1995

Physician heal thyself : the Charlie Mraz story. [videorecording]: Hartland 4-Corners, Vt. : American Apitherapy Society, [1993] 1 videocassette (38 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9507408; (Producer) This is the compelling story of Charlie Mraz, teacher and leader, pioneer of Bee Venom Therapy and advocate for returning health care treatment into hands of his patients. By implementing bee stings applied to pressure points much like Chinese acupuncture, Charlie Mraz has developed a treatment that often
Caring for persons with AIDS : a guide for home care aides. [videorecording]: [St. Louis, Mo.] : Mosby-Year Book, cl994 1 videocassette (25 min.) : sd., col. ; 1/2 in (Mosby's continuing health care education video series) Unique Identifier : AIDSLINE AV/9502113
Oral and cutaneous manifestations of HIV. [interactive multimedia]: Norwood, MA : SilverPlatter Education, c1995 1 computer optical disc : sd., col. ; 4 3/4 in Unique Identifier : AIDSLINE AV/9513127; Johnson RA; Kane KS; Haimowitz J; (Producer) Current estimates are that 1.2 million persons are infected with the human immunodeficiency virus (HIV) in the United States . By the year 2000, the projection is that up to 120 million will have become infected worldwide. Nearly all persons with HIV disease experience ora
[Il:sole malato : viaggio nella paura dell'AIDS.] 1. ed.: Milano : A. Mondadori, 1987 279 p (I Libri di Biagi) Unique Identifier : AIDSLINE CAT/9402000; Biagi E
[Prevencion del SIDA en el Ecuador.]: [Ecuador : s.n., 1988?] (Quito : Productores Graficos) 181 p. : ill., ports Unique Identifier : AIDSLINE CAT/9423889; Troncoso T. H
Avoidance of discrimination in relation to HIV-infected people and people with AIDS : the Forty-first World Health Assembly adopted resolution WHA41.24 in Geneva on 13 May 1988 = Non-discrimination a l'egard des personnes infectees par le VIH et des sideens : la Quarante et Unieme Assemblee mondiale de la Sante a adopte la resolution WHA41.24 a Geneve le 13 mai 1988.: Geneva : World Health Organization Global Programme on AIDS, [1988] [2] p Unique Identifier : AIDSLINE CAT/9510848
Consensus statement on accelerated strategies to reduce the risk of transmission of HIV by blood transfusion : Geneva, 20-22 March 1989.: Geneva : World Health Organization, Global Programme on AIDS, Health Laboratory Technology Unit, [1989] [4] p Unique Identifier : AIDSLINE CAT/9510846
Resolution WHA42.34 of the Forty-Second World Health Assembly : nongovernmental organizations and the global strategy for the prevention and control of AIDS, Geneva, 19 May 1989.: Geneva : World Health Organization, Global Programme on AIDS, [1989] [4] p Unique Identifier : AIDSLINE CAT/9510849
San Francisco AIDS Foundation Speakers Bureau manual. Rev.: [San Francisco, Calif.?] : The Foundation, [1990] 73 P Unique Identifier : AIDSLINE CAT/9400448; Camacho M; Schwartz R
[Bilan des connaissances sur l'epidemie du SIDA et de l'infection au VIH au Quebec.]: Montreal : Centre d'etudes sur le SIDA, Dep. de sante communautaire, Hopital general de Montreal, [1991] vii, 89 p Unique Identifier : AIDSLINE CAT/9431510; Remis RS
May God and the community help us all : results of a survey of HIV-positive and high risk untested health care workers.: San Francisco, CA : Medical Expertise Retention Program, [c1991] (1995 printing) 11 p. : ill Unique Identifier : AIDSLINE CAT/9514417; Schatz B
Counselling guidelines and policies.: [Malawi] : AIDS Control Programme, Ministry of Health, Malawi, [1992] 22 p Unique Identifier : AIDSLINE CAT/9512391
[O:trabalho cotidiano com a AIDS relatorio da etapa - 1, A situacao dos profissionais e problematizacao da AIDS :. as representacoes dos profissionais de saude em uma unidade hospitalar.]: Sao Paulo : Instituto de Infectologia Emilio Ribas, [1992] 1 v. (various foliations) : ill Unique Identifier : AIDSLINE CAT/9506489
Communicating about AIDS : a training manual.: Harare : Zimbabwe AIDS Network in association with UNICEF, c1993 v, 71 p. : ill Unique Identifier : AIDSLINE CAT/9511467; Laver S
[Memoria del 1er. Simposio Internacional de la Iglesia Catolica sobre el SIDA.]: [La Paz] : Caritas Boliviana, [1993] 141 p. : ill., ports Unique Identifier : AIDSLINE CAT/9506250
HIV/AIDS.: [Rockville, Md.?] : U.S. Dept. of Health and Human Services, Public Health Service, Health Resources and Services Administration, Bureau of Health Resources Development, [1993?] 45 p (DHHS publication ; no. HRSA-94-023) Unique Identifier : AIDSLINE CAT/9507549
[MTS-SIDA, quels risques pour nos jeunes? : resultats d'une enquete aupres des jeunes de 15-19 ans du territoire du DSC-HHR.]: [Quebec] : Dep. de sante communautaire, Hopital du Haut-Richelieu, c1993 vii, 45 leaves : ill Unique Identifier : AIDSLINE CAT/9504281; Bellerose C
[Wirklichkeitskonstruktionen und Selbstkonzepte HIV-Infizierter unterschiedlicher Betroffenengruppen.]: Munster : LIT, [1994] 142 p. : ill (Fortschritte der Psychologie ; Bd. 12) Unique Identifier : AIDSLINE CAT/9504043; Meyer zu Altenschildesche M
Interactions between retroviruses and herpesviruses.: Singapore ; River Edge, NJ : World Scientific Pub., c1994 xi, 122 p. : ill Unique Identifier : AIDSLINE CAT/9506438; Kung HJ; Wood C
