Good results from eye implant study. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Good results from eye implant study. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Treat Review. 1995 Jan;(no 16):4. Unique Identifier : AIDSLINE AIDS/95700312

Abstract: Researchers are studying the use of ganciclovir, administered by eye implants, for the treatment of CMV retinitis. Participants in a 1992/1993 study who had received the implant showed no progression of the disease while a no-implant comparison group suffered a worsening infection. The implants are designed to gradually release the drug over several months; implant replacement time is unknown, but replacement after 32 weeks is advised. Following implantation, initial blurred vision occurred, but normal vision returned within a month. Another study revealed that the non-implanted eye of a CMV retinitis patient usually became infected, but when subsequently treated with the implant, took a positive course. A study comparing different treatments for CMV retinitis is enrolling. Participants will be treated either with standard IV ganciclovir, a ganciclovir implant with oral ganciclovir, or a ganciclovir implant with placebo. Participants must have CMV retinitis in one eye. Implants are available from the manufacturer through a compassionate use program. For more information, contact The Network at (800) 734-7104.

Keywords: Cytomegalovirus Retinitis/*DRUG THERAPY Double-Blind Method *Drug Implants Human Placebos NEWSLETTER ARTICLE RANDOMIZED CONTROLLED TRIAL CLINICAL TRIAL
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