections. Delayed diagnosis because of blunted host immune response and lack of outward signs and symptoms places the treating physician at a disadvantage
[Azithromycin: new orientations]: Pathol Biol (Paris). 1995 Jun;43(6):547-50. Unique Identifier : AIDSLINE MED/96099671; Coulaud JP; Institut de Medecine et d'Epidemiologie Africaines, Fondation; Leon-MBA, Paris, France.
[Azithromycin and Mycobacterium avium infection]: Pathol Biol (Paris). 1995 Jun;43(6):565-7. Unique Identifier : AIDSLINE MED/96099675; Perronne C; Service des Maladies Infectieuses et Tropicales, Hopital; Raymond-Poincare, Garches, France.; Mycobacterium avium infection is a frequent complication during the late stage of AIDS. M. avium is resistant or poorly susceptible to classical antituberculosis drugs. Some new macrolide antibiotics such as clarithromycin or azithromycin are bactericidal against M. avium, and their use has dramatically improved the p
Trials of strength [news]: Nurs Times. 1995 Nov 29-Dec 5;91(48):14-5. Unique Identifier : AIDSLINE MED/96140086; Day M
A positive contribution.: Nurs Times. 1995 Nov 29-Dec 5;91(48):62-4. Unique Identifier : AIDSLINE MED/96140101; Willis J
Cancer resources in the United States.: Oncol Nurs Forum. 1995 Oct;22(9):1421-32. Unique Identifier : AIDSLINE MED/96147482; Kinsey R; Doty T; Oncology Nursing Society Education Committee.
Therapeutic uses of intravenous immunoglobulin (IVIG) in children.: Pediatr Rev. 1995 Nov;16(11):403-10; quiz 410. Unique Identifier : AIDSLINE MED/96108790; Ramesh S; Schwartz SA; Division of Allergy and Immunology, Buffalo General Hospital,; State University of New York, USA.
[Pneumococcal septic arthritis in HIV infection]: Presse Med. 1995 Nov 4;24(33):1566-8. Unique Identifier : AIDSLINE MED/96142373; Trivalle C; Cremieux AC; Carbon C; Service de Medecine interne, Hopital Bichat, Paris.; Infections due to pneumococci are frequent in patients infected with the human immunodeficiency virus (HIV), but joint infections are rare. We observed two cases of septic arthritis due to pneumococci in two non-haemophilic HIV seropositive patients. In the first case, a 31-year old drug addict who had undergone splen
[Invasive anal carcinoma in a homosexual patient with HIV infection (letter)]: Presse Med. 1995 Nov 4;24(33):1577. Unique Identifier : AIDSLINE MED/96142376; Drobacheff C; Van Landuyt H; Mougin C; Bosset JP; Laurent R
[Methemoglobin in AIDS (letter)]: Recenti Prog Med. 1995 Nov;86(11):463-4. Unique Identifier : AIDSLINE MED/96124661; Ansovini R
Epidemiology and prevention of hepatitis type C in Italy.: Res Virol. 1995 Jul-Aug;146(4):253-9. Unique Identifier : AIDSLINE MED/96050174; Zanetti AR; Tanzi E; Romano L; Mele A; Istituto di Virologia, Universita di Milano, Italia.; Viral hepatitis type C is of public health importance in all parts of the world. In Italy , hepatitis C accounts for approximately 18% of the annually reported cases of acute viral hepatitis. The national rate of acute non-A, non-B hepatitis (the majority of which are hepatitis C) ha
[Nurses get together to discuss AIDS. Quality of life, an endless search]: Rev Enferm. 1995 Sep;18(205):33-4. Unique Identifier : AIDSLINE MED/96140143
Randomized study of sulfamethoxazole-trimethoprim versus aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with AIDS.: Scand J Infect Dis. 1995;27(3):217-20. Unique Identifier : AIDSLINE MED/96143360; Nielsen TL; Jensen BN; Nelsing S; Mathiesen LR; Skinhoj P; Nielsen JO; Department of Infectious Diseases, University Hospital Hvidovre,; Copenhagen, Denmark.; In a prospective, randomized open-label trial, the efficacy of sulfamethoxazole-trimethoprim (SMX-TMP) 400/80 mg b.i.d. was compared with the efficacy of aerosolized pentamidine (AP) 60 mg every 2nd week as secondary prophylaxis (SP) against recurrence of Pneumocystis carinii pneumonia (PCP) in AIDS patients. 94 patie
Fluconazole for primary prophylaxis of AIDS-associated cryptococcosis: a case-control study.: Scand J Infect Dis. 1995;27(3):235-7. Unique Identifier : AIDSLINE MED/96143363; Ammassari A; Linzalone A; Murri R; Marasca G; Morace G; Antinori A; Department of Infectious Diseases, Catholic University, Rome,; Italy.; In order to verify whether fluconazole has a prophylactive effect against the occurrence of cryptococcosis in HIV-infected patients and to identify other factors capable of increasing or reducing the risk of this infection, we arranged a case-control study of 17 patients with cryptococcal infection. 34 controls were s
An unusual gastrointestinal presentation of leishmaniasis.: Scand J Infect Dis. 1995;27(3):297-8. Unique Identifier : AIDSLINE MED/96143374; McBride MO; Fisher M; Skinner CJ; Golden R; Main J; Department of Genitourinary Medicine and Communicable Diseases,; St. Mary's Hospital, London, UK.; While visceral leishmaniasis (VL) generally occurs in immunocompetent subjects in endemic areas, it has been increasingly recognised as an important opportunistic infection in the immunocompromised including those infected with the human immunodeficiency virus. We report an unusual presentation of visceral leishmanias
[HIV and pregnancy]: Schweiz Med Wochenschr. 1995 Dec 2;125(48):2322-9. Unique Identifier : AIDSLINE MED/96105969; Rudin C; Camli C; Schnuriger H; Biedermann K; Lauper U; Kind C; Universitats-Kinderklinik Basel.; Since 1990 216 HIV-infected pregnant women have been enrolled in an ongoing nationwide study named HIV and Pregnancy financed by the Swiss Federal Office of Health (No. 90-7007 and 93-7131). Of a total of 228 recorded pregnancies 154 continued to parturition. Until now it has been definitively established whether or n
AIDS trials take on peer review [news]: Science. 1996 Jan 5;271(5245):20-1. Unique Identifier : AIDSLINE MED/96138414; Cohen J
[Routines for infection testing and vaccination against hepatitis B among applicants for asylum. A questionnaire study among health personnel responsible for reception of asylum applicants]: Tidsskr Nor Laegeforen. 1995 Oct 20;115(25):3128-30. Unique Identifier : AIDSLINE MED/96072330; Dramsdahl M; Sandvik H; Helsetjenesten for flyktninger, Bergen.; The authors performed a questionnaire survey to investigate the current routines for screening applicants for asylum for hepatitis B virus, HIV and intestinal parasites, and for vaccination against hepatitis B. The response rate was 82% (n = 80). Of the respondents, 58% were physicians, 23% public health nurses and 18
Human fetal islet transplantation in IDDM patients: an 8-year experience.: Transplant Proc. 1995 Dec;27(6):3146-7. Unique Identifier : AIDSLINE MED/96125465; Dordevic PB; Lalic NM; Brkic S; Jotic A; Paunovic I; Lalic K; Dimitrijevic V; Dragasevic M; Zamaklar M; Popovic S; et al; Diabetes Center, Institute for Endocrinology, Belgrade,; Yugoslavia.
Cellular requirements for pancreatic islet xenograft rejection.: Transplant Proc. 1995 Dec;27(6):3302-3. Unique Identifier : AIDSLINE MED/96125544; Ahn M; Chang E; Chu G; Barker CF; Markmann JF; American Heart Association, Philadelphia, PA, USA.
A new way of looking at aspartic proteinase structures: a comparison of pepsin structure to other aspartic proteinases in the near active site region.: Adv Exp Med Biol. 1995;362:19-32. Unique Identifier : AIDSLINE MED/96073615; Andreeva NS; Bochkarev A; Pechik I; V. Enhelhardt Institute of Molecular Biology, Russian Academy of; Sciences, Moscow, Russia.
Mechanism of autoprocessing of a mini-precursor of the aspartic protease of human immunodeficiency virus type 1.: Adv Exp Med Biol. 1995;362:379-86. Unique Identifier : AIDSLINE MED/96073662; Co E; Koelsch G; Hartsuck JA; Tang J; Protein Studies Program, Oklahoma Medical Research Foundation,; Oklahoma City, USA.
Mutants of HIV-1 protease with enhanced stability to autodegradation.: Adv Exp Med Biol. 1995;362:387-98. Unique Identifier : AIDSLINE MED/96073663; Tomasselli AG; Mildner AM; Rothrock DJ; Sarcich JL; Lull J; Leone J; Heinrikson RL; Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001,; USA.
Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency.: Adv Exp Med Biol. 1995;362:399-406. Unique Identifier : AIDSLINE MED/96073664; Cameron CE; Burstein H; Bizub-Bender D; Ridky T; Weber IT; Wlodawer A; Skalka AM; Leis J; Case Western Reserve University, School of Medicine, Cleveland,; Ohio 44106-4935, USA.
Inhibitor-resistant mutants of the HIV-1 aspartic protease.: Adv Exp Med Biol. 1995;362:407-11. Unique Identifier : AIDSLINE MED/96073665; Korant BD; DuPont Merck Virus Laboratory, Glenolden, PA 19036, USA.
Design and synthesis of HIV protease inhibitors containing allophenylnorstatine as a transition-state mimic.: Adv Exp Med Biol. 1995;362:413-23. Unique Identifier : AIDSLINE MED/96073666; Kiso Y; Department of Medicinal Chemistry, Kyoto Pharmaceutical; University, Japan.
Breaking the shackles of the genetic code: engineering retroviral proteases through total chemical synthesis.: Adv Exp Med Biol. 1995;362:425-38. Unique Identifier : AIDSLINE MED/96073667; Kent SB; Baca M; Elder J; Miller M; Milton R; Milton S; Rao JK; Schnolzer M; Scripps Research Institute, La Jolla, California 92037, USA.
X-ray structure of a tethered dimer for HIV-1 protease.: Adv Exp Med Biol. 1995;362:439-44. Unique Identifier : AIDSLINE MED/96073668; Bhat TN; Baldwin ET; Liu B; Cheng YS; Erickson JW; Structural Biochemistry Program, Frederick Biomedical; Supercomputing Center, PRI/DynCorp, National Cancer Institute,; Frederick Cancer Research and Development Center, MD 21702-1201,; USA.
Structure of HIV-1 protease with KNI-272: a transition state mimetic inhibitor containing allophenylnorstatine.: Adv Exp Med Biol. 1995;362:445-9. Unique Identifier : AIDSLINE MED/96073669; Baldwin ET; Bhat TN; Gulnik S; Liu B; Kiso Y; Mitsuya H; Erickson JW; NCI-Frederick Cancer Research and Development Center,; PRI/DynCorp, Structural Biochemistry Program, Frederick, Maryland; 21702, USA.
Molecular dynamics of HIV-1 protease in complex with a difluoroketone-containing inhibitor: implications for the catalytic mechanism.: Adv Exp Med Biol. 1995;362:451-4. Unique Identifier : AIDSLINE MED/96073670; Silva AM; Cachau RE; Baldwin ET; Gulnik S; Sham HL; Erickson JW; Structural Biochemistry Program, PRI/Dyn Corp, NCI-Frederick; Cancer Research and Development Center, Maryland 21702, USA.
Activated dynamics of flap opening in HIV-1 protease.: Adv Exp Med Biol. 1995;362:455-60. Unique Identifier : AIDSLINE MED/96073671; Collins JR; Burt SK; Erickson JW; Structural Biochemistry Program, Frederick Biomedical; Supercomputing Center, PRI/DynCorp, National Cancer Institute,; Frederick Cancer Research and Development Center, MD 21702-1201,; USA.
Computer simulation and analysis of the reaction pathway for the decomposition of the hydrated peptide bond in aspartic proteases.: Adv Exp Med Biol. 1995;362:461-5. Unique Identifier : AIDSLINE MED/96073672; Cachau RE; Topol IA; Burt SK; Silva AM; Erickson JW; Structural Biochemistry Program, PRI/DynCorp, National Cancer; Institute, Frederick Cancer Research and Development Center, MD; 21702-1210, USA.
Activities of precursor and tethered dimer forms of HIV proteinase.: Adv Exp Med Biol. 1995;362:467-72. Unique Identifier : AIDSLINE MED/96073673; Phylip LH; Griffiths JT; Mills JS; Graves MC; Dunn BM; Kay J; Department of Biochemistry, University of Wales, Cardiff, U.K.
Site-directed mutagenesis of HIV-1 protease: generation of mutant proteases with increased stability to autodigestion.: Adv Exp Med Biol. 1995;362:473-7. Unique Identifier : AIDSLINE MED/96073674; Tomasselli AG; Mildner AM; Rothrock DJ; Sarcich JL; Lull J; Leone J; Heinrikson R; Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001,; USA.
Molecular modeling of the structure of FIV protease.: Adv Exp Med Biol. 1995;362:479-84. Unique Identifier : AIDSLINE MED/96073675; Gustchina A; Macromolecular Structure Laboratory, ABL-Basic Research Program,; National Cancer Institute, Frederick Cancer Research and; Development Center, Maryland, USA.
AIDS and esophageal tuberculosis.: Am J Gastroenterol. 1995 Dec;90(12):2237-8. Unique Identifier : AIDSLINE MED/96097962; Quader Z; Go BT; Atten MJ; Imam S; Nadimpalli V; Attar BM; Division of Gastroenterology, Cook County Hospital, Chicago,; Illinois 60612, USA.
Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol.: Antimicrob Agents Chemother. 1995 Sep;39(9):1993-9. Unique Identifier : AIDSLINE MED/96050731; Nair V; St. Clair MH; Reardon JE; Krasny HC; Hazen RJ; Paff MT; Boone LR; Tisdale M; Najera I; Dornsife RE; et al; Department of Chemistry, University of Iowa, Iowa City 52242,; USA.; 4(S)-(6-Amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol (IsoddA) is the most antivirally active member of a novel class of optically active isomeric dideoxynucleosides in which the base has been transposed from the natural 1 position to the 2 position and the absolute configuration is (S,S). IsoddA was active agai
Anti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptase.: Antimicrob Agents Chemother. 1995 Sep;39(9):2000-7. Unique Identifier : AIDSLINE MED/96050732; Fujihashi T; Hara H; Sakata T; Mori K; Higuchi H; Tanaka A; Kaji H; Kaji A; Department of Pharmacology, Jefferson Medical College,; Philadelphia, Pennsylvania 19107, USA.; Halogenated gomisin J (a derivative of lignan compound), represented by the bromine derivative 1506 [(6R, 7S, S-biar)-4,9-dibromo-3,10-dihydroxy-1,2,11,12-tetramethoxy-6, 7-dimethyl-5,6,7,8- tetrahydrodibenzo[a,c]cyclo-octene], was found to be a potent inhibitor of the cytopathic effects of human immunodeficiency viru
Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T).: Antiviral Res. 1995 Jun;27(3):189-203. Unique Identifier : AIDSLINE MED/96145330; Riddler SA; Anderson RE; Mellors JW; Division of Infectious Diseases, University of Pittsburgh Medical; Center, PA 15213, USA.; Stavudine , 2 ,3 -didehydro-3 -deoxythymidine (D4T), is a potent inhibitor of HIV-1 reverse transcriptase in vitro. In clinical studies, stavudine has excellent oral bioavailability in excess of 80%. The dose-limiting toxicity is
Antiviral properties of simple difunctionalized enols targeted to the HIV-1 protease.: Antiviral Res. 1995 Jun;27(3):205-18. Unique Identifier : AIDSLINE MED/96145331; Vaillancourt M; Sauve G; Cohen E; Departement de Microbiologie et d'Immunologie, Universite de; Montreal, Quebec, Canada.; The human immunodeficiency virus type 1 (HIV-1) protease catalyses the specific cleavage of the virion structural polyproteins p55gag and p160gag-pol and is, therefore, essential for viral maturation. We have previously reported a series of low molecular weight non-peptidic enol-based compounds that inhibit the HIV-1
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.: Antiviral Res. 1995 Jun;27(3):219-36. Unique Identifier : AIDSLINE MED/96145332; Balzarini J; Brouwer WG; Felauer EE; De Clercq E; Karlsson A; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; A large variety of carboxanilide derivates in which the original oxathiin moiety present in the prototype compound UC84 was replaced by a non-cyclic lipophilic entity has been evaluated for their inhibitory effect against wild-type human immunodeficiency virus type 1 (HIV-1/IIIB) and several mutant viruses derived the
Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2'- and 5'-positions of the sugar moiety.: Antiviral Res. 1995 Jun;27(3):281-99. Unique Identifier : AIDSLINE MED/96145337; Ingate S; Perez-Perez MJ; De Clercq E; Balzarini J; Camarasa MJ; Instituto de Quimica Medica (C.S.I.C.), Madrid, Spain.; Novel analogues of the anti-HIV-1 agent TSAO-T, [1-[2 ,5 -bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]thymine]-3 -spiro-5-(4- amino- 1,2-oxathiole-2,2-dioxide) and its 3-methyl counterpart TSAO-m3T were obtained by modifications at positions 2 or 5 of the sugar moiety. These compounds were evaluated for th
Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine.: Antiviral Res. 1995 Jun;27(3):301-16. Unique Identifier : AIDSLINE MED/96145338; Nave JF; Taylor D; Tyms S; Kenny M; Eggenspiller A; Eschbach A; Dulworth J; Brennan T; Piriou F; Halazy S; Marion Merrell Dow Research Institute, Strasbourg, France.; (E)-9-(5-Phosphonopent-4-enyl)guanine and (E)-9-[3-(hydroxymethyl)-5- phosphonopent-4-enyl]guanine which bear a vinyl phosphonate moiety as a mimic of the phosphate group were synthesized. Their activities against human immunodeficiency virus type-1 (HIV-1), herpes simplex virus type-1 (HSV-1) and human
In vitro and in vivo enhancement of ddI activity against Rauscher murine leukemia virus by ribavirin.: Antiviral Res. 1995 Jun;27(3):317-23. Unique Identifier : AIDSLINE MED/96145339; Allen LB; Quenelle DC; Westbrook L; Taylor BA; Prichard MN; Brazier AD; Hollingshead MG; Shannon WM; Microbiology Research Department, Southern Research Institute,; Birmingham, AL 35205, USA.; Ribavirin has been reported to enhance the activity of ddI against HIV. We explored this enhancement of antiviral activity in Rauscher murine leukemia virus (RMuLV) models in vitro and in vivo. The significant finding in these studies was that combinations of the drugs exhibited virus titer reductions that were greate
Novel sulfonated and phosphonated analogs of distamycin which inhibit the replication of HIV.: Antiviral Res. 1995 Aug;27(4):335-54. Unique Identifier : AIDSLINE MED/96049782; Clanton DJ; Buckheit RW Jr; Terpening SJ; Kiser R; Mongelli N; Borgia AL; Schultz R; Narayanan V; Bader JP; Rice WG; Anti-AIDS Virus Drug Screening Laboratory, Program Resources,; Inc./Dyncorp, NCI-Frederick Cancer Research and Development; Center, MD 21702-1201, USA.; A series of novel distamycin-related polyanionic compounds were compared for their anti-HIV activity. Several were highly potent inhibitors of HIV virus-induced cell killing and viral replication of a wide variety of laboratory isolates, as well as a monocytotropic virus and a clinical isolate in human peripheral bloo
Differential inhibition of reverse transcriptase and cellular DNA polymerase-alpha activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix.: Antiviral Res. 1995 Aug;27(4):367-74. Unique Identifier : AIDSLINE MED/96049784; Chang CW; Lin MT; Lee SS; Liu KC; Hsu FL; Lin JY; Institute of Biochemistry, College of Medicine, National Taiwan; University, Taiwan.; Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-alpha (HDNAP-alpha) activity. Fifty
Pharmacokinetics of zidovudine and didanosine during combination therapy.: Antiviral Res. 1995 Aug;27(4):419-24. Unique Identifier : AIDSLINE MED/96049788; Morse GD; Shelton MJ; Ho M; Bartos L; DeRemer M; Ragni M; Department of Pharmacy Practice, State University of New York at; Buffalo 14260, USA.; While the combination of zidovudine and didanosine is used in HIV-infected patients with more advanced disease, the possibility of a pharmacokinetic interaction between these two drugs remains controversial. Zidovudine doses of 50, 100, and 200 mg, combined with 67, 167, and 250 mg of didanosine were evaluated in 11 a
[Hemichorea associated with cerebral toxoplasmosis and AIDS (letter)]: Arq Neuropsiquiatr. 1995 Sep;53(3-A):534. Unique Identifier : AIDSLINE MED/96085613; de Mattos JP; de Rosso AL; Correa RB; Novis S
Combination foscarnet and ganciclovir therapy vs monotherapy for the treatment of relapsed cytomegalovirus retinitis in patients with AIDS. The Cytomegalovirus Retreatment Trial. The Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group.: Arch Ophthalmol. 1996 Jan;114(1):23-33. Unique Identifier : AIDSLINE MED/96133209; OBJECTIVES: To determine the best therapeutic regimen, using currently approved drugs, for treatment of relapsed cytomegalovirus ( CMV ) retinitis. DESIGN: Multicenter, randomized, controlled clinical trial. SETTING: Ophthalmol
Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate.: Arch Ophthalmol. 1996 Jan;114(1):66-71. Unique Identifier : AIDSLINE MED/96133215; Adamis AP; Shima DT; Tolentino MJ; Gragoudas ES; Ferrara N; Folkman J; D'Amore PA; Miller JW; Department of Opthalmology, Massachusetts Eye and Ear Infirmary,; Boston, USA.; OBJECTIVE: To determine if the angiogenic peptide vascular endothelial growth factor (VEGF) is required for retinal ischemia-associated iris neovascularization in a nonhuman primate. METHODS: Laser retinal vein occlusion was used to produce retinal ischemia in 16 eyes of eight animals (Macaca fascicularis). Eyes were
Antiretroviral therapy of human immunodeficiency virus type-1 (HIV-1) infection.: Aust N Z J Med. 1995 Aug;25(4):344-9. Unique Identifier : AIDSLINE MED/96092772; Emery S; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; NCHECR, Faculty of Medicine, University of New South Wales,; Sydney, Australia.
[The trends by province of tuberculosis in Cuba: 1979-1993]: Bol Oficina Sanit Panam. 1995 Nov;119(5):396-404. Unique Identifier : AIDSLINE MED/96128332; Gonzalez Ochoa E; Armas Perez L; Machin Gelaber A; Instituto Pedro Kouri, Grupo de Vigilancia e Investigaciones de; Tuberculosis e Infecciones Respiratorias Agudas, La Habana, Cuba.; This study was carried out in order to describe tuberculosis trends in Cuba and its provinces between 1979 and 1993. For this purpose, reports of new cases of all forms of tuberculosis were obtained from the National Statistics Bureau of the Ministry of Public Health. In addition, tu
Antibodies to LMP2A/2B in EBV-carrying malignancies.: Eur J Cancer. 1995 Oct;31A(11):1875-8. Unique Identifier : AIDSLINE MED/96138112; Lennette ET; Winberg G; Yadav M; Enblad G; Klein G; Virolab, Inc., Berkeley, California 94710, USA.; Antibodies to the Epstein-Barr virus (EBV)-encoded membrane proteins, LMP2A and LMP2B, were assayed in 540 individuals, including 154 patients with nasopharyngeal carcinoma, 16 with African Burkitt s lymphoma, 113 with Hodgkin s disease, 14 with EBV-carrying gastric carcinoma, 14 with oral hairy leucoplakia (HIV+ pati
Reliability of interview responses of injecting drug users.: J Addict Dis. 1995;14(2):1-12. Unique Identifier : AIDSLINE MED/96073763; Ross MW; Stowe A; Wodak A; Gold J; Center for Health Promotion Research and Development, School of; Public Health, University of Texas at Houston 77225, USA.; We compared 23 injecting drug users (IDUs) who were part of a larger study at retest periods of less than or greater than one month for test-retest reliability of their responses to a detailed questionnaire covering demographics, drug use, HIV risk behavior and attitudes and knowledge about HIV. Data indicated that th
Cancer in AIDS.: Curr Opin Oncol. 1995 Sep;7(5):B89-90. Unique Identifier : AIDSLINE MED/96076287
New insights into peripheral T-cell lymphomas.: Curr Opin Oncol. 1995 Sep;7(5):408-14. Unique Identifier : AIDSLINE MED/96076274; DeCoteau JF; Kadin ME; Beth Israel Hospital, Boston, Massachusetts, USA.; Peripheral T-cell lymphomas comprise a morphologically diverse group of malignant lymphoproliferative disorders that arise from postthymic T cells. Currently, there exists no universally accepted system of classification of peripheral T-cell lymphoma. Recent efforts to elucidate pathogenetic mechanisms and define reco
Cancer in AIDS [editorial]: Curr Opin Oncol. 1995 Sep;7(5):427-8. Unique Identifier : AIDSLINE MED/96076277; Ambinder RF
Treatment strategies for epidemic Kaposi's sarcoma.: Curr Opin Oncol. 1995 Sep;7(5):429-36. Unique Identifier : AIDSLINE MED/96076278; Volm MD; von Roenn JH; Northwestern University Medical School, Chicago, Illinois, USA.; As the AIDS epidemic progresses, Kaposi s sarcoma continues to contribute substantially to the morbidity suffered by AIDS patients. Advances in our understanding of the pathogenesis of Kaposi s sarcoma have resulted in treatment strategies that are being investigated in the laboratory and clinic. Agents that affect th
Human papillomavirus-associated malignancies in HIV-positive men and women.: Curr Opin Oncol. 1995 Sep;7(5):437-41. Unique Identifier : AIDSLINE MED/96076279; Palefsky J; Medical Center, University of California at San Francisco 94143,; USA.; Human papillomavirus (HPV) infections of the anogenital tract and HPV-associated anogenital neoplasia are commonly found in HIV-positive men and women. Although there is little evidence suggesting that the incidence of invasive cervical cancer is increased in HIV-positive women, the incidence of invasive anal cancer m
Treatment of AIDS-related lymphomas.: Curr Opin Oncol. 1995 Sep;7(5):442-9. Unique Identifier : AIDSLINE MED/96076280; Sparano JA; Albert Einstein Cancer Center, Bronx, NY, USA.; Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin s lymphoma . Patients with systemic non-Hodgkin s lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognos
An integrated approach to the epidemiology of Kaposi's sarcoma.: Curr Opin Oncol. 1995 Sep;7(5):450-5. Unique Identifier : AIDSLINE MED/96076281; Jacobson LP; Armenian HK; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, MD 21205, USA.; As an AIDS-defining illness, Kaposi s sarcoma primarily occurs among HIV-infected homosexual men in developed countries and among men and women in Africa. Except in Africa, Kaposi s sarcoma was rarely diagnosed prior to the AIDS epidemic. The clustering of cases geographically and by gender suggest an environmental in
Electrical stimulation of the sciatic nerve alters neuropeptide content and lymphocyte migration in the subcutaneous tissue of the rat hind paw.: Neuroreport. 1995 Sep 11;6(13):1773-7. Unique Identifier : AIDSLINE MED/96098653; Herzberg U; Murtaugh MP; Mullet MA; Beitz AJ; Department of Veterinary PathoBiology, University of Minnesota,; St. Paul 55108, USA.; To study the possible mechanism by which peripheral nerves mediate immune responses in target tissues, electrical stimulation of the sciatic nerve was combined with subcutaneous microdialysis of the hind paw. Following unilateral stimulation of the sciatic nerve, an ipsilateral rise in substance P and a bilateral rise
Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease.: Blood. 1995 Dec 15;86(12):4422-9. Unique Identifier : AIDSLINE MED/96127785; Pan L; Delmonte J Jr; Jalonen CK; Ferrara JL; Division of Pediatric Oncology, Dana Farber Cancer Institute,; Boston, MA 02115, USA.; The incidence and severity of acute graft-versus-host disease (GVHD) after allogeneic transplantation using peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) appear to be no worse than those after bone marrow transplantation, despite the presence of large numbers of T cells i
Role of zidovudine antiretroviral therapy in the pathogenesis of acquired immunodeficiency syndrome-related lymphoma.: Blood. 1995 Dec 15;86(12):4612-6. Unique Identifier : AIDSLINE MED/96127807; Levine AM; Bernstein L; Sullivan-Halley J; Shibata D; Mahterian SB; Nathwani BN; Department of Internal Medicine, University of Southern; California, School of Medicine, Los Angeles 90033, USA.; The role of zidovudine and other antiretroviral agents in the pathogenesis of acquired immunodeficiency syndrome (AIDS)-related lymphomas has been somewhat controversial. In an attempt to elucidate the precise role of antiretroviral agents in the subsequent development of AIDS-related lymphoma, we performed a populati
Presence of Epstein-Barr virus viral interleukin-10 in the serum of patients with non-human-immunodeficiency-virus-related diffuse large-cell non-Hodgkin's lymphomas [letter]: Blood. 1995 Dec 15;86(12):4702-4. Unique Identifier : AIDSLINE MED/96127821; Blay JY; Voorzanger N; Favrot M; Burdin N; Rousset F; Banchereau J
HIV risk: no impact on medical student specialty choice.: R I Med. 1995 Oct;78(10):293-4. Unique Identifier : AIDSLINE MED/96108144; Gady J; Boyan S; Jayaraman M; Kelly M; Kobayashi L; Lee P; Lynch T; Minter M; Spooner AM; Taylor J; et al; Brown University School of Medicine, USA.
AIDS clinic at the ACI.: R I Med. 1995 Oct;78(10):296-7. Unique Identifier : AIDSLINE MED/96108146; Khawaja M
Re-evaluation of skin-explant model in graft-versus-host disease prediction.: Clin Transplant. 1995 Oct;9(5):370-4. Unique Identifier : AIDSLINE MED/96081141; Sahin S; Akoglu TF; Gurbuz O; Ergun T; Kullu S; Sav A; Ahiskali R; Tuzuner N; Dogusoy G; Department of Hematology and Immunology, Marmara University; Medical School, Istanbul, Turkiye.; An in vitro skin explant model has been proposed for prediction of graft versus host disease and reported to be highly sensitive and specific for this purpose. In this study we have re-evaluated this model in both HLA full-matched BMT recipient-donor sibling pairs and also in HLA one haplotype-matched parent-children
A new nucleophilic ring opening of an activated cyclopropane and a formal synthesis of (+/-)-carbovir.: Biosci Biotechnol Biochem. 1995 Nov;59(11):2091-3. Unique Identifier : AIDSLINE MED/96100939; Tanimori S; Tsubota M; He M; Nakayama M; Department of Applied Biochemistry, College of Agriculture, Osaka; Prefecture University, Japan.; The reaction of bicyclo[3.1.0]hexane 1, possessing a doubly activated cyclopropane ring, with acetic acid and potassium acetate in DMSO proceeded smoothly to give the adduct 2 in good yield. A formal total synthesis of the potent anti-HIV agent (+/-)-carbovir (9) was done by converting 2 into a known precursor 8 in 8
'Soundex' codes of surnames provide confidentiality and accuracy in a national HIV database.: Commun Dis Rep CDR Rev. 1995 Nov 10;5(12):R183-6. Unique Identifier : AIDSLINE MED/96102412; Mortimer JY; Salathiel JA; PHLS AIDS Centre.; Clinicians and microbiologists will participate in voluntary national reporting of HIV infections and AIDS only if they have confidence in the scheme s confidentiality. At the same time, if the data are to be accurate, it must be possible to recognise reports that refer to the same individual. The use of surname soun
Primary care of children with HIV infection.: Curr Opin Pediatr. 1995 Oct;7(5):502-12. Unique Identifier : AIDSLINE MED/96120874; Forsyth BW; Yale University School of Medicine, Department of Pediatrics, New; Haven, CT 06510-8064, USA.; As the number of children affected by the HIV epidemic increases, the primary care physician can have an important role in ensuring that these children receive comprehensive health care. Clinical aspects of pediatric HIV disease are reviewed, including the recently revised Centers for Disease Control and Prevention cl
Chronic hepatitis in children.: Curr Opin Pediatr. 1995 Oct;7(5):539-46. Unique Identifier : AIDSLINE MED/96120879; Maggiore G; Istituto di Clinica Pediatrica, Universita di Pisa, Italy.; Autoimmune hepatitis is an inflammatory disease of the liver of unknown etiology that progresses toward cirrhosis and liver failure and is generally responsive to immunosuppressive treatment. The presence of anti-smooth muscle antibodies with anti-actin specificity and of anti-liver kidney microsomal antibodies define
A statewide program to evaluate the quality of care provided to persons with HIV infection.: Jt Comm J Qual Improv. 1995 Sep;21(9):439-56. Unique Identifier : AIDSLINE MED/96098517; Agins BD; Young MT; Ellis WC; Burke GR; Rotunno FF; AIDS Institute, New York State Department of Health, USA.