HIV/AIDS in sub-Saharan Africa : demographic and socio-economic implications.: Nairobi, Kenya : African Population and Environment Institute with assistance from Japan International Cooperation Agency, Population Education Promotion Project, c1994 38 p. : ill (African population paper ; no. 3) Unique Identifier : AIDSLINE CAT/9512305; Anarfi JK
School health education to prevent AIDS and STD : a resource package for curriculum planners.: [Geneva] : World Health Organization, 1994 3 v. : ill Unique Identifier : AIDSLINE CAT/9511837
AIDS and the eye. 1st ed.: New Orleans, LA : Contact Lens Association of Ophthalmologists, c1995 154 p. : ill Unique Identifier : AIDSLINE CAT/9510694; Stenson S
TASO Uganda-- the inside story : participatory evaluation of HIV/AIDS counselling, medical and social services, 1993-1994.: Kampala, Uganda : The Aids Support Organization (TASO), c1995 xv, 88 p. : ill Unique Identifier : AIDSLINE CAT/9510807
HIV/AIDS : what health professionals need to know. 4th ed.: Miami, Fla. (P.O. Box 163200, Miami 33116-3200) : Health Studies Institute, c1995 135 p. : ill Unique Identifier : AIDSLINE CAT/9510272; Brown SK; Schulman J
People with HIV and those who help them : challanges, integration, intervention.: Binghamton, N.Y. : Haworth Press, c1995 xi, 245 p. : ill (Haworth social work practice) Unique Identifier : AIDSLINE CAT/9510716; Shelby RD
The:second decade of AIDS : a mental health practice handbook.: New York : Hatherleigh Press, c1995 iii, 313 p. : ill Unique Identifier : AIDSLINE CAT/9508510; Odets W; Shernoff M
AIDS and the impact of cognitive impairment : a treatment guide for mental health providers.: San Francisco, CA : AIDS Health Project, University of California San Francisco, 1995 (UCSF AHP monograph ; no. 1) Unique Identifier : AIDSLINE CAT/9513340; Zeifert P; Leary M; Boccellari AA
AIDS and HIV infection in the African-American community : hearing before the Human Resources and Intergovernmental Relations Subcommittee of the Committee on Government Operations, House of Representatives, One Hundred Third Congress, second sesson, September 16, 1994. [microform]: Operations. Human Resources and Intergovernmental Relations Subcommittee Washington : U.S. G.P.O. : For sale by the U.S. G.P.O., Supt. of Docs., Congressional Sales Office, 1995 iv, 154 p. : ill Unique Identifier : AIDSLINE CAT/9513732
The:AIDS epidemic : social dimensions of an infectious disease.: Boulder : Westview Press, 1995 xv, 288 p. : ill Unique Identifier : AIDSLINE CAT/9511330; Rushing WA
AIDS in post-communist Russia and its successor states.: Aldershot ; Brookfield, Vt. : Avebury, c1995 xvi, 216 p. : ill Unique Identifier : AIDSLINE CAT/9510731; Williams C
Building the capacity for an oral health response to the global HIV pandemic : principles for developing a country-specific approach.: Geneva : Oral Health Programme, World Health Organization, 1995 47 p. : ill Unique Identifier : AIDSLINE CAT/9510844; Nowjack-Raymer R
Physicians, nurses, and AIDS : findings from a national study.: [Rockville, Md. : Agency for Health Care Policy and Research ; Springfield, Va. : Available from NTIS, 1995] iv, 19 p Unique Identifier : AIDSLINE CAT/9510950; Colombotos J
Responding to AIDS : the healthcare professional's guide to legal issues & responsibilities.: Chicago, Ill. : Probus Pub., c1995 xi, 228 p Unique Identifier : AIDSLINE CAT/9510695; Tomes JP
The:AIDS challenge : breaking through the boundaries.: Westport, Conn. : Auburn House, 1995 xix, 152 p Unique Identifier : AIDSLINE CAT/9512453; O'Brien ME
Hidden in the blood : a personal investigation of AIDS in the Yucatan.: New York : Columbia University Press, c1995 xviii, 168 p (Between men--between women) Unique Identifier : AIDSLINE CAT/9512449; Wilson C
Ryan White Care Act reauthorization : hearing of the Committeeon Labor and Human Resources, United States Senate, One Hundred Fourth Congress, first session, on S. 641 to reauthorize the Ryan White Care Act of 1990, and for other purposes, February 22, 1995. [microform]: Resources Washington : U.S. G.P.O. : For sale by the U.S. G.P.O., Supt. of Docs., Congressional Sales Office, 1995 iv, 153 p. : ill Unique Identifier : AIDSLINE CAT/9514609
Fast, complete and persistent eradication of papilloma warts as additional activity of an anti-infective against RNA viruses (Meeting abstract).: Experientia; 50:A26 1994. Unique Identifier : AIDSLINE ICDB/95611721; Wirth-Bronkowska LE; Wirth UV; aiRVi-Institute, Hohenweg 7, CH-5426 Lengnau; Originally an anti-infectious drug against RNA viruses (aiRVi) was developed. Two different entities such as a biological and a chemical activity unit are necessary for efficiency of aiRVi. This antiviral drug could be used for disinfection, prevention and local therapy of RNA virus infections. Model systems will be d
