1995

AIDs caregiving : universal precautions, protections, and psychosocial issues for home health aides. [videorecording]: [St. Louis, Mo.] : Mosby-Year Book, c1994 1 videocassette (25 min.) : sd., col. ; 1/2 in (Mosby's continuing health care education video series) Unique Identifier : AIDSLINE AV/9502116
[Virkelighed & visioner : HIV og AIDS : ideer til samordning af behandling, pleje og psykosocial stotte.]: [Copenhagen?] : Sundhedsstyrelsen, 1988 127 p. : ill Unique Identifier : AIDSLINE CAT/9500053
[Da pesquisa a acao : programa de DST/AIDS.]: Salvador-Bahia, Brasil : [s.n.], 1993 138 p Unique Identifier : AIDSLINE CAT/9506504
Thai sexual behavior and risk of HIV infection : a report of the 1990 survey of partner relations and risk of HIV infection in Thailand.: [S.l.] : Program on AIDS, Thai Red Cross Society, [1992] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9510581; Werasit Sittitrai
[AIDS : eine sexualisierte Krankheit und ihre Aspekte.]: Paderborn : Pabeba, c1992 195 p. : ill Unique Identifier : AIDSLINE CAT/9504037; Fesenfeld A
Human T-cell leukemia virus.: [Dallas, Tex.? : University of Texas Southwestern Medical Center, 1992] 38 p. : ill (Medical grand grounds) Unique Identifier : AIDSLINE CAT/9504163; Gaynor R
Primary school teachers knowledge and understanding of AIDS : report of a baseline study carried out in primary schools in Matabeleland South and Mashonaland East before the start of the National AIDS Programme for Schools.: Harare, Zimbabwe : Ministry of Education and Culture/UNICEF, [1993] 39 p. : ill Unique Identifier : AIDSLINE CAT/9510147
What grade 7 pupils know and think about AIDS : report of a baseline study carried out in primary schools in Matabeleland South and Mashonaland East before the start of the National AIDS Programme for Schools.: Harare, Zimbabwe : Ministry of Education and Culture/UNICEF, [1993] 40 p. : ill Unique Identifier : AIDSLINE CAT/9510148
Impact of the AIDS epidemic on health care services and planning in Europe.: Strasbourg : Council of Europe Press, 1993 48 p Unique Identifier : AIDSLINE CAT/9511338
Saskatchewan provincial HIV/AIDS strategy : phase 1.: [Regina?] Saskatchewan : Saskatchewan Health, [1993] 16 p. : ill Unique Identifier : AIDSLINE CAT/9511165
[A:construcao da solidariedade : AIDS, sexualidade, e politica no Brasil.]: Rio de Janeiro : ABIA, c1994 141 p (Historia social da AIDS ; no. 3) Unique Identifier : AIDSLINE CAT/9439446; Parker RG
[Du:sida : l'anticipation imaginaire de la mort et sa mise en discours.]: Paris : Denoel, c1994 267 p. : ill (L'espace analytique) Unique Identifier : AIDSLINE CAT/9423274; Saint-Jarre C
[Praticas sexuais e a infeccao pelo virus da imunodeficiencia humana.]: Goiania : AB Editora, 1994 xviii, 174 p. : ill Unique Identifier : AIDSLINE CAT/9506506; Gir E
Bleach availability and risk behaviours in prison in New South Wales.: Sydney : National Drug and Alcohol Research Centre, [1994] 27 p. : ill (Technical report ; no. 22) Unique Identifier : AIDSLINE CAT/9510506; Dolan KA
HIV transcription is induced with some forms of cell killing. [microform]: [Argonne, Ill.? : Argonne National Laboratory?, 1994?] 14 p. : ill Unique Identifier : AIDSLINE CAT/9511100; Woloschak GE
[Les:recherches soutenues : 1989/1993.]: Paris : Agence nationale de recherches sur le SIDA, [1994] 139 p Unique Identifier : AIDSLINE CAT/9507745
Candles of hope : the AIDS Programme of the Thai Red Cross Society. 1st ed.: London : ActionAid, 1994 43 p. : ill (Strategies for hope ; no. 9) Unique Identifier : AIDSLINE CAT/9510508; Werasit Sittitrai
National program on STD/AIDS = Programa nacional de DST/AIDS.: (Brazil) Brasil : Health Ministry, 1994 1 v. (unpaged) Unique Identifier : AIDSLINE CAT/9508234
AIDS prevention : hearing before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce, House of Representatives, One Hundred Third Congress, second session, July 12, 1994. [microform]: Commerce. Subcommittee on Health and the Environment Washington : U.S. G.P.O. : For sale by the U.S. G.P.O., Supt. of Docs., Congressional Sales Office, 1995 iii, 65 p Unique Identifier : AIDSLINE CAT/9510085
Counselling guidelines for HIV testing.: Ottawa : Canadian Medical Association, c1995 24 p Unique Identifier : AIDSLINE CAT/9510188
AIDS education through theatre : case studies from Uganda.: Bayreuth : E. Breitinger, c1995 183 p (Bayreuth African studies series, ISSN 0178-0034 ; 35) Unique Identifier : AIDSLINE CAT/9510796; Frank M
HIV and AIDS : a strategy for nursing care. 4th ed.: London : Arnold, 1995 xiii, 472 p. : ill Unique Identifier : AIDSLINE CAT/9510143; Pratt RJ; Pratt RJ
Preventing HIV transmission : the role of sterile needles and bleach.: Washington, D.C. : National Academy Press, 1995 xvii, 334 p. : ill Unique Identifier : AIDSLINE CAT/9511389; Normand J; Vlahov D; Moses LE; Bleach Distribution Programs
AIDS and beyond : dietary and lifestyle guidelines for new viral and bacterial diseases. 1st ed.: Beckett, Mass. : One Peaceful World Press, 1995 94 p Unique Identifier : AIDSLINE CAT/9510730; Kushi M
HIV & AIDS : the global inter-connection.: West Hartford, Conn. : Kumarian Press, 1995 xii, 227 p (Kumarian press books for a world that works) Unique Identifier : AIDSLINE CAT/9510727; Reid E
Increased human natural killer lymphocyte subpopulation in blood of HIV infected men (Meeting abstract).: 3rd International Conference of the Mediterranean Society of Tumor Marker Oncology (MESTMO), October 26-29, 1994, Athens, Greece, A87, 1994.. Unique Identifier : AIDSLINE ICDB/95615060; Green LK; Griffin J; Baylor College of Medicine, Veterans Affairs Medical Center, 2002; Holcombe Blvd., Houston, TX 77030; The human natural killer (NK) cell is a cell of undefined lineage that is capable of lysing certain tumor cell lines and bears surface receptors for the FcR portion of IgG. The number of cells identified as NK cells has been reported to be normal, increased, decreased and decreased but with increased activity in HIV i
Transgenic human O6-alkylguanine-DNA alkyltransferase decreases incidence and increases latency of MNU-induced thymic lymphomas in Ttg-1 transgenic mice (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1122 1995. Unique Identifier : AIDSLINE ICDB/95608899; Allay E; McGuire EA; Koc ON; Marko DA; Pincus E; Gerson SL; Cancer Research Center, Case Western Reserve Univ. Sch of Med,; Cleveland, OH 44106; Overexpression of alkyltransferase in thymus of MGMT transgenic mice prevents MNU-induced thymic lymphomas. Spontaneous lymphomas occur in transgenic mice expressing Ttg-1, the oncogene at [t(11:14)(p15:q11)] identified in 14% of patients with T-ALL. To better understand the role of DNA repair in chemical- and oncogen
Ectopic expression of proto-oncogene rhombotin-2 causes selective expansion of CD4-CD8- T-cell subset and thymic tumors in mice (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1125 1995. Unique Identifier : AIDSLINE ICDB/95608902; Goorha R; Neale G; Dept. of Virology and Molecular Biology, St. Jude Children's; Research Hosp., Memphis, TN 38101; The rhombotin-2 (RBTN-2) locus at chr 11p13 is the most frequent site of chromosomal translocation in childhood T-cell acute lymphoblastic leukemia. Although expressed widely, Rhom-2 is not expressed in T-lymphocytes. To investigate its mechanism of action in leukemogenesis, we constructed transgenic mice that express
Sequential neoplasia: a novel theory of pathogenesis for HIV-associated lymphoma and Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1181 1995. Unique Identifier : AIDSLINE ICDB/95608958; Herndier BG; Shiramizu BT; McGrath MS; Univ. of California San Francisco, San Francisco, CA 94143; In Cancer Research (Shiramizu et al, 54:2069-72, 1994) we presented 4 HIV-associated lymphoproliferations with nonrandom clonal integration of the retrovirus in the fur gene of the fur fps/fes complex on chromosome 15. Clonal integration of HIV has now been demonstrated in 15 HIV-associated lymphoproliferations (3 lym
Suppression of hematopoietic support function is associated with overexpression of IL-4 and TGF beta 1 in LP-BM5 MuLV infected stromal cell lines (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1184 1995. Unique Identifier : AIDSLINE ICDB/95608961; Tse KF; Morrow JK; Hughes NK; Gallicchio VS; Univ. of Kentucky Medical Center, Lexington, KY 40536; Murine acquired immunodeficiency syndrome (MAIDS) induced by defective LPBM5 murine leukemia virus is a disease which shares many similarities to human AIDS. The pathogenesis of MAIDS is currently not understood, but may involve the consequential effect of stroma infection in the bone marrow resulting in a defective h
Characterization of cell lines derived from fibromatous tumors of a human immunodeficiency virus type 2-infected baboon (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1208 1995. Unique Identifier : AIDSLINE ICDB/95608985; Blackbourn DJ; Herndier BG; Levy JA; University of California, San Francisco, CA 94143; The objective of these studies was to determine the histogenesis of fibromatous tumors from human immunodeficiency virus type 2 (HIV-2)-infected baboons. Two baboons with no evidence of simian retrovirus (SRV) infection were experimentally infected with HIV-2. These animals developed an extensive fibromatosis conditio
Changing clinical manifestation of pediatric African Burkitt's lymphoma? (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1375 1995. Unique Identifier : AIDSLINE ICDB/95609152; Bamgbola FO; Yakubu AM; Ogala WN; Ifere OA; Bangbola NR; A.B.U. Teaching Hospital, Zaria, Nigeria; In a recent retrospective study within a period of 18 months, we saw relatively more cases of atypical clinical manifestations (ACM) of African Burkitt s lymphoma (ABL) than were seen in 14 years of medical practice in our unit or ever reported from Nigeria . Out of 15 patients wit
Immunization to oncogenic HER-2/neu protein with peptide based vaccines (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1498 1995. Unique Identifier : AIDSLINE ICDB/95609275; Disis ML; Gralow JR; Bernhard H; Hand S; Cheever MA; Medical Oncology, Univ. of Washington, RM-17, Seattle, WA 98195; Studies from our laboratory have shown that HER-2/neu (c-erbB-2) protein is a tumor antigen. Some patients with breast cancer have existent antibody and CD4+ T cell responses against the protein. The detection of existent immunity to HER-2/neu was surprising, since HER-2/neu is a self protein and immunological toler
3'-Azido-2',3'-dideoxythymidine (AZT) preferentially incorporates into liver mitochondrial DNA of CD-1 mice dosed with AZT in drinking water for 28 days (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2113 1995. Unique Identifier : AIDSLINE ICDB/95609888; Olivero OA; Fullerton NF; Beland FA; Poirier MC; NCI, NIH, Bethesda, MD 20892-4255; Liver mitochondrial DNA is a target for toxicity of some nucleoside analog drugs including 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodouracil (5-FIAU). AZT , the thymidine nucleoside analog used in the therapy of AIDS (acquired immunodeficiency
In vitro toxicity of anti-HIV dideoxynucleosides in human and rat myocytes (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2192 1995. Unique Identifier : AIDSLINE ICDB/95609967; Schmid SM; Coffield RT; Harwell JE; Gordon DG; Osborn BL; Tomaszewski JE; Page JG; Southern Research Inst., Birmingham, AL 35255; Chemotherapeutic-induced cardiomyopathy presents significant adverse effects limiting clinical utilization. In an effort to screen potential new agents prior to testing in animal models, we have employed in vitro myocardial assays with myocytes. Rat pup myocytes (Sprague-Dawley and Fisher 344), and a transformed human
Structure determination of Pneumocystis carinii dihydrofolate reductase complex (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2429 1995. Unique Identifier : AIDSLINE ICDB/95610203; Cody V; Galitsky N; Luft JR; Pangborn W; Hauptman-Woodward Medical Research Inst., Inc., Buffalo, NY 14203; Pneumonia caused by opportunistic infectious agents is a major cause of mortality among patients with AIDS. Antifolates have been shown effective against the dihydrofolate reductase (DHFR) from Pneumocystis carinii (Pc) which is a target for drug design studies. Crystals of recombinant Pc DHFR ternary complex with the
Plasma- and serum-protein binding of antisense oligodeoxynucleotide phosphorothioates in experimental animals and humans (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2451 1995. Unique Identifier : AIDSLINE ICDB/95610225; Zhang X; Lu Z; Diasio RB; Jiang Z; Tan W; Agrawal S; Zhang R; Dept. of Pharmacol. and Toxicol., Univ. of Alabama, Birmingham,; AL 35294; The use of antisense oligonucleotides targeted to mRNA represents an attempt at specific, genetically based therapy. In continuation of our studies in developing antisense oligonucleotides as therapeutic agents for AIDS, we have designed several antisense oligodeoxynucleotide phosphorothioates that have been shown to
Molecular interactions between the HTLV-1 Tax oncoprotein and the NF-kappa B-kappa B/I-kappa B regulatory proteins (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A3145 1995. Unique Identifier : AIDSLINE ICDB/95610918; Hiscott J; Lacoste J; Crepieux P; Petropoulos L; Jackson D; Beauparlant P; Pepin N; Lin R; Lady Davis Inst., McGill Univ., Montreal, Quebec H3T 1E2, Canada; Human T-cell leukemia virus type 1 (HTLV-I) is the etiologic agent of adult T-cell leukemia, an aggressive and fatal leukemia of CD4+ T cells. The oncogenic potential of HTLV-I resides in the 40-kD viral Tax oncoprotein which has been characterized as a strong trans-activator of viral transcription. One of the targets
FAS-independent cell death of HTLV-1-specific clonal cytotoxic T cells upon exposure to autologous HTLV-1-bearing leukemic cells (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 14:A20 1995. Unique Identifier : AIDSLINE ICDB/95613176; Anderson B; Maeda H; Maeda Y; Lam L; Yang Y; Mitsuya H; NCI, Bethesda, MD 20892; HTLV-l-specific clonal cytotoxic T cells (CTL) were generated from a patient with adult T-cell leukemia (ATL). The CTL killed autologous leukemic cells (ALC); however, the coculture resulted in decreased proliferation and death of the CTL. We explored the possible mechanisms of this CTL cell death. Coculture of CTL an
Enteral supplementation and lifestyle intervention. Implications in the treatment of wasting syndrome in patients with HIV disease.: AIDS Patient Care. 1995 Feb;9(1):18-9. Unique Identifier : AIDSLINE AIDS/95285191; May SH
Physical symptoms and psychological distress among patients with HIV infection.: AIDS Patient Care. 1995 Feb;9(1):28-31. Unique Identifier : AIDSLINE AIDS/95285192; Gil F; Arranz P; Lianes P; Breitbart W; Medical Oncology Service, Hospital Universitario 12 de Octobre,; Madrid, Spain.; There are many questions about the relationship between HIV-related symptoms and psychological distress, and how this relationship affects the immunological and clinical stage of illness. This article reviews the most recent research studies in this field, and encourages new research projects which will help in the ma
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS [letter]: AIDS Patient Care. 1995 Feb;9(1):3. Unique Identifier : AIDSLINE AIDS/95285193; Bihari B
Home access HIV test [letter]: AIDS Patient Care. 1995 Feb;9(1):3. Unique Identifier : AIDSLINE AIDS/95285194; Strub SO
Incorporating the Betty Neuman Systems Model into HIV clinical practice.: AIDS Patient Care. 1995 Feb;9(1):37-9. Unique Identifier : AIDSLINE AIDS/95285195; Miner J; Department of Ambulatory Care, Queens Hospital Center, Jamaica,; NY, USA.
Adjunctive corticosteroid therapy. Examining its role as a risk factor for cytomegalovirus pneumonitis in patients with AIDS.: AIDS Patient Care. 1995 Feb;9(1):4-6. Unique Identifier : AIDSLINE AIDS/95285196; Weinberg BJ; DiCostanzo D; Rosen MJ; Division of Pulmonary and Critical Medicine, Beth Israel Medical; Center, New York, NY, USA.
Phase I trial for AG1343 [news]: AIDS Patient Care. 1995 Feb;9(1):40. Unique Identifier : AIDSLINE AIDS/95285197
Trial data available [news]: AIDS Patient Care. 1995 Feb;9(1):40. Unique Identifier : AIDSLINE AIDS/95285198
Growth hormone adds weight [news]: AIDS Patient Care. 1995 Feb;9(1):41. Unique Identifier : AIDSLINE AIDS/95285199
Alternative Medicine Center created [news]: AIDS Patient Care. 1995 Feb;9(1):41-2. Unique Identifier : AIDSLINE AIDS/95285200
Clarithromycin for MAC [news]: AIDS Patient Care. 1995 Feb;9(1):42. Unique Identifier : AIDSLINE AIDS/95285201
IV pentamidine prophylaxis for PCP [news]: AIDS Patient Care. 1995 Feb;9(1):42. Unique Identifier : AIDSLINE AIDS/95285202
New TB drug approved [news]: AIDS Patient Care. 1995 Feb;9(1):42. Unique Identifier : AIDSLINE AIDS/95285203
FDA Blood Products Advisory Committee evaluates glove use in blood donation centers [news]: AIDS Patient Care. 1995 Feb;9(1):43. Unique Identifier : AIDSLINE AIDS/95285204
Expanded TB control program reduces hospital's TB skin conversion rates [news]: AIDS Patient Care. 1995 Feb;9(1):44. Unique Identifier : AIDSLINE AIDS/95285205
AIDS patent library on Internet [news]: AIDS Patient Care. 1995 Feb;9(1):45-6. Unique Identifier : AIDSLINE AIDS/95285206; Makulowich JS
AIDS aware.: AIDS Patient Care. 1995 Feb;9(1):49-53. Unique Identifier : AIDSLINE AIDS/95285207
Costs of terminal care for people with AIDS.: AIDS Patient Care. 1995 Feb;9(1):7-9. Unique Identifier : AIDSLINE AIDS/95285208; Bennett CL; Lubeck DP; McShane DJ; Mathews JK; Lipil WH; Department of Medicine, Lakeside Medical Center, Chicago, IL,; USA.; Despite the numerous studies on the costs of AIDS, little has been reported on the economic costs for terminal care. This study reports on the average monthly costs of care used in the last 6 months of life by a group of people with AIDS between 1984 and 1990. Hospital and outpatient visits, laboratory results, and me
Bill would end HIV prevention, 11 other programs and let states decide how to spend the money. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):1, 10. Unique Identifier : AIDSLINE AIDS/95700160; Under legislation proposed by Republican Senator Nancy Kassebaum (Kansas), decisions on how to spend Federal funds for HIV prevention and tuberculosis control would be shifted to the states. Kassebaum said that transforming the twelve categorical Centers for Disease Control and Prevention (CDC) grant programs into a s
Gingrich vows to hold hearing to block use of gay themes in AIDS programs. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):1-2. Unique Identifier : AIDSLINE AIDS/95700161; House Speaker Newt Gingrich announced that a Congressional hearing will be held to determine whether Federally funded AIDS prevention programs promote homosexuality. Gingrich told members of a town meeting that he had evidence that Federally funded AIDS programs and public education programs were encouraging homosexua
Study questions increasing cost of intensive care of pneumocystis. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):2. Unique Identifier : AIDSLINE AIDS/95700162; According to a new study, intensive care for AIDS patients with severe pneumonia is becoming so expensive that policy makers may decide to ration or refuse treatments. Researchers at the University of California-San Francisco (UCSF) found that it costs an average of $215,000 to extend by one year the life of an AIDS p
Government not liable for harassment of HIV-positive Job Corps trainee. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):3. Unique Identifier : AIDSLINE AIDS/95700163; A Federal Appeals Court ruled that a Job Corps trainee, harassed as a result of a supervisor s disclosure that he was HIV-positive, is not entitled to damages from the Labor Department. James Dorsey sued the government for monetary damages, alleging the Labor Department violated Section 504 of the Rehabilitation Act o
Court upholds firing of nurse who refused to treat HIV patient. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):3-4. Unique Identifier : AIDSLINE AIDS/95700164; A Federal appeals court has upheld the firing of a nurse who, because of her pregnancy, refused to care for an HIV patient. Pamela Armstrong, a nurse in the Home Care Services Division of Flowers Hospital in Dothan, AL, argued that exposure to an HIV-positive patient might harm her fetus even if she employed universal
Court says woman can't get ADA injunction unless discrimination persists. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):5. Unique Identifier : AIDSLINE AIDS/95700165; A Federal court ruling in Georgia limits a person s chances to obtain an injunction to deter AIDS-related discrimination. The decision raises questions about the ability to obtain injunctive relief under the Americans with Disabilities Act (ADA) in cases where the discrimination is alleged to have been caused by somet
No tie found between dentist with AIDS and infection of 28 of his patients. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):6. Unique Identifier : AIDSLINE AIDS/95700166; In 1990, health authorities concluded that Florida dentist David Acer infected several of his patients with HIV. But a study released in December, 1994, said there is no proof that a second Florida dentist infected 28 patients of his who have HIV. Researchers said the DNA in the dentist s HIV was dissimilar to that of
GAO faults Veterans Affairs for not promoting safer 'sharps' devices. General Accounting Office. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):7. Unique Identifier : AIDSLINE AIDS/95700167; The General Accounting Office (GAO), in a Congressional study, found that Veterans Affairs (VA) hospitals have a long way to go in preventing HIV infection through needlestick injuries. Although the number of punctures and cuts from needles, scalpels and other devices is reported to be declining, the GAO faults the VA
Red Cross offers tips for HIV education in government, business. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):8-9. Unique Identifier : AIDSLINE AIDS/95700168; The American Red Cross (ARC) has delivered workplace HIV/AIDS education to thousands of Federal and private-sector employees as a contractor since 1993. The ARC HIV/AIDS Workplace Program stresses the delivery of factual information about HIV/AIDS in a non-judgmental, culturally sensitive way. HIV transmission, preven
New York's watered-down AIDS curriculum doesn't please critics. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):9-10. Unique Identifier : AIDSLINE AIDS/95700169; A new AIDS curriculum for New York City junior high school students was adopted unanimously at the school board meeting on January 19, 1995. The curriculum, which stresses family values and promotes sexual abstinence as the best way of avoiding HIV, was not enough to satisfy the Roman Catholic Archdiocese, which objec
Inmate can't demand new cell because he fears cellmate has HIV. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Feb 10;10(2):11. Unique Identifier : AIDSLINE AIDS/95700170; A prison inmate s fear that his cellmate has HIV is insufficient to sustain a negligence lawsuit he filed against prison officials, a Federal judge has ruled. Tommy Jones, a pretrial detainee in a California county jail, said his health was in danger because he suspects his cellmate has HIV. The U.S. District Court Ju
Cofactors, coreceptors, and new retroviruses. An interview with Robin A Weiss, PhD. [interview by Mark Mascolini] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):6-10. Unique Identifier : AIDSLINE AIDS/95700205; Weiss RA; Dr. Robin A. Weiss, Director of Research at the Chester Beatty Laboratories of the Institute of Cancer Research in London, England presents his thoughts on the subjects of cofactors, coreceptors, and new retroviruses in HIV infection. Dr. Weiss responds to questions in the following areas: balancing basic research and
Sense antisense nonantisense. Can these novel antivirals knock HIV senseless? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):11-8. Unique Identifier : AIDSLINE AIDS/95700206; Chang HE; Mascolini M; Kraus Medical Partners, Clinical Research and Development, Los; Angeles, CA.; The authors examine the development, theories, research, and use of antivirals in the response to HIV infection and AIDS progression and address the question of how effective this novel approach may be. The article includes discussions that detail the antisense and triple helix candidates for HIV and related condition
Cutaneous fungal infections in HIV/AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):19-23. Unique Identifier : AIDSLINE AIDS/95700207; Cockerell, CJ; University of Texas, Southwestern Medical Center, Dallas, TX.; Various cutaneous and mucocutaneous manifestations that are associated with HIV infection and AIDS from the superficial Candida albicans to systemic infections such as that caused by Histoplasma capsulatum are discussed. Specific topics cover superficial fungal infections such as blastomycosis,
An interview with Ronald O. Valdiserri, MD. [interview by Barry Raine] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):25. Unique Identifier : AIDSLINE AIDS/95700208; Valdiserri RO; Dr. Ronald O. Valdiserri, deputy director of the Division of STD/HIV Prevention at the Centers for Disease Control and Prevention (CDC) in Atlanta, remembers the reactions he had during the period when his brother Edwin, a psychiatrist, was ill with AIDS. Similar to other periods in the life of these twins, it was a t
Official urges Persian Gulf states to blacklist AIDS patients. [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):27. Unique Identifier : AIDSLINE AIDS/95700209; Mardini A; Persian Gulf countries still stigmatize people with AIDS (PWAs) and single them out for punishment. Dubai s police chief, Brigadier Khahi Khalfan Tamim, recently recommended blacklisting PWAs to the Gulf Cooperation Council and recommended enacting tougher legislation in dealing with PWAs who knowingly spread the dise
400 million condoms diverted to toy manufacturers in India. [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):27. Unique Identifier : AIDSLINE AIDS/95700210; Mehta J; Half of the condoms intended for controlling the spread of AIDS in India are being used by toy manufacturers for other purposes. India s National AIDS Program, funded by the World Bank, has not used the money that is earmarked for anti-AIDS efforts. Delays in handing over the money
AIDS blamed for increase in Tanzanian tuberculosis cases. [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Int Assoc Physicians AIDS Care. 1995 Feb;1(1):27. Unique Identifier : AIDSLINE AIDS/95700211; Nuhu A; A rising case load of tuberculosis (TB) in Tanzania is being blamed on HIV/AIDS, according to the manager of the country s TB and leprosy control program. Tanzania s Health Ministry estimates that 1.5 million Tanzanians are HIV-positive, a figure expected to double by the year 20
House panels vote to kill HOPWA, prune Ryan White and CDC funds. Centers for Disease Control and Prevention. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):1-3. Unique Identifier : AIDSLINE AIDS/95700212; AIDS activists were surprised by the depth of the House of Representative s proposed cutbacks in several AIDS programs, including the killing of the Housing Opportunities for People with AIDS (HOPWA) program, the Ryan White Comprehensive AIDS Resources Emergency (CARE) Act, and the Centers for Disease Control and Prev
Women seek greater influence in research, prevention policies. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):1, 8-9. Unique Identifier : AIDSLINE AIDS/95700213; HIV-positive cases among women are rising at such a rapid rate that by the year 2000, AIDS will be the second greatest killer of women between the ages of 18 and 44, surpassing heart disease and accidents. Womens needs, however, are being largely ignored in the fight against this disease. Recently,
Nursing provider wins payment for services to AIDS patient. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):3. Unique Identifier : AIDSLINE AIDS/95700214; Blue Cross/Blue Shield of Alabama refused to pay claims for nursing care provided by Florence Nightingale Nursing Service. The Nursing Service administered care to an AIDS patient whose employer provided health benefits through a plan that covered charges for private-duty nursing but not custodial care. The Nursing Se
Federal law protects AIDS patients on managed-care plan, judge rules. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):4. Unique Identifier : AIDSLINE AIDS/95700215; A managed-care plan physician was sued by his AIDS patient under the Rehabilitation Act and the Americans with Disabilities Act (ADA). The patient argued that his physician treated him like an outcast because he was HIV-positive and that the doctor never made any bona fide medical judgments about his condition. The do
Houston man with AIDS loses job after co-workers vote to expel him. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):5. Unique Identifier : AIDSLINE AIDS/95700216; An employee sued a Houston machine shop that held a companywide vote culminating in the firing of the employee because he had AIDS. The lawsuit contended that the employee was able to perform his duties at the shop and that the shop had violated the Texas Health and Safety Code by disclosing his AIDS illness to his co
All pregnant women advised to get HIV test, consider AZT therapy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):6-7. Unique Identifier : AIDSLINE AIDS/95700217; The Centers for Disease Control and Prevention (CDC) advises that all physicians counsel pregnant women to get HIV tested to reduce the risk of HIV transmission to the child. The recommendation was prompted by a report that early use of the antiviral drug zidovudine (
Judges can't be sued for ignoring expert advice on AIDS transmission. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):7. Unique Identifier : AIDSLINE AIDS/95700218; A Federal judge said that Lawyer Lynn Frank Plemmons, presiding in a custody dispute, cannot be sued for refusing to hear testimony that custody should not be limited because the mother s uncle has AIDS. Plemmons, acting as special chancery judge, was sued under the Americans with Disabilities Act (ADA) which bars dis
Officials, participants oppose mandatory tests for pregnant women. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):9. Unique Identifier : AIDSLINE AIDS/95700219; Republican lawmakers in Congress were planning to introduce legislation for mandatory HIV testing of pregnant women, however, Clinton administration officials fear such mandatory testing will cause women to avoid prenatal care. Patricia Fleming, National AIDS Policy Director, tells of three studies showing pregnant wo
Government officials say needle-exchange programs curb HIV. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):9. Unique Identifier : AIDSLINE AIDS/95700220; Support is growing among Federal officials for lifting bans on needle-exchange programs, as evidenced during the February 22nd HIV Infection in Women Conference. Although government scientists have recommended this ban, Clinton administration officials have not acted upon it fearing that allowing needle-exchange progr
AIDS policy chief Fleming outlines progress achieved, challenges ahead. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 10;10(4):10-1. Unique Identifier : AIDSLINE AIDS/95700221; Patricia S. Fleming, National AIDS Policy Director, addressed the HIV Infection in Women Conference in February 1995 about the progress made to improve HIV care for women and the difficult challenges that must be confronted in the years ahead. Fleming states that womens health in general, and HIV in particular, is be
Rethinking HIV prevention strategies for gay men. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Focus. 1995 Feb;10(3):1-4. Unique Identifier : AIDSLINE AIDS/95700280; Gold RS; Deakin University, School of Psychology, Victoria, Australia.; For many gay men there is not a safe sex culture. In fact, the incidence of unsafe sexual behavior remains disturbingly high. This raises questions about the effectiveness of our current approach to behavior change interventions for the prevention of HIV infection. Three studies were designed to investigate factors th
Gay community links and safety. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Focus. 1995 Feb;10(3):5-6. Unique Identifier : AIDSLINE AIDS/95700281; Gold RS; Deakin University, School of Psychology, Victoria, Australia.; Links to the gay community may strengthen the resolve of those with a strong orientation towards safe sex, but weaken it for those without this resolve. Four Australian studies found statistically significant correlations between unprotected anal intercourse and links to the gay community. The samples from these studi
Thalidomide, the FDA, and us -- what do you have? Underground compassionate use. Food and Drug Administration. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Notes Undergr. 1995 Winter;(no 29):1-3, 8. Unique Identifier : AIDSLINE AIDS/95700301; It comes as no surprise to those in the underground that thalidomide, a TNF-inhibitor, is still defined by its teratogenicity, or ability to cause birth defects. In the late 1950s, thousands of babies were born with horrific birth defects after a company started marketing the drug as safe for morning sickness. Forty y
Roxithromycin. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Notes Undergr. 1995 Winter;(no 29):3-4. Unique Identifier : AIDSLINE AIDS/95700302; The PWA Health Group now distributes roxithromycin (Ruclid) for cryptosporidiosis. Cryptosporidium parvum is a single-cell parasite that produces chronic watery diarrhea in people with compromised immune systems. Roxithromycin, a macrolide antibiotic, currently is used extensively in Europe and Latin America to treat
KS update. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Notes Undergr. 1995 Winter;(no 29):4. Unique Identifier : AIDSLINE AIDS/95700303; The Food and Drug Administration ( FDA ) has recently granted accelerated approval to Liposome Technology, Inc., to market DOX-SL for people with AIDS with refractory Kaposi s sarcoma (KS). DOX-SL, an intravenous drug, is a new form of a regular cancer
PML and a tale of two drug companies. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Notes Undergr. 1995 Winter;(no 29):4-6. Unique Identifier : AIDSLINE AIDS/95700304; PML is a rare disease that destroys myelin tissue in the central nervous system and causes lesions in the brain. Probably caused by the JC virus, the disorder can proceed rapidly. Currently there is no treatment for PML. However, Dr. Khalili at Thomas Jefferson University published research showing that topotecan, an
Essiac. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Notes Undergr. 1995 Winter;(no 29):6-7. Unique Identifier : AIDSLINE AIDS/95700307; Majchrowicz MA; Essiac, an herbal formulation from the Ojibway Indians in Canada , is composed of four herbs: burdock root, sheep sorrel, turkey rhubarb root, and slippery elm bark. After her discovery of Essiac in 1922, Rene Caisse reported treating and curing hundreds of people with cancer and ot
Gene transfer trial. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):2. Unique Identifier : AIDSLINE AIDS/95700309; A new gene therapy called HIV-IT is in clinical trials for the treatment of HIV infection. HIV-IT therapy deposits two genes (env and rev) that eventually attach themselves to the outside of healthy cells, and in doing so, hopefully boost the immune response that kills infected cells. A larger trial is now enrolling a
Bowel syndrome. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):3. Unique Identifier : AIDSLINE AIDS/95700310; A new outpatient trial is studying glutamine as a treatment for leaky bowel syndrome associated with HIV infection. Participants will be given urine tests and a 15 to 20 minute biopsy which is done by swallowing a small capsule (after numbing the throat) to see if it goes into the intestine; the capsule is then pulled
New drug for CMV in trials. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):3. Unique Identifier : AIDSLINE AIDS/95700311; Two new trials are studying treatment of CMV retinitis with an antisense drug called ISIS 2922. This drug affects the way the CMV works, i.e., it may be able to destroy the virus without harming the patient. One study uses ISIS 2922 alone and the other combines
Good results from eye implant study. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):4. Unique Identifier : AIDSLINE AIDS/95700312; Researchers are studying the use of ganciclovir, administered by eye implants, for the treatment of CMV retinitis. Participants in a 1992/1993 study who had received the implant showed no progression of the disease while a no-implant comparison group suffered a
Treatment review. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):5. Unique Identifier : AIDSLINE AIDS/95700313; HIV patients experiencing eye problems should see an ophthalmologist experienced in examining and treating people with HIV. Studies are showing that effective treatments do exist for eye problems associated with HIV infection. For example, one treatment, Adatomed Silicone Oil, has been approved by the Food and Drug Ad
One person's story. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):6-7. Unique Identifier : AIDSLINE AIDS/95700314; An HIV-infected person describes his self-directed treatment for AIDS. He explains his feelings and physical manifestations from the use of treatments such as AZT , ddC , aerosolized pe
Salasalate for HIV. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):7. Unique Identifier : AIDSLINE AIDS/95700315; A newly opened trial is examining the use of salasalate, an aspirin-related drug without the adverse side effects to the stomach lining, for treatment of HIV infection. Participants will either be treated with the drug or a placebo, but neither the patient s doctor nor the participant will be told which is being admin
Protein diet study. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):7. Unique Identifier : AIDSLINE AIDS/95700316; A protein diet study comparing normal to restricted protein diets is seeking more participants. Potential participants must have stable weight. Dietary periods, which will require much lower (but safe) levels of protein intake than the Recommended Dietary Allowance guidelines, will last five days. Participants will al
Basic science and clinical trials: interview with William Paul, director of the Office of AIDS Research. [interview by John S James] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Feb 17;(no 217):1, 4-7. Unique Identifier : AIDSLINE AIDS/95700327; Paul W; William E. Paul, Director of the Office of AIDS Research (OAR) at the U.S. National Institutes of Health (NIH), responded to questions addressing public concern that his proposal for more basic AIDS research will reduce clinical trial research intended to find treatments. Dr. Paul clarified the role of small, rapid, d
AIDS clinical trials: why they have recruiting problems. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Feb 17;(no 217):1-4. Unique Identifier : AIDSLINE AIDS/95700328; Mirkin B; Enrolling the number of volunteers needed for clinical trials is a significant problem. There are generally two obstacles to enrollment in AIDS trials: the quality of the publicity and outreach efforts, and the design of the trials themselves. Drug companies efforts at maintaining secrecy for their new treatment drug
Valacyclovir study stopped -- worse survival. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Feb 17;(no 217):7-8. Unique Identifier : AIDSLINE AIDS/95700329; James JS; A study (ACTG 204) involving the effect of valacyclovir in preventing CMV disease in persons with advanced HIV infection (CD4 count under 100) was stopped because there were more deaths in the valacyclovir arm than in either (high dose/low dose) acyclovir arms o
AZT: pediatric study changed after worse monotherapy survival. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Feb 17;(no 217):8. Unique Identifier : AIDSLINE AIDS/95700330; The AZT arm of a pediatric study (ACTG 152) was halted early after the AZT-treated group showed worse survival than those in at least one of the comparison treatment groups. The double-blind study treated patients with either AZT alone, AZT with ddI,
Kaposi's sarcoma: DOX-SL approval recommended. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Feb 17;(no 217):8. Unique Identifier : AIDSLINE AIDS/95700331; The Food and Drug Administration ( FDA ) drug approval committee has recommended that DOX-SL be given accelerated approval for treatment of AIDS-related Kaposi s sarcoma (KS) in patients who have failed conventional treatment. This decision, coming after several votes against the drug s
Differential susceptibility of fresh human monocytes and cultured macrophages to HIV-1 infection in vitro.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:100 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291711; Sonza S; Maerz A; Lewin S; Mills J; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; We have investigated the susceptibility of peripheral blood monocytes to infection with HIV-1 in vitro. Although monocytes express high levels of CD4 on their surface on the day they are isolated, they are resistant to infection, measured by the production of p24 antigen. However, following some time in culture, they
Novel method for quantifying phagocytosis of Mycobacterium avium complex by monocytes in whole blood.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:101 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291712; Hewish M; Meikle A; Hunter S; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield, Vic.; Mycobacterium avium complex (MAC) is the most common cause of opportunistic bacterial infection in AIDS patients. We have developed a rapid assay for phagocytosis of MAC, with a view to detecting impairment of immune function in monocytes from HIV-infected donors. In this assay, fluorescein (FITC)-labelled MAC was inc
The C-terminal domain of HIV-1 Vpr causes cell growth arrest and structural defects.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:102 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291713; Azad A; Arunagiri C; Hewish D; Macreadie I; Biomolecular Research Institute, Parkville, Victoria.; OBJECTIVE: To determine the possible role of Vpr in AIDS pathogenesis by studying its effects on host cells. METHODOLOGY: Full length and truncated vpr genes were expressed in yeast cells and the effects of expression on cell growth, morphology and viability was studied. The effects of electroporation of synthetic C-t
Molecular epidemiology, genetic variation and phylogeny of HIV/SIV and HTLV/STLV.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:103 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291714; Saksena N; Virology Department, ICPMR, Westmead Hospital, NSW.; Currently, two human immunodeficiency viruses (HIV-1 and HIV-2) and six SIVs are recognised. Up to 50% of African green monkeys (AGMs) in their natural habitat are asymptomatic carriers of Simian Immunodeficiency Virus (SIV) and 30% of AGMs are naturally infected with Simian T-cell Leukemia Virus type-1 (STLV-1). Thus
Quantitative virology in assessment of a new anti-retroviral agent.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:104 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291715; Dwyer DE; Chang J; Dowton DN; Randle C; Armato T; Fordham MS; Cunningham AL; Department of Virology, ICPMR, Westmead Hospital.; Quantitative HIV isolation from plasma and PBMC, and quantitative RNA (plasma) and DNA (PBMC) PCR are the major ways of assessing reduction in viral load with new anti-retroviral therapy. Three Australian centres have enrolled 15 patients in an international multicentre trial of 100 patients with a new non-nucleoside
Comparison of the Quantiplex HIV-RNA branched chain (bDNA) assay and RT-PCR for determining HIV RNA in plasma samples from HIV-infected subjects and correlation with CD4 count.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:105 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291716; Dunne AL; Dowton DN; Dwyer DE; Cunningham AL; Hoy J; Mills J; Crowe SM; Macfarlane Burnet Centre for Medical Research, Fairfield.; AIM: As part of a QA program, we investigated the bDNA assay to determine its potential use in HIV quantitation of viral load. To confirm results, the same samples were quantitated by RT-PCR. Both quantitations were correlated with CD4 counts. METHODS: Patient (pt) plasma samples (n = 33) were prepared from blood coll
Documentation of patient report of exposure to HIV for cases of newly diagnosed infection attributed to exposures other than sex between men. National HIV Surveillance Committee.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:107 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291717; McDonald A; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW.; OBJECTIVE: To document exposure to HIV in cases of newly diagnosed HIV infection for which exposure had been attributed by the patient to sources other than sex between men. METHODS: Cases of HIV infection, newly diagnosed in Australia since January 1994 for which exposure to HI
The role of initial AIDS-defining illness in survival following AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:108 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291718; Luo K; Law M; Kaldor JM; McDonald AM; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; Sydney.; OBJECTIVE: To examine the role of initial AIDS-defining illness and trends over time in survival following AIDS. METHODS: Survival was calculated for all adult and adolescent AIDS cases (N = 3204) in Australia diagnosed through 1 November 1991 and reported to the National AIDS R
Prognosis of Kaposi's sarcoma as a primary and secondary AIDS defining illness.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:109 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291719; Padiglione A; Goldstein D; Law M; Kaldor J; Hoy J; Mijch A; Fairfield Hospital.; The natural history of Kaposis sarcoma (KS) as a primary presentation has been well defined but there is little known about prognosis following KS in subjects with a different primary AIDS defining illness (ADI). We analysed a consecutive series of 213 HIV positive individuals diagnosed with KS at Fairfield Hospital b
Hepatitis C prevalence, incidence and risk factors among injecting drug users in Sydney.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:110 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291720; van Beek I; Dwyer R; Kaldor JM; Kirketon Road Centre, Kings Cross.; OBJECTIVE: To measure hepatitis C virus (HCV) prevalence, incidence and risk factors among injecting drug users (IDUs). METHODS: The prevalence of HCV infection at first test was calculated for all IDUs attending KRC from February 1992 to July 1994. Incidence was calculated using the person years method for all IDUs r
Role of fine needle aspiration in HIV disease.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:111 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291721; Binotto E; Kelly M; Torda A; Lloyd A; Jones P; Dwyer J; Warren B; Cooke B; Dept. of Pathology, Prince Henry Hospital, Little Bay, NSW.; AIM: To review the diagnostic usefulness of fine needle aspiration (FNA) in HIV infected patients presenting with lymphadenopathy or other masses. METHOD: The case records of HIV patients having FNA between 1/93 and 7/94 were retrospectively reviewed. Clinical history, result of FNA and impact of result of FNA on mana
The health care costs of HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:112 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291722; Hurley S; Kaldor J; Department of Biostatistics, University of Washington, Seattle; 98115, USA.; OBJECTIVE. To estimate rates of health service usage and costs for Australian men in different phases of HIV infection, and the lifetime cost attributable to HIV. METHODS. A prospective survey of 20 men in Phase 1 (CD4+ > or = 500 x 10(6)/l), 31 in Phase 2 (CD4+ or = 200 x 10(6)/l), 30 in Phase 3
Intestinal microsporidiosis due to Septata intestinalis in nine HIV-infected patients.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:114 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291723; Dore GJ; Field AS; Marriott DJ; Hing MC; Verre J; Harkness JL; Department of Microbiology, St. Vincent's Hospital, Sydney.; OBJECTIVE: To describe the clinical and pathological features of disseminated microsporidiosis due to the newly described species Septata intestinalis in nine HIV-infected patients. METHODS: Intestinal microsporidiosis was diagnosed by modified trichrome or uvitex 2B s
The diagnosis of appendicitis in patients with AIDS/HIV infection--four case reports.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:115 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291724; Hammett RJ; Edwards R; Kotsiou G; Pigott P; HIV Medicine Unit, Royal North Shore Hospital, St. Leonards,; N.S.W.; We present four case reports of HIV positive patients, presenting with acute appendicitis in whom there was a significant delay in the diagnosis of their presenting symptoms and signs. This, in turn, resulted in delays to the time of appendicectomy and led to prolonged hospitalisation and increased morbidity. All pati
Hypopyon panuveitis in patients with AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:116 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291725; McCluskey PJ; Hykin P; Pavesio CE; Towler HM; Lightman S; Department of Clinical Ophthalmology, Moorfields Eye Hospital,; London, England.; OBJECTIVE: to describe the clinical and microbiological features of a group of five patients with AIDS presenting with 13 episodes of acute endophthalmitis possibly associated with the use of rifabutin. DESIGN: A retrospective review of medical records and a series of polymerase chain reactions using stored aqueous an
Evaluation of results and clinical utility of bone marrow examination in patients with HIV.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:117 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291726; Torda A; Jones PD; Beale P; Department of Infectious Diseases, Prince Henry Hospital, Little; Bay, NSW.; AIM: To examine the experience at this hospital of bone marrow (BM) examinations in patients with HIV and assess the clinical indications for which this procedure had the highest yield. METHODS: Case records of forty patients who had a total of fifty-one BM examinations between January 1993 and February 1994 were revi
Chronic cough in HIV--a retrospective review.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:118 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291727; Hammett RJ; Pigott P; Department of HIV Medicine, Royal North Shore Hospital,; University of Sydney, St. Leonards, N.S.W.; We present eleven HIV positive patients who were referred to our unit for investigation of chronic cough. The spectrum of diagnoses, the utility of investigations and the efficacy of treatment in the setting of the different conditions is discussed. All patients had cough and/or dyspnoea which had been present for at
Implantable venous access device infections in patients with AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:119 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291728; Hellard ME; Pickles R; Fuller A; Spelman D; Alfred Hospital, Melbourne.; Totally implantable central venous access devices (trade name--Infusaport [IFP]) are used increasingly in AIDS patients for home and inpatient therapy. This report reviews the number of IFP s implanted in patients from the Alfred Hospital Infectious Diseases Unit between January 1992 and June 1994, and the incidence a
Women, drug use and heterosexual sex.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:121 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291729; Berg R; This paper reports on a survey of 300 drug using women, addressing the negotiation of safe heterosexual sex. The study examines condom use in relation to intoxication and addiction, sex work, perception of risk, relationships and short term partners and the meanings attached to condom use. The results highlight severa
Friends and lovers: needle sharing in young people injecting drugs in Western Australia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:122 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291730; Loxley W; Ovenden C; National Centre for Research into the Prevention of Drug Abuse,; Perth, Western Australia.; The Youth AIDS and Drugs (YAD) Study is a study of young people who inject drugs, and their risk of the transmission of HIV through needle sharing and/or unsafe sex. One hundred and five people, aged less than 21, 75% of whom were injectors, undertook in-depth interviews which were tape recorded, transcribed and analy
Dying at home: the experience of four villages in northeast Thailand.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:123 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291731; Bennett E; Salazar F; Williams A; Himmavanh V; Charerntanyarak L; Tropical Health Program, Medical School, University of; Queensland, Herston.; In Thailand , increasing numbers of people are expected to die at home as the HIV/AIDS epidemic progresses, but there is little information about the issues surrounding death and dying. This study, conducted in 1994, used qualitative methods to describe the health care patterns, do
Transitions and AIDS: a report on research in progress.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:124 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291732; Raphael B; Viney L; O'Loughlin B; McLean S; Woolcock G; Stephens D; National Centre for HIV Social Research, Melbourne Research; Group, Parkville, Vic.; AIMS: 1. To identify and describe the personal and social processes of transition from being HIV positive and well, to living with and dying from AIDS. 2. To identify the themes and nature of this transition, in terms of the affected person, their personal and social relationships and their health care providers. 3. To
Sydney men and sexual health: negotiated safety in a cohort of homosexually active men.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:125 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291733; Prestage G; Kippax S; Noble J; Crawford J; Cooper D; Baxter D; National Centre in HIV Social Research, Darlinghurst, NSW.; Sydney Men and Sexual Health (SMASH) is a cohort study of 903 homosexually active men involving an initial interview, with follow-up interviews every six to twelve months and clinical tests. Data collected includes HIV sero-status, knowledge of HIV, personal relationships, safe and unsafe sexual behaviour, contact wito
Ways of living with HIV: a two year study of HIV+ young men.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:126 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291734; Goggin M; Western Australian AIDS Council, Perth.; Based on a questionnaire and interview responses from 130 HIV positive young men followed over a two year period, four different ways of living with HIV are identified which remain flexible and changeable over time. These four different adaptive lifestyles were: 1. Lost & Isolated, young men find it difficult to co
Choosing to die. Breaking the silence.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:128 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291735; Van Reyk P; Lesbian & Gay Anti-Violence Project, Darlinghurst, NSW.; In 1994, the AIDS Council of NSW undertook the production of a booklet on euthanasia. This was in response to two needs: the need for people wishing to choose euthanasia to have easily accessible information on how to make such a decision and on the likely consequences of their actions; and the need for practitioners
Patients who express a wish to die: how does the palliative care physician approach such requests?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:129 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291736; Glare P; Royal Prince Alfred Hospital, Camperdown, NSW.; A small percentage of the approximately 1000 patients referred to the Central Sydney Area Palliative Care Service (based at Royal Prince Alfred Hospital) each year express a wish to die on first medical consultation. Many change their attitude to their lives in the course of subsequent palliative care interventions. B
Euthanasia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:130 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291737; Moore M; ACT Legislative Assembly, Canberra.; In 1991 I raised the issued of active euthanasia for debate in the first ACT Legislative Assembly as a Matter of Public Importance. That issue was debated at length at the time and then became part of my policy prior to the 1992 Election. In 1993 I presented to the ACT Legislative Assembly the Voluntary and Natural De
Assisted suicide, euthanasia, AIDS & the law.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:131 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291738; Magnusson RS; Faculty of Law, University of Melbourne.; Assisted suicide and euthanasia are currently the subject of vigorous community debate. Polls reveal a high level of public support for law reform, and a number of doctors have recently publicly admitted to hastening death. Issues of assisted suicide and euthanasia are particularly relevant within the HIV community, p
Multiple opportunistic pathogen prophylaxis (MOPP): an overview.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:133 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291739; Jacobson MA; University of California, San Francisco, USA.; Patients with CD4 counts
Prophylaxis and treatment of opportunistic viral infections in patients with HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:134 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291740; Mills J; Macfarlane Burnet Centre for Medical Research/National Centre in; HIV Virology Research, Fairfield, VIC.; Reactivations of HSV infections are easily managed by treatment or chemosuppression with acyclovir (ACV); whether the ACV prodrug (valaciclovir) will be better for this indication is uncertain. Rare patients (prob.