Sexually transmitted diseases, human immunodeficiency virus, and pregnancy prevention. Combined contraceptive practices among urban African-American early adolescents.: Arch Pediatr Adolesc Med. 1996 Jan;150(1):17-24. Unique Identifier : AIDSLINE MED/96133233; Stanton BF; Li X; Galbraith J; Feigelman S; Kaljee L; Department of Pediatrics, University of Maryland, Baltimore, USA.; OBJECTIVE: To evaluate the success of efforts to educate youth not only to use prescription contraceptives to avoid pregnancy, but also to use condoms to avoid sexually transmitted diseases, including infection with the human immunodeficiency virus. METHODS: Longitudinal study of 383 African-American youth aged 9 to 1
Trends and predictors of human immunodeficiency virus antibody testing by homosexual and bisexual adolescent males, 1989-1994.: Arch Pediatr Adolesc Med. 1996 Jan;150(1):33-8. Unique Identifier : AIDSLINE MED/96133235; Povinelli M; Remafedi G; Tao G; Mayo Medical School, Rochester, Minn, USA.; OBJECTIVE: To identify temporal trends and predictors of human immunodeficiency virus (HIV) antibody testing in homosexual and bisexual youth, using the Health Belief Model as a conceptual framework. DESIGN: Cross-sectional survey. SUBJECTS: Five hundred one male volunteers, 13 to 21 years old, self-identified as homo
In search of the Holy Grail [editorial; comment]: Arch Pediatr Adolesc Med. 1996 Jan;150(1):39. Unique Identifier : AIDSLINE MED/96133236; Oleske JM
Diagnosis of pediatric human immunodeficiency virus infection by means of a commercially available polymerase chain reaction gene amplification [see comments]: Arch Pediatr Adolesc Med. 1996 Jan;150(1):40-5. Unique Identifier : AIDSLINE MED/96133237; Nelson RP Jr; Price LJ; Halsey AB; Graven SN; Resnick L; Day NK; Lockey RF; Good RA; Department of Pediatrics, University of South Florida College of; Medicine, St Petersburg, USA.; OBJECTIVE: To assess the sensitivity and specificity of polymerase chain reaction (PCR) in infants and children at risk for human immunodeficiency virus (HIV) infection. DESIGN: A prospective, blinded study of 286 HIV-seropositive infants and children. Infection was diagnosed by antibody detection after 18 months of a
Outcome of MDR-TB patients, 1983-1993. Prolonged survival with appropriate therapy.: Am J Respir Crit Care Med. 1996 Jan;153(1):317-24. Unique Identifier : AIDSLINE MED/96134240; Park MM; Davis AL; Schluger NW; Cohen H; Rom WN; Department of Medicine, New York University Medical Center, New; York, USA.; We analyzed the clinical and laboratory findings and outcome of 173 patients hospitalized at our institution from 1983 to 1994 with multidrug-resistant tuberculosis (MDR-TB) and evaluated outcome. The 173 patients (mean age 40 +/- 1 yr) were predominantly male (92%), African American or Hispanic (80%), and mostly undo
Transmission of tuberculosis to close contacts of patients with multidrug-resistant tuberculosis.: Am J Respir Crit Care Med. 1996 Jan;153(1):331-5. Unique Identifier : AIDSLINE MED/96134242; Kritski AL; Marques MJ; Rabahi MF; Vieira MA; Werneck-Barroso E; Carvalho CE; Andrade G de N; Bravo-de-Souza R; Andrade LM; Gontijo PP; Riley LW; Servico de Pneumologia, Hospital Clementino Fraga Filho,; Universidade Federal de Rio de Janeiro, Brazil.; Multidrug-resistant tuberculosis (MDRTB) has emerged as a major public health problem worldwide. To determine the incidence and risk factors associated with tuberculosis among contacts of MDRTB index cases, we studied human immunodeficiency virus-seronegative close contacts of 64 culture-confirmed MDRTB patients in Ri
Sex and travel.: Br J Hosp Med. 1995 Sep 20-Oct 3;54(6):264-6, 275. Unique Identifier : AIDSLINE MED/96111107; Mabey D; London School of Hygiene and Tropical Medicine.; Sexually transmitted diseases have been associated with travellers since they were first described. The scale of international travel has increased enormously in the past 50 years, enabling sexually transmitted pathogens to spread with unprecedented speed. This article assesses the importance of international travel a
[The clinical characteristics of pleural tuberculosis in patients with and without human immunodeficiency virus infection]: Arch Bronconeumol. 1995 Dec;31(10):512-8. Unique Identifier : AIDSLINE MED/96136389; Cordero PJ; Gil Suay V; Greses JV; Soler JJ; Perpina M; Sanchis F; Sanchis J; Servicio de Neumologia, Hospital Universitario La Fe, Valencia.; OBJECTIVE: To determine whether or not there are differences in the characteristics of pleural tuberculosis (PT) related to whether patients are or are not infected by human immunodeficiency virus (HIV). METHODS: We conducted a retrospective study of the medical histories of patients diagnosed of PT in our hospital be
Target DNA capture by HIV-1 integration complexes.: Curr Biol. 1995 Sep 1;5(9):1047-56. Unique Identifier : AIDSLINE MED/96076268; Miller MD; Bor YC; Bushman F; Infectious Disease Laboratory, Salk Institute for Biological; Studies, La Jolla, California 92024, USA.; BACKGROUND: The early steps of human immunodeficiency virus 1 (HIV-1) replication involve reverse transcription of the viral RNA and integration of the resulting cDNA into a host chromosome. The DNA integration step requires the integration machinery ( preintegration complex ) to bind to the host DNA before connecting
[In the name of Commission VII (Sexually transmissible diseases and AIDS). Heterosexual transmission of HIV in France]: Bull Acad Natl Med. 1995 Jun;179(6):1209-24. Unique Identifier : AIDSLINE MED/96092146; Montagnier L
Synthesis of curdlan sulfates having inhibitory effects in vitro against AIDS viruses HIV-1 and HIV-2.: Carbohydr Res. 1995 Oct 23;276(2):425-36. Unique Identifier : AIDSLINE MED/96073117; Yoshida T; Yasuda Y; Mimura T; Kaneko Y; Nakashima H; Yamamoto N; Uryu T; Division of Biological Sciences, Graduate School of Science,; Hokkaido University, Sapporo, Japan.
[Cruciate ligament allograft transplant: a reliable alternative?]: Chirurg. 1995 Nov;66(11):1071-8. Unique Identifier : AIDSLINE MED/96109535; Lobenhoffer P; Lattermann C; Unfallchirurgische Klinik, Medizinischen Hochschule Hannover.
A highly sensitive polymerase chain reaction method reveals the ubiquitous presence of maternal cells in human umbilical cord blood.: Exp Hematol. 1995 Dec;23(14):1601-5. Unique Identifier : AIDSLINE MED/96130296; Petit T; Gluckman E; Carosella E; Brossard Y; Brison O; Socie G; Laboratoire de Genetique Oncologique, URA 1967 CNRS, Institut; Gustave Roussy, Villejuif, France.; Umbilical cord blood is considered an alternate source of hematopoietic stem cells in bone marrow transplantation. However, its use might be hampered by contamination of neonatal blood with maternal cells, which could contribute unacceptably to graft-vs.-host disease (GVHD) after transplant. In a previous study (Socie
The Gag polypeptides of the Drosophila 1731 retrotransposon are associated to virus-like particles and to nuclei.: FEBS Lett. 1995 Dec 11;377(1):67-72. Unique Identifier : AIDSLINE MED/96130323; Haoudi A; Kim MH; Champion S; Best-Belpomme M; Maisonhaute C; Laboratoire de Genetique Cellulaire et Moleculaire, UA 1135 CNRS,; Universite Pierre and Marie Curie, Paris, France.; 1731 is a Drosophila melanogaster retrotransposon whose nucleotide sequence shows a proviral architecture with two long terminal repeats (LTRs) framing two internal Open Reading Frames (ORFs). The pol ORF2 of this mobile genetic element was demonstrated to code for an active Reverse Transcriptase (RT) and the ORF1 is
Epitope mapping of anti-HIV and anti-HCV monoclonal antibodies and characterization of epitope mimics using a filamentous phage peptide library.: Gene. 1995 Dec 12;166(2):187-95. Unique Identifier : AIDSLINE GENBANK/L39948; Grihalde ND; Chen YC; Golden A; Gubbins E; Mandecki W; Aging and Degenerative Disease Department, Abbott Laboratories,; North Chicago, IL 60064, USA.; A large filamentous phage library (1 x 10(9) clones) displaying random 30-amino-acid (aa) sequences on the N terminus of the pIII coat protein was constructed and characterized. Clones in the library were affinity selected for binding to monoclonal antibodies (mAb) against two viral antigens, the HIV gp120 protein and
Antiviral activity and protection of cells against human immunodeficiency virus type-1 using an antisense oligodeoxyribonucleotide phosphorothioate complementary to the 5'-LTR region of the viral genome.: Gene. 1995 Dec 12;166(2):227-32. Unique Identifier : AIDSLINE MED/96125194; Anazodo MI; Salomon H; Friesen AD; Wainberg MA; Wright JA; Manitoba Institute of Cell Biology, University of Manitoba,; Winnipeg, Canada.; A COS-like monkey kidney cell line stably transfected with the plasmids pCMVgagpol-rre-r with the gag and pol genes, and pCMV rev with the rev gene of HIV-1 derived from the cDNA clone BH10, was used as a model for assessing the effectiveness of antisense (AS) constructs, A 20-mer oligodeoxyribonucleotide (oligo) phos
[Zidovudine therapy alone is not enough (news)]: Fortschr Med. 1995 Nov 20;113(32):13-4. Unique Identifier : AIDSLINE MED/96109998
[AIDS vaccine: who should be selected for the test?]: Fortschr Med. 1995 Nov 20;113(32):16-7. Unique Identifier : AIDSLINE MED/96109999; Marcus U; AIDS-Zentrum im Robert-Koch-Institut, Berlin.
Selective inhibitory effects of stress hormones on natural killer (NK) cell activity of lymphocytes from AIDS patients.: Immunol Invest. 1995 Aug;24(5):689-99. Unique Identifier : AIDSLINE MED/96051528; Nair MP; Saravolatz LD; Schwartz SA; Department of Medicine and Microbiology, State University of New; York at Buffalo, Buffalo General Hospital 14203, USA.; To examine the potential role of stress hormones in the progression of HIV infections, we developed an in vitro model system that investigates the effects of cortisol, adrenocorticotropin-releasing hormone (ACTH) and beta-endorphin on the natural killer cell activity of lymphocytes from normal subjects and AIDS patien
Utilization of used human immunodeficiency virus ELISA microplates & surplus reagents for HIV antibody testing.: Indian J Med Res. 1995 Oct;102:159-61. Unique Identifier : AIDSLINE MED/96108007; Makhija SK; Dhanvijay AG; Pathak AA; Saoji AM; AIDS Surveillance Centre & Regional STD Reference Centre,; Department of Microbiology, Government Medical College &; Hospital, Nagpur.; Used non-competitive enzyme-linked immunosorbent assay (ELISA) microplates were washed and reused to test samples and positive and negative controls, utilising the surplus reagents provided with the kit, which otherwise would have been discarded as useless after the entire 960 test kit had been utilized. These surplus
Preferred nucleotide sequence at the integration target site of human T-cell leukemia virus type I from patients with adult T-cell leukemia.: Int J Cancer. 1996 Jan 3;65(1):20-4. Unique Identifier : AIDSLINE MED/96125762; Chou KS; Okayama A; Su IJ; Lee TH; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115, USA.; Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). We cloned and sequenced host DNA adjacent to the long terminal repeats of HTLV-I from uncultured leukemic cells of 4 ATL patients. The region flanking the provirus was generally A/T-rich (60-64% A/T), and
Herpesvirus-like DNA sequences detected in endemic, classic, iatrogenic and epidemic Kaposi's sarcoma (KS) biopsies.: Int J Cancer. 1996 Jan 3;65(1):25-8. Unique Identifier : AIDSLINE MED/96125763; Buonaguro FM; Tornesello ML; Beth-Giraldo E; Hatzakis A; Mueller N; Downing R; Biryamwaho B; Sempala SD; Giraldo G; Istituto Nazionale Tumori Fond. Pascale, Naples, Italy.; The identification of Kaposi s sarcoma (KS) clusters in sub-equatorial Africa (endemic KS, AKS) and the high frequency of KS in sexually transmitted AIDS (epidemic KS, EKS), have previously suggested a role for infectious agents in the etiopathogenesis of KS. The recent identification of herpesvirus (HHV)-like DNA seq
Oral candidosis.: Int J Dermatol. 1995 Nov;34(11):759-65. Unique Identifier : AIDSLINE MED/96128694; Mooney MA; Thomas I; Sirois D; Dermatology Department, UMDNJ-New Jersey Medical School, Newark; 07103, USA.
Immunohistochemistry in histoid leprosy.: Int J Dermatol. 1995 Nov;34(11):777-81. Unique Identifier : AIDSLINE MED/96128698; Kontochristopoulos GJ; Aroni K; Panteleos DN; Tosca AD; Hansen's Disease Center, General Hospital of Western Attica,; Athens, Greece.; BACKGROUND. Histoid leprosy is a rare form of multibacillary leprosy as the result of secondary or even primary resistance to dapsone. The etiopathogenesis has not been clarified up to now. METHODS. An immunohistochemical study was carried out for the expression of various markers on epidermal and dermal cell populati
Malignant hemangioendothelioma.: Int J Dermatol. 1995 Nov;34(11):811-6. Unique Identifier : AIDSLINE MED/96128708; Ihda H; Tokura Y; Fushimi M; Yokote R; Hashizume H; Shirahama S; Iwatsuki K; Murakami K; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; BACKGROUND. The administration of interleukin-2 ( IL-2 ) has recently been reported to be favorable for treating malignant hemangioendothelioma (MHE). METHODS. Two patients with MHE responded well to intralesional injections of recombinant IL-2 (rIL-2) without major side
[Young man with swelling of the left side of the neck and right testis]: Internist (Berl). 1995 Nov;36(11):1080-4. Unique Identifier : AIDSLINE MED/96091845; Jakob AR; Kuhl M; Wilmanns W; Schalhorn A; III. Medizinische Klinik, Klinikum Grosshadern,; Ludwig-Maximilians-Universitat Munchen.
Ribozymes: from mechanistic studies to applications in vivo.: J Biochem (Tokyo). 1995 Aug;118(2):251-8. Unique Identifier : AIDSLINE MED/96064140; Ohkawa J; Koguma T; Kohda T; Taira K; National Institute of Bioscience and Human Technology, Agency of; Industrial Science & Technology, MITI.; The hammerhead ribozyme belongs to the class of molecules known as antisense RNAs. However, because of short extra sequences that form the so-called catalytic loop, it can act as an enzyme. Since the catalytic domain captures magnesium ions and magnesium ions can cleave phosphodiester bonds, hammerhead ribozymes are r
Tissue diagnosis of intestinal microsporidiosis using a fluorescent stain with Uvitex 2B.: J Clin Pathol. 1995 Nov;48(11):1009-10. Unique Identifier : AIDSLINE MED/96138182; Franzen C; Muller A; Salzberger B; Fatkenheuer G; Eidt S; Mahrle G; Diehl V; Schrappe M; Department of Internal Medicine I, University of Cologne,; Germany.; AIMS--To detect intestinal microsporidiosis in paraffin wax embedded biopsy specimens using a fluorescence technique incorporating optical brighteners. METHODS--Eight HIV infected patients with confirmed intestinal microsporidiosis (six with Enterocytozoon bieneusi, on
Clinical and histopathologic features of hair loss in patients with HIV-1 infection.: J Am Acad Dermatol. 1996 Jan;34(1):63-8. Unique Identifier : AIDSLINE MED/96140324; Smith KJ; Skelton HG; DeRusso D; Sperling L; Yeager J; Wagner KF; Angritt P; United States Army Medical Research Institute for Chemical; Defense, Aberdeen, Maryland, USA.; BACKGROUND: Hair loss is common in patients with HIV-1 infection, and in black patients this loss may be associated with straightening. Possible causes are frequently present in patients with HIV-1. These causes include chronic HIV-1 infection itself and recurrent secondary infections, nutritional deficiencies, immuno
Clinical and histologic spectrum of human T-cell lymphotropic virus type I-associated lymphoma involving the skin.: J Am Acad Dermatol. 1996 Jan;34(1):69-76. Unique Identifier : AIDSLINE MED/96140325; DiCaudo DJ; Perniciaro C; Worrell JT; White JW Jr; Cockerell CJ; Department of Dermatology, Mayo Clinic, Rochester, Minnesota,; USA.; BACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is associated with infection with human T-cell lymphotropic virus type I (HTLV-I). OBJECTIVE: The objective was to describe the clinical, histopathologic, and immunologic features in three patients with ATL involving the skin. METHODS: Clinical histories and skin biopsy
Increased attention to human sexuality can improve HIV-AIDS prevention efforts: key research issues and directions.: J Consult Clin Psychol. 1995 Dec;63(6):907-18. Unique Identifier : AIDSLINE MED/96116559; Kelly JA; Kalichman SC; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226, USA.; Curtailing the human immunodeficiency virus (HIV) epidemic requires the development of effective strategies for helping people reduce high-risk sexual behavior patterns. Because the objective of HIV prevention involves changing how people behave sexually, research findings in human sexuality are extremely pertinent to
Resolution of chronic urticaria in patients with thyroid autoimmunity.: J Allergy Clin Immunol. 1995 Dec;96(6 Pt 1):901-5. Unique Identifier : AIDSLINE MED/96133469; Rumbyrt JS; Katz JL; Schocket AL; National Jewish Center for Immunology and Respiratory Disease,; Denver, CO, USA.; BACKGROUND: Autoimmune disease has been implicated as a cause of chronic urticaria, and anti-thyroid antibodies have been found in patients with chronic urticaria. Because some patients with chronic urticaria and autoimmune hypothyroidism have had clinical resolution with thyroid hormone replacement, we investigated t
Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene.: J Immunol. 1996 Jan 15;156(2):424-9. Unique Identifier : AIDSLINE MED/96132964; Song Z; Casolaro V; Chen R; Georas SN; Monos D; Ono SJ; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21224, USA.; Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated total serum IgE levels and is thought to be controlled by a major susceptibility gene and multiple minor susceptibility genes. A recent sib-pair analysis revealed
Structure and expression of murine CD30 and its role in cytokine production.: J Immunol. 1996 Jan 15;156(2):442-9. Unique Identifier : AIDSLINE GENBANK/U25416; Bowen MA; Lee RK; Miragliotta G; Nam SY; Podack ER; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; WA 98121, USA.; Murine CD30 cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family of proteins characterized by repeated cysteine-rich motifs in the extracellular domain. Murine CD30, although homologous to human CD30, has a 90 amino acid gap in an extracellular region that appears to be duplicated in hum
IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2.: J Immunol. 1996 Jan 15;156(2):515-22. Unique Identifier : AIDSLINE GENBANK/L14680; Mor F; Cohen IR; Department of Immunology, Weizmann Institute of Science, Rehovot,; Israel.; Most studies of apoptosis on T lymphocytes have examined the effects of various stimuli on immature T cells from the thymus. Previous work has indicated that apoptosis of mature memory T cells may be an important pathophysiologic mechanism in diseases such as AIDS, cancer, and autoimmunity. The effect of
Down-regulation of T lymphocyte activation in vitro and in vivo induced by glycoinositolphospholipids from Trypanosoma cruzi. Assignment of the T cell-suppressive determinant to the ceramide domain.: J Immunol. 1996 Jan 15;156(2):628-35. Unique Identifier : AIDSLINE MED/96132989; Gomes NA; Previato JO; Zingales B; Mendonca-Previato L; DosReis GA; Institute of Microbiology, Federal University of Rio de Janeiro,; Brazil.; The major surface glycoinositolphospholipid (GIPL) from Trypanosoma cruzi was purified and assessed in mouse T cell function assays. Purified GIPLs from T. cruzi strains Y and G, but not from a plant trypanosomatid (Phytomonas serpens), markedly blocked in vitro CD4+ and CD8+ T cell mitogenesis induced by bacterial su
Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.: J Immunol. 1996 Jan 15;156(2):636-43. Unique Identifier : AIDSLINE MED/96132990; Khan IA; Matsuura T; Fonseka S; Kasper LH; Department of Medicine, Dartmouth Medical School, Hanover, NH; 03755, USA.; Production of nitric oxide (NO) by macrophages is important for the killing of intracellular pathogens. IFN-gamma and LPS stimulate NO production by transcriptional up-regulation of inducible nitric oxide synthetase (iNOS). In the present study we used mice with a targeted disruption of the IFN regulatory factor-1 gen
Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-gamma response and increased production of T helper 2 cytokines.: J Immunol. 1996 Jan 15;156(2):644-52. Unique Identifier : AIDSLINE MED/96132991; Krishnan L; Guilbert LJ; Russell AS; Wegmann TG; Mosmann TR; Belosevic M; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; Resolution of cutaneous leishmaniasis in infected mice is associated with a polarized Th1 immune response by the host, whereas maternal immune responses during pregnancy appear to be biased toward humoral (Th2) and away from cell-mediated (Th1) responses. The objective of this study was to evaluate whether the putativ
T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.: J Immunol. 1996 Jan 15;156(2):653-62. Unique Identifier : AIDSLINE MED/96132992; Krishnan L; Guilbert LJ; Wegmann TG; Belosevic M; Mosmann TR; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada.; Maternal immune responses can influence fetal survival and several cytokines have harmful or protective effects on pregnancy. The Th1 cytokines IFN-gamma and IL-2 can cause fetal loss, whereas the Th2 cytokine IL-10 is protective. However, infections such as leishmania
Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential.: J Immunol. 1996 Jan 15;156(2):670-8. Unique Identifier : AIDSLINE MED/96132994; Rawadi G; Roman-Roman S; Castedo M; Dutilleul V; Susin S; Marchetti P; Geuskens M; Kroemer G; Roussel Uclaf, Domaine Therapeutique Immunologie, Romainville,; France.; Mycoplasma fermentans is a mycoplasma species that has been accused of serving as a cofactor of AIDS development. Here, we show that M. fermentans affects the function of human monocytes and myelomonocytic cell lines on at least two different levels. Heat-inactivated mycoplasma particles induce inflammatory cytokines
CD4-imitating human antibodies in HIV infection and anti-idiotypic vaccination.: J Immunol. 1996 Jan 15;156(2):826-33. Unique Identifier : AIDSLINE MED/96133014; Deckert PM; Ballmaier M; Lang S; Deicher H; Schedel I; Division of Clinical Immunology, Hannover Medical School,; Germany.; Anti-idiotypic vaccination against HIV infection aims at inducing an anti-gp120 immune response through anti-CD4 Abs mimicking epitopes of the gp120 molecule. The mAb IOT4a induces anti-gp120 Abs in rabbits. This study investigates the presence of human serum Abs cross-reacting with anti-CD4 mAbs and gp120 during HIV
Class I-restricted presentation of an HIV-1 gp41 epitope containing an N-linked glycosylation site. Implications for the mechanism of processing of viral envelope proteins.: J Immunol. 1996 Jan 15;156(2):834-40. Unique Identifier : AIDSLINE MED/96133015; Ferris RL; Buck C; Hammond SA; Woods AS; Cotter RJ; Takiguchi M; Igarashi Y; Ichikawa Y; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; Uncertainty exists over the site of processing of viral envelope (env) proteins for recognition by CTL. The extracellular domains of env proteins are not present in the cytosol, the site where the class I Ag processing pathway begins. Rather, the ecto-domains of env proteins are cotranslationally translocated into the
IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.: J Immunol. 1996 Jan 15;156(2):841-51. Unique Identifier : AIDSLINE MED/96133016; Finnegan A; Roebuck KA; Nakai BE; Gu DS; Rabbi MF; Song S; Landay AL; Department of Medicine, Rush-Presbyterian-St. Luke's Medical; Center, Chicago, IL 60612, USA.; IL-10 is elevated in HIV-1-infected individuals and has been implicated in disease progression. In this study, we investigated the effects of IL-10 on the activation of HIV-1 from infected monocytes and macrophages. Although IL-10 alone did not induce HIV-1 replication, in the presence of TNF-alpha, IL-10 markedly enh
An antibody that binds domain 1 of CD4 inhibits replication of HIV-1, but not HTLV-I, in a CD4-positive/p56lck-negative HTLV-I-transformed cell line.: J Immunol. 1996 Jan 15;156(2):859-65. Unique Identifier : AIDSLINE MED/96133018; Lemasson I; Briant L; Hague B; Coudronniere N; Heron L; David C; Rebouissou C; Kindt T; Devaux C; Laboratory of Immunology for Retroviral Infections, INSERM U249,; Institute of Biology, Montpellier, France.; mAbs that bind to the Ig CDR3-like region in D1 domain of the CD4 molecule can inhibit the HIV-1 life cycle in CD4-positive T cells and lymphoblastoid cell lines at the stage of transcription. This antiviral effect requires the integrity of the cytoplasmic tail of CD4, which acts as a signal transduction region throug
Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24.: J Immunol. 1996 Jan 15;156(2):873-9. Unique Identifier : AIDSLINE MED/96133020; Suzue K; Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142,; USA.; Heat shock proteins are major targets of the immune response to bacterial and parasitic pathogens. Mycobacterium tuberculosis hsp70 is an especially powerful Ag containing multiple B and T cell epitopes. We investigated whether M. tuberculosis hsp70 can be used as an adjuvant-free carrier to stimulate the humoral and
Neurophysiological evaluation of zidovudine in asymptomatic HIV-1 infection: a longitudinal placebo-controlled study.: J Neurol Sci. 1995 Oct;132(2):162-9. Unique Identifier : AIDSLINE MED/96098605; Baldeweg T; Riccio M; Gruzelier J; Hawkins D; Burgess A; Irving G; Stygall J; Catt S; Catalan J; Academic Department of Psychiatry, Charing Cross and Westminster; Medical School, London, UK.; The effect of early antiretroviral medication with zidovudine on neurophysiological functions was evaluated in subjects with asymptomatic HIV-1 infection. Patients were recruited participants of a larger double-blind randomised placebo-controlled treatment trial with zidovudine (Concorde). The main outcome measures in
A follow-up study on spastic paraparesis in Japanese HAM/TSP.: J Neurol Sci. 1995 Oct;132(2):174-6. Unique Identifier : AIDSLINE MED/96098607; Kuroda Y; Yukitake M; Kurohara K; Takashima H; Matsui M; Department of Internal Medicine, Saga Medical School, Japan.; We followed 24 patients with HTLV-I-associated myelopathy (HAM) for 4-12 years (mean 7 years) and assessed longitudinal changes of their spastic paraparesis by Kurtzke s Disability Status Scale (DSS). The DSS score of spastic paraparesis was unchanged in 18 patients (75%), advanced (worsened) by two in 1 patient and b
Mediation of immunity to Toxoplasma gondii oocyst shedding in cats.: J Parasitol. 1995 Dec;81(6):882-6. Unique Identifier : AIDSLINE MED/96130073; Davis SW; Dubey JP; Parasite Biology and Epidemiology Laboratory, Agricultural; Research Service, United States Department of Agriculture,; Beltsville, Maryland 20705-2350, USA.; Immunity to Toxoplasma gondii, as measured by oocyst shedding, was studied in cats. In 3 trials, 12 3-mo-old T. gondii-free cats were fed tissue cysts of the ME-49 strain of T. gondii. All cats shed T. gondii oocysts for approximately 1 wk starting 3-5 days after ingesting tissue cysts. One cat became ill because of t
Preimmune resistance to Toxoplasma gondii in aged and young adult mice.: J Parasitol. 1995 Dec;81(6):894-9. Unique Identifier : AIDSLINE MED/96130075; Johnson LL; Gibson GW; Sayles PC; Trudeau Institute, Inc., Saranac Lake, New York 12983, USA.; Aged individuals are more susceptible to certain infections than are young adults. To investigate the relative resistance capabilities of aged and young adult mice, responses that are induced within the first week of a Toxoplasma gondii infection, which are known to be involved in preimmune resistance, were compared i
Risk factors for HIV infection overlooked in routine antenatal care.: J R Soc Med. 1995 Nov;88(11):634-6. Unique Identifier : AIDSLINE MED/96138230; Hawken J; Chard T; Costeloe K; Jeffries DJ; Hudson CN; Department of Obstetrics & Gynaecology, Medical College of St; Bartholomew's Hospital, London, England.; We have ascertained the extent to which risk factors for HIV infection may escape detection by standard history-taking procedures in an antenatal clinic. This study was based on 1264 women from a multi-ethnic population in an inner London health district (City and Hackney). All had agreed to undergo attributable HIV t
Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors.: J Med Chem. 1995 Dec 22;38(26):4968-71. Unique Identifier : AIDSLINE MED/96130342; Skulnick HI; Johnson PD; Howe WJ; Tomich PK; Chong KT; Watenpaugh KD; Janakiraman MN; Dolak LA; McGrath JP; Lynn JC; et al; Upjohn Laboratories, Kalamazoo, Michigan 49001, USA.
Tuberculosis into the next century. Proceedings of a symposium held on 4 February 1995 at the Liverpool School of Medicine.: J Med Microbiol. 1996 Jan;44(1):1-34. Unique Identifier : AIDSLINE MED/96149189
From the Food and Drug Administration.: JAMA. 1996 Jan 24-31;275(4):273. Unique Identifier : AIDSLINE MED/96144522; Nightingale SL; Office of Health Affairs, FDA, Rockville, MD 20857, USA.
From the Centers for Disease Control and Prevention. Case-control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV-infected blood--France, United Kingdom, and United States, January 1988-August 1994.: JAMA. 1996 Jan 24-31;275(4):274-5. Unique Identifier : AIDSLINE MED/96144523
Transmission of tuberculosis among the urban homeless.: JAMA. 1996 Jan 24-31;275(4):305-7. Unique Identifier : AIDSLINE MED/96144538; Barnes PF; el-Hajj H; Preston-Martin S; Cave MD; Jones BE; Otaya M; Pogoda J; Eisenach KD; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033, USA.; OBJECTIVE--To determine the relative frequencies of primary and reactivation tuberculosis in the urban homeless. DESIGN--Prospective evaluation of homeless tuberculosis patients. SETTING--Central Los Angeles, Calif. PATIENTS--Thirty-four homeless patients with culture-proven tuberculosis. INTERVENTIONS--IS6110-based r
Reporting HIV infection in children: physician practices and perceptions.: J S C Med Assoc. 1995 Nov;91(11):451-5. Unique Identifier : AIDSLINE MED/96108045; Meyer PA; Jones JL; Breeden DC; Garrison CZ; South Carolina Department of Environmental Control, University of; South Carolina, Columbia 29208, USA.
Extrapulmonary tuberculosis in Tennessee: lessons from the last decade.: J Tenn Med Assoc. 1996 Jan;89(1):8-12. Unique Identifier : AIDSLINE MED/96137547; Roy TM; Mehta JB; Harvill LM; Division of Pulmonary Medicine, James H. Quillen College of; Medicine, East Tennessee State University, Johnson City; 37614-0622, USA.; In conclusion, extrapulmonary TB remains a significant fraction of the total TB cases in Tennessee. During the last few years, the percentage of extrapulmonary TB in Tennessee has been on the increase. Understanding these changes in the epidemiology of extrapulmonary TB will help the clinician in making a prompt diagn
[Safety of plasma products may be improved (letter)]: Lakartidningen. 1995 Dec 20;92(51-52):4869-70. Unique Identifier : AIDSLINE MED/96141503; Wahlberg T
Was HIV present in 1959? [letter]: Lancet. 1996 Jan 20;347(8995):189. Unique Identifier : AIDSLINE MED/96138291; Bailey AS; Corbitt G
Porphyria cutanea tarda preceding AIDS [letter]: Lancet. 1996 Jan 20;347(8995):190. Unique Identifier : AIDSLINE MED/96138292; Ash S; Woodley DT; Chan LS
HIV transmission by donor semen [letter]: Lancet. 1996 Jan 20;347(8995):190-1. Unique Identifier : AIDSLINE MED/96138293; Papadopulos-Eleopulos E; Turner VF; Causer DS; Papdimitriou JM
Hepatitis C virus infection in Italian intravenous drug users: epidemiological and clinical aspects.: Liver. 1995 Aug;15(4):209-12. Unique Identifier : AIDSLINE MED/96064257; Galeazzi B; Tufano A; Barbierato E; Bortolotti F; Servizio Tossicodipendenze (Ser.T.), Bassano Hospital, Italy.; The epidemological and clinical features of hepatitis C virus infection have been evaluated in a cohort of 227 intravenous drug users enrolled at a drug dependence treatment center in the Veneto area in 1992-1993 and followed periodically. Hepatitis C virus infection was detected using second-generation anti-HCV ELISA
Short echo time proton spectroscopy of the brain in HIV infection/AIDS.: Magn Reson Imaging. 1995;13(6):871-5. Unique Identifier : AIDSLINE MED/96122886; Paley M; Wilkinson ID; Hall-Craggs MA; Chong WK; Chinn RJ; Harrison MJ; MRI Unit, Middlesex Hospital, University College London; Hospitals, UK.; Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mi
Threshold analysis and programs for prevention of HIV infection.: Med Decis Making. 1995 Oct-Dec;15(4):311-7. Unique Identifier : AIDSLINE MED/96116981; Holtgrave DR; Qualls NL; Office of HIV/AIDS, Centers for Disease Control and Prevention; (CDC), Atlanta, Georgia, USA.; BACKGROUND. Measuring the economic effectiveness of HIV-infection prevention activities poses special challenges in terms of behavioral change and health outcomes assessment. METHODS. One way to address this difficulty is to employ threshold analysis to determine a level of cost per HIV infection averted above which s
Sera from HIV-1 infected individuals in all stages of disease preferentially recognize the V3 loop of the prototypic macrophage-tropic glycoprotein gp120 ADA.: Mol Immunol. 1995 Oct;32(14-15):1039-45. Unique Identifier : AIDSLINE MED/96128272; Ebenbichler C; McNearney T; Stoiber H; Most J; Zangerle R; Vogetseder W; Patsch JR; Ratner L; Dierich MP; Institut fur Hygiene und Ludwig-Boltzmann-Institut fur; AIDS-Forschung, Innsbruck, Austria.; The outer membrane glycoprotein gp120 and the transmembrane glycoprotein gp41 are predominant targets of the humoral immune response to infection by human immunodeficiency virus type 1. The third hypervariable region (V3 loop) is the principal neutralizing domain and is the primary target of neutralizing antibodies di
Use of a novel mutagenesis strategy, optimized residue substitution, to decrease the off-rate of an anti-gp120 antibody.: Mol Immunol. 1995 Oct;32(14-15):1065-72. Unique Identifier : AIDSLINE MED/96128275; Lewis CM; Hollis GF; Mark GE 3rd; Tung JS; Ludmerer SW; Merck Research Laboratories, Rahway, NJ 07065, USA.; We have developed a novel strategy to decrease the antibody:antigen off-rate which we call optimized residue substitution. This strategy employs alanine substitution to first identify residues non-optimal for binding, as evidenced by a decrease in off-rate upon alanine replacement. These positions are then individuall
Characterization of the variable regions of a chimpanzee monoclonal antibody with potent neutralizing activity against HIV-1.: Mol Immunol. 1995 Oct;32(14-15):1081-92. Unique Identifier : AIDSLINE GENBANK/X59315; Vijh-Warrier S; Murphy E; Yokoyama I; Tilley SA; Public Health Research Institute, New York 10016, USA.; The variable (V) regions of C108G, a potent neutralizing chimpanzee mAb against a glycan-dependent epitope in the V2 region of HIV-1 gp120, have been characterized for reactivity with human VH and VK family-specific antisera, and their nucleotide sequences have been determined and analysed. To our knowledge, this is t
[Epidemiology of drug addiction in The Netherlands]: Ned Tijdschr Geneeskd. 1995 Dec 16;139(50):2614-8. Unique Identifier : AIDSLINE MED/96129863; van Limbeek J; Buster MC; van Brussel GH; Gemeentelijke Geneeskundige en Gezondheidsdienst (GG&GD), sector; Geestelijke Gezondheidszorg, Amsterdam.