An 'information-intensive' strategy for drug discovery in cancer and AIDS: relating cell cycle factors to patterns of drug activity (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1813 1995. Unique Identifier : AIDSLINE ICDB/95609588; Myers TG; Weinstein JN; Raghavan K; Buolamwini J; Anderson NL; O'Connor P; Kohn KW; Scudiero DA; Monks AP; Friend S; et al; Devel. Therapeutics Program DCT, NCI, Bethesda, MD 20892; The NCI Developmental Therapeutics Program screens more than 10,000 compounds a year against a panel of 60 human cancer cell lines in vitro. A compound s signature pattern of relative activity against the various cell lines has been shown to contain unexpectedly rich information about its mechanisms of action at the
Preclinical toxicity evaluation of beta-F-ddA in the rat and dog (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2184 1995. Unique Identifier : AIDSLINE ICDB/95609959; Tomaszewski JE; Schweikart KM; Wilkinson GE; Graves S; Mahon C; Toft J; Yarrington J; Placke ME; NCI, Bethesda, MD 20892; The safety and toxicity of beta-F-ddA, an anti-HIV, acid-stable, purine dideoxynucleoside was evaluated in preclinical studies. When beta-F-ddA was administered orally on a bid schedule to the rat, 1000 mg/kg/day produced mild cardiotoxicity. Oral doses up to 500 mg/kg/day were nontoxic in the dog when administered on
Membrane permeation characteristics of the structurally related anti-HIV agents 1592U89 and (-)-carbovir in human erythrocytes and human T-lymphoblastoid CD4+ CEM cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2211 1995. Unique Identifier : AIDSLINE ICDB/95609986; Mahony WB; Domin BA; Prus KL; Zimmerman TP; Wellcome Research Laboratories, Research Triangle Park, NC 27709; 1592U89 ((1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclope- ntene-1-methanol) is a carbocyclic guanosine analog that is currently in Phase I clinical trials for treatment of human immunodeficiency virus infection. Structurally, 1592U89 and (-)-carbovir (CBV) differ only at the 6-position of the nucleoba
Delivery of 2',3'-dideoxyinosine via intratracheal instillation (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2408 1995. Unique Identifier : AIDSLINE ICDB/95610182; Gao X; Wientjes MG; Jurcisek JA; Au JL; College of Pharmacy, Ohio State Univ., Columbus, OH 43210; We have shown that the low and variable oral bioavailability (average of 17%, range of 8-23%) of the anti-AIDS drug, 2 ,3 -dideoxyinosine (ddI), in rats is primarily due to its first-pass elimination in gastric acid and by intestinal flora. This study evaluated whether the intratracheal administration route provides a
Hydroxyurea (HU) increases activation of 2',3'-dideoxycytidine (ddC) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2410 1995. Unique Identifier : AIDSLINE ICDB/95610184; Agarwal RP; He J; Bansal M; Gupta V; Medical Oncology (R-71), Univ. of Miami School of Medicine,; Miami, FL 33136; ddC , one of the most potent inhibitors of HIV replication, exerts its anti-HIV effect through its 5 -triphosphate, ddCTP. We have examined the effect of HU on ddCTP formation from ddC. Following incubation of H9 cells (human lymphocytic cell line) wit
In vivo stability, pharmacokinetics, and metabolism of a 'hybrid' oligonucleotide phosphorothioate in rats (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A2450 1995. Unique Identifier : AIDSLINE ICDB/95610224; Lu Z; Zhao H; Diasio RB; Habus I; Jiang Z; Agrawal S; Zhang R; Dept. of Pharmacol. and Toxicol., Univ. of Alabama, Birmingham,; AL 35294; A hybrid oligonucleotide phosphorothioate, containing segment of oligodeoxynucleotide phosphorothioate flanked at 5 - and 3 -end by 2 -o-methyl oligoribonucleotide phosphorothioates, is found to be more active as anti-HIV agent than their oligodeoxynucleotide phosphorothioate counterpart. In the present study, pharm
Drug synergism by nucleoside analog drugs against HIV-RT based on multiple inhibitor kinetics (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A1720 1995. Unique Identifier : AIDSLINE ICDB/95609495; Periclou AP; Solorzano MM; Avramis VI; Div. of Hematology, USC School of Medicine, Los Angeles, CA 90027; Azidothymidine ( AZT ) and didanosine (ddI) have been shown to be synergistic against HIV in T-cell lines. We have examined the theoretical kinetics of a single enzyme (HIV-RT) with multiple substrates in the presence of one or more inhibitors. Based on
Inhibitors of angiogenesis and metastasis: preclinical and early clinical studies (Meeting abstract).: Ann Oncol; 5(Suppl 5):A014 1994. Unique Identifier : AIDSLINE ICDB/95611689; Pluda JM; NCI, Bethesda, MD; Angiogenesis and metastasis are tumor-related processes that are interrelated. Angiogenesis is required for the growth of tumors beyond a certain size. The invasion of surrounding tissue by tumor and the establishment and growth of distant metastatic foci also requires angiogenesis. Certain critical events that are re
Management of HIV-associated esophageal disease. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Mar;7(3):19-22. Unique Identifier : AIDSLINE AIDS/95700062; Belitsos PC; Johns Hopkins University, AIDS Service, Baltimore, MD.; Esophageal conditions due to fungal, ulcerative, and neoplastic causes often signal the onset of symptomatic HIV infection. Most cases are fungal and due to Candida albicans, which is characterized by esophageal inflammation causing pain on swallowing (dysphagia and odynophagia). Ulcerative esophageal disease is commo
