Increased human natural killer lymphocyte subpopulation in blood of HIV infected men (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Increased human natural killer lymphocyte subpopulation in blood of HIV infected men (Meeting abstract).

3rd International Conference of the Mediterranean Society of Tumor Marker Oncology (MESTMO), October 26-29, 1994, Athens, Greece, A87, 1994.. Unique Identifier : AIDSLINE ICDB/95615060
Green LK; Griffin J; Baylor College of Medicine, Veterans Affairs Medical Center, 2002; Holcombe Blvd., Houston, TX 77030

Abstract: The human natural killer (NK) cell is a cell of undefined lineage that is capable of lysing certain tumor cell lines and bears surface receptors for the FcR portion of IgG. The number of cells identified as NK cells has been reported to be normal, increased, decreased and decreased but with increased activity in HIV infected patients. Their significance is unknown and perhaps an increase in their number results in a beneficial effect. At the Houston Veterans Affairs Medical Center, over 1700 immunodeficiency flow cytometry panels are performed per year on over 500 patients with AIDS related complex (ARC) and AIDS. Over a three year period, we identified a small unique population of 33 HIV patients (ARC 3, AIDS 30) who had a decreased total T cell % (Anti-Leu-4/CD3, less than 60%) with an increase NK population (Anti-Leu-7 or HNK-1 and/or Anti-Leu-19). The AIDS patients all had CD4 counts (T-Helper cells) less than 350 c/mm3. A matched population of HIV infected patients (ARC 3, AIDS 30) with similar parameters but normal total T-cell % (greater than 68%) and NK subset were compared. The patients with decreased total T cells/increased NK cells did progressively worse clinically with a death rate of 21% as compared to the control patients with a death rate of 3%. In summary, an increase in NK cell subset did not result in a beneficial clinical outcome for the patient.

Keywords: CD4 Lymphocyte Count Flow Cytometry Human HIV Infections/*BLOOD/IMMUNOLOGY Killer Cells, Natural/*CYTOLOGY *Lymphocyte Subsets Male ABSTRACT
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