[Infectious complications of drug addiction]: Ned Tijdschr Geneeskd. 1995 Dec 16;139(50):2618-22. Unique Identifier : AIDSLINE MED/96129864; de Marie S; Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Inwendige; Geneeskunde.
[Drug abusers and sexually transmissible disorders]: Ned Tijdschr Geneeskd. 1995 Dec 16;139(50):2626-9. Unique Identifier : AIDSLINE MED/96129866; van den Hoek JA; Gemeentelijke Geneeskundige en Gezondheidsdienst (GG&GD), sector; Volksgezondheid en Milieu, Amsterdam.
[Drug abuse in Amsterdam, a public health problem]: Ned Tijdschr Geneeskd. 1995 Dec 16;139(50):2635-9. Unique Identifier : AIDSLINE MED/96129869; van Brussel GH; Gemeentelijke Geneeskundige en Gezondheidsdienst (GG&GD), Bureau; Drugshulpverlening, Amsterdam.
Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.: Neurology. 1995 Dec;45(12 Suppl 8):S73-5. Unique Identifier : AIDSLINE MED/96136232; Whitley RJ; Department of Pediatrics, University of Alabama at Birmingham; 35233, USA.; Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zo
Professional liability.: N J Med. 1995 Dec;92(12):771-2. Unique Identifier : AIDSLINE MED/96137604
Early complications of abdominal and vaginal hysterectomy.: Obstet Gynecol Surv. 1995 Nov;50(11):795-805. Unique Identifier : AIDSLINE MED/96123954; Harris WJ; East Tennessee State University Quillan College of Medicine,; Johnson City, USA.; In 1982, the Collaborative Review of Sterilization (CREST) study was published, reviewing the complications accompanying and following both abdominal and vaginal hysterectomy. This review was undertaken to see how these rates have changed in the ensuing years. All large series of abdominal and vaginal hysterectomy com
Benefit of primary prophylaxis before 18 months of age in reducing the incidence of Pneumocystis carinii pneumonia and early death in a cohort of 112 human immunodeficiency virus-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group.: Pediatrics. 1996 Jan;97(1):59-64. Unique Identifier : AIDSLINE MED/96133793; Thea DM; Lambert G; Weedon J; Matheson PB; Abrams EJ; Bamji M; Straus WL; Thomas PA; Krasinski K; Heagarty M; Medical and Health Research Association, New York, USA.; OBJECTIVE. To determine the effectiveness of primary prophylaxis in preventing Pneumocystis carinii pneumonia (PCP) in children with perinatally acquired human immunodeficiency virus 1 (HIV-1) infection. METHODS. We conducted a retrospective analysis of a cohort of infants followed from birth at six metropolitan hospi
The development of healthcare services for drug misusers and prostitutes.: Postgrad Med J. 1995 Oct;71(840):593-7. Unique Identifier : AIDSLINE MED/96142723; Morrison CL; Ruben SM; Maryland Centre, Liverpool, UK.; With the advent of human immunodeficiency virus (HIV) and the increase of drug misuse in the UK, the Government wishes primary care to play a greater part in treating drug problems in the hope of preventing the spread of HIV. Drug misusers do not avail themselves of traditional services and many are not registered wit
Tuberculosis health education. Needs in homeless shelters.: Public Health Nurs. 1995 Dec;12(6):409-16. Unique Identifier : AIDSLINE MED/96137682; Kitazawa S; School Health Programs Dept., San Francisco Unified School; District, California 94115, USA.; Tuberculosis has reemerged as an important public health concern, particularly with the rise in multi-drug-resistant strains. The homeless are at increased risk for infection, for active disease, and for incomplete treatment. Public health authorities have recommended that tuberculosis health education materials be de
[Nonketotic hyperglycemic coma induced by somatostatin in an AIDS patient]: Presse Med. 1995 Oct 14;24(30):1389-90. Unique Identifier : AIDSLINE MED/96142384; Vandercam B; Hermans MP; Coumans P; Jacques D; Gala JL; Kolanowski J; Departement de Medecine interne, Cliniques Universitaires; Saint-Luc, Bruxelles, Belgique.; A 33-year-old woman with AIDS was treated with somatostatin (continuous infusion 6 mg/day) for intractable diarrhoea. Improvement was insufficient and the dose was increased to 12 mg/day 5 days later. Hyperosmolar non-ketotic coma occurred two days later (blood glucose 53 mmol/l, bicarbonate 8 mmol/l, pH of arterial b
[Seroprevalence of cytomegalovirus infection in human immunodeficiency virus infected subjects (letter)]: Presse Med. 1995 Oct 21;24(31):1445. Unique Identifier : AIDSLINE MED/96142404; Rey D; Droit C; Partisani M; Jacquemin C; Kempf G; Lang JM
[Absence of regular medical follow-up: main cause of pneumocystosis diagnosed in patients with HIV infection in France in 1992 (letter)]: Presse Med. 1995 Nov 11;24(34):1623. Unique Identifier : AIDSLINE MED/96142453; Pradier C; Demeulemeester R; Nadal JM; Bourdillon F; Delfraissy JF; Bez G
[Bacterial esophagitis in AIDS (letter)]: Presse Med. 1995 Nov 11;24(34):1624. Unique Identifier : AIDSLINE MED/96142454; Blanche P; Sicard D
[Visceral leishmaniasis and human immunodeficiency virus (HIV) infection in the south of France (letter)]: Presse Med. 1995 Nov 18;24(35):1666. Unique Identifier : AIDSLINE MED/96142422; Rosenthal E; Marty P; Cassuto JP
[Blastocystis hominis: a common commensal in the colon. Study of prevalence in different populations of Paris]: Presse Med. 1995 Nov 25;24(36):1684-8. Unique Identifier : AIDSLINE MED/96140501; Junod C; Laboratoire de Parasitologie-Coprologie, Paris.; OBJECTIVES: To compare the prevalence of Blastocystis hominis in different population categories in Paris, including immunodepressed subjects. METHODS: Stool examinations were performed for 7,677 patients to determine the prevalence of Blastocystis hominis. RESULTS: Prevalence varied according to the population group:
[Toxic dermatitis caused by pyrimethamine in patients with acquired immunodeficiency virus infection (letter)]: Presse Med. 1995 Nov 25;24(36):1710. Unique Identifier : AIDSLINE MED/96140513; Piketty C; Weiss L; Picard-Dahan C; Fegueux S; Belaich S; Kazatchkine MD
Simultaneous syphilitic necrotizing retinitis and placoid chorioretinitis in acquired immune deficiency syndrome.: Retina. 1995;15(4):354-6. Unique Identifier : AIDSLINE MED/96034608; Dodds EM; Lowder CY; Boskovich SA; Longworth DL; Foster RE; Division of Ophthalmology, Cleveland Clinic Foundation, Ohio,; USA.
CT/MRI of musculoskeletal complications of AIDS.: Skeletal Radiol. 1995 Oct;24(7):481-8. Unique Identifier : AIDSLINE MED/96131792; Wyatt SH; Fishman EK; Russell H. Morgan Department of Radiology and Radiological; Science, Baltimore, Maryland, USA.; While uncommon, many musculoskeletal disorders may be seen in association with the acquired immune deficiency syndrome (AIDS). Infections such as osteomyelitis, bacterial myositis and septic arthritis, neoplasms such as non-Hodgkin lymphoma and Kaposi sarcoma, and myopathies and polymyositis have been reported in this
Sexual communication in the age of AIDS: the construction of risk and trust among young adults.: Soc Sci Med. 1995 Nov;41(9):1311-23. Unique Identifier : AIDSLINE MED/96118052; Lear D; Centre for Public Health Research, Queensland University of; Technology, Faculty of Health, Australia.; Sexually transmitted diseases are extremely prevalent among youth, and it is only by understanding the processes involved in negotiating sexual relationships that effective prevention and intervention programs can be designed. This study explores sexual communication among young adults, how gender and sexual orientati
Evaluation of the World Health Organisation antibody-testing strategy for the individual patient diagnosis of HIV infection (strategy III).: S Afr Med J. 1995 Sep;85(9):877-80. Unique Identifier : AIDSLINE MED/96061903; Martin DJ; Blackburn NK; O'Connell KF; Brant ET; Goetsch EA; MRC AIDS Virus Research Unit, National Institute for Virology,; Johannesburg.; OBJECTIVE. To evaluate the World Health Organisation (WHO) antibody testing strategy for the individual patient diagnosis of HIV infection (strategy III). DESIGN. Evaluation of a combination of enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to HIV-1 and HIV-2 infection. The WHO strategy II
HIV in pregnancy--a policy needed [letter]: S Afr Med J. 1995 Sep;85(9):936. Unique Identifier : AIDSLINE MED/96061924; Anthony J; Coetzee EJ; Kent AP; van der Spuy ZM; Denny LA; Stewart CJ; de Jong PR; van Coeverden de Groot HA
Sarcomas in organ allograft recipients.: Transplantation. 1995 Dec 27;60(12):1485-91. Unique Identifier : AIDSLINE MED/96125836; Penn I; Department of Surgery, University of Cincinnati Medical Center,; Ohio, USA.; In a review of 8724 de novo malignancies that occurred in 8191 organ allograft recipients sarcomas were 7.4% of cancers. Kaposi s sarcoma (KS) made up 5.7%, and other sarcomas (OS) 1.7% a much higher proportion than in the general population. KS was most common in Arab, black, Italian, Jewish, or Greek patients. In 60
Direct evidence for in vivo induction of CD8+ cytotoxic T cells directed to donor MHC class I peptides following mouse allotransplantation.: Transplantation. 1995 Dec 27;60(12):1621-4. Unique Identifier : AIDSLINE MED/96125859; Popov IA; Fedoseyeva EV; Orr PL; Garovoy MR; Benichou G; Department of Surgery, University of California San Francisco; 94143-0508, USA.; There is accumulating evidence indicating that the T cell response to donor major histocompatibility complex (MHC) peptides plays a crucial role in graft rejection. We and others previously demonstrated the involvement of MHC class-II-restricted recognition of donor MHC class I and II peptides by alloreactive CD4+ T h
The pathologist in virology.: Vet Microbiol. 1995 Sep;46(1-3):233-42. Unique Identifier : AIDSLINE MED/96107038; Campbell RS; Department of Biomedical and Tropical Veterinary Sciences, James; Cook University, Townsville, Qld., Australia.; While the study of a virus may be the domain of a virologist or molecular biologist, an understanding of the pattern and dynamics of a viral disease in the animal requires a multidisciplinary attack by a team that includes a pathologist. This balance is particularly needed in the field where natural disease can be sub
Virology before and after HIV.: Vet Microbiol. 1995 Sep;46(1-3):243-7. Unique Identifier : AIDSLINE MED/96107039; Cossart Y; Department of Infectious Diseases, University of Sydney, NSW,; Australia.; The career of Eric French epitomised the pre-HIV era of virology, combining active research, effective administration and scholarship. The pressures of AIDS funding and the concept of strictly controlled, and narrowly focussed, mission-oriented research threaten the viability of independent research and may retard pro
Feline immunodeficiency virus replicates in salivary gland ductular epithelium during the initial phase of infection.: Vet Microbiol. 1995 Sep;46(1-3):257-67. Unique Identifier : AIDSLINE MED/96107041; Park HS; Kyaw-Tanner M; Thomas J; Robinson WF; Department of Veterinary Pathology, University of Queensland,; Brisbane, Australia.; Feline immunodeficiency virus (FIV) antigen was detected by immunochemistry in salivary glands of cats experimentally inoculated with West Australian isolate T91. Six cats were inoculated subcutaneously with 1.0 ml of tissue culture supernatant fluid from a feline T-lymphoblastoid cell line (MYA-1) infected with T91.
Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy.: Acta Neuropathol (Berl). 1995;90(4):366-74. Unique Identifier : AIDSLINE MED/96105464; Morgello S; Wolfe D; Godfrey E; Feinstein R; Tagliati M; Simpson DM; Department of Pathology (Division of Neuropathology, Mount Sinai; Medical Center, New York City, NY 10029, USA.; There is controversy as to whether zidovudine (ZDV) induces a mitochondrial myopathy that is distinguishable from human immunodeficiency virus (HIV)-associated myopathy in ZDV-naive patients. Mitochondrial abnormalities were evaluated in skeletal muscle obtained from 18 HIV-positive, ZDV-exposed patients, and 9 who we
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene.: Am J Pathol. 1996 Jan;148(1):17-23. Unique Identifier : AIDSLINE MED/96133074; Chen WG; Chen YY; Bacchi MM; Bacchi CE; Alvarenga M; Weiss LM; Department of Pathology, City of Hope National Medical Center,; Duarte, California 91010, USA.; Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt s lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to be EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3 end of the latent me
Neuronal pattern correlates with the severity of human immunodeficiency virus-associated dementia complex. Usefulness of spatial pattern analysis in clinicopathological studies.: Am J Pathol. 1996 Jan;148(1):31-8. Unique Identifier : AIDSLINE MED/96133076; Asare E; Dunn G; Glass J; McArthur J; Luthert P; Lantos P; Everall I; Department of Neuropathology, Institute of Psychiatry, De; Crespigny Park, London, United Kingdom.; The spatial distributional pattern of neurons, in the superior frontal gyrus of 32 subjects who died of acquired immune deficiency syndrome, was examined. The patients were classified as nondemented, mildly demented, and severely demented, and some were treated with the anti-retroviral drug zidovudine. Spatial statist
Allogeneic transfusion risks in the surgical patient.: Am J Surg. 1995 Dec;170(6A Suppl):21S-26S. Unique Identifier : AIDSLINE MED/96140153; Klein HG; Department of Transfusion Medicine, Warren Grant Magnuson; Clinical Center, National Institutes of Health, Bethesda,; Maryland 20892, USA.; The risk of blood transfusion-associated complications has been reduced in the past 10 years through technical advances in testing of blood, viral inactivation of noncellular blood components, enforcement of stringent donor selection criteria, and the use of alternatives to allogeneic transfusion. Even so, a zero-risk
Ocular complication in HIV infected individuals.: Alaska Med. 1995 Jul-Sep;37(3):91-100. Unique Identifier : AIDSLINE MED/96045823; Harrison TJ; The incidence of acquired immunodeficiency syndrome is growing within all levels of Alaskan society. All physicians will be touched in some manner by this epidemic and there is a growing need for a thorough understanding of all aspects of the human immunodeficiency virus and acquired immunodeficiency syndrome. Visual
Characteristics and performance of the external quality assessment scheme (EQAS) for haematology in Spain. Ten years of experience.: Ann Ist Super Sanita. 1995;31(1):95-101. Unique Identifier : AIDSLINE MED/96107838; Vives-Corrons JL; Gutierrez G; Jou JM; Reverter JC; Martinez-Brotons F; Domingo A; Iriarte JA; Hospital Clinic i Provincial, University of Barcelona, Spain.; The external quality assessment scheme for haematology (EQAS-H) in Spain started in 1984 with 56 laboratories, being 473 in 1994. Participants come from public health services (70%) and from private laboratories (30%). Surveys are performed monthly or quarterly depending on the test
Retroviral vectors for HIV immunotherapy.: Ann N Y Acad Sci. 1995 Nov 27;772:105-16. Unique Identifier : AIDSLINE MED/96135351; Warner JF; Jolly D; Mento S; Galpin J; Haubrich R; Merritt J; Viagene, Inc., San Diego, California 92121, USA.
Obtaining marketing authorization for nucleic acid vaccines in the European Union.: Ann N Y Acad Sci. 1995 Nov 27;772:178-85. Unique Identifier : AIDSLINE MED/96135358; Cichutek K; Department of Medical Biotechnology, Paul-Ehrlich-Institute,; Langen, Germany.; Nucleic acid vaccines are promising candidates for easy-to-handle and cost-effective vaccines that combine the safety of subunit vaccines with the efficacy of live virus vaccines. In order to obtain marketing authorization for a nucleic acid vaccine in all member states of the European Union, a single application doss
DNA inoculation induces cross clade anti-HIV-1 responses.: Ann N Y Acad Sci. 1995 Nov 27;772:186-97. Unique Identifier : AIDSLINE MED/96135359; Wang B; Boyer J; Srikantan V; Ugen K; Agadjanian M; Merva M; Gilbert L; Dang K; McCallus D; Moelling K; et al; Apollon Inc., Malvern, Pennsylvania, USA.; Nucleic acid or DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injection of expression cassettes into a living host results in in vivo gene expression and immune activation. In the case of HIV-1 it has been shown by our laboratory that facilitated injection mimic
Cytotoxic T lymphocyte and helper T cell responses following HIV polynucleotide vaccination.: Ann N Y Acad Sci. 1995 Nov 27;772:198-208. Unique Identifier : AIDSLINE MED/96135360; Shiver JW; Perry HC; Davies ME; Freed DC; Liu MA; Department of Virus and Cell Biology, Merck Research; Laboratories, West Point, Pennsylvania 19486, USA.; Expression vectors encoding either HIV-1 gp160/rev, gp120, or rev alone were used for direct vaccination of mice and nonhuman primates. Each vaccine elicited long-lived (> 7 months) helper T cell responses in mice and monkeys as measured by in vitro proliferation of splenocytes following recombinant antigen treatment.
Simian immunodeficiency virus DNA vaccine trial in macaques.: Ann N Y Acad Sci. 1995 Nov 27;772:209-11. Unique Identifier : AIDSLINE MED/96135361; Robinson HL; Lu S; Mustafa F; Johnson E; Santoro JC; Arthos J; Winsink J; Mullins JI; Montefiori D; Yasutomi Y; et al; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655, USA.
The immune response to HIV gp120 induced by nucleic acid immunization (NAI).: Ann N Y Acad Sci. 1995 Nov 27;772:257-60. Unique Identifier : AIDSLINE MED/96135368; Peet N; Delves PJ; de Souza B; Cambridge G; Wilkinson L; Klonisch T; Matear P; Vyakarnam A; Lund T; Department of Immunology, University College London Medical; School, United Kingdom.
Nucleic acid vaccination with HIV regulatory genes.: Ann N Y Acad Sci. 1995 Nov 27;772:278-81. Unique Identifier : AIDSLINE MED/96135374; Wahren B; Hinkula J; Stahle EL; Borrebaeck CA; Schwartz S; Wigzell H; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
Immune responses to hepatitis B virus surface and core antigens in mice, monkeys, and pigs after Accell particle-mediated DNA immunization.: Ann N Y Acad Sci. 1995 Nov 27;772:282-4. Unique Identifier : AIDSLINE MED/96135375; Fuller JT; Fuller DH; McCabe D; Haynes JR; Widera G; Agracetus, Inc., Middleton, Wisconsin 53562, USA.
Persistent perineal ulcerations. Erosive herpes simplex.: Arch Dermatol. 1996 Jan;132(1):81, 84. Unique Identifier : AIDSLINE MED/96133129; Dietrich SM; Goldfarb JN; Southern Illinois University School of Medicine, Springfield,; USA.
Maternal HIV infection, drug use, and growth of uninfected children in their first 3 years.: Arch Dis Child. 1995 Dec;73(6):490-5. Unique Identifier : AIDSLINE MED/96148383; Ross A; Raab GM; Mok J; Gilkison S; Hamilton B; Johnstone FD; MRC Biostatistics Initiative for AIDS and HIV in Scotland, Centre; for HIV Research, Edinburgh.; OBJECTIVE--To determine the separate effects of maternal HIV infection and drug use during pregnancy on growth of uninfected children in their first 3 years. DESIGN--Retrospective analysis of measurements from health visitor records made during routine child health surveillance at 6 weeks, 10 months, and 3 years of ag
Effect of comprehensive intervention program on survival of patients with human immunodeficiency virus infection.: Arch Intern Med. 1996 Jan 22;156(2):169-76. Unique Identifier : AIDSLINE MED/96135998; Laraque F; Greene A; Triano-Davis JW; Altman R; Lin-Greenberg A; Epidemic Intelligence Service, Centers for Disease Control and; Prevention, Atlanta, Ga, USA.; BACKGROUND: In October 1989, an early intervention program (EIP) for human immunodeficiency virus (HIV) infection was initiated in New Jersey to provide medical care and social services to the enrollees. OBJECTIVE: To assess the overall effect of the EIP on the survival of HIV-infected patients. METHODS: Patient infor
A meta-analysis of the relative efficacy and toxicity of Pneumocystis carinii prophylactic regimens.: Arch Intern Med. 1996 Jan 22;156(2):177-88. Unique Identifier : AIDSLINE MED/96135999; Ioannidis JP; Cappelleri JC; Skolnik PR; Lau J; Sacks HS; Division of Geographic Medicine and Infectious Diseases, New; England Medical Center Hospitals, Boston, Mass, USA.; BACKGROUND: Finding the optimal strategy for Pneumocystis carinii prophylaxis in patients with human immunodeficiency virus infection can be problematic. Several prophylactic regimens are available, but their relative efficacy and tolerance are not well understood. METHODS: A meta-analysis overviewed 35 randomized tri
Lack of usefulness of radiographic screening for pulmonary disease in asymptomatic HIV-infected adults. Pulmonary Complications of HIV Infection Study Group.: Arch Intern Med. 1996 Jan 22;156(2):191-5. Unique Identifier : AIDSLINE MED/96136000; Schneider RF; Hansen NI; Rosen MJ; Kvale PA; Fulkerson WJ Jr; Goodman P; Meiselman L; Glassroth J; Reichman LB; Wallace JM; Hopewell PC; Beth Israel Medical Center, New York, NY, USA.; OBJECTIVE: To determine the use of chest radiographs in the screening of asymptomatic adults infected with the human immunodeficiency virus (HIV). METHODS: A prospective, multicenter study of the pulmonary complications of HIV infection in a community-based cohort of persons with and without HIV infection. The subject
Determinants of nontraditional therapy use in patients with HIV infection. A prospective study.: Arch Intern Med. 1996 Jan 22;156(2):197-201. Unique Identifier : AIDSLINE MED/96136001; Singh N; Squier C; Sivek C; Nguyen MH; Wagener M; Yu VL; Infectious Diseases Section, Veterans Affairs Medical Center,; Pittsburgh, PA, USA.; BACKGROUND: The popularity and use of nontraditional therapies among patients with human immunodeficiency virus (HIV) infection has grown enormously. DESIGN: A prospective, longitudinal cohort study of 56 patients aged 23 through 68 years with HIV infection followed up at the HIV clinic at a university-affiliated Vete
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.: Arch Intern Med. 1996 Jan 22;156(2):202-4. Unique Identifier : AIDSLINE MED/96136002; Chang Y; Ziegler J; Wabinga H; Katangole-Mbidde E; Boshoff C; Schulz T; Whitby D; Maddalena D; Jaffe HW; Weiss RA; Moore PS; Department of Pathology, Columbia University, New York, NY, USA.; BACKGROUND: Endemic Kaposi s sarcoma (KS) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of KS occurring in Africa. Kaposi s sarcoma is now the most frequently reported cancer in some areas of Africa. OBJECTIVE: To determine if a KS-associated herpesvirus (KSHV) is present in
The antiinflammatory and antiviral effects of hydroxychloroquine in two patients with acquired immunodeficiency syndrome and active inflammatory arthritis.: Arthritis Rheum. 1996 Jan;39(1):157-61. Unique Identifier : AIDSLINE MED/96133275; Ornstein MH; Sperber K; Division of the Rheumatology, Mount Sinai Medical Center, New; York, NY 10029, USA.; OBJECTIVE. To report the antiinflammatory and antiviral effects of hydroxychloroquine (HCQ) treatment in 2 patients with AIDS and inflammatory arthritis. METHODS. Two patients with AIDS and inflammatory arthritis were treated with HCQ, which was given in a loading dose of 600 mg/day. The maintenance dosage was calcula
Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens.: Arthritis Rheum. 1996 Jan;39(1):52-6. Unique Identifier : AIDSLINE MED/96133261; Choy EH; Pitzalis C; Cauli A; Bijl JA; Schantz A; Woody J; Kingsley GH; Panayi GS; Guy's Hospital, UMDS, London, England.; OBJECTIVE. We assessed the effect of a daily dosing schedule of the chimeric anti-CD4 monoclonal antibody (MAb), cM-T412, in rheumatoid arthritis (RA) patients, and compared lymphocyte changes in the peripheral blood (PB) and synovial fluid (SF) of these patients. METHODS. Twelve patients received 50 mg/day of cM-T412
Loss of Gag-specific antibody reactivity in cattle experimentally infected with bovine immunodeficiency-like virus.: Viral Immunol. 1995;8(1):27-36. Unique Identifier : AIDSLINE MED/96124511; Isaacson JA; Roth JA; Wood C; Carpenter S; Department of Microbiology, Immunology and Preventive Medicine,; College of Veterinary Medicine, Iowa State University, Ames; 50011, USA.; The development and persistence of virus-specific antibodies were investigated in eight cattle experimentally infected with the R29 isolate of bovine immunodeficiency-like virus (BIV). By 4 weeks postinoculation (p.i.), antibodies reactive to BIV gag- and env-encoded recombinant fusion proteins were detectable by immu
HIV infection/AIDS and critical care.: Crit Care Nurs Clin North Am. 1995 Dec;7(4):651-9. Unique Identifier : AIDSLINE MED/96153169; Leibowitz RE; Tatarakis J; Delgado J; The complications of HIV infection may involve almost any organ system, often resulting in severe dysfunction that may be life threatening. Other disorders not associated with HIV infection may occur in HIV-infected patients and may be severe enough to require critical care. The risk for HIV infection may be unrecogni
Are children who clear HIV truly uninfected? [news]: Nurs Stand. 1995 Oct 25-31;10(5):14. Unique Identifier : AIDSLINE MED/96138810; Giaquinto C; De Rossi A
An old scourge returns.: Nurs Stand. 1995 Oct 25-31;10(5):23-5. Unique Identifier : AIDSLINE MED/96138814; Firn S
Mucocutaneous histoplasmosis in AIDS.: Br J Dermatol. 1995 Sep;133(3):472-4. Unique Identifier : AIDSLINE MED/96142580; Souza Filho FJ; Lopes M; Almeida OP; Scully C; Department of Oral Pathology, University of Campinas,; Picacicaba-SP, Brazil.; A 36-year-old man, who was an intravenous drug abuser, developed thoracic herpes zoster, paronychia, oral candidosis, necrotizing gingivitis and bilateral parotid salivary gland swelling. Granulomatous oral lesions and ulceration on the nose were shown to be due to disseminated histoplasmosis.
Diversity of immunobiological functions of T-cell lines established from patients with adult T-cell leukaemia.: Br J Dermatol. 1995 Dec;133(6):861-7. Unique Identifier : AIDSLINE MED/96150394; Iwatsuki K; Harada H; Motoki Y; Kaneko F; Jin F; Takigawa M; Department of Dermatology, Fukushima Medical College, Japan.; In order to understand the variety of HTLV-1-associated cutaneous diseases, we studied the cytological profile of HTLV-1-infected T-cell lines established from patients with adult T-cell leukaemia (ATL). Among four CD4+ cell lines, termed 16T(-), 35T(-), MH-1, and KS-2, the 16T(-) cells secreted elevated quantities of
Satisfactory remission achieved by PUVA therapy in a case of crisis-type adult T-cell leukaemia/lymphoma with generalized cutaneous leukaemic cell infiltration.: Br J Dermatol. 1995 Dec;133(6):955-60. Unique Identifier : AIDSLINE MED/96150409; Takemori N; Hirai K; Onodera R; Saito N; Yokota K; Kinouchi M; Takahashi H; Iizuka H; Third Department of Internal Medicine, Asahikawa Medical College,; Japan.; We used PUVA therapy in a patient with crisis-type adult T-cell leukaemia/lymphoma and generalized cutaneous leukaemic cell infiltration. PUVA proved very effective in reducing leukaemic cells and in clearing the eruption. To understand the way in which PUVA produced a reduction in the number of leukaemic cells, we ex
Bacillary angiomatosis in HIV-infected patients: report of three cases with different clinical courses and identification of Rochalimaea quintana as the aetiological agent.: Br J Dermatol. 1995 Dec;133(6):983-9. Unique Identifier : AIDSLINE MED/96150414; Bachelez H; Oksenhendler E; Lebbe C; Dauga C; Pinquier L; Mainguene C; Clauvel JP; Grimont PA; Morel P; Dubertret L; et al; Clinique des Maladies Cutanees, Hopital Saint-Louis, Paris,; France.; Three cases of cutaneous bacillary angiomatosis in HIV-infected patients are reported. They differed profoundly with respect to the extent of the lesions and the clinical course. In two cases, Rochalimaea quintana was identified by direct sequencing of the DNA amplified with
Pityriasis rubra pilaris and human immunodeficiency virus infection.: Br J Dermatol. 1995 Dec;133(6):990-3. Unique Identifier : AIDSLINE MED/96150415; Miralles ES; Nunez M; De Las Heras ME; Perez B; Moreno R; Ledo A; Servicio de Dermatologia Unisversidad Alcala de Henares,; Hospital Ramon y Cajal, Madrid, Spain.; Recently, the occurrence of pityriasis rubra pilaris (PRP) has been reported in patients with HIV infection. It presents different clinical features, and has a poorer prognosis, than the classical adult type of PRP. We report the occurrence of severe PRP in an HIV-infected patient, and review the previously reported c
The CD4 receptor plays essential but distinct roles in HIV-1 infection and induction of apoptosis in primary bone marrow GPIIb/IIIa+ megakaryocytes and the HEL cell line.: Br J Haematol. 1995 Oct;91(2):290-8. Unique Identifier : AIDSLINE MED/96027647; Zauli G; Catani L; Gibellini D; Re MC; Milani D; Borgatti P; Bassini A; La Placa M; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; We investigated whether cells belonging to the megakaryocytic lineage could be infected in vitro with human immunodeficiency virus type-1 (HIV-1). Primary GPIIb/IIIa+ bone marrow (BM) cells and HEL continuous cell line were first phenotypically characterized for the presence of megakaryocytic markers and CD4 antigen,
Virus infection-associated improvement of platelet counts in chronic ITP [letter]: Br J Haematol. 1995 Oct;91(2):517-8. Unique Identifier : AIDSLINE MED/96027691; Costello C
Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain.: Br J Haematol. 1995 Dec;91(4):918-20. Unique Identifier : AIDSLINE MED/96136090; Pastore C; Gloghini A; Volpe G; Nomdedeu J; Leonardo E; Mazza U; Saglio G; Carbone A; Gaidano G; Laboratorio di Medicina e Oncologia Molecolare, Dipartimento di; Scienze Biomediche e Oncologia Umana, Italy.; In this study we have tested the distribution of Kaposi s sarcoma herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid neoplasia in Italy and Spain . 180 cases of lymphoid malignancies representative of the major histologic and immu
Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues.: Br J Haematol. 1995 Dec;91(4):927-31. Unique Identifier : AIDSLINE MED/96136093; Durkop H; Latza U; Himmelreich P; Stein H; Institute of Pathology, Klinikum Benjamin Franklin, Free; University of Berlin, Germany.; The Ber-ACT35 mAb was raised against the human T-cell lymphotrophic virus (HTLV) 1-transformed, CD4+ HUT 102 cell line and recognizes the human homologue of the OX40 (hOX40) antigen. The analysis of the expression of hOX40 by immunohistochemical techniques in malignant lymphomas, carcinomas and non-malignant tissues o
EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair deletion in the LMP-1 oncogene.: Br J Haematol. 1995 Dec;91(4):938-40. Unique Identifier : AIDSLINE MED/96136096; Klein C; Rothenberger S; Niemeyer C; Bachmann E; Odermatt B; Bohm N; Brandis M; Knecht H; University Children's Hospital, Freiburg, Germany.; We describe an immunocompetent 12-year-old boy with chronic EBV infection and lymphoid interstitial pneumonitis. Lymph node biopsies showed effacement of the architecture with polymorphic cellular infiltrates, consisting predominantly of T cells and natural killer cells. No clonal rearrangement of TCR or immunoglobuli
HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors.: Biochemistry. 1996 Jan 23;35(3):1054-63. Unique Identifier : AIDSLINE MED/96146442; Spence RA; Anderson KS; Johnson KA; Department of Biochemistry and Molecular Biology, Pennsylvania; State University, University Park 16802, USA.; The parameters governing the polymerization mechanism of reverse transcriptase containing the tyrosine to cysteine mutation at position 181 (Y181C) were determined using pre-steady-state techniques. The pathway for single nucleotide incorporation catalyzed by Y181C is similar to that determined for wild-type RT where
Structural study of the interaction between the SIV fusion peptide and model membranes.: Biochemistry. 1996 Jan 23;35(3):980-9. Unique Identifier : AIDSLINE MED/96146434; Colotto A; Martin I; Ruysschaert JM; Sen A; Hui SW; Epand RM; Department of Biochemistry, McMaster University, Hamilton,; Ontario, Canada.; It has been shown that there is a correlation between the fusogenecity of synthetic peptides corresponding to the N-terminal segment of wild-type and mutant forms of simian immunodeficiency virus gp32 (SIV) and their mode of insertion into lipid bilayers. Fusogenic activity is only observed when the peptide inserts in
Resource allocation, health policy, and rationing craniofacial care.: Cleft Palate Craniofac J. 1995 Nov;32(6):515-9. Unique Identifier : AIDSLINE MED/96156391; Strauss RP; Department of Dental Ecology, School of Dentistry, University of; North Carolina at Chapel Hill 27599-7450, USA.; The United States allocates health care without an overt system of rationing. This article analyzes the forces that guide resource allocation to craniofacial care. Various possible allocation systems are reviewed for how decision makers might evaluate proposed programs for legislative
Signalling and transport through the nuclear membrane.: Biochim Biophys Acta. 1995 Dec 20;1241(3):425-51. Unique Identifier : AIDSLINE MED/96139318; Csermely P; Schnaider T; Szanto I; Institute of Biochemistry I., Semmelweis University, Budapest,; Hungary.