Combination 3TC/AZT therapy shows promise. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Mar;7(3):22. Unique Identifier : AIDSLINE AIDS/95700063; The nucleoside reverse transcriptase inhibitor 3TC (lamivudine) appears to induce unusually prolonged HIV suppression when used in combination with AZT , according to the results of fo
Intolerable pruritis in an HIV-infected man. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Mar;7(3):23, 26. Unique Identifier : AIDSLINE AIDS/95700064; Zuger A; Nine out of ten HIV-infected people suffer from dermatologic complaints. Frequently, the morphology of HIV-associated skin lesions is characteristic enough for the clinician to construct an initial diagnosis and initiate a reasonable course of treatment until the diagnosis can be confirmed. However, HIV-associated pru
Finding suggests AZT therapy may help prevent occupational HIV infection. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):45-7. Unique Identifier : AIDSLINE AIDS/95700222; A study of health care workers exposed to HIV-contaminated blood indicates that preventive zidovudine ( AZT , Retrovir) therapy helped protect them from infection. The abstract for this unpublished study, conducted by the Centers for Disease Control and
Anergy tests draw strong reaction from experts. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):47-9. Unique Identifier : AIDSLINE AIDS/95700223; After growing controversy about the usefulness and effectiveness of anergy testing, the Centers for Disease Control and Prevention (CDC) may change its four-year-old recommendation that all HIV-positive people at risk for Tuberculosis (TB) be tested for anergy at the time of their TB skin test. Anergy, a condition in
Management of late-stage AIDS grows more complex. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):50-2. Unique Identifier : AIDSLINE AIDS/95700224; The question of what to do for patients with late-stage AIDS becomes more complicated as new research reinforces the value of early treatment and prophylaxis for HIV patients. Decisions ranging from cost and quality of life to toxicity and multiple drug interactions all must be taken into account. Pneumocystis carinii
Researchers seek clues to long-term survival. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):52-4. Unique Identifier : AIDSLINE AIDS/95700225; As many as 12 percent of HIV-infected homosexual men in the United States could remain AIDS-free for 20 years after seroconversion, and the median length of survival for children with AIDS may now be as high as eight years, according to several new studies presented at a national confe
HIV conference spotlights women's concerns. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):54-7. Unique Identifier : AIDSLINE AIDS/95700226; The HIV Infection in Women: Setting a New Agenda conference in Washington, DC, brought together researchers, providers, and HIV- positive women to discuss AIDS among women. The U.S. Public Health Service announced draft guidelines on counseling and testing of all pregnant women for HIV. These guideline were made in re
Assessing the risks for perinatal infection. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):56. Unique Identifier : AIDSLINE AIDS/95700227; The Centers for Disease Control and Prevention (CDC) recently conducted a review of 5,554 cases of children with perinatally acquired AIDS through December 1994 in order to determine the risks of perinatally acquired AIDS. CDC epidemiologist Teresa Hammett reported at the HIV Infection in Women: Setting A New Agenda c
Framework for counseling pregnant women presented. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):57-8. Unique Identifier : AIDSLINE AIDS/95700228; At a recent conference, the Health Resources and Services Administration (HRSA) presented guidelines on how health care providers can implement guidelines for counseling and testing of all pregnant women. At the February, 1995, national meeting in Washington, D.C. on women and HIV, sponsored by the National Institutes
Tuberculosis rising in areas with high HIV rates. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):58-9. Unique Identifier : AIDSLINE AIDS/95700229; The incidence of tuberculosis (TB), particularly multidrug-resistant TB, is rising among HIV-infected men and women, showing that diagnosis is critical to prevention and treatment of the disease. A speaker at the national conference on HIV infection in women, sponsored by the National Institutes of Health in Washingto
Some HIV clinics changing protocols on anergy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Alert. 1995 Apr;10(4):suppl 1-2. Unique Identifier : AIDSLINE AIDS/95700230; The Centers for Disease Control and Prevention (CDC) has advised health care workers to evaluate HIV-positive people for delayed-type hypersensitivity (DTH) anergy at the time of PPD (purified protein derivative) testing. However, controversy remains among those that feel anergy testing is either unnecessary or inaccu
Two key programs are kept intact, but HOPWA's fate remains uncertain. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):1, 10. Unique Identifier : AIDSLINE AIDS/95700231; The House of Representatives, at press time, was scheduled to vote on an amendment that would restore the full $186 million Housing Opportunities for People with AIDS (HOPWA) program appropriation for the current fiscal year. Advocacy groups became encouraged to save HOPWA since a recent legislative victory preserved