Problems with emerging azole resistance in the management of AIDS related fungal infections.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:135 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291741; Ellis D; Mycology Unit, Women's and Children's Hospital, North Adelaide.; The emergence of AIDS has been responsible for a dramatic increase in human fungal infections, especially those caused by the yeast-like fungi Candida and Cryptococcus. These infections are essentially incurable and the basic aim of current treatment regimes is to eliminate or control the clinical symptoms for the dur
The economics of prophylactic therapy.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:136 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291742; Pinching AJ; Department of Immunology, Medical College of Saint Bartholomew's; Hospital, West Smithfield, London, UK.; The AIDS patient, with profound and progressive cell-mediated immunodeficiency, presents a prospect of substantial morbidity and mortality due to severe opportunist infections. The clinical goal is to minimise HIV replication to ameliorate the rate at which immune defences are eroded and to maximise immune and other d
AIDS in Australia: have we reached the peak?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:138 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291743; Luo K; Law M; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Sydney.; OBJECTIVE: To estimate the past HIV incidence curve and predict future AIDS incidence in Australia . METHODS: Estimates of HIV and AIDS incidence were obtained using the statistical method of back-projection which reconstructs the epidemic based on the observed AIDS incidence and
The relationship of HIV and other STDs in Australia: setting priorities for control strategies.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:139 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291744; Bowden FJ; Northern Territory AIDS/STD Programs, NT Department of Health and; Community Services, Casuarina.; There is now reasonably good evidence for the existence of a relationship between the presence of a pre-existing STD and an increase in the risk of transmission or acquisition of HIV during sexual intercourse. This relationship (sometimes referred to as epidemiological synergy) is likely to be an important feature of
Premature mortality in Australia 1983-1992: the first decade of the AIDS epidemic.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:140 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291745; Gold J; Li Y; Kaldor J; Albion Street Centre, Surry Hills, NSW.; OBJECTIVE: To determine the trends in years of potential life lost (YPLL-75), before the age of 75 years, due to selected causes of death in Australia and in selected States for the whole population and for adults aged 25 to 44 years. DESIGN: Australian Bureau of Statistics mort
Progression to AIDS: a comparison of Australian and overseas findings.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:141 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291746; Law MG; National Centre in HIV Epidemiology and Clinical Research, NSW.; OBJECTIVE: To estimate the incubation distribution, defined as the time from seroconversion to AIDS, in Australia . METHODS: Data were available from two sources. (1) A cohort of people aged 13 years or more with HIV infection from a blood transfusion. To limit bias in the estima
HIV in prison.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:142 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291747; Dolan K; National Drug and Alcohol Research Centre, UNSW, Sydney,; Australia.; It is difficult to conclusively prove that HIV transmission occurs in the prison setting. However evidence has started to emerge to indicate that a significant level of HIV transmission does occur in prison. The prison setting differs from the community in several ways that may actually facilitate HIV transmission. In
Implications of HIV infection for aboriginal and Torres Strait Islander peoples and their health and medical professionals.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:144 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291748; Noel J; Public Affairs Branch, Department of Human Services and Health,; Sydney.; The history of reaction to HIV infection amongst Australia s indigenous peoples is a chequered one, ranging from sporadic hysteria to a complacent malaise. The threat of infection and the potentially catastrophic social, personal and economic ramifications remain one of the most urgent and difficult challenges confron
HIV behind bars: the Canadian experience.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:145 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291749; Hankins C; Centre for AIDS Studies, Montreal Regional Public Health Team,; Quebec, Ca.; Correctional institutions have the highest HIV prevalence of any institutional setting in Canada . In December 1993, only 102 (0.8%) of 13084 federal inmates were known to have HIV and no unlinked studies had been done. Rates in provincial settings relate directly to the % of inmate
Lessons to be learnt from the Thai epidemic for the Australian audience/transition from IVDU to heterosexual epidemic.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:146 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291750; Sittitrai W; Program on AIDS Thai Red Cross Society, Bangkok.; OBJECTIVES: 1. To describe epidemiology of HIV/AIDS and risk behavior in Thailand and in reference to other Asian and Pacific countries. 2. To describe strategies and accessories for behavior change and the coping mechanisms for care for persons with AIDS in the Asian context. SU
Blood borne viruses in Australian IDUs: good news and bad news.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:147 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291751; Crofts N; Macfarlane Burnet Centre for Medical Research.; Continued low incidence of HIV infection among female and heterosexual male injecting drug users (IDUs) in Australia are reassuring, but subject to several cautions. We do not at present have sufficient quality routine survey or surveillance data among many groups of IDUs, and r
Risk factors for HIV among homosexually active men.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:148 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291752; Kippax S; Kaldor J; Crofts N; Hendry O; Notts P; Noble J; National Centre for HIV Social Research, North Ryde, NSW.; INTRODUCTION: In Australia , exposure to HIV for the majority of cases of newly diagnosed HIV infection has been attributed to male homosexual contact (85%). In this study homosexually active men who had recently seroconverted were compared with men who had not seroconverted in o
Interleukin 10 inhibits replication in monocytes and macrophages.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:151 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291753; Chang J; Naif H; Li S; Fear W; Ho-Shon M; Kesson A; Cunningham AL; Westmead Hospital, NSW.; Recent studies have shown that endogenous interleukin 10 (IL-10) produced either by IFN-gamma or LPS stimulated human monocytes, strongly inhibited the production of many proimflammatory cytokines at the transcriptional level. On the basis of marked immunoregulatory effects of IL-10 on monocytes, we investigated the b
Studies of cytokine activity in virus infection in vivo using recombinant viruses and cytokine gene knockout mice.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:152 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291754; Ramsay AJ; Ramshaw IA; Viral Engineering and Cytokine Research Group, John Curtin School; of Medical Research, Australian National University, Canberra.; Cytokines play a determinant role in antiviral immune responses both in the inductive and effector phases. We have used mice rendered deficient for the production of particular cytokines (GKO mice) and recombinant vaccinia viruses (rVV) encoding these factors in order to study some of the activities of cytokines in a
High level resistance to AZT in association with a leucine to tryptophan change at amino acid 210 of HIV-1 reverse transcriptase.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:153 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291755; Hooker D; Tachedjian G; Solomon A; Gurusinghe A; Land S; Birch C; Roy B; Tantillo C; Arnold E; Deacon N; AIDS Molecular Biology Lab, Macfarlane Burnet Centre for Med Res,; Fairfield Vic, Australia.; Nucleoside analogue drugs ( AZT , ddl, ddC ) used in the treatment of AIDS target the activity of the HIV-1 reverse transcriptase (RT). Long term treatment with these drugs leads to the
In vitro generation and characterisation of foscarnet-resistant HIV-1.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:154 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291756; Tachedjian G; Gurusinghe A; Hooker D; Deacon N; Mills J; Birch C; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; Foscarnet is a pyrophosphate analogue used in the treatment of CMV retinitis and acyclovir-resistant herpes simplex infections in AIDS patients. It is also an inhibitor of HIV-1 reverse transcriptase (RT), and therefore long-term administration in patients may ru
How do peptide inhibitors of viral fusion work?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:155 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291757; Curtain CC; Whittaker RG; Kirkpatrick A; Waring AJ; Gordon LM; Mobley PW; Department of Physics, Monash University, Clayton, Victoria.; It is well known that the membrane fusion process whereby viruses with lipid envelopes, such as HIV and related retroviruses, enter their target cell may be inhibited by oligopeptides with sequences homologous to those found in the fusion domain of the viral transenvelope protein. In some cases, the extent of fusion iu
Novel vaccine strategies using fowlpox viruses and plasmid DNA.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:156 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291758; Leong KH; Ramsay AJ; Boyle DB; Robinson HL; Ramshaw IA; Viral Engineering and Cytokine Research Group, JCSMR, Canberra.; We have studied avipox viruses encoding cytokine genes, both alone and in combination with naked DNA plasmids, as potential vaccine strategies. As these viruses abortively infect mammalian cells, yet still effectively present foreign genes to the immune system, they offer a safer but effective alternative to other livu
Demographic characteristics of Victorian women diagnosed with HIV.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:158 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291759; Robinson PM; Stevenson EM; Greet B; Public Health Branch, Department of Health & Community Services,; Melbourne.; OBJECTIVES: To describe characteristics surrounding diagnosis for Victorian HIV-infected women, including reason for test, health at time of diagnosis and means of infection. METHODOLOGY: Current surveillance mechanisms for HIV in Victoria includes data collection from HIV test request forms together with routine callu
Recent developments in national STD surveillance in Australia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:159 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291760; Rowbottom J; NCHECR, Darlinghurst, NSW.; INTRODUCTION: Monitoring of STD, other than HIV, is important in its own right, and provides information on sexual practices which may represent risk of HIV transmission. Additionally, some genital infections increase the risk of HIV transmission. A project to improve Australian surveillance for STD commenced in 1992.u
Men who have sex with men and inject drugs.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:160 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291761; Crofts N; Marcus L; Meade J; Sattler G; Sharp R; Epidemiology Unit, Macfarlane Burnet Centre for Medical Research,; Fairfield, VIC.; OBJECTIVE: to survey a wide spectrum of homosexual men who inject drugs, to inform the development of specific policy and programs for HIV prevention and provision of treatment services. METHODS: a cross-sectional survey of a wide spectrum of men who had ever had homosexual contact and who had injected an illicit drugu
Initiation into injecting: the first hit.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:161 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291762; Louie R; Crofts N; Rosenthal D; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; OBJECTIVES--(i) To determine how injecting drug users (IDUs) first begin to inject, (ii) to determine whether the manner of initiation influences subsequent injecting behaviour in relation to risk of HIV transmission, (iii) to determine whether a relationship exists between injecting and sexual risk and (iv) to determu
Patterns of serologic testing in HIV-1 seronegative men.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:162 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291763; Grunseit AC; Rodden P; Crawford J; Kippax S; National Centre for HIV Social Research, Macquarie University,; North Ryde, NSW.; OBJECTIVE: To study factors in the repeated use of the HIV-antibody test in 903 seronegative, homosexually active men from a 1992 national telephone survey who reported substantial use of the test. METHOD: Two sub-groups were defined & examined: The event-related (ER) group took the test when motivated by a particu
Changing patterns of sexual practice in response to HIV: a cross-sectional analysis of three samples of gay and homosexually active men in Australia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:163 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291764; Noble J; Kippax S; National Centre for HIV Social Research, Macquarie University.; This paper investigates the importance of gay community attachment in changing sexual practice by comparing three large samples of men who have sex with men (or homosexually active men). The 1986 Social Aspects of the Prevention of AIDS study (SAPA) and the 1993 Sydney Men and Sexual Health study (SMASH) used face to
Decay of transplacental human immunodeficiency virus type-1 (HIV-1) antibodies in neonates and infants.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:165 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291765; Palasanthiran P; Robertson P; Graham GG; Hughes C; Ziegler JB; Prince of Wales Children's Hospital, Randwick NSW, Australia.; Transplacental human immunodeficiency virus (HIV) antibodies from 11 uninfected and 3 infected infants of HIV seropositive mothers were quantitated using end point titration of twofold dilutions of sera by a particle-agglutination method (Serodia). 4 or more sequential sera from each infant collected between birth and
The safety and efficacy of sorivudine (BV-araU) for the treatment of zoster in HIV-infected adults: results of a multinational acyclovir controlled trial.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:166 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291766; Boag F; Bodsworth NJ; Burdge D; Genereux M; Barleffs JC; Evans B; Colebunders R; Modai J; Thomas M; Marcoccia J; et al; Kobler Centre, London.; Sorivudine (BV-araU) 40mg once daily was compared in a randomised double-blind trial to acyclovir 800mg five times daily for seven days for the treatment of acute localised zoster in HIV infected adults. Patients were seen daily until 100% crusting and on days 7,10,14 and 28 for
Filgrastim, CEOP and antiretroviral therapy in HIV-related non-Hodgkins lymphoma (NHL).: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:167 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291767; Goldstein D; Newell M; Milliken S; Lewis C; Hoy J; Thomson B; Dolan G; Ryan S; Sarr A; Cooper DA; Fairfield Hosp., Melbourne.; Cytotoxic chemotherapy is necessary for effective palliation in HIV-related NHL, however frequent delays and dose reductions occur due to increased myelosuppression which usually necessitates the discontinuation of antiretroviral therapy. Filgrastim has been shown to shorten the duration of neutropenic nadir from cyto
Sexual transmission of zidovudine resistant HIV-1. Sydney Primary HIV Infection Study Group.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:168 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291768; Imrie A; Carr A; Duncombe C; Vizzard J; Zheng N; Finlayson R; Hurren L; Roggensack M; Kaldor J; Penny R; et al; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.; HIV-1 with decreased in-vitro susceptibility to zidovudine (ZDV) may be isolated from patients on prolonged therapy. We examined the frequency with which ZDV resistant variants of HIV-1 were isolated from 27 homosexual men with primary HIV-1 infection (PHI), as well as from 5 sexual partners. ZDV susceptibility was as
H.I.V. autopsy pathology--an update.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:169 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291769; Duflou J; Hilton JM; NSW Institute of Forensic Medicine, Glebe.; Both coronial and non-coronial HIV positive autopsies have been performed at the NSW Institute of Forensic Medicine since early 1992. In 1993, we presented our findings of the first 35 autopsies. In a comparison with antemortem diagnoses, we noted clinically significant discrepancies in almost half of the cases studie
Pathology of the heart in the acquired immunodeficiency syndrome.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:170 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291770; Lawrence CH; Duflou J; Mathijs JM; Sears A; NSW Institute of Forensic Medicine, Glebe.; The acquired immunodeficiency syndrome (AIDS) may involve the heart in a number of ways, including primary HIV myocarditis/cardiomyopathy, opportunistic infections of the myocardium and valves, neoplasms involving the heart, and cardiac failure associated with the nutritional and wasting conditions linked to AIDS. In
Clinical predictors of the presence of dementia and neuropsychological impairment in HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:172 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291771; Dunbar N; Pemberton L; Perdices M; Brew B; National Centre for Epidemiology and Clinical Research,; University of New South Wales, Sydney.; OBJECTIVES: To investigate the ability of clinical, laboratory and demographic variables to predict the presence of dementia and neuropsychological impairment in patients with CD4 count
Neuropsychological characterization of the HIV associated dementia complex.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:173 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291772; Maruff P; Tyler P; Malone V; Wright E; Hoy J; Brew B; Currie J; Fairfield Infectious Diseases Hospital, Mental Health Research; Institute of Victoria.; OBJECTIVE: To investigate the neuropsychological deficits present in mild HIV associated dementia complex (HDC). METHOD: Subjects recruited from large metropolitan hospital out-patient clinics; all living independently in the general community. A comprehensive neuropsychological te
Subjective cognitive dysfunction, mood and activities of daily living as indicators of HIV associated dementia complex.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:174 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291773; Maruff P; Malone V; Wright E; Tyler P; Hoy J; Brew B; Currie J; Fairfield Infectious Diseases Hospital, Mental Health Research; Institute of Victoria.; OBJECTIVE: To examine the effect of HIV associated dementia complex (HDC) on activities of daily living, mood and self perceived cognitive dysfunction. METHODS: Patients with CD4 cells
The frequency of HIV-associated dementia complex in patients with CD4 cell counts less than 250mm-3.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:175 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291774; Wright E; Maruff P; Malone V; Tyler P; Hoy J; Brew B; Currie J; Fairfield Infectious Diseases Hospital, Mental Health Research; Institute of Victoria.; OBJECTIVE: To investigate (1) HIV-1 associated dementia complex (HDC) in HIV infected patients with CD4 cell counts
Pilot study of the efficacy of ateviridine in AIDS dementia complex (ADC).: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:176 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291775; Brew B; Dunbar J; Druett J; Freund J; Ward P; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst Sydney, Australia.; OBJECTIVE: To assess in a pilot study the efficacy of ateviridine (U-87201E, Upjohn Laboratories), a member of the BHAP class of antiretroviral drugs, in the treatment of ADC. METHODS: Ten ADC patients (combined neurological and neuropsychological impairment score > 4 (normal
Prospective analysis of HIV associated seizures.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:177 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291776; Dore G; Brew B; HIV Medicine Unit, St. Vincent's Hospital, Sydney.; OBJECTIVE: A prospective case-control study was undertaken to examine the causative factors for HIV-related seizures. METHODS: Patients under either inpatient or outpatient care of the HIV-medicine unit who had a documented seizure were included. Investigations included initial neurological examination, serum electrol
Home ambulatory therapy.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:179 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291777; Reilly M; Silver Chain Nursing Association, Osborne Park, WA.; Changes in the healthcare delivery system have created a competitive marketplace that demands new programmes to contain healthcare costs while providing more efficiently for clients healthcare needs. One major change is a trend toward home ambulatory therapy. The Special Services team of Silver Chain Nursing Associati
Nursing management of HIV/AIDS patient with Kaposi's sarcoma.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:180 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291778; Anderson S; Fairfield Hospital, VIC.; This paper will report on the nursing interventions within a multidisciplinary approach and the methodology used in the management of an HIV/AIDS patient with Karposi s Sarcoma who had received palliative radio therapy as a treatment modality to his left lower leg and foot. The multidisciplinary approach included dres
The human immunodeficency virus + malignancy = challenge.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:181 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291779; Davies H; HIV Ambulatory Care Unit, St. Vincent's Hospital Sydney Limited,; Darlinghurst.; The physical, psychological, emotional and spiritual pain experienced by many people diagnosed with a malignancy, their significant others and those who care for them, can be enormous. A diagnosis of cancer when made in an individual who has tested positive for the Human Immunedeficency Virus (HIV) comes as a double b
Nurse initiated continuous positive airways pressure in the management of severe Pneumocystis carinii pneumonia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:182 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291780; Sheard P; Clinical Nurse Educator HIV/AIDS Unit. St. Vincent's Hospital; Sydney Limited, Darlinghurst, NSW.; Inpatients with Pneumocystis carinii pneumonia (PCP) are assessed on admission by nurses for activities of daily living, vital signs and pulse oximetry. If observations indicate hypoxaemia then oxygen therapy is indicated. Oxygen therapy is administered to maintain a peripheral oxygen saturation of > 90%. Oxygen thera
Nursing care standards for people with HIV/AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:183 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291781; Paterson B; Hawkins A; Oncology & Cell Biology Institute, St Vincent's Hospital Ltd.,; Darlinghurst.; A Commonwealth AIDS Workforce Information, Standards and Exchange (CAWISE) Program grant was obtained to develop a resource manual for nurses to assist with the management of people with severe HIV disease/Acquired Immune Deficiency Syndrome (AIDS). Upon review of the literature the formulation of nursing care standar
Stepwise analysis of reverse transcription in a cell-to-cell HIV infection model: kinetics and implications.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:186 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291782; Karageorgos L; Li P; Burrell CJ; NCHVR, Division of Medical Virology, IMVS, Adelaide SA.; We have investigated the kinetics of human immunodeficiency virus (HIV) reverse transcription in infected T-cells, using a synchronized, one-step, cell-to-cell infection model and quantitative PCR assays for the different DNA intermediate structures that are found sequentially during reverse transcription. After an in
Mutually dependent synthesis and amplification of viral DNA and RNA early after cell-to-cell transmission of HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:187 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291783; Kok T; Li P; Burrell CJ; NCHVR, Division of Medical Virology, IMVS, Adelaide SA.; Using a one-step cell-to-cell transmission model of HIV infection it was shown that there were two distinct phases of HIV RNA synthesis. The first phase (4h-12h pi) was marked by a significant increase in only the full-length 9.2 kb RNA and the second phase (24h pi onwards) comprised a dramatic increase in the levels
The role of cytokines in immunity to murine retrovirus infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:188 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291784; Segal D; Ramsay A; Ruby J; Ramshaw I; Viral Engineering and Cytokine Group, John Curtin School of; Medical Research, ANU Canberra.; Cytokines have been shown to play a crucial role in coordinating and mediating antiviral immune responses. Recently it has been postulated that inappropriate patterns of cytokine production during HIV infection may inhibit protective immune responses and result in progression to AIDS. To investigate this idea further
A hu-PBL-SCID model to study HIV pathogenesis & therapy.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:189 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291785; Boyle MJ; Flanigan ME; Ford H Jr; Baseler M; Adelsberger J; Davey RT Jr; Lane CH; Laboratory of Medicinal Chemistry, NCI, N PRI/Dyncorp, Frederick,; MD, USA.; PBL from HIV infected patients were engrafted into CB-17 SCID mice to develop a novel small animal model for the study of HIV pathogenesis and therapy. Engraftment was achieved in 84% of mice, with human immunoglobulin (hu-lg) levels and total human mononuclear cell recovery by peritoneal wash (PW) similar to control
The CD4 of lymphoblastoid MT-2 cells appears in both monomeric and complex configurations.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:190 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291786; Lynch GW; Sloane A; Dearden M; Humphrey-Smith I; Cunningham A; Dept. of Virology, University of Sydney, Westmead Hospital, NSW,; Australia.; CD4 receptor is an essential molecule in the cellular recognition of foreign antigen presentation to T lymphocytes. CD4 also is the principal cellular receptor for the binding and infection of HIV to monocytes, macrophages and CD4+ lymphocytes. Transmembranous CD4 has up till the present been generally viewed as monom
CD4 expression is not related to HIV-1 in vitro infection of alveolar macrophages.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:191 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291787; Lewin SR; Sonza S; Irving L; McDonald CF; Mills J; Crowe SM; National Centre for HIV Virology Research, Macfarlane Burnet; Centre for Medical Research, Fairfield, Victoria.; The CD4 glycoprotein is the major cellular receptor for HIV. It has been reported by us and other groups that CD4 surface expression of monocytes decreases with time in culture while their susceptibility to HIV-1 increases. Our aim was to investigate whether this phenomenon occurs in macrophages that have differentiat
Belief in medicines and quality of life in end-stage AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:193 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291788; Cooney N; Sacred Heart Hospice, Darlinghurst, Sydney.; In the final stages of HIV/AIDS patients are often taking a considerable number of tablets or requiring intravenous therapies in order to control chronic AIDS-related infections. This paper reports a retrospective study of the use of medications in patients who died at a Sydney hospice that cares for a large number of
Structural issues in the provision of HIV/AIDS palliative care services.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:194 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291789; McGuckin R; Sacred Heart Hospice, Darlinghurst, NSW.; This presentation discusses the development of palliative care services for people with HIV/AIDS. It looks at how existing formal and informal service structures have adapted to the needs of this group; whether this adaptation has been adequate and appropriate; and the social, political, philosophical and economic fac
Willing decisions: experiences of using advance directives in the context of life threatening illness.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:195 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291790; Pettett M; St Vincent's Hospital, Sydney.; The paper explores the nature of advance directives and their use with people living with HIV/AIDS, in particular from a psychosocial perspective. Case examples will illustrate the value of both the process of preparing such a document, and the role that such a document can have in complex treatment decision scenarios
Burnout amongst HIV/AIDS health service providers--easy to catch, not so easy to treat!: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:196 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291791; Cass V; Burnout is a debilitating reaction to severe work stress which is commonly found amongst human service providers. Left undetected and/or untreated, it can result in psychological and physical symptoms such as emotional and physical exhaustion, withdrawal from others and poor decision-making ability. Reactions such as
Positive women and their sexuality.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:198 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291792; Hankins C; Centre for AIDS Studies, Montreal Regional Public Health Team,; Quebec, CA.; OBJECTIVE: To describe the impact of HIV+ test result on female sex life. METHODS: In confidential interviews, 161 women provided recall data for the 6 months before learning result, the post-test adjustment period, and the current month. RESULTS: Median age is 34 years (16-68) and median number of lifetime sex partne
Women and AIDS: lessons learned from Thailand.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:199 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291793; Sittitrai W; Program on AIDS Thai Red Cross Society, Bangkok.; OBJECTIVES: 1. To describe the epidemiology of HIV/AIDS among women in Thailand . 2. To describe the impact of HIV/AIDS on women. 3. To describe current and possible, future social and behavioural interventions which will benefit women. SUMMARY OF RESULTS: 1. the outbreak of HIV a
HIV disease in women: the Australian experience to date. National Working Group on HIV Infection in Women.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:200 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291794; Thackway SV; Furner V; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst.; OBJECTIVES: To provide a better understanding of the clinical manifestations of HIV disease in women in Australia . METHODOLOGY: Medical records of HIV positive women attending participating centres were reviewed and a six page data abstraction form completed. INTERIM RESULTS: To
Clinical challenges for positive women. National Working Group on HIV Infection in Women.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:201 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291795; Furner V; Thackway SV; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst.; OBJECTIVES: To provide a better understanding of the natural history of HIV disease in women in Australia , especially clinical manifestations and gynaecological conditions. METHODOLOGY: Medical records of HIV positive women attending participating centres were reviewed. INTERIM
Positive women and their doctors: accounts of women living with HIV/AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:202 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291796; Crawford J; Kippax S; Lawless S; National Centre for HIV Social Research, Macquarie University,; NSW.; OBJECTIVES: To explore HIV related issues specific to women as revealed in their accounts of interactions with medical practitioners. METHODOLOGY: In-depth interviews with HIV positive women. RESULTS: This paper represents work in progress from the Women Living with HIV and AIDS project. Data so far examined are based
Occupational issues for HIV care providers.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:205 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291797; Gerberding JL; University of California, San Francisco, USA.; Health care personnel risk exposure to bloodborne pathogens including HIV. Recent data suggest that patients may risk nosocomial infection with these same pathogens during invasive medical procedures. The average transmission risk associated with a discrete percutaneous exposure to HIV via a contaminated needle is .2%
Investigation of transmission of blood-borne viruses.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:206 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291798; Chant K; Public Health Unit, SWSAHS, Liverpool, NSW.; The potential for transmission of blood-borne viruses in settings with poor infection control practices has been well recognised. Today we are becoming increasingly aware of the potential for the transmission of blood-borne viruses in settings where infection control procedures are widely practised. This increasing aw
Nosocomial tuberculosis--strategies for prevention.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:207 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291799; Gilbert GL; Centre for Infectious Disease and Microbiology, Westmead; Hospital, NSW.; Nosocomial transmission from patients with open pulmonary tuberculosis (TB) is a recognized risk for health care workers (HCW) and other patients. It is uncommon with effective antituberculous therapy and limited periods of hospitalization. Recent outbreaks of nosocomial TB in the USA have been associated with: delaye
Inactivation of HIV: which disinfectant works?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:208 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291800; Druce J; Jardine D; Birch C; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital, Victoria.; The possibility of transmitting Human immunodeficiency virus (HIV) through accidental exposure to contaminated surfaces or equipment is a concern to all healthcare workers and others who have contact with HIV infected patients. An understanding of safe and effective disinfectants is important to all those working in t
Nosocomial tuberculosis outbreak in HIV infected patients at St. Vincent's Hospital, Sydney. TB Working Group.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:209 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291801; Couldwell D; Dore G; HIV Medicine Unit, St. Vincent's Hospital, Sydney.; OBJECTIVE: To investigate a possible outbreak of Mycobacterium tuberculosis infection in a HIV outpatient treatment facility. METHODS: Following the diagnosis of active pulmonary tuberculosis in a HIV-infected patient receiving outpatient intravenous therapy for CMV
Nosocomial transmission of AIDS-related opportunistic infections.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:210 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291802; Jones PD; Department of Infectious Diseases, Prince Henry Hospital, Little; Bay, NSW.; The nosocomial transmission of AIDS-related opportunistic infections has been highlighted by reports of transmission of tuberculosis from patient-to-patient and to health care workers. Nosocomial transmission of Cryptosporidium and scabies in AIDS units has also been reported. Opportunistic infections which may be tra
Clinical features and longterm follow-up of autoimmune polymyositis in HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:212 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291803; Gala S; Garcia R; Brew B; Stewart G; Department of Immunology, Westmead Hospital.; A 44 year old HIV-positive male was admitted in May 1992 for investigation of progressive muscular weakness and rising serum creatine phosphokinase (CPK). Symptoms of muscular weakness had developed over the preceding 2 months, and were accompanied by myalgia, lethargy, fatigue and malaise. Proximal myopathy was demon
Fulminant lymphomatoid granulomatosis presenting as meningitis--a case report.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:213 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291804; Hammett RJ; Smith AI; Parkin D; Pigott P; Herkes G; Evans W; HIV Medicine Unit, Royal North Shore Hospital, University of; Sydney, St. Leonards, N.S.W.; We present the case report and post-mortem findings of a 31 year old HIV positive male who died of cerebral Lymphomatoid Granulomatosis. The patient was diagnosed as HIV positive in November 1989. An episode of Pneumocystis pneumonia in 1991 was his AIDS defining illness. In June 1992 his CD4 count was 50 x 1000/ul. H
Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura in patients with HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:214 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291805; Harangozo CS; Marshall C; Slavin M; Fairfield Hospital, Victoria.; Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) have recently been described in association with HIV infection. We report 2 cases of HUS and 1 case of TTP associated with HIV. All 3 patients had advanced HIV disease with CD4 counts of 30 or less. 2 patients displayed the classical triad o
Disseminated thrombosis in HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:215 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291806; Kelly M; Lloyd A; Jones P; Brighton T; Dept. Infectious Diseases, POW/PHH, Sydney.; Thrombosis is rare in HIV infection. We report the case of a 57 year old male with transfusion acquired HIV infection who died of disseminated thromboembolic disease associated with undiagnosed Non-Hogkins Lymphoma (NHL) and antiphospholipid antibodies. His CD4 cell count was 500/ul (30%). The patient spontaneously de
Human immunodeficiency virus-1 induces increased activity of cellular topoisomerases.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:217 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291807; Jardine D; Tachedjian G; Locarnini S; Birch C; Antiviral Laboratory, Victorian Infectious Diseases Reference; Laboratory, Fairfield Hospital.; The presence of HIV supercoiled DNA in cells infected with this virus suggests a role for topoisomerases in the replication cycle of HIV-1. Previously we have demonstrated topoisomerase I activity in sucrose gradient purified HIV-1 virions from several isolates. By comparing the ionic requirements and inhibition by va
Transcriptional control of NFKB1 expression.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:218 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291808; Lambert P; Ludford M; Deacon N; Doherty R; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; Optimal expression from the HIV LTR is dependent on binding of proteins of the NF-kappa B/Rel family to their cognate motif in the HIV core enhancer. NF-kappa B/Rel proteins are transcription factors whose translocation from the cytoplasm to the nucleus is induced by cellular activating agents such as phorbol esters,
A novel Sp-1 site in the HIV-1 LTR.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:219 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291809; Peeters A; Deacon N; AIDS Molecular Biology Lab, NCHVR, Macfarlane Burnet Centre for; Medical Research, Fairfield, Vic.; Transcription of HIV-1 is primarily regulated through the U3 region of the LTR. Immediately 5 from the transcriptional start site are three Sp-1 sites which are responsible for basal transcription and two NF-kB sites which are primarily responsible for activated transcription from the LTR. To investigate other protei
HIV-1 NEF associates with host cell proteins involved with cellular signalling and activation.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:220 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291810; Greenway A; Azad A; McPhee D; AIDS Cellular Biology Unit, National Centre for Medical Research,; Fairfield, Victoria, Australia.; HIV-1 Nef protein causes the loss of cell surface CD4 and IL-2 receptor (IL-2R) from PBMC and CD4+ T-cell lines. As both CD4 and the IL-2 R play critical roles in antigen-driven helper T-cell signalling and T-cell proliferation, respectively, the role of Nef in the vir
HIV neuropathology: consequences of direct infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:222 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291811; Gonzales M; Neuropathology Research Laboratory, Royal Melbourne Hospital,; Parkville, VIC.; The appearance of HIV-specific antibodies in CSF soon after seroconversion and the subsequent development of a range of neuropathological changes reflect HIV neurotropism. Lymphoma and a range of opportunistic infections are components of the spectrum of HIV-related CNS pathology but a slowly developing encephalopathy
Cellular aspects of the pathogenesis of AIDS dementia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:223 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291812; Pulliam L; University of California, San Francisco, USA.; Several mechanisms have been hypothesized for the dementia associated with AIDS. They include neurotoxicity from the virus itself (eg. gp120, tat) or neurotoxic factors/cytokines produced from macrophages infected with HIV (eg. quinolinic acid, TNF alpha, IL-6). Our laboratory has
Cytokine aspects of the neuropathogenesis of HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:224 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291813; Wesselingh SL; Glass J; McArthur J; Griffin J; Griffin DE; Department of Microbiology and Infectious Diseases, Flinders; University, Bedford Park, South Australia.; AIDS is associated with three major neurological syndromes: HIV-Associated Dementia, Vacuolar Myelopathy and Predominantly Sensory Neuropathy. The central role of cytokines in the pathogenesis of these HIV-associated neurological diseases is now beyond doubt. Initial studies of cerebrospinal fluid indicated clearly th
Recent advances in nucleoside therapy.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:228 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291814; Pinching AJ; Department of Immunology, Medical College of Saint Bartholomew's; Hospital, West Smithfield, London, UK.; This talk will focus primarily on the three best studied nucleoside analogues-zidovudine ( AZT ), didanosine (ddI) and zalcitabine ( ddC )-in symptomatic HIV disease and on AZT in asympto
Antiretroviral drugs acting late in the HIV replication cycle.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:230 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291815; Birch C; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital.; Most antiretroviral drugs available for treatment of HIV infection are targeted at the reverse transcriptase, an enzyme acting relatively early (pre-integration) in the HIV replication cycle. There is a need for drugs directed at other sites, and the HIV protease and Tat gene product are potential targets. Both provid
Mechanism of CD4 and IL-2 receptor down-regulation by NEF.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:239 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291816; Allen KM; Greenway AL; McPhee DA; Aids Cellular Biology Unit, National Centre for Medical Research,; Fairfield, Victoria, Australia.; Human Immunodeficiency Virus (HIV) is a complex retrovirus that contains several structural proteins encoded by gag, pol and env, and at least seven auxiliary proteins derived from tat, nef, rev, vif, vpu, vpr and tev. The functions of several of these proteins have been clearly defined, whereas others such as the nef
NEF protein of HIV-1 is a positive regulator of virus replication.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:240 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291817; Arunagiri CK; Peden K; Sankovich S; McPhee D; Azad A; Biomolecular Research Institute, Parkville.; An investigation into the functions of Nef on HIV-1 replication was undertaken. Two molecular clones of HIV-1 viz.LAI and pNL 4.3 were selected and three mutant clones of nef were constructed. Nef mutants from LAI were constructed by frame shift mutation at amino acids 33 and 84 respectively and pNL 4.3 clone was cons
Estrogen response elements of the HIV LTR.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:241 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291818; Barnes N; Deacon N; Zeichner S; Doherty R; Macfarlane Burnet Centre for Medical Research, Fairfield.; We studied a putative estrogen response element (ERE) located in the 5 end of the HIV-1 LTR using a panel of 26 linker insertion mutant reporter plasmids. Transient transfections of MCF-7 cells grown in steroid-free medium were performed using DEAE-dextran Estrogen treated cells showed a 2-3 fold increase in CAT acti
Assessment of disease progression and T helper cell responsiveness to HIV peptides by quantitative RT-PCR of IL-2 & IL-2R mRNA.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:242 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291819; Biti R; Stewart G; Dept. Clinical Immunology, Westmead Hospital.; An important requirement for both the development and assessment of immune-based therapy is the accurate measurement of HIV-specific T cell immunity, with respect to T helper cell function. However, standard methodologies fail to address the difficulties associated with assessment of the immunocompromised individuals.
Effect of CD4(D2-D3)mutations on HIV entry.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:243 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291820; Blanc-Zouaoui D; Signoret N; Rocca-Serra J; Sattentau Q; Dpt of Microbiology, UQ, St Lucia, Brisbane.; CD4 is the first receptor for HIV on human cells, and the primary binding site has been mapped on domain 1, in the CDR2 region. Other domains of CD4 are thought to be important between the step of gp 120-CD4 binding and the fusion of gp 41 with a host cell membrane component. From a panel of anti-CD4 antibodies (abs),
Presence of HIV-1 neutralising antibodies in sera from a panel of asymptomatic individuals.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:244 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291821; Chatfield C; Learmont J; McPhee D; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.; Several patients received HIV-1 contaminated whole blood or red blood cells from a common donor between Jan. 1982 and June 1984. One of these recipients received a triple washed preparation and is HIV negative, another recipient died due to SLE. The six remaining recipients and the donor remain clinically free of symp
Development of a quantitative HIV-1 RNA PCR assay.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:245 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291822; Dowton DN; Dwyer DE; Cunningham AL; Department of Virology, ICPMR, Westmead Hospital.; The aim of this project is to develop an assay to quantitate the levels of circulating HIV-1 RNA in plasma of infected patients, and to apply this assay to antiretroviral drug trials and other clinical situations. Duplicates of plasma are spun by ultracentrifugation and lysed using a guanidium thiocyanate containing b
Quinolinic acid toxicity in human brain cultures.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:246 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291823; Kerr SJ; Armati PJ; Brew BJ; Centre for Immunology, St Vincent's Hospital, Darlinghurst NSW.; Quinolinic acid (QUIN) is a excitotoxic tryptophan metabolite, that largely acts at the N-methyl-D-aspartate (NMDA) receptor. It has been implicated in the pathogenesis of a wide range of inflammatory neurological disorders, including the AIDS dementia complex (ADC). Although QUIN
The induction of in vivo superinfection and recombination using feline immunodeficiency virus as the model.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:247 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291824; Kyaw-Tanner MT; Greene WK; Park HS; Robinson WF; Department of Veterinary Pathology, University of Queensland, St.; Lucia, Brisbane.; FIV is a lentivirus which shares many characteristics with HIV-1, and is considered appropriate for use as a model of HIV infection. We investigated the hypothesis that under certain conditions, in vivo superinfection of cats with FIV, may occur. One FIV isolate (T91) was used to inoculate three FIV and FeLV-free cats
The effect of GM-CSF on HIV-1 infection of monocyte-macrophages.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:248 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291825; Maerz A; Lopez A; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield, VIC.; AIM: Published data suggest that GM-CSF increases HIV replication in monocyte-derived cell lines (Ref.1) and primary monocyte-derived macrophages (2). The objective of this study was to further investigate the effects of GM-CSF on monocyte-derived-macrophages infected with HIV-1 in vitro. METHODS: Monocytes isolated b
Unexpectedly low levels of HIV specific CTL responses in peripheral blood of healthy asymptomatic HIV positive individuals.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:249 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291826; Marshall PD; Ffrench RA; Benson EM; Stewart GJ; Dept. of Immunology, Westmead Hospital, N.S.W.; A loss of HIV specific CTL activity has been reported to precede an accelerated rate of decline in CD4 count and as such, measuring CTL response could be used as an indicator of impending onset of end stage disease. However, contrary to previously published data we have found a lower HIV specific response and a lower
Molecular analysis of inhibition of HIV production by interleukin 10 in primary human monocytes derived macrophages.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:250 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291827; Naif H; Chang C; Ho-Shon M; Li S; Cunningham AL; Department of Virology, National Centre for HIV Virology; Research, Westmead, NSW.; Monocytes/macrophages play a major role in the pathogenesis of HIV infection particularly in the asymptomatic state of the disease. The mechanisms that regulate HIV expression during different disease stages are not well understood. Cytokines, as immune regulators, may contribute to the clinical latency and influence
Endocytosis and carriage of HIV-1 by human dendritic cells.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:251 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291828; Reece J; Vardaxis N; Crowe S; Cameron P; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; Blood dendritic cells (DCs) may play a critical role in the pathogenesis of HIV-1 infection by means other than their direct infection. CD4- blood DCs exposed to HIV-1, although uninfected, can efficiently transfer infection into CD4+ T cells, whereas cultured monocytes are less efficient. The ability of virus-pulsed
CD40L has potent antiviral activity.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:252 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291829; Ruby J; Ramshaw I; Viral Engineering Group, JCSMR, Canberra.; Signalling of B cells via the constitutively expressed CD40 molecule is an essential component of the T cell help required for an antibody response. The ligand for CD40 (CD40L or gp39) has been recently cloned and shown to be transiently induced on the surface of T cells as a consequence of antigen recognition. The in
CD4-bearing human thymic dendritic cells as targets for HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:253 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291830; Sotzik F; Shortman K; Lowe M; Coughlan A; Crowe S; Cameron P; Walter and Eliza Hall Institute of Medical Research, Royal; Melbourne Hospital, Parkville, Victoria.; We sought to isolate an early intrathymic precursor cell population from human thymus based on the phenotype of the equivalent cell in the mouse thymus, which expresses low levels of CD4 (Wu et al, Nature 349: 71). No clear cell population with the expected phenotype was found in human thymus. However a CD4+ human thy
Characterisation of p53 responsive regions in the HIV-1 LTR.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:254 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291831; Tanskanen E; Braithwaite A; Doherty R; Virus Interactions Laboratory, Macfarlane Burnet Centre for; Medical Research, Fairfield, Vic.; Transcriptional control over genes of HIV and other retroviruses is exerted by regulatory factors via responsive elements in the long terminal repeat (LTR). Functional p53 is a nuclear phosphoprotein which has a tumour suppressor role in dividing cells. p53 can act as a transcription factor, transactivating promoters
Assessment of the role of the costimulatory signal mediated via CD28 in HIV immunopathogenesis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:255 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291832; Williams LJ; Ffrench RA; Lee S; Stewart GJ; Department of Immunology, Westmead Hospital, N.S.W.; Activation of CD4+ T cells requires 2 signals, the first via interaction between the TCR/CD3 complex on CD4+ T cells and antigen/MHC class 2 complex on antigen presenting cells (APC). The 2nd signal is now believed to be transmitted by binding of CD28 on CD4+ T cells to molecules of the B7 family on APC. It is known t
Signal transduction by the cytokine receptor common gamma chain. Implications for HIV immunopathogenesis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:256 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291833; Williamson P; Gaulton G; Henthorn P; Department of Immunology, Westmead Hospital.; Recent cloning of the cytokine receptor common gamma chain (gamma c), and identification of its role in T-cell development and response, allows speculation that any perturbations of gamma c function caused by HIV would contribute greatly to CD4 cell dysfunction. Defects in gamma c function lead to signal transduction
Interleukin-2 receptor beta-chain signal transduction: implications for HIV immunopathogenesis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:257 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291834; Williamson P; Merida I; Gaulton G; Department of Immunology, Westmead Hospital.; Interleukin-2 ( IL-2 ) is a major growth and differentiation factor for T-cells, B-cells, NK-cells and monocytes. HIV infection is associated with abnormalities in IL-2 production and IL-2 responsiveness, which in turn are largely responsible for T-cell functional defect
A study of anti-retroviral therapy and Pneumocystis carinii (PCP) prophylaxis in 80 HIV positive patients with CD4 count less than 250 in a primary care setting.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:259 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291835; Bloch M; Duncombe C; Quan D; Holdsworth House General Practice, Darlinghurst, NSW.; STUDY OBJECTIVES: To determine anti-retroviral treatments and PCP prophylaxis in a group of HIV positive patients with CD4
Incidence and implications of oral hairy leukoplakia (OHL) and candidiasis in a cohort of people infected with human immunodeficiency virus (HIV) in South Australia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:260 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291836; Coates E; Slade G; Goss AN; Gorkic E; South Australian Dental Service, Adelaide.; OBJECTIVES: To ascertain the incidence of oral candidiasis and OHL in a cohort of HIV seropositive individuals in South Australia and determine possible significance in relation to HIV disease progression. METHODOLOGY: Data was collected from patients receiving care at the Adela
Ketoconazole shampoo in the treatment of seborrhoeic dermatitis in patients with HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:261 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291837; Duncombe C; Bloch M; Quan D; Holdsworth House General Practice, Darlinghurst NSW.; STUDY OBJECTIVES: To assess the safety and efficacy of Ketoconazole applied as a 2% shampoo in the treatment of seborrhoeic dermatitis in patients with concomitant HIV infection. METHODOLOGY: 46 HIV positive patients with moderate to severe facial and scalp seb. derm. applied Ketoconazole as a 2% shampoo to the scalp
Death from encephalitis within one week of proven HIV sero conversion illness onset.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:262 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291838; England JD; Liang T; Leicester J; Cunningham A; Lawrence C; Blue Mountains Hospital, Katoomba.; A 23 year old male previously known to be HIV negative three months prior developed an acute glandular fever like illness and raised liver enzymes. He was known to have a proven EB virus illness five years prior. His presenting symptom was painful pharyngitis and inability to tolerate oral antibiotics. Two days later
Comparison of the operational effectiveness of general practice versus hospital sites in a phase II HIV clinical trial.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:263 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291839; Hales G; Beveridge A; Anderson J; Mitchell J; Schreurs E; Smith D; CHATN, Darlinghurst.; OBJECTS: Data on Australian recruitment rates was examined to compare the operational effectiveness of General Practice sites versus hospital sites in an intensive phase II clinical trial. METHODS: The trial required 150 participants to attend trial sites at least monthly. The visits required clinical assessment, coll
The effect of the anabolic steroid, nandrolone decanoate, on lean body mass and quality of life in HIV+ men--a preliminary analysis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:264 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291840; Gold J; High H; Michelmore H; Oliver C; Albion Street Centre, Surry Hills, Sydney.; INTRODUCTION: Unexplained loss of lean body mass in HIV disease is common, particularly in the late stage, and contributes to reduced quality of life and survival time. This trend might be stabilised or reversed for a time with anabolic steroids and resitive exercise. METHOD: Patients who had lost 5-15% of their usual
Outpatient bactrim desensitisation.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:265 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291841; Kelly M; Lloyd A; Furner V; Dept. Infectious Diseases PHH, Sydney.; BACKGROUND: Bactrim is established as the drug of choice for Pneumocystis Carinii Pneumonia (P.C.P.) prophylaxis. More than 25% of HIV infected patients are unable to tolerate Bactrim because of hypersensitivity. Bactrim desensitisation in previously hypersensitive patients can be dangerous with deaths from anaphylaxi
Palliative care of AIDS: the last month of life.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:266 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291842; Malcolm JA; Dobson PM; Nineways Specialist Clinic, Broadmeadow NSW.; We reviewed clinical records of 50 men who died of AIDS in the Hunter Region, NSW, between 1988-1992. Mean age at death was 37 years (range 23-70). The most common principal cause of death was Cytomegalovirus infection (22%) with CMV retinitis in five cases. Oth
Infection with some co-pathogens influences HIV-related mortality.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:267 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291843; Mallon DF; Mallal SA; James IR; French MA; Dept of Clinical Immunology, Royal Perth Hospital, W. Australia.; OBJECTIVE: To describe the prevalence of prior infection with HBV, HCV, CMV , T. gondii and T. pallidum in a cohort of HIV-infected subjects at presentation and determine the influence of these infections on subsequent HIV-related mortality. DESIGN: Serum antibod
Pseudodeafness caused by speech latency delay in patients with the HIV associated dementia complex.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:268 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291844; Currie J; Malone V; Maruff P; Wright E; Hoy J; Brew B; Fairfield Infectious Diseases Hospital, Mental Health Research; Institute of Victoria.; OBJECTIVE: To examine the nature of a novel clinical syndrome of HIV related pseudodeafness, caused by delayed speech initiation (DSI) in patients with HIV associated dementia complex (HDC). METHODS: In a number of HIV+ patients referred for assessment of deafness, the actual defic
The d4T Australian Parallel Track program experience. Bristol-Myers Squibb d4T Parallel Track Program.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:269 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291845; Mijch A; Hoy J; Chuah J; Gold J; Spelman D; Fairfield Infectious Diseases Hospital.; Since November 1992, a new antiretroviral drug, stavudine ( d4T ), has been provided to eligible patients in USA and Canada and more recently in Australia and Europe through th
Spinal cord disease in AIDS patients in Melbourne.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:270 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291846; Pickles R; Fuller A; Spelman D; Department of Microbiology & Infectious Diseases, Alfred; Hospital, Prahran.; AIM: To describe the clinical details of six patients with lumbosacral polyradiculopathy in the setting of HIV-1 infection. CLINICAL FEATURES: Five patients had cytomegalovirus ( CMV ) polyradiculopathy diagnosed on the basis o
Neurological manifestations of HIV in an outpatient clinic including a case control study of factors associated with peripheral neuropathy.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:271 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291847; Woolley I; Faragher M; Spelman D; Fairfield Hospital, VIC.; BACKGROUND: The neurological manifestations of HIV are manifold and difficult to treat. Peripheral neuropathy in particular is a common disabling problem with no clear aetiology or entirely satisfactory treatment. AIM: 1. To describe the neurological manifestations of HIV/AIDS in an Australian context. 2. To ascertain
Hydrotherapy and HIV: a preliminary report.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:272 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291848; Zacka M; Boycott N; Perdices M; Kirkwood K; Painter L; Royal Prince Alfred Hospital, Camperdown NSW.; OBJECTIVES: Supervised exercise programmes for persons who are HIV+ have been shown, in some studies, to improve aerobic fitness and strength, and increase CD4 lymphocytes. Anecdotal evidence suggests that Hydrotherapy produces similar results. This study was designed to establish objectively the nature and extent of
Myocardial tuberculoma in a patient with AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:274 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291849; Cramp ME; Akhras F; Gazzard BG; Dept. of HIV Medicine, St. Vincents Hospital, Sydney.; Tuberculoma of the myocardium is extremely rare, occurring in less than 0.3% of patients dying from tuberculosis. Tuberculomas are seldom diagnosed ante-mortem and we report a case of myocardial tuberculoma presenting with cardiac tamponade in a patient with AIDS that resolved with anti-tuberculous chemotherapy.
