Characterization of cell lines derived from fibromatous tumors of a human immunodeficiency virus type 2-infected baboon (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Characterization of cell lines derived from fibromatous tumors of a human immunodeficiency virus type 2-infected baboon (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 36:A1208 1995. Unique Identifier : AIDSLINE ICDB/95608985
Blackbourn DJ; Herndier BG; Levy JA; University of California, San Francisco, CA 94143

Abstract: The objective of these studies was to determine the histogenesis of fibromatous tumors from human immunodeficiency virus type 2 (HIV-2)-infected baboons. Two baboons with no evidence of simian retrovirus (SRV) infection were experimentally infected with HIV-2. These animals developed an extensive fibromatosis condition characterized by vasocentric proliferation of fibroblast-like cells. Necropsy of one of these animals, 9429, revealed the abnormal hyperplasia to occur in the skin, visceral organs and lymph nodes. A tumor from this animal was analyzed by immunohistochemistry. Cell lines were derived from tumor biopsies taken from the skin of the second animal, 9206, and characterized by immunohistochemistry. The tumor from animal 9429 stained positively for smooth muscle actin and negatively for Factor VIII, S100 and keratin. Cell lines derived from tumor biopsies from animal 9206 stained positively for smooth muscle actin, desmin, vimentin and epithelial cell membrane antigen and negatively for Factor VIII, CD68 and S100. Virus particle associated reverse transcriptase activity could not be detected in the culture supernatants of these cell lines. HIV-2 infection of baboons can result in the development of fibrous tumors, the histogenesis of which appears to be a myofibroblast. A similar condition has been described in macaques with simian acquired immunodeficiency syndrome associated with SRV, where it has been considered analogous to Kaposi's sarcoma (KS) of humans. We are currently evaluating whether the tumors in the baboons are also related to KS.

Keywords: Animal Cell Division/PHYSIOLOGY *Cell Line Cell Transformation, Neoplastic/*PATHOLOGY Fibroma/*PATHOLOGY HIV Infections/*PATHOLOGY Papio Sarcoma, Kaposi's/PATHOLOGY Soft Tissue Neoplasms/*PATHOLOGY Tumor Cells, Cultured/*PATHOLOGY Tumor Markers, Biological/ANALYSIS ABSTRACT
950930
M9591326

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