Forthcoming study says 3 of 4 new HIV infections are drug-related. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):1-2. Unique Identifier : AIDSLINE AIDS/95700232; According to an unpublished study by the Centers for Disease Control and Prevention (CDC), drug use is linked to nearly three-quarters of new HIV infections. Many of the infections are a result of sharing contaminated needles, but an increasing number are linked to crack cocaine addicts and other drug users who contra
Texas hair salon settles suit while another faces EEOC action. Equal Employment Opportunity Commission. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):2. Unique Identifier : AIDSLINE AIDS/95700233; The Equal Employment Opportunity Commission (EEOC) has filed suit against the nationally based Regis Corporation after hair stylist John Doe was fired shortly after his employer discovered he was HIV-positive. According to EEOC officials, Regis claimed that John Doe was fired for failing to attend a mandatory training
Court puts onus on doctors to warn patients about HIV status. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):3-4. Unique Identifier : AIDSLINE AIDS/95700234; Associate Justice Miriam A. Vogel, in a California appeals court, stated that doctors have an obligation to tell infected patients that they have a contagious disease so that patients and people around them can avoid spreading the illness. A decade ago, physician Eric Fonklesrud of the University of California (UCLA)
Rebuked by judge, Chicago settles suit charging police with job bias. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):4-5. Unique Identifier : AIDSLINE AIDS/95700235; To settle a lawsuit brought by two HIV-positive job applicants, the Chicago Police Department has agreed to stop testing police recruits for HIV. According to Geoffrey Kors, American Civil Liberties Project (a branch of the American Civil Liberties Union), HIV status has no bearing on a person s ability to be an effec
Florida judge nullifies adoption by HIV-positive parents. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):5. Unique Identifier : AIDSLINE AIDS/95700236; Circuit Judge Horace Andrews has ruled that a three-year-old girl will be removed from her adoptive parents care because they are infected with HIV. The girl, Elizabeth, will live with her adoptive father s parents rather than be placed for adoption with a stranger. The judge said he had to decide whether it would be
Lawsuit against Mason Tenders is heading toward a quiet finale. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):6. Unique Identifier : AIDSLINE AIDS/95700237; The June 1993 case challenging Mason Tenders District Council Welfare Fund s decision to exclude coverage of AIDS-related expenses incurred by union members enrolled in its health and welfare fund seems to have faded into the background. This is an important case because it is the Equal Employment Opportunity Commissi
Lawsuit charges New York City is denying basic AIDS services. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):7-8. Unique Identifier : AIDSLINE AIDS/95700238; Three AIDS advocacy groups have filed suit against New York City s Division of AIDS Services. This suit is the first of its kind to charge that a government agency failed to meet the American s with Disabilities Act s (ADA) requirement of equal access to benefits and services. Thousands of people are going without bas
Six city clients tell their stories. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):8. Unique Identifier : AIDSLINE AIDS/95700239; Six clients of the Division of AIDS Services have filed a lawsuit against New York Mayor Rudolph Giuliani, citing an inability to accommodate their disabilities. One of the named plaintiffs, Henrietta D., lost her benefits after her case manager insisted she visit the office even though she was hospitalized for sympto
HIV-positive father wins visitation battle in Maryland. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):9. Unique Identifier : AIDSLINE AIDS/95700240; David K. North, after a four-year court battle, has been awarded visitation rights with his three daughters. North separated from his wife Kathryn in June 1991 after telling her he was diagnosed with HIV. The custody dispute originally centered around not only North s HIV status, but also his homosexuality (he had lef
Accomplice in death of gay man sentenced to work in AIDS hospice. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):9. Unique Identifier : AIDSLINE AIDS/95700241; Eric Larkins pleaded no contest to one felony and one misdemeanor charge after the jury was deadlocked and could not reach a verdict on a homicide charge for the beating death of a Topeka resident who was perceived to be gay. Larkins, 24, was sentenced to work with AIDS patients. The judge said working with AIDS patie