Chlamydia trachomatis Fitz-Hugh Curtis syndrome. A cause of ruq pain in a man with HIV infection--case report.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:275 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291850; Fuller A; Spelman D; Spicer WJ; Johnson W; Garland S; Alfred Hospital, Prahran.; A 38 year old homosexual male infected with the Human Immunodeficiency Virus developed severe right upper quadrant pain in May 1993 necessitating admission to hospital. Examination revealed marked right upper quadrant tenderness. Ultrasound examination demonstrated marked tenderness over the liver but no gallstones we
Nonconvulsive generalised epilepsy and AIDS. A case report.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:276 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291851; Hale GE; Spelman D; Alfred Hospital, Melbourne.; A 40 year old HIV infected patient presented with hypomania. The patient was diagnosed HIV positive in 1989 and suffered his first AIDS defining illness in 1992 (oesophageal candidiasis). At the time of presentation, his CD4 count was 70. His medications included zidovudine and cotrimoxazole. He had been functioning a
Cryptococcal meningitis complicated by superior saggital sinus thrombosis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:277 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291852; Hale GE; Merrell WH; John Hunter Hospital, NSW.; A 27 year old patient presented with Cryptococcal Meningitis as an HIV presenting illness. There was a three month history of 10kg weight loss and recurrent chest infections. Three days prior to admission, the patient was noted to be intermittently drowsy and disorientated. On presentation, the patient was semicomatos
Cytomegalovirus causing appendicitis in an HIV positive patient.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:278 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291853; Hammett RJ; Edwards R; Kotsiou G; Pigott P; HIV Medicine Unit Royal North Shore Hospital, University of; Sydney, St. Leonards, N.S.W.; Cytomegalovirus ( CMV ) infection of the gastrointestinal tract is well described in patients with HIV infection, however CMV infection presenting as acute appendicitis has been described in only a few instances. We present a case of CMV appendicitis in an HIV pos
Longstanding psoriasis: a remission in a patient with AIDS and a falling T cell count.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:279 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291854; Hammett RJ; Edwards R; HIV Medicine Unit, Royal North Shore Hospital, University of; Sydney, St. Leonards N.S.W.; The development of psoriasis in patients with HIV/AIDS has been well described. In most reported cases there has been a deterioration in the patient s psoriasis with any decrease in CD4 count. Psoriasis in this setting is often resistant to conventional forms of therapy, although there have been reports of treatment s
Disseminated histoplasmosis acquired in Victoria in a patient with HIV: case report and review of literature.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:280 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291855; Kainer MA; Slavin M; Fairfield Hospital.; A 24 yr old homosexual man, HIV positive since 1992, presented in 1994 with a 6 week history of fevers, lethargy and weightloss of 20 kilograms. His CD 4 count was 30. Apart from a stay in Bangkok in 1975-6, aged 6 to 7 years, there was no other history of overseas travel. His only caving experience was a visit in Sep
Disseminated primary toxoplasmosis in HIV.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:281 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291856; Kelly M; Jones P; Clezy K; Lloyd A; Dept. Infectious Diseases, Prince Henry Hospital, Little Bay,; Sydney.; Toxoplasmosis usually manifests as a localised cerebral abscess in patients with profound immunodeficiency in HIV infection. We report a case of primary disseminated toxoplasmosis occurring in an HIV infected patient with moderate immunodeficiency. A 33 year old previously asymptomatic vegetarian homosexual HIV infect
Undiagnosed pulmonary infiltrates in HIV patients--what is the role of open lung biopsy?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:282 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291857; Marshall C; Street A; Royal Melbourne Hospital, Parkville.; OBJECTIVE: To describe an HIV positive patient with an unexplained pulmonary infiltrate who underwent an open lung biopsy and to review the role of open lung biopsy in HIV patients. METHODS: We provide a case description, a review of patients at The Royal Melbourne and Fairfield Hospitals who have undergone open lung
The AIDS library network N.S.W.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:284 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291858; Boon L; Mack N; Wylie J; Pannaci M; Rudd J; Albion Street Centre, Surry Hills.; AIM: To demonstrate how the networking/pooling of the resources of libraries which serve in the field of HIV/AIDS will enhance user access to the latest information available. EXPECTED OUTCOMES: Information access and delivery to users will become more effectual. Information dissemination will become more efficient. M
Prisoners' dilemmas--the roles of research in assessing and minimising the risks of blood borne communicable disease (BBCD) transmission among prisoners.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:285 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291859; Gaughwin M; Department of Community Medicine, University of Adelaide.; OBJECTIVE: To evaluate whether and how existing research strategies can be used to predict BBCD transmission among prisoners. METHODS: Research reviews, study designs and research questions from Australia in particular, have been examined to assess whether they can be used to pr
A contemporary evaluation of the risk of HIV transmission among prisoners in South Australia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:286 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291860; Seamark R; Gaughwin M; Department of Community Medicine University of Adelaide, North; Terrace, South Australia.; OBJECTIVES: To evaluate the risk of HIV transmission among SA prisoners. METHODOLOGY: Description of temporal trends in the prevalence of HIV among prisoners, 1989-1993. Description of the condition of injecting equipment found in prisons. Case control study of all known infected prisoners and a random sample of uninf
Pain in HIV/AIDS: a multidimensional approach.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:287 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291861; Glare P; Kirkwood K; Nicholas M; Royal Prince Alfred Hospital, Camperdown, N.S.W.; OBJECTIVES: (1) To assess the physical, psychological and social aspects of pain experienced by patients with HIV/AIDS using a range of well-validated self-report measures and a medical examination. (2) To prospectively evaluate the short-term outcome of current pain management practices in a sample of HIV/AIDS patien
Nutritional supplement use by HIV positive people in eastern area Sydney.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:288 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291862; Dangerfield F; High H; University of Sydney.; Generalised wasting and loss of lean body mass are common problems that affect the survival, quality of life and self image of HIV positive people. Nutritional supplements have been used successfully for weight gain and lean body mass repletion. Lactose free, fat modified supplements are used to decrease diarrhoea and
Patient-to-patient transmission of HIV in NSW--the public response.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:289 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291863; Tomkins M; Gold J; Harvey-Sutton P; Nelson M; Wu J; Albion Street Centre, Surry Hills, Sydney.; OBJECTIVES: To assess public reaction to the announcement in December 1993 of a case of patient to patient transmission of HIV in New South Wales by monitoring calls to the NSW HIV/AIDS Information Line. METHODS: Numbers of calls to the NSW HIV/AIDS Information Line after the announcement were compared to numbers of c
Women with HIV/AIDS--experiences with the medical profession in Victoria.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:290 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291864; Wilkinson J; This paper presents the results of a survey carried out on 40 women with HIV/AIDS by Positive Women (VIC). The survey asked women with HIV/AIDS to assess their care by the medical profession and the results identify areas in which positive women feel their needs are not being met.
The role of the medical profession in facilitating peer support.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:291 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291865; Wilkinson J; Peer support fulfils a vital role in contributing to the well-being of women with HIV/AIDS. This paper examines the role the medical profession plays in facilitating the access of peer support networks by positive women.
Epidemiological aspects of medically acquired HIV infection in Australia. National HIV Surveillance Committee.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:292 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291866; Ashton L; Kaldor J; National Centre in HIV Epidemiology & Clinical Research (NCHECR),; Darlinghurst, Sydney, NSW.; OBJECTIVE: To describe the epidemiology of medically acquired HIV infection (MAHIV) in Australia . METHODS: In 1990 the NCHECR established a National Registry of MAHIV. The goal of the registry was to provide accurate and complete information on the extent of MAHIV in Australia.
Ascertainment of exposure categories for HIV infected individuals with previously unreported data.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:294 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291867; Stevenson EM; Thompson SC; Crofts JN; Epidemiology Unit, Macfarlane Burnet Centre for Medical Research,; Fairfield, Vic.; OBJECTIVES: To identify exposure categories for individuals diagnosed with HIV in Victoria over the previous ten years for whom insufficient data had been recorded on HIV database, with the aim of identifying individuals whose exposure to HIV may have been through means other than those usually associated with HIV tra
The Kirketon Road Centre's needle and syringe exchange programme: a profile of injecting drug users.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:295 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291868; Dwyer R; van Beek I; Kaldor J; Kirketon Road Centre, Kings Cross.; Little Australian research on the characteristics of users of needle and syringe exchange programs (NSEP) has been reported. This paper reports on data collected at the Kirketon Road Centre NSEP over the 12 month period in 1992 to 1993. All new users of the KRC NSEP were required to register. They were provided with a
Survey of STDs, including HIV, amongst sex workers in northern Thailand.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:296 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291869; Gray J; Effler P; Supawitkul S; Kaldor J; National Centre for HIV Social Research, Macquarie University,; North Ryde, Sydney.; OBJECTIVES: To estimate prevalence and incidence of STDs, including HIV amongst sex workers in Thailand . METHODOLOGY: Data was obtained from an STD clinic attached to a district hospital in northern Thailand. Records were abstracted for every medical visit by every female sex wor
The diagnosis of HIV in the Northern Territory (NT) in the 90's--the tip of the iceberg?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:297 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291870; Knibbs PG; Bowden F; Mein J; AIDS/STD Unit, Royal Darwin Hospital, Tiwi NT.; STUDY OBJECTIVES--To determine the reasons for testing in HIV positive individuals first notified in the NT since 1990. METHODOLOGY--All HIV notifications for the NT for the period 1/1/90-25/7/94 were analysed. SUMMARY OF RESULTS--35 people have been diagnosed HIV+ in the study period. Of these only 11 (31.4%) request
A comparison of data obtained by patient interview with that obtained from pharmacy and medical records in patients with AIDS or HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:298 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291871; Law MG; Hurley SH; Carlin JB; Chondros P; Gardiner S; Kaldor JM; National Center in HIV Epidemiology and Clinical Research, NSW.; To assess the reliability of information reported by patients with AIDS or HIV infection, 123 homosexual men were recruited in Victoria, Australia , in 1992-1993 and interviewed to collect data retrospectively and prospectively on HIV related illness and treatment. These data wer
Survey of HIV seroprevalence and related risk behaviour at 3 Sydney needle exchanges.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:299 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291872; MacDonald M; Wodak A; van Beek I; Swift K; Taylor G; Cunningham P; Dolan K; Kelaher M; Moore T; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst, NSW.; OBJECTIVE: To describe the prevalence of HIV and related risk behaviour among IDU attending 3 needle exchange centres in Sydney and to assess the feasibility of carrying out routine surveillance in this setting. METHODS: Over a one week survey in February 1994, clients attending 3 needle exchange centres in Sydney wer
Pattern of diagnosis of AIDS defining illnesses, 1990-1993. National HIV Surveillance Committee.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:300 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291873; Ree H; McDonald A; AIDS Medical Unit, Brisbane.; OBJECTIVE: To describe the pattern of diagnosis of AIDS defining illnesses among cases of AIDS notified to the National AIDS Registry as having been diagnosed during the interval 1990 - 1993. METHODS: Cases of AIDS were notified to the National AIDS Registry through State and Territory health authorities. Information
Accessing zidovudine in Queensland.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:301 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291874; Murray J; Kennedy J; Zillmann J; Ree H; AIDS Medical Unit, Brisbane.; Patients with HIV are spread widely over Queensland. There is a perception that access to antiviral drugs is difficult owing to the geographical distribution. In this study, we examine the use of Zidovudine in Queensland, particularly in relation to (relatively) isolated areas of the state and examine the immunologica
Diversity in the face of adversity. The delivery of HIV/STD services in western New South Wales.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:303 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291875; Baldwin R; Dubbo Sexual Health and HIV Service, NSW.; The four Health Districts of Macquarie, Orana, Castlereagh and Far West serve an approximate total population of 150,000 and cover 43% of the state of New South Wales. Prior to 1993 these four districts were one--the Orana Far West Region. HIV/STD Services have been provided in varying degrees within these Districts s
Survival probability of vascular access devices in HIV infected patients.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:304 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291876; Boswarva P; St. Vincent's Hospital, Sydney Limited, Darlinghurst, NSW.; OBJECTIVES: To determine 1. the probability of vascular access devices (VAD) survival without removal due to infection and of incident free port usage at 3, 6 and 12 months; 2. any significant difference between the two survival probabilities. METHODOLOGY: A review of the medical records of HIV infected patients in wh
Goals for generalist community nurses caring for clients with H.I.V.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:305 (unnumbered poster). Unique Identifier : AIDSLINE ASHM6/95291877; Lucey A; Eastern Sydney Area Health Service, Royal South Sydney Hospital,; Zetland, NSW.; GOALS: maximise the general health of clients, minimise the risk of transmission of HIV and other diseases. ACTIONS: develop rapport with clients & caregivers, assess clients abilities and support network, maintain adequate infection control practices, support and liaise with members of the clients support network
Development of a complementary therapies resource kit.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:43 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291878; Jarvis C; Albion Street Centre, Surry Hills, NSW.; The Albion Street Centre is a multidisciplinary centre for HIV/AIDS clinical management, counselling, research, prevention and education. In keeping with the holistic focus of the Centre a need was seen to respect the choices of our clients who wished to embrace lifestyle changes and interventions such as many of the
Healthy HIV living program.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:44 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291879; Turbitt P; Community Health, Central Sydney, NSW.; This study s objective was to meet the expressed information and support needs of people with HIV Disease. A longitudinal descriptive study will be discussed of a Healthy HIV Living Program that developed as an attempt by a health service to meet expressed information and support needs that were not medicocentric an
Maintaining health: prophylaxis and zoonoses.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:45 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291880; Boswarva P; St. Vincent's Hospital Sydney Limited, Darlinghurst, NSW.; Many opportunistic infections manifesting as disease in the severely immunodeficient are reactivations of previous, dormant infection. Several forms of chemoprophylaxis have been shown to give a high level of protection against reactivation. In situations where opportunistic infections can occur de novo, simple lifest
HIV--defensive nutrition.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:46 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291881; Oliver C; Blackmores Ltd., Balgowlah, NSW.; There is increasing evidence that changes to nutritional status can occur in early HIV infection. Attention has been particularly on the role of micro-nutrients and body composition. The potential role of free radicals in viral replication is focusing attention on the body s anti-oxidant system and the nutrients that
Current perspectives in infection control and human immunodeficiency virus.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:47 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291882; Ibbotson V; Department of Microbiology, Royal North Shore Hospital, St.; Leonards, Australia.; The risk of health care worker to patient or patient to patient transmission of HIV is possible under certain conditions. There have been well publicised cases implying nosocomial transmission of HIV and Hepatitis C. This paper examines the case of the Florida dentist and the Eastern Sydney surgeon. The paper discusse
How well prepared are doctors and nurses to care for HIV/AIDS patients at district level in northeast Thailand?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:48 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291883; Ford B; Kingsbury AM; Abel M; Xeuatvongsa A; Chirawatkul A; Tropical Health Program, University of Queensland Medical School,; Herston.; While much emphasis has been placed on national HIV/AIDS programs, little has been written about programs at district or primary health care level. This study examines the implementation of national policies in one district of northeast Thailand . The knowledge, attitudes and prac
Tasmania--backward or beyond...? Mainstreaming HIV care in Tasmania.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:50 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291884; Roberts C; Sexual Health Service, Launceston, TAS.; In this paper a model of community based service delivery as influenced by the role of the Clinical Nurse Consultant HIV/AIDS which has been in use in Tasmania for the last 2 years will be explored. The main aims of the position were (1) to provide expert nursing consultancy within the community setting, (2) collabora
The role of the nurse practitioner at the Kirketon Road Centre.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:51 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291885; Martin C; Kirketon Road Centre, Kings Cross, NSW.; The Kirketon Road Centre (KRC) is a primary health care (PHC) facility of Sydney Hospital located in Kings Cross, involved in the prevention, treatment and care of HIV/AIDS and transmissible infections among at risk youth, sex workers and injecting drug users. Nurses have practised within a multi-disciplinary team at
Royal District Nursing Service HIV/AIDS program: changes for the future.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:52 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291886; Brown DM; HIV/AIDS Nursing Program, RDNS, Melbourne, North Caulfield, Vic.; Since 1986 the Royal District Nursing Service (RDNS), Melbourne, has been providing care to people with HIV/AIDS in the Melbourne Metropolitan area and Mornington Peninsula. The HIV/AIDS program consists of three Clinical Nurse Consultants (CNC), supported by a CNC reliever, an educator and liaison staff located in Me
Ostrich or eagle.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:53 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291887; May J; Philip Oakden House, Kings Meadows, Tasmania.; This paper will address the multiple issues which need to be considered and addressed when commissioning a new Hospice. It will take into account the important diverse issues such as: Gaining approval of admission criterias, which allows access to all members of society without prejudice to sex, age, religion, social,
In search of the geographical cure?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:54 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291888; Hawkins RM; SHAIDS, Lismore, NSW.; Since January 1991, 1900 people have accessed Sexual Health and AIDS Service (SHAIDS) in Lismore NSW for sexual health/HIV disease screening and or management. SHAIDS services an area containing one base hospital and ten smaller hospitals. This presentation will trace the development of a unique rural service and will
A personal insight into the role of a domiciliary HIV/AIDS clinical nurse consultant.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:57 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291889; Brown DM; HIV/AIDS Nursing Program, RDNS, Melbourne, North Caulfield, Vic.; Working as an HIV/AIDS Clinical Nurse Consultant (CNC) provides many experiences and challenges not well understood by those who do not work in the area. Many words describe this area of work; frustration, sadness, satisfaction, happiness and exhaustion, highlighting the importance of effective communication and good
Considerations when caring for someone with AIDS.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:58 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291890; Aberdour NS; Royal District Nursing Service, Altona North, Victoria.; Working in the area of HIV/AIDS nursing constantly reminds me of the tremendous range of physical, emotional, psychological, and social problems that people directly and indirectly affected by HIV/AIDS encounter on a daily basis. This paper attempts to look at two of the major issues faced. Not only from the patients
Nurses: a vital link to the health care system.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:59 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291891; Murray J; Zillmann J; Kennedy J; Ree H; AIDS Medical Unit, Brisbane.; Alice...went on. Would you tell me, please, which way I ought to go from here? That depends a good deal on where you want to get to, said the Cat. Lewis Carroll. Counselling has been defined as a range of interventions varying from providing information and outlining options through to brief psychotherapy. It has
Tasmania--backward of beyond...? Mainstreaming HIV care in southern Tasmania.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:60 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291892; Hodge K; Sexual Health Services, Hobart, TAS.; This paper will explore the Clinical Nurse Consultant s role in implementing a community based model to clients living with HIV/AIDS. This program has been running for 2 years and recently incorporating care of persons living with haemophilia. The main aim of the position was: 1) To improve the quality and quantity of
Nursing people with HIV/AIDS--a way of life.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:61 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291893; Kleemann M; Crock E; Fairfield Hospital, Northcote, Victoria.; OBJECTIVES: To identify ways in which the area of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) nursing differs from other areas of nursing; to make the experiences of nurses caring for people with HIV/AIDS (PWAs) visible, and thereby; to contribute to the development of nursing and to the
Patients' experience of nursing interventions during hospitalisation with their AIDS-defining illness.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:64 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291894; Kermode M; Fairfield Hospital, Victoria.; AIMS: The primary aim of this study was to explore patients experience and perceptions of helpful and unhelpful nursing interventions during hospitalisation with their AIDS-defining illness. The secondary aim was to develop understanding of the human experience of being diagnosed with AIDS. METHODOLOGY: Eight men rec
Survival probability of vascular access devices: HIV negative compared to HIV infected patients.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:65 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291895; Boswarva P; St. Vincent's Hospital Sydney Limited, Darlinghurst NSW.; OBJECTIVES: To determine the probability of vascular access devices (VAD) survival without removal due to infection and any significant difference between HIV+ve and HIV-ve patients and between Hickman catheters and ports. METHODOLOGY: A review of the medical records of patients in whom vascular access devices (VAD) h
Survey of the distribution and current management of wounds of clients with HIV/AIDS within a palliative care setting.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:66 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291896; Coughlan M; Spicer S; Dearden C; Cameron D; Sacred Heart Hospice, Darlinghurst N.S.W.; The Sacred Heart Hospice is a palliative care facility with 100 inpatient beds distributed over four wards. As part of a systematic approach to care, a baseline survey of the status and types of wounds experienced by clients with HIV/AIDS and the current management of those wounds was considered a priority. HIV/AIDS c
Clinical manifestations of human immunodeficiency virus (HIV-1) infection in Australian children infected during the neonatal period.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:67 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291897; Cruickshank M; Ziegler JB; Hughes C; Paediatric AIDS Unit, Prince of Wales Children's Hospital,; Randwick NSW.; AIM: To describe the clinical manifestations of human immunodeficiency virus (HIV-1) infection in Australian children infected during the neonatal period. METHOD: A retrospective review of children infected with HIV as neonates who were referred to the Paediatric AIDS Unit. RESULTS: 25 children were identified as infe
Ganciclovir administration practices in hospitals, ambulatory care settings, and in the home.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:68 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291898; Dobson PM; Groombridge C; MacDonald J; Dagg S; Immunology & Infectious Diseases Unit, John Hunter Hospital,; Hunter Region Mail Center, NSW.; Ganciclovir sodium (Cymevene) is an antiviral drug frequently used in the management of CMV infections which are a common cause of morbidity in patients with AIDS. Treatment in this group often consists of daily intravenous (IV) infusions of ganciclovir for prol
AIDS dementia complex: an overview.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:71 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291899; Brew BJ; St Vincent's Hospital, Darlinghurst, NSW.; AIDS dementia complex (ADC) is a predominantly subcortical dementia that occurs in approximately 20% of patients with advanced HIV disease. In a personally examined series, the mean CD4 count was found to be 94/1 +/- 38. The commonest symptoms were difficulty with concentration and
AIDS dementia: a complex of psychosocial issues.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:72 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291900; Pettett M; St Vincent's Hospital.; This presentation will highlight some of the major psychosocial issues arising from social work practice with AIDS dementia patients. Attention will be focussed on such areas as the emotional impact of ADC Diagnosis; impact on significant others; legal and treatment decision issues
Provision of AIDS dementia--care.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:73 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291901; Crawford D; St Vincent's Hospital HIV/AIDS Inpatients, Darlinghurst.; Aspects of the AIDS dementia complex (ADC) to be discussed in this presentation will focus on issues surrounding nursing ADC patients. Aspects to be covered from the nursing perspective will be managerial considerations, environmental planning, psychosocial impacts and controversie
HIV related brain disease: strategies and implications for service delivery--an overview of models of service provision in the UK.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:74 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291902; Casey KB; Albion Street Centre, Surry Hills, Sydney.; Community or welfare services are frequently unavailable to those without a formal AIDS Dementia Complex diagnosis (ADC). A number of strategies have been implemented to facilitate greater understanding of the psychosocial issues involved. A comprehensive research neuropsychological follow up register has been establi
Driving and the HIV associated dementia complex: the risk of motor vehicle accidents.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:75 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291903; Maruff P; Malone V; Tyler P; Wright E; Hoy J; Brew B; Currie J; Fairfield Infectious Diseases Hospital.; OBJECTIVE: To determine the risk of motor vehicle accidents among patients with HIV associated dementia complex (HDC) or HIV minor cognitive disorder (HMCD). METHODS: Patients were recruited through large metropolitan hospital impatient and outpatient departments. All patients comp
HIV/AIDS: learning from experience.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:78 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291904; Pinching AJ; Department of Immunology, Medical College of Saint Bartholomew's; Hospital, West Smithfield, London, UK.; We are at a turning point in our response to the pandemic of HIV and AIDS, passing from the steep learning curve of the early years to the slower phase of consolidation and more gradual progress. We have faced the rise in caseload, from the first, deeply instructive handful of patients to a truly horrifying scale of H
Confidentiality, privacy, and public health; is law a help or a hindrance?: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:79 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291905; Neave M; Monash University.; This paper discusses the legal issues raised by two recent cases; the first of which involved patient to patient transmission and the second of which involved an HIV-infected health care worker. The paper examines whether law can resolve the complex issues raised by these cases and the extent to which existing legal r
Combination antiretroviral chemotherapy: an interim analysis.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:82 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291906; Schooley RT; University of Colorado, Denver, USA.; Monotherapy with nucleoside analog reverse transcriptase inhibitors is associated with suppression of viral replication, an increase in CD4 cell counts, and, in most studies, a decrease in HIV-1 related morbidity and/or mortality. It is clear, however, that these benefits are limited in magnitude and duration. Several
The role of macrophages in the progression of HIV infection.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:83 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291907; Cunningham AL; Virology Department, University of Sydney, Westmead Hospital.; Macrophages in tissues and body fluids are a major cell target for HIV infection. HIV infected macrophages probably facilitate sexual and vertical transmission and contribute to the total body HIV load, especially as the infection is usually noncytopathic, mostly intracellular and less productive than with activated H
The effect of HIV on macrophage function.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:84 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291908; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield; Hospital, Vic.; Macrophages provide critical functions within the immune system, including chemotaxis, phagocytosis and killing of microbes, antigen presentation, cytokine production and tumour surveillance. The published literature does not consistently demonstrate abnormal function of cells of macrophage lineage following their inf
HIV and long-term survival.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:85 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291909; Levy JA; Cancer Research Institute, University of California, San; Francisco, USA.; HIV-1 and HIV-2, the causative agents of AIDS, consist of a wide variety of viral strains which differ in their biologic, serologic, and molecular properties. These viruses can be distinguished by the cells they infect, how well they replicate, whether they kill the cells infected, and how sensitive they are to antibo
Towards the ideal clinical trial: a participant's perspective.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:87 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291910; Duffin R; AIDS Council of NSW.; People with HIV have faced the task of trying to make meaning of clinical trials, what they mean and understanding quite complex decisions they face. The enthusiasm for participating in trials has changed. There is now less expectation of rapid advances in HIV medicine. More people have experienced clinical trials and
The ideal clinical trial: a clinician's perspective.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:88 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291911; Pinching AJ; Department of Immunology, Medical College of Saint Bartholomew's; Hospital, West Smithfield, London, UK.; Therapy is always provisional, based on the patient s clinical state and on currently available evidence regarding potential interventions from clinical trial and other data. Acknowledging the continuing areas of uncertainty is important for patient choice in electing to initiate or continue a therapeutic intervention
Judicial developments in The Netherlands regarding medical practices which shorten life.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:90 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291912; Remmelink MJ; Groningen University, Netherlands.; As in all civil states (see also the international treaties on human rights), the protection of life is ranked highly in Dutch legislation. Thus, murder can be punishable by a life sentence in prison. If a person acts on the request of another or facilitates a suicide, he is still punishable; however, a lower penalty
The Dutch Voluntary Euthanasia Society supporting HIV/AIDS patients.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:91 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291913; Cornelisse M; NVVE, Amsterdam, Netherlands.; The history and the goals of the Dutch Voluntary Euthanasia Society (NVVE) are described, as well as the different ways the NVVE tries to reach these goals: social acceptation and legalization of euthanasia and physician assisted suicide. Special attention is given to the work of the Members Aid Service (MAS), consist
Some reflections on euthanasia.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:92 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291914; Tobin B; John Plunkett Centre for Ethics in Health Care, St Vincent's; Hospital, Darlinghurst, NSW.; In this presentation I will start with a sketch of the subject matter of ethics. I will then distinguish euthanasia from a number of practices with which it is often confused. I will comment on the difference that (1) motive and (2) intention make to an act. I will comment on the argument in favour of legalising eutha
The Australian Study of HIV and Injecting Drug Use (ASHIDU): research in progress.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:95 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291915; Loxley W; Carruthers S; Wodak A; Crofts N; Dolan K; Gaughwin M; Kaldor J; National Centre for Research into the Prevention of Drug Abuse,; Perth, Western Australia.; ASHIDU, a multi-centre CARG study, is a cross-sectional survey which aims to provide data to facilitate the maximum achievable reduction of HIV transmission among and from injecting drug users in Australia . Nine hundred current injecting drug users, from treatment and non-treatm
Research and intervention amongst injecting drug users in the hills of northern Thailand.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:96 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291916; Gray J; National Centre for HIV Social Research, Macquarie University,; Sydney.; OBJECTIVES: To establish needle exchange programs and research injecting drug behaviours amongst the Akha Hilltribe. METHODOLOGY: A survey was carried out amongst the habitual drug users in three Akha villages in the far north of Thailand to ascertain the extent of drug use, the
Research into injecting drug use through needle exchanges.: Annu Conf Australas Soc HIV Med. 1994 Nov 3-6;6:97 (unnumbered abstract). Unique Identifier : AIDSLINE ASHM6/95291917; Wodak A; Macdonald M; Crofts N; Dolan K; Ali R; Loxley W; Alcohol and Drug Service, St Vincent's Hospital, Darlinghurst,; NSW.; This study aims to develop an affordable, systematic technique to enable regular monitoring and surveillance of risk behaviour and sero-incidence and sero-prevalence of blood borne viral infections (HIV, hepatitis B and C) among injecting drug users (IDUs) attending needle and syringe exchange programmes (NSEPs) in al
New information gathering study for KS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Review. 1995 Jan;(no 16):2. Unique Identifier : AIDSLINE AIDS/95700308; New studies are being launched to learn more about Kaposi s sarcoma (KS), a skin cancer common in AIDS patients that may be caused by a sexually-transmitted virus. A New York study is currently comparing skin biopsies from KS lesions, both from AIDS patients and those not infected with HIV, and is evaluating urine sam
Specificity of viral DNA integration in vitro and in vivo.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session I, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920001; Coffin J; Withers-Ward E; Barnes J; Kitamura Y; Tufts University School of Medicine. Department of Molecular; Biology and Microbiology, Boston, MA; To understand the role of DNA sequence and structure in targeting integration to specific sites or regions of the genome, we have developed a highly sensitive PCR-based assay capable of detecting with single-base resolution, a single molecule of proviral DNA into the cellular genome in 10-6 cells. Using this assay we
A human homologue of the yeast snf5 transcription factor binds and stimulates the hiv-1 integrase: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session I, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920002; Goff SP; Kalpana GV; Howard Hughes Medical Institute, Dept of Biochemistry and; Molecular Biophysics, Columbia University College of P & S, New; York, NY; We have used the yeast two-hybrid system to identify a novel human gene product that binds tightly to the HIV-1 integrase in vitro. The sequence of the gene suggests that the novel protein is a human homologue of yeast SNF5, a transcriptional activator required for high level expression of many genes. The mammalian pr
HIV preintegration complexes: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session I, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920003; Miller MD; Wang B; Bushman FD; In cells freshly infected by HIV, the viral cDNA can be found complexed with viral proteins in an integration- competent complex. We have been purifying such complexes and studying their composition and function. We have confirmed previous work in determining that the complexes are very high molecular weight and conta
Genetic footprinting: using a retroviral integrase to study gene function.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session I, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920004; Brown PO; Singh I; Crowley R; Department of Biochemistry, Stanford University; HHMI; As an approach to characterising the early steps in retroviral infection and discovering the roles viral proteins play in those steps, we would like to screen a large set of mutations in the viral genome for specific defects in this phase of the life cycle. Because the mutants of interest are expected to be rare, and
NIH Conference Retroviral Integrase.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session II, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920005; Skalka AM; The general outline of the integration pathway has been known for some time. DNA is synthesized within a subviral particle that is deposited in the cytoplasm of the infected cell after entry and uncoating of the virion. The first biochemical step, an endonucleolytic processing by which IN removes two nucleotides from
Processing of modified DNA substrates by HIV-1 integrase.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session II, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920006; Mazumder A; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Insitutite,; NIH, Bethesda, MD; The extents of strand transfer and 3 -processing via hydrolysis, alcoholysis, and circular nucleotide formation were examined using backbone-modified substrates. These substrates had a negatively charged phosphodiester linkage replaced by a neutral, hydrophobic methylphosphonodiester at various positions near the cons
Coordinated disintegration reactions of M-MuLV integrase.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session II, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920007; Roth MJ; Donzella GA; UMDNJ-RWJ Medical School, Dept of Biochemistry, Piscataway, NJ; A coordinated disintegration assay (crossbone disintegration) was utilized to investigate the possible protein-DNA and protein-protein interactions that are important for IN function. The substrate is an oligonucleotide which resembles a viral LTR joined to a partial target DNA site. Coordination of two oligonucleotid
Efficient concerted integration of retrovirus-like dna by integrase from avian myeloblastosis virus and hiv-1.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session I, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920008; Grandgenett D; Vora A; McCord M; Goodarzi G; Im G; Brackmann K; St Louis University, St. Louis, MO; We report the efficient concerted integration of a linear virus-like DNA donor into 2.8 Kbp circular DNA target by integrase (IN) purified from avian myeloblastosis virus (AMV) (Nucleic Acid Res. 22, 4454-4461, 1994). The donor was 487 bp (M-2), contained recessed 3 OH ends, was 5 end labeled, and had a unique restr
Analysis of in vitro hiv-1 dna integration reaction by uv cross-linking: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session II, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920009; Fujiwara T; Yoshinaga T; Shionogi Institute for Medical Science, Shionogi & Co, Ltd.; The DNA sequence requirements for the retroviral DNA integration reaction suggest the existence of a sequence- specific binding of integrase (IN) with substrate DNA. We detected three photoadduct bands applying UV cross-linking method to an integration reaction mixture consisted of recombinant HIV-IN and oligonucleoti
In vitro activities of hiv-1 integrase/e. coli lexa fusion proteins.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session II, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920010; Chow SA; Goulaouic H; Department of Molecular and Medical Pharmacology, UCLA School of; Medicine, Los Angeles, CA; One salient feature of retroviral integration is that many sites on the host DNA can be used as targets. The integration process, however, is not entirely random since there is a wide variation in integration frequency among individual target sites. The mechanism for selecting DNA sites for integration is not fully un
Improving the Solubility Properties of HIV-1 Integrase: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920011; Craigie R; Jenkins TM; Hickman AB; Ghirlando R; Laboratory of Molecular Biology, National Institute of Diabetes; and Digestive and Kidney Diseases, NIH, Bethesda, MD; Structural studies of retroviral integrase proteins have been obstructed by the poor solubility of these proteins. Our previous attempts to overcome this problem with HIV-1 integrase, including extensive trials of different solvent conditions and construction of deletion derivatives, have met with only limited success
Three Dimensional Structure of the Core Domain of HIV-1 Integrase: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920012; Dyda F; Hickman AB; Jenkins TM; Engelman A; Craigie A; Davies DR; Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD; The crystal structure of the core domain of HIV-1 integrase (residues 50 to 212), which is fully active for disintegration, will be described at 2.5 resolution. The structure reveals topological similarity to other polynucleotidyl transferases like (RNase H), Mu Transposase and the Holliday junction resolvase RuvC. T
Triplex-mediated inhibition of hiv dna integration in vitro: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920013; Auclair C; Mouscadet J; Carteau S; Goulaouic H; Subra F; Laboratoire de Physicochimie et de Pharmacologie des; Macromolecules Biologiques, Institut Gustave-Roussy, Villejuif,; France.; Integration of HIV DNA into the genome of host cells is an obligatory step in the replicative cycle of the virus. The overall process is carried out in vitro by a single viral protein, the integrase (IN), which binds to short sequences located at the ends of viral DNA long terminal repeats (LTRs). These end sequences
The future possibilities and current realities of soluble low molecular weight synthetic combinatorial libraries: a revolution in basic research and drug discovery: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920014; Houghten RA; Appel J; Blondelle S; Dooley C; Eichler J; Pinilla C; Houghten Pharmaceuticals, Torrey Pines Institute for Molecular; Studies; The technology of soluble synthetic combinatorial libraries (SCLs) and synthetic peptide combinatorial libraries (SPCLs) [Nature 354:84-85, 1991], which are made up of tens of millions of different compounds, is revolutionizing the drug discovery process. Recent developments permit the screening of billions of compoun
The integrase proteins of HIV-1 and HIV-2: potential targets for anti-HIV drugs: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920015; Plasterk RHA; Vink C; Puras-Lutzke R; van den Ent F; van der Linden K; The Netherlands Cancer Institute, Amsterdam (RPLAS@ron.nki.nl); The mechanism of HIV DNA integration has been studied in vitro, using integrase protein purified from recombinant E. coli, and synthetic oligonucleotide substrates. Recent studies focus on structure/function analysis of integrase, using mutant derivatives of the protein. In parallel with these mechanistic studies we h
High-throughput screening for hiv-1 integrase inhibitors: one YEAR AFTER.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920016; Mayaux JF; Huet T; Pernelle C; Becquart J; Gueguen JC; Tahraoui L; Evers M; Henin Y; Bousseau A; Dereu N; Rhone-Poulenc Rorer, Vitry-Alfortville Research Center, Vitry Sur; Seine Cedex, France.; Although HIV-1 integrase obviously represents a very attractive pharmacological target for the treatment of HIV infection, specific and potent integrase inhibitors have not yet been described. In order to find such molecules, recombinant HIV-1 integrase was first purified from E. coli and fully characterized. A high t
HIV-1 integrase inhibitors: discovery, structure-activity, inhibition mechanisms, selectivity.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920017; Pommier Y; Mazumder A; Kohn KW; Laboratory of Molecular Pharmacology, National Cancer Institute,; NIH, Bethesda, MD; Several assays can be used to identify HIV-1 integrase inhibitors. We are using recombinant HIV-1 integrase and radiolabeled oligonucleotides to study various reactions of HIV-1 integrase: DNA binding, 3 -processing, strand transfer, and disintegration. The disintegration reaction offers the advantage of being catalyz
The use of immobilized substrates to identify and characterize inhibitors of hiv-1 integrase: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Session III, speakers' abstracts - unpaged). Unique Identifier : AIDSLINE AIDS/95920018; Hazuda D; Felock P; Hastings J; Uncapher C; Wolfe A; Department of Antiviral Research, Merck & Co., West Point, PA; In the life cycle of HIV-1, a crucial step in replication is the integration of a DNA copy of the viral genome into the genome of the host cell. The process of integration requires a series of endonucleolytic and DNA strand transfer steps which are catalyzed by a virally encoded protein, integrase. An assay for the DN
Small Hydroxylated Aromatic Inhibitors of HIV-1 Integrase as Potential Anti-AIDS Drugs: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 1). Unique Identifier : AIDSLINE AIDS/95920019; Burke Jr TR; Fesen M; Driscoll J; Yung J; Kohn K; Pommier Y; Laboratory of Medicinal Chemistry, Developmental Therapeutics; Program, DCT, NCI, NIH; Bldg. 37, Rm 5C06; Bethesda, MD; A number of HIV integrase inhibitors have been identified using the cell-free assay originally developed by Craigie et al. based on the two step base deletion/transesterification mechanism of the enzyme. Many of these inhibitors contain ployhydroxylated aromatic rings, with several also having secondary degrees of uns
Efficiency of hiv-1 integration in cultured human cells: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 1a). Unique Identifier : AIDSLINE AIDS/95920020; Dimitrov DS; Englund G; Martin MA; National Cancer Institute, Bethesda, MD; We have developed a PCR-based approach, which, in combination with a video imaging system, allowed the accurate quantitation of viral DNA synthesis following infection of T lymphocytes with HIV-1 U5 deletion mutants. The kinetics of viral DNA accumulation in infected cells was measured for the wild type HIV-1 NL4-3, a
Real time assay for the hiv-1 integrase 3'-processing reaction using a novel fluorescent guanosine analog.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 2). Unique Identifier : AIDSLINE AIDS/95920021; Hawkins ME; Pfleiderer W; Balis FM; Pediatric Branch, National Cancer Institute, Bethesda, MD; Fluorescence is an important tool for studying protein/DNA interactions because fluorophores are sensitive to changes in their molecular environment and reflect those changes through measurable differences in fluorescence. Unfortunately, most fluorophores are large molecules and, when linked to DNA, their presence can
Improving the Solubility Properties of HIV-1 Integrase: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 3). Unique Identifier : AIDSLINE AIDS/95920022; Craigie R; Jenkins TM; Hickman AB; Ghirlando R; Laboratory of Molecular Biology, National Institute of Diabetes; and Digestive and Kidney Diseases, NIH, Bethesda, MD; Structural studies of retroviral integrase proteins have been obstructed by the poor solubility properties of these proteins. Our previous attempts to overcome this problem with HIV-1 integrase, including extensive trials of different solvent conditions and construction of deletion derivatives, have met with only limi
Functional analysis of chimeras between hiv-1 and visna virus integrase enzymes.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 4). Unique Identifier : AIDSLINE AIDS/95920023; Katzman M; Sudol M; Department of Medicine, Department of Microbiology and; Immunology, The Pennsylvania State University College of; Medicine, Hershey, PA; Three regions of HIV IN have been defined: the N-terminus (amino acid residues 1-49) contains a conserved zinc finger motif and is required for optimal enzymatic activity, the central region (residues 50-186) has a highly conserved D,D(35)E motif, and the non-conserved C-terminus (residues 187-288), which also is requ
Characterization of mg2+ - dependent endonucleolytic activity and development of a fluorescence assay for hiv-1 integrase in vitro.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 5). Unique Identifier : AIDSLINE AIDS/95920024; Lee SP; Kim HG; Censullo ML; Knutson JR; Han MK; Georgetown University Medical Center, Department of Biochemistry,; Washington, DC; In vitro reactions of Human Immunodeficiency Virus-1 Integrase (HIV-IN) performed with short oligonucleotide substrates show a preference for Mn2+ as the catalytic cofactor. In contrast, studies with infected cell extracts show that viral DNA integration occurs in the presence of Mg2+. We report that changes in the st
A peptide inhibitor of hiv-1 integrase from a combinatorial library.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 5a). Unique Identifier : AIDSLINE AIDS/95920025; Lutzke RAP; Eppens NA; Weber P; Plasterk RHA; Houghten RA; The Netherlands Cancer Institute, Amsterdam; The HIV integrase (IN) protein is potentially a good target for antiviral strategies, because retroviral DNA integration is essential for HIV replication and IN is required for integration of viral cDNA. Traditionally, drug lead compounds are derived from natural origins. For the source of potential drugs one relies o
The localization of catalytic activities in Tn7 transposition: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 6). Unique Identifier : AIDSLINE AIDS/95920026; May E; Sarnovsky R; Craig N; Department of MB & G, Johns Hopkins School of Medicine; We study the bacterial transposable element Tn7. Tn7 moves using a cut and paste mechanism which on the molecular level is similar to the movement of retroviruses. The Tn7 transposition machinery generates a pair of staggered breaks at the ends of the element, creating 3 recessed ends. These 3 ends, which terminate
Integration of incomplete hiv-1 reverse transcription products.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 6a). Unique Identifier : AIDSLINE AIDS/95920027; Miller MD; Wang B; Bushman FD; Infectious Disease Laboratory, The Salk Institute for Biological; Studies, La Jolla, CA; Despite intensive study, the mechanism by which many retroviruses complete reverse transcription has remained unclear. Many retroviruses and all lentiviruses fail to complete the synthesis of the second strand of the viral cDNA (plus strand) efficiently in infected cells. For HIV- 1, we find in single step infection e
Oligonucleotide Binding Properties of the HIV-1 Integrase - A Potential to wrap single stranded DNA?: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 7). Unique Identifier : AIDSLINE AIDS/95920028; Pemberton I; Buckle M; Buc H; Unite de Physicochemie des Macromolecules Biologique, Institut; Pasteur, Paris; HIV-1 IN performs the catalytic functions required for the integration of a linear DNA molecule provided that authentic viral LTR sequences are present at both DNA termini. Apparently anomolously, however, in vitro the HIV-1 IN binds to non-viral DNA substrates with an affinity comparable to that observed for sequence
Expression of the human integrase interacting protein (ini1) prevents growth of a yeast mutant, rad52, defective in chromosome metabolism.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 8). Unique Identifier : AIDSLINE AIDS/95920029; Perkins E; Resnick MA; Laboratory of Molecular Genetics, National Institute of; Environmental Health Sciences, NIH, Research Triangle Park, NC; The human Ini1 protein was originally identified in a two- hybrid screen designed to isolate proteins that might interact with HIV integrase (1). Since such proteins may play a significant role in integrase function, they are potential targets for modifying integrase activity and possibly the progression of HIV infect
The integrase proteins of HIV-1 and HIV-2: potential targets for anti-HIV drugs.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 9). Unique Identifier : AIDSLINE AIDS/95920030; Plasterk RHA; Vink C; Puras-Lutzke R; van den Ent F; van der Linden K; The Netherlands Cancer Institute, Amsterdam; The mechanism of HIV DNA integration has been studied in vitro, using integrase protein purified from recombinant E. coli, and synthetic oligonucleotide substrates. Recent studies focus on structure/function analysis of integrase, using mutant derivatives of the protein. In parallel with these mechanistic studies we h
On the structural determinants of hiv integration into chromatin.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 10). Unique Identifier : AIDSLINE AIDS/95920031; Pruss FD; Bushman D; Wolffe AP; NICHD/NIH, Bethesda MD; Integration of the HIV DNA into the human chromosomes is a necessary step in the viral lifecycle. Nucleosomal DNA is known to be accepted and even preferred as the target by the viral integration machinery. We used purified HIV integrase, a synthetic LTR-like substrate and a number of nucleosomal and free DNA integrat
Molecular Dynamics Simulation of a Leucine Zipper Motif Predicted for the Integrase of Human Immunodeficiency Virus Type I.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 10a). Unique Identifier : AIDSLINE AIDS/95920032; Wang CY; Yang CF; Lai MC; Lee YH; Lee TL; Lin TH; National Tsing Hua University, Taiwan, R.O.C.; We have used the molecular dynamics (MD) simulation package AMBER4 to search the conformation of a peptide predicted as a leucine zipper motif for the human immunodeficiency virus type I integrase protein (HIV IN-LZM). The peptide is composed of 22 amino acid residues and its location is from Val 151 to Leu 172. The s
Finding new inhibitors of the hiv-1 integrase: structure: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 11). Unique Identifier : AIDSLINE AIDS/95920033; Weinstein JN; Raghavan K; Buolamwini J; Zaharevitz D; Paull KD; Mazumder A; Fesen M; Kohn KW; Pommier Y; Lab of Molecular Pharmacology and Information Technology Branch,; Developmental Therapeutics Program, DCT, NCI, Bethesda, Md.; The aim of this study was to identify new compounds active against the HIV-1 integrase using as a guide the hypothesis (Fesen, et al., Biochem. Pharmacol., in press) that ortho-OH groups favor inhibition (of both the cleavage and integration steps). Fesen, et al. (PNAS 90:2399, 1993) have identified inhibitors of this
Expression of unintegrated hiv-1 dna.: NIH Conf Retroviral Integrase. 1995 Jan 19-20;:(Participants' abstracts and posters, abstract no. 12). Unique Identifier : AIDSLINE AIDS/95920034; Wiskershen MA; Muesing MA; Division of Infectious Disease, Lilly Research Laboratories,; Indianapolis, IN; Integrated proviral DNA maintained within host chromosomal DNA is an active template for the expression of retroviral gene products. Although circular forms of viral DNA can be found after retroviral infection in the nucleus of the infected host cells, these viral DNAs are generally believed to be transcriptionally si
[Extrapulmonary mycobacterial infection with multiple cold abscesses]: Ann Pathol. 1995;15(2):127-30. Unique Identifier : AIDSLINE MED/95275341; Paumier V; Caulet S; Leguerrier A; Turlin B; Jouannic I; Pavin D; Darnault P; Ramee MP; Service d'Anatomie et Cytologie Pathologiques B, C.H.R.U; Pontchaillou, Rennes.; We report one case of extrapulmonary mycobacterial infection, in the absence of HIV infection, singular by a clinical presentation simulating a tumor, associating a bulky intrahepatic mass, an abscess of the psoas, multiple intracerebral lesions, and an obstructive intracardiac mass of the right ventricle, which requi
[Rhinosinusitis in AIDS patients]: Laryngorhinootologie. 1995 Mar;74(3):188-90. Unique Identifier : AIDSLINE MED/95275399; Wurzer H; Heppt W; Weidauer H; Rosen-Wolff A; Hartmann M; HNO-Klinik Med. Hochschule Hannover.; We examined microbic infections and topical immunity in 36 AIDS patients with rhinosinusitis (AIDS CDC stage IV b-d) who had an average serum CD4 count of 90/microliters. We also examined the presence of the HIV genome in nasal mucous. Microbiological examination revealed an increased number of fungal infections in ad
Scientific and public health rationale for HIV vaccine efficacy trials. World Health Organization.: AIDS. 1995 Mar;9(3):WH01-4. Unique Identifier : AIDSLINE MED/95275453
Pathogenesis of hypersensitivity reactions to drugs in patients with HIV infection: allergic or toxic? [editorial]: AIDS. 1995 Mar;9(3):217-22. Unique Identifier : AIDSLINE MED/95275454; Koopmans PP; van der Ven AJ; Vree TB; van der Meer JW
Immunization with class I human histocompatibility leukocyte antigen can protect macaques against challenge infection with SIVmac-32H.: AIDS. 1995 Mar;9(3):223-8. Unique Identifier : AIDSLINE MED/95275455; Chan WL; Rodgers A; Grief C; Almond N; Ellis S; Flanagan B; Silvera P; Bootman J; Stott J; Kent K; et al; National Institute for Biological Standards and Control, South; Mimms, Potters Bar, UK.; OBJECTIVE: To evaluate the efficacy of immunopurified class I human histocompatibility leukocyte antigen (HLA) to protect against SIV infection. METHODS: HLA class I antigens were immunopurified from a human B-lymphoblastoid cell line. Groups of four macaques were vaccinated subcutaneously with four doses of the immun
Impaired Fc alpha receptor expression is linked to increased immunoglobulin A levels and disease progression in HIV-1-infected patients.: AIDS. 1995 Mar;9(3):229-34. Unique Identifier : AIDSLINE MED/95275456; Grossetete B; Viard JP; Lehuen A; Bach JF; Monteiro RC; INSERM Unit 25, Necker Hospital, Paris, France.; OBJECTIVES: Expression of immunoglobulin (Ig) A Fc receptors (Fc alpha R) and their saturation by endogenous IgA were studied on blood monocytes and neutrophils to evaluate the role of Fc alpha R in the formation of increased serum levels of IgA and IgA-immune complexes (IgA-IC) observed during HIV-1 infection. METHOD
Protection of neonatal kittens against feline immunodeficiency virus infection with passive maternal antiviral antibodies.: AIDS. 1995 Mar;9(3):235-42. Unique Identifier : AIDSLINE MED/95275457; Pu R; Okada S; Little ER; Xu B; Stoffs WV; Yamamoto JK; Department of Comparative and Experimental Pathology, College of; Veterinary Medicine, University of Florida, Gainesville 32610,; USA.; OBJECTIVE: Maternal antibodies from either vaccinated or feline immunodeficiency virus (FIV)-infected female cats (queens) were evaluated for their ability to protect kittens against homologous FIV infection. DESIGN: Kittens that received different levels of maternal antiviral antibodies from either vaccinated or infe
Safety and immunogenicity of a V3 loop synthetic peptide conjugated to purified protein derivative in HIV-seronegative volunteers.: AIDS. 1995 Mar;9(3):243-51. Unique Identifier : AIDSLINE MED/95275458; Rubinstein A; Goldstein H; Pettoello-Mantovani M; Mizrachi Y; Bloom BR; Furer E; Althaus B; Que JU; Hasler T; Cryz SJ; Albert Einstein College of Medicine, Bronx, New York 10461, USA.; OBJECTIVES: To develop a peptide-based model for a preventive vaccine for HIV-1 infection. DESIGN: Phase I trial in HIV-1-seronegative volunteers. PARTICIPANTS: Adult healthy subjects HIV-1-antibody-seronegative in an enzyme-linked immunosorbent assay, screened for tuberculin [purified protein derivative (PPD)] reacti
A prospective evaluation of clinical criteria and polymerase chain reaction assay of cerebrospinal fluid for the diagnosis of cytomegalovirus-related neurological diseases during AIDS.: AIDS. 1995 Mar;9(3):253-60. Unique Identifier : AIDSLINE MED/95275459; Gozlan J; el Amrani M; Baudrimont M; Costagliola D; Salord JM; Duvivier C; Picard O; Meyohas MC; Jacomet C; Schneider-Fauveau V; et al; Department of Bacteriology, Saint-Antoine Hospital, Paris,; France.; OBJECTIVE: To study the predictive value of clinical criteria and polymerase chain reaction (PCR) assay of cerebrospinal fluid (CSF) for the diagnosis of cytomegalovirus ( CMV )-related neurological disorders during AIDS. SETTI
Impact of clarithromycin and azithromycin on patterns of treatment and survival among AIDS patients with disseminated Mycobacterium avium complex.: AIDS. 1995 Mar;9(3):261-6. Unique Identifier : AIDSLINE MED/95275460; Ives DV; Davis RB; Currier JS; Division of Infectious Diseases, Beth Israel Hospital, Boston, MA; 02215, USA.; OBJECTIVE: To determine the impact of the introduction of clarithromycin and azithromycin on the treatment and survival of patients with AIDS and disseminated Mycobacterium avium complex (DMAC). DESIGN: Retrospective review over a 3.5-year interval. SETTING: Tertiary-care, university teaching hospital. PATIENTS: Chart
Preventive chemotherapy for HIV-associated tuberculosis in Uganda: an operational assessment at a voluntary counselling and testing centre.: AIDS. 1995 Mar;9(3):267-73. Unique Identifier : AIDSLINE MED/95275461; Aisu T; Raviglione MC; van Praag E; Eriki P; Narain JP; Barugahare L; Tembo G; McFarland D; Engwau FA; Ministry of Health, Entebbe, Uganda.; OBJECTIVE: To assess the operational aspects of isoniazid preventive chemotherapy (IPT) for tuberculosis in persons dually infected with HIV and Mycobacterium tuberculosis identified at an independent HIV voluntary counselling and testing centre in Kampala, Uganda . DESIGN: HIV-infe
Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings. Multicenter Hemophilia Cohort and Hemophilia Growth and Development Studies.: AIDS. 1995 Mar;9(3):275-80. Unique Identifier : AIDSLINE MED/95275462; Kroner BL; Goedert JJ; Blattner WA; Wilson SE; Carrington MN; Mann DL; Epidemiologic and Medical Studies Program, Research Triangle; Institute, Rockville, MD 20852, USA.; OBJECTIVE: To assess the association between human leukocyte antigen (HLA) haplotypes and the incidence rates of CD4 decline to
Income and AIDS rates in Los Angeles County.: AIDS. 1995 Mar;9(3):281-4. Unique Identifier : AIDSLINE MED/95275463; Simon PA; Hu DJ; Diaz T; Kerndt PR; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; OBJECTIVE: To examine the relationship between income and AIDS rates in Los Angeles County (LAC) by race/ethnicity. METHODS: 1990 US census data were used to classify LAC postal zones (zip codes) by median household income into low-, middle-, and high-income strata. AIDS rates were calculated for each income stratum b
Sexual behaviour and risk of exposure to HIV among 18-25-year-olds in Scotland: assessing change 1988-1993.: AIDS. 1995 Mar;9(3):285-92. Unique Identifier : AIDSLINE MED/95275464; Robertson BJ; Research Unit in Health and Behavioural Change, University of; Edinburgh, UK.; OBJECTIVE: To study changes in sexual behaviour related to HIV transmission in young people between 1988 and 1993. DESIGN: Data collected by computer-assisted telephone interview with 4081 individuals aged 18-25 years resident in central Scotland. The data were collected on a monthly basis between 1988 and 1993 and ag
Traditional vaginal agents: use and association with HIV infection in Malawian women.: AIDS. 1995 Mar;9(3):293-7. Unique Identifier : AIDSLINE MED/95275465; Dallabetta GA; Miotti PG; Chiphangwi JD; Liomba G; Canner JK; Saah AJ; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland, USA.; OBJECTIVES: To assess the prevalence of traditional vaginal agent use in Malawian women and its association with HIV infection. METHODS: Consenting, consecutive antenatal women were administered a questionnaire and screened for sexually transmitted diseases (STD) including HIV. RESULTS: Of the 6603 consenting women, 8
Trimethoprim-sulphamethoxazole desensitization in HIV-infected patients: an open study [letter]: AIDS. 1995 Mar;9(3):299-300. Unique Identifier : AIDSLINE MED/95275466; Bachmeyer C; Salmon D; Guerin C; Barre C; Hazebroucq G; Sicard D; Sereni D
Cryptococcal disease in HIV infection: treatment and maintenance [letter; comment]: AIDS. 1995 Mar;9(3):300-1. Unique Identifier : AIDSLINE MED/95275467; Fisher M; Price DA; Klein J; Weston R; Coker RJ
Oral yeast colonization of HIV-infected outpatients [letter]: AIDS. 1995 Mar;9(3):301-2. Unique Identifier : AIDSLINE MED/95275468; McNeil J; Kan V
Does the choice of Pneumocystis carinii prophylaxis influence the prevalence of Enterocytozoon bieneusi microsporidiosis in AIDS patients? [letter]: AIDS. 1995 Mar;9(3):302-3. Unique Identifier : AIDSLINE MED/95275469; Albrecht H; Sobottka I; Stellbrink HJ; Greten H
Spontaneous pneumomediastinum in AIDS [letter]: AIDS. 1995 Mar;9(3):304-5. Unique Identifier : AIDSLINE MED/95275470; Delvecchio G; Tambini R; Fracassetti O; Lorenzi N; Cremaschi A; Gavazzeni G
Treatment of AIDS-associated lymphoma with interferon-alpha and intravenous gammaglobulin [letter]: AIDS. 1995 Mar;9(3):305-6. Unique Identifier : AIDSLINE MED/95275471; Bergmann OJ; Madsen M; Kristensen JS; Andersen PL; Black FT
High HIV risk among gay Asian and Pacific Islander men in San Francisco [letter]: AIDS. 1995 Mar;9(3):306-8. Unique Identifier : AIDSLINE MED/95275472; Choi KH; Coates TJ; Catania JA; Lew S; Chow P
Infection of macaques after vaginal exposure to a primary isolate of SIVmac251 [letter]: AIDS. 1995 Mar;9(3):308-9. Unique Identifier : AIDSLINE MED/95275473; Le Grand R; Nadal M; Cheret A; Roques P; Vaslin B; Matheux F; Theodoro F; Gras G; Gauthier L; Aubertin AM; et al
The potential of nonoxynol-9 for the prevention of HIV infection reconsidered [letter] [see comments]: AIDS. 1995 Mar;9(3):310-1. Unique Identifier : AIDSLINE MED/95275474; Wittkowski KM
Nonoxynol-9: the need for policy in the face of uncertainty [letter; comment]: AIDS. 1995 Mar;9(3):311-2. Unique Identifier : AIDSLINE MED/95275475; Elias C; Heise LL
Bone remodelling in human immunodeficiency virus-1-infected patients. A histomorphometric study.: Bone. 1995 Feb;16(2):185-91. Unique Identifier : AIDSLINE MED/95275596; Serrano S; Marinoso ML; Soriano JC; Rubies-Prat J; Aubia J; Coll J; Bosch J; Del Rio L; Vila J; Goday A; et al; Department of Pathology, Hospital del Mar, Universitat Autonoma; de Barcelona, Spain.; The aim of this study was to identify and describe possible alterations of bone histomorphometry in patients with human immunodeficiency virus (HIV-1) infection and to assess the relation between these alterations and disease severity. Forty-four HIV-1-infected patients seen successively at our hospital were evaluated
Bacillary angiomatosis with cutaneous and oral lesions in an HIV-infected patient from the U.K.: Br J Dermatol. 1995 Jan;132(1):113-5. Unique Identifier : AIDSLINE MED/95275673; Levell NJ; Bewley AP; Chopra S; Churchill D; French P; Miller R; Gilkes JJ; Department of Dermatology, University College London Medical; School, U.K.; We describe an HIV positive patient with histologically confirmed cutaneous and oral lesions of bacillary angiomatosis , an unusual clinical presentation. As far as we are aware, this is the first reported case of cutaneous bacillary angiomatosis in the U.K.