HIV antibody testing of gay men in smaller US cities.: AIDS Care. 1995;7(4):405-13. Unique Identifier : AIDSLINE MED/96119348; Roffman RA; Kalichman SC; Kelly JA; Winett RA; Solomon LJ; Sikkema KJ; Norman AD; Desiderato LL; Perry MJ; Lemke AL; et al; University of Washington, Seattle, WA 98195, USA.; The incidence of new AIDS diagnoses among gay males indicates that risk reduction in smaller communities may be lagging behind that reported in larger cities. Contradictory evidence exists, largely from urban areas, concerning the utility of HIV testing as a means of promoting behavioural change. This study examined t
Factors associated with Hispanic women's HIV-related communication and condom use with male partners.: AIDS Care. 1995;7(4):415-27. Unique Identifier : AIDSLINE MED/96119349; Moore J; Harrison JS; Kay KL; Deren S; Doll LS; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA.; To determine factors influencing Hispanic women s HIV-related communication and condom use with their primary male partner, 189 Dominican, Puerto Rican, and Mexican women were interviewed regarding sexual behaviour and condom use, relationship characteristics, perceived risk for HIV, and HIV-related communication with
Intimacy and sexual risk behaviour in serodiscordant male couples.: AIDS Care. 1995;7(4):429-38. Unique Identifier : AIDSLINE MED/96119350; Remien RH; Carballo-Dieguez A; Wagner G; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY 10032, USA.; Several studies have demonstrated individual-level determinants of HIV sexual risk behaviour. Very little research has been conducted to identify couple-level factors associated with unsafe sexual behaviour. As part of a three-year study of more than 100 serodiscordant male couples, we conducted an in-depth qualitativ
Zidovudine adherence among individuals with HIV infection.: AIDS Care. 1995;7(4):439-47. Unique Identifier : AIDSLINE MED/96119351; Muma RD; Ross MW; Parcel GS; Pollard RB; Department of Physician Assistant, College of Health Professions,; Wichita State University, Kansas 67260-0043, USA.; The objective was to investigate the relationships among health beliefs, attitudes, and zidovudine compliance in individuals with HIV infection. A survey was administered to 52 individuals with HIV infection. The survey items, which reflected concerns expressed about zidovudine, were generated based on barriers to and
Cross-cultural comparison of US and Nigerian adolescents' HIV-related knowledge, attitudes, and risk behaviour: implications for risk reduction interventions.: AIDS Care. 1995;7(4):449-61. Unique Identifier : AIDSLINE MED/96119352; St. Lawrence JS; Marx BP; Scott CP; Uwakwe CB; Roberts A; Brasfield TL; Community Health Program, Jackson State University, MS 39217,; USA.; Attitudes towards AIDS prevention, AIDS-related knowledge, and sexual behaviour of Nigerian adolescents and their African-American counterparts in two geographic regions of the United States were compared to assess cross-cultural similarities and differences between the adolescents. Th
Group intervention to improve coping with AIDS-related bereavement: model development and an illustrative clinical example.: AIDS Care. 1995;7(4):463-75. Unique Identifier : AIDSLINE MED/96119353; Sikkema KJ; Kalichman SC; Kelly JA; Koob JJ; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226, USA.; Despite the widespread losses from AIDS, there have been no published evaluations of mental health interventions for people experiencing AIDS-related bereavement. We describe a cognitive behavioural coping model for support group interventions with people who experience an AIDS-related loss. The support group model co
HIV/AIDS prevention among female sexual partners of injection drug users in Ciudad Juarez, Mexico.: AIDS Care. 1995;7(4):477-88. Unique Identifier : AIDSLINE MED/96119354; Ferreira-Pinto JB; Ramos R; School of Public Health, University of Texas-Houston, USA.; A participatory community project in the US- Mexico border town of Ciudad Juarez, aimed at helping women who are sex partners of male injection drug users to reduce behaviours which increase their risk for HIV infection, is described and evaluated. The design and implementation of t
Operating needle exchange programmes in the hills of Thailand.: AIDS Care. 1995;7(4):489-99. Unique Identifier : AIDSLINE MED/96119355; Gray J; National Centre for HIV Social Research, School of Behavioural; Sciences, Macquarie University, Sydney, New South Wales,; Australia.; Injecting drug use is increasingly markedly amongst the ethnically distinct Hilltribe peoples of northern Thailand in the notorious Golden Triangle . This paper reports on the establishing of needle exchanges in three remote Hilltribe villages, examining the success and the fail
Promoting safer sexual practices among young adults: a survey of health workers in Moshi Rural District, Tanzania.: AIDS Care. 1995;7(4):501-7. Unique Identifier : AIDSLINE MED/96119356; Ngomuo ET; Klepp KI; Rise J; Mnyika KS; Centre for International Health/Research Centre for Health; Promotion, University of Bergen, Norway.; As part of the national effort to prevent further spread of HIV/AIDS, rural health workers in Tanzania are asked to promote safer sex practices among the sexually active population. We conducted a survey among health workers in Moshi Rural District, Kilimanjaro, designed to asses
Support service use by persons with AIDS and their caregivers.: AIDS Care. 1995;7(4):509-20. Unique Identifier : AIDSLINE MED/96119357; Wight RG; LeBlanc AJ; Aneshensel CS; UCLA School of Public Health, USA.; The purpose of this study was to identify factors related to the use and non-use of emotional and practical support services by persons with AIDS (PWAs) and their informal caregivers. Unmet need for PWA support services and perceived barriers to the use of these types of services were also identified. Structured inter
The implications of HIV/AIDS for a range of workers in the Scottish context.: AIDS Care. 1995;7(4):521-35. Unique Identifier : AIDSLINE MED/96119358; Barbour RS; Public Health Research Unit, Glasgow, UK.; Although there have been a great many surveys of staff members attitudes to HIV/AIDS, there has been relatively little research which has focused on their actual responses to and experiences of AIDS-related work (Barbour, 1994a). In addition, much of the published work on AIDS workers assumes that the demands of this
World Health Organization Global AIDS Statistics.: AIDS Care. 1995;7(4):543-7. Unique Identifier : AIDSLINE MED/96119359
Preventing pelvic infection after abortion [editorial]: Int J STD AIDS. 1995 Sep-Oct;6(5):305-12. Unique Identifier : AIDSLINE MED/96122185; Stevenson MM; Radcliffe KW; Pelvic infection is the commonest complication of legal abortion. The presence of lower genital tract infections increases the risk of complications, and women requesting abortion are at significant risk of harbouring sexually transmitted diseases (STD). Prophylactic antibiotic treatment can decrease the rate of post-
Management of cytomegalovirus infection. The Jefferiss Wing Therapeutics and Protocols Group.: Int J STD AIDS. 1995 Sep-Oct;6(5):313-9. Unique Identifier : AIDSLINE MED/96122186; Fisher M; Tomlinson DR; Coker RJ; Department of Genitourinary Medicine, St Mary's Hospital,; Paddington, London, UK.
Antiviral chemotherapy in genital herpes simplex virus infections.: Int J STD AIDS. 1995 Sep-Oct;6(5):320-8. Unique Identifier : AIDSLINE MED/96122187; Patel R; Barton SE; Southampton University Hospitals, UK.
HIV neurology grey case.: Int J STD AIDS. 1995 Sep-Oct;6(5):329-30. Unique Identifier : AIDSLINE MED/96122188; Greene L; Banks M; St Mary's Hospital, London, UK.
When to perform the final HIV antibody test following possible exposure. The British Co-operative Clinical Group.: Int J STD AIDS. 1995 Sep-Oct;6(5):332-5. Unique Identifier : AIDSLINE MED/96122189; Clinic 1A, Addenbrooke's Hospital, Cambridge, UK.; The senior consultant and senior health adviser in all genitourinary medicine clinics in the UK were sent a questionnaire on HIV testing practice in seven clinical scenarios. For each scenario the recommended time interval between possible exposure and final HIV antibody test varied from a minimum of 3 months to a max
Hospital service utilization by HIV/AIDS patients and their management cost in a provincial genitourinary medicine department.: Int J STD AIDS. 1995 Sep-Oct;6(5):336-44. Unique Identifier : AIDSLINE MED/96122190; Nageswaran A; Kinghorn GR; Shen RN; Priestley CJ; Kyi TT; Department of Genito-Urinary Medicine, Royal Hallamshire; Hospital, Sheffield, UK.; The hospital management of 108 HIV/AIDS patients cared for by the genitourinary medicine department, Sheffield, UK between 1984-93 was retrospectively studied to quantify the services utilized by these patients and to detail the management costs (1993 price) of outpatient (OP) services, inpatient (IP) care, investigat
Epidemic spread of plasmid-mediated tetracycline resistant Neisseria gonorrhoeae in Zaire.: Int J STD AIDS. 1995 Sep-Oct;6(5):345-7. Unique Identifier : AIDSLINE MED/96122191; Van Dyck E; Laga M; Manoka AT; Behets F; Piot P; Division of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; A cohort of 650 prostitutes from Kinshasa, Zaire , was followed at monthly intervals for sexually transmitted diseases as part of an HIV intervention project. Neisseria gonorrhoeae isolates, obtained during a period of 30 months, were auxotyped, serotyped and tested for antimicrobi
Gonorrhoea as an indicator of altered sexual behaviour and as a surrogate marker of HIV concern: a 13-year analysis in Newcastle.: Int J STD AIDS. 1995 Sep-Oct;6(5):348-50. Unique Identifier : AIDSLINE MED/96122192; Wardropper AG; Pattman RS; Department of Genitourinary Medicine, Newcastle General Hospital,; Newcastle upon Tyne, UK.; It has been proposed that changes in sexual behaviour arising out of concerns regarding HIV infection can be inferred by changes in the incidence of gonorrhoea. We have reviewed data on gonococcal isolates in Newcastle over the last 13 years and looked at changes in relation to HIV test requests, new cases of HIV infe
Intralesional interferon for the treatment of recalcitrant molluscum contagiosum in HIV antibody positive individuals--a preliminary report.: Int J STD AIDS. 1995 Sep-Oct;6(5):351-2. Unique Identifier : AIDSLINE MED/96122193; Nelson MR; Chard S; Barton SE; Department of HIV/Genitourinary Medicine, Chelsea & Westminster; Hospital, London, UK.; Molluscum contagiosum is common in HIV disease and available therapies have a poor success rate and require frequent clinic visits. Interferon alpha has been used to treat recalcitrant condylomata acuminata and this study was undertaken to assess the use of this treatment in unresponsive molluscum contagiosum. A total
Azole drug resistance as a cause of clinical relapse in AIDS patients with cryptococcal meningitis.: Int J STD AIDS. 1995 Sep-Oct;6(5):353-5. Unique Identifier : AIDSLINE MED/96122194; Birley HD; Johnson EM; McDonald P; Parry C; Carey PB; Warnock DW; Department of Genito-Urinary Medicine, Royal Liverpool University; Hospital, UK.
Syphilitic aortic aneurysm and squamous cell carcinoma of the penis: a case report.: Int J STD AIDS. 1995 Sep-Oct;6(5):356-60. Unique Identifier : AIDSLINE MED/96122195; el-Gadi SM; Estreich S; Davidson EA; Department of Genitourinary Medicine, Cardiff Royal Infirmary,; UK.
Haemoglobin SC disease presenting as a case of priapism to a GUM clinic.: Int J STD AIDS. 1995 Sep-Oct;6(5):361-2. Unique Identifier : AIDSLINE MED/96122196; Rea AJ; Cavenagh JD; Goh BT; Department of Genitourinary Medicine, Royal London Hospital,; Royal Hosptials' NHS Trust, Whitechapel, UK.
An audit of nurse treatment sessions for female patients with genital warts.: Int J STD AIDS. 1995 Sep-Oct;6(5):363. Unique Identifier : AIDSLINE MED/96122197; Frayne J; Tobin JM; Genitourinary Medicine Department, St Mary's Hospital,; Portsmouth, Hants, UK.
An audit of hepatitis B vaccination compliance rates in two genitourinary medicine clinics.: Int J STD AIDS. 1995 Sep-Oct;6(5):364-5. Unique Identifier : AIDSLINE MED/96122198; Stevenson M; el-Dalil A; Richmond R; Wade AA; Department of Genitourinary Medicine, General Hospital,; Birmingham, UK.
National vulvodynia questionnaire [letter]: Int J STD AIDS. 1995 Sep-Oct;6(5):366-7. Unique Identifier : AIDSLINE MED/96122199; Nunns D; Higgins SP; Mandal D
Morbidity and disease prevalence in male and female sexual contacts of patients with genital chlamydial infection [letter]: Int J STD AIDS. 1995 Sep-Oct;6(5):367-8. Unique Identifier : AIDSLINE MED/96122200; Matondo P; Johnson I; Sivapalan S
Retinoic acid derivatives and HPV infection [letter]: Int J STD AIDS. 1995 Sep-Oct;6(5):368. Unique Identifier : AIDSLINE MED/96122201; Birley HD; Luzzi GA; Taylor-Robinson D; Walker MM; Renton AM
Falling prevalence of Chlamydia trachomatis infection--an alternative explanation [letter]: Int J STD AIDS. 1995 Sep-Oct;6(5):368-9. Unique Identifier : AIDSLINE MED/96122202; Ramasubramanian V; Sampson M; Forster GE; Goh BT
Targeting young people for sexual health counselling [letter]: Int J STD AIDS. 1995 Sep-Oct;6(5):369-70. Unique Identifier : AIDSLINE MED/96122203; Williams E; Dyson A; Golin M; Dymek P; Munday P
USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: introduction. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S1-11. Unique Identifier : AIDSLINE MED/96002823; Kaplan JE; Masur H; Holmes KK; McNeil MM; Schonberger LB; Navin TR; Hanson DL; Gross PA; Jaffe HW; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.
Prospects for preventing cryptococcosis in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S103-7. Unique Identifier : AIDSLINE MED/96002836; Pinner RW; Hajjeh RA; Powderly WG; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Cryptococcosis is a major cause of illness and death among persons infected with human immunodeficiency virus (HIV). Its management must include both initial and maintenance treatment. Although most authorities favor an initial period of therapy with amphotericin B for acute cryptococcosis, the triazoles play a role i
Disseminated histoplasmosis in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S108-10. Unique Identifier : AIDSLINE MED/96002837; Hajjeh RA; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; Disseminated histoplasmosis is an AIDS-defining illness that occurs in about 5% of AIDS patients residing in histoplasmosis-endemic areas of the United States (the Mississippi and Ohio river valleys). This disease develops as a result of acute infection and perhaps also as the result o
Opportunistic coccidioidomycosis in patients infected with human immunodeficiency virus: prevention issues and priorities.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S111-3. Unique Identifier : AIDSLINE MED/96002838; McNeil MM; Ampel NM; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; Coccidioidomycosis is an uncommon AIDS-defining illness that is endemic in the southwestern United States . In profoundly immunodeficient patients infected with human immunodeficiency virus (HIV), the disease is usually manifest as severe pulmonary infection and is associated with high
Herpesvirus infections in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S114-20. Unique Identifier : AIDSLINE MED/96002839; Stewart JA; Reef SE; Pellett PE; Corey L; Whitley RJ; Division of Viral and Rickettsial Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Herpesviruses are among the most common causes of infections of humans. Viruses in this family share the unique biological property of being able to establish latency and to recur. Furthermore, chronic excretion of virus is not uncommon. In the immunocompromised host, including persons with human immunodeficiency viru
USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: an overview. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S12-31. Unique Identifier : AIDSLINE MED/96002824; Kaplan JE; Masur H; Holmes KK; Wilfert CM; Sperling R; Baker SA; Trapnell CB; Freedberg KA; Cotton D; Powderly WG; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Altanta, Georgia 30333, USA.
Human papillomavirus infection and associated disease in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S121-4. Unique Identifier : AIDSLINE MED/96002840; Vernon SD; Holmes KK; Reeves WC; Division of Viral and Rickettsial Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Genital infection with human papillomavirus (HPV) is the most common sexually transmitted infection in the United States . Genital or anal infection with oncogenic types of HPV, particularly types 16 and 18, can cause precancerous lesions of the squamous epithelium. Infection with human
Quality standards for preventing opportunistic infections related to human immunodeficiency virus and their implementation.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S125. Unique Identifier : AIDSLINE MED/96002841; Phair JP; Gross PA; Kaplan JE; Masur H; Holmes KK; Wilfert CM; Northwestern University Medical School, Chicago, IL 60611-4402,; USA.
Quality standard for the enumeration of CD4+ lymphocytes in adults and adolescents infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S126-7. Unique Identifier : AIDSLINE MED/96002842; Gross PA; Phair JP; Kaplan JE; Holmes KK; Masur H; Northwestern University Medical School, Chicago, IL 60611-4402,; USA.
Quality standard for the prophylaxis of Pneumocystis carinii pneumonia in adults and adolescents infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S128-9. Unique Identifier : AIDSLINE MED/96002843; Phair JP; Masur H; Gross PA; Holmes KK; Kaplan JE; Northwestern University Medical School, Chicago, IL 60611-4402,; USA.
Quality standard for the identification and treatment of persons coinfected with human immunodeficiency virus and Mycobacterium tuberculosis.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S130-1. Unique Identifier : AIDSLINE MED/96002844; Phair JP; Gross PA; Kaplan JE; Masur H; Holmes KK; Wilfert CM; Martone WJ; Castro KG; Northwestern University Medical School, Chicago, IL 60611-4402,; USA.
Quality standard for the prophylaxis of Pneumocystis carinii pneumonia in infants and children born to women infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S132-3. Unique Identifier : AIDSLINE MED/96002845; Wilfert CM; Masur H; Gross PA; Kaplan JE; Holmes KK; Phair JP; Simonds RJ; Duke University, Durham, NC, USA.
Quality standard for the enumeration of CD4+ lymphocytes in infants and children exposed to or infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S134-5. Unique Identifier : AIDSLINE MED/96002846; Wilfert CM; Gross PA; Kaplan JE; Holmes KK; Masur H; Phair JP; Simonds RJ; Duke University, Durham, NC 27710, USA.
Quality standard for the immunization of infants and children born to women infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S136-7. Unique Identifier : AIDSLINE MED/96002847; Wilfert CM; Kaplan JE; Gross PA; Masur H; Holmes KK; Phair JP; Duke University, Durham, NC, USA.
Indicators for assessment of compliance with quality standards for the prevention of opportunistic infections in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S138-41. Unique Identifier : AIDSLINE MED/96002848; Gross PA; Kaplan JE; Phair JP; Masur H; Wilfert CM; Holmes KK; Department of Internal Medicine, Hackensack Medical Center, NJ; 07601, USA.
USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. USPHS/IDSA Prevention of Opportunistic Infections Working Group.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S32-43. Unique Identifier : AIDSLINE MED/96002825
Preventing Pneumocystis carinii pneumonia in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S44-8. Unique Identifier : AIDSLINE MED/96002826; Simonds RJ; Hughes WT; Feinberg J; Navin TR; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.; Although the incidence of Pneumocystis carinii pneumonia (PCP) among adults infected with human immunodeficiency virus (HIV) has declined, no decline in PCP incidence has been observed among HIV-infected children, and PCP remains the most common serious opportunistic infection among both adults and children in the
Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S49-56. Unique Identifier : AIDSLINE MED/96002827; Richards FO Jr; Kovacs JA; Luft BJ; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, CDC, Atlanta, Georgia 30333, USA.; Toxoplasmic encephalitis (TE) is the second most common AIDS-related opportunistic infection of the CNS. It occurs in 10%-50% of patients with AIDS who are seropositive for antibodies to Toxoplasma gondii and have CD4+ T lymphocyte counts of
Cryptosporidiosis: sources of infection and guidelines for prevention.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S57-61. Unique Identifier : AIDSLINE MED/96002828; Juranek DD; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30341, USA.; Cryptosporidium parvum is an important emerging pathogen in the United States and a cause of severe, life-threatening disease in patients with AIDS. No safe and effective form of specific treatment for cryptosporidiosis has been identified to date. The parasite is transmitted by ingest
Microsporidiosis as an AIDS-related opportunistic infection.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S62-5. Unique Identifier : AIDSLINE MED/96002829; Bryan RT; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Albuquerque, New Mexico, USA.; The clinical manifestations of AIDS-related microsporidiosis range from mild or asymptomatic infections to debilitating illness involving the gastrointestinal, respiratory, or urogenital tracts or the eyes. Intestinobiliary infections with Enterocytozoon bieneusi are t
Tuberculosis as an opportunistic disease in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S66-71. Unique Identifier : AIDSLINE MED/96002830; Castro KG; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Public Health Service, U.S. Department of Health; and Human Services, Atlanta, Georgia 30333, USA.; Tuberculosis, a bacterial disease caused by the Mycobacterium tuberculosis complex, is becoming an increasingly common opportunistic disease in persons infected with the human immunodeficiency virus (HIV). M. tuberculosis is transmitted from person-to-person by airborne droplet nuclei. Persons who are exposed to these
Preventing disseminated Mycobacterium avium complex disease in patients infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S72-6. Unique Identifier : AIDSLINE MED/96002831; Ostroff SM; Spiegel RA; Feinberg J; Benson CA; Horsburgh CR Jr; Office of the Director, Centers for Disease Control and; Prevention (CDC), Public Health Service U.S. Department of Health; and Human Services, Atlanta, Georgia 30333, USA.; Disseminated Mycobacterium avium complex (MAC) infection is an important late-stage complication of infection with the human immunodeficiency virus. Since MAC is widely dispersed in the environment, the source of infection for patients with disseminated MAC generally cannot be determined. Therefore, specific recommend
Preventing bacterial respiratory tract infections among persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S77-83. Unique Identifier : AIDSLINE MED/96002832; Keller DW; Breiman RF; Respiratory Diseases Epidemiology Section, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Bacterial respiratory tract infections occur frequently in persons infected with human immunodeficiency virus (HIV) and may be caused by a wide variety of pathogens. Pneumonia is the most commonly diagnosed respiratory infection in HIV-infected persons and is more common in those persons than in non-HIV-infected ones.
Bacterial enteric infections in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S84-93. Unique Identifier : AIDSLINE MED/96002833; Angulo FJ; Swerdlow DL; Foodborne and Diarrheal Diseases Branch, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; We review the epidemiology and prevention of and future research priorities for bacterial enteric infections in persons infected with the human immunodeficiency virus (HIV). HIV-infected persons are more frequently infected with Salmonella, Campylobacter, Listeria, and (possibly) Shigella species than are individuals
Infections associated with Bartonella species in persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S94-8. Unique Identifier : AIDSLINE MED/96002834; Regnery RL; Childs JE; Koehler JE; Viral and Rickettsial Zoonoses Branch, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Two members of the genus Bartonella, Bartonella quintana (formerly Rochalimaea quintana) and Bartonella henselae (formerly Rochalimaea henselae), have recently been recognized as agents of severe or fatal disease in patients infected with human immunodeficiency virus (HIV). The development of infection with B. hensela
Opportunistic candidal infections in patients infected with human immunodeficiency virus: prevention issues and priorities.: Clin Infect Dis. 1995 Aug;21 Suppl 1:S99-102. Unique Identifier : AIDSLINE MED/96002835; Reef SE; Mayer KH; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; Mucosal candidiasis (oropharyngeal, esophageal, and vulvovaginal candidiasis) has been among the most prominent opportunistic infections in persons infected with human immunodeficiency virus (HIV). Esophageal candidiasis, an AIDS-defining illness, accounted for 15% of the AIDS-defining illnesses in adults and adolesce
Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.: Int J Hematol. 1995 Jun;61(4):215-22. Unique Identifier : AIDSLINE MED/96164754; Hayashi T; Yamabe H; Haga H; Akasaka T; Kadowaki N; Ohno H; Okuma M; Fukuhara S; Department of Internal Medicine, Kyoto University, Japan.; We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin s disease (HD). Large atypical Reed-Sternberg/Hodgkin s cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein
Kaposi sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease: is there any relevant association in non-human immunodeficiency virus-infected patients? [letter]: Blood. 1996 Jan 1;87(1):414-6. Unique Identifier : AIDSLINE MED/96125049; Gessain A; Sudaka A; Briere J; Fouchard N; Nicola MA; Rio B; Arborio M; Troussard X; Audouin J; Diebold J; de The G
Human immunodeficiency virus and acquired immune deficiency syndrome AIDS-related hearing disorders.: J Am Acad Audiol. 1995 Sep;6(5):358-64. Unique Identifier : AIDSLINE MED/96052906; Madriz JJ; Herrera G; Department of Otorhinolaryngology, Ministry of Health, San Jose,; Costa Rica.; After a brief discussion of the nature of the human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) disease process and its consequences, the article considers implications for the ear and hearing. One of the newest etiologic considerations for audiologists is pediatric autoimmune deficiency sy
CD4 enumeration in HIV infected individuals.: Eur J Histochem. 1994;38 Suppl 1:35-40. Unique Identifier : AIDSLINE MED/96120977; Lopez A; Ciudad J; Cordero M; Orfao A; Servicio General de Citometria, University of Salamanca, Spain.; In the present study, two alternative methods for the enumeration of PB CD4+ lymphocytes are compared with conventional flow cytometry (FCM): the TRAX CD4 tm enzyme immunoassay test kit and a new method using an internal biological standard (liophilized lymphocytes) for the direct enumeration of total PB CD4+ T-cells.
Detection of T cell CD4 epitopes in HIV-infected individuals.: Eur J Histochem. 1994;38 Suppl 1:41-6. Unique Identifier : AIDSLINE MED/96120978; Kunkl A; Valle MT; Fenoglio D; Dodi F; Morandi N; Rizzo F; Manca F; Department of Immunology, San Martino Hospital, Genoa, Italy.; HIV antigens can be detected in the circulation of HIV-infected patients and are associated with active virus production. Free virions and shedded gp120 bind CD4 with high affinity. We have studied the expression of Leu3a and OKT4 epitopes on a CD4+ T cell line (HPB-ALL), pretreated with HIV rgp120, and on CD4+ pherip
Quality control in immunophenotyping: U.S. efforts to establish common methodology and their impact. American Society for Histocompatibility and Immunogenetics.: Eur J Histochem. 1994;38 Suppl 1:7-12. Unique Identifier : AIDSLINE MED/96120973; Nicholson JK; Immunology Branch, Centers for Disease Control and Prevention,; Atlanta, GA, USA.; Several organizations in the United States have recently been involved in the quality assurance of immunophenotyping using flow cytometry. These activities include publication of guidelines for immunophenotyping, particularly in human immunodeficiency virus infection, performance evalu
AIDS in older patients: a problem of increasing concern.: R I Med. 1995 Nov;78(11):324-5. Unique Identifier : AIDSLINE MED/96137709; Stein WM; Fagan M; Rhode Island Hospital, USA.
Topical fumagillin in the treatment of microsporidial keratoconjunctivitis in AIDS.: Ann Pharmacother. 1995 Sep;29(9):872-4. Unique Identifier : AIDSLINE MED/96087306; Garvey MJ; Ambrose PG; Ulmer JL; University of California, Davis Medical Center, Sacramento 95817,; USA.; OBJECTIVE: To report microsporidial keratoconjunctivitis in a patient infected with HIV who was treated with topical fumagillin. CASE SUMMARY: A 37-year-old white man who was experiencing redness, pain, irritation, decreased vision, and a foreign body sensation occurring in both eyes was referred to the ophthalmology
Services for children with HIV/AIDS: the views of parents.: Prof Care Mother Child. 1995;5(4):107-12. Unique Identifier : AIDSLINE MED/96140123; Barrett G; Victor CR; In this qualitative study, the parents of ten children who attended an inner-London teaching hospital for HIV/AIDS were interviewed to find out their views on the services. Speaking from their own experiences, parents expressed a high level of satisfaction with the specialist paediatric care at the teaching hospital b
A revised strategy for HIV and AIDS health promotion.: Commun Dis Rep CDR Wkly. 1995 Dec 1;5(48):263. Unique Identifier : AIDSLINE MED/96114377
[Camphor poisoning: repeatedly? (letter)]: Arch Pediatr. 1995 Nov;2(11):1121. Unique Identifier : AIDSLINE MED/96145011; Larchet M; Beauvais P
[The global offensive against AIDS: together for the future (materials of the 10th International AIDS Congress) (news)]: Mikrobiol Z. 1995 Jul-Aug;57(4):108-11. Unique Identifier : AIDSLINE MED/96166311; Shcherbinskaia AM
[Carbohydrate receptors for Mycoplasma fermentans adhesion on human epithelial tissues]: Mikrobiol Z. 1995 Jul-Aug;57(4):17-22. Unique Identifier : AIDSLINE MED/96099077; Skrypal' IH; Tokovenko IP; Malynovs'ka LP; It has been stated that two terminal carbohydrates from polysaccharide complexes which are on the surface of human epithelial tissues, namely, alpha-D-glucose and N-acetylneuramino acid bound with subterminal galactose via alpha 2-->3-bond (NeuAc alpha 2-->3 Gal), may serve receptors for Mycoplasma fermentans adhesion
Molecular biological bases of resistance to HIV/AIDS (the hypothesis with elements of the theory).: Mikrobiol Z. 1995 Jul-Aug;57(4):89-105. Unique Identifier : AIDSLINE MED/96099084; Skripal IG; D. K. Zabolotny Institute of Microbiology and Virology, National; Academy of Sciences of Ukraine, Kiev.; Proceeding from the structure and function of the shell glycoprotein gp120 of the human immunodeficiency virus (HIV) and receptor glycoprotein CD4 on target cells for this virus, the author assumes that in nature there is genetically determined human resistance to the HIV infection and AIDS. This resistance manifests
Extending the elements of tree-structured regression.: Stat Methods Med Res. 1995 Sep;4(3):219-36. Unique Identifier : AIDSLINE MED/96118082; Segal MR; Division of Biostatistics, University of California, San; Francisco 94143-0560, USA.; The usage of tree-structured or recursive partitioning methods has grown steadily in the decade since the appearance of the definitive monograph Classification and Regression Trees . Accompanying this growth have been many methodologic and software extensions that have served to give the tree-structured approach even
Herpes simplex virus resistance to acyclovir: clinical relevance.: Infect Agents Dis. 1995 Sep;4(3):115-24. Unique Identifier : AIDSLINE MED/96034253; Pottage JC Jr; Kessler HA; Department of Medicine, Rush Medical College, Chicago, Illinois,; USA.; Herpes simplex virus (HSV) infections are very common in the general population and can be treated with the nucleoside analogue acyclovir. Acyclovir is initially phosphorylated intracellularly in HSV-infected cells by a viral-specific thymidine kinase to acyclovir-monophosphate.
