Roxithromycin. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Roxithromycin. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Notes Undergr. 1995 Winter;(no 29):3-4. Unique Identifier : AIDSLINE AIDS/95700302

Abstract: The PWA Health Group now distributes roxithromycin (Ruclid) for cryptosporidiosis. Cryptosporidium parvum is a single-cell parasite that produces chronic watery diarrhea in people with compromised immune systems. Roxithromycin, a macrolide antibiotic, currently is used extensively in Europe and Latin America to treat a number of bacterial infections, including chlamydia, sinusitis, and skin and respiratory problems. At the 1994 International AIDS Conference, reports of two clinical studies showed that roxithromycin might effectively treat cryptosporidiosis. In both studies, patients took 300 mg of Roxy twice a day. In one study, complete clearance was seen in 5 patients, with improvement in 3 patients. Side effects of the drug seem to be minimal. One major concern is the possibility of elevated liver enzymes.

Keywords: AIDS-Related Opportunistic Infections/*DRUG THERAPY Clinical Trials Cryptosporidiosis/*DRUG THERAPY Feces/PARASITOLOGY Human Liver/ENZYMOLOGY Roxithromycin/ADVERSE EFFECTS/*THERAPEUTIC USE NEWSLETTER ARTICLE
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