Considerations about the prophylactic role of T cell vaccination in HIV infection.: Rev Roum Virol. 1994 Jan-Jun;45(1-2):47-54. Unique Identifier : AIDSLINE MED/95275723; Ruta SM; Alexandrescu R; Antipa C; Tirdei G; Popescu A; Cernescu C; Stefan S. Nicolau Institute of Virology, Bucharest, Romania.; The AIDS epidemic in Romania has properties that are both common to countries of Eastern Europe and unique to Romania. The unique aspects include the large number of cases in children infected parenterally and a relatively low but steadily increasing number of HIV infected adults.
[Human herpesvirus 6. General overview]: Rev Roum Virol. 1994 Jan-Jun;45(1-2):83-95. Unique Identifier : AIDSLINE MED/95275726; Tirdei G; Ruta SM; Popescu AE; Institut de Virologie, Stefan S. Nicolau, Bucarest, Roumanie.; Human herpesvirus 6 (HHV6) was first isolated in 1985 and included in the Herpesviridae family and the beta-herpes virinae subfamily, mainly due to its genomic similarities to the human cytomegalic virus (HCMV). HHV6 is largely disseminated in the population. The contamination takes place very early, most frequently b
Sexual beliefs, attitudes and knowledge of adolescent youths in Ibadan concerning AIDS.: West Afr J Med. 1994 Oct-Dec;13(4):245-7. Unique Identifier : AIDSLINE MED/95275754; Asuzu MC; Department of Preventive and Social Medicine, University College; Hospital, Ibadan.; This is a descriptive cross-sectional study of Ibadan secondary school students who took part in an open and voluntary family life education programme in 1990. Of the 306 estimated youth attendants of at least 1 day of the 4-day programme, 266 filled the registration form and questionnaire well enough to be used in th
Identification of nucleotide binding sites in the poliovirus RNA polymerase.: Biochemistry. 1995 May 16;34(19):6288-95. Unique Identifier : AIDSLINE MED/95275819; Richards OC; Hanson JL; Schultz S; Ehrenfeld E; Department of Molecular Biology and Biochemistry, University of; California, Irvine 92717, USA.; Poliovirus RNA polymerase (3Dpol) was cross-linked to [32P]ribonucleoside triphosphates (NTPs) by reduction of oxidized NTP-protein complexes. Cross-linked complexes were digested with cyanogen bromide, and resulting peptides were fractionated by reverse-phase HPLC. 32P-Labeled peptides were purified by secondary HPLC
Major groove opening at the HIV-1 Tat binding site of TAR RNA evidenced by a rhodium probe.: Biochemistry. 1995 May 16;34(19):6303-9. Unique Identifier : AIDSLINE MED/95275821; Neenhold HR; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical; School-UMDNJ, Piscataway, USA.; Transactivation of human immunodeficiency virus (HIV) gene expression requires the interaction of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5 -end of all mRNAs. The TAR RNA contains a six-nucleotide loop and a three-nucleotide pyrimidine bulge which
Interdomain communication of T-cell CD4 studied by absorbance and fluorescence difference spectroscopy measurements of urea-induced unfolding.: Biochemistry. 1995 May 16;34(19):6464-74. Unique Identifier : AIDSLINE MED/95275842; Tendian SW; Myszka DG; Sweet RW; Chaiken IM; Brouillette CG; Southern Research Institute, Birmingham, Alabama 35205, USA.; CD4 is a transmembrane glycoprotein expressed on T-lymphocytes. It is a receptor for class II major histocompatibility complex (MHC) molecules and for the HIV envelope glycoprotein gp120. The extracellular portion of CD4 (sCD4) is a rod-shaped molecule consisting of four domains designated D1 through D4. Denaturant-in
Characterization of the internal motions of Escherichia coli ribonuclease HI by a combination of 15N-NMR relaxation analysis and molecular dynamics simulation: examination of dynamic models.: Biochemistry. 1995 May 23;34(20):6587-601. Unique Identifier : AIDSLINE MED/95275855; Yamasaki K; Saito M; Oobatake M; Kanaya S; Protein Engineering Research Institute, Osaka, Japan.; The backbone dynamics of Escherichia coli ribonuclease HI (RNase HI) in the picosecond to nanosecond time scale were characterized by a combination of measurements of 15N-NMR relaxation (T1, T2, and NOE), analyzed by a model-free approach, and molecular dynamics (MD) simulation in water. The MD simulations in water we
Solution structure of a homopyrimidine: homopurine dodecamer encoded by the HIV-1 envelope gene: NMR and molecular simulation studies.: Biochemistry. 1995 May 23;34(20):6900-10. Unique Identifier : AIDSLINE MED/95275890; Sodano P; Hartmann B; Rose T; Wain-Hobson S; Delepierre M; Laboratoire de Resonance Magnetique Nucleaire, CNRS URA 1129,; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.; The solution structure of the nonpalindromic dodecanucleotide homopyrimidine:homopurine, d(5 -TTTCTCCTTTCT):d(5 -AGAAAGGAGAAA), was determined by two-dimensional nuclear magnetic resonance spectroscopy combined with molecular simulation. The dodecamer sequence studied was found within the HIV-1 envelope sequence and h
The cell membrane of Mycoplasma penetrans: lipid composition and phospholipase A1 activity.: Biochim Biophys Acta. 1995 May 4;1235(2):369-77. Unique Identifier : AIDSLINE MED/95275916; Salman M; Rottem S; Department of Membrane and Ultrastructure Research, Hebrew; University-Hadassah Medical School, Jerusalem, Israel.; Analysis of Mycoplasma penetrans membrane lipids revealed that, in addition to large amounts of unesterified cholesterol, M. penetrans incorporated exogenous phospholipids, preferentially sphingomyelin, from the growth medium. The major phospholipids synthesized de novo by M. penetrans were phosphatidylglycerol (PG) a
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1995 Mar;20(3):531-41. Unique Identifier : AIDSLINE MED/95276052; Opravil M; Hirschel B; Lazzarin A; Heald A; Pechere M; Ruttimann S; Iten A; von Overbeck J; Oertle D; Praz G; et al; University Hospital of Zurich, Switzerland.; To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of
Disseminated Mycobacterium scrofulaceum infection: a potentially treatable complication of AIDS.: Clin Infect Dis. 1995 Mar;20(3):549. Unique Identifier : AIDSLINE MED/95276054; Sanders JW; Walsh AD; Snider RL; Sahn EE; Department of Medicine, Medical University of South Carolina,; Charleston 29425, USA.; Disseminated Mycobacterium scrofulaceum infection has rarely been reported (only 8 cases to date), and no case of infection associated with AIDS has been reported in detail. We report a case of disseminated M. scrofulaceum infection in an AIDS patient that presented as chronic ulcerative and nodular skin lesions with
Multifocal cellulitis and monoarticular arthritis as manifestations of Helicobacter cinaedi bacteremia.: Clin Infect Dis. 1995 Mar;20(3):564-70. Unique Identifier : AIDSLINE MED/95276056; Burman WJ; Cohn DL; Reves RR; Wilson ML; Medical Laboratories, Denver Department of Health and Hospitals,; Colorado 80204, USA.; Helicobacter cinaedi (formerly Campylobacter cinaedi) was first detected in the fecal flora of homosexual men. Since 1984, 11 case reports of H. cinaedi bacteremia have been published; most cases have presented as a nonspecific febrile illness in homosexual men infected with the human immunodeficiency virus (HIV). We
Aspergillus fungemia: report of two cases and review.: Clin Infect Dis. 1995 Mar;20(3):598-605. Unique Identifier : AIDSLINE MED/95276062; Duthie R; Denning DW; Department of Microbiology, University of Manchester, Hope; Hospital, Salford, United Kingdom.; We present two cases of aspergillus infection confirmed by blood culture and review 30 other cases of genuine aspergillus fungemia and 34 cases of aspergillus pseudofungemia. Multiple different media and blood culture systems were used to isolated Aspergillus. The median time to positive blood culture was 8.5 days (ra
Value of liver biopsy for the rapid diagnosis of infection in human immunodeficiency virus-infected patients who have unexplained fever and elevated serum levels of alkaline phosphatase or gamma-glutamyl transferase.: Clin Infect Dis. 1995 Mar;20(3):606-10. Unique Identifier : AIDSLINE MED/95276063; Cavicchi M; Pialoux G; Carnot F; Offredo C; Romana C; Deslandes P; Dupont B; Berthelot P; Pol S; Unite d'Hepatologie, Hopital Necker, Paris, France.; We prospectively determined the value of liver biopsy for microbiological diagnosis of infection in patients infected with the human immunodeficiency virus (HIV) who had unexplained fever and whose serum levels of alkaline phosphatase or gamma-glutamyl transferase were at least 1.5 times the upper limit of normal. Fro
Cryptococcal disease of the CNS in immunocompetent hosts: influence of cryptococcal variety on clinical manifestations and outcome.: Clin Infect Dis. 1995 Mar;20(3):611-6. Unique Identifier : AIDSLINE MED/95276064; Mitchell DH; Sorrell TC; Allworth AM; Heath CH; McGregor AR; Papanaoum K; Richards MJ; Gottlieb T; Westmead Hospital, New South Wales, Australia.; We performed a retrospective review of cases of cerebral cryptococcosis among patients admitted to 12 Australian teaching hospitals between 1985 and 1992. Of 118 cases identified, 35 occurred in immunocompetent hosts. When cases due to Cryptococcus neoformans variety neoformans were compared with those due to Cryptoco
DNA subtypes and fluconazole susceptibilities of Candida albicans isolates from the oral cavities of patients with AIDS.: Clin Infect Dis. 1995 Mar;20(3):634-40. Unique Identifier : AIDSLINE MED/95276068; Barchiesi F; Hollis RJ; McGough DA; Scalise G; Rinaldi MG; Pfaller MA; Department of Pathology, University of Texas Health Science; Center, San Antonio 78284-7750, USA.; Sixty-two Candida albicans isolates from the oral cavities of 28 patients with AIDS who were receiving fluconazole therapy were typed by restriction endonuclease analysis followed by pulsed-field gel electrophoresis; these isolates were then tested for fluconazole susceptibility by a standard broth dilution method. Se
Utility of the gallium-67 citrate scan for the early diagnosis of tuberculosis in patients infected with the human immunodeficiency virus.: Clin Infect Dis. 1995 Mar;20(3):652-6. Unique Identifier : AIDSLINE MED/95276071; Santin M; Podzamczer D; Ricart I; Mascaro J; Ramon JM; Dominguez A; Rufi G; Gudiol F; Infectious Disease Service, Ciutat Sawnitaria i Universitaria; de Bellvitge, Barcelona, Spain.; Diagnosis of tuberculosis in patients infected with the human immunodeficiency virus (HIV) is sometimes difficult because of atypical clinical and radiographic findings. The aim of this retrospective study was to determine the utility of a gallium-67 citrate scan (67Ga scan) of the chest for the early diagnosis of tub
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.: Clin Infect Dis. 1995 Mar;20(3):696-9. Unique Identifier : AIDSLINE MED/95276078; Araujo AQ; Andrada-Serpa MJ; Paulo-Filho TA; Rodrigues MT; Prado LA; HTLV-Associated Neuropathy Unit, Evandro Chagas Hospital,; Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil.; Human T-cell lymphotropic virus type I (HTLV-I) can be associated with either adult T-cell leukemia or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic progressive immune-mediated myelopathy. Skin manifestations such as xerosis and erythema may be associated with HAM/TSP. Infective dermat
Mass lesions of the larynx due to cytomegalovirus infection in a patient infected with the human immunodeficiency virus [letter]: Clin Infect Dis. 1995 Mar;20(3):726-7. Unique Identifier : AIDSLINE MED/95276093; Tinelli M; Castelnuovo P; Panigazzi A; D'Andrea F; Caprioglio S
Administration of pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients with AIDS [letter]: Clin Infect Dis. 1995 Mar;20(3):730-1. Unique Identifier : AIDSLINE MED/95276095; Bessesen MT; Miller LA; Cohn DL; Bartlett S; Ellison RT 3d
Mandatory screening of pregnant women for human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1995 Mar;20(3):732. Unique Identifier : AIDSLINE MED/95276097; Stahl AJ; Smith RM; Schaening O; Lutwick LI
A peripheral blood-derived monolayer supports long-term cultures of human CD4+ and CD8+ T lymphocytes.: Blood. 1995 Jun 1;85(11):3213-22. Unique Identifier : AIDSLINE MED/95276255; Sutkowski N; Kuo ML; Amenta PS; Dougherty JP; Ron Y; Department of Molecular Genetics and Microbiology, University of; Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical; School, Piscataway 08854, USA.; An in vitro culture system has been developed for the long-term maintenance of primary, human peripheral blood and umbilical cord blood T lymphocytes, which does not rely on the use of stimulatory cytokines, antigen, or mitogens. In these cultures, a monolayer of adherent cells, some spindle-shaped and some resembling
Defective CD4+ T-lymphocyte reconstitution in major histocompatibility complex class II-deficient transplant models [letter]: Blood. 1995 Jun 1;85(11):3354-6. Unique Identifier : AIDSLINE MED/95276276; Huss R; Nepom GT; Deeg HJ
A cell culture system for study of the development of Toxoplasma gondii bradyzoites.: J Eukaryot Microbiol. 1995 Mar-Apr;42(2):150-7. Unique Identifier : AIDSLINE MED/95276720; Weiss LM; Laplace D; Takvorian PM; Tanowitz HB; Cali A; Wittner M; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York 10461, USA.; Toxoplasma gondii is a ubiquitous apicomplexan parasite and a major opportunistic pathogen under AIDS-induced conditions, where it causes encephalitis when the bradyzoite (cyst) stage is reactivated. A bradyzoite-specific Mab, 74.1.8, reacting with a 28 kDa antigen, was used to study bradyzoite development in vitro by
Epidemiology of AIDS and tuberculosis.: Bull Pan Am Health Organ. 1995 Mar;29(1):37-58. Unique Identifier : AIDSLINE MED/95276787; Garcia Garcia ML; Valdespino Gomez JL; Garcia Sancho MC; Salcedo Alvarez RA; Zacarias F; Sepulveda Amor J; National Institute of Epidemiologic Diagnosis and Reference; (Instituto Nacional de Diagnostico y Referencia; Epidemiologicos), Mexico City, Mexico.; This article reviews literature on the epidemiology, pathogenicity, and control of HIV and Mycobacterium tuberculosis coinfection. Regarding pathogenicity, immune system deterioration makes HIV-infected people more likely to develop active tuberculosis on primary or secondary exposure to the bacillus or to suffer reac
[Familial AIDS: a revealing case study]: Infirm Que. 1995 May-Jun;2(5):10-1. Unique Identifier : AIDSLINE MED/95276821; Levesque H
Cell specific uptake of antiretroviral drugs: AZT coupled to LDL inhibits HIV replication in human macrophages.: Int J Clin Pharmacol Ther. 1995 Feb;33(2):85-8. Unique Identifier : AIDSLINE MED/95276987; Mankertz J; von Baeyer H; Rokos K; Nundel M; Pauli G; Riedel E; Freie Universitat Berlin, Institut fur Biochemie, Germany.; Macrophages, besides helper T-lymphocytes, are target cells for the human immunodeficiency virus (HIV). We report on a mechanism to deliver selectively antiretroviral drugs to cells of the monocyte/macrophage lineage. These cells and cells of the endothelium express scavenger receptors which mediate the transport of m
Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture.: Brain Res. 1995 Feb 27;673(1):141-8. Unique Identifier : AIDSLINE MED/95277152; Holliday J; Parsons K; Curry J; Lee SY; Gruol DL; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, CA 92037, USA.; In humans, elevated levels of cytokines are associated with several diseases (including HIV infection and Down Syndrome) that result in developmental abnormalities. Overexpression of interleukin-6 (IL-6) in the central nervous system has been shown to cause extensive neuronal abnormality in mice that becomes more evid
[Pneumocystis-carinii thyroiditis]: Ryoikibetsu Shokogun Shirizu. 1993;(1):328-31. Unique Identifier : AIDSLINE MED/95277316; Mitsuma T; Fourth Department of Internal Medicine, Aichi Medical University.
Gene therapy for treating HIV infection may be an option [letter; comment]: Am J Health Syst Pharm. 1995 Feb 15;52(4):423. Unique Identifier : AIDSLINE MED/95277593; Green L; Minor JR
An overview of the oral manifestations of AIDS-related Kaposi's sarcoma.: Compendium. 1995 Feb;16(2):136-8, 140, 142 passim; quiz 148. Unique Identifier : AIDSLINE MED/95277773; Flaitz CM; Nichols CM; Hicks MJ; Division of Oral Pathology, University of Texas Health Science; Center, Dental Branch, Houston, USA.; Acquired immunodeficiency syndrome-associated Kaposi s sarcoma (AIDS-KS) is the most common malignancy in human immunodeficiency virus infection and is seen most often in homosexual men. The oral cavity is frequently involved by AIDS-KS and may represent the initial site of this malignancy in up to 60% of patients. A
Expression of the CR1 receptor on human leukemia-derived CD4+ T cell lines.: Cell Immunol. 1995 Jun;163(1):139-47. Unique Identifier : AIDSLINE MED/95277858; Yaskanin DD; Waxman FJ; Department of Microbiology and Immunology, University of Oklahoma; Health Sciences Center, Oklahoma City 73190, USA.; The complement receptor type 1 (CR1) is a membrane glycoprotein expressed on a variety of cells including some, but not all, human T lymphocytes. The present study was designed to investigate CR1 expression on human leukemia-derived CD4+ T cell lines. The expression of CR1, as well as the complement receptor type 2 (C
Effect of in vivo depletion of CD4+ and CD8+ cells on the induction and maintenance of oral tolerance.: Cell Immunol. 1995 Jun;163(1):19-29. Unique Identifier : AIDSLINE MED/95277861; Barone KS; Jain SL; Michael JG; Department of Molecular Genetics, Biochemistry and Microbiology,; University of Cincinnati, Ohio 45267-0524, USA.; The role of CD8+ and CD4+ cells in the generation and maintenance of high-dose oral tolerance has been investigated. Mice depleted of CD8+ cells prior to or subsequent to oral tolerization with OVA continued to express suppressed humoral and/or T cell proliferative responses to the homologous antigen. To assess the ef
A preliminary report on urinary BT-PABA/PAS excretion index, serum pancreatic isoamylase and faecal chymotrypsin tests of pancreatic dysfunction in Sowetan Africans.: Clin Chim Acta. 1995 Jan 16;233(1-2):89-99. Unique Identifier : AIDSLINE MED/95277953; Chaloner C; Segal I; Hassan H; McIntosh J; Gut A; Rahme M; Braganza JM; Department of Medicine (Gastroenterology), Royal Infirmary,; Manchester, UK.; The steady increase in chronic pancreatitis among black Africans at Soweto, RSA, in the past 40 years necessitates an objective and non-invasive test to detect the disease at an early stage. Given the biphasic nature of the disease--secretory hyperfunction with periodic active inflammatory episodes followed by steady
[Preliminary study of pneumocystis carinii pneumonia diagnosed by induced expectoration in HIV positive patients in Dakar]: Dakar Med. 1993;38(2):115-8. Unique Identifier : AIDSLINE MED/95278121; Sow PS; Diouf G; Diop BM; Mboup A; Wangre A; Marlink R; Ndir O; Coll-Seck AM; Service des Maladies Infectieuses, CHU Fann, Dakar.; Rapid noninvasive diagnosis of Pneumocystis carinii from induced liquefied sputum is a very easy and not costly method. It was using for a first time at the Infectious Diseases Department at Dakar in 27 HIV seropositive patients from July to November 1992. Six cases of Pneumocystis carinii pneumonia (PCP) was diagnose
[Esophagitis in Bamako. Apropos of 228 cases]: Dakar Med. 1993;38(2):153-7. Unique Identifier : AIDSLINE MED/95278128; Maiga MY; Traore HA; Toure F; Dembele M; Diallo AN; Pichard E; Service d'Hepato-Gastro-Enterologie, Hopital Gabriel, Toure.; Our main objective has been to study the prevalence of oesophagitis by upper digestive endoscopy. Within 12 months, we have registered 228 cases of oesophagitis out of 612 oesophagean anomalies (37.25%) during 3019 fibroscopies. Oesophagitis has been found to 63.59% in cases in young adult men. Peptic oesophagitis has
[Value of PCR in the diagnosis of tuberculosis in samples negative by direct examination in HIV+ and HIV patients]: Dakar Med. 1993;38(2):165-7. Unique Identifier : AIDSLINE MED/95278130; Niang-Ndiaye M; Camara T; Cissokho S; Hane AA; Launois P; Institut Pasteur, Dakar, Senegal.; A PCR system that amplify a repetitive fragment of the insertion sequence IS6110 specific for M. tuberculosis was compared to direct examination in samples from HIV+ and HIV-patients. 138 clinical samples (90 sputa, 30 blood and 18 urines) were analyzed in Senegal , a tuberculosis
[Use of an apoptosis test in the biological follow up of patients infected with HIV]: Dakar Med. 1993;38(2):181-2. Unique Identifier : AIDSLINE MED/95278133; Toure Balde A; Michel P; Faye M; Sarthou JL; Institut Pasteur, Dakar.; Among biological parameters, spontaneous apoptosis has been studied in lymphocyte culture of HIV seropositive patients. Apoptosis seems to be related with CD4+ deletion.
[Current advances in HIV pathogenesis. Results of therapy and vaccine development]: Dtsch Med Wochenschr. 1995 May 19;120(20):728-36. Unique Identifier : AIDSLINE MED/95278168; Wagner R; Mayer J; Wolf H; Institut fur medizinische Mikrobiologie, Universitat; Regensburg.
Prospective study of drug-resistant tuberculosis in a Spanish urban population including patients at risk for HIV infection.: Eur J Clin Microbiol Infect Dis. 1995 Feb;14(2):105-10. Unique Identifier : AIDSLINE MED/95278231; Ausina V; Riutort N; Vinado B; Manterola JM; Ruiz Manzano J; Rodrigo C; Matas L; Gimenez M; Tor J; Roca J; Microbiology Laboratory, Sta. Cruz and San Pablo Hospital,; Barcelona, Spain.; From January 1988 to October 1992, the primary resistance to first-line antituberculous drugs in 501 tuberculous patients was evaluated prospectively. Three-hundred and seventeen patients were HIV-negative and 184 were HIV-positive; these patients had several different clinical forms of tuberculosis. Moreover, the acq
Outbreak of Pneumocystis carinii pneumonia in a renal transplant unit.: Eur J Clin Microbiol Infect Dis. 1995 Feb;14(2):122-6. Unique Identifier : AIDSLINE MED/95278234; Hennequin C; Page B; Roux P; Legendre C; Kreis H; Service de Microbiologie, Hopital Necker-Enfants Malades, Paris,; France.; The charts for seven renal transplant recipients who developed Pneumocystis carinii pneumonia were reviewed. They included six men and one woman transplanted a mean of 150 days before the diagnosis of this infection. Six presented at least one episode of acute graft rejection. Cytomegalovirus pneumonia was diagnosed i
Bias of phenotypic techniques for identification of Campylobacter isolates [letter]: Eur J Clin Microbiol Infect Dis. 1995 Feb;14(2):153-5. Unique Identifier : AIDSLINE MED/95278245; Matsiota-Bernard P; Chevrier D; Nauciel C; Guesdor J
The impact of antiviral therapy with zidovudine: a retrospective study on HIV-positive hemophiliacs in Italy. Italian Group of Congenital Coagulopathies.: Haematologica. 1995 Jan-Feb;80(1):25-30. Unique Identifier : AIDSLINE MED/95278799; Arcieri R; Puopolo M; Baudo F; Chiarotti F; De Rosa V; Schinaia N; Mori PG; Ghirardini A; Laboratory of Epidemiology and Biostatistics, AIDS Center, Roma,; Italy.; BACKGROUND. The effects of zidovudine (ZDV) treatment on progression to AIDS are not completely clear. This study evaluated the effects of ZDV treatment on the progression to AIDS in HIV-positive hemophiliacs. METHODS. A retrospective study was carried out on HIV-infected hemophiliacs: it included 238 individuals, 119
AZT+methotrexate in high-grade HIV-related non-Hodgkin lymphomas: interim report on feasibility and tolerance.: Haematologica. 1995 Jan-Feb;80(1):31-4. Unique Identifier : AIDSLINE MED/95278800; Tosi P; Gherlinzoni F; Visani G; Coronado O; Chiodo F; Tura S; Istituto di Ematologia, L. e A. Seragnoli, University of; Bologna, Italy.; BACKGROUND. 3 azido-3 deoxythymidine ( AZT ) is a thymidine analogue useful in the treatment of AIDS. We have previously demonstrated that AZT can possess significant antineoplastic activity when combined with de novo thymidylate synthesis inhibitors,
[Epstein Barr virus lies in wait for immunosuppressed patients (news)]: Fortschr Med. 1995 Mar 20;113(8):12-3. Unique Identifier : AIDSLINE MED/95278850; Gurtler L
[Tuberculosis--still a problem? (editorial; comment)]: Fortschr Med. 1995 Mar 30;113(9):1. Unique Identifier : AIDSLINE MED/95278854; Magnussen H
[1995 status of tuberculosis (see comments)]: Fortschr Med. 1995 Mar 30;113(9):115-9. Unique Identifier : AIDSLINE MED/95278855; Schutt-Gerowitt H; Institut f. Med. Mikrobiologie und Hygiene der Univ., Koln.; While the number of active cases of tuberculosis in the USA and in some European countries has increased over the last few years, the incidence in Germany is (as yet) a relatively constant 17.5/100,000 (figure for 1993). For foreign citizens, however, the case rate was considerabl
The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2.: Genomics. 1995 Feb 10;25(3):749-52. Unique Identifier : AIDSLINE MED/95278952; Steinkasserer A; Jones T; Sheer D; Koettnitz K; Hauber J; Bevec D; Sandoz Research Institute, Vienna, Austria.; The eukaryotic initiation factor 5A (eIF-5A) has been identified as an essential cofactor for the HIV-1 transactivator protein Rev. Rev plays a key role in the complex regulation of HIV-1 gene expression and thereby in the generation of infectious virus particles. Expression of eIF-5A is vital for Rev function, and in
B-cell lymphomagenesis in SIV-immunosuppressed cynomolgus monkeys.: Int J Cancer. 1995 May 16;61(4):574-9. Unique Identifier : AIDSLINE MED/95279007; Rezikyan S; Kaaya EE; Ekman M; Voevodin AF; Feichtinger H; Putkonen P; Castanos-Velez E; Biberfeld G; Biberfeld P; Immunopathology Laboratory, Karolinska Institute, Stockholm,; Sweden.; B-cell lymphomas developed frequently (approx. 40%) in SIVsm (SMM3) immunosuppressed monkeys and were mostly extranodal, aggressive and all associated with an EBV-related simian herpes virus operationally designated herpes virus Macaca fascicularis (HVMF-I). Lymphoma tissues from 21 monkeys were studied by PCR and DNA
Adoptive transfer of ex vivo-activated memory T-cell subsets with cyclophosphamide provides effective tumor-specific chemoimmunotherapy of advanced metastatic murine melanoma and carcinoma.: Int J Cancer. 1995 May 16;61(4):580-6. Unique Identifier : AIDSLINE MED/95279008; Gold JE; Zachary DT; Osband ME; Department of Medicine, Mount Sinai Hospital, City University of; New York, NY, USA.; Autolymphocyte therapy (ALT) is adoptive cellular therapy of neoplastic disease using ex vivo activation of autologous (human) or syngeneic (murine) lymphocytes from tumor-bearing hosts (TBH) by low doses of anti-CD3 monoclonal antibody (MAb) and a mixture of previously prepared autologous cytokines (T3CS). Ex vivo ac
Geographic variation in HIV infection among injecting drug users with Barcelona.: Int J Addict. 1995 Jan;30(2):219-29. Unique Identifier : AIDSLINE MED/95279018; Roca J; Vlahov D; Borrell C; Jansa JM; Brugal T; Yazbeck H; Munoz A; Institut Municipal Salut, Barcelona, Spain.; In response to a high incidence of AIDS among injecting drug users in Barcelona, Spain , the city established a program in four geographically distinct centers for assistance and surveillance. The centers provided testing, counseling, and monitoring of infectious diseases. In 1991-92
Five girls in search of a group: a group experience for adolescents of parents with AIDS.: Int J Group Psychother. 1995 Apr;45(2):223-35. Unique Identifier : AIDSLINE MED/95279025; Aronson S; Bronx Municipal Hospital Center/Albert Einstein College of; Medicine, USA.; This paper depicts a pilot school-based bereavement group initiated by four junior-high-school girls who experienced crying spells and suicidal ideation following a classroom discussion on AIDS. It emerged that each of these youths had recently lost (or was in the process of losing) a close family member to the diseas
HIV infection presenting as renal polyarteritis nodosa.: Int Urol Nephrol. 1994;26(6):637-41. Unique Identifier : AIDSLINE MED/95279042; Angulo JC; Lopez JI; Garcia ME; Peiro J; Flores N; Department of Urology, Hospital de Basurto, Bilbao, Spain.; We present a case of renal vasculitis (polyarteritis nodosa) in a 36-year-old female prostitute having undetected HIV infection (AIDS-related complex) and chronic B-hepatitis. The pathogenesis and significance of the association between these entities are reviewed.
[Antiretroviral therapy of HIV infection. Current status]: Hautarzt. 1995 Mar;46(3):141-3. Unique Identifier : AIDSLINE MED/95279093; Petzoldt D; Hartmann M; Universitats-Hautklinik, Heidelberg.
Controversies in anti-retroviral therapy of adults.: J Antimicrob Chemother. 1995 Feb;35(2):245-62. Unique Identifier : AIDSLINE MED/95279252; Khoo SH; Wilkins EG; Department of Infectious Diseases and Tropical Medicine, North; Manchester General Hospital, UK.; Much controversy surrounds the use of antiretroviral drugs in HIV-infected patients. The many studies involving large numbers of patients that have been and are being conducted have raised as many questions as they have sought to answer. Given that no cure exists and that all clinically available drugs have only limit
Effect of digital nerve blockade on heat-induced vasoconstriction in the human finger.: J Appl Physiol. 1995 Feb;78(2):746-9. Unique Identifier : AIDSLINE MED/95279316; Sakurada S; Shido O; Yamamoto K; Sugimoto N; Kobayashi T; Nagasaka T; Department of Physiology, School of Medicine, Kanazawa; University, Japan.; The present study was performed to investigate the mechanism of heat-induced vasoconstriction (HIVC) in human fingers. The left fingers of five male subjects were immersed in water controlled at an initial temperature of 35.0 degrees C. The blood flows (BF) of the left index and fourth fingers were measured continuous
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.: J Biol Chem. 1995 May 26;270(21):12814-22. Unique Identifier : AIDSLINE MED/95279424; Brauweiler A; Garl P; Franklin AA; Giebler HA; Nyborg JK; Department of Biochemistry and Molecular Biology, Colorado State; University, Fort Collins 80523, USA.; The human T-cell leukemia virus type I (HTLV-I) is the causative agent of an aggressive T-cell malignancy in humans. While the virus appears to maintain a state of latency in most infected cells, high level virion production is an essential step in the HTLV-I life cycle. The virally-encoded Tax protein, a potent activ
The molecular structure of human antibodies specific for the human immunodeficiency virus.: J Clin Immunol. 1995 Jan;15(1):17-26. Unique Identifier : AIDSLINE MED/95279501; Andris JS; Capra JD; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235-9048, USA.; The molecular structure of human antibodies that are specific for human immunodeficiency virus-1 (HIV-1) are of increasing interest as AIDS research progresses toward passive immunotherapeutics in the maintenance and prevention of infection. In recent years a number of human, HIV-specific hybridomas and EBV-transforme
Perception of learning needs and preferred learning methods about AIDS/HIV among registered nurses working in the community in Texas.: J Contin Educ Nurs. 1995 May-Jun;26(3):129-34. Unique Identifier : AIDSLINE MED/95279532; Demirbag BC; Ridenour N; It is important for nurses and other healthcare workers to recognize that patients who present themselves for health care could already be infected with human immunodeficiency virus (HIV). Therefore, appropriate and sensible infection control precautions should be taken at all times. An assessment of nurses knowledge
HIV-positive children require increased dental care [news]: J Am Dent Assoc. 1995 May;126(5):558. Unique Identifier : AIDSLINE MED/95279590
Assessment of nutritional, clinical, and immunologic status of HIV-infected, inner-city patients with multiple risk factors.: J Am Diet Assoc. 1995 Jun;95(6):655-60. Unique Identifier : AIDSLINE MED/95279653; Luder E; Godfrey E; Godbold J; Simpson DM; Department of Pediatrics, Mt Sinai School of Medicine, New York,; NY 10029, USA.; OBJECTIVE: To evaluate the nutritional, clinical, and immunologic factors associated with human immunodeficiency virus (HIV)-infected, inner-city patients with multiple risk factors. DESIGN: Prospective cross-sectional nutrition evaluation of patients with HIV infection. SETTING: Patients were interviewed at the outpa
A community-based, interagency approach by dietitians to provide meals, medical nutrition therapy, and education to clients with HIV/AIDS.: J Am Diet Assoc. 1995 Jun;95(6):683-6. Unique Identifier : AIDSLINE MED/95279658; Topping CM; Humm DC; Fischer RB; Brayer KM; Clinical services, NutriSmart, Inc., Penfield, NY 14526, USA.; Dietitians have the opportunity to be leaders in providing medical nutrition therapy and home-delivered meals for people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in the community setting. Four community agencies developed the Visiting Nurse Service HIV/Home Delivered Meals Progra
Immunomodulatory and antiviral activities of 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-fluorocytidine.: Immunopharmacol Immunotoxicol. 1995 Feb;17(1):17-32. Unique Identifier : AIDSLINE MED/95279684; Gagnon L; Nordstrom PA; Duchaine J; Jutras D; Hamel M; Barbeau D; Hooker E; Ashman C; Cammack N; Tse A; et al; Virol./Immunol. Dept., BioChem Therapeutic Inc., Quebec, Canada.; Two dideoxynucleosides, 2 ,3 -dideoxy-beta-L-cytidine and 2 ,3 -dideoxy-beta-L-5-flurocytidine, containing unnatural L-configuration in their sugar moieties, were synthesized and assayed for antiviral activities. Both compounds were shown to possess potent anti-human immunodeficiency virus type 1 and antihepatitis B v
In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and leukemia-lymphoma cells.: Immunopharmacol Immunotoxicol. 1995 Feb;17(1):69-79. Unique Identifier : AIDSLINE MED/95279690; Zheng YT; Zhang WF; Ben KL; Wang JH; Kunming Institute of Zoology, Chinese Academy of Sciences,; Yunnan.; Trichosanthin (TCS) is a ribosome-inactivating protein from root tubers of Trichosanthes kirilowii Maxim. In this paper, the effects of TCS on the viability of human peripheral blood immunocytes, on the proliferation of lymphocytes, and its cytotoxicity to twelve cell lines of lymphoma or leukemia had been observed. T
Knowledge and attitudes of university students regarding HIV/AIDS: an urban--rural difference.: J Commun Dis. 1994 Dec;26(4):186-91. Unique Identifier : AIDSLINE MED/95279713; Lal P; Kumar A; Ingle GK; Gulati N; Department of Preventive and Social Medicine, Maulana Azad; Medical College, New Delhi.; A total of 322 students from two colleges of Delhi University, one located in urban and the other in the rural area were surveyed to assess and compare their knowledge, attitudes and beliefs regarding HIV/AIDS. A pretested and self-administered questionnaire containing mostly close ended questions was used. Observatio
Community based survey of STD/HIV infection among commercial sex-workers in Calcutta (India). Part-III: Clinical findings of sexually transmitted diseases (STD).: J Commun Dis. 1994 Dec;26(4):192-6. Unique Identifier : AIDSLINE MED/95279714; Das A; Jana S; Chakraborty AK; Khodakevich L; Chakraborty MS; Pal NK; All India Institute of Hygiene and Public Health, Calcutta.; On physical examination of 418 sex workers, 202 (48.32 per cent) were found to have vaginal discharge, which was found to be most common among younger age class. Endocervical pus, genital ulcer, and swelling of inguinal lymph glands were observed in 13.16, 6.22 and 1.91 per cent of the sex workers respectively. Clinic
Community based survey of STD/HIV infection among commercial sex workers in Calcutta (India). Part-IV: Sexually transmitted diseases and related risk factors.: J Commun Dis. 1994 Dec;26(4):197-202. Unique Identifier : AIDSLINE MED/95279715; Pal NK; Chakraborty MS; Das A; Khodakevich L; Jana S; Chakraborty AK; School of Tropical Medicine, Calcutta.; Community based survey on a sample of commercial sex workers in one red light area of Calcutta, was carried out to determine prevalence of sexually transmitted diseases (STD) including HIV infection and related risk factors. An alarmingly high prevalence of STDs (80.56 per cent) but low HIV-seropositivity (1.13 per ce
Surveillance of STD patients for AIDS using World Health Organisation criteria.: J Commun Dis. 1994 Dec;26(4):231-2. Unique Identifier : AIDSLINE MED/95279720; Khan MA; Giri TK; Mishra NM; Kailash S; Meena HS; All India Institute of Medical Sciences, New Delhi.
Court says hospital may restrict surgeon with HIV [news]: Infect Control Hosp Epidemiol. 1995 Feb;16(2):115. Unique Identifier : AIDSLINE MED/95279726
Plans under way to centralize AIDS program within CDC [news]: Infect Control Hosp Epidemiol. 1995 Feb;16(2):115. Unique Identifier : AIDSLINE MED/95279727
CDC responds to media reports that Florida dentist not source of HIV infection for six patients [news]: Infect Control Hosp Epidemiol. 1995 Feb;16(2):116-7. Unique Identifier : AIDSLINE MED/95279728
Apparent split tolerance of CD8+ T cells from beta 2-microglobulin-deficient (beta 2m-/-) mice to syngeneic beta 2m+/+ cells.: J Immunol. 1995 Jun 15;154(12):6252-61. Unique Identifier : AIDSLINE MED/95279777; Jhaver KG; Rao TD; Frey AB; Vukmanovic S; Department of Pathology, New York University Medical Center, New; York 10016, USA.; beta 2-microglobulin-deficient (beta 2m-/-) mice express reduced levels of MHC class I molecules and, consequently, have impaired positive selection of CD8+ T lymphocytes in the thymus. However, small numbers of CD8+ CTLs can be found in beta 2m-/- mice after immunization with allogeneic as well as syngeneic beta 2m+/
The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors.: J Immunol. 1995 Jun 15;154(12):6397-405. Unique Identifier : AIDSLINE MED/95279792; Hodge MR; Rooney JW; Glimcher LH; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115, USA.; Immune responses to pathogens often lead to the generation of polarized T helper subsets designated Th1 and Th2. Th1 cells, characterized by the production of IL-2 and IFN-gamma, stimulate cellular immune responses important for protection against intracellular pathoge
Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.: J Immunol. 1995 Jun 15;154(12):6466-74. Unique Identifier : AIDSLINE MED/95279799; Tahara H; Zitvogel L; Storkus WJ; Zeh HJ 3rd; McKinney TG; Schreiber RD; Gubler U; Robbins PD; Lotze MT; Department of Surgery, School of Medicine, Pittsburgh Cancer; Institute, University of Pittsburgh, PA 15213, USA.; Our recent studies using IL-12 protein or fibroblasts genetically engineered to secrete IL-12 have demonstrated profound antitumor effects of IL-12 in murine models. The antitumor effects of local, high level IL-12 expression were examined using a retroviral vector, which can express both IL-12 subunits (p35 and p40)
The human HIV/peripheral blood lymphocyte (PBL)-SCID mouse. A modified human PBL-SCID model for the study of HIV pathogenesis and therapy.: J Immunol. 1995 Jun 15;154(12):6612-23. Unique Identifier : AIDSLINE GENBANK/K03455; Boyle MJ; Connors M; Flanigan ME; Geiger SP; Ford H Jr; Baseler M; Adelsberger J; Davey RT Jr; Lane HC; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; PBL from HIV-infected patients were engrafted into CB-17 SCID mice to develop a novel small animal model for the study of HIV pathogenesis and therapy. Engraftment was achieved in 84% of mice, with human Ig (hu-Ig) levels and total human mononuclear cell recovery by peritoneal wash similar to those in control hu-PBL-S
CD30 and type 2 T helper (Th2) responses [published erratum appears in J Leukoc Biol 1995 Jun;57(6):978]: J Leukoc Biol. 1995 May;57(5):726-30. Unique Identifier : AIDSLINE MED/95279876; Romagnani S; Del Prete G; Maggi E; Chilosi M; Caligaris-Cappio F; Pizzolo G; Istituto di Clinica Medica 3, University of Florence, Italy.; CD30 is one of the members of the tumor necrosis factor receptor superfamily, originally described as a marker of Reed-Sternberg and Hodgkin s cells in Hodgkin s lymphoma. CD30 appears to be preferentially expressed on, and its soluble form (sCD30) released by, CD4+ and CD8+ T cell clones capable of producing T helper
GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells.: J Leukoc Biol. 1995 May;57(5):767-73. Unique Identifier : AIDSLINE MED/95279882; Shannon MF; Himes SR; Coles LS; Division of Human Immunology, Hanson Centre for Cancer Research,; Institute of Medical and Veterinary Science, Adelaide, South; Australia.; Antigen complexed with major histocompatibility complex class I or II molecules on the surface of antigen presenting cells interacts with the T cell receptor (TCR) on the surface of T cells and initiates an activation cascade. So called costimulatory signals, mediated by other cell surface interactions or soluble cyto
CD4 T cell development and cytokine polarization: an overview.: J Leukoc Biol. 1995 May;57(5):795-8. Unique Identifier : AIDSLINE MED/95279887; Swain SL; Department of Biology, University of California, San Diego, La; Jolla, 92093-0063, USA.; We have studied two key stages of CD4 development that serve as important checkpoints in determining whether a response will occur, how big it will be, and how long it will last. The response of naive CD4 cells is strictly regulated by the requirement for interaction of the potential precursor with an antigen-presenti
HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing [see comments]: J Exp Med. 1995 Jun 1;181(6):2253-7. Unique Identifier : AIDSLINE MED/95279952; Salemi S; Caporossi AP; Boffa L; Longobardi MG; Barnaba V; Istituto I Clinica Medica, Policlinico Umberto I, Universita di; Roma La Sapienza, Italy.; T cells are made tolerant only to those self-peptides that are presented in sufficient amounts by antigen-presenting cells. They ignore cryptic self-determinants, such as either those not generated by processing machinery or generated in insufficient amounts. It is anticipated that mechanisms that either change antige
Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.: J Exp Med. 1995 Jun 1;181(6):2283-7. Unique Identifier : AIDSLINE MED/95279957; Renno T; Hahne M; MacDonald HR; Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges,; Switzerland.; Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds to major histocompatibility complex class II molecules and selectively interacts with T cells that bear certain T cell receptor (TCR) V beta domains. Administration of SEB in adult mice results in initial proliferation of V beta 8+ T cells follo
Ahalaya Project providing assistance to HIV-infected Native Americans in OKC, Tulsa [news]: J Okla State Med Assoc. 1995 Mar;88(3):127-8. Unique Identifier : AIDSLINE MED/95280182
Human immunodeficiency virus and hepatitis B virus seroprevalence in an urban trauma population.: J Trauma. 1995 May;38(5):736-41. Unique Identifier : AIDSLINE MED/95280384; Sloan EP; McGill BA; Zalenski R; Tsui P; Chen EH; Duda J; Morris M; Sherer R; Barrett J; Department of Emergency Medicine, University of Illinois College; of Medicine, USA.; OBJECTIVE: To determine the seroprevalence of the human immunodeficiency virus (HIV) and the hepatitis B virus (HBV) in patients of an urban level I trauma center. DESIGN: Prospective, blinded point prevalence study of serum HIV and HBV antibody and antigen. SETTING: An urban level I trauma center that participates in
Mycobacterial infections and HIV.: Kekkaku. 1995 Apr;70(4):313-20. Unique Identifier : AIDSLINE MED/95280525; Chaisson RE; Johns Hopkins University, Baltimore, Maryland, USA.