Controversies in the treatment of cytomegalovirus retinitis: foscarnet versus ganciclovir.: Infect Agents Dis. 1995 Sep;4(3):131-42. Unique Identifier : AIDSLINE MED/96034255; Jabs DA; Wilmer Ophthalmological Institute, Baltimore, Maryland 21205,; USA.; Cytomegalovirus ( CMV ) retinitis is the most common intraocular infection in patients with AIDS. Untreated, CMV retinitis is a binding disease. Ganciclovir, a nucleoside analog, and foscarnet, a pyrophosphate analog, are both effective in controlling CMV retiniti
Pediatric soft tissue infections.: Semin Pediatr Surg. 1995 Nov;4(4):228-33. Unique Identifier : AIDSLINE MED/96141334; Minnick KE; Dillon PW; Pennsylvania State University, Division of Pediatric Surgery,; Hershey Medical Center, Hershery 17033, USA.; Quite often a soft tissue infection in a child may be the primary reason for seeking medical attention or an incidental finding on examination. To identify those infections that may be serious and require further intervention, all those dedicated to the care of children must be familiar with these illnesses and their
Human immunodeficiency virus and acquired immunodeficiency syndrome: recent developments and their implications for pediatric surgeons.: Semin Pediatr Surg. 1995 Nov;4(4):252-61. Unique Identifier : AIDSLINE MED/96141338; Cooper A; Division of Pediatric Surgery, College of Physicians & Surgeons; of Columbia University, Harlem Hospital Center, New York, NY; 10037, USA.; Advances in medical management have enhanced both the quality and the quantity of life currently enjoyed by HIV-infected infants and children. Advances in surgical treatment have complemented these advances and contributed to the improving prognosis of HIV disease in the pediatric population. The resultant aging of th
HIV gp120-specific cell-mediated immune responses in mice after oral immunization with recombinant Salmonella.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):489-95. Unique Identifier : AIDSLINE MED/96142210; Berggren RE; Wunderlich A; Ziegler E; Schleicher M; Duke RC; Looney D; Fang FC; Division of Infectious Diseases, University of Colorado Health; Sciences Center, Denver 80267, USA.; Salmonella is of great interest as a potential human immunodeficiency virus vaccine vector because of its ability to elicit potent mucosal and systemic immune responses when administered orally. To determine whether such a vaccine could elicit an immune response in mice, plasmids expressing HIV gp120-LAI were introduc
Inhibition of HIV-1-induced syncytia formation and infectivity by lipophosphoglycan from Leishmania.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):496-505. Unique Identifier : AIDSLINE MED/96142211; Easterbrook MD; Levy MH; Gomez AM; Turco SJ; Epand RM; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; In HIV-1 infection, the appearance of syncytia-inducing (SI) isolates is associated with a more rapid decline of CD4+ cells and progression to AIDS. Agents that inhibit either virus infection or syncytia formation have the potential to be therapeutically useful. Lipophosphoglycan (LPG), the major glycoconjugate of Lei
Amino acid sequence requirements for the incorporation of the Vpx protein of simian immunodeficiency virus into virion particles.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):506-10. Unique Identifier : AIDSLINE MED/96142212; Park IW; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115, USA.; To investigate the amino acid sequence determinants for the incorporation of Vpx protein into virion particles, several mutations were introduced into the vpx gene of SIVmac239 proviral DNA, and the effects of mutations on the expression and assembly of the Vpx protein were studied. The results show that deletions of
Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):511-21. Unique Identifier : AIDSLINE MED/96142213; Sippy BD; Hofman FM; Wallach D; Hinton DR; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033, USA.; Tumor necrosis factor (TNF)-alpha has been shown to be increased in brain tissue of AIDS patients and may function as a mediator of cerebral damage. We initiated a study to determine the cellular localization and degree of protein and mRNA expression of the two specific TNF-alpha receptors (TNF-Rs), p55 and p75, in br
Evaluation of four alternative methodologies for determination of absolute CD4+ lymphocyte counts. The National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):522-30. Unique Identifier : AIDSLINE MED/96142214; Johnson D; Hirschkorn D; Busch MP; Irwin Memorial Blood Centers, San Francisco, CA 94118, USA.; Standard methods for determining absolute CD3+CD4+ T-lymphocyte concentrations using combined results from flow cytometry and hematology analyzers are expensive and require fresh (
Soluble tumor necrosis factor receptors as surrogate markers for the assessment of zidovudine treatment in asymptomatic HIV-1 infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):531-9. Unique Identifier : AIDSLINE MED/96142215; Godfried MH; van der Poll T; Mulder JW; Weverling GJ; Endert E; Lange JM; Sauerwein HP; Department of Internal Medicine, University of Amsterdam, The; Netherlands.; In untreated, asymptomatic human immunodeficiency virus type 1 (HIV-1) infection, elevated serum concentrations of soluble receptors for tumor necrosis factor (sTNFR) types I and II are associated with progression to AIDS. To assess the utility of sTNFRs as markers for the assessment of antiretroviral treatment, sTNFR
Abnormalities of measles antibody response in human immunodeficiency virus type 1 (HIV-1) infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):540-8. Unique Identifier : AIDSLINE MED/96142216; Brunell PA; Vimal V; Sandu M; Courville TM; Daar E; Israele V; Ahmanson Pediatric Center, Department of Medicine, Cedars-Sinai; Medical Center, Los Angeles, California 90048, USA.; The finding that severe measles occurs in immunized as well as nonimmunized human immunodeficiency virus (HIV)-infected individuals suggests that both immunologic memory and the initial response to measles may be impaired by HIV infection. That the initial response is affected was supported by the finding that post-me
The tolerability and pharmacokinetics of N-butyl-deoxynojirimycin in patients with advanced HIV disease (ACTG 100). The AIDS Clinical Trials Group (ACTG) of the National Institute of Allergy and Infectious Diseases.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):549-53. Unique Identifier : AIDSLINE MED/96142217; Tierney M; Pottage J; Kessler H; Fischl M; Richman D; Merigan T; Powderly W; Smith S; Karim A; Sherman J; et al; Massachusetts General Hospital, Boston 02114, USA.; Twenty-nine patients were enrolled in a phase I dose-escalating tolerance trial of N-butyl-deoxynojirimycin, an alpha-glucosidase I inhibitor that inhibits human immunodeficiency virus (HIV)-1 replication by altering glycosylation of gp120. Dosing was begun at 8 mg/kg/day and subsequent doses were 16, 32, 48, and 64 m
Alcohol, sexual practices, and risk of AIDS among blacks, Hispanics, and whites.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):554-61. Unique Identifier : AIDSLINE MED/96142218; Caetano R; Hines AM; Alcohol Research Group, Western Consortium for Public Health,; Berkeley, California 94709-2176, USA.; The association of alcohol consumption and unsafe sexual behavior known to increase the risk of HIV transmission was examined among blacks, Hispanics, and whites. Data were obtained from a 1990 general population survey on alcohol use that included questions on sexual behavior. Analyses examined sex and ethnic differe
Differences in participation in experimental drug trials among persons with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):562-8. Unique Identifier : AIDSLINE MED/96142219; Diaz T; Chu SY; Sorvillo F; Mokotoff E; Davidson AJ; Samuel MC; Herr M; Doyle B; Frederick M; Fann SA; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA.; To measure participation in experimental drug trials among persons with acquired immunodeficiency syndrome (AIDS), we interviewed 4,604 persons at least 18 years of age who were reported to have AIDS to 11 state and city health departments in the United States . Ten percent reported tha
AIDS knowledge, risk behaviors, and condom use among four groups of female sex workers in Bali, Indonesia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):569-76. Unique Identifier : AIDSLINE MED/96142220; Ford K; Wirawan DN; Fajans P; School of Public Health, University of Michigan, Ann Arbor; 48109-2029, USA.; The objectives of this study were to discover the AIDS knowledge, risk behaviors, and condom use of four groups of female professional sex workers (n = 614). Personal interviews were conducted with women working in low-price brothels, mid-price and high-price houses, and tourist areas. Only 51% of women in the low-pri
Will preventive HIV vaccine efficacy trials be possible with female injection drug users?: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15;10(5):577-85. Unique Identifier : AIDSLINE MED/96142221; Meyers K; Metzger DS; McLellan AT; Navaline H; Sheon AR; Woody GE; University of Pennsylvania/Philadelphia Veterans Medical Center,; Center for Studies of Addiction, USA.; This article examines whether preventive HIV vaccines trials will be viable among female injection drug users (IDUs). Of the 137 women who completed baseline serologic and behavioral assessments, 121 (88%) were seronegative; all enrolled in Project Jumpstart in Philadelphia (PA, U.S.A.), a vaccine preparedness initiat
Development of zidovudine (AZT) resistance in Jurkat T cells is associated with decreased expression of the thymidine kinase (TK) gene and hypermethylation of the 5' end of human TK gene.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):1-9. Unique Identifier : AIDSLINE GENBANK/X54729; Wu S; Liu X; Solorzano MM; Kwock R; Avramis VI; Department of Pediatrics, USC School of Medicine, Childrens; Hospital Los Angeles 90027, USA.; The T-cell line Jurkat E6-1 was rendered resistant to zidovudine ( AZT ) in vitro by exposure to low but gradually increased concentrations of the drug. Biochemical pharmacology studies of [3H]AZT in the AZT-resistant T-cell lines showed a significant r
Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):10-22. Unique Identifier : AIDSLINE MED/96142196; Friborg J; Ladha A; Gottlinger H; Haseltine WA; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de; Medecine, Universite de Montreal, Quebec, Canada.; The human immunodeficiency virus type 1 (HIV-1)-encoded vpu product is a small class 1 integral membrane protein that is phosphorylated by the ubiquitous casein kinase II (CKII) in HIV-1-infected cells. The Vpu protein facilitates the release of budding virions from the surface of infected cells and delays the rate of
Hypercalcemia associated with cytomegalovirus infection in an AIDS patient [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):101-2. Unique Identifier : AIDSLINE MED/96142208; Fallatah S; Halim MA; Ellis ME
Review of invasive cervical cancer cases for AIDS surveillance [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):102-3. Unique Identifier : AIDSLINE MED/96142209; Kelley KF; Smith PF; Mikl J
Neurologic manifestations of AIDS: a comparative study of two populations from Mexico and the United States.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):23-9. Unique Identifier : AIDSLINE MED/96142197; Trujillo JR; Garcia-Ramos G; Novak IS; Rivera VM; Huerta E; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; Neurologic complications associated with human immunodeficiency virus type 1 (HIV-1) infection vary geographically. To understand the pattern of HIV-associated neurologic complications in Mexico, 120 AIDS patients from Mexico City, Mexico, and 500 AIDS patients from Houston, Texas, were studied cross-sectionally and r
Markers and determinants of disease progression in children with HIV infection. The Pediatric AIDS Siena Workshop II.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):30-44. Unique Identifier : AIDSLINE MED/96142198; Pizzo PA; Wilfert CM; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland, USA.
Continuous low-dose interferon-alpha therapy for HIV-related immune thrombocytopenic purpura.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):45-50. Unique Identifier : AIDSLINE MED/96142199; Northfelt DW; Charlebois ED; Mirda MI; Child C; Kaplan LD; Abrams DI; Department of Medicine, University of California, San Francisco; 94143-1270, USA.; Our objective was to examine the efficacy and toxicity of continuous, low-dose interferon-alpha therapy for human immunodeficiency virus-related immune thrombocytopenic purpura (HIV-ITP) in a Phase II clinical trial overseen by a community-based consortium of physicians conducting clinical trials in HIV-related diseas
Bacteremia in hospitalized patients infected with the human immunodeficiency virus: a case-control study of risk factors and outcome.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):51-7. Unique Identifier : AIDSLINE MED/96142200; Fichtenbaum CJ; Dunagan WC; Powderly WG; Department of Internal Medicine, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.; We reviewed all episodes of nonmycobacterial bacteremias in human immunodeficiency virus (HIV)-infected patients from 1990 to 1991 to determine the incidence, risk factors, and outcome. Forty-five patients had a total of 63 episodes of bacteremia (9% of 689 HIV-related hospitalizations). In this cohort, the median CD4
Health insurance and use of medical services by men infected with HIV.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):58-63. Unique Identifier : AIDSLINE MED/96142201; Katz MH; Chang SW; Buchbinder SP; Hessol NA; O'Malley P; Doll LS; AIDS Office, Department of Public Health, San Francisco, CA; 94102-6033, USA.; Among 178 HIV-infected men from the San Francisco City Clinic Cohort (SFCCC), we examined the association between health insurance and use of outpatient services and treatment. For men with private insurance, we also assessed the frequency of avoiding the use of health insurance. Men without private insurance reported
Removal of human immunodeficiency virus by an 0.04-micron membrane filter.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):64-5. Unique Identifier : AIDSLINE MED/96142202; Oshima KH; Comans TW; Highsmith AK; Ades EW; Biological Products Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; We tested the ability of a 0.04-micron nylon membrane filter to remove human immunodeficiency virus (HIV) from tissue culture media containing 10% fetal calf serum. Endpoint titrations of infectious virus (ID50) were performed on lymphocyte cultures. The presence of virus in the cultures was determined using an enzyme
Changes in markers of disease progression in HIV-1 seroconverters: a comparison between cohorts of injecting drug users and homosexual men.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):66-74. Unique Identifier : AIDSLINE MED/96142203; Galai N; Vlahov D; Margolick JB; Chen K; Graham NM; Munoz A; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205, USA.; Comparisons of human immunodeficiency virus (HIV) disease progression between risk groups are difficult primarily because of the long incubation period of acquired immune deficiency syndrome (AIDS) and unknown times of infection. This is believed to be the first study that directly compared changes in T-lymphocyte sub
Incidence proportion of and risk factors for AIDS patients diagnosed with HIV dementia, central nervous system toxoplasmosis, and cryptococcal meningitis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):75-82. Unique Identifier : AIDSLINE MED/96142204; Wang F; So Y; Vittinghoff E; Malani H; Reingold A; Lewis E; Giordano J; Janssen R; School of Public Health, University of California/Berkeley, USA.; We undertook this study to determine the incidence proportion of and risk factors for AIDS patients diagnosed with human immunodeficiency virus (HIV) dementia , central nervous system (CNS) toxoplasmosis, and cryptococcal meningitis. A historical cohort of 487 consecutive inpatients
Male circumcision, sexually transmitted disease, and risk of HIV.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):83-90. Unique Identifier : AIDSLINE MED/96142205; Seed J; Allen S; Mertens T; Hudes E; Serufilira A; Carael M; Karita E; Van de Perre P; Nsengumuremyi F; Projet San Francisco, California, USA.; Our objective was to describe associations among male circumcision, behavioral and demographic variables, ulcerative and nonulcerative sexually transmitted disease (STD), and human immunodeficiency virus (HIV) infection via a cross-sectional study in Kigali, the capital of Rwanda .
HIV/HTLV-I coinfection and clinical grade at diagnosis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):91-5. Unique Identifier : AIDSLINE MED/96142206; Chavance M; Neisson-Vernant C; Quist D; Monplaisir N; Armengaud B; Chout R; INSERM U169, Recherches en Epidemiologie, Villejuif, France.; A total of 963 HIV-infected patients have been identified or followed up in Martinique since 1985. Medical files were used to retrieve information about age, sex, circumstances of diagnosis, HTLV-I status, and HIV clinical grade at
Influence of HIV epidemic on the incidence of Kaposi's sarcoma in Zambian children.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):96-100. Unique Identifier : AIDSLINE MED/96142207; Athale UH; Patil PS; Chintu C; Elem B; Department of Paediatrics and Child Health, University Teaching; Hospital, School of Medicine, University of Zambia, Lusaka,; Zambia.; Acquired immunodeficiency syndrome-associated Kaposi s sarcoma (KS) is well documented in adults. However, very little information is available about KS in the pediatric age group. A retrospectively study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia , to
Picture Story. Three's company.: Nat Struct Biol. 1996 Jan;3(1):23. Unique Identifier : AIDSLINE MED/96164800; Felsenfeld AL
Tattle tales [news]: Nat Struct Biol. 1996 Jan;3(1):8-11. Unique Identifier : AIDSLINE MED/96133721; Sundquist WI
Immune complex transfer enzyme immunoassay that is more sensitive and specific than western blotting for detection of antibody immunoglobulin G to human immunodeficiency virus type 1 in serum with recombinant pol and gag proteins as antigens.: Clin Diagn Lab Immunol. 1995 Sep;2(5):535-41. Unique Identifier : AIDSLINE MED/96089389; Hashida S; Hashinaka K; Nishikata I; Oka S; Shimada K; Saito A; Takamizawa A; Shinagawa H; Yano S; Kojima H; et al; Department of Biochemistry, Miyazaki Medical College, Japan.; Antibody immunoglobulin G (IgG) to human immunodeficiency virus type 1 (HIV-1) in serum was detected by ultrasensitive enzyme immunoassays (immune complex transfer enzyme immunoassays) with recombinant reverse transcriptase (rRT), p17 (rp17) and p24 (rp24) of HIV-1 as antigens and beta-D-galactosidase from Escherichia
Characteristics and clinical significance of a stabilization assay to detect specific antibodies to reverse transcriptase of human immunodeficiency virus.: Clin Diagn Lab Immunol. 1995 Sep;2(5):583-9. Unique Identifier : AIDSLINE MED/96089396; Morita M; Suzuki T; Nakajima K; Shiozawa C; Gill MJ; Hoshino H; Division of Biomedical Research, Kitasato Institute Hospital,; Tokyo, Japan.; Antibodies against reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) have been detected in seropositive subjects by immunoprecipitation, Western immunoblotting, and neutralization assay. Recently, we noticed that the antibodies against RT stabilized RT upon heat inactivation, and we have develo
A manual bead assay for the determination of absolute CD4+ and CD8+ lymphocyte counts in human immunodeficiency virus-infected individuals.: Clin Diagn Lab Immunol. 1995 Sep;2(5):623-5. Unique Identifier : AIDSLINE MED/96089402; Carella AV; Moss MW; Provost V; Quinn TC; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; CD4+ T lymphocytes are currently the most common surrogate marker indicating disease progression in individuals infected with human immunodeficiency virus (HIV). Since the cost of enumerating lymphocyte phenotypes is quite high, an inexpensive bead assay analyzed by light microscopy (cytosphere assay; Coulter Corporat
Adenosine deaminase isoenzyme levels in patients with human T-cell lymphotropic virus type 1 and human immunodeficiency virus type 1 infections.: Clin Diagn Lab Immunol. 1995 Sep;2(5):626-30. Unique Identifier : AIDSLINE MED/96089403; Tsuboi I; Sagawa K; Shichijo S; Yokoyama MM; Ou DW; Wiederhold MD; Department of Immunology, Kurume University School of Medicine,; Japan.; In serum, the enzyme adenosine deaminase (ADA) is known to be divided into two isoenzymes, ADA1 and ADA2, which have different molecular weights and kinetic properties. The present study investigated ADA isoenzyme levels in the sera of patients infected with retroviruses associated with adult T-cell leukemia (ATL), hu
Genetic instability of a MoMLV-based antisense double-copy retroviral vector designed for HIV-1 gene therapy.: Gene Ther. 1995 Nov;2(9):639-46. Unique Identifier : AIDSLINE MED/96129243; Junker U; Bohnlein E; Veres G; Progenesys, Department of Molecular Therapy, Palo Alto, CA 94304,; USA.; We constructed a retroviral vector encoding a mutant tRNA(imet) gene followed by a HIV-1 rev-specific antisense sequence in the U3 region of the 3 long terminal repeat (LTR). This Moloney murine leukemia virus (MoMLV)-based double-copy retroviral vector was used to transduce human lymphoblastoid T-cell lines (CEM, Ju
[Dementias: current situation and future perspectives]: Rev Neurol. 1995 Jan-Feb;23(119):70-6. Unique Identifier : AIDSLINE MED/96085359; Espert R; Bertolin JM; Navarro JF; Gonzalez A; Area de Psicobiologia, Facultad de Psicologia, Universitat de; Valencia.; In this paper, the first one in a series of three complementary papers on dementias, we introduce the concept and evaluate the methods for diagnostic and the data provided by modern epidemiology. The current clinic criteria for the diagnosis of dementias are based on international instructions such as those included i
A serological survey of bovine syncytial virus in Ontario: associations with bovine leukemia and immunodeficiency-like viruses, production records, and management practices.: Can J Vet Res. 1995 Oct;59(4):271-8. Unique Identifier : AIDSLINE MED/96127198; Jacobs RM; Pollari FL; McNab WB; Jefferson B; Department of Pathology, University of Guelph, Ontario.; Of the 920 cows tested, 56.7% showed antiretroviral serological reactivity. Prevalence rates (95% confidence interval) of antiretroviral antibodies among individual dairy cows in Ontario were: BIV 5.5% (4.0-7.0), BLV 25.7% (22.9-28.6), and BSV 39.6% (36.4-42.8). The following percentages of cows showed serological rea
Treating AIDS: hope and despair [letter; comment]: Can Med Assoc J. 1996 Jan 15;154(2):139; discussion 140. Unique Identifier : AIDSLINE MED/96144441; Brown RH
Treating AIDS: hope and despair [letter; comment]: Can Med Assoc J. 1996 Jan 15;154(2):139-40. Unique Identifier : AIDSLINE MED/96144442; Brown MG
Treating AIDS: hope and despair [letter; comment]: Can Med Assoc J. 1996 Jan 15;154(2):140. Unique Identifier : AIDSLINE MED/96144443; Sauls R
A surgeon with AIDS made the most of borrowed time.: Can Med Assoc J. 1996 Jan 15;154(2):223-5. Unique Identifier : AIDSLINE MED/96144455; Robb N; Dr. Orville Messenger and his wife, Dorothy wrote a book, Borrowed Time, which chronicled his decade-long struggle with AIDS. The disease developed following a 1985 blood transfusion. A general and thoracic surgeon who also worked for the Canadian Medical Protective Association, Dr. Messenger wrote the book to raise p
B7.1 expression on tumor cells circumvents the need of professional antigen presentation for in vitro propagation of cytotoxic T cell lines.: Cancer Res. 1996 Jan 1;56(1):11-5. Unique Identifier : AIDSLINE MED/96124868; Iezzi G; Protti MP; Rugarli C; Bellone M; Laboratorio I.A., Istituto Scientifico H San Raffaele, Milano,; Italy.; In vitro propagation of tumor-specific CTLs, to be used for identification of tumor antigens (Ag) and/or adoptive immunotherapy, is hampered by the need of large amounts of professional antigen-presenting cells (APC) used for periodical cycles of restimulation. We evaluated whether RMA T lymphoma cells, stably transfe
Effect of injection of anti-CD4 and anti-CD8 monoclonal antibodies on the development of experimental systemic lupus erythematosus in mice.: Cell Immunol. 1996 Jan 10;167(1):30-7. Unique Identifier : AIDSLINE MED/96139348; Ruiz PJ; Zinger H; Mozes E; Department of Chemical Immunology, Weizmann Institute of Science,; Rehovot, Israel.; Induction of an experimental disease resembling systemic lupus erythematosus (SLE) has been achieved in mice by immunization with a human monoclonal anti-DNA antibody, bearing a common idiotype, designated 16/6 Id. In the present study we used anti-CD4 and anti-CD8 antibodies to modulate the induction and development
Atovaquone inhibits the glucuronidation and increases the plasma concentrations of zidovudine.: Clin Pharmacol Ther. 1996 Jan;59(1):14-21. Unique Identifier : AIDSLINE MED/96152186; Lee BL; Tauber MG; Sadler B; Goldstein D; Chambers HF; Department of Medicine, University of California, San Francisco,; San Francisco General Hospital 94110, USA.; The pharmacokinetic interaction between atovaquone, a 1,4-hydroxynaphthoquinone, and zidovudine was examined in an open, randomized, three-phase crossover study in 14 patients infected with human immunodeficiency virus. Atovaquone (750 mg every 12 hours) and zidovudine (200 mg every 8 hours) were given orally alone an
Pulmonary botryomycosis in a patient with AIDS.: Chest. 1996 Jan;109(1):276-8. Unique Identifier : AIDSLINE MED/96132290; Katapadi K; Pujol F; Vuletin JC; Katapadi M; Pachter BR; Department of Medicine and Pathology, New York Methodist; Hospital, Brooklyn 11215, USA.; We describe the clinical and pathologic findings of the first reported case of pulmonary botryomycosis in a patient with AIDS. Botryomycosis is an uncommon, chronic, suppurative disease that is often mistaken clinically and histologically for a fungal infection. The patient responded to systemic antibiotic therapy.
[Cytomegalovirus disease in the AIDS patient. The current status of therapy and the outlook]: Dtsch Med Wochenschr. 1995 Dec 22;120(51-52):1785-8. Unique Identifier : AIDSLINE MED/96138346; Stoehr A; Plettenberg A; Begemann F; I. Medizinische Abteilung, Allgemeines Krankenhaus St. Georg,; Hamburg.