Poll says American voters want no cutbacks in AIDS funding. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Mar 24;10(5):11. Unique Identifier : AIDSLINE AIDS/95700242; A bipartisan poll on voter attitudes about AIDS, commissioned by the Human Rights Campaign Fund, showed strong support for the Federal government s role in caring for people with HIV. The poll found that 77 percent of those surveyed favor maintaining or increasing Federal funding for AIDS care. 55 percent under age 35
Dentist's 'blatant discrimination' leads to landmark court decision. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):1, 10-1. Unique Identifier : AIDSLINE AIDS/95700282; A Federal judge has ruled that a New Orleans dentist violated the law when he refused to clean the teeth of two HIV-positive patients. Dentist Drew B. Morvant s assertion that he was untrained for handling these types of cases was deemed as purposeful ignorance. The ruling was the first time an AIDS complaint arising
HOPWA's death in the House sets stage for negotiations with Senate. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):1-2. Unique Identifier : AIDSLINE AIDS/95700283; The U.S. House of Representatives has called for the elimination of the Housing Opportunities for People with AIDS (HOPWA) program while the Senate has yet to decide HOPWA s fate. Activists are hoping the Senate conferees will persuade their House counterparts to spare HOPWA and that HOPWA s fate will be brought up du
Uninfected patient can't win damages from doctor with AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):3-4. Unique Identifier : AIDSLINE AIDS/95700284; The Minnesota Supreme Court has ruled that damages cannot be awarded to a woman who claimed emotional distress after learning her doctor was HIV-positive. The doctor was allowed to continue practicing medicine as long as he took certain precautions and stopped performing surgery, with which he complied. When presented
Doctor's wife can't win damages arising from publication of studies. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):4. Unique Identifier : AIDSLINE AIDS/95700285; The Minnesota State Supreme Court ruled that a doctor s wife cannot collect damages arising from the publication of studies which revealed her late husband s positive HIV status. The court stated that the spouse is not entitled to recover damages on behalf of her late husband because the personal injury she claimed he
House passes bill encouraging settlement of civil suits. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):5. Unique Identifier : AIDSLINE AIDS/95700286; The U.S. House of Representatives approved the Attorneys Accountability Act, which would require a plaintiff to pay his opponent s legal costs if an eventual jury award at trial is less than a previous settlement offer. The bill s intent is to discourage frivolous lawsuits and encourage pretrial settlement of suits. A
Aerobics trainer, health club settle discrimination lawsuit. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):5-6. Unique Identifier : AIDSLINE AIDS/95700287; A health club settled out-of-court, agreeing to pay an undisclosed sum of money and to train its managers on the legal obligations of people with HIV and other disabilities, following litigation brought by an aerobics instructor at the club. The instructor filed the suit after he was forced to either disclose his HIV
Law firm quietly drops appeal of 1986 discrimination case. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):6. Unique Identifier : AIDSLINE AIDS/95700288; A Chicago-based law firm abandoned its legal fight to overturn a $500,000 damage award to the estate of a former associate who claimed he was fired because he had AIDS. This settlement represents the third time law firms have decided to settle out of court rather than face a showdown. The other two cases involved Phil
Government clarifies rules for family and medical leave. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):7-8. Unique Identifier : AIDSLINE AIDS/95700289; The Labor Department issued its final regulations to clarify the interplay between the Family and Medical Leave Act (FMLA) of 1993 and the Americans with Disabilities Act (ADA) of 1990. The regulations clarify leaves of absences, the employee s rights to return to work after a leave, and confidentiality of medical rec
Two Philadelphia AIDS agencies face their share of problems. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):8. Unique Identifier : AIDSLINE AIDS/95700290; Philadelphia s AIDS Activities Coordinating Office (AACO) and the Philadelphia AIDS Task Force (PATF) have both undergone several recent lawsuits for misdeeds. AACO officials admitted to mistakenly revealing the HIV status and sexual orientation of 36 people who served on a community advisory committee for prevention
Public health clinics do better than doctors in HIV counseling. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):9. Unique Identifier : AIDSLINE AIDS/95700291; A national study conducted by the Centers for Disease Control and Prevention (CDC) suggests that public health clinics are doing a better job than private physicians in educating Americans about preventing the spread of HIV. Random phone calls to 84,039 adults in 49 states and the District of Columbia show that nearly