Remission of substance use disorders: gay men in the first decade of AIDS.: J Stud Alcohol. 1995 Mar;56(2):226-32. Unique Identifier : AIDSLINE MED/95280554; Remien RH; Goetz R; Rabkin JG; Williams JB; Bradbury M; Ehrhardt AA; Gorman JM; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, New York 10032, USA.; OBJECTIVE: Participants in a 5-year prospective study of HIV-seropositive and seronegative gay men demonstrated a significant decline in the rate (from lifetime to current) of alcohol and other DSM-III-R psychoactive substance use disorders. The goal of the current study was to identify factors associated with the ces
Transmission of HIV in dialysis centre [see comments]: Lancet. 1995 Jun 3;345(8962):1417-22. Unique Identifier : AIDSLINE MED/95280601; Velandia M; Fridkin SK; Cardenas V; Boshell J; Ramirez G; Bland L; Iglesias A; Jarvis W; Colombian Field Epidemiology Training Program, Bogota.; In August, 1993, 13 dialysis patients at one dialysis centre in Colombia , South America, were found to be HIV positive, and this prompted an epidemiological investigation. We carried out a cohort study of all dialysis centre patient
Search for HIV-1 group O infection in Nigeria [letter] [see comments]: Lancet. 1995 Jun 3;345(8962):1436. Unique Identifier : AIDSLINE MED/95280610; Dada AJ; Olumide YM; Henrard DR; Phelps B; Pau CP; Quinn TC; Biggar RJ; O'Brien TR; Blattner WA
Reversible diabetes in patient with AIDS-related Kaposi's sarcoma treated with interferon alpha-2a [letter]: Lancet. 1995 Jun 3;345(8962):1438-9. Unique Identifier : AIDSLINE MED/95280616; Gori A; Caredda F; Franzetti F; Ridolfo A; Rusconi S; Moroni M
Preventive therapy for tuberculosis [letter; comment]: Lancet. 1995 Jun 3;345(8962):1439. Unique Identifier : AIDSLINE MED/95280617; Strachan DP; Millard JF; Maxwell JD
Preventive therapy for tuberculosis [letter; comment]: Lancet. 1995 Jun 3;345(8962):1439. Unique Identifier : AIDSLINE MED/95280618; Twumasi P Jr
Serum HIV-1 RNA and routine patient monitoring [letter; comment]: Lancet. 1995 Jun 3;345(8962):1441. Unique Identifier : AIDSLINE MED/95280624; Phillips AN; Sabin CA; Mocroft A
Serum HIV-1 RNA and routine patient monitoring [letter; comment]: Lancet. 1995 Jun 3;345(8962):1441-2. Unique Identifier : AIDSLINE MED/95280625; Strair R; Medina D
The lack of susceptibility to HIV-1 infection in human hematopoietic progenitor TF-1 cell line correlates with the absence of LFA-1 (CD11a) surface adhesion molecule.: New Microbiol. 1995 Jan;18(1):59-67. Unique Identifier : AIDSLINE MED/95280757; Furlini G; Re MC; Vignoli M; Ramazzotti E; Monari P; La Placa M; Institute of Microbiology, University of Bologna, Medical School,; St. Orsola, General Hospital, Italy.; Although substantially unsusceptible to HIV-1 infection, human hematopoietic progenitors (CD34+ cells) express significant amounts of gp120-binding CD4 molecules. As some experimental evidence suggests the need for one or more putative cellular accessory factor(s) for efficient CD4-mediate HIV-1 infection, we analyzed
Drug resistance of Mycobacterium tuberculosis strains isolated from HIV-infected Italian patients: preliminary report from a multicentric study. The Italian Tuberculosis Drug Resistance Study Group.: New Microbiol. 1995 Jan;18(1):69-72. Unique Identifier : AIDSLINE MED/95280758; Angarano G; Carbonara D; Costa D; A multicentric prospective study started in March 93 to describe both initial and acquired resistance of Mycobacterium Tuberculosis in Italian HIV+ patients (pts.) to first line drugs: Rifampin (R), Isoniazid (I), Pyrazinamide (P), Ethambutol (E), Streptomycin (S). All tuberculosis (TB) cases diagnosed in HIV+ patien
Cyclospora in AIDS patients: not always an agent of diarrhoic syndrome.: New Microbiol. 1995 Jan;18(1):73-6. Unique Identifier : AIDSLINE MED/95280759; Maggi P; Brandonisio O; Larocca AM; Rollo M; Panaro MA; Marangi A; Marzo R; Angarano G; Pastore G; Institute of Infectious Disease, University of Bari, Italy.; The present study reports the clinical features of two AIDS patients infected by Cyclospora. According to our observations, Cyclospora in AIDS can be responsible both for gastroenteritis and for asymptomatic infections with spontaneous rapid clearance. In addition, and undiagnosed circulation of this agent in
The tat gene and protein of the human immunodeficiency virus type 1.: New Microbiol. 1995 Jan;18(1):87-110. Unique Identifier : AIDSLINE MED/95280762; Caputo A; Grossi MP; Rossi C; Campioni D; Balboni PG; Corallini A; Barbanti-Brodano G; Institute of Microbiology, School of Medicine, University of; Ferrara, Italy.
The human immunodeficiency virus type 1 Rev protein and the Rev-responsive element counteract the effect of an inhibitory 5' splice site in a 3' untranslated region.: Mol Cell Biol. 1995 Jun;15(6):2962-71. Unique Identifier : AIDSLINE MED/95280894; Barksdale SK; Baker CC; Laboratory of Tumor Virus Biology, National Cancer Institute,; Bethesda, Maryland 20892-5055, USA.; A 5 splice site located in a 3 untranslated region (3 UTR) has been shown previously to inhibit gene expression. Natural examples of inhibitory 5 splice sites have been identified in the late 3 UTRs of papillomaviruses and are thought to inhibit viral late gene expression at early stages of the viral life cycle. In
A proliferative p53-responsive element mediates tumor necrosis factor alpha induction of the human immunodeficiency virus type 1 long terminal repeat.: Mol Cell Biol. 1995 Jun;15(6):3450-9. Unique Identifier : AIDSLINE MED/95280947; Gualberto A; Hixon ML; Finco TS; Perkins ND; Nabel GJ; Baldwin AS Jr; Lineberger Comprehensive Cancer Center, University of North; Carolina at Chapel Hill 27599-7295, USA.; Transforming mutants of the p53 tumor suppressor gene can positively regulate transcription from several promoters that do not contain known p53 binding sites. Here, we report the identification of a novel p53 binding site in the human immunodeficiency virus long terminal repeat that specifically mediates mutant p53 t
Human immunodeficiency virus [letter; comment]: N Engl J Med. 1995 Jun 22;332(25):1719. Unique Identifier : AIDSLINE MED/95280996; Arthur LO; Henderson LE; Benveniste RE
Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine [see comments]: N Engl J Med. 1995 Jun 29;332(26):1744-8. Unique Identifier : AIDSLINE MED/95281004; Gill PS; Harrington W Jr; Kaplan MH; Ribeiro RC; Bennett JM; Liebman HA; Bernstein-Singer M; Espina BM; Cabral L; Allen S; et al; Department of Internal Medicine, University of Southern; California School of Medicine, Los Angeles, USA.; BACKGROUND. Infection with the human T-cell lymphotropic virus type I, a retrovirus, can cause a distinctive cancer, adult T-cell leukemia-lymphoma. The median survival of patients with the acute and lymphomatous forms of the disease is short, despite the use of cytotoxic chemotherapy. METHODS. We treated 19 patients
Brief report: treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa [see comments]: N Engl J Med. 1995 Jun 29;332(26):1749-51. Unique Identifier : AIDSLINE MED/95281005; Hermine O; Bouscary D; Gessain A; Turlure P; Leblond V; Franck N; Buzyn-Veil A; Rio B; Macintyre E; Dreyfus F; et al; Department of Clinical Hematology, Hopital Necker, Paris,; France.
A surprising advance in the treatment of viral leukemia [editorial; comment]: N Engl J Med. 1995 Jun 29;332(26):1783-5. Unique Identifier : AIDSLINE MED/95281012; Gallo RC
Top aide to face charges in French HIV blood scandal [news]: Nature. 1995 Jun 1;375(6530):349. Unique Identifier : AIDSLINE MED/95281034; Tastemain C
Spinal tract pathology in AIDS: postmortem MRI correlation with neuropathology.: Neuroradiology. 1995 Feb;37(2):134-8. Unique Identifier : AIDSLINE MED/95281123; Santosh CG; Bell JE; Best JJ; MRI Unit, City Hospital, Edinburgh, Scotland.; Vacuolar myelopathy (VM) and tract pallor are poorly understood spinal tract abnormalities in patients with the acquired immunodeficiency syndrome (AIDS). We studied the ability of magnetic resonance imaging (MRI) to detect these changes in spinal cord specimens postmortem and whether criteria could be formulated whic
AIDS 1994 [news]: N Z Med J. 1995 Apr 26;108(998):158. Unique Identifier : AIDSLINE MED/95281185
HIV/AIDS in the workplace.: Occup Health Saf. 1995 May;64(5):79-80. Unique Identifier : AIDSLINE MED/95281188; Adler SK; American MSI Corp., Moorpark, Calif, USA.
Anti-interleukin-4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine schistosomiasis japonica.: Parasite Immunol. 1995 Feb;17(2):103-9. Unique Identifier : AIDSLINE MED/95281233; Cheever AW; Finkelman FD; Cox TM; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892, USA.; Anti-interleukin-4 (IL-4) treatment of Schistosoma japonicum-infected mice markedly inhibited in vitro secretion of the Th2 cytokines IL-4 and IL-5 from antigen-stimulated spleen cells, but enhanced the secretion of the Th1 cytokine IFN-gamma. IL-2 secretion was unaffe
Resistance to antivirals.: Pediatr Clin North Am. 1995 Jun;42(3):583-99. Unique Identifier : AIDSLINE MED/95281268; Laufer DS; Starr SE; Division of Allergy, Immunology, and Infectious Diseases,; Children's Hospital of Philadelphia, Pennsylvania, USA.; The ability of viruses to develop resistance to antiviral agents is already a major concern with respect to HIV. This article reviews mechanisms and clinical correlates of antiviral resistance and alternative drugs for treatment of infections due to resistant strains of HIV, herpes simplex virus,
Resistance to antifungal agents.: Pediatr Clin North Am. 1995 Jun;42(3):665-85. Unique Identifier : AIDSLINE MED/95281272; DeMuri GP; Hostetter MK; Department of Pediatrics, University of Minnesota, Minneapolis,; USA.; The marked increase in the number of patients with AIDS and other forms of immunocompromise has resulted in the emergence of fungi as predominant pathogens in many institutions. Unfortunately, with the widespread use of antifungal agents to combat these infections, reports of resistance to antifungal agents have proli
Calcifying arteriopathy in the basal ganglia in human immunodeficiency virus infection.: Pediatr Radiol. 1995;25(1):72-3. Unique Identifier : AIDSLINE MED/95281302; Bode H; Rudin C; Universitatskinderklinik, Ulm, Germany.; Echogenic stripes in the basal ganglia were identified sonographically in a 4-month-old infant with human immunodeficiency virus (HIV) infection. This lenticulostriate arteriopathy correlated well with histologically identified early alterations of HIV encephalopathy in children. At 3 years and 5 months, CT examinatio
Abnormally small adenoids in HIV-infected children.: Pediatr Radiol. 1995;25(1):74-6. Unique Identifier : AIDSLINE MED/95281303; Balsam D; Kanth N; Balbi H; Nassau County Medical Center, East Meadow, NY 11554, USA.; A number of diverse head and neck manifestations of HIV infection have been described, including adenoidal hypertrophy. We report a series of HIV-infected children in which 9 of 18 had abnormally small or radiographically absent adenoidal tissue. This finding did not, however, seem to correlate with several parameters
A critical review of studies evaluating the relationship of mode of delivery to perinatal transmission of human immunodeficiency virus.: Pediatr Infect Dis J. 1995 Mar;14(3):169-76; quiz 177. Unique Identifier : AIDSLINE MED/95281306; Mofenson LM; Adolescent and Maternal AIDS Branch, National Institute of Child; Health and Human Development, National Institutes of Health,; Bethesda, MD 20892-7510, USA.
Perinatal transmission and manifestation of hepatitis C virus infection in a high risk population.: Pediatr Infect Dis J. 1995 Mar;14(3):195-9. Unique Identifier : AIDSLINE MED/95281310; Paccagnini S; Principi N; Massironi E; Tanzi E; Romano L; Muggiasca ML; Ragni MC; Salvaggio L; Pediatric Department IV, University of Milan, Italy.; We studied the perinatal transmission of hepatitis C virus (HCV) in 70 high risk mother/infant pairs. Seventy-six percent of the mothers (53 of 70) were coinfected with human immunodeficiency virus (HIV) and 79% (55 of 70) had a history of drug addiction. During the follow-up HCV RNA was detected in 14 of 70 (20%) inf
Rifabutin-associated uveitis in a pediatric patient.: Pediatr Infect Dis J. 1995 Mar;14(3):246-7. Unique Identifier : AIDSLINE MED/95281324; Dunn AM; Tizer K; Cervia JS; Division of Pediatric Infectious Diseases and Immunology, New; York Hospital-Cornell Medical Center, NY, USA.
Diffusely disseminated cutaneous Leishmania major infection in a child with acquired immunodeficiency syndrome.: Pediatr Infect Dis J. 1995 Mar;14(3):247-9. Unique Identifier : AIDSLINE MED/95281325; Gillis D; Klaus S; Schnur LF; Piscopos P; Maayan S; Okon E; Engelhard D; Department of Pediatrics, Hadassah University Hospital,; Jerusalem, Israel.
Management of children with hypodermic needle injuries.: Pediatr Infect Dis J. 1995 Mar;14(3):254-5. Unique Identifier : AIDSLINE MED/95281329; Bell TA; Hagan HC; Lewis County Department of Human Services, Chehalis, WA, USA.
Lesbians, gay men, and their families. Some therapeutic issues.: Psychiatr Clin North Am. 1995 Mar;18(1):123-37. Unique Identifier : AIDSLINE MED/95281436; Mattison AM; McWhirter DP; HIV Neurobehavioral Research Center, San Diego, USA.; Although a body of scientific data about working with parents and families of gays and lesbians has not yet developed, there is a growing body of literature of an anecdotal and personal nature that has been cited. These works provide therapists with background information and clients needing assistance with guided rea
Increasing melanoma incidence: putatively explainable by retrotransposons. Experimental contributions of the xiphophorine Gordon-Kosswig melanoma system.: Pigment Cell Res. 1994 Dec;7(6):433-50. Unique Identifier : AIDSLINE GENBANK/S77502; Anders A; Petry H; Fleming C; Petry K; Brix P; Luke W; Groger H; Schneider E; Kiefer J; Anders F; Genetisches Institut, Justus Liebig-Universitat, Giessen,; Germany.; The worldwide accelerating increase of neoplasia in humans is difficult to explain. We use the Xiphophorus tumor model to approach this problem by melanoma provocation with X-rays. Melanoma develops following inappropriate expression of x-erb B-conducted developmental genes and their controllers. These oncodeterminant
[Differential lymphoid cell infiltrates diagnosis in bone marrow]: Pathologe. 1995 Mar;16(2):106-19. Unique Identifier : AIDSLINE MED/95281493; Thiele J; Institut fur Pathologie der Universitat zu Koln.; The purpose of this study was to provide criteria for the differentiation of reactive lymphoid hyperplasia (RLH) and focal involvement of the bone marrow by malignant lymphoma (ML). Using trephine bone-marrow biopsy specimens embedded in paraffin wax and unequivocally established samples with ML for comparison, all pa
[Tuberculosis in Africans hospitalized in Paris. Impact of infection by the human immunodeficiency virus]: Presse Med. 1995 Apr 1;24(13):601-5. Unique Identifier : AIDSLINE MED/95281500; Cabie A; Matheron S; Vallee E; Coulaud JP; Service des Maladies infectieuses et tropicales, Hopital; Bichat-Claude Bernard, Paris.; OBJECTIVES: Human immunodeficiency virus (HIV) infection has greatly modified the epidemiology and clinical course of tuberculosis. The aim of this study was to analyze the characteristics of tuberculosis in African patients hospitalized in Paris by comparing clinical features in patients with and without HIV infectio
CT-2576, an inhibitor of phospholipid signaling, suppresses constitutive and induced expression of human immunodeficiency virus.: Proc Natl Acad Sci U S A. 1995 May 23;92(11):4813-7. Unique Identifier : AIDSLINE MED/95281546; Leung DW; Peterson PK; Weeks R; Gekker G; Chao CC; Kaplan AH; Balantac N; Tompkins C; Underiner GE; Bursten S; et al; Cell Therapeutics, Inc., Seattle, WA 98119, USA.; Viruses such as human immunodeficiency virus (HIV) require cellular activation for expression. Cellular activation in lymphoid cells is associated with augmented accumulation of certain phosphatidic acid (PA) species derived from the hydrolysis of glycan phosphatidylinositol (GPI). This suggests that activation of a p
Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus.: Proc Natl Acad Sci U S A. 1995 May 23;92(11):4848-52. Unique Identifier : AIDSLINE MED/95281553; Downing JF; Pasula R; Wright JR; Twigg HL 3d; Martin WJ 2d; Division of Pulmonary and Critical Care Medicine, Indiana; University Medical Center, Indianapolis 46202, USA.; The incidence of tuberculosis is increasing on a global scale, in part due to its strong association with human immunodeficiency virus (HIV) infection. Attachment of Mycobacterium tuberculosis to its host cell, the alveolar macrophage (AM), is an important early step in the pathogenesis of infection. Bronchoalveolar l
SPC3, a synthetic peptide derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms.: Proc Natl Acad Sci U S A. 1995 May 23;92(11):4867-71. Unique Identifier : AIDSLINE MED/95281557; Yahi N; Fantini J; Baghdiguian S; Mabrouk K; Tamalet C; Rochat H; Van Rietschoten J; Sabatier JM; Laboratoire des Proteines, Faculte de Medecine Nord, Centre; National de la Recherche Scientifique, Marseille, France.; The third variable region (V3 loop) of gp120, the HIV-1 surface envelope glycoprotein, plays a key role in HIV-1 infection and pathogenesis. Recently, we reported that a synthetic multibranched peptide (SPC3) containing eight V3-loop consensus motifs (GPGRAF) inhibited HIV-1 infection in both CD4+ and CD4- susceptible
A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA.: Proc Natl Acad Sci U S A. 1995 May 23;92(11):5077-81. Unique Identifier : AIDSLINE MED/95281599; Chen L; Frankel AD; Department of Biochemistry and Biophysics, University of; California, San Francisco 94141, USA.; A 17-amino acid arginine-rich peptide from the bovine immunodeficiency virus Tat protein has been shown to bind with high affinity and specificity to bovine immunodeficiency virus transactivation response element (TAR) RNA, making contacts in the RNA major groove near a bulge. We show that, as in other peptide-RNA com
Viral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease.: Proc Natl Acad Sci U S A. 1995 May 23;92(11):5124-8. Unique Identifier : AIDSLINE MED/95281609; Manuelidis L; Sklaviadis T; Akowitz A; Fritch W; Yale Medical School, New Haven, CT 06510, USA.; Several models have been proposed for the infectious agents that cause human Creutzfeldt-Jakob disease (CJD) and sheep scrapie. Purified proteins and extracted nucleic acids are not infectious. To further identify the critical molecular components of the CJD agent, 120S infectious material with reduced prion protein (
Thoracic mycoses from endemic fungi: radiologic-pathologic correlation.: Radiographics. 1995 Mar;15(2):255-70. Unique Identifier : AIDSLINE MED/95281788; McAdams HP; Rosado-de-Christenson ML; Lesar M; Templeton PA; Moran CA; Department of Radiology, Walter Reed Army Medical Center,; Washington, DC, USA.; The endemic fungi Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis are primary human pathogens whose major portal of entry is the respiratory tract. Their clinical manifestations are categorized as acute, chronic or chronic progressive, or disseminated fungal disease. Most acute pulmonary inf
Upper respiratory tract infections in the immunocompromised host.: Semin Respir Infect. 1995 Mar;10(1):37-50. Unique Identifier : AIDSLINE MED/95281871; Morrison VA; Pomeroy C; Minneapolis Veterans Affairs Medical Center, MN 55417, USA.; Infections of the upper respiratory tract are a major source of morbidity and mortality in the immunocompromised host. The risks and types of infections are dictated by the specific immune defects present in the patient. Infections may involve virtually any of the structures in the upper respiratory tract, including t
[Pneumococcal bacteremia: what is new?]: Schweiz Med Wochenschr. 1995 May 13;125(19):952-8. Unique Identifier : AIDSLINE MED/95281965; Carey I; Glauser MP; Bille J; Departement de medecine interne, Centre hospitalier; universitaire vaudois, Lausanne.; 85 patients who displayed Streptococcus pneumoniae (S. pneumoniae) bacteremia during hospitalization at the CHUV between January 1990 and December 1991 are reviewed retrospectively to reassess the importance of this pathology after the introduction in Switzerland of antipneumo
Gallo to relocate [news]: Science. 1995 May 26;268(5214):1119. Unique Identifier : AIDSLINE MED/95281983
T helper cell subsets in insulin-dependent diabetes.: Science. 1995 May 26;268(5214):1185-8. Unique Identifier : AIDSLINE MED/95282001; Katz JD; Benoist C; Mathis D; Institut de Genetique et de Biologie Moleculaire et; Cellulaire, INSERM-CNRS-Universite Louis Pasteur, Illkirch, CU; de Strasbourg, France.; It has been proposed that the development of insulin-dependent diabetes is controlled by the T helper 1 (TH1) versus TH2 phenotype of autoreactive TH cells: TH1 cells would promote diabetes, whereas TH2 cells would actually protect from disease. This proposition was tested by establishing cultures of TH1 and TH2 cells
Cheaper test for tracking AIDS [news]: Science. 1995 Jun 2;268(5215):1281. Unique Identifier : AIDSLINE MED/95282014
Syndromes of pontine base infarction. A clinical-radiological correlation study.: Stroke. 1995 Jun;26(6):950-5. Unique Identifier : AIDSLINE MED/95282221; Kim JS; Lee JH; Im JH; Lee MC; Department of Neurology, University of Ulsan, Asan Medical; Center, Seoul, South Korea.; BACKGROUND AND PURPOSE: Although there have been sporadic reports of lacunar syndromes due to pontine base infarction, studies of clinical-radiological correlation in sufficient numbers of patients have not yet been reported. METHODS: We studied the clinical features of 37 patients with acute infarcts that mainly invo
Targeting HIV-1 protease: a test of drug-design methodologies.: Trends Pharmacol Sci. 1995 Feb;16(2):67-75. Unique Identifier : AIDSLINE MED/95282265; West ML; Fairlie DP; Centre for Drug Design and Development, University of Queensland,; Brisbane, Australia.; The proteinase of the human immunodeficiency virus (HIV-1 protease) is an obvious example of a receptor for which drug design methodologies have been successfully applied. In this article, Michael West and David Fairlie outline the specific progress made to date towards the rational design of
Enhancement of HIV antigen detection after acid dissociation of immune complexes is associated with loss of specificity [letter]: Vox Sang. 1995;68(2):132-3. Unique Identifier : AIDSLINE MED/95282425; Gutierrez M; Vallejo A; Soriano V
HIV-2 in native Spanish individuals. HIV-2 Spanish Study Group [letter]: Vox Sang. 1995;68(2):137-8. Unique Identifier : AIDSLINE MED/95282428; Soriano V; Gutierrez M; Caballero E; Fernandez JL; Carballo E; Aguilera A; Martin AM
Graft-versus-host disease after autologous bone marrow transplantation: a realistic expectation?: Wien Med Wochenschr. 1995;145(2-3):25-7. Unique Identifier : AIDSLINE MED/95282455; Niederwieser D; Eibl B; Nachbaur D; Department of Internal Medicine, University of Innsbruck,; Austria.; The immunobiological mechanisms involved in the manifestation of an autoaggressive disease after autologous bone marrow transplantation (BMT) and cyclosporine A (CyA) treatment are still unclear. This disease, which in animals shows clinical and histopathological features in the skin, liver and gut similar to those of
Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations.: Vaccine. 1995 Jan;13(1):45-53. Unique Identifier : AIDSLINE MED/95282489; Stieneker F; Kersten G; van Bloois L; Crommelin DJ; Hem SL; Lower J; Kreuter J; Institut fur Pharmazeutische Technologie, Johann Wolfgang; Goethe-Universitat, Frankfurt am Main-Niederusel, Germany.; The objective of this study was the comparison of the quantity and quality of the humoral immune response against inactivated whole human immunodeficiency virus type 2. Twenty-four different adjuvants were tested. The toxicity of these preparations was determined. Due to the large number of experiments, the animal mod
An experimental chemically inactivated HIV-1 vaccine induces antibodies that neutralize homologous and heterologous viruses.: Vaccine. 1995 Jan;13(1):54-60. Unique Identifier : AIDSLINE MED/95282490; Race E; Frezza P; Stephens DM; Davis D; Polyanskaya N; Cranage M; Oxford JS; Department of Academic Virology and Retroscreen Ltd, London; Hospital Medical College, Whitechapel, UK.; We have developed a unique multiple step procedure to inactivate human immunodeficiency virus chemically with a very high safety margin while retaining antigenically active structural virion proteins, including gp120, in the final immunogen. The whole virus preparation (1-10 micrograms per dose) was highly immunogenic
Human immunodeficiency virus-1 principal neutralizing domain peptide-toxin A conjugate vaccine.: Vaccine. 1995 Jan;13(1):67-71. Unique Identifier : AIDSLINE MED/95282493; Cryz SJ Jr; Goldstein H; Pettoello-Mantovani M; Kim A; Furer E; Que JU; Hasler T; Rubinstein A; Swiss Serum and Vaccine Institute, Berne.; To enhance the potential efficacy of peptide-based vaccines for human immunodeficiency virus-1 (HIV-1), a principal neutralizing domain (PND) peptide (KRIHIGPGRAFYT) (HIV-1MN) was covalently coupled to Pseudomonas aeruginosa toxin A (TA). Immunization of guinea-pigs with this conjugate vaccine, in the absence of an ad
Diagnosis of histoplasmosis in bronchoalveolar lavage fluid [letter]: Acta Cytol. 1995 May-Jun;39(3):595-6. Unique Identifier : AIDSLINE MED/95282574; Gallardo J; Sasal M; Ferreres JC
Positive PPD and chemoprophylaxis for tuberculosis infection.: Am Fam Physician. 1995 Jun;51(8):1929-34, 1937-8. Unique Identifier : AIDSLINE MED/95282705; Pickwell SM; Department of Family and Preventive Medicine, University of; California, San Diego, School of Medicine, USA.; The appearance of an indurated area of 5 mm or more 48 to 72 hours after administration of purified protein derivative (PPD) is considered a positive reaction in persons who have recently had close contact with an individual with active tuberculosis, in persons with radiographic findings consistent with a past history
Outcomes of a 21-day drug detoxification program: retention, transfer to further treatment, and HIV risk reduction.: Am J Drug Alcohol Abuse. 1995 Feb;21(1):1-16. Unique Identifier : AIDSLINE MED/95282759; McCusker J; Bigelow C; Luippold R; Zorn M; Lewis BF; Department of Clinical Epidemiology, Centre Hospitalier de St.; Mary, Montreal, Quebec, Canada.; We investigated the outcomes of a 21-day inpatient drug detoxification and rehabilitation program including length of stay, transfer to further treatment, and HIV risky behavior. Clients (n = 567) were predominantly White, male, currently unemployed, and their treatment was not covered by third party payment. 78% were
Another wall that crumbled--methadone maintenance treatment in Germany.: Am J Drug Alcohol Abuse. 1995 Feb;21(1):27-35. Unique Identifier : AIDSLINE MED/95282764; Newman RG; Beth Israel Medical Center, New York, New York 10003, USA.; During the past quarter-century there have been innumerable reports throughout the world documenting the effectiveness of methadone maintenance treatment. None have been as consistently positive as those from Germany , where just a few years ago methadone was effectively banned. Th
The impact on behavior of notifying methadone patients of their HIV serostatus.: Am J Drug Alcohol Abuse. 1995 Feb;21(1):37-45. Unique Identifier : AIDSLINE MED/95282765; Katz SM; Galanter M; Lifshutz H; Maslansky R; Department of Psychiatry, New York University School of Medicine,; New York 10016, USA.; Questions have arisen about the implications of notifying drug abusers of their HIV serostatus. One major concern is that awareness of HIV infection would have a negative impact on abstinence from drug abuse. In order to ascertain the effects of serostatus notification, the authors reviewed the clinical records of 73
HIV risk-related behaviors among injection drug users in Rome: differences between 1990 and 1992.: Am J Public Health. 1995 Jun;85(6):829-32. Unique Identifier : AIDSLINE MED/95282959; Davoli M; Perucci CA; Abeni DD; Arca M; Brancato G; Forastiere F; Montiroli PM; Zampieri F; Epidemiology Unit, Regional Health Authority, Rome, Italy.; Temporal differences in human immunodeficiency virus (HIV) risk-related behaviors among injection drug users in Rome, Italy , were analyzed in 487 drug users recruited in 1990 and 450 recruited in 1992. Sharing of syringes decreased among self-reported HIV-positive drug users between
HIV, sexually transmitted disease, and tuberculosis testing at community sites in upstate New York [news]: Am J Public Health. 1995 Jun;85(6):867-8. Unique Identifier : AIDSLINE MED/95282969; Chaffee BH; Moehring S; Pruden S
The Houston Advance DATAR Follow-Up project: private investigator techniques for public health [news]: Am J Public Health. 1995 Jun;85(6):868-9. Unique Identifier : AIDSLINE MED/95282970; Johnson J; Williams ML; Chatham L
[Condom: its role in the prevention of AIDS]: Ann Pharm Fr. 1995;53(2):60-5. Unique Identifier : AIDSLINE MED/95283193; Lestradet H; Since no effective vaccination is available, protection is our only arm against the spread of the human immunodeficiency virus. For public health officials and associations working against the spread of AIDS, the contraceptive is the ultimate arm and only generalized use will change the course of the pandemia. But bec
Serum parathyroid hormone concentrations in patients with HIV infection.: Ann Clin Biochem. 1995 Jan;32 ( Pt 1):94-5. Unique Identifier : AIDSLINE MED/95283212; St John A; Hoad K; Mallon D; French M; Department of Biochemistry, Royal Perth Hospital, Western; Australia.
The therapeutic efficacy of murine anti-tumor T cells: freshly isolated T cells are more therapeutic than T cells expanded in vitro.: Anticancer Res. 1995 Mar-Apr;15(2):441-7. Unique Identifier : AIDSLINE MED/95283273; Evans R; Kamdar SJ; Duffy TM; Krupke DM; Fuller JA; Dudley ME; Jackson Laboratory, Bar Harbor, Maine 04609, USA.; Adoptive immunotherapy (AIT) involving transfer of tumor-sensitized T lymphocytes in combination with cyclophosphamide (CY)-injection results in the eradication of the C57BL/6J (B6) rhabdomyosarcoma, 76-9 and is associated with the accumulation of a large number of tumor-infiltrating lymphocytes (TIL). Using immune sp
The challenge of diagnosing childhood tuberculosis in a developing country.: Arch Dis Child. 1995 Apr;72(4):369-74. Unique Identifier : AIDSLINE MED/95283350; Osborne CM; University Teaching Hospital, Department of Paediatrics and Child; Health, Lusaka, Zambia.
Pneumocystis carinii pneumonia without acquired immunodeficiency syndrome. More patients, same risk [editorial]: Arch Intern Med. 1995 Jun 12;155(11):1125-8. Unique Identifier : AIDSLINE MED/95283395; Sepkowitz KA; Brown AE; Armstrong D
[Pyrido(3,2-e)(1,4)diazepines--synthesis and testing of anti-HIV-1 activity]: Arch Pharm (Weinheim). 1995 Mar;328(3):247-55. Unique Identifier : AIDSLINE MED/95283420; Gorlitzer K; Wilpert C; Rubsamen-Waigmann H; Suhartono H; Wang L; Immelmann A; Institut fur Pharmazeutische Chemie, Technischen Universitat; Braunschweig.; Starting from the commercially available 6-methyl-2-pyridylamine (1) the pyrido[3,2-e][1,4]diazepine 14a was synthesized in 12 steps with 7% total yield. 14a, the N-methyl derivative 14b, the thiolactam 15a, the amidine 16, and the 1,2,4-triazole 17 were tested for anti-HIV-1-activity. None of the compounds tested pos
Cerebral single-photon emission computed tomography abnormalities in human immunodeficiency virus type 1-infected gay men without cognitive impairment.: Arch Neurol. 1995 Jun;52(6):607-11. Unique Identifier : AIDSLINE MED/95283491; Sacktor N; Prohovnik I; Van Heertum RL; Dooneief G; Gorman J; Marder K; Todak G; Stern Y; Mayeux R; Gertrude H. Sergievsky Center, Columbia University, New York, NY; 10032, USA.; OBJECTIVE: To determine whether technetium Tc99m exametazime single-photon computed emission tomography (SPECT) can distinguish gay human immunodeficiency virus (HIV)-positive subjects, both with and without mild cognitive impairment, from gay HIV-negative control subjects. DESIGN: Twenty HIV-positive subjects (12 wit
Interleukin-8 induces its own production in CD4+ T lymphocytes: a process regulated by interleukin 10.: Biochem Biophys Res Commun. 1995 May 25;210(3):660-9. Unique Identifier : AIDSLINE MED/95283523; Gesser B; Deleuran B; Lund M; Vestergard C; Lohse N; Deleuran M; Jensen SL; Pedersen SS; Thestrup-Pedersen K; Larsen CG; Department of Dermatology, Marselisborg Hospital, University of; Aarhus, Denmark.; The neutrophil and T cell chemotactic factor interleukin 8 (IL-8) is believed to play a pathophysiological role in the development of various inflammatory disorders. So far no other effects of IL-8 on T cells have been observed. We observed that purified CD4+ T cells in particular, but also CD8+ T cells, spontaneously
Nicotinamide inhibits HIV-1 in both acute and chronic in vitro infection.: Biochem Biophys Res Commun. 1995 May 25;210(3):954-9. Unique Identifier : AIDSLINE MED/95283561; Murray MF; Srinivasan A; Department of Medicine, Univ. of PA School of Medicine,; Philadelphia, USA.; HIV-1 infected patients can manifest a number of poorly understood conditions including dermatitis, dementia , and diarrhea. These conditions are in some ways suggestive of pellagra, the syndrome associated with niacin depletion. We demonstrate here that nicotinamide, the amide form
[X-ray structural study of 3'-O-methylthiomethylthymidine and 3'-O-methylsulfinylmethylthymidine--potential inhibitors of HIV]: Bioorg Khim. 1995 Mar;21(3):206-11. Unique Identifier : AIDSLINE MED/95283616; Bochkarev AV; Zavgorodnii SG; Zhdanov AS; Gurskaia GV; The molecular and crystalline structures of deoxiribonucleoside analogs: 3 -O-methylthiomethylthymidine monohydrate dT(CH2SMe).H2O and 3 -O-methylsulphinylmethylthymidine dT(CH2SOMe) were determined. The space group of dT(CH2SMe).H2O crystals is P2(1), the parameters of the elementary cell are a = 10.417(1), b = 4.912
Dentists' willingness to treat high risk patients [letter; comment]: Br Dent J. 1995 May 6;178(9):327. Unique Identifier : AIDSLINE MED/95283860; Williams KV
Early immune response and HIV progression [news]: Nurs Stand. 1995 Apr 12-18;9(29):12. Unique Identifier : AIDSLINE MED/95283912; Voelker R
Sexual health: a natural remedy.: Nurs Stand. 1995 Apr 12-18;9(29):46-7. Unique Identifier : AIDSLINE MED/95283921; Howe J
Cyclohexylamine inhibits the adhesion of lymphocytic cells to human syncytiotrophoblast.: Biochim Biophys Acta. 1995 May 12;1266(3):229-34. Unique Identifier : AIDSLINE MED/95284136; Douglas GC; Hu J; Thirkill TL; Hovanes K; Fuller M; King BF; Department of Cell Biology and Human Anatomy, School of Medicine,; University of California, Davis 95616-8643, USA.; We have previously shown that lymphocytic cells adhere to cultured syncytiotrophoblast and that this may be important in the lymphocyte-mediated infection of trophoblast with the human immunodeficiency virus (HIV). During the course of studies aimed at investigating the role of cell surface carbohydrates in adhesion,
The roads travelled.: Biometrics. 1995 Mar;51(1):1-11. Unique Identifier : AIDSLINE MED/95284226; Billard L
Change points in the series of T4 counts prior to AIDS.: Biometrics. 1995 Mar;51(1):236-48. Unique Identifier : AIDSLINE MED/95284239; Kiuchi AS; Hartigan JA; Holford TR; Rubinstein P; Stevens CE; Department of Statistics, Yale University, New Haven, Connecticut; 06511, USA.; The absolute number of T4 cells has been established as an important clinical marker of disease progression to acquired immunodeficiency syndrome (AIDS) in persons infected with human immunodeficiency virus (HIV). Series of T4 counts are analyzed from the 131 homosexual men who entered the New York Blood Center Study
Statistical inference in stationary populations.: Biometrics. 1995 Mar;51(1):347-50. Unique Identifier : AIDSLINE MED/95284249; Nagelkerke NJ; Department of Medical Microbiology, University of Nairobi, Kenya.; A fixed ensemble of alternating renewal processes is proposed as a model for stationary populations. This model is applied to explore the relationship between survival times and forward recurrence times. In addition, it is shown that ergodic theory can be applied to the model. An example is presented.
Statistical models for prevalent cohort data [letter; comment]: Biometrics. 1995 Mar;51(1):373-5. Unique Identifier : AIDSLINE MED/95284253; Ripley BD; Solomon PJ
Modelling age-specific survival in nesting studies, using a general approach for doubly-censored and truncated data.: Biometrics. 1995 Mar;51(1):51-60. Unique Identifier : AIDSLINE MED/95284257; Heisey DM; Nordheim EV; Department of Surgery, University of Wisconsin-Madison 53792,; USA.; In typical nest survival studies, the observed sample of nests is usually biased by left-truncation (i.e., only active nests enter the study); additionally the failure data may be doubly censored, because the exact dates of nest initiation and failure are uncertain. We present a general bivariate contingency table app
Design of B-DNA cross-linking and sequence-reading molecules.: Biopolymers. 1995 May;35(5):543-53. Unique Identifier : AIDSLINE MED/95284282; Walker WL; Kopka ML; Filipowsky ME; Dickerson RE; Goodsell DS; Molecular Biology Institute, University of California at Los; Angeles 90095, USA.; We report the design of hybrid molecules to bind in the minor groove of B-DNA, which combine DNA alkylating and cross-linking ability for increased chemotherapeutic efficacy, with sequence specificity, to minimize side effects. Optimal linkage geometries have been determined for the synthesis of bis-anthramycin and an
[The incidence and mortality of tuberculosis in children in Romania in recent years]: Pneumoftiziologia. 1994 Jul-Dec;43(3-4):185-8. Unique Identifier : AIDSLINE MED/95284585; Didilescu D; Marica C; Jalba M; Institutul de Pneumoftiziologie Marius Nasta, Bucuresti.; The incidence and mortality by tuberculosis in children vary in connection with the tuberculosis in adults. The incidence by tuberculosis in children decreased from 300-313/1000 in 1955-1960 at 7-8%000 in 1985. After the year 1985 the risk of tuberculosis in children had a very clear tendency to increase, from 7.4%000
Reprimun--an antibiotic with large spectrum and immunomodulatory properties.: Pneumoftiziologia. 1994 Jul-Dec;43(3-4):189-95. Unique Identifier : AIDSLINE MED/95284586; Paunescu E; Marius Nasta Institute of Pneumophthisiology, Bucharest.; Reprimun contains an oxyminomethyl rifamycin-SV derivative as the active substance and has a large spectrum antibiotic activity, on Mycobacterium tuberculosis too. Reprimun also shows an inhibitory activity on viral and human lymphocyte reverse transcriptases, an antiproliferative effect on retrovirus, as well as a se
[The clinico-radiological aspects in the association of AIDS-HIV virus infection and lung diseases]: Pneumoftiziologia. 1994 Jul-Dec;43(3-4):201-10. Unique Identifier : AIDSLINE MED/95284588; Marta D; Institutul de Pneumoftiziologie Marius Nasta, Bucuresti.
Health promotion in human immunodeficiency virus-infected patients through psychosocial interventions.: Nurse Pract Forum. 1995 Mar;6(1):40-5. Unique Identifier : AIDSLINE MED/95284614; Cooper CM; The extreme fear, prejudice, and stigmatization associated with human immunodeficiency virus disease make the acquired immune deficiency syndrome epidemic a unique phenomenon of the modern era. A fundamental understanding of the phychosocial issues surrounding the disease is essential, if nurses are to design interven
French doctors lack knowledge of AIDS [news]: BMJ. 1995 May 6;310(6988):1158. Unique Identifier : AIDSLINE MED/95284626; Dorozynski A
Gallo gets ready to try the other fork in the road [news]: BMJ. 1995 May 6;310(6988):1160. Unique Identifier : AIDSLINE MED/95284629; Roberts J
Delhi plans sperm donor laws [news]: BMJ. 1995 May 13;310(6989):1224. Unique Identifier : AIDSLINE MED/95284676; Mudur M
HIV infection in prisons. High risk behaviour is common in prisons in Berlin [letter; comment]: BMJ. 1995 May 13;310(6989):1264. Unique Identifier : AIDSLINE MED/95284689; Muller R; Stark K; Guggenmoos-Holzmann I
HIV infection in prisons. Most drug injectors stop injecting on entry to prison [letter]: BMJ. 1995 May 13;310(6989):1264. Unique Identifier : AIDSLINE MED/95284690; Shewan D; Reid M; Macpherson A; Davies JB
HIV infection in prisons. Genitourinary medicine services are important [letter; comment]: BMJ. 1995 May 13;310(6989):1264-5. Unique Identifier : AIDSLINE MED/95284691; Hillman R; Scoular A; McMillan S
HIV infection in prisons. Testing in prison is uncommon [letter; comment]: BMJ. 1995 May 13;310(6989):1265. Unique Identifier : AIDSLINE MED/95284692; Maguire H; Birthistle K; Carrington D; McManus T
Prevalence of HIV infection [letter; comment]: BMJ. 1995 May 13;310(6989):1268. Unique Identifier : AIDSLINE MED/95284705; Thornton JG
Lack of relationship between human immunodeficiency virus infection and systemic lupus erythematosus.: Lupus. 1995 Feb;4(1):47-9. Unique Identifier : AIDSLINE MED/95284837; Font J; Vidal J; Cervera R; Lopez-Soto A; Miret C; Jimenez de Anta MT; Ingelmo M; Department of Internal Medicine, Hospital Clinic, Barcelona,; Catalonia, Spain.; The objective of this work was to determine whether HIV-1 and HIV-2 could be involved in the pathogenesis of systemic lupus erythematosus (SLE). Seventy-five consecutive Caucasian patients with SLE presenting at one institution over a 2-year period were studied. Serum samples were surveyed for anti-HIV-1 antibodies by
Effect of the conformation of a peptide from gp41 on binding and domain formation in model membranes.: Mol Membr Biol. 1995 Jan-Mar;12(1):77-82. Unique Identifier : AIDSLINE MED/95284892; Koenig BW; Bergelson LD; Gawrisch K; Ward J; Ferretti JA; Laboratory of Biophysical Chemistry, NHLBI, NIH, Bethesda, MD; 20892-0380, USA.; Binding of the peptide fragment 828-848 (P828), amino acid sequence RVIEVVQGACRAIRHIPRRIR, from the carboxy-terminal region of the envelope glycoprotein gp41 of human immunodeficiency virus type 1 (HIV-1) to membranes composed of a mixture of neutral and negatively charged phospholipids results in domain or cluster fo
Role of interactions at the lipid-water interface for domain formation.: Mol Membr Biol. 1995 Jan-Mar;12(1):83-8. Unique Identifier : AIDSLINE MED/95284893; Gawrisch K; Barry JA; Holte LL; Sinnwell T; Bergelson LD; Ferretti JA; Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH,; Rockville, MD 20852, USA.; The lipid-water interface is critical for the packing of lipid molecules in membranes. We have demonstrated that lateral phase separation in membranes can be driven by electrostatic interactions such as those involving charged lipid species and oppositely charged peptides, in addition to hydration effects at the lipid
Confidential unit exclusion: the North London Blood Transfusion Centre's experience.: Transfus Med. 1995 Mar;5(1):51-6. Unique Identifier : AIDSLINE MED/95284903; Brennan MT; Hewitt PE; Moore C; Hall G; Barbara JA; NLBTC, U.K.; A Confidential AIDS Questionnaire has been used at North London Blood Transfusion Centre (NLBTC) donor sessions since July, 1985. The aim of the questionnaire is to encourage self-exclusion by those donors whose behaviour puts them at risk of HIV infection. In a situation where such individuals cannot avoid donating
Case study: ethics consultation.: J Law Med Ethics. 1994 Winter;22(4):347-50. Unique Identifier : AIDSLINE MED/95284916; Spike J; Greenlaw J
The HIV information project for transfusion recipients a decade after transfusion.: Arch Pediatr Adolesc Med. 1995 Jun;149(6):680-5. Unique Identifier : AIDSLINE MED/95284931; King SM; Murphy T; Corey M; Newman AM; Major C; McCrindle BW; Irwin J; Stevens M; Fearon M; Poon AO; Division of Infectious Diseases, Hospital for Sick Children,; University of Toronto, Ontario.; OBJECTIVE: To gather information on which to base decisions about a general notification program for pediatric patients a decade after their receiving transfusions. DESIGN: The physicians of a cohort of 1793 patients who underwent cardiac surgery were sent letters asking them to contact and counsel patients identified
AIDS and the gender gap.: Nurs Spectr (Wash D C). 1995 May 30;5(11):7. Unique Identifier : AIDSLINE MED/95284982
Experimental hypersensitivity pneumonitis: effect of Thy1.2+ and CD8+ cell depletion.: Am J Respir Crit Care Med. 1995 Jun;151(6):1834-42. Unique Identifier : AIDSLINE MED/95285036; Schuyler M; Gott K; Edwards B; Nikula KJ; Department of Medicine, Albuquerque VA Medical Center, University; of New Mexico School of Medicine.; We previously demonstrated that recipient CD4+ cells are necessary for expression of adoptive murine experimental hypersensitivity pneumonitis (EHP). In contrast, the acute inflammatory response to intratracheal (i.t.) administration of Micropolyspora faeni (direct EHP) is not CD4+ cell dependent (Am. J. Respir. Crit.
Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful?: Am J Respir Crit Care Med. 1995 Jun;151(6):1866-71. Unique Identifier : AIDSLINE MED/95285042; Huang L; Hecht FM; Stansell JD; Montanti R; Hadley WK; Hopewell PC; Medicine Service, San Francisco General Hospital Medical Center,; California, USA.; In U.S. patients with the acquired immunodeficiency syndrome (AIDS), Pneumocystis carinii pneumonia is the most frequent AIDS-defining opportunistic infection. Sputum induction and bronchoscopy are effective techniques for obtaining specimens used to identify P. carinii although debate continues over their optimal use
Lessons from the Concorde trial [letter]: Br J Hosp Med. 1995 Mar 15-Apr 4;53(6):296. Unique Identifier : AIDSLINE MED/95285090; Gazzard BG
Gene therapy for HIV infection.: Br Med Bull. 1995 Jan;51(1):149-66. Unique Identifier : AIDSLINE MED/95285151; Lever AM; University of Cambridge, Department of Medicine, Addenbrooke's; Hospital, UK.; The genetic approach to HIV infection is still very young and a number of different stages in the viral life cycle are being studied as targets for gene therapy, using a wide variety of modalities for gene delivery. Several gene therapy protocols for AIDS have been approved and when this article is published these may
Providing care to pediatric AIDS patients [interviews by Adem Ezra Segal-Isaacson]: NP News. 1995 Jan-Feb;3(1):10. Unique Identifier : AIDSLINE MED/95285365; Donovan P; Ayoob KT
Nursing and nutrition: providing complementary care.: NP News. 1995 Jan-Feb;3(1):6, 9-10. Unique Identifier : AIDSLINE MED/95285368; Segal-Isaacson AE
Controlling the rise in tuberculosis among the homeless.: NP News. 1995 Mar-Apr;3(2):3, 6. Unique Identifier : AIDSLINE MED/95285375; Valvassori P
[Evaluation of immunologic efficacy of AIDS vaccines]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1995 Feb;16(1):40-1. Unique Identifier : AIDSLINE MED/95285473; Zhang M
In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothioate in rats.: Clin Chem. 1995 Jun;41(6 Pt 1):836-43. Unique Identifier : AIDSLINE MED/95285567; Zhang R; Lu Z; Zhang X; Zhao H; Diasio RB; Liu T; Jiang Z; Agrawal S; Department of Pharmacology and Toxicology, University of Alabama; at Birmingham 35294, USA.; The use of antisense oligonucleotides represents a novel, genetically based therapy. The biostability and pharmacokinetics of a 33-mer self-stabilized oligodeoxynucleotide with significant anti-HIV activity was determined in rats after intravenous administration of [35S]oligodeoxynucleotide. Plasma disappearance of th
Saliva and serum neopterin concentrations not significantly correlated in HIV-1 infection [letter]: Clin Chem. 1995 Jun;41(6 Pt 1):950-1. Unique Identifier : AIDSLINE MED/95285591; Evans MR; Wansbrough-Jones MH
Autoreactivity in HIV-1 infection: the role of molecular mimicry.: Clin Immunol Immunopathol. 1995 Jun;75(3):197-205. Unique Identifier : AIDSLINE MED/95285607; Silvestris F; Williams RC Jr; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Italy.; Autoimmunity during HIV-1 infection may contribute to the immunopathogenesis of AIDS. Titers of autoantibodies to HLA molecules and other surface markers of CD4+ T cells appear to increase with the progression of disease and may correlate with lymphopenia. Other autoantibodies are directed at a number of regulatory mo
Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD8 T-lymphocytes.: Clin Immunol Immunopathol. 1995 Jun;75(3):239-45. Unique Identifier : AIDSLINE MED/95285612; Slater LM; Sweet P; Stupecky M; Reynolds JT; Department of Medicine, University of California at Irvine 92717,; USA.; The role of the immune response in the chemotherapeutic cure of an intact host with neoplasia is not well defined. We have previously shown that the addition of cyclosporin A to VP-16 therapy of BDF/1 mice with L1210 leukemia produces immunity to leukemia in long-surviving host animals. We now characterize this immuni
Community-acquired pneumonia in the intensive care unit.: Clin Chest Med. 1995 Mar;16(1):155-71. Unique Identifier : AIDSLINE MED/95285664; Leeper KV Jr; Torres A; Division of Pulmonary and Critical Care Medicine, University of; Tennessee, Memphis, USA.; CAP requiring ICU admission is a distinct clinical entity. The mortality rate of pneumonia in this subset of patients has been unchanged in the past several years. Aggressive diagnostic of strategies to establish the causative pathogens of pneumonia rapidly will enable clinicians to adjust antibiotic therapy appropria
Management of children with human immunodeficiency virus infection.: Compr Ther. 1995;21(3):139-47. Unique Identifier : AIDSLINE MED/95285677; Brady MT; College of Medicine, Ohio State University, Columbus, USA.
Multicenter trial of octreotide in patients with refractory acquired immunodeficiency syndrome-associated diarrhea [see comments] [published erratum appears in Gastroenterology 1995 Sep;109(3):1024]: Gastroenterology. 1995 Jun;108(6):1753-60. Unique Identifier : AIDSLINE MED/95285990; Simon DM; Cello JP; Valenzuela J; Levy R; Dickerson G; Goodgame R; Brown M; Lyche K; Fessel WJ; Grendell J; et al; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York, USA.; BACKGROUND/AIMS: Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea. METHODS: In a 3-week protocol, 129 patients with a stool weight of > 500 g/day despite standard antidiar
Octreotide therapy for human immunodeficiency virus--associated diarrhea: pitfalls in drug development [editorial; comment]: Gastroenterology. 1995 Jun;108(6):1939-41. Unique Identifier : AIDSLINE MED/95286014; Kotler DP
[AIDS: risk due to the endogenous immune system. HIV is not primarily cytopathic (news)]: Fortschr Med. 1995 Apr 20;113(11):30, 32. Unique Identifier : AIDSLINE MED/95286114; Moosmann EB
Two-phase approach for the expression of high-affinity human anti-human immunodeficiency virus immunoglobulin Fab domains in Escherichia coli.: Hybridoma. 1995 Feb;14(1):9-18. Unique Identifier : AIDSLINE GENBANK/L01413; Takeda S; Dorfman NA; Robert-Guroff M; Notkins AL; Rando RF; Laboratory of Oral Medicine, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland; 20892, USA.; We describe here a two-phase approach for the development of high-affinity human anti-HIV immunoglobulin Fab domains in a bacterial expression system. The first phase of this technique involves the generation of human hybridoma cell lines producing high-affinity antibodies (MAbs). Anti-HIV-1 human MAbs from peripheral
Spontaneous generation of human CD8+ TCR alpha beta+ cells derived from precursors within the double negative compartment.: Immunol Cell Biol. 1995 Feb;73(1):33-7. Unique Identifier : AIDSLINE MED/95286201; Fujimiya Y; Nakayama M; Shibata T; Abe J; Shimada M; Kohsaka T; Division of Immunology, National Children's Medical Research; Center, Tokyo, Japan.; Flow cytometric analysis demonstrated that fresh human thymocytes contain only a low level of mature CD8+ TCR alpha beta + or CD8+ TCR gamma delta + cells and they consist consist of approximately 70% double positive (DP) and approximately 10% double negative (DN) cells. These unfractionated thymocytes could be select
Development of a natural-habitat breeding facility for nonhuman primates.: J Am Vet Med Assoc. 1995 Feb 15;206(4):469-75. Unique Identifier : AIDSLINE MED/95286372; Morton WR; Kyes RC; Kyes KB; Knitter GH; Sajuthi D; Iskandriati D; Pamungkas J; Regional Primate Research Center, University of Washington,; Seattle 98195, USA.
Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis.: J Antimicrob Chemother. 1995 Jan;35(1):103-14. Unique Identifier : AIDSLINE MED/95286440; Johnson EM; Warnock DW; Luker J; Porter SR; Scully C; PHLS Mycology Reference Laboratory, Public Health Laboratory,; Bristol, UK.; We examined the effect of different fluconazole treatment regimens on the emergence of azole drug resistance among Candida species recovered from the mouths of 54 HIV-infected individuals. Patients were assigned to one of three treatment groups depending on their history of oral candidosis and fluconazole use. Mouthwa
Real-time analysis of the transcriptional regulation of HIV and hCMV promoters in single mammalian cells.: J Cell Sci. 1995 Feb;108 ( Pt 2):441-55. Unique Identifier : AIDSLINE MED/95286692; White MR; Masuko M; Amet L; Elliott G; Braddock M; Kingsman AJ; Kingsman SM; Amersham International, Bucks, UK.; The regulation of human cytomegalovirus (hCMV) and human immunodeficiency virus (HIV) gene expression has been studied in single intact mammalian cells. Viral promoters were placed upstream of the firefly luciferase reporter gene and the resulting hybrid reporter constructs were st
An assay for HIV infection of cultured human cervix-derived cells.: J Virol Methods. 1995 Mar;52(1-2):1-13. Unique Identifier : AIDSLINE MED/95286730; Phillips DM; Tan X; Pearce-Pratt R; Zacharopoulos VR; Population Council, New York, NY 10021, USA.; There is a critical need to develop new strategies to prevent sexual transmission of HIV. Condoms have limited acceptance, and a vaccine may not be available for many years. A vaginal formulation could provide an alternative method if a compound that inhibits sexual transmission of HIV can be identified or synthesized
Detection of HIV-1 RNA in plasma and serum samples using the NASBA amplification system compared to RNA-PCR.: J Virol Methods. 1995 Mar;52(1-2):121-32. Unique Identifier : AIDSLINE MED/95286733; Vandamme AM; Van Dooren S; Kok W; Goubau P; Fransen K; Kievits T; Schmit JC; De Clercq E; Desmyter J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; The presence of HIV-1 RNA in the plasma and serum of European and African patients was monitored using RNA-polymerase chain reaction (RNA-PCR) and the new isothermal NASBA nucleic acid amplification system encompassing a gel-based detection assay (ELGA). Identical RNA extraction procedures, provided by the NASBA ampli
Detection of HIV-1 RNA in plasma by isothermal amplification (NASBA) irrespective of the stage of HIV-1 infection.: J Virol Methods. 1995 Mar;52(1-2):175-81. Unique Identifier : AIDSLINE MED/95286739; Zaaijer HL; Kok W; ten Veen JH; Reesink HW; Foolen H; Winkel IN; Huisman JG; Cuypers HT; Kievits T; Lelie PN; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service (CLB), Amsterdam.; Using an experimental assay for isothermal amplification of HIV RNA in plasma (NASBA, Organon Teknika, Boxtel, The Netherlands ), 70 samples from 59 HIV-1-infected persons and 29 samples from 28 uninfected volunteer blood donors were tested for the presence of HIV-1 RNA. The HI
Analysis and genotyping of PCR products of the Amplicor HIV-1 kit.: J Virol Methods. 1995 Mar;52(1-2):65-74. Unique Identifier : AIDSLINE GENBANK/Z33480; Barlow KL; Tosswill JH; Clewley JP; Hepatitis and Retrovirus Laboratory, Central Public Health; Laboratory, London, UK.; The Roche Amplicor PCR kit was used to detect HIV-1 DNA in UK patients of known serostatus. Four false-negative and/or equivocal results were obtained from patients who were known to be anti HIV seropositive (Tosswill et al., 1994). Cells from the blood of these patients were shown to contain HIV DNA after extraction,
The detection of HIV-1 proviral DNA by PCR in clotted blood specimens.: J Virol Methods. 1995 Mar;52(1-2):87-94. Unique Identifier : AIDSLINE MED/95286752; Boriskin YuS; Booth JC; Fernando S; Carrington D; Evans MR; Hay P; Coates AR; Department of Medical Microbiology, St George's Hospital Medical; School, London, UK.; Six hundred and ninety-two specimens, each consisting of a suspension of the residual free cells in samples of clotted blood (but not the clots themselves) from 680 patients at high risk for exposure to human immunodeficiency virus (HIV), were tested by a nested polymerase chain reaction (PCR) procedure which had been
Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat.: J Clin Invest. 1995 Jun;95(6):2587-93. Unique Identifier : AIDSLINE MED/95286822; Theus SA; Andrews RP; Steele P; Walzer PD; Research Service, Veterans Affairs Medical Center, Cincinnati, OH; 45220, USA.; Pneumocystis carinii is a major opportunistic pathogen and a leading cause of morbidity in patients with AIDS. CD4+ cells have been shown to be important in host defenses against P. carinii, but the antigen(s) involved with this response have not been identified. We undertook the present study to determine whether the
Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.: J Clin Invest. 1995 Jun;95(6):2711-9. Unique Identifier : AIDSLINE MED/95286835; Balashov KE; Khoury SJ; Hafler DA; Weiner HL; Center for Neurologic Diseases, Brigham and Women's Hospital,; Harvard Medical School, Boston, Massachusetts 02115, USA.; The autologous mixed lymphocyte reaction (AMLR) involves the activation of T cells by autologous antigen presenting cells. Cells are generated during the course of the AMLR that have suppressive properties in vitro. In the present study we investigated the induction of CD8+ T cells in the AMLR with suppressive propert
Association between maternal antibodies to the external envelope glycoprotein and vertical transmission of human T-lymphotropic virus type I. Maternal anti-env antibodies correlate with protection in non-breast-fed children.: J Clin Invest. 1995 Jun;95(6):2920-5. Unique Identifier : AIDSLINE MED/95286861; Hino S; Katamine S; Miyamoto T; Doi H; Tsuji Y; Yamabe T; Kaplan JE; Rudolph DL; Lal RB; Department of Virology, Faculty of Medicine, Tottori University,; Yonago, Japan.; Vertical transmission of human T-lymphotropic virus type I (HTLV-I) depends primarily on breast-feeding; substitution of bottle-feeding has reduced the transmission rate from 20% in breast-fed children to 3% among bottle-fed. To determine the correlates of transmission for long breast-feeding (> or = 6 mo), short brea
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice.: J Clin Invest. 1995 Jun;95(6):2979-85. Unique Identifier : AIDSLINE MED/95286868; Healey D; Ozegbe P; Arden S; Chandler P; Hutton J; Cooke A; Department of Pathology, Cambridge University, United Kingdom.; CD4+ T cell lines were generated from the spleens of diabetic NOD mice against crude membrane preparations derived from a rat insulinoma. Adoptive transfer of these lines into neonatal mice confirms that overt diabetes is induced by gamma-IFN-secreting Th1 cells, whereas transfer of IL-4-secreting Th2 cells resulted i
Some unorthodox views and a selection hypothesis on the origin of the AIDS viruses.: J Hist Med Allied Sci. 1995 Apr;50(2):253-73. Unique Identifier : AIDSLINE MED/95286975; Grmek MD
A modified ELISA and western blot accurately determine anti-human immunodeficiency virus type 1 antibodies in oral fluids obtained with a special collecting device.: J Infect Dis. 1995 Jun;171(6):1406-10. Unique Identifier : AIDSLINE MED/95287029; Emmons WW; Paparello SF; Decker CF; Sheffield JM; Lowe-Bey FH; HIV Evaluation Unit, National Naval Medical Center, Bethesda,; Maryland, USA.; Serum and saliva from 195 known human immunodeficiency virus (HIV)-seropositive patients and 198 military personnel undergoing annual HIV serologic testing were evaluated in a prospective, blinded fashion for anti-HIV-1 antibodies. Oral specimens, collected with a device designed to concentrate oral mucosal transudate
Establishment and characterization of human immunodeficiency virus type 1 (HIV-1) envelope-specific CD4+ T lymphocyte lines from HIV-1-seropositive patients.: J Infect Dis. 1995 Jun;171(6):1420-30. Unique Identifier : AIDSLINE MED/95287031; Ratto S; Sitz KV; Scherer AM; Manca F; Loomis LD; Cox JH; Redfield RR; Birx DL; Henry M. Jackson Foundation, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; Human immunodeficiency virus type 1 (HIV-1) gp160-, gp120-, and tetanus toxoid-specific CD4+ T lymphocyte lines were developed from 11 HIV-1-seropositive volunteers enrolled in a vaccine therapy trial. Of the 20 HIV-1 envelope-specific T cell lines, 9 were challenged with a panel of overlapping peptides spanning the g
Pharmacokinetic, safety, and antiviral profiles of oral ganciclovir in persons infected with human immunodeficiency virus: a phase I/II study. AIDS Clinical Trials Group, and Cytomegalovirus Cooperative Study Group.: J Infect Dis. 1995 Jun;171(6):1431-7. Unique Identifier : AIDSLINE MED/95287032; Spector SA; Busch DF; Follansbee S; Squires K; Lalezari JP; Jacobson MA; Connor JD; Jung D; Shadman A; Mastre B; et al; Dept. of Pediatrics, University of California, San Diego, La; Jolla 92093-0672, USA.; A phase I/II study evaluated the pharmacokinetics, tolerability, and antiviral activity of oral ganciclovir in persons infected with human immunodeficiency virus (HIV). Oral bioavailability ranged from 2.6% to 7.3%. The mean maximum serum concentration achieved at 1000 mg every 8 h was 1.11 micrograms/mL, and mean tro
A phase I/II study of 2'-deoxy-3'-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection.: J Infect Dis. 1995 Jun;171(6):1438-47. Unique Identifier : AIDSLINE MED/95287033; Pluda JM; Cooley TP; Montaner JS; Shay LE; Reinhalter NE; Warthan SN; Ruedy J; Hirst HM; Vicary CA; Quinn JB; et al; Medicine Branch, National Cancer Institute, Bethesda, MD 20852,; USA.; In a phase I/II trial assessing the toxicity, pharmacokinetics, and activity of the (-)enantiomer of 2 -deoxy-3 -thiacytidine ( 3TC , lamivudine), 97 patients with AIDS or advanced human immunodeficiency virus (HIV) disease were administered 3TC at 0.5-
Dependency of antibody titer on provirus load in human T lymphotropic virus type I carriers: an interpretation for the minor population of seronegative carriers.: J Infect Dis. 1995 Jun;171(6):1455-60. Unique Identifier : AIDSLINE MED/95287035; Miyata H; Kamahora T; Iha S; Katamine S; Miyamoto T; Hino S; Department of Virology, Faculty of Medicine, Tottori University,; Yonago, Japan.; To evaluate the prevalence of seronegative carriers of human T lymphotropic virus type I (HTLV-I), buffy coat samples from 1015 Okinawan high school students were tested by immunoassays and nested polymerase chain reaction (PCR). Among 17 HTLV-I carriers, 1 person who was seronegative and 1 who was PCR-negative were i
Antigenic variation by positional control of major surface glycoprotein gene expression in Pneumocystis carinii.: J Infect Dis. 1995 Jun;171(6):1563-8. Unique Identifier : AIDSLINE MED/95287050; Wada M; Sunkin SM; Stringer JR; Nakamura Y; Department of Tumor Biology, University of Tokyo, Japan.; Major cell surface glycoproteins (MSGs) of Pneumocystis carinii play a crucial role in host-parasite interactions during P. carinii pneumocystosis in AIDS patients. Genes encoding MSGs are repeated and dispersed throughout the genome and are highly polymorphic. MSG gene expression was found to be mediated by a DNA ele
Ganciclovir therapy for cytomegalovirus (CMV) infection of the central nervous system in AIDS patients: monitoring by CMV DNA detection in cerebrospinal fluid.: J Infect Dis. 1995 Jun;171(6):1603-6. Unique Identifier : AIDSLINE MED/95287057; Cinque P; Baldanti F; Vago L; Terreni MR; Lillo F; Furione M; Castagna A; Monforte AD; Lazzarin A; Linde A; Department of Infectious Diseases, IRCCS Ospedale San Raffaele,; Milan, Italy.; Seven AIDS patients with central nervous system (CNS) disease and cytomegalovirus ( CMV ) DNA in cerebrospinal fluid (CSF) were evaluated before and 3 weeks after standard ganciclovir treatment by nested polymerase chain reacti
Frequent use of menfegol spermicidal vaginal foaming tablets associated with a high incidence of genital lesions.: J Infect Dis. 1995 Jun;171(6):1611-4. Unique Identifier : AIDSLINE MED/95287059; Goeman J; Ndoye I; Sakho LM; Mboup S; Piot P; Karam M; Belsey E; Lange JM; Laga M; Perriens JH; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; Menfegol is a spermicide with in vitro activity against human immunodeficiency virus (HIV). A randomized placebo-controlled safety study covered the use of menfegol foaming tablets for 14 days at increasing frequencies of insertion by 125 prostitutes in Dakar, Senegal . The frequen
Human immunodeficiency virus type 1 p24 antigen in cervicovaginal secretions.: J Infect Dis. 1995 Jun;171(6):1615-8. Unique Identifier : AIDSLINE MED/95287060; Belec L; Matta M; Payan C; Gresenguet G; Tevi-Benissan C; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.; The failure to detect human immunodeficiency virus (HIV) antigen in cervicovaginal secretions (CVS) from HIV-infected women could be due in part to an in situ formation of immune complexes involving HIV antigens and cervicovaginal anti-HIV antibodies. CVS from 30 HIV-1-infected heterosexual women were assayed for p24
Single-strand conformation polymorphism study of human immunodeficiency virus type 1 RNA and DNA in plasma, peripheral blood mononuclear cells, and their virologic cultures.: J Infect Dis. 1995 Jun;171(6):1619-22. Unique Identifier : AIDSLINE MED/95287061; Lin HJ; Siwak EB; Lauder IJ; Hollinger FB; Division of Molecular Virology, Baylor College of Medicine,; Houston, TX 77030, USA.; Single-strand conformation polymorphism (SSCP) analysis was applied to human immunodeficiency virus type 1 (HIV-1) nucleic acids in plasma and peripheral blood mononuclear cells (PBMC) from 16 patients and to 15 PBMC cocultures and 6 plasma cultures prepared from the specimens. Two hypervariable regions were analyzed:
Induction of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T lymphocyte responses in seronegative adults by a nonreplicating, host-range-restricted canarypox vector (ALVAC) carrying the HIV-1MN env gene.: J Infect Dis. 1995 Jun;171(6):1623-7. Unique Identifier : AIDSLINE MED/95287062; Egan MA; Pavlat WA; Tartaglia J; Paoletti E; Weinhold KJ; Clements ML; Siliciano RF; Department of Medicine, School of Medicine, Johns Hopkins; University, Baltimore, Maryland 21205, USA.; CD8+ cytolytic T lymphocytes (CTL) are likely to be an important component of effective vaccines against human immunodeficiency virus type 1 (HIV-1). CTL can be induced most effectively with live virus vectors. However, because of concerns about the safety of such vectors, a nonreplicating canarypox vector (ALVAC) cap
High-dose pentoxifylline in patients with AIDS: inhibition of tumor necrosis factor production. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group.: J Infect Dis. 1995 Jun;171(6):1628-32. Unique Identifier : AIDSLINE MED/95287063; Dezube BJ; Lederman MM; Spritzler JG; Chapman B; Korvick JA; Flexner C; Dando S; Mattiacci MR; Ahlers CM; Zhang L; et al; Department of Medicine, Beth Israel Hospital, Boston, MA 02215,; USA.; Tumor necrosis factor-alpha (TNF) may activate human immunodeficiency virus (HIV), antagonize zidovudine activity, and contribute to AIDS wasting syndrome. Pentoxifylline decreases TNF production. In cell culture, pentoxifylline decreases HIV replication and gene expression. Since an AIDS Clinical Trial Group study su
Efficacy and toxicity of two doses of trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus. Dutch AIDS Treatment Group.: J Infect Dis. 1995 Jun;171(6):1632-6. Unique Identifier : AIDSLINE MED/95287064; Schneider MM; Nielsen TL; Nelsing S; Hoepelman AI; Eeftinck Schattenkerk JK; van der Graaf Y; Kolsters AF; Borleffs JC; Department of Internal Medicine (Section of Immunology and; Infectious Diseases), University Hospital Utrecht, Netherlands.; The efficacy and toxicity of trimethoprim-sulfamethoxazole (TMP-SMZ) as primary prophylaxis against Pneumocystis carinii pneumonia (PCP) for patients with human immunodeficiency virus (HIV) infection was assessed by comparing the effects of two dosages (480 or 960 mg once a day) of the drug. The multicenter trial invo
HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea.: J Infect Dis. 1995 Jun;171(6):1636-9. Unique Identifier : AIDSLINE MED/95287065; Mathewson JJ; Jiang ZD; Zumla A; Chintu C; Luo N; Calamari SR; Genta RM; Steephen A; Schwartz P; DuPont HL; Center for Infectious Diseases, University of Texas Medical; School/School of Public Health, Houston 77030, USA.; Diarrhea occurs commonly in African human immunodeficiency virus (HIV) infections. A case-control (HIV-positive vs. -negative) study of adults with diarrhea was done in Lusaka, Zambia , to determine the prevalence of intestinal infection by HEp-2 cell-adherent Escherichia coli. Adhe
Consideration of the prevalence of cytomegalovirus retinitis significantly alters the assessment of a serum cytomegalovirus DNA test [letter; comment]: J Infect Dis. 1995 Jun;171(6):1688-90. Unique Identifier : AIDSLINE MED/95287079; Hendrix CW
Tuberculous pancreatic abscess: an unusual manifestation of HIV infection.: J R Soc Med. 1995 Feb;88(2):109P-110P. Unique Identifier : AIDSLINE MED/95287366; Desmond NM; Kingdon E; Beale TJ; Coker RJ; Tanner AG; Harris JW; Department of Genitourinary Medicine, St Mary's Hospital, London,; UK.; Pancreatic tuberculosis is unusual occurring in only 2.7% of autopsy studies of persons with miliary disease. Reports of focal pancreatic tuberculosis are rare, even in patients with the acquired immunodeficiency syndrome (AIDS) in whom abdominal tuberculosis is a frequent feature. We describe two patients infected wi
Radiologic findings in two AIDS patients with Rhodococcus equi pneumonia.: J Thorac Imaging. 1995 Spring;10(2):121-5. Unique Identifier : AIDSLINE MED/95287414; Mayor B; Jolidon RM; Wicky S; Giron J; Schnyder P; Department of Radiology, University Hospital, Lausanne,; Switzerland.; Rhodococcus equi (R. equi) has been reported as an occasional cause of pulmonary infection in severely immunocompromised hosts, including AIDS patients. Our purpose is to describe the radiologic findings in two AIDS patients with R. equi pneumonia. Chest radiographs showed right-upper-lobe consolidation and cavitation
Bronchogenic carcinoma in 13 patients infected with the human immunodeficiency virus (HIV): clinical and radiographic findings.: J Thorac Imaging. 1995 Spring;10(2):99-105. Unique Identifier : AIDSLINE MED/95287426; Gruden JF; Webb WR; Yao DC; Klein JS; Sandhu JS; Department of Radiology, San Francisco General Hospital, CA; 94110, USA.; Bronchogenic carcinoma is a cause of parenchymal or hilar masses with or without mediastinal adenopathy in HIV-seropositive smokers. Lung cancer can occur earlier than the more commonly recognized opportunistic infections and in patients not known to be HIV seropositive. Tumor cell types do not differ markedly from th
Inhibition of clinical human immunodeficiency virus (HIV) type 1 isolates in primary CD4+ T lymphocytes by retroviral vectors expressing anti-HIV genes.: J Virol. 1995 Jul;69(7):4045-52. Unique Identifier : AIDSLINE MED/95287453; Vandendriessche T; Chuah MK; Chiang L; Chang HK; Ensoli B; Morgan RA; Clinical Gene Therapy Branch, National Cancer Institute,; Bethesda, Maryland 20892, USA.; Gene therapy may be of benefit in human immunodeficiency virus type 1 (HIV-1)-infected individuals by virtue of its ability to inhibit virus replication and prevent viral gene expression. It is not known whether anti-HIV-1 gene therapy strategies based on antisense or transdominant HIV-1 mutant proteins can inhibit th
Incorporation of pseudorabies virus gD into human immunodeficiency virus type 1 Gag particles produced in baculovirus-infected cells.: J Virol. 1995 Jul;69(7):4060-8. Unique Identifier : AIDSLINE MED/95287455; Garnier L; Ravallec M; Blanchard P; Chaabihi H; Bossy JP; Devauchelle G; Jestin A; Cerutti M; Laboratorie de Pathologie Comparee, Centre National de la; Recherche Scientifique UA 1184, France.; The human immunodeficiency virus type 1 (HIV-1) Pr55gag precursors were previously shown to assemble and bud efficiently as noninfectious virus-like particles (VLPs) when expressed in baculovirus-infected insect cells. In this study, we examined the abilities of foreign antigens to be incorporated on the outer surface
The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cells.: J Virol. 1995 Jul;69(7):4069-78. Unique Identifier : AIDSLINE MED/95287456; Huang M; Takac M; Kozak CA; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.; In susceptible mice, the murine AIDS (MAIDS) defective virus can induce marked expansion of its target cells, the majority of which belong to the B-cell lineage. This expansion, which appears to be critical for the development of the immunodeficiency syndrome, is initially polyclonal but becomes oligoclonal late in th
Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance.: J Virol. 1995 Jul;69(7):4086-94. Unique Identifier : AIDSLINE MED/95287458; Luukkonen BG; Tan W; Schwartz S; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.; In this study, we examined the mechanism of translation of the human immunodeficiency virus type 1 tat mRNA in eucaryotic cells. This mRNA contains the tat open reading frame (ORF), followed by rev and nef ORFs, but only the first ORF, encoding tat, is efficiently translated. Introduction of premature stop codons in t
Membrane permeabilization by different regions of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41.: J Virol. 1995 Jul;69(7):4095-102. Unique Identifier : AIDSLINE MED/95287459; Arroyo J; Boceta M; Gonzalez ME; Michel M; Carrasco L; Centro Nacional de Biotecnologia, Universidad Autonoma, Madrid,; Spain.; The transmembrane glycoprotein (gp41) of human immunodeficiency virus type 1 (HIV-1) has been implicated in the cytopathology observed during HIV infection. The first amino acids located at the amino terminus are involved in membrane fusion and syncytium formation, while sequences located at the carboxy terminus have
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.: J Virol. 1995 Jul;69(7):4112-21. Unique Identifier : AIDSLINE MED/95287461; Goldsmith MA; Warmerdam MT; Atchison RE; Miller MD; Greene WC; Gladstone Institute of Virology and Immunology, School of; Medicine, University of California San Francisco 94141, USA.; Recent evidence indicates that the nef gene of human immunodeficiency virus type 1 augments rather than inhibits viral replication in both cell culture and in vivo models. In addition, nef alters various normal cellular processes, including the display of CD4 on the cell surface. However, it remains unknown whether th
Influence of transmembrane domains on the fusogenic abilities of human and murine leukemia retrovirus envelopes.: J Virol. 1995 Jul;69(7):4149-57. Unique Identifier : AIDSLINE MED/95287466; Denesvre C; Sonigo P; Corbin A; Ellerbrok H; Sitbon M; Institut Cochin de Genetique Moleculaire, CNRS UPR415,; Universite Paris V, France.; The envelopes of two highly divergent oncoviruses, human T-cell leukemia virus type 1 (HTLV-1) and Friend murine leukemia virus (F-MuLV), have distinct patterns of cellular receptor recognition, fusion, and syncytium formation. To analyze the influence of the transmembrane envelope subunit (TM) on fusogenic properties
Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes.: J Virol. 1995 Jul;69(7):4166-72. Unique Identifier : AIDSLINE MED/95287468; Simon JH; Southerling TE; Peterson JC; Meyer BE; Malim MH; Howard Hughes Medical Institute, University of Pennsylvania; School of Medicine, Philadelphia 19104-6148, USA.; The productive infection of many susceptible human cells, including lymphocytes and macrophages derived from peripheral blood, by the pathogenic lentivirus human immunodeficiency virus type 1 requires expression of the virally encoded vif (for virion infectivity factor) gene. Interestingly, this gene appears to have b
Effects of exogenous, nonleukemogenic, ecotropic murine leukemia virus infections on the immune systems of adult C57BL/6 mice.: J Virol. 1995 Jul;69(7):4182-8. Unique Identifier : AIDSLINE MED/95287470; Lee JS; Giese NA; Elkins KL; Yetter RA; Holmes KL; Hartley JW; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.; Mouse AIDS (MAIDS) develops in mice infected with a mixture of replication-competent ecotropic and mink lung cell focus-inducing murine leukemia viruses and an etiologic replication-defective virus. Helper viruses are not required for induction of MAIDS, but the time course of disease is accelerated in their presence.
Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques.: J Virol. 1995 Jul;69(7):4198-205. Unique Identifier : AIDSLINE MED/95287472; Marthas ML; van Rompay KK; Otsyula M; Miller CJ; Canfield DR; Pedersen NC; McChesney MB; California Regional Primate Research Center, University of; California, Davis 95616, USA.; To evaluate how viral variants may affect disease progression in human pediatric AIDS, we studied the potential of three simian immunodeficiency virus (SIV) isolates to induce simian AIDS in newborn rhesus macaques. The three virus isolates were previously shown to range from pathogenic (SIVmac251 and SIVmac239) to no
Genetic analysis of the major homology region of the Rous sarcoma virus Gag protein.: J Virol. 1995 Jul;69(7):4213-27. Unique Identifier : AIDSLINE MED/95287474; Craven RC; Leure-duPree AE; Weldon RA Jr; Wills JW; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033, USA.; The mature cores of all retroviruses contain a major structural protein known as the CA (capsid) protein. Although it appears to form a shell around the ribonucleoprotein complex that contains the viral RNA, its function in viral replication is largely unknown. Little sequence similarity exists between the CA proteins
Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus.: J Virol. 1995 Jul;69(7):4228-36. Unique Identifier : AIDSLINE +; Michael NL; Chang G; d'Arcy LA; Ehrenberg PK; Mariani R; Busch MP; Birx DL; Schwartz DH; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; We have been studying a patient who acquired human immunodeficiency virus (HIV) infection via a blood transfusion 13 years ago. She has remained asymptomatic since that time. The blood donor and two other recipients have all died of AIDS. Although this patient has shown persistently strong seroreactivity to HIV type 1
Identification and characterization of the viral interaction determinant of the subgroup A avian leukosis virus receptor.: J Virol. 1995 Jul;69(7):4261-6. Unique Identifier : AIDSLINE MED/95287479; Zingler K; Belanger Ca; Peters R; Agard E; Young JA; Gladstone Institute of Virology and Immunology, University of; California School of Medicine, San Francisco 94141-9100, USA.; The cellular receptor for subgroup A avian leukosis viruses (ALV-A) has a small, 83-amino-acid extracellular domain containing a motif that is related in sequence to the ligand binding repeats of the low-density lipoprotein receptor. Extensive mutagenesis of the ALV-A receptor has identified two acidic amino acids (As
Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies.: J Virol. 1995 Jul;69(7):4267-73. Unique Identifier : AIDSLINE MED/95287480; Burkly L; Mulrey N; Blumenthal R; Dimitrov DS; Biogen Inc, Cambridge, Massachusetts 02142, USA.; Antibodies to several epitopes of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120-gp41) can synergize in inhibiting HIV-1 infection. In the present study we tested the ability of a monoclonal antibody (MAb), 5A8, which interacts with CD4 domain 2, and other CD4-specific MAbs to synergize w
Evidence that measles virus hemagglutinin initiates modulation of leukocyte function-associated antigen 1 expression.: J Virol. 1995 Jul;69(7):4357-63. Unique Identifier : AIDSLINE MED/95287491; Nagendra AR; Smith CW; Wyde PR; Department of Microbiology and Immunology, Baylor College of; Medicine, Houston, Texas 77030, USA.; Measles virus (MV), human immunodeficiency virus, Epstein-Barr virus, and other leukotropic viruses can modulate the expression of leukocyte function antigen 1 (LFA-1) on the surface of infected and nearby leukocytes. This ability to induce changes in LFA-1 expression may play an important role in the pathogenesis of
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.: J Virol. 1995 Jul;69(7):4413-22. Unique Identifier : AIDSLINE MED/95287498; Sullivan N; Sun Y; Li J; Hofmann W; Sodroski J; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115, USA.; The structure, replicative properties, and sensitivity to neutralization by soluble CD4 and monoclonal antibodies were examined for molecularly cloned envelope glycoproteins derived from human immunodeficiency virus type 1 (HIV-1) viruses either isolated directly from patients or passaged in T-cell lines. Complementat
Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo.: J Virol. 1995 Jul;69(7):4453-62. Unique Identifier : AIDSLINE MED/95287502; Shibata R; Hoggan MD; Broscius C; Englund G; Theodore TS; Buckler-White A; Arthur LO; Israel Z; Schultz A; Lane HC; et al; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892-0460, USA.; Fresh human immunodeficiency virus type 1 (HIV-1) isolates from patients with AIDS were screened for infectivity in chimpanzee peripheral blood mononuclear cells (PBMC) to identify strains potentially able to generate high virus loads in an inoculated animal. Only 3 of 23 isolates obtained were infectious in chimpanze
A molecular determinant of human immunodeficiency virus particle assembly located in matrix antigen p17.: J Virol. 1995 Jul;69(7):4519-23. Unique Identifier : AIDSLINE MED/95287512; Morikawa Y; Kishi T; Zhang WH; Nermut MV; Hockley DJ; Jones IM; Kitasato Institute, Kitasato University, Tokyo, Japan.; We report single-point mutations that are located in the matrix protein domain of the gag gene of human immunodeficiency virus type 1 and that prevent Gag particle formation. We show that mutations of p17 that abolish human immunodeficiency virus particle assembly also prevent the dimerization of p17 protein, as measu
Monocyte-derived cultured dendritic cells are susceptible to human immunodeficiency virus infection and transmit virus to resting T cells in the process of nominal antigen presentation.: J Virol. 1995 Jul;69(7):4544-7. Unique Identifier : AIDSLINE MED/95287517; Tsunetsugu-Yokota Y; Akagawa K; Kimoto H; Suzuki K; Iwasaki M; Yasuda S; Hausser G; Hultgren C; Meyerhans A; Takemori T; Department of Immunology, National Institute of Health and AIDS; Research Center, Tokyo, Japan.; The susceptibility of monocyte-derived cultured dendritic cells (DCs) to human immunodeficiency virus (HIV) infection and their role in viral transmission in the immune response were studied in detail. We observed that highly purified cultured DCs were infected with the T-tropic Lai strain of HIV type 1 (HIV-1Lai) via
Prior infection with a nonpathogenic chimeric simian-human immunodeficiency virus does not efficiently protect macaques against challenge with simian immunodeficiency virus.: J Virol. 1995 Jul;69(7):4569-71. Unique Identifier : AIDSLINE MED/95287522; Letvin NL; Li J; Halloran M; Cranage MP; Rud EW; Sodroski J; Harvard Medical School, Beth Israel Hospital, Boston,; Massachusetts 02215, USA.; Prior infection with a nef-deleted simian immunodeficiency virus (SIV) protects macaques not only against a homologous pathogenic SIV challenge but also against challenge with a chimeric SIV expressing a human immunodeficiency virus type 1 env gene (SHIV). Since this SHIV is itself nonpathogenic, we sought to explore
Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes.: J Virol. 1995 Jul;69(7):4582-6. Unique Identifier : AIDSLINE MED/95287525; Simm M; Shahabuddin M; Chao W; Allan JS; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center and College of Physicians & Surgeons, Columbia University,; New York, New York 10019, USA.; Productive, spreading infection of peripheral blood lymphocytes (PBL) with human immunodeficiency virus type 1 (HIV-1) requires the viral protein Vif. To study the requirement for vif in this system, we infected PBL with a phenotypically complemented HIV-1 clone mutated in vif. Progeny virus was produced which was non
Use of a novel human immunodeficiency virus type 1 reporter virus expressing human placental alkaline phosphatase to detect an alternative viral receptor.: J Virol. 1995 Jul;69(7):4587-92. Unique Identifier : AIDSLINE MED/95287526; He J; Landau NR; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; We report here on the construction and use of a novel human immunodeficiency virus (HIV) type 1 reporter vector, HIV-AP, that encodes human placental alkaline phosphatase. Upon staining with chromogenic alkaline phosphatase substrates 24 to 36 h postinfection, cells infected with HIV-AP develop an intense purple color
Outcome of patients with HIV infection and decreased consciousness or recurrent seizures [letter; comment]: JAMA. 1995 Jun 14;273(22):1738. Unique Identifier : AIDSLINE MED/95287558; Redosh DJ
HIV Pathogenesis. Keystone symposium. Keystone, Colorado, April 17-23, 1995. Abstracts.: J Cell Biochem Suppl. 1995;21B:179-247. Unique Identifier : AIDSLINE MED/95287625
Sexually Transmitted Diseases in the HIV Era. Keystone symposium. Keystone, Colorado, April 17-23, 1995. Abstracts.: J Cell Biochem Suppl. 1995;21B:249-59. Unique Identifier : AIDSLINE MED/95287626
HSP70 production and inhibition of cell proliferation in Molt-4 T-cells after cell-to-cell transmission of HTLV-I: effect of PGA1.: Leuk Res. 1995 May;19(5):345-56. Unique Identifier : AIDSLINE MED/95287634; D'Onofrio C; Puglianiello A; Amici C; Faraoni I; Lanzilli G; Bonmassar E; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.; Infection with HTLV-I is associated with leukemic transformation of mature CD4+ T lymphocytes. PGA1, a powerful inhibitor of tumour cell proliferation, can prevent the clonal expansion of HTLV-I-infected cells following acute infection of cord blood-derived mononuclear cells. Since the antiproliferative effect of PGA1
Response to interferon-alpha in patients with hairy cell leukemia relapsing after treatment with 2-chlorodeoxyadenosine.: Leukemia. 1995 May;9(5):929-32. Unique Identifier : AIDSLINE MED/95287665; Seymour JF; Estey EH; Keating MJ; Kurzrock R; Department of Clinical Haematology and Medical Oncology, Royal; Melbourne Hospital, Australia.; 2-Chlorodeoxyadenosine (2-CdA) has recently established itself as an extremely effective therapy for patients with hairy cell leukemia. To date, the issue of how to treat patients relapsing after 2-CdA has not been adequately addressed. In our initial study, 41 of 46 patients achieved an objective response (complete o
[The calculation of AIDS costs in Spain by simulation technics (see comments)]: Med Clin (Barc). 1995 Apr 22;104(15):568-72. Unique Identifier : AIDSLINE MED/95287671; Antonanzas Villar F; Anton Botella F; Juarez Castello C; Departamento de Economia y Empresa, Universidad de La Rioja,; Logrono.; BACKGROUND: The aim of this study was to elaborate a quantitative model integrating the clinical, and epidemiologic characteristics of the economic costs of the treatment of HIV infected and AIDS patients in Spain to determine the future evolution of the treatment of HIV infected an
[How much does AIDS cost us? (editorial; comment)]: Med Clin (Barc). 1995 Apr 22;104(15):573-5. Unique Identifier : AIDSLINE MED/95287672; Cabases Hita JM
[Acute pancreatitis due to antimonials in patients with visceral leishmaniasis and HIV infection]: Med Clin (Barc). 1995 Apr 22;104(15):578-80. Unique Identifier : AIDSLINE MED/95287674; Cortes E; Ribera E; Cucurull E; de Otero J; Ocana I; Pahissa A; Servicio de Medicina Interna, Hospital General Universitario Vall; d'Hebron, Universidad Autonoma, Barcelona.; Acute pancreatitis is an adverse effect of the treatment with antimonial drugs which is infrequently described in patients with HIV infection and visceral leishmaniasis (VL). Twenty-two percent of the patients having this treatment had acute pancreatitis (7 cases) in the authors center. In all the cases, severe immun
[The HIV test: a review of policies and a proposal for accomplishing anonymous unreported screening in Spain]: Med Clin (Barc). 1995 Apr 22;104(15):591-5. Unique Identifier : AIDSLINE MED/95287677; Estebanez P; Fitch K; Cifuentes I; Health Promotion Sciences Unit, London School of Hygiene and; Tropical Medicine, Reino Unido.
[HIV infection and leishmaniasis (letter; comment)]: Med Clin (Barc). 1995 Apr 22;104(15):597-8. Unique Identifier : AIDSLINE MED/95287680; Gonzalez Anglada MI; Pena y Sanchez de Rivera JM; Barbado Hernandez FJ; Gonzalez Garcia J
HIV testing for health care workers.: Lamp. 1994 Oct;51(9):12. Unique Identifier : AIDSLINE MED/95287700
New South Wales Nurses' Association policy on HIV/AIDS & related illnesses.: Lamp. 1994 Oct;51(9):12-3. Unique Identifier : AIDSLINE MED/95287701
Threat to US army research on AIDS [news]: Lancet. 1995 Jun 10;345(8963):1499. Unique Identifier : AIDSLINE MED/95287717; Rowe PM
The right not to know HIV-test results [letter; comment]: Lancet. 1995 Jun 10;345(8963):1506-7. Unique Identifier : AIDSLINE MED/95287724; Frerichs RR
The right not to know HIV-test results [letter; comment]: Lancet. 1995 Jun 10;345(8963):1507. Unique Identifier : AIDSLINE MED/95287725; Garay JE
The right not to know HIV-test results [letter; comment]: Lancet. 1995 Jun 10;345(8963):1507-8. Unique Identifier : AIDSLINE MED/95287726; Nahlen BL; ter Kuile MM; Richters JM; Oloo A; Phillips-Howard PA
The right not to know HIV-test results [letter; comment]: Lancet. 1995 Jun 10;345(8963):1508. Unique Identifier : AIDSLINE MED/95287727; Green J; Kentish J
Rifampicin-resistant Mycobacterium tuberculosis [letter] [see comments]: Lancet. 1995 Jun 10;345(8963):1513. Unique Identifier : AIDSLINE MED/95287739; Weltman AC; Righi SP; DiFerdinando GT Jr; Jovell RJ; Driscoll JR
Now that we can, should we? Investigating the wisdom of home HIV testing.: Md Med J. 1995 May;44(5):355-7. Unique Identifier : AIDSLINE MED/95287790; Beall DP; Whyte JJ; Johns Hopkins Hospital, Baltimore, Maryland, USA.
Torulopsis glabrata vaginitis.: Obstet Gynecol. 1995 Jun;85(6):993-8. Unique Identifier : AIDSLINE MED/95288092; Spinillo A; Capuzzo E; Egbe TO; Baltaro F; Nicola S; Piazzi G; Clinica Ostetrico-Ginecologica, IRCCS Policlinico San Matteo,; Universita di Pavia, Italy.; OBJECTIVE: To study the sociodemographic risk factors and clinical features of Torulopsis glabrata vaginal infection. METHODS: We evaluated the sociodemographic and clinical characteristics of 86 consecutive symptomatic women attending a vaginitis clinic and isolated T glabrata. Case patients were compared with a cont
World AIDS Day 1995 [news]: Occup Health (Lond). 1995 May;47(5):154. Unique Identifier : AIDSLINE MED/95288094
Differential receptive and expressive language functioning of children with symptomatic HIV disease and relation to CT scan brain abnormalities.: Pediatrics. 1995 Jan;95(1):112-9. Unique Identifier : AIDSLINE MED/95288107; Wolters PL; Brouwers P; Moss HA; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD, USA.; OBJECTIVES. To investigate the effect of HIV disease on the receptive and expressive language of children and the relationship between CT scan brain abnormalities and language functioning. METHODS. Thirty-six children (mean age, 5.5 years; range, 1 through 10 years; 75% vertical transmission; 58% classified as encepha
Comparison of HIV+ and HIV- adolescents: risk factors and psychosocial determinants [see comments]: Pediatrics. 1995 Jan;95(1):96-104. Unique Identifier : AIDSLINE MED/95288139; Hein K; Dell R; Futterman D; Rotheram-Borus MJ; Shaffer N; Adolescent AIDS Program, Bronx, New York, USA.; According to the World Health Organization , half of the 14 million people with human immunodeficiency virus (HIV) worldwide were infected between the ages of 15 and 24 years. However, details about HIV-positive (HIV+) youths risk-related behavior and social context have not been previ
Testament of friendship [interview by Tony Sheldon]: Nurs Times. 1995 May 10-16;91(19):14-5. Unique Identifier : AIDSLINE MED/95288155; Van der Weerd J
AIDS epidemic in Asia [news]: Nurs J India. 1994 Oct;85(10):239. Unique Identifier : AIDSLINE MED/95288171
ANA-TNAI HIV/AIDS continuing education project. First regional satellite workshop: a report.: Nurs J India. 1994 Jul;85(7):151-3, 160. Unique Identifier : AIDSLINE MED/95288174; Dhaulta JP
[Lesions of the conus medullaris and the cauda equina caused by cytomegalovirus in HIV infection. 7 cases]: Presse Med. 1995 Mar 18;24(11):527-30. Unique Identifier : AIDSLINE MED/95288213; Jacomet C; Lebrette MG; el Amrani M; Monfort L; Gozlan J; Girard PM; Rozenbaum W; Service des Maladies infectieuses et tropicales, Hopital; Rothschild, Paris.; OBJECTIVES: Neurologic infections caused by cytomegalovirus are common in patients with acquired immunodeficiency syndrome (AIDS). The prognosis is particularly severe when the infection is localized in the conus medullaris and/or the cauda equina. METHODS: Among the 861 patients w
[Diagnosis of colitis caused by cytomegalovirus infection in AIDS. Comparative value of total colonoscopy and rectosigmoidoscopy (apropos of 24 cases). AIDS GIT]: Presse Med. 1995 Mar 25;24(12):572-6. Unique Identifier : AIDSLINE MED/95288225; Combes R; Vallot T; Marche C; Pepin P; Bouchaud O; Verdon R; Longuet P; Mignon M; Rene E; CHU Bichat-Claude Bernard, Paris.; OBJECTIVES: To evaluate the respective diagnostic value of flexible rectosigmoidoscopy and colonoscopy in the cytomegalovirus colitis. METHODS: Twenty-four patients with AIDS were studied retrospectively. The entry criteria were: flexible rectosigmoidoscopy or colonoscopy, with 2 r
[Persistent diarrhea in HIV infected patients: role of Enterocytozoon bieneusi]: Presse Med. 1995 Apr 8;24(14):671-4. Unique Identifier : AIDSLINE MED/95288236; Bernard E; Carles M; Pradier C; Boissy C; Roger PM; Hebuterne X; Mondain V; Michiels JF; Le Fichoux Y; Dellamonica P; Service de Maladies infectieuses et tropicales, Hopital de; l'Archet, Nice.; OBJECTIVES: To determine the epidemiologic, clinical and aetiologic features of chronic diarrhoea in patients with human immunodeficiency virus (HIV) infection. METHODS: Between January 1992 and April 1993, all HIV positive patients with chronic diarrhoea were enrolled in a prospective study. There were 46 patients in
Confidentiality of HIV medical records.: Prog Cardiovasc Nurs. 1995 Winter;10(1):42-5. Unique Identifier : AIDSLINE MED/95288267; Byrd CM; Baulch M; University of San Francisco, USA.
Self-reported high-risk behavioral history of HIV positive prison inmates.: Psychol Rep. 1995 Feb;76(1):237-8. Unique Identifier : AIDSLINE MED/95288416; Templer DI; Walker S; Nevada Department of Prisons, USA.; 30 male HIV positive prison inmates tended to deny high-risk behavior for infection, most notably homosexuality. The public health implications are that the veracity of such denial should not be assumed.