[The decreasing HIV-1 seroprevalence in young adults in a rural region of Uganda]: Dtsch Med Wochenschr. 1995 Dec 22;120(51-52):1804-5. Unique Identifier : AIDSLINE MED/96163222
Cervical intraepithelial neoplasia and human papillomavirus related lesions of the genital tract in HIV positive and negative women.: Eur J Gynaecol Oncol. 1995;16(5):410-7. Unique Identifier : AIDSLINE MED/96076311; Branca M; Delfino A; Rossi E; Giacomini G; Leoncini L; Riti MG; Morosini PL; Laboratory of Epidemiology and Biostatistic, National Health; Institute, Rome, Italy.; Two hundred and twenty one women at high risk for HIV (intravenous drug users and/or those with infected partners) were investigated, through a self-filled questionnaire and gynaecological examination, to define the relationship between genital Human Papilloma Virus (HPV) infections, preneoplastic cervical intraepithe
AIDS: awareness and blood handling practices of health care workers in Lagos, Nigeria.: Eur J Epidemiol. 1995 Aug;11(4):425-30. Unique Identifier : AIDSLINE MED/96058559; Odujinrin OM; Adegoke OA; Department of Community Health, College of Medicine, University; of Lagos, Nigeria.; A questionnaire survey of 260 health care workers from 13 randomly selected health care facilities was undertaken. Their knowledge, attitude, belief and blood handling practices regarding HIV/AIDS were enquired about. Virtually all (99.0%) respondents had heard about AIDS but only 57.0% had seen an AIDS patient before
Pathogenic Nocardia isolated from clinical specimens including those of AIDS patients in Thailand.: Eur J Epidemiol. 1995 Oct;11(5):507-12. Unique Identifier : AIDSLINE MED/96139643; Poonwan N; Kusum M; Mikami Y; Yazawa K; Tanaka Y; Gonoi T; Hasegawa S; Konyama K; Department of Medical Sciences, National Institute of Health,; Nonthaburi, Thailand.; Forty strains of nocardioform microorganisms were isolated as clinical specimens including several from AIDS patients in Thailand . Among them, 37 strains were found to belong to the genus Nocardia. Our identification studies revealed that most of the strains (25 strains) belong t
Completeness of AIDS reporting and quality of AIDS death certification in Tuscany (Italy): a linkage study between surveillance system of cases and death certificates.: Eur J Epidemiol. 1995 Oct;11(5):513-7. Unique Identifier : AIDSLINE MED/96139644; Barchielli A; Buiatti E; Galanti C; Giovannetti L; Acciai S; Lazzeri V; Epidemiology Unit, Centre for Study and Prevention of Cancer,; Florence, Italy.; In Italy , the AIDS cases defined according to the CDC criteria are reported to the National AIDS Registry (RAIDS, compulsory surveillance system). The aim of the present study is to evaluate the completeness of AIDS cases reported and the quality of AIDS death certification in an It
Survival differences in Austrian patients with the acquired immunodeficiency syndrome.: Eur J Epidemiol. 1995 Oct;11(5):519-26. Unique Identifier : AIDSLINE MED/96139645; Zangerle R; Reibnegger G; Klein JP; Department of Dermatology and Venerology, University of; Innsbruck, Austria.; We investigated the association of clinical and demographic factors on survival of the 901 AIDS cases diagnosed until 31 December 1992 and reported to the Austrian Health Authorities up to 20 January 1994. The overall estimated median survival of patients with AIDS increased substantially from 8 months in 1987 to 16 m
Human T-cell leukemia virus type II infection among high risk groups and its influence on HIV-1 disease progression.: Eur J Epidemiol. 1995 Oct;11(5):527-33. Unique Identifier : AIDSLINE MED/96139646; Giacomo M; Franco EG; Claudio C; Carlo C; Anna DA; Anna D; Franco F; Cattedra di Malattie Infettive, Universita degli Studi di Parma,; Italy.; The prevalence and the risk factors of the human T-cell leukemia virus type I/II (HTLV-I/II) infection were evaluated among 552 individuals at high risk for HIV-1. HTLV infections showed a low (1.6%) prevalence, were restricted to intravenous drug addicts and were due to HTLV-II alone. Moreover, in order to weigh the
Seroconversion to HBV associated with seroconversion to HIV in a cohort of intravenous drug misusers in Turin, Italy.: Eur J Epidemiol. 1995 Oct;11(5):535-9. Unique Identifier : AIDSLINE MED/96139647; Sinicco A; Fora R; Sciandra M; Raiteri R; Institute of Infectious Diseases, University of Turin, Italy.; Between March 1986 and March 1994, the seroconversion to HBV associated to the seroconversion to HIV was investigated in 120 HIV seroconverters drawn from 2368 i.v. drug misusers screened for HIV, HBV and STDs. Among the 185 individuals susceptible to HIV and HBV at intake (41/120 HIV seroconverters and 144/364 HIV-ne
Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM.: FEBS Lett. 1995 Dec 27;377(3):413-8. Unique Identifier : AIDSLINE MED/96140558; Bodor J; Walker W; Flemington E; Spetz AL; Habener JF; Laboratory of Molecular Endocrinology, Massachusetts General; Hospital (WEL320), Howard Hughes Medical Institute, Boston 02114,; USA.; Nuclear proteins of the human peripheral blood T lymphocytes that bind to the CREs located within three 21-bp repeat enhancers of the HTLV-I promoter belong to the CREB/CREM family of bZIP transcription factors. It has been shown previously that Tax enhances transactivation of these CREs by direct interactions with th
Spectroscopic study of an HIV-1 capsid protein major homology region peptide analog.: FEBS Lett. 1996 Jan 2;378(1):43-7. Unique Identifier : AIDSLINE MED/96140705; Clish CB; Peyton DH; Barklis E; Department of Chemistry, Portland State University, OR; 97207-0751, USA.; The capsid (CA) domain of retroviral Gag proteins possesses one subdomain, the major homology region (MHR), which is conserved among nearly all avian and mammalian retroviruses. While it is known that the mutagenesis of residues in the MHR will impair virus infectivity, the precise structure and function of the MHR is
[Chronic diarrhea and Cryptosporidium in diabetic patients with normal lymphocyte subpopulation. 2 case reports]: Gac Med Mex. 1995 Mar-Apr;131(2):219-22. Unique Identifier : AIDSLINE MED/96137323; Trevino-Perez S; Luna-Castanos G; Matilla-Matilla A; Nieto-Cisneros L; Servicio de Medicina Intema del Hospital General de Zona No. 1; Gabriel Mancera, Mexico, D.F.; Two cases of diabetic patients with normal TCD4+ cell count with chronic diarrhoea and Cryptosporidium are described herein. In both cases serologic tests for HIV were negative. The fact that these patients developed a pathology usually seen in presence of low TCD4+ cell counts suggests that some immune defect other t
Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea.: Gut. 1995 Nov;37(5):623-9. Unique Identifier : AIDSLINE MED/96148575; Keating J; Bjarnason I; Somasundaram S; Macpherson A; Francis N; Price AB; Sharpstone D; Smithson J; Menzies IS; Gazzard BG; Department of Medicine, Chelsea and Westminster Hospital, London.; Intestinal function is poorly defined in patients with HIV infection. Absorptive capacity and intestinal permeability were assessed using 3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose in 88 HIV infected patients and the findings were correlated with the degree of immunosuppression (CD4 counts), diarrhoea,
H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytes.: Infect Immun. 1996 Feb;64(2):452-9. Unique Identifier : AIDSLINE MED/96145063; Laochumroonvorapong P; Paul S; Elkon KB; Kaplan G; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, New York, USA.; Mycobacterium avium-M. intracellulare, an intracellular parasite of mononuclear phagocytes, rarely causes disease in immunocompetent individuals. In contrast, in human immunodeficiency virus type 1-infected patients, M. avium-M. intracellulare can infect almost every tissue and organ. This suggests that immunocompeten
Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus.: Infect Immun. 1996 Feb;64(2):466-71. Unique Identifier : AIDSLINE MED/96145065; De Bernardis F; Chiani P; Ciccozzi M; Pellegrini G; Ceddia T; D'Offizzi G; Quinti I; Sullivan PA; Cassone A; Department of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.; Isolates of Candida albicans from the oral cavities of subjects at different stages of human immunodeficiency virus (HIV) infection or uninfected controls were examined for (i) production of aspartic proteinase(s), a putative virulence-associated factor(s); (ii) the presence in the fungal genome of two major genes (SA
A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice.: Infect Immun. 1996 Feb;64(2):535-41. Unique Identifier : AIDSLINE MED/96145076; Jacobs P; Radzioch D; Stevenson MM; Institute of Parasitology, McGill University, Ste. Anne de; Bellevue, Montreal, Quebec, Canada.; We investigated the kinetics of tissue-specific mRNA expression and systemic production of tumor necrosis factor alpha (TNF-alpha) and the kinetics of splenic expression of mRNAs of gamma interferon (INF-gamma) and interleukin-4 (IL-4), cytokines that may regulate TNF-alpha production, during the early phase of blood-
Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite.: Infect Immun. 1996 Feb;64(2):557-62. Unique Identifier : AIDSLINE MED/96145079; Morrison WI; MacHugh ND; Lalor PA; Institute for Animal Health, Compton, United Kingdom.; Theileria parva has been shown to infect and transform B cells and T cells at similar frequencies in vitro. However, the majority of parasitized cells in the tissues of infected cattle are alpha/beta T cells. The aim of this study was to determine whether the cell type infected with T. parva influenced the pathogenici
Strenuous exercise and immunological changes: a multiple-time-point analysis of leukocyte subsets, CD4/CD8 ratio, immunoglobulin production and NK cell response.: Int J Sports Med. 1995 Oct;16(7):466-74. Unique Identifier : AIDSLINE MED/96128797; Shek PN; Sabiston BH; Buguet A; Radomski MW; Defence and Civil Institute of Environmental Medicine, North; York, Ontario, Canada.; This study was designed to examine the impact of exhaustive endurance exercise on a number of immune parameters of physically fit male subjects (VO2max 66.5 +/- 5.3 ml/min/kg) who performed treadmill exercise at 65% of their VO2max for 120 min. Serial blood samples were taken before, during and after exercise and chan
Use of AIDS surveillance data to describe subepidemic dynamics.: Int J Epidemiol. 1995 Aug;24(4):804-12. Unique Identifier : AIDSLINE MED/96022686; Cantoni M; Cozzi Lepri A; Grossi P; Pezzotti P; Rezza G; Verdecchia A; Laboratory of Epidemiology and Biostatistics, Istituto Superiore; di Sanita, Rome, Italy.; BACKGROUND. Official reports on AIDS surveillance mainly consist of absolute numbers of AIDS cases or cumulative incidence rates. More detailed analyses focusing on the clusters of subepidemics within Italy seemed necessary for a better understanding and more accurate description of
Impact on sexually transmitted disease spread of increased condom use by young females, 1987-1992.: Int J Epidemiol. 1995 Aug;24(4):813-20. Unique Identifier : AIDSLINE MED/96022687; Stigum H; Magnus P; Veierod M; Bakketeig LS; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.; BACKGROUND. Sexual behaviour data are crucial for understanding the spread of sexually transmitted diseases (STD). Over a period (1987-1992) in which the HIV epidemic increased public awareness of safe sexual practices, we describe predictors of condom use, changes in condom use over time, and the estimated effects of
Managing occupational HIV exposures: a Canadian study.: Int J Nurs Stud. 1995 Oct;32(5):493-505. Unique Identifier : AIDSLINE MED/96122116; Reutter LI; Northcott HC; Faculty of Nursing, University of Alberta, Edmonton, Canada.; The findings reported in this paper are part of a larger study that explored how nurses cope with the risk of acquiring HIV infection while caring for persons with AIDS (PWAs). The data were collected through in-depth interviews with 13 nurses who cared for PWAs in a large Western Canadian hospital. Seven of these nur
Paradoxic effect of anti-CD4 therapy on lacrimal gland disease in MRL/Mp-lpr/lpr mice.: Invest Ophthalmol Vis Sci. 1996 Jan;37(1):246-50. Unique Identifier : AIDSLINE MED/96142192; Jabs DA; Burns WH; Prendergast RA; Department of Ophthalmology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; PURPOSE. MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop lacrimal gland inflammatory lesions and are a model for the human disease Sjogren s syndrome. Therapy with monoclonal antibodies (mAb) to CD4 ameliorates the autoimmune renal, vasculitic, and intraocular inflammatory lesions in MRL/lpr mice. The effect of an
Cataractogenesis in transgenic mice containing the HIV-1 protease linked to the lens alpha A-crystallin promoter.: J Biol Chem. 1996 Jan 5;271(1):425-31. Unique Identifier : AIDSLINE MED/96132938; Tumminia SJ; Jonak GJ; Focht RJ; Cheng YS; Russell P; Laboratory of Mechanisms of Ocular Diseases, National Eye; Institute, National Institues of Health, Bethesda, Maryland; 20892, USA.; Several lines of transgenic mice were generated with either active or inactive forms of the human immunodeficiency virus type 1 (HIV-1) protease gene under the control of the mouse lens alpha A-crystallin promoter. Mice bearing the inactive protease coding sequence displayed no gross abnormalities in the lens, while m
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.: J Biol Chem. 1996 Jan 5;271(1):97-103. Unique Identifier : AIDSLINE MED/96132888; Otteken A; Moss B; Laboratory of Viral Diseases, NIAID, National Institutes of; Health, Bethesda, Maryland 20892, USA.; The ubiquitous eukaryotic protein calreticulin has been detected in a wide variety of different cell types. Recently, calreticulin was found to bind in vitro to a number of proteins isolated from the endoplasmic reticulum. In addition, calreticulin has sequence similarities with the molecular chaperone calnexin. These
The immune profile of multiple sclerosis: T-lymphocyte effects predominate over all other factors in cyclophosphamide-treated patients.: J Neuroimmunol. 1995 Dec 31;63(2):133-42. Unique Identifier : AIDSLINE MED/96133572; Strauss K; Hulstaert F; Deneys V; Mazzon AM; Hannet I; De Bruyere M; Reichert T; Sindic CJ; Becton Dickinson Immunocytometry Systems, Erembodegem-Aalst,; Belgium.; It is widely believed that multiple sclerosis is a T-cell mediated autoimmune disease associated with abnormalities in immunoregulation. This large, prospective study evaluated the lymphocyte immunophenotypic profile of 246 MS patients, divided clinically into a remitting/relapsing group (n = 176) and a progressive gr
Mouse microglial cell lines differing in constitutive and interferon-gamma-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells.: J Neuroimmunol. 1995 Dec 31;63(2):163-74. Unique Identifier : AIDSLINE MED/96133576; Walker WS; Gatewood J; Olivas E; Askew D; Havenith CE; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 3810, USA.; We developed a panel of non-virus transformed cell lines derived from individual microglial precursors residing in the brains of normal mice. These colony stimulating factor-1-dependent cell lines are B7-1+ (CD80), Mac-1+, Mac-2+, Mac-3+, CD45+, MHC class I+, colony stimulating factor-1 receptor+, and they ingest anti
Effects of short-term dexamethasone treatment during pregnancy on the development of the immune system and the hypothalamo-pituitary adrenal axis in the rat.: J Neuroimmunol. 1995 Dec 31;63(2):183-91. Unique Identifier : AIDSLINE MED/96133578; Bakker JM; Schmidt ED; Kroes H; Kavelaars A; Heijnen CJ; Tilders FJ; van Rees EP; Department of Cell Biology and Immunology, Faculty of Medicine,; Vrije Universiteit, Amsterdam, Netherlands.; The effects of glucocorticoid (GC) treatment on the mature immune and neuroendocrine system are known to be reversible. However, prenatal GC exposure may have irreversible consequences on the development of the newborn. In this study, possible long-lasting effects of short-term prenatal GC treatment were examined on t
The prevalence of grandmothers as primary caregivers in a poor pediatric population.: J Community Health. 1995 Oct;20(5):383-401. Unique Identifier : AIDSLINE MED/96122357; Joslin D; Brouard A; Department of Community Health, William Paterson College of New; Jersey, Wayne 07470, USA.; In the wake of the HIV/AIDS and crack cocaine epidemics, poor urban communities face growing numbers of older adults, largely grandmothers, who have become surrogate parents to children orphaned by these epidemics. This study is the first in the United States to determine the prevalenc
Where have all the autopsies gone? A proposal for a centralized autopsy service.: J Community Health. 1995 Oct;20(5):441-6. Unique Identifier : AIDSLINE MED/96122361; Mitchell EK; Prior JT; State University of New York, Health Science Center at Syracuse; 13210, USA.; A litany of reasons have been advanced to account for the decrease in hospital autopsy rates. Increased attention has recently been centered on the difficulty hospital and medical examiner morgues are encountering in controlling infectious disease and attempting to comply with federal and state environmental regulator
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.: J Immunol Methods. 1995 Dec 15;188(1):117-28. Unique Identifier : AIDSLINE MED/96140787; Prussin C; Metcalfe DD; Allergic Diseases Section, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892-1888, USA.; Recently, there have been several reports demonstrating improvements in the flow cytometric detection of intracellular cytokines. These advances, although significant, have not yielded techniques that have easily been translated into broad use. To address this issue, we have coupled a fixation and permeabilization met
Stable transfection of cloned murine T helper cells.: J Immunol Methods. 1995 Dec 15;188(1):139-46. Unique Identifier : AIDSLINE MED/96140789; Will A; Rollinghoff M; Gessner A; Institut fur Klinische Mikrobiologie und Immunologie,; Universitat Erlangen-Nurberg, Erlangen, Germany.; Here we describe a protocol for the stable transfection of murine T helper (Th) cells and long term culture of the resulting transfectants. The electroporation protocol was established for the murine Th2 clone L1/1 by testing different parameters determining the electric field (capacitance, voltage, single or twin pul
Detection of intracellular HIV-1 Rev protein by flow cytometry.: J Immunol Methods. 1995 Dec 27;188(2):187-95. Unique Identifier : AIDSLINE MED/96144820; Rigg RJ; Dando JS; Escaich S; Plavec I; Bohnlein E; Progenesys, Palo Alto, CA 94304, USA.; The Rev trans-activator protein plays a pivotal role in human immunodeficiency virus type 1 (HIV-1) replication by allowing expression of the viral structural proteins. We have developed a protocol to quantitatively assay intracellular steady state levels of Rev Ag (Rev wild type and RevM10 proteins) by flow cytometry
Acute Sjogren-like syndrome as the first manifestation of a generalized CMV infection in a patient with AIDS.: J Laryngol Otol. 1995 Nov;109(11):1113-4. Unique Identifier : AIDSLINE MED/96142703; Van Vooren JP; Farber CM; Daelemans P; Delforge ML; Liesnard C; Department of Immunodeficiency, Universite Libre de Bruxelles,; Hopital Erasme, Belgium.; We report the first case of generalized cytomegalovirus ( CMV ) disease in an AIDS patient who presented with an acute Sjogren-like syndrome and was diagnosed by parotid gland biopsy. All symptoms disappeared after a few days o
Stridor in patients with HIV infection.: J Laryngol Otol. 1995 Dec;109(12):1197-9. Unique Identifier : AIDSLINE MED/96150443; Laing RB; Wardrop PJ; Welsby PD; Brettle RP; Regional Infectious Diseases Unit, City Hospital, Edinburgh, UK.; The immunodeficiency which results from HIV infection is associated with a range of opportunistic infections and tumors which may present with the symptoms of upper airways disease. This paper presents three cases of stridor from different causes in patients with HIV infection, all of whom recovered following treatmen
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.: J Exp Med. 1996 Jan 1;183(1):215-25. Unique Identifier : AIDSLINE MED/96136764; Spira AI; Marx PA; Patterson BK; Mahoney J; Koup RA; Wolinsky SM; Ho DD; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; We used the simian immunodeficiency virus (SIV)/rhesus macaque model to study events that underlie sexual transmission of human immunodeficiency virus type 1 (HIV-1). Four female rhesus macaques were inoculated intravaginally with SIVmac251, and then killed 2, 5, 7, and 9 d later. A technique that detected polymerase
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.: J Exp Med. 1996 Jan 1;183(1):249-59. Unique Identifier : AIDSLINE MED/96136767; Leitenberg D; Novak TJ; Farber D; Smith BR; Bottomly K; Howard Hughes Medical Institute, Section of Immunobiology, Yale; University School of Medicine, New Haven, Connecticut 06510, USA.; The CD45 tyrosine phosphatase plays an important role in regulating T lymphocyte activation, but the function of the different isoforms of CD45 is not known. T cell transfectants have been prepared that express individual CD45 isoforms in cells with a well-defined T cell receptor (TCR) from the D10 T helper 2 clone. W
Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55).: J Exp Med. 1996 Jan 1;183(1):307-10. Unique Identifier : AIDSLINE MED/96136775; Stoiber H; Pinter C; Siccardi AG; Clivio A; Dierich MP; Institut fur Hygiene, Ludwig Boltzmann Institut fur AIDS; Forschung, Innsbruck, Austria.; Activation of the human complement system leads to complement deposition on human immunodeficiency virus (HIV) and HIV-infected cells without causing efficient complement-mediated lysis. Even in the presence of HIV-specific antibodies, only a few particles are destroyed, demonstrating that HIV is intrinsically resista
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo [see comments]: J Exp Med. 1996 Jan 1;183(1):317-22. Unique Identifier : AIDSLINE MED/96136777; Paglia P; Chiodoni C; Rodolfo M; Colombo MP; Division of Experimental Oncology D, Istituto Nazionale per lo; Studio e la Cura dei Tumori, Milano, Italy.; The priming of an immune response against a major histocompatibility complex class I-restricted antigen expressed by nonhematopoietic cells involves the transfer of that antigen to a host bone marrow-derived antigen presenting cell (APC) for presentation to CD8+ T lymphocytes. Dendritic cells (DC), as bone marrow-deri
HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.: J Exp Med. 1996 Jan 1;183(1):39-48. Unique Identifier : AIDSLINE MED/96136746; Corbeil J; Tremblay M; Richman DD; Department of Medicine, University of California, San Diego, La; Jolla 92093-0679, USA.; The roles of the CD4 receptor and the src kinase p56lck were examined in the process of HIV-induced apoptosis of CD4+ T lymphocytes. The presence of the CD4 cytoplasmic tail was found to be essential in delivering an apoptotic signal, and interaction of CD4 with p56lck potentiated HIV-induced apoptosis. Apoptosis, but
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.: J Exp Med. 1996 Jan 1;183(1):67-76. Unique Identifier : AIDSLINE MED/96136749; Wong FS; Visintin I; Wen L; Flavell RA; Janeway CA Jr; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut 06510, USA.; T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate sp
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines [see comments]: J Exp Med. 1996 Jan 1;183(1):87-97. Unique Identifier : AIDSLINE MED/96136751; Zitvogel L; Mayordomo JI; Tjandrawan T; DeLeo AB; Clarke MR; Lotze MT; Storkus WJ; Department of Surgery, University of Pittsburgh, Pennsylvania; 15261, USA.; Antigen presentation by host dendritic cells (DC) is critical for the initiation of adaptive immune responses. We have previously demonstrated in immunogenic murine tumor models that bone marrow (BM)-derived DC pulsed ex vivo with synthetic tumor-associated peptides, naturally expressed by tumor cells, serve as effect
Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor beta 1.: J Exp Med. 1996 Jan 1;183(1):99-108. Unique Identifier : AIDSLINE MED/96136752; Zauli G; Vitale M; Gibellini D; Capitani S; Institute of Human Anatomy, University of Ferrara, Italy.; Human CD34+ hematopoietic progenitor cells, stringently purified from the peripheral blood of 20 normal donors, showed an impaired survival and clonogenic capacity after exposure to either heat-inactivated human immunodeficiency virus (HIV) 1 (strain IIIB) or cross-linked envelope gp120. Cell cycle analysis, performed
HTLV infection among Italian intravenous drug users and North African subjects detected by the polymerase chain reaction and serological methods.: J Med Virol. 1995 Sep;47(1):10-5. Unique Identifier : AIDSLINE MED/96048315; Colombo E; Magistrelli C; Mendozzi E; Cattaneo E; Achilli G; Ferrante P; Institute of Medical Microbiology, Istituto di Ricovero e Cura a; Carattere Scientifico (IRCCS), S. Maria Nascente, University of; Milan, Italy.; Six hundred intravenous drug users (IVDUs) and two hundred North Africans were screened for human T-cell leukemia virus (HTLV) antibodies using several serological methods. Eighteen of the eighty-two HTLV-seropositive individuals were also tested by the polymerase chain reaction-DNA enzyme immunoassay (PCR-DEIA), a no
Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors.: J Med Virol. 1995 Sep;47(1):105-11. Unique Identifier : AIDSLINE MED/96048330; Luppi M; Barozzi P; Maiorana A; Marasca R; Trovato R; Fano R; Ceccherini-Nelli L; Torelli G; Department of Medical Sciences, University of Modena, Italy.; In an attempt to study the frequency and distribution of human herpesvirus-6 (HHV-6) infection both in normal and neoplastic brain tissues in vivo, polymerase chain reaction was used to look for HHV-6 genomes: 1) in samples, obtained at necropsy, from different regions of the brain of immunocompetent adult subjects an
Use of the polymerase chain reaction to detect genomes of human immunodeficiency virus and cytomegalovirus in post-mortem tissues.: J Med Virol. 1995 Sep;47(1):23-8. Unique Identifier : AIDSLINE MED/96048317; Webster A; McLaughlin JE; Johnson MA; Emery VC; Griffiths PD; Division of Pathology and Communicable Diseases, Royal Free; Hospital School of Medicine, London, United Kingdom.; The polymerase chain reaction (PCR) was used to amplify a 149 base-pair region of the cytomegalovirus ( CMV ) genome and a 551 base-pair region of the HIV-1 proviral long terminal repeat (LTR) present in DNA extracted from post
Quantitation of human cytomegalovirus genomes in the brain of AIDS patients.: J Med Virol. 1995 Sep;47(1):70-82. Unique Identifier : AIDSLINE MED/96048325; Kuhn JE; Wendland T; Eggers HJ; Lorentzen E; Wieland U; Eing B; Kiessling M; Gass P; Institut fuer Virologie, Universitaet zu Koeln, Federal Republic; of Germany.; Human cytomegalovirus (HCMV) is one of the major pathogens causing neurologic disease in the immunocompromised host. A competitive nested polymerase chain reaction (PCR) was used to determine DNA load, distribution, and sequence variability of HCMV genomes in the brain of AIDS pati
Serum anti-p24 antibody concentration has a predictive value on the decrease of CD4 lymphocyte count higher than acid-dissociated p24 antigen.: J Med Virol. 1995 Sep;47(1):87-91. Unique Identifier : AIDSLINE MED/96048327; Morand-Joubert L; Bludau H; Lerable J; Petit JC; Lefrere JJ; Service de Bacterio-Virologie, Hopital Saint-Antoine, Paris,; France.; We studied the prognostic value on the decrease of CD4 lymphocyte count of anti-p24 antibody (ab) titer and compared this value with that of polyclonal and monoclonal p24 (ag) titer before and after immune complex dissociation (ICD); 53 human immunodeficiency virus (HIV)-infected patients having CD4+ counts above 400/
Comparison of human immunodeficiency virus biological phenotypes isolated from cerebrospinal fluid and peripheral blood.: J Med Virol. 1995 Sep;47(1):92-6. Unique Identifier : AIDSLINE MED/96048328; Peeters MF; Colebunders RL; Van den Abbeele K; Nys PC; Goeman J; Colans P; Geerts Y; Van der Groen G; Department of Infection and Immunity, University Hospital; Antwerp, Belgium.; Quantitative human immunodeficiency virus (HIV) cultures were carried out on cerebrospinal fluid (CSF), peripheral blood mononuclear cells (PBMCs), and plasma from patients with HIV in order to compare the infectious HIV load. The HIV strains isolated were studied for syncytium-inducing (SI) capacity, using the MT-2 c
PCR detection of JC virus DNA in brain tissue from patients with and without progressive multifocal leukoencephalopathy.: J Med Virol. 1995 Nov;47(3):219-25. Unique Identifier : AIDSLINE MED/96129548; Ferrante P; Caldarelli-Stefano R; Omodeo-Zorini E; Vago L; Boldorini R; Costanzi G; Institute of Medical Microbiology, University of Milan, Italy.; Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, which is thought to be a result of the reactivation of JC virus (JCV), a human polyomavirus. The disease occurs in individuals with immunosuppression and in recent years there has been an increase in PML cases du
Hepatitis C virus infection in an HIV-positive population in Normandy: antibodies, HCV RNA and genotype prevalence.: J Med Virol. 1995 Nov;47(3):231-6. Unique Identifier : AIDSLINE MED/96129550; Mendel I; Clotteau L; Lambert S; Buffet-Janvresse C; Virology Department, Charles Nicolle Hospital, University of; Rouen, France.; The prevalence and the characteristics of hepatitis C virus infection (HCV) in 161 HIV-positive patients were studied. HCV seroprevalence was determined by enzyme immunoassay and recombinant immunoblot assay (RIBA). Two different reverse transcriptase polymerase chain reaction (RT-PCR) methods were also used to test t
Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients.: J Med Virol. 1995 Nov;47(3):237-44. Unique Identifier : AIDSLINE MED/96129551; Sarasini A; Baldanti F; Furione M; Percivalle E; Brerra R; Barbi M; Gerna G; Viral Diagnostic Service, University of Pavia, Istituto di; Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo,; Italy.; Four human cytomegalovirus (HCMV) isolates from four different AIDS patients treated with both ganciclovir and foscarnet and not responding clinically to antiviral treatment, were studied in order to verify the occurrence of double resistance to both drugs, and to define whether si
Biological phenotypes of HIV-1 subtypes A and B strains of diverse origins.: J Med Virol. 1995 Nov;47(3):278-84. Unique Identifier : AIDSLINE MED/96129557; Nkengasong JN; Peeters M; Zhong P; Willems B; Janssens W; Heyndrickx L; Fransen K; Ndumbe PM; Gershy-Damet GM; Nys P; et al; Institute of Tropical Medicine, Antwerp, Belgium.; The identification of specific biologic phenotypic traits that can be correlated with different HIV-1 genetic subtypes was sought. The genetic subtypes were determined by either sequencing (Cameroonian strains, n = 18) or by the heteroduplex mobility assay (HMA) (Belgian strains, n = 21 and Ivorian strains, n = 25). S
Short-term stability of HIV provirus levels in the peripheral blood of HIV-infected individuals.: J Med Virol. 1995 Nov;47(3):292-7. Unique Identifier : AIDSLINE MED/96129559; Paul DB; Kuhns MC; McNamara AL; Pottage JC Jr; Spear GT; Department of Immunology/Microbiology, Rush Presbyterian St.; Luke's Medical Center, Chicago, IL 60612, USA.; Changes in viral load have been reported to reflect disease progression or response to therapy; however, the stability of HIV DNA levels in HIV-infected individuals has not been extensively studied. Cellular HIV DNA levels in infected individuals were evaluated over a short time period to determine degree of variabili
Sexually transmitted diseases: current and emerging concerns.: J Obstet Gynecol Neonatal Nurs. 1995 Oct;24(8):743-58. Unique Identifier : AIDSLINE MED/96122615; Youngkin EQ; Department of Maternal Child Nursing, School of Nursing, Virginia; Commonwealth University, Richmond 23298-0567, USA.; Sexually transmitted diseases (STDs) are epidemic today, with the highest prevalence being among adolescents and young adults. If any decrease in incidence is to occur, nurses must make a determined effort to identify at-risk individuals and groups and empower them through teaching and counseling about strategies of p
Frequent recurrence and persistence of varicella-zoster virus infections in children infected with human immunodeficiency virus type 1.: J Pediatr. 1996 Jan;128(1):52-7. Unique Identifier : AIDSLINE MED/96144594; von Seidlein L; Gillette SG; Bryson Y; Frederick T; Mascola L; Church J; Brunell P; Kovacs A; Deveikis A; Keller M; Department of Pediatrics, University of California at Los; Angeles, Childrens Hospital Los Angeles, USA.; OBJECTIVE: To examine complications and treatment of varicella-zoster virus (VZV) infections in children infected with human immunodeficiency virus type 1 (HIV-1). METHODS: Cases of VZV infection were identified retrospectively by reports to the department of health services and review of medical charts. The CD4+ cell
Natural history of somatic growth in infants born to women infected by human immunodeficiency virus. Women and Infants Transmission Study Group.: J Pediatr. 1996 Jan;128(1):58-69. Unique Identifier : AIDSLINE MED/96144595; Moye J Jr; Rich KC; Kalish LA; Sheon AR; Diaz C; Cooper ER; Pitt J; Handelsman E; Pediatric, Adolescent, and Maternal AIDS Branch, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD 20892-7510, USA.; OBJECTIVE: To evaluate the nature and magnitude of the effect of congenitally or perinatally acquired human immunodeficiency virus (HIV) infection on somatic growth from birth through 18 months of age. STUDY DESIGN: Anthropometry was performed serially in 282 term infants born to HIV-infected women in a multicenter pr
Thyroid abnormalities in children infected with human immunodeficiency virus.: J Pediatr. 1996 Jan;128(1):70-4. Unique Identifier : AIDSLINE MED/96144596; Hirschfeld S; Laue L; Cutler GB Jr; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland 20892, USA.; OBJECTIVE: To study thyroid function in children infected with human immunodeficiency virus (HIV) and determine whether there are correlates of thyroid dysfunction with disease progression. STUDY DESIGN: Total and free thyroxine, triiodothyronine, reverse triiodothyronine, thyrotropin, and thyroxine binding globulin (
Inhibition and catalytic mechanism of HIV-1 aspartic protease.: J Mol Biol. 1996 Jan 19;255(2):321-46. Unique Identifier : AIDSLINE MED/96150306; Silva AM; Cachau RE; Sham HL; Erickson JW; Structural Biochemistry Program, National Cancer Institute,; Frederick, MD 21702, USA.; The structure of the HIV-1 protease in complex with a pseudo-C2 symmetric inhibitor, which contains a central difluoroketone motif, has been determined with X-ray diffraction data extending to 1.7 A resolution. The electron density map clearly indicates that the inhibitor is bound in a symmetric fashion as the hydrate
Evidence for a second function of the MA sequence in the Rous sarcoma virus Gag protein.: J Virol. 1996 Feb;70(2):1016-26. Unique Identifier : AIDSLINE MED/96135214; Parent LJ; Wilson CB; Resh MD; Wills JW; Department of Medicine, Pennsylvania State University College of; Medicine, Hershey 17033, USA.; During retrovirus assembly, Gag proteins bind to the inner leaflet of the plasma membrane to initiate the budding process. The molecular basis of this protein-lipid interaction is poorly understood. For the human, immunodeficiency virus type 1 Gag protein, we recently reported that the membrane-binding domain resides
Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.: J Virol. 1996 Feb;70(2):1027-32. Unique Identifier : AIDSLINE MED/96135215; Gallay P; Stitt V; Mundy C; Oettinger M; Trono D; Infectious Disease Laboratory, Salk Institute for Biological; Studies, La Jolla, California 92037, USA.; The interaction of the human immunodeficiency virus type 1 (HIV-1) nucleoprotein complex with the cell nuclear import machinery is necessary for viral replication in macrophages and for the establishment of infection in quiescent T lymphocytes. The karyophilic properties of two viral proteins, matrix (MA) and Vpr, are
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.: J Virol. 1996 Feb;70(2):1072-9. Unique Identifier : AIDSLINE MED/96135220; von Herrath MG; Yokoyama M; Dockter J; Oldstone MB; Whitton JL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; Although primary antiviral CD8+ cytotoxic T lymphocytes (CTL) can be induced in mice depleted of CD4+ T cells, the role of CD4+ T lymphocytes in the generation and maintenance of antiviral memory CTL is uncertain. This question, and the consequences upon vaccine-mediated protection, were investigated in transgenic CD4
Substitution of a single amino acid residue is sufficient to allow the human amphotropic murine leukemia virus receptor to also function as a gibbon ape leukemia virus receptor.: J Virol. 1996 Feb;70(2):1080-5. Unique Identifier : AIDSLINE MED/96135221; Eiden MV; Farrell KB; Wilson CA; Laboratory of Cell Biology, National Institute of Mental Health,; Bethesda, Maryland 20892, USA.; We have previously reported the unique properties of a receptor for amphotropic murine leukemia viruses (A-MuLVs) expressed on Chinese hamster E36 cells (C.A. Wilson, K.B. Farrell, and M.V. Eiden, J. Virol. 68:7697-7703, 1994). This receptor, HaPiT2 (formerly designated EAR), in contrast to the human form of the A-MuL
Multidrug-resistant human immunodeficiency virus type 1 strains resulting from combination antiretroviral therapy.: J Virol. 1996 Feb;70(2):1086-90. Unique Identifier : AIDSLINE MED/96135222; Iversen AK; Shafer RW; Wehrly K; Winters MA; Mullins JI; Chesebro B; Merigan TC; Division of Infectious Diseases and Geographic Medicine, Stanford; University, California 94305, USA.; Multidrug-resistant human immunodeficiency virus type 1 (HIV-1) strains with reverse transcriptase (RT) mutations at codons A62-->V, V75-->I, F77-->L, F116-->Y, and Q151-->M have been reported in patients receiving combination therapy with zidovudine (
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.: J Virol. 1996 Feb;70(2):1100-8. Unique Identifier : AIDSLINE MED/96135224; Trkola A; Purtscher M; Muster T; Ballaun C; Buchacher A; Sullivan N; Srinivasan K; Sodroski J; Moore JP; Katinger H; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; We have isolated and characterized human monoclonal antibody 2G12 to the gp120 surface glycoprotein of human immunodeficiency virus type 1 (HIV-1). This antibody potently and broadly neutralizes primary and T-cell line-adapted clade B strains of HIV-1 in a peripheral blood mononuclear cell-based assay and inhibits syn
Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein.: J Virol. 1996 Feb;70(2):1282-7. Unique Identifier : AIDSLINE MED/96135251; Kubota S; Duan L; Furuta RA; Hatanaka M; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania, USA.; Rev, a major regulatory protein of human immunodeficiency virus type 1, has been demonstrated to shuttle between the nucleus and cytoplasm of infected cells. The fate of the Rev protein in living cells was evaluated by pulse-chase experiments using a transient Rev expression system. Sixteen hours after chasing with un
Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants.: J Virol. 1996 Feb;70(2):1301-9. Unique Identifier : AIDSLINE MED/96135255; Carrillo A; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110, USA.
Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.: J Virol. 1996 Feb;70(2):1310-6. Unique Identifier : AIDSLINE MED/96135256; Carrillo A; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110, USA.; Insertion of T-cell line-tropic V3 and V4 loops from the HXB2 strain into the macrophage-tropic YU-2 envelope resulted in a virus with delayed infectivity for HUT78 and Jurkat cells compared with HXB2. Sequence analysis of viral DNA derived from long-term cultures of Jurkat cells revealed a specific mutation that chan
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication.: J Virol. 1996 Feb;70(2):689-96. Unique Identifier : AIDSLINE MED/96135175; de Vreese K; Kofler-Mongold V; Leutgeb C; Weber V; Vermeire K; Schacht S; Anne J; de Clercq E; Datema R; Werner G; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Bicyclams are a novel class of antiviral compounds which act as potent and selective inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2. They block an early step in the viral life cycle following adsorption to the CD4 receptor and preceding reverse transcription. To identify the mol
Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme.: J Virol. 1996 Feb;70(2):697-704. Unique Identifier : AIDSLINE MED/96135176; Bouhamdan M; Benichou S; Rey F; Navarro JM; Agostini I; Spire B; Camonis J; Slupphaug G; Vigne R; Benarous R; Sire J; INSERM U372, 13276 Marseille, France.; The role of the accessory gene product Vpr during human immunodeficiency virus type 1 infection remains unclear. We have used the yeast two-hybrid system to identify cellular proteins that interact with Vpr and could be involved in its function. A cDNA clone which encodes the human uracil DNA glycosylase (UNG), a DNA
Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA.: J Virol. 1996 Feb;70(2):712-20. Unique Identifier : AIDSLINE MED/96135178; Arts EJ; Marois JP; Gu Z; Le Grice SF; Wainberg MA; McGill AIDS Centre, Lady Davis Institute, Jewish General; Hospital, Montreal, Quebec, Canada.; We have compared the effects of nucleoside analogs in quiescent and phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) exposed to human immunodeficiency virus type 1 (HIV-1) with those of their triphosphorylated derivatives in cell-free HIV-1 reverse transcription assays. We observed a subst
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection.: J Virol. 1996 Feb;70(2):721-8. Unique Identifier : AIDSLINE MED/96135179; Leavitt AD; Robles G; Alesandro N; Varmus HE; Department of Laboratory Medicine, University of California, San; Francisco 94143-0100, USA.; The viral integrase (IN) protein is the only viral protein known to be required for integration of the human immunodeficiency virus type 1 (HIV-1) genome into the host cell DNA, a step in the viral life cycle that is essential for viral replication. To better understand the relationship between in vitro IN activity an
Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein.: J Virol. 1996 Feb;70(2):753-62. Unique Identifier : AIDSLINE MED/96135183; Richardson TM Jr; Stryjewski BL; Broder CC; Hoxie JA; Mascola JR; Earl PL; Doms RW; Department of Pathology, University of Pennsylvania, Philadelphia; 19104, USA.; The humoral immune response to human immunodeficiency virus type 1 (HIV-1) is often studied by using monomeric or denatured envelope proteins (Env). However, native HIV-1 Env complexes that maintain quaternary structure elicit immune responses that are qualitatively distinct from those seen with monomeric or denatured
Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro.: J Virol. 1996 Feb;70(2):771-7. Unique Identifier : AIDSLINE MED/96135185; Schmalzbauer E; Strack B; Dannull J; Guehmann S; Moelling K; Institut fur Medizinische Virologie, Universitat Zurich,; Switzerland.; The nucleocapsid (NC) protein of human immunodeficiency virus type 1 is required for packaging of viral RNA and for virion assembly. It contains two clusters of basic amino acids, consisting of five and four amino acid residues, flanking the first of its two zinc fingers. These amino acid residues have been mutagenize
The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.: J Virol. 1996 Feb;70(2):809-19. Unique Identifier : AIDSLINE MED/96135190; Schubert U; Bour S; Ferrer-Montiel AV; Montal M; Maldarell F; Strebel K; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460,; USA.; The human immunodeficiency virus type 1 (HIV-1) Vpu protein is an integral membrane phosphoprotein that induces CD4 degradation in the endoplasmic reticulum and enhances virus release from the cell surface. CD4 degradation is specific, requires phosphorylation of Vpu, and involves the interaction between Vpu and the C
The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?: J Virol. 1996 Feb;70(2):820-9. Unique Identifier : AIDSLINE MED/96135191; Bour S; Schubert U; Peden K; Strebel K; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.; The Vpu protein is a human immunodeficiency virus type 1 (HIV-1)-specific accessory protein that is required for the efficient release of viral particles from infected cells. Even though HIV-2 does not encode Vpu, we found that this virus is nevertheless capable of efficiently releasing virus particles. In fact, the r
Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion.: J Virol. 1996 Feb;70(2):843-51. Unique Identifier : AIDSLINE MED/96135194; Utz U; Banks D; Jacobson S; Biddison WE; Institut de recherches cliniques de Montreal, Laboratoire; d'Immunologie, Montreal, Canada.; Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neurological disease characterized by marked degeneration of the spinal cord and the presence of antibodies against HTLV-1. Patients with HAM/TSP, but not asymptomatic carriers, show very
trans-acting proteins involved in RNA encapsidation and viral assembly in human immunodeficiency virus type 1.: J Virol. 1996 Feb;70(2):880-6. Unique Identifier : AIDSLINE MED/96135198; Kaye JF; Lever AM; Department of Medicine, Addenbrooke's Hospital, Cambridge, United; Kingdom.; The human immunodeficiency virus type 1 gag gene product Pr55gag self-assembles when expressed on its own in a variety of eukaryotic systems. Assembly in T lymphocytes has not previously been studied, nor is it clear whether Pr55gag particles can package genomic RNA or if the Gag-Pol polyprotein is required. We have u
An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer.: J Virol. 1996 Feb;70(2):887-97. Unique Identifier : AIDSLINE GENBANK/K01384; Purcell DF; Broscius CM; Vanin EF; Buckler CE; Nienhuis AW; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.; Direct RNA-PCR analyses of T-cell lymphomas that developed in rhesus macaques during a gene transfer experiment revealed the presence of several different recombinant murine leukemia viruses (MuLV). Most prominent was the expected MuLV recombinant, designated MoLTRAmphoenv in which the amphotropic env of the helper pa
Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea.: J Virol. 1996 Feb;70(2):898-904. Unique Identifier : AIDSLINE MED/96135200; Tumpey TM; Chen SH; Oakes JE; Lausch RN; Department of Microbiology and Immunology, College of Medicine,; University of South Alabama, Mobile 36688, USA.; Herpes simplex virus type 1 (HSV-1) infection of the murine cornea induces the rapid infiltration of neutrophils. We investigated whether these cells could influence virus replication. BALB/c mice treated with monoclonal antibody (MAb) RB6-8C5 experienced a profound depletion of neutrophils in the bloodstream, spleen,
PCR-in situ hybridization detection of human T-cell lymphotropic virus type 1 (HTLV-1) tax proviral DNA in peripheral blood lymphocytes of patients with HTLV-1-associated neurologic disease.: J Virol. 1996 Feb;70(2):924-33. Unique Identifier : AIDSLINE MED/96135203; Levin MC; Fox RJ; Lehky T; Walter M; Fox CH; Flerlage N; Bamford R; Jacobson S; Neuroimmunology Branch, National Institute of Neurological; Diseases and Stroke, NIH, Bethesda, MD 20852, USA.; PCR-in situ hybridization (PCR-ISH) was developed and utilized to determine the distribution of human T-cell lymphotropic virus type 1 (HTLV-1) tax proviral DNA in peripheral blood lymphocytes (PBL) from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). PCR-ISH of HTLV-1 tax DNA in PBL
The human immunodeficiency virus type 1 5' packaging signal structure affects translation but does not function as an internal ribosome entry site structure.: J Virol. 1996 Feb;70(2):944-51. Unique Identifier : AIDSLINE MED/96135205; Miele G; Mouland A; Harrison GP; Cohen E; Lever AM; University of Cambridge Department of Medicine, Addenbrooke's; Hospital, United Kingdom.; The role of the RNA secondary structure in the 5 packaging signal region of human immunodeficiency virus type 1 (HIV-1) in initiating translation of gag mRNA has been investigated both in vitro and in the presence of cellular cofactors in vivo. Heat denaturation of the structure and mutagenic deletion both lead to an
Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).: J Virol. 1996 Feb;70(2):966-75. Unique Identifier : AIDSLINE MED/96135208; Wakefield JK; Kang SM; Morrow CD; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; The initiation of human immunodeficiency virus type 1 reverse transcription occurs by extension of a tRNA(Lys3) primer bound near the 5 end of the viral RNA genome which is designated the primer binding site (PBS). Sequences within the viral genome upstream of the PBS which are complementary to the anticodon loop (US
Physician satisfaction with human immunodeficiency virus type 1 and hepatitis B virus testing in San Diego County.: Med Care. 1996 Jan;34(1):1-10. Unique Identifier : AIDSLINE MED/96142306; Rau J; Cross JL; Hofherr LK; Peddecord KM; Benenson AS; Garfein RS; Francis DP; Laboratory Assurance Program, Graduate School of Public Health,; College of Health and Human Services, San Diego State University,; CA 92182-4162, USA.; Physician satisfaction with the laboratory testing process is one indicator of the physician s perception of the quality of laboratory testing and the effectiveness of the communication of the laboratory results. This study compares the level of satisfaction of physicians reporting their experience with human immunode
Health values of patients infected with human immunodeficiency virus. Relationship to mental health and physical functioning.: Med Care. 1996 Jan;34(1):44-57. Unique Identifier : AIDSLINE MED/96142309; Tsevat J; Solzan JG; Kuntz KM; Ragland J; Currier JS; Sell RL; Weinstein MC; Department of Medicine, Beth Israel Hospital, Harvard Medical; School, Boston, MA, USA.; To assess the health values of patients infected with human immunodeficiency virus (HIV) and examine the relationships between their health values and health status at two points in time, the authors sought to determine whether patients physical and mental health statuses were good predictors of how they valued their
Natural history of untreated cytomegalovirus retinitis.: Lancet. 1995 Dec 23-30;346(8991-8892):1671-3. Unique Identifier : AIDSLINE MED/96110604; Bowen EF; Wilson P; Atkins M; Madge S; Griffiths PD; Johnson MA; Emery VC; Department of Virology, Royal Free Hospital School of Medicine,; Hampstead, London, UK.; Cytomegalovirus infection is common in patients with AIDS, and often causes retinitis. Treatment is rarely curative, but the progression of retinitis is delayed. The untreated course of cytomegalovirus retinitis in AIDS is unknown. We report a 35-year-old man with retinitis who ref
Detection of virus in vertically exposed HIV-antibody-negative children.: Lancet. 1996 Jan 27;347(8996):213-5. Unique Identifier : AIDSLINE MED/96148717; Newell ML; Dunn D; De Maria A; Ferrazin A; De Rossi A; Giaquinto C; Levy J; Alimenti A; Ehrnst A; Bohlin AB; Ljung R; Peckham C; Institute of Child Health, London, UK.; BACKGROUND: HIV-infected mothers can transmit their infection to their children in utero or at delivery (vertical transmission). There have been cases of children who were reported as acquiring infection vertically and later clearing the infection. We report the frequency of this phenomenon in a European cohort study.
Dementia in a 58-year-old woman.: Lancet. 1996 Jan 27;347(8996):236. Unique Identifier : AIDSLINE MED/96148724; Sellal F; Mohr M; Collard M; Institut d'Anatomie Pathologique, Hopitaux Universitaires de; Strasbourg, France.
HIV co-infection with a currently non-pathogenic flagellate [letter]: Lancet. 1996 Jan 27;347(8996):264-5. Unique Identifier : AIDSLINE MED/96148751; Jimenez MI; Lopez-Velez R; Molina R; Canavate C; Alvar J
Characterization of T cell clones from chagasic patients: predominance of CD8 surface phenotype in clones from patients with pathology.: Mem Inst Oswaldo Cruz. 1995 Jul-Aug;90(4):503-6. Unique Identifier : AIDSLINE MED/96092422; Cuna WR; Cuna CR; Departamento de Parasitologia, Instituto Boliviano de Biologia; de Altura, Facultad de Medicina, La Paz, Bolivia.; Human Chagas disease, caused by the protozoan Trypanosoma cruzi, is associated with pathological processes whose mechanisms are not known. To address this question, T cell lines were developed from chronic chagasic patients peripheral blood mononuclear cells (PBMC) and cloned. These T cell clones (TCC) were analyzed
The evolution of the Michigan AIDS Fund.: Mich Med. 1995 Dec;94(12):20-2. Unique Identifier : AIDSLINE MED/96137570; Strumwasser I
HIV/AIDS and nutrition in the 1990s [editorial; comment]: Nutr Clin Pract. 1995 Oct;10(5):165. Unique Identifier : AIDSLINE MED/96153310; Guenter P
A review of mechanisms of wasting in HIV disease [see comments]: Nutr Clin Pract. 1995 Oct;10(5):167-76. Unique Identifier : AIDSLINE MED/96153311; Fields-Gardner C; According to estimates, between 50% to 90% of patients infected with the Human Immunodeficiency Virus (HIV) will experience some form of malnutrition. The degree and types of malnutrition are attributed to alterations in nutrient intake, absorption, and metabolism. Causes for each of these changes are complex and mult
[Functional activity of T-, B-lymphocytes, and macrophages during suppression of expression of the env gene from an endogenous retrovirus genome]: Mol Biol (Mosk). 1995 May-Jun;29(3):612-8. Unique Identifier : AIDSLINE MED/96163170; Gaidul' KV; Chernukhin IV; Khaldoianidi SK; Svinarchuk FP; Vlasov VV; Kozlov VA; Incubation of murine spleen cells with antisense oligonucleotide complementary to initiation site of this gene highly increased RNA synthesis relative to the normal T- and B-lymphocytes from spleen. In macrophages, inhibition of gene env expression stimulated phagocytosis and IL-1 production. Under these conditions, t
Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.: N Engl J Med. 1996 Feb 15;334(7):426-31. Unique Identifier : AIDSLINE MED/96150231; O'Brien WA; Hartigan PM; Martin D; Esinhart J; Hill A; Benoit S; Rubin M; Simberkoff MS; Hamilton JD; Department of Medicine, West Los Angeles Veterans Affairs Medical; Center, CA 90073, USA.; BACKGROUND. Clinical trials of antiretroviral drugs can take years to complete because the outcomes measured are progression to the acquired immunodeficiency syndrome (AIDS) or death. Trials could be accelerated by the use of end points such as changes in CD4+ lymphocyte counts and plasma levels of human immunodeficie
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.: Nature. 1996 Jan 25;379(6563):349-53. Unique Identifier : AIDSLINE GENBANK/M96581; Liston P; Roy N; Tamai K; Lefebvre C; Baird S; Cherton-Horvat G; Farahani R; McLean M; Ikeda JE; MacKenzie A; Korneluk RG; Molecular Genetics Research Laboratory, Children's Hospital of; Eastern Ontario, Ottawa, Canada.; Dysregulation of apoptosis can result in inappropriate suppression of cell death, as occurs in the development of some cancers, or in failure to control the extent of cell death, as is believed to occur in acquired immunodeficiency and certain neurodegenerative disorders, such as spinal muscular atrophy (SMA). Recentl
Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus.: Neurosci Lett. 1995 Sep 15;197(3):215-8. Unique Identifier : AIDSLINE MED/96117198; Strijbos PJ; Zamani MR; Rothwell NJ; Arbuthnott G; Harkiss G; Department of Molecular Pharmacology, Wellcome Research; Laboratories, Beckenham, Kent, UK.; Infection by lentiviruses such as human immunodeficiency virus (HIV) and Maedi-Visna virus (MVV) is associated with neurodegenerative disorders. We have investigated the neurotoxic mechanisms of a synthetic peptide of transactivating protein tat of MVV in striatal neuronal cultures. Tat peptide (but not control peptid
Actionstat. Methemoglobinemia.: Nursing. 1995 Dec;25(12):25. Unique Identifier : AIDSLINE MED/96153203; Mathews LM; Mathews PJ
Interaction of ETS-1 and ERGB/FLI-1 proteins with DNA is modulated by spacing between multiple binding sites as well as phosphorylation.: Oncogene. 1996 Jan 4;12(1):11-8. Unique Identifier : AIDSLINE MED/96140822; Hodge DR; Robinson L; Watson D; Lautenberger J; Zhang XK; Venanzoni M; Seth A; Laboratory of Molecular Oncology, National Cancer Institute,; Frederick, MD 21702-1201, USA.; ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain
Resolution of cryptosporidial infection in mice correlates with parasite-specific lymphocyte proliferation associated with both Th1 and Th2 cytokine secretion.: Parasite Immunol. 1995 Sep;17(9):459-64. Unique Identifier : AIDSLINE MED/96143612; Tilley M; McDonald V; Bancroft GJ; London School of Hygiene and Tropical Medicine, Department of; Clinical Sciences, UK.; This study was designed to investigate and characterize T-cell responses which lead to elimination of a primary infection of Cryptosporidium muris in BALB/c mice. The proliferative response of spleen cells to parasite antigen was measured by uptake of 3H-thymidine and, in parallel, supernatants were removed from cells
Adhesion of human neuroblasts to HIV-1 tat.: Pediatr Res. 1995 Nov;38(5):792-6. Unique Identifier : AIDSLINE MED/96124129; Cornaglia-Ferraris P; De Maria A; Cirillo C; Cara A; Alessandri G; Department of Pediatric Hematology/Oncology, G. Gaslini; Children's Hospital, Genoa, Italy.; Several neuropathologic findings in infants and children with human immunodeficiency virus type-1 (HIV-1) infection are different from those observed in adults, probably related to the fact that the retroviral infection occurs in the setting of neuro-development. This report describes the interaction and biologic acti
Call for HIV therapy cash [interview]: Nurs Times. 1995 Nov 15-21;91(46):8. Unique Identifier : AIDSLINE MED/96138833; Ward P
How nurses cope with exposure to HIV infections [news]: Nurs Times. 1995 Dec 6-12;91(49):11-2. Unique Identifier : AIDSLINE MED/96153275; Reutter LI; Northcott HC
Plagued by prejudice [news]: Nurs Times. 1995 Dec 6-12;91(49):18. Unique Identifier : AIDSLINE MED/96153278; Payne D
Warning on infection risk to patients with HIV [news]: Nurs Times. 1995 Dec 6-12;91(49):8. Unique Identifier : AIDSLINE MED/96153274
Massive reversible pulmonary cysts in a patient with AIDS.: Postgrad Med J. 1995 Dec;71(842):753-4. Unique Identifier : AIDSLINE MED/96142752; Collazos J; Martinez E; Mayo J; Miguelez JL; Section of Infectious Diseases, Hospital de Galdakao, Vizcaya,; Spain.; We report the case of a patient with AIDS who presented with bilateral, massive pulmonary cystic disease and pneumothorax presumably caused by Pneumocystis carinii which responded to treatment with cotrimoxazole. Follow-up with sequential chest X-rays and computed tomography scans showed a progressive improvement in t
Chronic diarrhoea associated with Septata intestinalis [letter]: Postgrad Med J. 1995 Dec;71(842):764. Unique Identifier : AIDSLINE MED/96142757; Clark S; Morgan S; Williams J
An unclassified cerebral small cell tumor in a patient with human T-cell lymphotropic virus type 1-induced primary extranodal lymphoma.: Mod Pathol. 1995 Oct;8(8):811-6. Unique Identifier : AIDSLINE MED/96117029; Komori T; Kasajima T; Yamamoto T; Shibata N; Kobayashi M; Department of Pathology, Tokyo Women's Medical College, Japan.; We describe an autopsy case of a thalamic tumor in a patient with human T-cell lymphotropic virus type 1 (HTLV-1)-induced extranodal lymphoma of the skull. Neither brain tumors associated with adult T-cell leukemia nor HTLV-1-induced extranodal lymphoma of bone have previously been reported. The tumor, which resembled
Simultaneous development of two different B-cell lymphomas in a patient with acquired immune deficiency syndrome evidenced by molecular analysis.: Mod Pathol. 1995 Oct;8(8):825-9. Unique Identifier : AIDSLINE MED/96117031; Dubus P; MacGrogan G; Vital C; Martin-Negrier ML; Morlat P; Ragnaud JM; de Mascarel A; Bloch B; Merlio JP; Department of Pathology, Centre Hospitalo-Universitaire de; Bordeaux, Universite de Bordeaux II, France.; We report a case of a man positive for the human immunodeficiency virus who rapidly died of lymphoma with cerebral, lung, and pericardic involvement. After autopsy, histopathological study of the different tumor sites showed the same morphological feature of immunoblastic lymphoma, with large areas of necrosis. In sit
Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):111-5. Unique Identifier : AIDSLINE MED/96133887; Piller SC; Ewart GD; Premkumar A; Cox GB; Gage PW; John Curtin School of Medical Research, Australian National; University, Canberra, Australia.; A small (96-aa) protein, virus protein R (Vpr), of human immunodeficiency virus type 1 contains one hydrophobic segment that could form a membrane-spanning helix. Recombinant Vpr, expressed in Escherichia coli and purified by affinity chromatography, formed ion channels in planar lipid bilayers when it was added to th
Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):265-8. Unique Identifier : AIDSLINE MED/96133918; Gartenhaus RB; Wang P; Hoffmann P; Department of Medicine, Long Island Jewish Medical Center, Albert; Einstein College of Medicine, New Hyde Park, NY 11040, USA.; The WAF1/CIP1 protein has been identified as a downstream mediator of the tumor suppressor p53 in regulating cell cycle progression through a G1-phase check-point. Recent work has implicated the functional status of p53 as a critical determinant in the apoptotic response of certain cell lines to DNA damaging agents. B
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):34-8. Unique Identifier : AIDSLINE MED/96133872; Kleim JP; Rosner M; Winkler I; Paessens A; Kirsch R; Hsiou Y; Arnold E; Riess G; Hoechst AG, Frankfurt, Germany.; The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutations affecting the NNRTI-binding pocket, and five of six strains disp
Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):367-71. Unique Identifier : AIDSLINE MED/96133938; Bukrinskaya AG; Ghorpade A; Heinzinger NK; Smithgall TE; Lewis RE; Stevenson M; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68198-5120, USA.; In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infec
Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):383-7. Unique Identifier : AIDSLINE MED/96133941; Thornton AM; Buller RM; DeVico AL; Wang IM; Ozato K; Laboratory of Molecular Growth Regulation, National Institute of; Child Health and Human Development, National Institutes of; Health, Bethesda, MD 20892, USA.; ICSBP is a member of the interferon (IFN) regulatory factor (IRF) family that regulates expression of type I interferon (IFN) and IFN-regulated genes. To study the role of the IRF family in viral infection, a cDNA for the DNA-binding domain (DBD) of ICSBP was stably transfected into U937 human monocytic cells. Clones
Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):514-8. Unique Identifier : AIDSLINE MED/96133967; Barker RH Jr; Metelev V; Rapaport E; Zamecnik P; Hybridon, Inc., Worcester, MA 01605, USA.; We studied inhibition of growth of the malaria parasite Plasmodium falciparum in in vitro culture using antisense (AS) oligodeoxynucleotides (ODNs) against different target genes. W2 and W2mef strains of drug-resistant parasites were exposed to AS ODNs over 48 hr, and growth was determined by microscopic examination a
A mean field model of ligand-protein interactions: implications for the structural assessment of human immunodeficiency virus type 1 protease complexes and receptor-specific binding.: Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):60-4. Unique Identifier : AIDSLINE MED/96133877; Verkhivker GM; Rejto PA; Agouron Pharmaceuticals Inc., San Diego, CA 92121, USA.; We propose a general mean field model of ligand-protein interactions to determine the thermodynamic equilibrium of a system at finite temperature. The method is employed in structural assessments of two human immuno-deficiency virus type 1 protease complexes where the gross effects of protein flexibility are incorpora
Strategies of research for a vaccine against AIDS.: Pubbl Stn Zool Napoli II. 1995;17(1):141-9. Unique Identifier : AIDSLINE MED/96137666; Essex M; Harvard AIDS Institute, Boston, MA 02115, USA.; Retroviruses replicate by inserting their proviral DNA into host cell chromosomes, usually in cells of the immune system. Nevertheless, an efficacious and safe subunit recombinant vaccine has been prepared against the feline leukemia retrovirus of cats. Because of high rates of morbidity and mortality, particularly in
[Clinical experimentation with HIV vaccines: scientific and ethical dilemmas]: Pubbl Stn Zool Napoli II. 1995;17(1):151-69. Unique Identifier : AIDSLINE MED/96137667; Lallemant M; Le Coeur S; Harvard School of Public Health, Cancer Biology Department,; Boston, MA 02115, USA.; Developing a vaccine against HIV is one of the greatest challenges the scientific community faces today. Several vaccine candidates have undergone preliminary safety and immunogenicity studies in humans. Research teams are ready to test these vaccines in the field, yet the scientific community is divided as to whether
[Historical development of vaccines. Introduction: Hazards and rationality in the vaccinal approach]: Pubbl Stn Zool Napoli II. 1995;17(1):5-29. Unique Identifier : AIDSLINE MED/96137659; Moulin AM; CNRS-INSERM U. 158, Hopital Necker, Paris, France.; The aim of this paper is to introduce the one hundred years of vaccination that has passed since Louis Pasteur first coined this generic term. According to the late Jonas Salk, vaccinology is a science encompassing all aspects of vaccine from its conception in the laboratory to its production by companies and its appl
Re: Cole and Slocumb's response to AIDS, nurses' intentions, and the interpretation of findings [letter]: Res Nurs Health. 1996 Feb;19(1):83-4. Unique Identifier : AIDSLINE MED/96148937; Bennett JA
[Echographic and magnetic resonance aspects in a case of bacterial myositis in AIDS]: Radiol Med (Torino). 1995 Oct;90(4):489-91. Unique Identifier : AIDSLINE MED/96139099; Midiri M; Iovane A; Barbiera F; Istituto di Radiologia P. Cignolini, Policlinico P. Giaccone,; Palermo.
Exact logistic regression: theory and examples.: Stat Med. 1995 Oct 15;14(19):2143-60. Unique Identifier : AIDSLINE MED/96118091; Mehta CR; Patel NR; Department of Biostatistics, Harvard School of Public Health,; USA.; We provide an alternative to the maximum likelihood method for making inferences about the parameters of the logistic regression model. The method is based appropriate permutational distributions of sufficient statistics. It is useful for analysing small or unbalanced binary data with covariates. It also applies to sm
Specific interferon-gamma producing CD4+ and CD8+ T cells after autologous EBV-B stimulation: the necessity of restimulation.: Scand J Immunol. 1995 Dec;42(6):591-7. Unique Identifier : AIDSLINE MED/96150308; Vooijs WC; Nootebos MG; Wernert H; de Gast GC; Department of Immunohaematology, University Hospital Utrecht, The; Netherlands.; The response of T cells to produce interferon-gamma, to proliferate and to become cytotoxic after specific stimulation with low dose (2%) autologous EBV-B cells was investigated in 15 EBV seropositive and five seronegative patients. A significantly higher number of interferon-gamma producing cells (56 +/- 24 per 10(5)
Differential patterns of T-cell receptor BV-specific activation of T cells by gp120 from different HIV strains.: Scand J Immunol. 1995 Dec;42(6):598-606. Unique Identifier : AIDSLINE MED/96150309; Akolkar PN; Gulwani-Akolkar B; Silver J; Department of Medicine, North Shore University Hospital/Cornell; University Medical College, Manhasset, New York, USA.; Studies by several groups have suggested that HIV infection in vivo results in a BV-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. Our earlier studies demonstrated that both a crude extract of HIV451 as well as purified gp 160 from HIV451 could specifically activ
Preferential positive selection of T lymphocytes which express two different TCR alpha chains, an endogenous and a transgenic.: Scand J Immunol. 1995 Dec;42(6):651-61. Unique Identifier : AIDSLINE MED/96150315; Munthe LA; Sollien A; Dembic Z; Bogen B; Institute of Immunology and Rheumatology, University of Oslo,; Norway.; A hallmark of positive selection in T-cell receptor (TCR)-transgenic mice is a strong skewing towards the CD4+ or the CD8+ subset, depending on the class II or I restriction of the TCR, respectively. However, previous experiments in TCR transgenic mice specific for an Ig light chain (lambda 2(315)/I-Ed class II molecu
Tenidap, but not nonsteroidal anti-inflammatory drugs, inhibits T-cell proliferation and cytokine induction.: Scand J Immunol. 1995 Dec;42(6):686-93. Unique Identifier : AIDSLINE MED/96150319; Dolhain RJ; de Kuiper P; Verweij CL; Penders JM; Breedveld FC; Dijkmans BA; Miltenburg AM; Department of Rheumatology, University Hospital Leiden, The; Netherlands.; T-lymphocytes are involved in the inflammatory response that occurs in affected joints of patients with rheumatoid arthritis (RA). Some second-line disease modifying anti-rheumatic drugs used in the treatment of patients with RA are known to block T-cell activation. The present study assessed whether tenidap, an inves
[Clinical manifestations and course of cytomegalovirus colitis in AIDS patients]: Schweiz Med Wochenschr. 1995 Dec 16;125(50):2417-22. Unique Identifier : AIDSLINE MED/96135388; Giezendanner S; Wirth HP; Zala G; Weber R; Flury R; Meyenberger C; Abteilung fur Gastroenterologie, Universitatsspital Zurich.; The clinical findings and course in 10 HIV-positive patients with cytomegalovirus ( CMV ) colitis were analyzed. Homosexuality was the main risk factor for HIV infection. All patients had markedly reduced CD4 counts (mean 25 x
[HIV infection and AIDS in dentistry. A report on the scientific meeting of 29 September 1995: continuing education at the Institut de Medecine Dentaire in Geneva]: Schweiz Monatsschr Zahnmed. 1995;105(12):1602-3. Unique Identifier : AIDSLINE MED/96135625; Perrier M
NIH budget trouble for AIDS office? [news]: Science. 1996 Jan 19;271(5247):281. Unique Identifier : AIDSLINE MED/96144671
Toward an understanding of the correlates of protective immunity to HIV infection.: Science. 1996 Jan 19;271(5247):324-8. Unique Identifier : AIDSLINE MED/96144680; Haynes BF; Pantaleo G; Fauci AS; Department of Medicine, Duke Medical Center, Durham, NC 27710,; USA.; Considerable progress has been made recently in understanding the genetic, immunologic and virologic factors in human immunodeficiency virus (HIV)-infected individuals who either rapidly progress or do not progress to acquired immunodeficiency syndrome (AIDS). In addition, detection of HIV-specific immune responses in
HIV/AIDS testing remains prickly affair [news]: S Afr Med J. 1995 Aug;85(8):725-6. Unique Identifier : AIDSLINE MED/96166272; van der Linde I
Antibodies to HCV and HTLV-I in a group of HIV-seropositive STD patients [letter]: S Afr Med J. 1995 Aug;85(8):792. Unique Identifier : AIDSLINE MED/96166297; van der Ryst E; Pretorius A; Smith MS
[Relationship between Epstein-Barr virus and lymphoproliferative syndromes in patients without immunodeficiency]: Sangre (Barc). 1995 Oct;40(5):383-7. Unique Identifier : AIDSLINE MED/96151807; Barranco M; Vidal J; Quintero L; Vives-Corrons JL; Jimenez de Anta MT; Servicio de Microbiologia Hospital Clinico y Provincial,; Faeultad de Medicina, Universidad de Barcelona.; PURPOSE: The relationship between Epstein-Barr virus (EBV) and infectious mononucleosis, pharyngeal carcinoma and Burkitt s lymphoma is well known. Further relationship seems to exist between EBV and the lymphoproliferative syndromes appearing in immunodeficient subjects. The present work is aimed to study the possibl
[The actual risk of retrovirus transmission from transfusions]: Sangre (Barc). 1995 Oct;40(5):407-16. Unique Identifier : AIDSLINE MED/96151811; Soriano V; Mas A; Servicio de Enfermedades Infecciosas, Instituto de Salud Carols; III., Madrid.
[Adult HTLV-I positive leukemia-lymphoma in Argentina]: Sangre (Barc). 1995 Oct;40(5):421-4. Unique Identifier : AIDSLINE MED/96151813; Gioseffi ON; Nucifora E; Fantl D; Dufour C; Milone J; Di Paolo H; Hospital Nacional Profesor Alejandro Posadas, Prov. de Buenos; Aires, Argentina.; Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukaemia/lymphoma (ATLL) and tropical spastic paraparesis (TSP/HAM) in endemic and non-endemic areas. Serological studies have shown that HTLV-I is prevalent in some Latin American countries such as Brasil,
Respite care for HIV-affected families.: Soc Work Health Care. 1995;21(1):55-67. Unique Identifier : AIDSLINE MED/96124326; Weiler JB; New York Hospital-Cornell Medical Center, New York, USA.; Anonymous testing of all newborn infants in 1988 revealed that one of every 61 babies born in New York City was HIV positive (New York City Department of Health, 1988). With the availability of new treatment, HIV positive children are living longer, often into their school years, and most are able to live at home. The
Afro-American women living with HIV infection: special therapeutic interventions for a growing population.: Soc Work Health Care. 1995;21(2):41-53. Unique Identifier : AIDSLINE MED/96124317; Williams JK; HIV Counseling Program, National Institutes of Health, Bethesda,; MD, USA.
Central nervous system tuberculosis: medical management and surgical indications.: Surg Neurol. 1995 Oct;44(4):378-84; discussion 384-5. Unique Identifier : AIDSLINE MED/96149527; Gropper MR; Schulder M; Sharan AD; Cho ES; Division of Neurosurgery, Northwestern Memorial Hospital,; Chicago, Illinois 60611, USA.; BACKGROUND: An increase in the incidence of tuberculosis in industrialized nations has prompted a need for earlier diagnosis, treatment, and isolation of disease. An associated rise in the number of patients with central nervous system tuberculosis (CNS TB) has forced neurosurgical services to reevaluate the indicatio
Interstitial pneumonitis in patients infected with the human immunodeficiency virus.: Thorax. 1995 Nov;50(11):1141-6. Unique Identifier : AIDSLINE MED/96149316; Griffiths MH; Miller RF; Semple SJ; Department of Histopathology, University College London Medical; School, London, UK.; BACKGROUND--A study was performed to identify the clinical, radiographic, and histopathological features of interstitial pneumonitis in patients infected with the human immunodeficiency virus. METHODS--A retrospective review was made of the case notes, chest radiographs, and histopathological results of seven HIV-1 an
Mycobacterial infection in HIV seropositive and seronegative populations, 1987-93.: Thorax. 1995 Nov;50(11):1147-50. Unique Identifier : AIDSLINE MED/96149317; Taylor IK; Evans DJ; Coker RJ; Mitchell DM; Shaw RJ; Department of Respiratory Medicine, St Mary's Hospital Medical; School, London, UK.; BACKGROUND--Although the causes of the worldwide resurgence of tuberculosis are multifactorial, the HIV epidemic is believed to have had a central role. Control is further threatened by the emergence of multidrug-resistant tuberculosis. METHODS--A retrospective evaluation was undertaken of trends in pulmonary and extr
HIV related bronchiectasis [letter]: Thorax. 1995 Nov;50(11):1227. Unique Identifier : AIDSLINE MED/96149335; Holmes AH; Pelton S; Steinbach S; Luzzi GA
Pulmonary complications of HIV disease: 10 year retrospective evaluation of yields from bronchoalveolar lavage, 1983-93.: Thorax. 1995 Dec;50(12):1240-5. Unique Identifier : AIDSLINE MED/96138474; Taylor IK; Coker RJ; Clarke J; Moss FM; Nieman R; Evans DJ; Veale D; Shaw RJ; Robinson DS; Mitchell DM; Department of Respiratory Medicine, St Mary's Hospital Medical; School, London, UK.; BACKGROUND--Pulmonary disease is a major contributor to morbidity and mortality in patients with HIV infection and AIDS. The aim of this study was to describe bronchoscopic findings and the spectrum of pulmonary pathogens in HIV seropositive patients undergoing investigation of respiratory disease over a 10 year perio
[Failing fight against AIDS (letter)]: Tidsskr Nor Laegeforen. 1996 Jan 10;116(1):111. Unique Identifier : AIDSLINE MED/96151872; Wessel I
[Combination therapy of HIV (letter)]: Ugeskr Laeger. 1996 Jan 8;158(2):175-6. Unique Identifier : AIDSLINE MED/96148323; Gerstoft J; Pedersen BK; Dansk Selskab for Infektions-medicin, Kobenhavn.