Jobless benefits denied to teacher who failed to seek alternate work. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):9. Unique Identifier : AIDSLINE AIDS/95700292; The Pennsylvania Commonwealth Court denied a teacher s assistant, who was HIV-positive, unemployment benefits because it held that the teacher had left his employment voluntarily and failed to seek alternative employment with his employers. The plaintiff claimed he felt forced to quit his classroom job because he fear
Doctors who discriminate are paying a steep price. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Policy Law. 1995 Apr 7;10(6):10. Unique Identifier : AIDSLINE AIDS/95700293; Memorial Hospital and Charles Hull, MD, refused to admit an AIDS patient who had had an allergic reaction to a prescription drug. A Federal district court jury awarded the patient $512,000 in compensatory and punitive damages because the hospital had violated the Rehabilitation Act of 1973 which prohibits a Federally-
3TC and AZT. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):2. Unique Identifier : AIDSLINE AIDS/95700317; The combination of AZT and 3TC has proven to be effective in reducing HIV levels in some people in several clinical trials recently reported on at a scientific conference in Scotland.
AZT and children. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):2. Unique Identifier : AIDSLINE AIDS/95700318; The AZT part of a study (ACTG 152), examining three different treatments for children (aged 3 months to 18 years) with sympomatic HIV infection, was stopped because the interim results showed AZT alone was the least effective of the three treatments,
Protease inhibitor studies enrolling. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):3. Unique Identifier : AIDSLINE AIDS/95700319; The protease enzyme is essential for HIV to make copies of itself. So far, research has failed to find a protease inhibitor that works against HIV. It is believed that, regardless of what type of protease inhibitor someone takes, it will need to be supplemented with other anti-HIV drugs. Three
Herpes cancer? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):3. Unique Identifier : AIDSLINE AIDS/95700320; Two researchers have announced there is strong evidence that Kaposi s sarcoma (KS) is actually caused by a newly recognized herpes virus which is called KSHV. Herpesviruses have long been suspected as co-factors in HIV disease, although before now they have not been linked to KS. Another group of scientists suggests t
Aspirin study stopped. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):4. Unique Identifier : AIDSLINE AIDS/95700321; A study using high-dose aspirin treatment for HIV infection was stopped due to side effects, including reduction in red blood cells and a modest increase in liver enzymes. When treatment stopped, lab values returned to normal. Material strongly cautioning people about trying aspirin on their own was released in connec
What's in the water? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):4-5. Unique Identifier : AIDSLINE AIDS/95700322; Cryptosporidiosis is a protozoal infection that can come from water, or be spread from person to person. Individual protozoa are very resistant to the environment and disinfectants. How cryptosporidium causes infection is unknown, but it is known that large adult animals that commonly become infected do not get sick;
Considering alternative treatments. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):7. Unique Identifier : AIDSLINE AIDS/95700324; When considering alternative treatments for HIV infection it is important to first gather as much information on the treatment as possible. It was emphasized at the Fifth Annual Statewide HIV/AIDS Policy Conference that alternative medicine can be used to complement traditional medicine, such as helping the body handl
Boxwood. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):7. Unique Identifier : AIDSLINE AIDS/95700325; An extract of SPV-30, a herbal compound called Boxwood, has exhibited anti-HIV activity in lab tests and a small, placebo controlled trial. Arkopharma, the French company that makes the extract, has agreed to donate Boxwood for ten informal studies in the U.S. Each study will enroll forty to fifty people and last six
Immune restoration--conference outlines future directions. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Mar 3;(no 218):3-4. Unique Identifier : AIDSLINE AIDS/95700352; James JS; The Immune Restoration Think Tank meeting held February 24-26, 1995, discussed current and future research in the area of immune restoration. Immune restoration research is trying to find ways to help the immune system recover after it has been depleted by immunity destroying diseases such as AIDS. The February meetin
Proving clinical benefit in small, rapid trials: statement to National Task Force on AIDS Drug Development. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Mar 3;(no 218):4-6. Unique Identifier : AIDSLINE AIDS/95700353; James JS; John S. James of AIDS Treatment News presents his thoughts to the National Task Force on AIDS Drug Development on the clinical benefits of small, rapid trials. Two main points are made: the first involves resolving the conflict between surrogate markers versus clinical endpoints. Mr. James suggests that the provisiona