Malignant liver tumors that mimic benign lesions: analysis of five distinct lesions.: Semin Diagn Pathol. 1995 Feb;12(1):64-76. Unique Identifier : AIDSLINE MED/95288531; Ferrell L; Department of Pathology, University of California, San Francisco; 94143,USA.; The diagnosis of malignant liver tumors has long been an important part of surgical pathology, but now with improved radiographic and biopsy techniques, the appropriate pathological identification and differentiation of malignant from benign liver lesions has become even more critical. This review discusses five examp
Intestinal disaccharidase activity in human immunodeficiency virus disease.: Scand J Gastroenterol. 1995 Mar;30(3):235-41. Unique Identifier : AIDSLINE MED/95288569; Lim SG; Menzies IS; Nukajam WS; Lee CA; Johnson MA; Pounder RE; University Dept. of Medicine, Haemophilia Centre, London, UK.; BACKGROUND: The relationship between disaccharidase activity, progression of human immunodeficiency virus (HIV) disease, and diarrhoea and weight loss was investigated. METHODS: Forty-six HIV-positive patients ingested a solution of lactose, palatinose, sucrose, and lactulose after 24 h of dietary exclusion and overni
Natural killer suppressor factors in sera from HIV-infected subjects.: Scand J Immunol. 1995 Jun;41(6):523-8. Unique Identifier : AIDSLINE MED/95288580; Goicoa MA; Sen L; Iannitelli PS; Diez RA; Estevez ME; Division Inmunologia Oncologica, Instituto de Investigaciones; Hematologicas Mariano R. Castex, Academia Nacional de Medicina,; Buenos Aires, Argentina.; We investigated the presence of NK suppressor factors in HIV+ sera. We further investigated if gp120 could be one of the substances responsible for the impairment of NKC regulation found in HIV+ asymptomatic patients. Our results indicate that HIV+ sera inhibit significantly normal NKC in a dose-dependent way, even at
Expression of the human mucosal lymphocyte antigen, HML-1, by T cells activated with mitogen or specific antigen in vitro.: Scand J Immunol. 1995 Jun;41(6):553-62. Unique Identifier : AIDSLINE MED/95288585; Brew R; West DC; Burthem J; Christmas SE; Department of Immunology, Royal Liverpool University Hospital,; UK.; Expression of the human mucosal lymphocyte antigen, HML-1 (CD103), recently identified as a novel alpha E beta 7 integrin, was studied on peripheral blood lymphocytes activated with mitogen or specific antigen. HML-1 was up-regulated on PHA activated T-lymphoblasts cultured in 100IU/ml interleukin-2 (
[Cyst-forming Coccidia: Toxoplasma, Neospora, Sarcocystis]: Schweiz Med Wochenschr. 1995 May 6;125(18):890-8. Unique Identifier : AIDSLINE MED/95288612; Gottstein B; Institut fur Parasitologie, Medizinischen Fakultat,; Universitat Bern.; The most important cyst-forming coccidian parasites in human and veterinary medicine belong the genera of Toxoplasma, Neospora and Sarcocystis. Toxoplasma gondii shows its clinical relevance in congenital infections and opportunistic infections in immunodeficient patients. In veterinary medicine the parasite is predom
Cryptosporidia--who is at risk?: Schweiz Med Wochenschr. 1995 May 6;125(18):899-908. Unique Identifier : AIDSLINE MED/95288613; Keusch GT; Hamer D; Joe A; Kelley M; Griffiths J; Ward H; Department of Medicine, New England Medical Center, Tufts; University School of Medicine, Boston, MA, USA.; Cryptosporidium parvum is a coccidian parasite originally described a century ago and, until recently, not considered to be a human pathogen. It has a complex life cycle, including both sexual and asexual reproduction, an auto-infectious cycle, and the ability to complete its development within a single host. The tran
[New parasitic diseases in man: infections caused by Microsporida and Cyclospora species]: Schweiz Med Wochenschr. 1995 May 6;125(18):909-23. Unique Identifier : AIDSLINE MED/95288614; Weber R; Deplazes P; Departement Innere Medizin, Universitatsspital Zurich.; The non-taxonomic term microsporidia relates to a group of organisms belonging to the order Microsporida of the phylum Microspora. Microsporidia are obligate intracellular spore-forming protozoa and have no metabolically active stages outside the host cell. Their host range is extensive and includes most invertebrates
IL-12 at the crossroads [news] [see comments]: Science. 1995 Jun 9;268(5216):1432-4. Unique Identifier : AIDSLINE MED/95288630; Hall SS
[A comparative study of the expression of activation markers on T-lymphocyte subpopulations in different forms of bronchial asthma]: Ter Arkh. 1995;67(3):26-9. Unique Identifier : AIDSLINE MED/95288665; Beda MV; Pavliuk AS; Veselova AV; Dement'eva EG; Solov'ev SS; Bart BIa; Koval'chuk LV; In this study we investigated a phenotype of intact and PHA-stimulated T-lymphocytes from peripheral blood of patients with allergic and nonallergic asthma. Expression of the activation markers (CD25, CD71, HLA-DR) on subsets of T-lymphocytes (CD4+ and CD8+) was determined using double-colour flow cytometry. It was fo
[Confidentiality in HIV-infection/AIDS--a comment on the Communicable Disease Control Act]: Tidsskr Nor Laegeforen. 1995 May 10;115(12):1521-3. Unique Identifier : AIDSLINE MED/95288727; Frich JC; The new Communicable Diseases Control Act has come into force in Norway . It makes it compulsory for a physician to warn a third party if it is obvious that a HIV-positive patient, with a high degree of certainty, puts the third party at risk of being infected with HIV. Some philoso
Prevalence of antibodies to human T-lymphotropic virus types I and II in volunteer blood donors and high-risk groups in northwestern Greece.: Transfusion. 1995 Jun;35(6):503-6. Unique Identifier : AIDSLINE MED/95288770; Dalekos GN; Zervou E; Karabini F; Elisaf M; Bourantas K; Siamopoulos KC; Department of Internal Medicine, University Hospital of Ioannina,; Greece.; BACKGROUND: In addition to human immunodeficiency virus, human T-lymphotropic virus types I and II (HTLV-I/II) is prevalent among blood donors in the United States . In Greece , there are no epidemiolo
Immunohistochemical analysis of T cell phenotypes in patients with graft-versus-host disease following allogeneic bone marrow transplantation.: Transplantation. 1995 May 27;59(10):1436-44. Unique Identifier : AIDSLINE MED/95288801; Diamond DJ; Chang KL; Jenkins KA; Forman SJ; Department of Hematology and Bone Marrow Transplantation, City of; Hope National Medical Center, California, USA.; Allogeneic bone marrow transplantation has become the therapy of choice in many cases of hematologic malignancy. In both matched related donor transplants--and, to a greater degree, in unrelated donor transplant situations--a major complication of the procedure is GVHD. This problem is caused by mature T cells in the
Intestinal spirochetosis and acquired immunodeficiency syndrome: ultrastructural studies of two cases.: Ultrastruct Pathol. 1995 Jan-Feb;19(1):15-22. Unique Identifier : AIDSLINE MED/95288830; Guccion JG; Benator DA; Zeller J; Termanini B; Saini N; Pathology and Laboratory Medicine Service (113), Department of; Veterans Affairs Medical Center, Washington, DC 20422, USA.; Two cases of intestinal spirochetosis (IS) with acquired immunodeficiency syndrome are reported. In case 1, a 48-year-old homosexual black man presented with a 1-month history of alternating watery diarrhea and constipation, which dissipated following the removal of two colonic hyperplastic polyps containing IS. In ca
Autoimmune and inflammatory diseases.: Adv Exp Med Biol. 1994;366:199-213. Unique Identifier : AIDSLINE MED/95289163; Leff JA; Webb-Waring Institute for Biomedical Research, University of; Colorado School of Medicine, Denver 80262, USA.
Cost, risk, regulation, fees [letter] [see comments]: Am J Orthod Dentofacial Orthop. 1995 Jun;107(6):16A-17A. Unique Identifier : AIDSLINE MED/95289270; Oppenhuizen GM
Disseminated cryptococcosis and sudden death. Report of an autopsy case.: Am J Forensic Med Pathol. 1995 Mar;16(1):38-41. Unique Identifier : AIDSLINE MED/95289292; Zappi E; Zappi M; Zugibe FT; Rockland County Medical Examiner's Office, Pomona, New York, USA.; We report a case of sudden death due to terminal cryptococcal pneumonia in a patient not suspected to have AIDS. The correct diagnosis was found only by microscopic examination and serologic workup, illustrating the hazards faced by forensic pathologists and their assistants working without adequate information about
Chronic hepatitis in patients with active hepatitis B virus and hepatitis C virus combined infections: a histological study.: Am J Gastroenterol. 1995 Jun;90(6):955-8. Unique Identifier : AIDSLINE MED/95289342; Villari D; Pernice M; Spinella S; Squadrito G; Rodino G; Brancatelli S; Longo G; Raimondo G; Dipartimento di Patologia Umana, Universita di Messina, Italy.; OBJECTIVES: To evaluate whether peculiar histological changes are present in liver tissue of patients with chronic hepatitis by hepatitis B and hepatitis C (HBV and HCV) virus combined infections. METHODS: We studied liver biopsy specimens from 14 HB surface antigen/anti-HCV-positive patients consecutively admitted to
The efficacy of erythropoietin in human immunodeficiency virus-infected end-stage renal disease patients treated by maintenance hemodialysis.: Am J Kidney Dis. 1995 Jun;25(6):904-9. Unique Identifier : AIDSLINE MED/95289405; Shrivastava D; Rao TK; Sinert R; Khurana E; Lundin AP; Friedman EA; Department of Medicine, Kings County Hospital, Brooklyn, NY, USA.; The superimposition of human immunodeficiency virus (HIV) infection, associated opportunistic infections, and anti-retroviral therapy further worsens the severity of anemia in patients also suffering from end-stage renal disease. A major cause of anemia in renal failure is a deficiency of erythropoietin. The causes of
Alcohol, tumor necrosis factor, and tuberculosis.: Alcohol Clin Exp Res. 1995 Feb;19(1):17-24. Unique Identifier : AIDSLINE MED/95289579; Nelson S; Mason C; Bagby G; Summer W; Department of Pulmonary/Critical Care Medicine, Louisiana State; University Medical Center, New Orleans 70112, USA.; Alcohol exerts potent suppressive effects on the immune system that significantly increase host susceptibility to a variety of infections, particularly pneumonia. Historically, tuberculosis has been strongly associated with alcohol abuse. Although the relationship between alcohol abuse and tuberculosis is widely appre
Tuberculosis in the 1990s.: Alcohol Clin Exp Res. 1995 Feb;19(1):3-5. Unique Identifier : AIDSLINE MED/95289596; Bass JB Jr; Division of Pulmonary and Critical Care Medicine, University of; South Alabama Medical Center, Mobile 36617, USA.; The steady decline in tuberculosis case rate reversed in the mid-1980s, and tuberculosis cases have increased dramatically since that time. Important factors contributing to this increase are the human immunodeficiency virus (HIV) epidemic and tuberculosis occurring in foreign-born persons. Tuberculosis outbreaks have
Pulmonary host defenses.: Alcohol Clin Exp Res. 1995 Feb;19(1):6-10. Unique Identifier : AIDSLINE MED/95289601; Reynolds HY; Department of Medicine, Milton S. Hershey Medical Center,; Pennsylvania State University, Hershey 17033, USA.; Well functioning host defenses in the respiratory tract effectively remove microbes and other debris that reach the conducting airways and alveoli, and this usually prevents infections. People with acute and chronic illnesses can experience failure of any number of these defense mechanisms that allow pneumonia (and ba
Probing the details of the HIV-1 Rev-Rev-responsive element interaction: effects of modified nucleotides on protein affinity and conformational changes during complex formation.: Biochem J. 1995 Jun 1;308 ( Pt 2):447-53. Unique Identifier : AIDSLINE MED/95289974; Renwick SB; Critchley AD; Adams CJ; Kelly SM; Price NC; Stockley PG; Department of Genetics, University of Leeds, U.K.; The solution structure of the human immunodeficiency virus type 1 (HIV-1) Rev-responsive element (RRE) has been investigated by enzymic and chemical structural probing of a 71 nt RRE transcript. The minimum sequence information required to maintain recognition by the Rev protein has previously been mapped to a 29 nt s
[From IgE to the cell adhesion molecule]: Allerg Immunol (Paris). 1995 Apr;27(4):111-5. Unique Identifier : AIDSLINE MED/95290084; Stain JP; C.H.U. de Rouen.; The aim of this work is to contribute to increasing our knowledge of asthma. The IgE can t alone be imputed in the anaphylactic reaction. Asthma is a bronchial inflammatory disease. The secretion of lymphokines increases the inflammatory response. The eosinophils cells damage the respiratory epithelium. The mast cells
Is alcohol consumption a cofactor in the development of acquired immunodeficiency syndrome?: Alcohol. 1995 Mar-Apr;12(2):105-9. Unique Identifier : AIDSLINE MED/95290098; Wang Y; Watson RR; Nutritional Sciences Program, University of Arizona College of; Medicine, Tucson 85724, USA.; Excessive alcohol (EtOH) consumption and acquired immunodeficiency syndrome (AIDS) are two major public health problems in the United States . Overwhelming evidence is showing that heavy EtOH ingestion broadly suppresses the various arms of immune response, seriously impairing the body
Molecular immunobiology of macrophages: recent progress.: Curr Opin Immunol. 1995 Feb;7(1):24-33. Unique Identifier : AIDSLINE MED/95290119; Gordon S; Clarke S; Greaves D; Doyle A; Sir William Dunn School of Pathology, University of Oxford, UK.; Macrophage molecules involved in adhesion, signalling, secretion and interactions with pathogens and T-helper lymphocytes have been cloned and defined using monoclonal antibodies and genetic disruption. Studies of the regulation of macrophage differentiation and activation by cytokines have yielded insights into the h
Help-seeking for AIDS high-risk sexual behavior among gay and bisexual African-American men.: AIDS Educ Prev. 1995 Feb;7(1):1-9. Unique Identifier : AIDSLINE MED/95290330; Peterson JL; Coates TJ; Catania JA; Hilliard B; Middleton L; Hearst N; Georgia State University, Department of Psychology, Atlanta, GA; 30303, USA.; Help-seeking for AIDS high-risk sexual behavior and its association with HIV status were examined among 318 gay and bisexual men in the San Francisco Bay Area who participated in the African American Men s Health Project, a longitudinal survey of gay and bisexual African-American men. A third (36%) of the sample repor
Planning and evaluating strategies for AIDS health education interventions in the Muslim community in Uganda.: AIDS Educ Prev. 1995 Feb;7(1):10-21. Unique Identifier : AIDSLINE MED/95290331; Kagimu M; Marum E; Serwadda D; Islamic Medical Association of Uganda, Kampala.; In 1992 the Islamic Medical Association of Uganda designed an AIDS prevention project. A baseline survey was conducted to assess prevailing knowledge, attitudes, and practices among the Muslim communities in two districts. A low rate of incorrect beliefs about HIV transmission was
HIV risk behavior among homeless adults.: AIDS Educ Prev. 1995 Feb;7(1):22-31. Unique Identifier : AIDSLINE MED/95290332; St Lawrence JS; Brasfield TL; Community Health Program, Jackson State University, MS 39217,; USA.; Very little information is available regarding HIV risk behavior among homeless adults despite increasing evidence that HIV infection disproportionately affects inner-city residents and disadvantaged populations. In the present study, adults (N = 94) entering a storefront medical clinic for the homeless completed an A
Health belief and self-efficacy models: their utility in explaining college student condom use.: AIDS Educ Prev. 1995 Feb;7(1):32-49. Unique Identifier : AIDSLINE MED/95290333; Mahoney CA; Thombs DL; Ford OJ; Department of Health Science, State University of New York at; Brockport 14420, USA.; This investigation tested the ability of the Health Belief Model (HBM), dimensions of self-efficacy, various behavioral variables (i.e., number of sex partners in the past 12 months, frequency of drunkenness during sexual intercourse, and number of diagnosed sexually transmitted diseases), and demographic measures to
Behavioral training and AIDS risk reduction: overcoming barriers to condom use.: AIDS Educ Prev. 1995 Feb;7(1):50-9. Unique Identifier : AIDSLINE MED/95290334; Weisse CS; Turbiasz AA; Whitney DJ; Department of Psychology, Union College, Schenectady, New York; 12308, USA.; To assess the short- and long-term effects of an AIDS-prevention workshop on undergraduates attitudes about condom use and AIDS, 31 participants and 31 controls were studied immediately after training sessions as well as three months later. The workshop was aimed at reducing embarrassment to purchase condoms, encoura
Using students' salient beliefs to design an instructional intervention to promote AIDS compassion and understanding in the middle school.: AIDS Educ Prev. 1995 Feb;7(1):60-73. Unique Identifier : AIDSLINE MED/95290335; Warden MA; Koballa TR Jr; Department of Biology, Ball State University, Muncie, Indiana; 47306, USA.; This article documents the construction and validation of a videotaped message to persuade middle school students to volunteer as the laboratory partner of a classmate who has AIDS. Based on well-established social-psychological models of persuasion, message arguments are designed either to reinforce or to downplay th
Determinants of safe and risk-taking sexual behavior among gay men: a review.: AIDS Educ Prev. 1995 Feb;7(1):74-96. Unique Identifier : AIDSLINE MED/95290336; Hospers HJ; Kok G; Department of Health Education, University of Limburg at; Maastricht, The Netherlands.; Since the outbreak of the AIDS epidemic, gay men have made impressive changes in their sexual behavior. Notwithstanding these changes, there are several studies that show considerable within-subject variability in risk categories, indicating that for a substantial number of gay men it is difficult to be consistently s
Use of subcutaneous implantable infusion systems in neoplastic and AIDS patients requiring long-term venous access.: Eur J Surg. 1995 Feb;161(2):137-42. Unique Identifier : AIDSLINE MED/95290535; Dionigi P; Cebrelli T; Jemos V; Minoli L; Gobbi P; Dimitrov G; Department of Surgery, University of Pavia, Italy.; OBJECTIVE: To evaluate the life span and complication rates of totally implantable infusion devices in patients with short bowel syndrome and in immunocompromised patients with AIDS, lymphoma, and myeloma who required long-term central venous access. DESIGN: Prospective open study. SETTING: University hospital,
[S. pneumoniae sternoclavicular arthritis in a patient with HIV infection]: An Med Interna. 1994 Aug;11(8):395-7. Unique Identifier : AIDSLINE MED/95290593; Leon M; Ramos M; Saavedra J; Dominguez A; Ferrer T; Pujol E; Servicio de Medicina Interna, Hospital General de Huelva.; HIV infection is a predisposing factor for pneumococcic infection. While pneumonia is the most frequent location, other locations (articular, meningeal, endocardiac, etc) have been less frequently described. Among the articular infections described in patients with HIV infection, the sternoclavicular affection is extr
[Visceral leishmaniasis and AIDS. Report of 2 cases with cutaneous dissemination]: An Med Interna. 1994 Aug;11(8):398-400. Unique Identifier : AIDSLINE MED/95290594; Belda Mira A; Diaz Sanchez F; Martinez Garcia B; Gonzalvo Bellver E; Anton Crespo V; Redon Mas J; Servicio de Medicina Interna, Dermatologia y Anatomia; Patologica, Hospital de Sagunto, Valencia.; The cutaneous affection in visceral leishmaniasis (VL) or Kala-azar, is well known although poorly documented. The coinfection by the human immunodeficiency virus (HIV) has resulted in the development of frequent atypical forms of VL, increasing the descriptions of cutaneous affection in its evolution. We present two
[Acute abdomen secondary to intestinal tuberculosis in a patient with HIV infection (letter)]: An Med Interna. 1994 Aug;11(8):412-3. Unique Identifier : AIDSLINE MED/95290598; Sanchez Perez MA; Mateos Rodriguez F; Henarejos Lopez A; Fuertes Martin A
Peptide T from human immunodeficiency virus does not interact with VIP receptor-effector system in immunocompetent cells of rat and mouse.: Biosci Rep. 1994 Oct;14(5):251-7. Unique Identifier : AIDSLINE MED/95290624; Pozo D; Segura JJ; Guerrero JM; Calvo JR; Department of Medical Biochemistry and Molecular Biology,; University of Seville School of Medicine, Spain.; Human immunodeficiency virus (HIV) infection is initiated by attachment of the virus to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is an appreciable structural similarity between peptide T and an eight amino acid sequence of V
Community treatment of HIV-1: initial stage and asymptotic dynamics.: Biosystems. 1995;35(1):75-81. Unique Identifier : AIDSLINE MED/95290630; Hsieh YH; Velasco-Hernandez JX; Department of Applied Mathematics National Chung-Hsing; University, Taichung, Taiwan ROC.; Treatment with antiviral drugs (zidovudine and ddI) has been reported to delay progression to AIDS, and may even possibly lower the infectiousness of the infectives. However, its effect on the community level is still uncertain. The latter is important since a successful community treatment program must meet both publ
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in adult T-cell leukemia (ATL) in non-ATL-endemic Hokkaido of Japan.: In Vivo. 1994 Nov-Dec;8(6):1007-10. Unique Identifier : AIDSLINE MED/95290633; Iwanaga M; Takada K; Fujiwara S; Oikawa O; Sugiura M; Imai S; Osato T; Mikuni C; Maekawa I; Miyazaki T; et al; Department of Virology, Hokkaido University School of Medicine,; Sapporo, Japan.; Sera and peripheral blood lymphocytes of 40 adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido were examined for the prevalence of human T-cell leukemia virus type 1 (HTLV-I). All patients had HTLV-I-specific antibodies. When the peripheral lymphocytes were assessed after short-term cultivation, HTLV-I a
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in general inhabitants in non-adult T-cell leukemia (ATL)-endemic Hokkaido, Japan.: In Vivo. 1994 Nov-Dec;8(6):1011-4. Unique Identifier : AIDSLINE MED/95290634; Kwon KW; Yano M; Sekiguchi S; Iwanaga M; Fujiwara S; Oikawa O; Sugiura M; Imai S; Osato T; Department of Research, Hokkaido Red Cross Blood Center, Sapporo,; Japan.; In contrast to adult T-cell leukemia (ATL)-endemic southwestern Japan , the northernmost island Hokkaido has a small number of ATL patients annually. In this study, we surveyed 32,587 healthy inhabitants throughout Hokkaido for antibodies to human T-cell leukemia virus type 1 (HTLV-I
Cryptic dysfunction of cellular immunity in asymptomatic human immunodeficiency virus (HIV) carriers and its actualization by an environmental immunosuppressive factor.: In Vivo. 1994 Nov-Dec;8(6):1019-22. Unique Identifier : AIDSLINE MED/95290636; Sugiura M; Imai S; Sakurada K; Miyazaki T; Osato T; Department of Virology, Hokkaido University School of Medicine,; Sapporo, Japan.; Peripheral blood lymphocytes from 4 asymptomatic HIV-1 carriers with normally retained EBV-specific cytotoxic T-cell activity were exposed to EBV and incubated with 0.2 ng/ml 4-deoxyphorbol ester, an immunosuppressive substance derived from an African plant Euphorbia tirucalli. The regression of EBV-induced B-cell tra
Clonal outgrowths of T and B cells in SCID mice reconstituted with cells from mice with MAIDS.: In Vivo. 1994 Nov-Dec;8(6):953-9. Unique Identifier : AIDSLINE MED/95290654; Tang Y; Chattopadhyay SK; Hartley JW; Fredrickson TN; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.; Murine acquired immunodeficiency syndrome (MAIDS), induce in mice by a defective murine retrovirus (BM5def), is characterized by development of severe immunodeficiency and polyclonal lymphoid proliferation which progress to yield oligoclonal populations of T and B cells. Oligoclonal populations transferred to SCID mic
[Testing the knowledge of pupils and students about cancer and HIV/AIDS before and after the transmission of an educational message]: Bacteriol Virusol Parazitol Epidemiol. 1994 Jul-Dec;39(3-4):125-40. Unique Identifier : AIDSLINE MED/95290829; Ciufecu C; Vrinceanu L; Tripsa M; Surtea A; Rebosapca R; Calugaru A; Denisov M; Ibrahim S; Sesovici O; Tudorica M; et al; Institutul Cantacuzino.
Registration of drugs for treating cancer and HIV infection: a plea to carry out phase 3 trials before admission to the market.: BMJ. 1995 May 20;310(6990):1305-6. Unique Identifier : AIDSLINE MED/95291039; Koopmans PP; Department of Medicine, University Hospital Nijmegen,; Netherlands.; Drugs for cancer and HIV infection tend to be admitted to the market on the basis of results from phase 2 trials. Assessing the benefit-risk balance with phase 2 trials often is difficult--the effect of the drug is usually temporary; the correlation between response or improvement of clinical measurements and the pati
HIV risk-taking behaviour among injecting drug users currently, previously and never enrolled in methadone treatment.: Addiction. 1995 Apr;90(4):545-54. Unique Identifier : AIDSLINE MED/95291114; Baker A; Kochan N; Dixon J; Wodak A; Heather N; National Drug & Alcohol Research Centre, University of New South; Wales, Sydney, Australia.; This study compares the injecting and sexual risk-taking behaviour among injecting drug users (IDUs) currently, previously and never enrolled in methadone maintenance treatment (MMT). All subjects had injected during the 6 months prior to the day of interview. The current MMT group showed significantly lower injecting
Bispecific antibody-mediated cytotoxicity by CD4+ and CD8(+)-activated T cells generated from leukemia patients after allogeneic bone marrow transplantation.: Bone Marrow Transplant. 1995 Feb;15(2):193-8. Unique Identifier : AIDSLINE MED/95291217; Hattori K; Tsukamoto H; Ohta S; Yabe M; Yabe H; Kato S; Takakura I; Ueda R; Habu S; Nishimura T; Department of Pediatrics, Tokai University School of Medicine,; Isehara, Japan.; The F(ab )2 bispecific antibody (BSAb) was prepared from anti-CD3 moAb and anti-CD10 moAb. The BSAb could react with both CD3+ T cells and CD10+ leukemia cells and triggered T cell-mediated cytotoxicity. To apply the BSAb to prevention of leukemic relapse after BMT, we investigated the generation of both CD4+ and CD8+
Selective T cell depletion with CD8-conjugated magnetic beads in the prevention of graft-versus-host disease after allogeneic bone marrow transplantation.: Bone Marrow Transplant. 1995 Feb;15(2):271-8. Unique Identifier : AIDSLINE MED/95291229; Jansen J; Hanks S; Akard L; Martin M; Thompson J; Chang Q; Ash R; Garrett P; Figg F; English D; Bone Marrow Transplantation Program, Methodist Hospital of; Indiana, Indianapolis 46206-1367, USA.; The effects of a new immunomagnetic method of selectively depleting CD8+ lymphocytes from donor bone marrow were studied in 29 patients undergoing transplantation from HLA-identical sibling (n = 20) or alternative (n = 9) donors. The direct immunomagnetic depletion method consistently removed > 95% of CD8+ cells and t
HLA-DR expression on CD8 lymphocytes from gastric mucosa in urease-positive and urease-negative gastritis.: FEMS Immunol Med Microbiol. 1995 Feb;10(3-4):295-9. Unique Identifier : AIDSLINE MED/95291272; Ihan A; Krizman I; Ferlan-Marolt V; Tepez B; Gubina M; Institute of Microbiology, Medical Faculty, Ljubljana, Slovenia.; We isolated lymphocytes from chronically inflamed gastric mucosa. We analysed the expression of IL-2 receptors (CD25), transferin receptors (CD71) and HLA-DR molecules on T lymphocytes by flow cytometric analysis in 16 patients with urease-positive and in 7 patients wi
A case of AIDS-related hepatic Kaposi's sarcoma.: J Gastroenterol. 1995 Apr;30(2):268-72. Unique Identifier : AIDSLINE MED/95291404; Tanaka T; Masuda G; Takechi A; Kobayashi H; Tanaka S; Koike M; Hattori N; Liver Unit, Tokyo Metropolitan Komagome Hospital, Japan.; In Japan , Kaposi s sarcoma (KS) is a very rare neoplasm. However, it does occur as one of the complications in patients with acquired immunodeficiency syndrome (AIDS). AIDS-related KS commonly involves the skin, lymph nodes, and gastrointestinal tract. Hepatic KS is sometimes observ
Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis.: Microbiology. 1995 May;141 ( Pt 5):1173-81. Unique Identifier : AIDSLINE MED/95291460; Foley-Thomas EM; Whipple DL; Bermudez LE; Barletta RG; Department of Veterinary and Biomedical Sciences, University of; Nebraska, Lincoln 68583-0905, USA.; Mycobacterium avium complex strains and Mycobacterium paratuberculosis are closely related intracellular pathogens affecting humans and animals. M. avium complex infections are a leading cause of morbidity and mortality in AIDS patients, and M. paratuberculosis is the agent of Johne s disease in ruminants. Genetic man
Tuberculosis in the homeless.: Arch Fam Med. 1995 Jun;4(6):541-6. Unique Identifier : AIDSLINE MED/95291481; Barclay DM 3rd; Richardson JP; Fredman L; Department of Family Medicine, University of Maryland School of; Medicine, Baltimore, USA.; The prevalence of tuberculosis in the homeless is on the rise. The presence of human immunodeficiency virus and multidrug-resistant tuberculosis in the homeless has contributed to this high prevalence. Several factors, including alcoholism, substance abuse, and psychiatric illness, combine to make it difficult to diag
HIV retrotransposon activity and the immunopathogenesis of AIDS.: Trends Microbiol. 1995 Mar;3(3):115-7. Unique Identifier : AIDSLINE MED/95291653; Johnson EJ; Sizemore RC; Gottlieb AA; Dept of Microbiology and Immunology, Tulane University School of; Medicine, New Orleans, LA 70112-2699, USA.; This article presents the new hypothesis that HIV retrotransposon insertional mutagenesis induces genomic effects that bring about immune dysfunction through disruption, deletion or rearrangement of the genome of the host. This activity may be augmented by the action of most, if not all, the cofactors of HIV-induced d
Aluminum oxide crystal microdermabrasion. A new technique for treating facial scarring.: Dermatol Surg. 1995 Jun;21(6):539-42. Unique Identifier : AIDSLINE MED/95291666; Tsai RY; Wang CN; Chan HL; Department of Dermatology, Chang Gung Memorial Hospital, Taipei,; Taiwan.; BACKGROUND. Aluminum oxide crystal microdermabrasion, a newly developed technique, has the advantages of less bleeding, fewer complications, better compliance, and no need for local anesthesia or high surgical skill in comparison with traditional dermabrasion. OBJECTIVE. To demonstrate the effectiveness of this new te
Bovine collagen products and gelatin sponges for hemostasis in punch biopsies of HIV-1+ patients [letter]: Dermatol Surg. 1995 Jun;21(6):563-4. Unique Identifier : AIDSLINE MED/95291671; Smith KJ; Skelton HG; Yeager J; Wagner KF
Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.: Bioorg Med Chem. 1994 Oct;2(10):1051-6. Unique Identifier : AIDSLINE MED/95291686; Lee TT; Kashiwada Y; Huang L; Snider J; Cosentino M; Lee KH; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599, USA.; Suksdorfin (1), which is isolated from the fruit of Lomatium suksdorfii, was found to be able to inhibit HIV-1 replication in the T cell line, H9, with an average EC50 value of 2.6 +/- 2.1 microM. In addition, suksdorfin was also suppressive during acute HIV-1 infections of peripheral blood mononuclear cells, monocyte
The synthesis of novel HIV-protease inhibitors.: Bioorg Med Chem. 1994 Oct;2(10):1075-83. Unique Identifier : AIDSLINE MED/95291689; Girijavallabhan VM; Bennett F; Patel NM; Ganguly AK; Dasmahapatra B; Butkiewicz N; Hart A; Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.; The syntheses, enzyme inhibition and antiviral activity of potent HIV- protease inhibitors containing novel beta-hydroxy ether and thioethers based on the transition state mimetic concept are discussed.
Alpha-ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease.: Bioorg Med Chem. 1994 Oct;2(10):1085-90. Unique Identifier : AIDSLINE MED/95291690; Munoz B; Giam CZ; Wong CH; Department of Chemistry, Scripps Research Institute, La Jolla, CA; 92037, USA.; Studies on the inhibition of HIV-1 protease utilizing a core isostere with replacement of the scissle bond for an alpha-amino-ketone have resulted in the development of an alpha-keto-amide isosteric replacement of the Phe-Pro scissle amide bond. The simple dipeptide isostere was shown to be a promising new core struct
Avascular necrosis of the medial femoral condyle in HIV-infected patients.: Am J Orthop. 1995 Jan;24(1):71-3. Unique Identifier : AIDSLINE MED/95291940; Stovall D Jr; Young TR; Section of Orthopaedic Surgery, Medical College of Georgia,; Augusta, USA.; Avascular necrosis (AVN) of the femoral head has been described in the literature in patients infected with the human immunodeficiency virus. It has been associated with either a hypertriglyceridemic state or the presence of antiphospholipid antibodies. We describe a case of AVN of the medial femoral condyle in an HIV
HIV in the accident and emergency department.: Accid Emerg Nurs. 1995 Apr;3(2):83-8. Unique Identifier : AIDSLINE MED/95292005; Sinclair D; This article is intended as an introduction to some of the issues which arise from the increasing incidence in the UK of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS). It is not possible fully to address, nor offer answers to, all of these issues. HIV and AIDS present many challenge
Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase.: Nat Struct Biol. 1995 Mar;2(3):244-9. Unique Identifier : AIDSLINE MED/95292110; Baldwin ET; Bhat TN; Liu B; Pattabiraman N; Erickson JW; Frederick Biomedical Supercomputing Center, PRI/DynCorp, National; Cancer Institute-Frederick Cancer Research and Development; Center, Maryland 21702-1201, USA.; A major problem in the development of antiviral therapies for AIDS has been the emergence of drug resistance. We report an analysis of the structure of a Val 82 to Ala mutant of HIV-1 proteinase complexed to A-77003, a C2 symmetry-based inhibitor. Modelling studies predicted that the V82A mutation would result in decr
AIDS in Manila, Philippines.: N Hc Perspect Community. 1995 May;16(3):116. Unique Identifier : AIDSLINE MED/95292125; Salamat
New AIDS-treatment manual in BC [news]: Can Med Assoc J. 1995 Jun 1;152(11):1843. Unique Identifier : AIDSLINE MED/95292220
HIV-specific lymphoproliferative responses in asymptomatic HIV-infected individuals.: Clin Exp Immunol. 1995 Jun;100(3):419-24. Unique Identifier : AIDSLINE MED/95292388; Pontesilli O; Carlesimo M; Varani AR; Ferrara R; Guerra EC; Bernardi ML; Ricci G; Mazzone AM; D'Offizi G; Aiuti F; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; In vitro lymphoproliferative responses to HIV-1 recombinant antigens (gp160, p24, and Rev protein) were studied in 83 patients with asymptomatic HIV-1 infection (CDC groups II and III) and circulating CD4 lymphocyte numbers > 400/mm3. Significant response to at least one of the three antigens was detected in 52.4% of
[The nervous system involvement in human retroviral infection]: Rinsho Shinkeigaku. 1994 Dec;34(12):1262-4. Unique Identifier : AIDSLINE MED/95292471; Kira J; Department of Neurology, Faculty of Medicine, Kyushu University.; Human T-lymphotropic virus type I (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM). A chronic inflammatory process has been implicated in HAM by a pathological study, but the exact mechanism still remains to be elucidated. Our quantitative
Contact allergy to gold sodium thiosulfate.: Contact Dermatitis. 1995 Mar;32(3):143-6. Unique Identifier : AIDSLINE MED/95292526; McKenna KE; Dolan O; Walsh MY; Burrows D; Department of Dermatology, Royal Victoria Hospitals Trust,; Belfast, Northern Ireland, UK.; 278 consecutive patients with suspected contact dermatitis were patch tested with the European standard series and gold sodium thiosulfate (0.5% pet.): 13 patients (4.6%) had a positive allergic response to gold sodium thiosulfate (GST). All of these patients were female, with a mean age of 37 years. The most frequent
Long-term survival after intensive care unit admission with sepsis.: Crit Care Med. 1995 Jun;23(6):1040-7. Unique Identifier : AIDSLINE MED/95292556; Sasse KC; Nauenberg E; Long A; Anton B; Tucker HJ; Hu TW; School of Medicine, University of California at San Francisco,; USA.; OBJECTIVE: To evaluate the long-term survival of critically ill patients with sepsis and to assess the factors predictive of long-term survival (> 1 month after admission date). DESIGN: Prospective, cohort study. SETTING: Medical/surgical intensive care unit (ICU) in a multidisciplinary community hospital. PATIENTS: A
The role of two-segment bronchoalveolar lavage in the diagnosis of pulmonary infections.: Chest. 1994 Aug;106(2):414-20. Unique Identifier : AIDSLINE MED/95292657; Grebski E; Russi EW; Speich R; Opravil M; Kuster H; Wust J; Department of Internal Medicine, University Hospital of Zurich,; Switzerland.; STUDY OBJECTIVE: To determine if performing bronchoalveolar lavage (BAL) from more than one lung segment augments the diagnostic yield in patients with pulmonary infection. PATIENTS AND STUDY DESIGN: Seventy-six patients who underwent bisegmental BAL for the diagnosis or exclusion of pulmonary infection were studied p
Bronchodilator pretreatment improves aerosol deposition uniformity in HIV-positive patients who cough while inhaling aerosolized pentamidine.: Chest. 1994 Aug;106(2):421-6. Unique Identifier : AIDSLINE MED/95292658; Harrison KS; Laube BL; Division of Infectious Diseases, Johns Hopkins Medical; Institutions, Baltimore, USA.; OBJECTIVE: To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. DESIGN: Nonrandomized control trial. SETTING: A university hospital. PATIENTS: Ten HIV-positive patients who were using AP prophylactically.
Respiratory care practitioners' attitudes toward patients with AIDS.: Chest. 1994 Aug;106(2):427-30. Unique Identifier : AIDSLINE MED/95292659; Dubois JM; Beebie M; Bartter TC; Pratter MR; Division of Pulmonary and Critical Care Medicine, Cooper; Hospital/University Medical Center, Camden, NJ, USA.; OBJECTIVE: To assess attitudes of respiratory care practitioners about AIDS and patients with AIDS. DESIGN: A questionnaire that explored attitudes about AIDS was disseminated throughout southern New Jersey. Identity of individual responders was protected carefully. RESULTS: One hundred fifty-nine responses were recei
Preventive therapy for contacts of multidrug-resistant tuberculosis. A Delphi survey.: Chest. 1994 Aug;106(2):431-4. Unique Identifier : AIDSLINE MED/95292660; Passannante MR; Gallagher CT; Reichman LB; Department of Preventive Medicine and Community Health,; University of Medicine and Dentistry, New Jersey Medical School,; Newark, USA.; OBJECTIVE: Several outbreaks of multidrug resistant tuberculosis (MDR-TB) have recently occurred in which healthcare workers and others have become infected. Given the lack of clinical data to guide preventive therapy for such contacts, a Delphi survey of a panel of 31 TB therapy experts was undertaken to identify a c
Bronchogenic carcinoma in patients seropositive for human immunodeficiency virus.: Chest. 1994 Aug;106(2):640-2. Unique Identifier : AIDSLINE MED/95292708; Aaron SD; Warner E; Edelson JD; Department of Medicine, St. Michael's Hospital, University of; Toronto, Ontario, Canada.; The purpose of this report is to describe an association between bronchogenic carcinoma and HIV. Three HIV-seropositive patients are described who developed bronchogenic cancer (two large cell, one adenocarcinoma) before developing an AIDS-defining illness. A critical review of the literature revealed 22 other patient
Mechanical ventilation for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome [letter; comment]: Chest. 1994 Aug;106(2):643-4. Unique Identifier : AIDSLINE MED/95292710; Franklin CM; Friedman Y
Diagnosis of Pneumocystis carinii infection in HIV-seropositive patients by identification of P carinii in pleural fluid [letter; comment]: Chest. 1994 Aug;106(2):644. Unique Identifier : AIDSLINE MED/95292711; Ewig S; Rockstroh J
Prospects for the use of antioxidant therapies.: Drugs. 1995 Mar;49(3):345-61. Unique Identifier : AIDSLINE MED/95292865; Maxwell SR; Department of Medicine, Queen Elizabeth Hospital, Birmingham,; England.; Free radical oxidative stress has been implicated in the pathogenesis of a variety of human diseases. Natural antioxidant defences have been found to be defective in many of the same diseases. This has led to suggestions that oxidative damage and therefore disease progression may be retarded by supplementing natural a
Virus-induced increases in airway mast cells in brown Norway rats are associated with enhanced pulmonary viral replication and persisting lymphocytic infiltration.: Exp Lung Res. 1995 Mar-Apr;21(2):197-213. Unique Identifier : AIDSLINE MED/95292898; Sorden SD; Castleman WL; Department of Comparative and Experimental Pathology, College of; Veterinary Medicine, University of Florida, Gainesville, USA.; Brown Norway (BN) rats are more susceptible than Fischer 344 (F344) rats to parainfluenza virus-induced lung injury and to bronchiolar mast cell increases that are associated with persistent airway hyperresponsiveness. In this study, pulmonary viral replication as well as immune, i
T cells made deficient in interleukin-2 production by exposure to staphylococcal enterotoxin B in vivo are primed for interferon-gamma and interleukin-10 secretion.: Eur J Immunol. 1995 May;25(5):1148-53. Unique Identifier : AIDSLINE MED/95293004; Florquin S; Amraoui Z; Goldman M; Laboratoire Pluridisciplinaire de Recherche Experimentale; Biomedicale, Hopital Erasme, Universite Libre de Bruxelles,; Belgium.; The superantigen staphylococcal enterotoxin B (SEB) induces a defect in interleukin (IL)-2 production by T cells expressing specific T cell receptor V beta domains. The present study was undertaken to determine the capacity of T cells, made deficient in IL-2 production
Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo.: Eur J Immunol. 1995 May;25(5):1168-75. Unique Identifier : AIDSLINE MED/95293007; Kelso A; Groves P; Troutt AB; Francis K; Walter and Eliza Hall Institute of Medical Research, Parkville,; Australia.; The diversity of cytokine production patterns displayed by T cells activated in vivo was investigated by analyzing short-term antigen-specific CD4+ T cell clones and single CD4+ T cells derived from draining lymph nodes of mice undergoing a T helper 2 (Th2)-like response to keyhole limpet hemocyanin (KLH). On average,
Depletion of CD8+ T cells suppresses the development of experimental autoimmune myasthenia gravis in Lewis rats.: Eur J Immunol. 1995 May;25(5):1191-8. Unique Identifier : AIDSLINE MED/95293010; Zhang GX; Ma CG; Xiao BG; Bakhiet M; Link H; Olsson T; Division of Neurology, Karolinska Institute, Huddinge, University; Hospital, Sweden.; To understand the role of CD8+ T cells in experimental autoimmune myasthenia gravis (EAMG), CD8+ T cells were depleted by injecting a monoclonal anti-rat CD8 antibody (OX8) into Lewis rats immunized with Torpedo acetylcholine receptor (AChR) in complete Freund s adjuvant (CFA). CD8-depleted EAMG rats showed strikingly
Generation of antigen-specific CD4+ T cell lines from naive precursors.: Eur J Immunol. 1995 May;25(5):1206-11. Unique Identifier : AIDSLINE MED/95293012; Mehta-Damani A; Markowicz S; Engleman EG; Department of Pathology, Stanford University School of Medicine,; Palo Alto, CA, USA.; The conditions required for sensitizing naive T cells to nominal antigen are poorly understood. In this report we describe an in vitro system for generating antigen-specific CD4+ T cells from previously unprimed individuals. Freshly isolated CD4+ T cells were cultured with keyhole limpet hemocyanin (KLH), sperm whale
HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling.: Eur J Immunol. 1995 May;25(5):1417-25. Unique Identifier : AIDSLINE MED/95293043; Hubert P; Bismuth G; Korner M; Debre P; Laboratoire d'Immunologie Cellulaire et Tissulaire, CNRS URA 625,; Paris, France.; Using the CD4+ human T cell clone P28, we demonstrated that the HIV-1 glycoprotein gp120 inhibited CD3-induced inositol trisphosphate production, calcium influx and T cell proliferation. Additionally, gp120 was shown to dissociate the tyrosine kinase p56lck from CD4 in CEM cells, with a concommittant inhibition of CD4
A 17-kDa CD4-binding glycoprotein present in human seminal plasma and in breast tumor cells.: Eur J Immunol. 1995 May;25(5):1461-4. Unique Identifier : AIDSLINE MED/95293051; Autiero M; Cammarota G; Friedlein A; Zulauf M; Chiappetta G; Dragone V; Guardiola J; International Institute of Genetics and Biophysics, CNR, Naples,; Italy.; We previously isolated gp17, a human seminal plasma glycoprotein, which specifically interacts with the D1-D2 region of CD4, a T cell surface molecule involved in antigen recognition mediated by helper T cells also acting as a receptor for the human immunodeficiency virus. In this study we report that monoclonal antib
Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1.: FEBS Lett. 1995 May 22;365(1):95-7. Unique Identifier : AIDSLINE MED/95293134; Gu M; Rappaport J; Leppla SH; Laboratory of Microbial Ecology, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892, USA.; The envelope glycoproteins of HIV are required for viral infectivity. Proteolysis of the precursor envelope glycoprotein gp160 results in the formation of gp120 and gp41. Cleavage occurs after the sequence Arg-Glu-Lys-Arg. This sequence is expected to be a substrate for the cellular protease furin. We examined whether
Obstetric and perinatal outcome in human immunodeficiency virus-infected pregnant women with and without opiate addiction.: Eur J Obstet Gynecol Reprod Biol. 1995 Feb;58(2):135-40. Unique Identifier : AIDSLINE MED/95293153; Mauri A; Piccione E; Deiana P; Volpe A; Department of Obstetrics and Gynecology, University of Cagliari,; Italy.; This study was undertaken to assess the impact on gestation played by the simple human immunodeficiency virus (HIV)-seropositive status either alone or complicated by opiate abuse in the absence of other confounding variables. To this purpose the main obstetric complications and the perinatal outcome were prospectivel
Evaluation of anti-HTLV-1 antibody in primary glomerulonephritis.: J Int Med Res. 1995 Jan-Feb;23(1):56-60. Unique Identifier : AIDSLINE MED/95293174; Namie S; Shimamine R; Ichinose H; Nishikawa Y; Ideguchi M; Ozono Y; Harada T; Hara K; Second Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; Human T-cell leukaemia virus type-1 (HTLV-1) is known to cause adult T-cell leukaemia. The prevalence of anti-HTLV-1 antibody in haemodialysis patients has been reported to be higher than that in the general population. The anti-HTLV-1 antibody-positive rate in patients with primary glomerulonephritis in the Nagasaki
[Epstein-Barr virus-specific immunity in asymptomatic carriers of human T-cell leukemia virus type 1]: Hokkaido Igaku Zasshi. 1995 Mar;70(2):315-28. Unique Identifier : AIDSLINE MED/95293318; Kwon KW; Department of Research, Hokkaido Red Cross Blood Center, Sapporo,; Japan.; Adult T-cell leukemia (ATL) patients are immunosuppressed as evidenced by anergy to recall antigens and the occurrence of opportunistic infections. The immunosuppression appears to be a critical factor or a predictive sign for the development of ATL in carriers of human T-cell leukemia virus type 1 (HTLV-1). This stud
CD30-positive anaplastic large cell lymphoma in a human T-cell lymphotropic virus-I endemic area.: Hum Pathol. 1995 Jun;26(6):614-9. Unique Identifier : AIDSLINE MED/95293343; Takeshita M; Ohshima K; Akamatsu M; Ohgami A; Kikuchi M; Suzumiya J; Uike N; Okamura T; Nakayama J; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese
Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).: Genomics. 1995 Jan 1;25(1):66-72. Unique Identifier : AIDSLINE MED/95293411; Kozak CA; Gatignol A; Graham K; Jeang KT; McBride OW; Laboratory of Molecular Microbiology, National Institutes of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA.; Productive infection with HIV-1, the virus responsible for AIDS, requires the involvement of host cell factors for completion of the replicative cycle, but the identification of these factors and elucidation of their specific functions has been difficult. A human cDNA, TRBP, was recently cloned and characterized as a
Stereoselective synthesis of Xaa psi[CH2CH(OH)]Yaa dipeptidomimetics and their inclusion in HIV-1 protease inhibitors.: Int J Pept Protein Res. 1995 Jan;45(1):1-10. Unique Identifier : AIDSLINE MED/95293471; Chen HG; Tustin JM; Wuts PG; Sawyer TK; Smith CW; Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan, USA.; Two stereoselective syntheses of a new pseudodipeptide isostere, the right-hand hydroxyethylene dipeptidomimetic (Xaa psi[CH2CH(OH)]Yaa), are presented. In one method readily available amino acids are used as starting materials for Evans chiral aldol condensation chemistry. The second method relies on the synthesis of
Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy.: Int J Pept Protein Res. 1995 Jan;45(1):35-43. Unique Identifier : AIDSLINE MED/95293475; Wray V; Federau T; Henklein P; Klabunde S; Kunert O; Schomburg D; Schubert U; Department of Molecular Structure Research, Institute of; Biotechnological Research, Braunschweig, Germany.; The HIV-1 specific Vpu is a class I oligomeric membrane phosphoprotein of unknown structure and mechanism. The first experimental evidence for the position of secondary structural elements present in the hydrophilic C-terminal region of Vpu under various solution regimes is reported. CD data for nine overlapping 15 am
Psychic reality and clinical technique.: Int J Psychoanal. 1995 Feb;76 ( Pt 1):3-7. Unique Identifier : AIDSLINE MED/95293503; Berenstein I
[Immune dysregulation and malignant lymphoma]: Internist (Berl). 1995 Apr;36(4):367-71. Unique Identifier : AIDSLINE MED/95293556; Tesch H; Doerfler W; Engert A; Hansmann M; Radbruch A; Rajewsky K; Wolf J; Diehl V; Klinik I fur Innere Medizin, Universitat Koln.