Interferon treatment inhibits virus replication in HIV-1- and SIV-infected CD4+ T-cell lines by distinct mechanisms: evidence for decreased stability and aberrant processing of HIV-1 proteins.: Virology. 1995 Dec 20;214(2):379-86. Unique Identifier : AIDSLINE MED/96130176; Agy MB; Acker RL; Sherbert CH; Katze MG; Regional Primate Research Center, School of Medicine, University; of Washington, Seattle 98185, USA.; We have examined the effects of interferon (IFN)-alpha/beta on HIV-1 and SIV replication in CD4+ T-cell lines. To enable us to examine these effects on a single cycle of virus replication, cells were synchronously infected with HIV-1 LAI or SIV mac251. Cell lines included MT4 cells which were responsive to IFN and, as
Effector functions of antibody and CD8+ cells in resolution of rotavirus infection and protection against reinfection in mice.: Virology. 1995 Dec 20;214(2):387-97. Unique Identifier : AIDSLINE MED/96130177; McNeal MM; Barone KS; Rae MN; Ward RL; Division of Clinical Virology, James N. Gamble Institute of; Medical Research, Cincinnati, Ohio 45219, USA.; The importance of antibody and CD8+ cells in resolution of murine rotavirus (EDIM) infection and protection against reinfection was examined with two strains of B-cell-deficient mice. Following inoculation of one strain (JHD), rotavirus infection was resolved within days, but when later reinoculated with EDIM, these m
Avian sarcoma leukemia virus protease linked to the adjacent Gag polyprotein is enzymatically active.: Virology. 1995 Dec 20;214(2):439-44. Unique Identifier : AIDSLINE MED/96130183; Arad G; Bar-Meir R; Almog N; Chorev M; Kotler M; Department of Molecular Genetics, Hebrew University, Hadassah; Medical School, Jerusalem, Israel.; The activity of avian sarcoma leukemia virus (ASLV) protease (PR) prior to its release from the precursor protein was determined by introducing mutations at the cleavage site between PR and the adjacent upstream nucleocapsid (NC) protein. Gag DNA fragments containing these mutations were cloned into expression vectors
Role of glucocorticoid receptor binding sites in the human immunodeficiency virus type 1 long terminal repeat in steroid-mediated suppression of HIV gene expression.: Virology. 1995 Dec 20;214(2):512-21. Unique Identifier : AIDSLINE MED/96130191; Mitra D; Sikder SK; Laurence J; Department of Medicine, Cornell University Medical College, New; York, New York 10021, USA.; Dexamethasone inhibited human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-directed gene expression in cells of T and B lymphoblastoid lineages, but not in monocytic cells. Suppression required an intact glucocorticoid receptor (GR), as it was amplified by transfection of lymphocytes with a plasmid
Feline leukemia virus variants in experimentally induced thymic lymphosarcomas.: Virology. 1995 Dec 20;214(2):584-92. Unique Identifier : AIDSLINE MED/96130198; Pandey R; Bechtel MK; Su Y; Ghosh AK; Hayes KA; Mathes LE; Roy-Burman P; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033, USA.; This study was initiated to evaluate the in vivo infectivity and pathogenicity of a group of recombinant feline leukemia viruses (rFeLVs) previously generated by in vitro forced recombination between a FeLV subgroup A virus (FeLV-A) and an endogenous FeLV (enFeLV) envelope (env) element (Sheets et al., 1992, Virology
In vivo processing of Pr160gag-pol from human immunodeficiency virus type 1 (HIV) in acutely infected, cultured human T-lymphocytes.: Virology. 1995 Dec 20;214(2):624-7. Unique Identifier : AIDSLINE MED/96130203; Lindhofer H; von der Helm K; Nitschko H; Max von Pettenkofer-Institute, University of Munich, Germany.; The processing of the HIV-1 Pr160gag-pol precursor polyprotein was analyzed in freshly HIV-1-infected MT-4 cultured cells. Single intermediates of the processing cascade were characterized by immunoblotting using distinct antisera. A potent inhibitor of the HIV protease (PR), Ro 31-8959, was employed to block cleavage
The carboxy-terminal domain is essential for stability and not for virion incorporation of HIV-1 Vpr into virus particles.: Virology. 1995 Dec 20;214(2):647-52. Unique Identifier : AIDSLINE MED/96130208; Mahalingam S; Patel M; Collman RG; Srinivasan A; Department of Microbiology and Immunology, Jefferson Cancer; Institute, Thomas Jefferson University, Philadelphia,; Pennsylvania 19107, USA.; Vpr is one of the auxiliary gene products encoded by HIV-1 genome. Vpr is a 14-kDa protein and exhibits several interesting characteristics including incorporation into virus particles, oligomerization, localization in the nucleus, and positive regulation of virus replication in primary cells. In an effort to define t
Human PKR transfected into murine cells stimulates expression of genes under control of the HIV1 or HTLV-I LTR.: Virology. 1995 Dec 20;214(2):653-9. Unique Identifier : AIDSLINE MED/96130209; Meurs EF; McMillan N; Williams BR; Hovanessian AG; Southern PJ; Department of Microbiology, University of Minnesota, Minneapolis; 55455-0312, USA.; We have analyzed the effect of transfection into murine NIH/3T3 cells of the human dsRNA-activated kinase PKR on the expression of the beta-galactosidase reporter gene, placed under control of the HIV1 or the HTLV-I LTR. beta-Galactosidase expression is stimulated when the reporter plasmids are cotransfected with wild
Rapid generation of antibodies against the HTLV-II external envelope protein by growth of mouse plasmacytomas in SCID mice.: Virology. 1995 Dec 20;214(2):680-4. Unique Identifier : AIDSLINE MED/96130214; Li QX; Camerini D; Kuritzkes DR; Chen IS; Department of Microbiology and Immunology, UCLA School of; Medicine 90095, USA.; Recombinant human T-cell leukemia virus type II (HTLV-II) envelope external glycoprotein, gp46-II, was expressed using a vaccinia virus vector. A recombinant gp46-II fused to an epitope of the influenza virus hemagglutinin, YPYDVPDYA, was purified by immunoaffinity chromatography. The purified glycoprotein was used to
Influence of ORF2 on host cell tropism of feline immunodeficiency virus.: Virology. 1996 Jan 1;215(1):10-6. Unique Identifier : AIDSLINE MED/96146738; Waters AK; De Parseval AP; Lerner DL; Neil JC; Thompson FJ; Elder JH; Department of Molecular Biology, Scripps Research Institute, La; Jolla, California 92037, USA.; Feline immunodeficiency virus (FIV) is a lentivirus associated with an immunodeficiency syndrome of the domestic cat. A short open reading frame (ORF2), of unknown function, is present in all FIV isolates. We have investigated the role of ORF2 in determining the cell tropism of two infectious molecular clones of FIV.
Transmission of HIV-1 from productively infected mature Langerhans cells to primary CD4+ T lymphocytes results in altered T cell responses with enhanced production of IFN-gamma and IL-10.: Virology. 1996 Jan 1;215(1):51-60. Unique Identifier : AIDSLINE MED/96146742; Ludewig B; Gelderblom HR; Becker Y; Schafer A; Pauli G; Robert Koch-Institut, Berlin, Germany.; Mature Langerhans cells (mLC), the ex vivo correlates of interdigitating dendritic cells (IDC), are susceptible to infection with HIV-1. As IDC are important activators of T helper (Th) cells in vivo, we examined the interaction of HIV-1-infected mLC with CD4+ T lymphocytes. HIV-1-infected mLC readily formed clusters
SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes.: Virology. 1996 Jan 1;215(1):97-100. Unique Identifier : AIDSLINE MED/96146746; Gummuluru S; Novembre FJ; Seshi B; Dewhurst S; Department of Microbiology and Immunology, University of; Rochester Medical Center, New York 14642, USA.; The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an acutely pathogenic lentivirus that causes severe gastrointestinal disease in macaque monkeys. The studies reported here examine the basis for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric analysis of cultured macaque lymphocytes
What physicians should know about Africanized honeybees.: West J Med. 1995 Dec;163(6):541-6. Unique Identifier : AIDSLINE MED/96137730; Sherman RA; Medical Service, Veterans Affairs Medical Center, Long Beach,; USA.; The Africanized honeybee, popularly known as the killer bee, is already well established in Texas and has recently entered California and Arizona. As the Africanized honeybee spreads in North America, the medical community must become aware of the problems associated with this insect and ensure that sting emergencies
Syphilis. A tale of twisted treponemes.: West J Med. 1995 Dec;163(6):552-9. Unique Identifier : AIDSLINE MED/96137732; Flores JL; Department of Medicine, Veterans Affairs (VA) Medical Center, San; Francisco, CA 94121, USA.; Despite the widespread availability of effective treatment, the incidence of primary and secondary syphilis in the United States is on the rise. In addition, syphilis is occurring in a substantial number of patients infected with the human immunodeficiency virus (HIV), thus adding to t
Modern syphilis--still a shadow on the land [editorial]: West J Med. 1995 Dec;163(6):587-8. Unique Identifier : AIDSLINE MED/96137747; Lukehart SA
Detection and isolation of bovine immunodeficiency-like virus (BIV) in dairy herds of Costa Rica.: Zentralbl Veterinarmed [B]. 1995 May;42(3):155-61. Unique Identifier : AIDSLINE MED/96164783; Hidalgo G; Flores M; Bonilla JA; Centro de Investigacion en Biologia Celular y Molecular; Universidad de Costa Rica, San Pedro.; Serological (Western blot) detection of bovine immunodeficiency-like virus (BIV) in Holstein dairy herds is reported in Costa Rica for the first time, as well as the isolation of the virus, from a seropositive bovine, by cocultivation of peripheral blood mononuclear cells (PBMC)
Rapidly developing neurological symptoms in a 40-year-old man with AIDS [clinical conference]: Acta Neurol Belg. 1995 Dec;95(4):239-43. Unique Identifier : AIDSLINE MED/96142833; Brohee P; Farber CM; Van Vooren JP; Clumeck N; Hildebrand J; Department of Neurology, Hopital Erasme, Belgium.
HIV transmission during invasive radiologic procedures: estimate based on computer modeling.: AJR Am J Roentgenol. 1996 Feb;166(2):263-7. Unique Identifier : AIDSLINE MED/96143090; Hansen ME; McIntire DD; Department of Radiology, University of Texas Southwestern Medical; Center, Dallas 75235-8896, USA.; OBJECTIVE: The primary purpose of this study was to estimate the risk of HIV transmission from physicians to patients during invasive radiologic procedures and to compare this estimate with those previously derived for surgical procedures so that policy on possible practice restrictions can be decided. The risk of HIV
Histoplasma prostatic abscess: rare cause in an immunocompromised patient [letter]: AJR Am J Roentgenol. 1996 Feb;166(2):471. Unique Identifier : AIDSLINE MED/96143145; Shah RD; Nardi PM; Han CC
Kaposi's sarcoma on a lymphedematous arm after mastectomy.: Am J Clin Oncol. 1996 Feb;19(1):87-90. Unique Identifier : AIDSLINE MED/96152512; Ron IG; Amir G; Marmur S; Chaitchik S; Inbar MJ; Department of Oncology, Tel-Aviv Sourasky Medical Center, Sackler; Faculty of Medicine, Tel-Aviv University, Israel.; Two patients with Kaposi s sarcoma developing in an area of lymphedematous arm postmastectomy are reported. The Kaposi s sarcoma occurred after latent periods of 26 and 7 years following radical and modified-radical mastectomy, respectively, in the edematous tissue of the ipsilateral arm. The cutaneous nodules were pu
Diagnosis of microsporidial keratitis by confocal microscopy and the chromatrope stain.: Am J Ophthalmol. 1996 Jan;121(1):89-91. Unique Identifier : AIDSLINE MED/96142051; Shah GK; Pfister D; Probst LE; Ferrieri P; Holland E; Department of Ophthalmology, University of Minnesota Hospital; 55455-0501, USA.; PURPOSE: To illustrate the value of confocal microscopy and chromatrope stain in the diagnosis of microsporidial keratitis. METHODS: In vivo confocal microscopy was performed on a man with the human immunodeficiency virus who had severe bilateral epithelial keratitis refractory to topical antibacterial medications. Th
Squamous cell carcinoma of the conjunctiva in a patient with the acquired immunodeficiency syndrome.: Am J Ophthalmol. 1996 Jan;121(1):94-6. Unique Identifier : AIDSLINE MED/96142054; Muccioli C; Belfort R Jr; Burnier M; Rao N; Department of Ophthalmology, Sao Paulo-Paulista School of; Medicine, Sao Paulo Hospital, Brazil.; PURPOSE: To alert ophthalmologists to the possibility of human immunodeficiency virus (HIV) infection in individuals with conjunctival squamous cell carcinoma. METHODS: We treated a 24-year-old patient with the acquired immunodeficiency syndrome who developed a limbal mass. The mass was excised and examined by routine
Prophylaxis for HIV-related infections: a work in progress [editorial; comment]: Ann Intern Med. 1996 Feb 1;124(3):342-4. Unique Identifier : AIDSLINE MED/96148646; Powderly WG
USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: a summary [see comments]: Ann Intern Med. 1996 Feb 1;124(3):349-68. Unique Identifier : AIDSLINE MED/96148648
Zidovudine in patients with HIV infection [letter]: Ann Intern Med. 1996 Feb 1;124(3):371-2; discussion 372-3. Unique Identifier : AIDSLINE MED/96148653; Bucher HC; Griffith L
Zidovudine in patients with HIV infection [letter]: Ann Intern Med. 1996 Feb 1;124(3):372; discussion 372-3. Unique Identifier : AIDSLINE MED/96148654; Costagliola D; Mary-Krause M
Empiric outpatient management of HIV-related pneumonia: economical or unwise? [editorial]: Ann Intern Med. 1996 Feb 15;124(4):451-3. Unique Identifier : AIDSLINE MED/96151951; Masur H; Shelhamer J
Lens hydration in transgenic mice containing HIV-1 protease linked to the lens alpha A-crystallin promoter.: Arch Biochem Biophys. 1995 Dec 20;324(2):223-7. Unique Identifier : AIDSLINE MED/96132649; Bettelheim FA; Zeng FF; Bia Y; Tumminia SJ; Russell P; Chemistry Department, Adelphi University, Garden City, New York; 11530, USA.; Two constructs of transgenic mice, TG61 and TG72, containing HIV-1 protease linked to lens alpha A-crystallin promoter develop cataract. The TG61 construct exhibits cataractogenesis in utero, while in the TG72 construct frank opacities appear 24 days (homozygotes) and 26 days (hemizygotes) after birth. Differential sc
[Vesicourethral dysfunction in the acquired immunodeficiency syndrome (AIDS)]: Arch Esp Urol. 1995 Nov;48(9):915-21. Unique Identifier : AIDSLINE MED/96120167; Begara Morillas FJ; Salinas Casado J; Silmi Moyano A; Espinosa Fernandez B; Fernandez Lucas C; Roca Arbones V; Resel Estevez L; Catedra y Servicio de Urologia, Unidad de SIDA, Hospital; Universitario San Carlos, Madrid, Espana.; OBJECTIVES: Ten patients with AIDS and voiding disorders were assessed to determine the most common type of lower urinary tract dysfunction and its possible usefulness in detecting neurological disease. METHODS: A complete urodynamic evaluation was performed. RESULTS: The most common symptom was urge incontinence and
Characterization of postcardiac transplant lymphomas. Histology, immunophenotyping, immunohistochemistry, and gene rearrangement.: Arch Pathol Lab Med. 1996 Jan;120(1):41-8. Unique Identifier : AIDSLINE MED/96136015; Kowal-Vern A; Swinnen L; Pyle J; Radvany R; Dizikes G; Michalov M; Molnar Z; Department of Pathology, Loyola University Medical Center,; Maywood, Ill 60153, USA.; OBJECTIVE--Between 2% and 9% of cardiac transplant recipients develop posttransplant lymphoproliferative disease, which includes lymphomas. These are usually aggressive Epstein-Barr virus-associated B-cell proliferations similar to those seen in other immunodeficiency states. A retrospective pathologic study of the tu
Effect of leukocyte concentration and inoculum volume on the laboratory identification of cytomegalovirus in peripheral blood by the centrifugation culture-antigen detection methodology.: Arch Pathol Lab Med. 1996 Jan;120(1):53-6. Unique Identifier : AIDSLINE MED/96136017; Lipson SM; Falk LH; Lee SH; Jane and Dayton Brown and Dayton T. Brown, Jr., Virology; Laboratory, Department of Medicine, North Shore University; Hospital-Cornell University Medical College, Manhasset, NY 11030,; USA.; OBJECTIVE--To investigate the rate of Cytomegalovirus ( CMV ) detection in peripheral blood by shell vial assay-indirect immunofluorescent assay technology using two leukocyte inocula concentrations and different inoculum volumes containing equivalent cell concent
Facile syntheses of C2-symmetrical HIV-1 protease inhibitors.: Arch Pharm (Weinheim). 1995 Oct;328(10):699-704. Unique Identifier : AIDSLINE MED/96095533; Konig S; Ugi I; Schramm HJ; Max-Planck-Institute of Biochemistry, Martinsried, Germany.; With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2-symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After bromination of 3a
Endosomolytic activity of cationic liposomes enhances the delivery of human immunodeficiency virus-1 trans-activator protein (TAT) to mammalian cells.: Biochem Biophys Res Commun. 1995 Dec 26;217(3):761-8. Unique Identifier : AIDSLINE MED/96125309; Huang L; Farhood H; Serbina N; Teepe AG; Barsoum J; Department of Pharmacology, University of Pittsburgh, School of; Medicine, PA 15261, USA.; We have explored the use of cationic liposomes to deliver the human immunodeficiency virus-1 trans-activator protein tat using a reporter gene expression assay. The human epidermoid carcinoma cell A431 stably transfected with a reporter gene under the control of human immunodeficiency virus-1 promoter was used as a ta
Characterization of the DNA-binding activity of HIV-1 integrase using a filter binding assay.: Biochem Biophys Res Commun. 1995 Dec 26;217(3):802-10. Unique Identifier : AIDSLINE MED/96125314; Haugan IR; Nilsen BM; Worland S; Olsen L; Helland DE; Laboratory of Biotechnology, University of Bergen, Norway.; Based on the selective binding of proteins and DNA to distinct filter materials a double-layered dot blot radio assay was developed to evaluate the binding of DNA to HIV-1 integrase. In this assay the DNA-binding was found to be independent of Mn2+ concentration, inhibited by concentrations of Mg2+ above 5 mM, abolish
AIDS/HIV clinical trials and treatment directory for New England.: Brookline, MA : Community Research Initiative of New England, [1995] 39 p Unique Identifier : AIDSLINE CAT/9516584
Clinical guide to AIDS and HIV.: Philadelphia : Lippincott-Raven, c1996 Unique Identifier : AIDSLINE CAT/9602060; Wormser GP
Cultural factors among Hispanics : perception and prevention of HIV infection.: New York : The Corporation, 1991 26 p. : ill Unique Identifier : AIDSLINE CAT/9601316
Human T-cell lymphotropic virus type I.: Chichester ; New York : J. Wiley and Sons, c1996 Unique Identifier : AIDSLINE CAT/9602385; Hollsberg P
HIV/AIDS, STDs, and skin diseases in Malawi : a review of literature.: [Zomba] : University of Malawi, Centre for Social Research, [1995] x, 96 leaves Unique Identifier : AIDSLINE CAT/9517261; Bisika TJ
In vitro and in vivo inhibition of tumorigenicity of neoplastic Kaposi's sarcoma cell line (KS Y-1) by liposomal IL-6, IL-8 and VEGF antisense oligodeoxynucleotides (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2461 1995. Unique Identifier : AIDSLINE ICDB/96610235; Thierry AR; Zeman RA; Hung JW; Bryant JL; Gallo RC; Lunardi-Iskandar Y; Laboratory of Tumor Cell Biology, NCI, NIH, Bethesda, MD 20892; High levels of IL-6, IL-8 and VEGF have been found in the serum of AIDS-KS patients and high amounts of these cytokines are produced by a recently established neoplastic KS cell line (KS Y-1). In this study, we proposed to use antisense oligo(dN) to inhibit KS cell production of these factors, and consequently study t
Substitution of HIV RT for E coli DNA polymerase I: An assay to screen for anti-HIV RT inhibitors in bacteria (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2463 1995. Unique Identifier : AIDSLINE ICDB/96610237; Kim B; Loeb LA; The Joseph Gottstein Memorial Cancer Research Laboratory,; Department of Pathology, SM-30, University of Washington,; Seattle, WA 98195; We present evidence that human immunodeficiency virus reverse transcriptase (HIV RT) can functionally complement two temperature sensitive phenotypes exhibited by the Escherichia coli (E coli) mutant, polA12recA718. Expression of HIV RT enables this E coli mutant to grow at a non-permissive temperature and, in additio
Reference databases of cytokine structure and function (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2801 1995. Unique Identifier : AIDSLINE ICDB/96610574; Casciari JJ; Fiege J; Sato H; Weinstein JN; Lab. of Molecular Pharmacology, DCT, NCI, Bethesda, MD 20892; In the last decade, the literature on cytokines has increased dramatically. In an attempt to sort out this information and present it in a user friendly form, we have developed reference databases of cytokine structure, receptors and function. To date, a total of 36 cytokines in 5 categories have been reviewed: interl
G(D2) oligosaccharide: Target for cytotoxic T-lymphocyte (CTL) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2846 1995. Unique Identifier : AIDSLINE ICDB/96610619; Zhao X; Cheung NV; Dept. of Pediatrics, Memorial Sloan Kettering Cancer Center, New; York, NY 10021; Carbohydrate antigens rarely provide target epitopes for CTL. Disialo-ganglioside G(D2) is expressed at high levels among human tumors (neuroblastomas, SCLC, melanomas, sarcomas, brain tumors) and a small group of murine lymphomas. Immunization of C57Bl/6 mice with irradiated EL4 cells stimulated a specific CTL respon
Characterization of autologous activated lymphocytes being used for adoptive immunotherapy of cancer (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2864 1995. Unique Identifier : AIDSLINE ICDB/96610637; Nayak SK; Beutel L; Irani S; Dillman RO; Hoag Cancer Center, Newport Beach, CA 92663; Our laboratory has been producing autologous activated lymphocytes (AAL) for use in a clinical trial of the National Biotherapy Study Group, using procedures similar to those previously reported (Osband et al, Lancet 335:994-8, 1990). Peripheral blood mononuclear cells from 19 different patients were stimulated in vit
A phase II study of the basic fibroblast growth factor (b-FGF) inhibiting agent pentosan polysulfate (PPS) in patients (pts) with AIDS-related Kaposi's sarcoma (AIDS-KS) (Meeting abstract).: Ann Oncol; 5(Suppl 8):3 1994. Unique Identifier : AIDSLINE ICDB/96612567; Sprinz E; Kalakun L; Prolla G; Machado VL; Sander E; Mans DR; Yamagushi M; Schwartsmann G; South-American Office for Anticancer Drug Development (SOAD),; Porto Alegre Hospital de Clinicas de Porto Alegre, Hospital de; Clinicas, Universidade de Sao Paulo, Brazil; B-FGF plays a key role in tumor growth and metastasis through paracrine stimulation of neoangiogenesis. The semi-synthetic heparinoid PPS prevents the binding of b-FGF to its receptor on endothelial cells, and may thus inhibit tumor growth by cutting off its blood supply. In this study, we evaluated PPS for its effica
The role of cytoplasmic proteolysis in apoptotic death triggered by cytotoxic lymphocytes and by the T cell receptor (Meeting abstract).: 10th International Symposium on Cellular Endocrinology: Molecular and Cell Biology of Apoptosis in Development, Disease and Cancer, September 29-October 2, 1994, Lake Placid, NY, p. 52, 1994.. Unique Identifier : AIDSLINE ICDB/96612824; Henkart P; Sarin A; Williams MS; Nakajima H; Experimental Immunology Branch, NCI, Bethesda, MD 20892; By transfecting noncytotoxic rat mast cell tumor cells with cDNAs coding for the lymphocyte granule components cytolysin (perforin) and the serine proteases granzyme A and granzyme B, we have created highly cytotoxic effectors which recognize IgE-coated targets. While granzyme expression has no effect with RBC targets
Interleukin 12 as immunoadjuvant (Meeting abstract).: J Immunother; 16(3):240 1994. Unique Identifier : AIDSLINE ICDB/96612839; Maguire HC Jr; Thomas Jefferson Univ., Philadelphia, PA; Interleukin-12 (IL-12), a heterodimeric molecule consisting of disulfide linked 35 kD and 40 kD chains, has pleiotropic effects including shifting the T helper cell response to a Th-1 cytokine profile. Since Th-1 cells are associated with the delayed type hypersensitivity response, we inquired in a mouse model whether
Induction of autonomous growth of HTLV-I infected human lymphocytes (Meeting abstract).: Proc Annu Meet Jpn Cancer Assoc; 6:140 1994. Unique Identifier : AIDSLINE ICDB/96612951; Maruyama K; Mochizuki S; Kawamura K; Koshikawa N; Pathol. Div., Chiba Cancer Center Research Inst., Japan; A cell line, Coculture-5, derived from normal human lymphocytes achieved lymphokine dependent continuous proliferation following in vitro infection with HTLV-I. Coculture-5 cells exhibited gene and chromosome rearrangements specific for the cell line and apparently related with the integration of HTLV-I proviral DNA.
HIV-associated lymphomas: an inverse correlation between p53 expression and Epstein-Barr virus infection (Meeting abstract).: J Pathol; 175(Suppl):113A 1995. Unique Identifier : AIDSLINE ICDB/96615155; Cordell-Smith J; Pringle JH; Henry K; Angus B; Krajewski A; Hell K; Lauder I; Department of Pathology, University of Leicester, Clinical; Sciences Building, Leicester Royal Infirmary, PO Box 65,; Leicester, LE2 7LX; Infection with the human immunodeficiency virus (HIV) predisposes to the development of B-cell non-Hodgkin s lymphoma (NHL). In a large proportion of such malignancies the Epstein-Barr virus (EBV) is detectable within tumor cells and consequently the virus has been implicated in NH
Monoclonal antibodies directed against the Epstein-Barr virus encoded nuclear antigen 1: immunohistochemical detection of EBNA-1, in EBV associated tumors (Meeting abstract).: J Pathol; 175(Suppl 8):151A 1994. Unique Identifier : AIDSLINE ICDB/96615243; Reynolds GM; Young LS; Grasser FA; Mueller-Lantzsch N; Oates J; Kremmer E; Klein K; Remberger K; Feiden W; Niedobitek G; Murray PG; Dept. of Pathology, Univ. of Birmingham, UK; The Epstein-Barr virus nuclear antigen 1 (EBNA-1) is a protein consistently expressed in all forms of latent EBV infection. EBNA-1 appears to be essential for viral DNA replication and the maintenance of viral episomes in the infected cell. However, lack of suitable monoclonal antibodies has prevented the demonstratio
The efficient introduction of exogenous genes into human and murine primary lymphocytes.: Diss Abstr Int [B]; 55(7):2525 1995. Unique Identifier : AIDSLINE ICDB/96615432; Kuo M; Rutgers, The State Univ. of NJ, New Brunswick.; The efficient introduction of exogenous genes into primary lymphocytes is potentially important both for somatic cell gene therapy and for studying lymphocyte biology. The first part of this dissertation describes the use of retroviral vectors to efficiently transfer exogenous genes into primary murine T and B cells a
The manipulation of t cell costimulation in antitumor immunotherapy.: Diss Abstr Int [B]; 55(7):2639 1995. Unique Identifier : AIDSLINE ICDB/96615438; Townsend SE; Univ. of California, Berkeley; A variety of tumors are potentially immunogenic but do not stimulate an effective antitumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7
Neoadjuvant chemo-/radiotherapy in locally advanced non-small cell lung cancer (Meeting abstract).: Eur Respir J; 7(Suppl 18): 392s 1994. Unique Identifier : AIDSLINE ICDB/96615786; von Eiff M; Wagner W; Rube T; Geiger A; Klinke V; Thomas M; van de Loo J; Univ. of Munster, Germany; Objective: This phase II trial was designed to evaluate the feasibility, toxicity and response rates for neoadjuvant chemotherapy and radiotherapy followed by surgical resection in newly diagnosed patients (pts) with surgically staged III NSCLC (N2/3). Materials and Methods: Neoadjuvant treatment consisted of two cycl
Phosphorylation of HTLV Tax by a cyclin-dependent kinase regulates transactivation of the proviral LTR: implications for T-cell growth control (Meeting abstract).: Blood; 84(10, Suppl 1):247a 1994. Unique Identifier : AIDSLINE ICDB/96615857; Shen P; Park DS; Martin TL; Murton IB; Wachsman W; Research Service, San Diego VAMC, Div. of Hematology-Oncology and; Cancer Center, UCSD School of Medicine, La Jolla, CA; Human T-cell leukemia virus type 1 (HTLV-1) is etiologic for adult T-cell leukemia/lymphoma (ATLL). Experimental evidence implicates Tax, a HTLV accessory gene product, as playing a role in transformation of T-cells and development of ATLL. Tax is required for efficient viral replication and regulates expression of se
A Phase I study of tecogalan, a novel angiogenesis inhibitor in the treatment of AIDS-related Kaposi's sarcoma and solid tumors (Meeting abstract).: Blood; 84(10, Suppl 1):248a 1994. Unique Identifier : AIDSLINE ICDB/96615859; Tulpule A; Snyder JC; Espina BM; Higashi L; Satomi M; Lombardy EE; Gill PS; Univ. of Southern California School of Medicine, Los Angeles, CA; The proliferation of blood vessels is an important requirement in the growth and metastasis of solid tumors and hematologic malignancies. The inhibition of tumor angiogenesis might therefore be a rational therapeutic approach for malignancies. Tecogalan is a sulfated polysaccharide isolated from Arthrobacter species A
Phase II study of paclitaxel (Taxol) for the treatment of HIV-associated Kaposi's sarcoma (KS) (Meeting abstract).: Blood; 84(10, Suppl 1):248a 1994. Unique Identifier : AIDSLINE ICDB/96615860; Saville MW; Lietzau J; Pluda M; Wilson W; Bailey J; Cohen R; Feigal E; Humphrey R; Broder S; and Yarchoan R; NCI, Bethesda, MD; KS is a frequent cause of severe morbidity and death in patients with human immunodeficiency virus (HIV) infection. Current therapies are often poorly tolerated, and new drugs are needed for this condition. It has been observed that inhibitors of microtubule assembly are active against KS, and this led us to consider
Adoptive immunotherapy with human Epstein-Barr virus (EBV) specific cytotoxic T lymphocytes (CTL) for the treatment of severe combined immunodeficiency (SCID) mice bearing human EBV-induced B-cell lymphoproliferative disorders (EBV-LPD) (Meeting abstract).: Blood; 84(10, Suppl 1):398a 1994. Unique Identifier : AIDSLINE ICDB/96615954; Lacerda JF; Dennig D; Lucas K; Collins N; Ladanyi M; Papadopoulos E; O'Reilly RJ; Memorial Sloan-Kettering Cancer Center, New York, NY; Our group has reported a series of 5 patients who developed EBV-LPD after T-cell depleted bone marrow transplantation who achieved durable remissions after infusions of peripheral blood mononuclear cells (PBMC) from their EBV-seropositive donors (N Engl J Med 330:1185, 1994). To dissect this therapeutic effect, we est
Zidovudine as an antineoplastic agent in the treatment of HIV related high-grade non-Hodgkin lymphoma (Meeting abstract).: Blood; 84(10, Suppl 1):519a 1994. Unique Identifier : AIDSLINE ICDB/96615981; Tosi P; Gherlinzoni F; Visani G; Mazza P; Zinzani PL; Coronado O; Chiodo F; Darnowski JW; Tura S; Inst. Hematol. 'Seragnoli', Bologna Univ., Italy; We have previously reported that zidovudine ( AZT ) can possess a significant antineoplastic activity when combined with drugs that disrupt de novo thymidylate synthesis, such as 5-fluorouracil and methotrexate (MTX). The aim of this study is to evalu
Evidence for direct HIV involvement in a broad spectrum of AIDS-associated lymphomas (Meeting abstract).: Blood; 84(10, Suppl 1):520a 1994. Unique Identifier : AIDSLINE ICDB/96615983; McGrath MS; Herndier BG; Shiramizu B; San Francisco General Hosp., Univ. of California, San Francisco,; CA; Clonal integration of the human immunodeficiency virus (HIV) was recently discovered in four non-B-cell tumors using inverse polymerase chain reaction (IPCR). These four cases showed evidence for viral integration within the fur gene, upstream to the c-fes/fps oncogene. This was the first report of possible direct inv
A deletion variant of the latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus (EBV) is associated with transformation of angioimmunoblastic lymphadenopathy (AILD) into B-immunoblastic lymphoma (B-IBL) (Meeting abstract).: Blood; 84(10, Suppl 1):521a 1994. Unique Identifier : AIDSLINE ICDB/96615990; Knecht H;