Pretreatment with beta-funaltrexamine blocks morphine-mediated suppression of CTL activity in alloimmunized mice.: Immunopharmacology. 1995 Mar;29(2):129-40. Unique Identifier : AIDSLINE MED/95293637; Carpenter GW; Carr DJ; Department of Microbiology, Immunology and Parasitology, LSU; Medical Center, New Orleans 70112-1393, USA.; The effect of prolonged exposure to morphine on cytotoxic T lymphocytes (CTL) and splenic natural killer (NK) activity was investigated. Daily administration of morphine (50.0 mg/kg, s.c.) to alloimmunized mice for 11 days resulted in a significant decrease (25-50%) in peritoneal and splenic CTL activity but not splen
Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production.: Immunopharmacology. 1995 Mar;29(2):93-101. Unique Identifier : AIDSLINE MED/95293643; Snijdewint FG; Kapsenberg ML; Wauben-Penris PJ; Bos JD; Department of Dermatology, University of Amsterdam, The; Netherlands.; Corticosteroids (CS) are very potent immunosuppressive agents and are widely used to treat inflammatory diseases. On the basis of their clinical efficacy and potency CS have been divided into different classes. In the present study we investigated whether the class-associated effects of CS are correlated with a differ
Headache and the human immunodeficiency virus type 1 infection.: Headache. 1995 May;35(5):245-55. Unique Identifier : AIDSLINE MED/95293668; Holloway RG; Kieburtz KD; University of Rochester (NY) School of Medicine and Dentistry,; USA.; This review focuses on the prevalence, causes, evaluation, and treatment of headache in individuals infected with human immunodeficiency virus type 1 (HIV-1). Headaches, one of the commonest medical complaints in the general population, occur frequently in patients infected with the HIV-1. HIV-related headaches can oc
GE20372 factor A and B. New HIV-1 protease inhibitors, produced by Streptomyces sp. ATCC 55925.: J Antibiot (Tokyo). 1995 Apr;48(4):332-4. Unique Identifier : AIDSLINE MED/95293783; Stefanelli S; Cavaletti L; Sarubbi E; Ragg E; Colombo L; Selva E; Marion Merrell Dow Research Institute, Lepetit Research Center,; Gerenzano (VA) Italy.
Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes.: J Biol Chem. 1995 Jun 9;270(23):13660-4. Unique Identifier : AIDSLINE MED/95293956; Mao F; Rechtin TM; Jones R; Cantu AA; Anderson LS; Radominska A; Moyer MP; Drake RR; Department of Biochemistry and Molecular Biology, University of; Arkansas for Medical Sciences, Little Rock 72205, USA.; Long term administration of 3 -azidothymidine ( AZT ) for the treatment of AIDS has led to detrimental clinical side effects in some patients, the biochemical causes of which are still being delineated. Base-substituted, azido-nucleotide photoaffinity a
Human T-lymphotropic virus type I-associated uveitis in patients with Graves' disease treated with methylmercaptoimidazole.: J Clin Endocrinol Metab. 1995 Jun;80(6):1904-7. Unique Identifier : AIDSLINE MED/95294222; Mizokami T; Okamura K; Kohno T; Sato K; Ikenoue H; Kuroda T; Inokuchi K; Fujishima M; Second Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka, Japan.; Human T-lymphotropic virus type I (HTLV-I) is responsible for a certain form of uveitis [HTLV-I-associated uveitis (HAU)]. A previous history of Graves disease has been reported in 9-17% of the patients with HAU. In this study, the prevalence of patients with either HTLV-I antibody or uveitis was evaluated in 819 con
DNA inoculation as a novel vaccination method against human retroviruses with rheumatic disease associations.: Immunol Res. 1994;13(2-3):154-62. Unique Identifier : AIDSLINE MED/95294402; Ugen KE; Wang B; Ayyavoo V; Agadjanyan M; Boyer J; Li F; Kudchodkar S; Lin J; Merva M; Fernandes L; et al; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia 19104, USA.; There are a number of rheumatologic manifestations of human retroviral infections associated with human immunodeficiency virus type I (HIV-I) and the human T-cell leukemia virus type I (HTLV-I) including arthritis, Sjogren s syndrome-like symptoms as well as other varied autoimmune phenomena. Infection with HTLV-1 may
Study of the knowledge, attitude of Egyptian health care workers towards occupational HIV infection.: J Egypt Public Health Assoc. 1994;69(1-2):115-28. Unique Identifier : AIDSLINE MED/95294490; Faris R; Shouman A; Faculty of Medicine, Ain Shams University.; Acquired immuno-deficiency syndrome (AIDS) was reported for the first time in Egypt in 1986. Up to March 1993, 60 cases were notified to the Ministry of Health and 359 were detected to be infected with human immunodeficiency virus (HIV). Most cases had acquired infection abroad thro
Resisting the reality of the HIV/AIDS epidemic.: J Fla Med Assoc. 1995 Apr;82(4):281-2. Unique Identifier : AIDSLINE MED/95294525; Shafran I; Gerscovich E
Prognostic value of adenosine deaminase compared to other markers for progression to acquired immunodeficiency syndrome among intravenous drug users.: J Med Virol. 1995 Feb;45(2):203-10. Unique Identifier : AIDSLINE MED/95294541; Casoli C; Lisa A; Magnani G; Starcich R; Fiaccadori F; Bertazzoni U; Zei G; Istituto di Patologia Medica, Universita di Parma, Italy.; This study was designed to determine the prognostic value of erythrocyte adenosine deaminase (ADA) as a possible indicator of progression to AIDS, and compare this with other known cellular and serological markers. At the end of a 3-year study, a cohort of 114 human immunodeficiency virus-1 (HIV-1) seropositive intrav
Detection of hepatitis C virus RNA in the cell fraction of saliva before and after oral surgery.: J Med Virol. 1995 Feb;45(2):223-6. Unique Identifier : AIDSLINE MED/95294544; Chen M; Yun ZB; Sallberg M; Schvarcz R; Bergquist I; Berglund HB; Sonnerborg A; Division of Clinical Virology, Karolinska Institute, Huddinge; Hospital, Sweden.; The presence of hepatitis C virus (HCV) RNA in serum, whole saliva, and saliva from the submaxillary glands was investigated before and after oral surgery. The presence of HCV RNA (positive and negative-strand RNA) was determined in serum and saliva by a nested polymerase chain reaction in 26 anti-HCV positive patient
Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant.: J Med Virol. 1995 Mar;45(3):288-92. Unique Identifier : AIDSLINE MED/95294555; Knox KK; Harrington DP; Carrigan DR; Department of Pathology, Medical College of Wisconsin, Milwaukee; 53226, USA.; Self-limited involvement of the central nervous system (CNS) is a relatively common complication of primary infection with human herpesvirus six (HHV-6) in normal children. We describe an HIV-infected infant who developed fulminant encephalitis as a complication of HHV-6 infection. Immunohistochemical staining of CNS
Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus.: J Med Virol. 1995 Mar;45(3):339-41. Unique Identifier : AIDSLINE MED/95294564; Arrazola MP; de Juanes JR; Ramos JT; Aragon AJ; Garcia de Codes A; Preventive Medicine Service, University Hospital 12 de Octubre,; Madrid, Spain.; A study was conducted to investigate the immunogenicity of a recombinant DNA hepatitis B vaccine in neonates and children of HIV-infected women. Immunization against hepatitis B consisted of three 10 micrograms doses of the vaccine administered on a 0-, 1- and 6-month schedule. The children were followed up for an ave
Anti-AIDS agents, 18. Sodium and potassium salts of caffeic acid tetramers from Arnebia euchroma as anti-HIV agents.: J Nat Prod. 1995 Mar;58(3):392-400. Unique Identifier : AIDSLINE MED/95294590; Kashiwada Y; Nishizawa M; Yamagishi T; Tanaka T; Nonaka G; Cosentino LM; Snider JV; Lee K; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599, USA.; Monosodium and monopotassium salts [2-4] of isomeric caffeic acid tetramers were isolated from Arnebia euchroma as anti-HIV agents. Mixtures of dipotassium and disodium salts [1] of a caffeic acid tetramer and dipotassium and potassium-sodium salts [5] of a caffeic acid tetramer glucoside were also isolated from the a
Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype.: J Pediatr. 1995 Jun;126(6):865-71. Unique Identifier : AIDSLINE MED/95294692; Husson RN; Lan Y; Kojima E; Venzon D; Mitsuya H; McIntosh K; Children's Hospital, Department of Pediatrics, Harvard Medical; School, Boston, Massachusetts 02115, USA.; OBJECTIVE: To evaluate immunologic and virologic correlates of vertical transmission of human immunodeficiency virus type 1 (HIV-1). DESIGN: Case-control study. PATIENTS: Women who were prospectively enrolled in a natural history study of HIV-1 infection in women and infants. Sixteen HIV-1-infected women whose infants
Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia.: J Oral Pathol Med. 1995 Mar;24(3):109-12. Unique Identifier : AIDSLINE MED/95294882; Mabruk MJ; Flint SR; Toner M; Leonard N; Sheils O; Coleman DC; Atkins GJ; Department of Microbiology, Moyne Institute, Trinity College,; Dublin, Republic of Ireland.; Epstein-Barr virus (EBV) DNA was detected by in situ hybridization at 3 sites of 30 samples taken from clinically normal lateral border of tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10 controls. The first positive case showed a thin layer of parakeratosis correlated with positive signals for E
Publication of clinical trial results: a clinician's view.: J R Soc Med. 1995;88 Suppl 24:12-6. Unique Identifier : AIDSLINE MED/95294946; Pinching AJ; Medical College of Saint Bartholomew's Hospital, West Smithfield,; London, UK.
The Institute of Medical Ethics: working parties and medical groups.: J Med Ethics. 1995 Feb;21(1):64. Unique Identifier : AIDSLINE MED/95294980
Researchers develop ceramic drug delivery system.: J Miss State Med Assoc. 1995 Apr;36(4):115-7. Unique Identifier : AIDSLINE MED/95294988
New sexually transmitted diseases treatment guidelines.: J Urol. 1995 Jul;154(1):209-13. Unique Identifier : AIDSLINE MED/95295066; Krieger JN; Department of Urology, University of Washington School of; Medicine, Seattle, USA.
Terms of engraftment: umbilical cord blood transplants arouse enthusiasm [news]: JAMA. 1995 Jun 21;273(23):1813-5. Unique Identifier : AIDSLINE MED/95295131; Stephenson J
From the Centers for Disease Control and Prevention. Update: trends in AIDS among men who have sex with men--United States, 1989-1994.: JAMA. 1995 Jun 21;273(23):1818, 1820. Unique Identifier : AIDSLINE MED/95295134
HIV incidence among injection drug users enrolled in a Los Angeles methadone program [letter]: JAMA. 1995 Jun 21;273(23):1831-2. Unique Identifier : AIDSLINE MED/95295139; Kerndt PR; Weber M; Ford W; Prevots DR; Lehman JS
Human immunodeficiency virus and acquired immunodeficiency syndrome: updating the MMWR file.: J Emerg Nurs. 1995 Feb;21(1):69-74; quiz 75-7. Unique Identifier : AIDSLINE MED/95295236; Danis D; Halm K
A tribute to Barb Fassbinder.: J Emerg Nurs. 1995 Feb;21(1):88-9. Unique Identifier : AIDSLINE MED/95295242; Herring JP
Differential cell count and lymphocyte subsets in bronchoalveolar lavage during pneumonia with and without peripheral neutropenia.: Lung. 1995;173(1):25-33. Unique Identifier : AIDSLINE MED/95295356; von Eiff M; Schlingheider O; Schulze F; Zuhlsdorf M; van de Loo J; Department of Internal Medicine, University of Munster, Federal; Republic of Germany.; One hundred immunocompromised HIV negative patients with microbiologically positive pneumonia underwent bronchoalveolar lavage (BAL) studies. Thirty cases showed peripheral neutropenia (
[The quantification of human immunodeficiency virus viremia in patients with rapid and slow progression of the disease]: Med Clin (Barc). 1995 Apr 15;104(14):530-4. Unique Identifier : AIDSLINE MED/95295385; Bravo R; Soriano V; Martin R; del Romero J; Dronda F; Gutierrez M; Martinez P; Valencia E; Moreno V; Laguna F; et al; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; BACKGROUND: The natural course of the human immunodeficiency virus type 1 (HIV-1) infection is very variable. The factors which appear to determine the speed of immunodeficiency progression are multiple, although the virulence of the predominant viral strain seems to be one the main factors. The plasmatic viremia in i
[CD4+ lymphocytes in patients with a Leishmania-HIV coinfection (letter; comment)]: Med Clin (Barc). 1995 Apr 15;104(14):556-7. Unique Identifier : AIDSLINE MED/95295392; Altes J; Salas A; Riera M; Vilallonga C
Cryptococcosis, AIDS, and clinical trials [comment]: Lancet. 1995 Mar 4;345(8949):530-1. Unique Identifier : AIDSLINE MED/95295419; Hay RJ; St John's Institute of Dermatology, UMDS, Guys Hospital, London,; UK.
Women as women with HIV [see comments]: Lancet. 1995 Mar 4;345(8949):531-2. Unique Identifier : AIDSLINE MED/95295420; Horton R
Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients [see comments]: Lancet. 1995 Mar 4;345(8949):548-52. Unique Identifier : AIDSLINE MED/95295427; Quagliarello VJ; Viscoli C; Horwitz RI; Department of Internal Medicine, Yale University School of; Medicine, New Haven, CT 06510, USA.; To evaluate whether oral fluconazole reduces the risk of a first episode of cryptococcal meningitis in HIV-infected patients, we conducted a case-control study of patients cared for in a university teaching hospital and two urban HIV-outpatient clinics. Cases consisted of HIV-infected patients with CD4 cell counts les
Spotlight on inhibitors of HIV protease [news]: Lancet. 1995 Mar 4;345(8949):576. Unique Identifier : AIDSLINE MED/95295437; Rowe PM
Treatment of Indian kala-azar with pentavalent antimony [letter; comment]: Lancet. 1995 Mar 4;345(8949):584. Unique Identifier : AIDSLINE MED/95295450; Arya SC
When to use fluconazole [letter; comment] [see comments]: Lancet. 1995 Mar 4;345(8949):584. Unique Identifier : AIDSLINE MED/95295451; Denning DW
Treatment of Indian Kala-azar with pentavalent antimony [letter; comment]: Lancet. 1995 Mar 4;345(8949):584-5. Unique Identifier : AIDSLINE MED/95295452; Domingo P; Ferrer S; Kolle L; Munoz C; Sambeat MA
Intestinal mycobacteria in African AIDS patients [letter]: Lancet. 1995 Mar 4;345(8949):585. Unique Identifier : AIDSLINE MED/95295453; Pankhurst CL; Luo N; Kelly P; Drobniewski F; Ngwenya B; Farthing MJ
Association of primary sclerosing cholangitis, thymoma and hypogammaglobulinemia.: Liver. 1995 Feb;15(1):53-5. Unique Identifier : AIDSLINE MED/95295522; Yoshioka R; Sato Y; Kogure A; Ohira H; Takagi T; Kuroda M; Miyata M; Obara K; Nishimaki T; Kasukawa R; Department of Internal Medicine II, Fukushima Medical College,; Japan.; A 64-year-old Japanese woman with thymoma has been suffering from diarrhea and increased alkaline phosphatase levels without jaundice. Her serum immunoglobulin levels of IgM and IgG were less than half of the normal levels, with an increase in CD8 (suppressor/cytotoxic) T cell percentage and a decrease in CD4 (helper)
The solution to the seven mysteries of AIDS: the 'Trojan horse'.: Med Hypotheses. 1995 Jan;44(1):1-9. Unique Identifier : AIDSLINE MED/95295579; Erlander SR; Erlander's Natural Products, Altadena, CA 91003, USA.; It is concluded that the sperm is the cause of AIDS but that HIV may slightly alter the symptoms of this disease, as compared to idiopathic CD4+ T-lymphocytopenia, or ICL, where the sperm, but not HIV, is assumed present. In the proposed mechanism, the sperm selectively accepts into its interior only macrophage-tropic
Preliminary evidence for idiotype-antiidiotype immune complexes cross-reactive with lymphocyte antigens in AIDS and lupus.: Med Hypotheses. 1995 Jan;44(1):20-7. Unique Identifier : AIDSLINE MED/95295582; Root-Bernstein RS; Department of Physiology, Michigan State University, East Lansing; 48824, USA.; Several investigators have proposed that autoimmunity may be induced by idiotype-antiidiotype antibody networks. It is generally assumed that the antiidiotype is produced in response to the idiotype, and therefore that autoimmune diseases have single antigenic initiators. The theory of multiple-antigen-mediated autoim
Isolation of HIV-1 from experimentally contaminated multidose local anaesthetic vials [see comments]: Med J Aust. 1995 May 15;162(10):513-5. Unique Identifier : AIDSLINE MED/95295597; Druce JD; Locarnini SA; Birch CJ; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital, Melbourne.; OBJECTIVE: To investigate the hypothesis that HIV can be transmitted via contamination of multidose vials of local anaesthetic solution through reuse of needles and syringes. DESIGN AND SETTING: Laboratory study. (1) By experiments with multidose vials and disposable needles and syringes, we identified a sequence of e
Confusion, cortical blindness and fever [clinical conference] [see comments]: Med J Aust. 1995 May 15;162(10):527-31. Unique Identifier : AIDSLINE MED/95295601; Sue CM; Morris JG; Leicester J; Farrell GC; Department of Neurology, Westmead Hospital, Sydney, N.S.W.
[Therapy of tuberculosis in the adult]: Med Klin. 1995 Apr 15;90(4):229-30. Unique Identifier : AIDSLINE MED/95295625; Schrappe M; Wassermann K; Kroegel C; Medizinische Klinik I, Albert-Ludwig-Universitat Freiburg.
Rare diseases, drug development, and AIDS: the impact of the Orphan Drug Act.: Milbank Q. 1995;73(2):231-52. Unique Identifier : AIDSLINE MED/95295637; Arno PS; Bonuck K; Davis M; Department of Epidemiology and Social Medicine, Montefiore; Medical Center/Albert Einstein College of Medicine, Bronx, NY; 10467-2490, USA.; The Orphan Drug Act provides public subsidies and incentives to spur the development of drugs for rare diseases--drugs that the private sector might otherwise consider unprofitable to produce. Although the act has achieved numerous successes, the high prices and extraordinary sales generated by some orphan drugs lead
The treatment of scabies with ivermectin.: N Engl J Med. 1995 Jul 6;333(1):26-30. Unique Identifier : AIDSLINE MED/95295757; Meinking TL; Taplin D; Hermida JL; Pardo R; Kerdel FA; Department of Dermatology and Cutaneous Surgery, University of; Miami School of Medicine, FL, USA.; BACKGROUND. Ivermectin is an anthelmintic agent that has been a safe, effective treatment for onchocerciasis (river blindness) when given in a single oral dose of 150 to 200 micrograms per kilogram of body weight. Anecdotal reports of improvement in patients who suffered from infestation with the mite Sarcoptes scabie
Hodgkin's disease and HIV infection [letter; comment]: N Engl J Med. 1995 Jul 6;333(1):65-6. Unique Identifier : AIDSLINE MED/95295773; Knopf KB; Locker GY
What causes wasting in AIDS? [editorial; comment]: N Engl J Med. 1995 Jul 13;333(2):123-4. Unique Identifier : AIDSLINE MED/95295788; Grunfeld C
Energy expenditure and wasting in human immunodeficiency virus infection [see comments]: N Engl J Med. 1995 Jul 13;333(2):83-8. Unique Identifier : AIDSLINE MED/95295805; Macallan DC; Noble C; Baldwin C; Jebb SA; Prentice AM; Coward WA; Sawyer MB; McManus TJ; Griffin GE; Division of Infectious Diseases, St. George's Hospital Medical; School, London, United Kingdom.; BACKGROUND. Increased expenditure of energy at rest has been considered a contributing factor to the negative energy balance and weight loss that occur in patients with human immunodeficiency virus (HIV) infection. However, the true determinant of energy balance is not resting but total energy expenditure. We sought t
Effect of amphotericin B on the lipids of five different strains of Cryptococcus neoformans.: Mycopathologia. 1994 Nov;128(2):85-9. Unique Identifier : AIDSLINE MED/95295811; Franzot SP; Hamdan JS; Department of Microbiology, Institute of Biological Sciences,; Federal University of Minas Gerais, Belo Horizonte, Brazil.; Cells of five strains of Cryptococcus neoformans were obtained for partial analysis of lipid composition. Quantitative analysis of lipids and sterols were completed, as well as qualitative analysis of sterols by thin-layer chromatography and by the ultraviolet spectra. Such determinations were made on cells cultured i
French journalism defended [letter; comment]: Nature. 1995 Jun 8;375(6531):444. Unique Identifier : AIDSLINE MED/95295818; Badou G; Bantmann B; Cardin H; Casteret AM; Malaurie G; Mazzolini A; Moliere H; Noel AP; Nothias JL; Parinaud F; et al
Cytomegalovirus sinusitis in a patient with acquired immunodeficiency syndrome.: Otolaryngol Head Neck Surg. 1995 Jun;112(6):750-3. Unique Identifier : AIDSLINE MED/95296153; Williams JD; Kieserman SP; Tavin E; Department of Otolaryngology-Head and Neck Surgery, New York Eye; and Ear Infirmary, NY 10003, USA.
Cardiovascular manifestations of pediatric HIV infection.: Nurs Clin North Am. 1995 Jun;30(2):291-316. Unique Identifier : AIDSLINE MED/95296198; Lane-McAuliffe EM; Lipshultz SE; Department of Cardiology, Children's Hospital, Boston,; Massachusetts, USA.; Infection with human immunodeficiency virus (HIV) has become a major pediatric health concern in the United States and around the world. Pediatric HIV infection is a multisystem illness that presents an ongoing challenge to practicing nurses. Most clinical cardiovascular diseases in ch
Adolescent sexual intercourse. Strategies for promoting abstinence in teens [see comments]: Postgrad Med. 1995 Jun;97(6):121-7, 132-4. Unique Identifier : AIDSLINE MED/95296231; Kay LE; Polyclinic Medical Center, Harrisburg, PA 17110, USA.; As sex, drugs, and rock n roll have given way to STDs, HIV, and AIDS, adolescent sex has become an increasingly high-risk behavior. Dr Kay strongly believes that primary care physicians can have a prominent role in educating teens and their parents about the consequences of premature sexual activity and in promoting
Vertebral osteomyelitis. How to differentiate it from other causes of back and neck pain [see comments]: Postgrad Med. 1995 Jun;97(6):147-8, 151-4. Unique Identifier : AIDSLINE MED/95296233; Strausbaugh LJ; Veterans Affairs Medical Center, Portland, OR 97207, USA.; Vertebral osteomyelitis, an uncommon infection, usually presents with the very common symptom of neck or back pain. Awareness of this disorder and its distinctive features aids physicians in prompt ordering of appropriate imaging studies, which usually lead to the diagnosis. Early diagnosis, identification of the infe
The pathology of AIDS.: Mod Pathol. 1995 Feb;8(2):199-217. Unique Identifier : AIDSLINE MED/95296278; Nash G; Said JW; Nash SV; DeGirolami U; Baystate Medical Center, Springfield, Massachusetts, USA.
Structural variety of arginine-rich RNA-binding peptides.: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5282-6. Unique Identifier : AIDSLINE MED/95296294; Tan R; Frankel AD; Department of Biochemistry and Biophysics, University of; California, San Francisco 94141, USA.; Arginine-rich domains are used by a variety of RNA-binding proteins to recognize specific RNA hairpins. It has been shown previously that a 17-aa arginine-rich peptide from the human immunodeficiency virus Rev protein binds specifically to its RNA site when the peptide is in an alpha-helical conformation. Here we show
Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5381-5. Unique Identifier : AIDSLINE MED/95296314; Bartz SR; Hohenwalter E; Hu MK; Rich DH; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin, Madison 53706, USA.; Analogs of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) with substitutions in positions 1, 4, 6, and/or 11 were rationally designed to possess substantially diminished or no immunosuppressive activity. When these compounds were assayed for their capacity to interfere with the replication of human imm
Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5461-4. Unique Identifier : AIDSLINE MED/95296330; Li CJ; Wang C; Friedman DJ; Pardee AB; Division of Cell Growth and Regulation, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, MA 02115, USA.; Infection by human immunodeficiency virus type 1 (HIV-1) causes acquired immunodeficiency syndrome (AIDS) after a long clinical latency. This disease is associated with a spectrum of cancers. Here we report that wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits th
Human immunodeficiency virus 1 reservoir in CD4+ T cells is restricted to certain V beta subsets.: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5563-7. Unique Identifier : AIDSLINE MED/95296351; Dobrescu D; Kabak S; Mehta K; Suh CH; Asch A; Cameron PU; Hodtsev AS; Posnett DN; Department of Medicine, Cornell University Medical College, New; York, NY 10021, USA.; The human immunodeficiency virus 1 (HIV-1) replicates more efficiently in T-cell lines expressing T-cell receptors derived from certain V beta genes, V beta 12 in particular, suggesting the effects of a superantigen. The targeted V beta 12 subset was not deleted in HIV-1-infected patients. It was therefore possible th
Vector-mediated delivery of a polyamide (peptide) nucleic acid analogue through the blood-brain barrier in vivo.: Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5592-6. Unique Identifier : AIDSLINE MED/95296357; Pardridge WM; Boado RJ; Kang YS; Department of Medicine, University of California, Los Angeles,; School of Medicine 90024, USA.; Polyamide (peptide) nucleic acids (PNAs) are molecules with antigene and antisense effects that may prove to be effective neuropharmaceuticals if these molecules are enabled to undergo transport through the brain capillary endothelial wall, which makes up the blood-brain barrier in vivo. The model PNA used in the pres
Managing the child infected with HIV.: Prim Care. 1995 Mar;22(1):23-50. Unique Identifier : AIDSLINE MED/95296448; Larson T; Bechtel L; Department of Pediatrics, University of Nevada School of; Medicine, Reno 89557-0046, USA.; Care of the HIV-infected/exposed infant and child is both routine and challenging. Routine well child care and immunizations are an important part of maintaining and monitoring health status. Challenges arise in the management of acute illnesses and the numerous crises that are experienced by the family caring for tha
RCMI International AIDS Symposium. AIDS in Hispanic and Other Minority Populations. San Juan, Puerto Rico, November 3-4, 1994. Abstracts.: P R Health Sci J. 1995 Mar;14(1):23-87. Unique Identifier : AIDSLINE MED/95296477
France. AIDS expert charged in HIV-blood case [news]: Science. 1995 Jun 16;268(5217):1563. Unique Identifier : AIDSLINE MED/95296686; Balter M
Can one type of HIV protect against another type? [news; comment]: Science. 1995 Jun 16;268(5217):1566. Unique Identifier : AIDSLINE MED/95296688; Cohen J
Significance of solitary and multiple esophageal ulcers in patients with AIDS.: South Med J. 1995 Jun;88(6):626-9. Unique Identifier : AIDSLINE MED/95296713; Martinez EJ; Nord HJ; Cooper BG; Department of Internal Medicine, University of South Florida; College of Medicine, Tampa, USA.; We endoscopically evaluated odynophagia and/or dysphagia in 23 patients with acquired immunodeficiency syndrome (AIDS). Eleven patients (48%) were found to have esophageal ulcers. Seven of them had deep, sharply demarcated, well-circumscribed ulcer craters with raised edges; in two the ulcer extended to the muscularis
Disseminated histoplasmosis in a patient from a nonendemic area who has acquired immunodeficiency syndrome.: South Med J. 1995 Jun;88(6):651-3. Unique Identifier : AIDSLINE MED/95296719; Munis A; Habte-Gabr E; Department of Internal Medicine, Hurley Medical Center/Michigan; State University, Flint 48503, USA.; Disseminated histoplasmosis is a serious opportunistic infection in patients with the acquired immunodeficiency syndrome (AIDS), often seen as the first manifestation of the syndrome. However, cases are reported almost exclusively from patients who live in or have traveled to endemic areas. We describe a case of disse
Confidentiality concerning HIV/AIDS status--the implications of the Appeal Court decision [see comments]: S Afr Med J. 1995 Mar;85(3):141-4. Unique Identifier : AIDSLINE MED/95296796; Dancaster JT; Dancaster LA; Department of Orthodontics, University of the Witwatersrand,; Johannesburg.; The Appellate Division recently overturned a Supreme Court judgement concerning the disclosure of a patient s HIV status by his general practitioner to another general practitioner and a dentist. This article examines the content of both judgements with particular reference to its implication for the medical professio
Use of saliva as an alternative to serum for HIV screening in Africa.: S Afr Med J. 1995 Mar;85(3):156-7. Unique Identifier : AIDSLINE MED/95296801; Luo N; Kasolo F; Ngwenya BK; du Pont HL; Zumla A; Department of Pathology and Microbiology, University Teaching; Hospital, Lusaka, Zambia.; Saliva has been recommended as a safe and effective alternative to serum for enzyme-linked immunosorbent assay (ELISA) for HIV antibodies in surveillance programmes in developing countries. We evaluated the use of saliva specimens for detection of HIV antibodies using three different commercially available ELISAs. Sal
Familial spread of HTLV-I in KwaZulu/Natal [letter]: S Afr Med J. 1995 Mar;85(3):186-7. Unique Identifier : AIDSLINE MED/95296821; Bhigjee AI; Bill PL; Madurai S; York D; Thaler D
Gossiping about an HIV patient can be costly [editorial; comment]: S Afr Med J. 1995 Mar;85(3):9. Unique Identifier : AIDSLINE MED/95296829
[Steady homosexual relationship and HIV infection]: Tidsskr Nor Laegeforen. 1995 May 20;115(13):1638-41. Unique Identifier : AIDSLINE MED/95296924; Eskild A; Magnus P; Thorvaldsen J; Petersen G; Seksjon for epidemiologi, Statens Institutt for Folkehelse, Oslo.; In order to study the relative impact of a steady homosexual relationship on the presence of HIV antibodies, a cross-sectional study was undertaken of 719 homosexual men in Oslo during the period of 1983-1987. 74/719 (10%) were HIV positive. 37/74 (50%) of the HIV positives and 185/645 (29%) of the HIV negatives were
Visceral leishmaniasis and HIV-1 co-infection in southern France.: Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):159-62. Unique Identifier : AIDSLINE MED/95296988; Rosenthal E; Marty P; Poizot-Martin I; Reynes J; Pratlong F; Lafeuillade A; Jaubert D; Boulat O; Dereure J; Gambarelli F; et al; Department of Internal Medicine, University Hospital, Nice,; France.; Between 1986 and 1993 visceral leishmaniasis (VL) was diagnosed in 50 adult patients with human immunodeficiency virus type 1 (HIV-1) infection (8 females, 42 males: 31 intravenous drug users, 11 homosexual or bisexual men, 6 heterosexual individuals, 2 blood recipients) from 5 hospital centres in southern
Ethiopian visceral leishmaniasis patients co-infected with human immunodeficiency virus.: Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):205-7. Unique Identifier : AIDSLINE MED/95297002; Berhe N; Hailu A; Wolday D; Negesse Y; Cenini P; Frommel D; Institute of Pathobiology, Addis Ababa University, Ethiopia.; This communication reports 7 Ethiopian visceral leishmaniasis (VL) patients co-infected with human immunodeficiency virus (HIV). The clinical and laboratory findings in 6 patients did not differ from classical VL. All patients had highly elevated anti-leishmanial antibody titres, determined by immunoglobulin G-based e
Serological responses to brucellosis in HIV-seropositive patients.: Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):228-30. Unique Identifier : AIDSLINE MED/95297011; Paul J; Gilks C; Batchelor B; Ojoo J; Amir M; Selkon JB; Public Health Laboratory, John Radcliffe Hospital, Oxford, UK.; Serial sera from 2 patients infected with the human immunodeficiency virus (HIV) type 1 attending a clinic in Nairobi, Kenya , and with blood cultures yielding Brucella melitensis, were tested by enzyme-linked immunosorbent assay for their serological response (Brucella-specific immu
Female genital schistosomiasis: a neglected risk factor for the transmission of HIV? [letter]: Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):237. Unique Identifier : AIDSLINE MED/95297013; Feldmeier H; Krantz I; Poggensee G
Evaluation of performance of reused HIVCHEK 1 + 2 test blocks which have shown negative result: a reliable method for rural hospital?: Trop Doct. 1995 Apr;25(2):54-5. Unique Identifier : AIDSLINE MED/95297055; Acaye GL; Ansaloni L; Tocalli E; Dr Ambrosoli Memorial Hospital, Kalongo, Kitgum District, Uganda.; The performance of the reusing of test membranes which have been used previously for negative tests for the detection of antibody to HIV (HIVCHEK 1 + 2 of Ortho Diagnostic Systems, Paris, France ) was evaluated under field conditions. The sensitivity and specificity of the reusing s
Erratic G-->A hypermutation within a complete caprine arthritis-encephalitis virus (CAEV) provirus.: Virology. 1995 Jun 1;209(2):297-303. Unique Identifier : AIDSLINE MED/95297130; Wain-Hobson S; Sonigo P; Guyader M; Gazit A; Henry M; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.; The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G-->A hypermutation. Rather than being a smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regi
Isolation of high-affinity RNA ligands to HIV-1 integrase from a random pool.: Virology. 1995 Jun 1;209(2):327-36. Unique Identifier : AIDSLINE MED/95297133; Allen P; Worland S; Gold L; Department of Molecular, Cellular and Developmental Biology,; University of Colorado at Boulder 80309-0347, USA.; We were able to isolate high-affinity RNAs from a random pool that binds to integrase protein from the human immunodeficiency virus-type 1 using the procedure now known as SELEX. Generally, the RNAs fell into three different classes in binding buffer containing 250 mM NaCl: group I class of molecules binds integrase w
Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.: Virology. 1995 Jun 1;209(2):347-57. Unique Identifier : AIDSLINE GENBANK/U18543; Fridell RA; Harding LS; Bogerd HP; Cullen BR; Howard Hughes Medical Institute, Durham, North Carolina, USA.; Transcriptional activation of HIV-1 gene expression by the viral Tat protein requires the interaction of a cellular cofactor with the Tat activation domain. This domain has been shown to consist of the cysteine-rich and core motifs of HIV-1 Tat and is functionally conserved in the distantly related Tat proteins of HIV
Transmissible retrovirus in Epstein-Barr virus-producer B95-8 cells.: Virology. 1995 Jun 1;209(2):374-83. Unique Identifier : AIDSLINE GENBANK/U23805; Sun R; Grogan E; Shedd D; Bykovsky AF; Kushnaryov VM; Grossberg SE; Miller G; Department of Molecular Biophysics and Biochemistry, Yale; University School of Medicine, New Haven, Connecticut 06520, USA.; Epstein-Barr virus (EBV) released from the B95-8 marmoset cell line has served as a prototype for biologic and biochemical studies of EBV. Here we identify and characterize a retrovirus carried by many cultures of B95-8 cells. The experiments were stimulated by the isolation of a cDNA clone from B95-8 cells in which s
Feline immunodeficiency virus (FIV)-specific cytotoxic T lymphocytes from chronically infected cats are induced in vitro by retroviral vector-transduced feline T cells expressing the FIV capsid protein.: Virology. 1995 Jun 1;209(2):390-9. Unique Identifier : AIDSLINE MED/95297140; Song W; Collisson EW; Li J; Wolf AM; Elder JH; Grant CK; Brown WC; Department of Veterinary Pathobiology, Texas A&M University,; College Station, USA.; We have previously reported the presence of feline immunodeficiency virus (FIV)-specific, major histocompatibility complex (MHC)-restricted cytolytic T lymphocytes (CTL) in experimentally FIV-infected cats. However, the fine specificity of the CTL and the role of individual FIV proteins in inducing FIV-specific CTL re
cis-acting regulatory elements in the bovine immunodeficiency virus long terminal repeat.: Virology. 1995 Jun 1;209(2):604-14. Unique Identifier : AIDSLINE MED/95297161; Fong SE; Pallansch LA; Mikovits JA; Lackman-Smith CS; Ruscetti FW; Gonda MA; Laboratory of Cell and Molecular Structure, Program Resources,; Inc./DynCorp, Frederick, Maryland, USA.; Functional cis-acting regulatory elements in the bovine immunodeficiency virus (BIV) long terminal repeat (LTR) were identified by deletion mapping and nuclear protein gel shift analysis using three BIV-infectible cell lines, Cf2Th, BLAC-20, and EREp. Deletion mapping studies indicated that putative NF-kappa B, GRE, A
Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity.: Virology. 1995 Jun 1;209(2):615-23. Unique Identifier : AIDSLINE MED/95297162; Yao XJ; Friborg J; Checroune F; Gratton S; Boisvert F; Sekaly RP; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de; Medecine, Universite de Montreal, Quebec, Canada.; The HIV-1-encoded Vpu protein induces a rapid and specific degradation of CD4 molecules in the endoplasmic reticulum (ER). In this study, Vpu-induced degradation of CD4 in the ER was investigated by quantitative immunoprecipitation of CD4 following cotransfection of COS-7 cells with CD4 and Vpu expressors in the prese
Comparison of the response to T-cell activation by integrated HIV-1 and HTLV-1 LTR-lacZ vectors.: Virology. 1995 Jun 1;209(2):633-6. Unique Identifier : AIDSLINE MED/95297164; Copeland KF; Hendrikx PJ; Haaksma AG; Fiering S; Van Lier R; Goudsmit J; Heeney JL; Laboratory of Viral Pathogenesis, Biomedical Primate Research; Centre, Rijswijk, The Netherlands.; Human Jurkat T-cell clones containing stably integrated HIV-1 LTR or HTLV-1 LTR/lacZ vectors were studied to compare the responses of integrated LTRs to T-cell activation. Responses were compared also with those obtained in parallel with Jurkat cells stably expressing lacZ under the control of the cellular enhancer el
Lack of pseudotype formation between human immunodeficiency virus type 1 and Epstein-Barr virus in productively coinfected B lymphoblastoid cell lines [published erratum appears in Virology 1995 Oct 1;212(2):757]: Virology. 1995 Jun 1;209(2):643-8. Unique Identifier : AIDSLINE MED/95297166; Van Kuyk R; Mosier DE; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037, USA.; Human immunodeficiency virus (HIV) can form pseudotypes with other enveloped viruses, including herpes simplex virus, when the two viruses coinfect the same cell. Pseudotypes between HIV and Epstein-Barr virus (EBV) have not been described. We observed unusually high levels of HIV-1 replication in SCID mice transplant
Fusogenic determinants of highly cytopathic subtype D Zairian isolate HIV-1 NDK.: Virology. 1995 Jun 1;209(2):649-53. Unique Identifier : AIDSLINE MED/95297167; De Mareuil J; Salaun D; Chermann JC; Hirsch I; Unite de Recherches sur les Retrovirus et Maladies Associees,; INSERM U322, Parc Scientifique et Technologique de Luminy,; Marseille, France.; Phenotypic characterization of subtype B strains of human immunodeficiency virus type 1 (HIV-1) indicates that the major determinants of their cytopathogenicity and tropism are contained in the gene coding for the envelope glycoprotein gp120, namely in its variable regions V1, V2, and V3. Recombinant viruses derived f
Analysis of ALV-based packaging cell lines for production of contaminant defective viruses.: Virology. 1995 Jun 1;209(2):671-5. Unique Identifier : AIDSLINE MED/95297171; Girod A; Cosset FL; Verdier G; Ronfort C; Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 106,; INRA, Universite Claude Bernard, Villeurbanne, France.; We have previously described avian leukosis virus-based packaging cell lines that express gag, pol, and env proteins from two transcomplementing genomes and produce helper-free stocks of retroviral vectors with different host ranges. In this report, we demonstrated that (i) despite the deletion of the psi packaging se
Mutations in the p53 tumor-suppressor gene are frequently associated with bovine leukemia virus-induced leukemogenesis in cattle but not in sheep.: Virology. 1995 Jun 1;209(2):676-83. Unique Identifier : AIDSLINE MED/95297172; Dequiedt F; Kettmann R; Burny A; Willems L; Department of Molecular Biology and Animal Physiology, Faculty of; Agronomy, Gembloux, Belgium.; To investigate the mechanisms of bovine leukemia virus (BLV)-induced leukemogenesis, we have examined the alterations of the p53 tumor-suppressor gene in sheep and in cattle. The sequences of the open reading frames as well as the intron/exon junctions of the ovine and bovine p53 genes were determined. Pathological sa
Cell-to-cell fusion, but not virus entry in macrophages by T-cell line tropic HIV-1 strains: a V3 loop-determined restriction.: Virology. 1995 Jun 1;209(2):696-700. Unique Identifier : AIDSLINE MED/95297176; Simmons G; McKnight A; Takeuchi Y; Hoshino H; Clapham PR; Virology Laboratory, Chester Beatty Laboratories, Institute of; Cancer Research, London.; T-cell lines chronically infected with laboratory adapted, T-cell tropic HIV-1 strains (RF, LAI, CBL-4, and NY5) induced syncytia after cocultivation with primary macrophages. Such fusion-competent strains, however, replicated inefficiently after cell-free infection of macrophage cultures. Evidence based on proviral D
[Bacterial, viral and fungal infections of the lungs in AIDS]: Zh Mikrobiol Epidemiol Immunobiol. 1995 Jan-Feb;(1):100-3. Unique Identifier : AIDSLINE MED/95297261; Pokrovskii VI; Godovannyi BA
African strategy. How to fight the human immunodeficiency virus [editorial]: Acta Obstet Gynecol Scand. 1995 May;74(5):325-9. Unique Identifier : AIDSLINE MED/95297323; Bergsjo P
Severe co-trimoxazole reaction in a man with AIDS.: J Am Board Fam Pract. 1995 Mar-Apr;8(2):130-3. Unique Identifier : AIDSLINE MED/95297383; Shepherd J; Shepherd C; Tonozzi C; Boysen E; Department of Family Medicine, University of Colorado, Denver; 80202, USA.; Although other drugs can be used in the prophylaxis and treatment of HIV-infected persons, family physicians will prescribe co-trimoxazole frequently. These providers need to recognize the overall increased frequency of adverse reactions to this drug in this population and the potential for severe hypersensitivity eff
Treatment of AIDS and HIV-related conditions--1995.: J Am Board Fam Pract. 1995 Mar-Apr;8(2):139-162. Unique Identifier : AIDSLINE MED/95297386; Goldschmidt RH; Dong BJ; Family Practice Residency Program, San Francisco General; Hospital, USA.
Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance.: Am J Med. 1995 Jun;98(6):566-71. Unique Identifier : AIDSLINE MED/95297476; Lee MH; Means RT Jr; Diagnostic Hematology Laboratory, University of Cincinnati; College of Medicine, Ohio 45267-0562, USA.; PURPOSE: To establish the frequency with which serum ferritin levels > or = 1,000 ng/mL occur in a general hospital population, and to determine the clinical significance of this finding. PATIENTS AND METHODS: All serum ferritin determinations performed between June 1992 and July 1993 at the University of Cincinnati M
Measuring HIV-1 infection among needle/syringe exchange attenders [letter; comment]: Am J Med. 1995 Jun;98(6):596-8. Unique Identifier : AIDSLINE MED/95297484; Green ST; Goldberg DJ; Frischer M; Cameron S; Taylor A; Gruer L
Case report of dapsone-related thrombocytosis in an AIDS patient [letter]: Am J Med. 1995 Jun;98(6):602. Unique Identifier : AIDSLINE MED/95297488; Wynn RF; Laing RB; Leen CL
Preventing mother-to-child transmission of human immunodeficiency virus infection [letter; comment]: Am J Obstet Gynecol. 1995 Jun;172(6):1951-3. Unique Identifier : AIDSLINE MED/95297574; Brocklehurst P
Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.: Am J Pathol. 1995 Jun;146(6):1542-55. Unique Identifier : AIDSLINE MED/95297603; Bofill M; Gombert W; Borthwick NJ; Akbar AN; McLaughlin JE; Lee CA; Johnson MA; Pinching AJ; Janossy G; Department of Clinical Immunology, Royal Free Hospital and School; of Medicine, London, United Kingdom.; Infection with human immunodeficiency virus 1 causes profound changes in the lymph nodes of infected patients. In particular, large numbers of CD8+CD45RO+ T cells infiltrate both the paracortex and the germinal centers. These cells contained the cytotoxic granule-associated protein TIA-1 but showed no detectable level
[Leishmaniasis and ENT]: An Otorrinolaringol Ibero Am. 1995;22(2):139-49. Unique Identifier : AIDSLINE MED/95297629; Carbonell Casasus J; Canovas Llorens DL; Soler Vilarrasa R; Mas Mercant S; Servicio de O.R.L. Hospital Son Dureta, Palma de Mallorca.; Three cases of the infrequent mucocutaneous Leishmaniasis, with nasal involvement in two of them and affection of the hypophrarynx and larynx in the other one are presented. We remark, in the case with laryngeal disease, that it was the onset of an AIDS in a patient unknown to be HIV+. Leishmaniasis of the larynx has
A novel method for analysis of viral proteinase activity encoded by hepatitis C virus in cultured cells.: Anal Biochem. 1995 Feb 10;225(1):113-20. Unique Identifier : AIDSLINE GENBANK/D28816; Hirowatari Y; Hijikata M; Shimotohno K; National Cancer Center Research Institute, Tokyo, Japan.; We developed a novel method for analysis of hepatitis C viral proteinase activity in cultured cells, in which the proteinase activity was measured as the enhancement of reporter gene expression. In this system, plasmids encoding a reporter gene, the enzyme gene, and the substrate gene were simultaneously transfected i
Codelivery to mammalian cells of a transcriptional factor with cis-acting element using cationic liposomes.: Anal Biochem. 1995 Feb 10;225(1):89-93. Unique Identifier : AIDSLINE MED/95297709; Farhood H; Gao X; Barsoum J; Huang L; Department of Pharmacology, University of Pittsburgh, School of; Medicine, Pennsylvania 15261, USA.; The human immunodeficiency virus-1 transactivator protein (tat) was codelivered efficiently with a reporter gene under the control of a tat-responsive DNA element using different formulations of cationic liposomes. Expression of a tat-responsive reporter gene was induced by incubating cells with a mixture of purified
Esophageal ulceration in human immunodeficiency virus infection. Causes, response to therapy, and long-term outcome [see comments]: Ann Intern Med. 1995 Jul 15;123(2):143-9. Unique Identifier : AIDSLINE MED/95297746; Wilcox CM; Schwartz DA; Clark WS; Emory University School of Medicine, Atlanta, Georgia, USA.; OBJECTIVE: To determine the causes of esophageal ulceration, the response rate to currently available therapies, and the long-term outcome in patients with human immunodeficiency virus (HIV) infection. DESIGN: Prospective cohort study. SETTING: An urban county hospital. PATIENTS: Consecutive patients with HIV infectio
Clarithromycin therapy for Mycobacterium avium complex bacteremia [letter; comment]: Ann Intern Med. 1995 Jul 15;123(2):154; discussion 155. Unique Identifier : AIDSLINE MED/95297749; Musher DM
Clarithromycin therapy for Mycobacterium avium complex bacteremia [letter; comment]: Ann Intern Med. 1995 Jul 15;123(2):154-5. Unique Identifier : AIDSLINE MED/95297751; van der Meer JT; Danner SA
The vasculopathy of varicella-zoster virus encephalitis.: Ann Neurol. 1995 Jun;37(6):784-90. Unique Identifier : AIDSLINE MED/95297772; Amlie-Lefond C; Kleinschmidt-DeMasters BK; Mahalingam R; Davis LE; Gilden DH; Department of Neurology, University of Colorado Health Sciences; Center, Denver 80262, USA.; Varicella-zoster virus (VZV) encephalitis has become more prevalent in the era of acquired immunodeficiency syndrome and other immunosuppressive diseases and poses diagnostic and therapeutic challenges for clinicians, radiologists, and pathologists. Six cases studied at our institutions shed light on the patterns and
Leukocytoclastic vasculitis following staphylococcal protein A column immunoadsorption therapy. Two cases and a review of the literature.: Arch Dermatol. 1995 Jun;131(6):707-9. Unique Identifier : AIDSLINE MED/95297854; Arbiser JL; Dzieczkowski JS; Harmon JV; Duncan LM; Department of Dermatology, Massachusetts General Hospital and; Harvard Medical School, Boston, USA.; BACKGROUND: Protein A immunoadsorption is a novel therapy for the treatment of diseases mediated by pathogenic autoantibodies. This procedure consists of circulating patients plasma through a column containing staphylococcal protein A, which binds to the Fc portion of IgG, enabling removal of IgG. Presently, protein
Sezary's syndrome and human immunodeficiency virus infection [letter]: Arch Dermatol. 1995 Jun;131(6):739-41. Unique Identifier : AIDSLINE MED/95297868; Berger TG; Kerschmann RL; Roth R; Schulze K; Zackheim HS
National trends in the concurrence of tuberculosis and acquired immunodeficiency syndrome.: Arch Intern Med. 1995 Jun 26;155(12):1281-6. Unique Identifier : AIDSLINE MED/95297889; Burwen DR; Bloch AB; Griffin LD; Ciesielski CA; Stern HA; Onorato IM; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, Ga., USA.; BACKGROUND: Elucidation of the relationship between tuberculosis (TB) and the acquired immunodeficiency syndrome (AIDS) is needed to help predict the future course of these two epidemics. We examined nationwide trends in TB and AIDS occurring in the same individual. METHODS: Health departments in the 50 states, Distri
Temporal trends of incident human immunodeficiency virus infection in a cohort of injecting drug users in Baltimore, Md.: Arch Intern Med. 1995 Jun 26;155(12):1305-11. Unique Identifier : AIDSLINE MED/95297892; Nelson KE; Vlahov D; Solomon L; Cohn S; Munoz A; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Md., USA.; OBJECTIVE: To measure the temporal trends in the incidence of infection with human immunodeficiency virus in a cohort of injecting drug users in Baltimore, Md, between 1988 and 1992. DESIGN: Study subjects were screened for antibodies to human immunodeficiency virus by enzyme-linked immunosorbent assay and confirmed w
Serological studies of bovine leukaemia virus infection in Queensland beef cattle.: Aust Vet J. 1995 Feb;72(2):71-2. Unique Identifier : AIDSLINE MED/95297973; Ward MP
HIV-1 gp120 produces DNA fragmentation in the cerebral cortex of rat.: Biochem Biophys Res Commun. 1995 Jun 6;211(1):130-6. Unique Identifier : AIDSLINE MED/95298012; Bagetta G; Corasaniti MT; Berliocchi L; Navarra M; Finazzi-Agro A; Nistico G; Department of Neuroscience, University of Cagliari, Italy.; In the present experiments we have used morphological techniques to study the neuropathological profile of the brain of rats after intracerebroventricular (i.c.v.) injection of recombinant HIV-1 gp 120. Using brain cryostat sections (10 microns) from rats treated with a single, daily dose of gp120 (100 ng/rat) given f
Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.: Biochem Biophys Res Commun. 1995 Jun 6;211(1):159-65. Unique Identifier : AIDSLINE MED/95298017; Sham HL; Zhao C; Marsh KC; Betebenner DA; Lin S; McDonald E; Vasavanonda S; Wideburg N; Saldivar A; Robins T; et al; Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.; A series of novel pseudo-symmetrical and unsymmetrical inhibitors based on the backbone modification of a peptidomimetic were synthesized and found to be highly potent inhibitors of t