Sulfasalazine: arthritis drug increases CD4 count? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Mar 3;(no 218):6-7. Unique Identifier : AIDSLINE AIDS/95700354; Smith D; Sulfasalazine, a drug commonly used to treat arthritis, has been shown to increase CD4 counts in people with HIV, substantially in some patients. Researchers published their findings in April s Journal of Rheumatology (vol. 21, no. 4). Sulfasalazine has been known to suppress certain inflammatory responses of the immu
Viatical settlement tax reform: Republicans support relief, Democrats divided. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Mar 3;(no 218):7-8. Unique Identifier : AIDSLINE AIDS/95700355; James JS; Roehr B; Congress is considering the tax exempt status on money received from a life insurance policy before death of a person with a short life expectancy due to illness. Tax exempt status is being considered for both accelerated benefits and viatical settlement. Accelerated benefits allows for pre-payment in advance of death
Enteric viruses associated with HIV infection in Tanzanian children with chronic diarrhea.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):296-9. Unique Identifier : AIDSLINE AIDS/95330393; Cegielski JP; Msengi AE; Miller SE; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, USA.; OBJECTIVE. To determine whether specific viruses are associated with HIV infection in Tanzanian children with chronic diarrhea. DESIGN. Cross-sectional survey. SETTING. Major national teaching hospital in Dar es Salaam, Tanzania. PATIENTS. Consecutively admitted, human immunodeficiency virus (HIV)-infected and HIV-uni
Measles immunity in HIV-infected children.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):300-4. Unique Identifier : AIDSLINE AIDS/95330394; Walter EB; Katz SL; Bellini WJ; Department of Pediatrics, Duke University Medical Center, Durham,; North Carolina, USA.; In a retrospective study, sera from 84 children of human immunodeficiency virus (HIV)-seropositive mothers (35 HIV-infected and 49 uninfected children) with a known date of receipt of measles, mumps, and rubella vaccine were tested for antibody to measles vaccine by an indirect enzyme immunoassay (EIA) method and/or m
Abdominal lymphadenopathy in children with AIDS.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):305-8. Unique Identifier : AIDSLINE AIDS/95330395; Chung CJ; Sivit CJ; Rakusan TA; Ellaurie M; Department of Diagnostic Imaging and Radiology, Children's; National Medical Center, Washington, DC, USA.; PURPOSE. To identify conditions associated with abdominal lymphadenopathy in children with vertically-transmitted human immunodeficiency virus (HIV) infection. METHODS. Abdominal computed tomography (CT) scans were performed on 29 children over an eight-year period. The presence or absence of abdominal lymphadenopathy
Human immunodeficiency virus transmission in household settings--United States.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):325-8. Unique Identifier : AIDSLINE AIDS/95330458
Antiretroviral therapy for infection due to human immunodeficiency virus in children.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):273-95. Unique Identifier : AIDSLINE AIDS/95330392; Pizzo PA; Wilfert C; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland, USA.
Effect of CD8 T cell lines derived from vertically HIV infected children on HIV replication in naturally infected cells. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330396; Heerema AE; Holmes DR; Sullivan JL; Luzuriaga K; Dept. of Pediatrics, Univ. of Mass. Medical Center, Worcester,; USA.; The CD8 T cell population undergoes rapid early expansion in vertical HIV infection, yet the functional capabilities of those CD8 T cells are not well defined. Our lab has previously described a deficient CD8 T cell mediated HIV-specific CTL response in vertically-infected children. Several groups have reported a spec
In vitro anti-HIV antibody production (IVAP) in HIV-infected children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330397; Wang XP; Abrams E; Bamji M; Bakshi S; Paul M; Tetali S; Pahwa S; North Shore Univ. Hosp.-Cornell Univ. Med. College, Dept.; Pediatrics, Manhasset, NY, USA.; Timing of transmission and markers of disease progression are clinically important topics in HIV vertical transmission. In this study, IVAP (a revised method to exclude false positive results) was analyzed concurrently with virus culture, polymerase chain reaction (PCR) and clinical disease in 30 HIV-infected infants.
Ontogeny of HIV-1 specific CTL in vertical infection. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330398; Holmes DR; Heerema AE; Sullivan JL; Luzuriaga K; Dept. of Pediatrics, Univ. of Massachusetts Medical School,; Worcester, USA.; The capability of the young infant to mount virus-specific CTL responses is not well-described. We have previously described a deficiency of HIV-1 specific CTL in older HIV-1 infected children. HIV-1 specific CTL responses were studied in 11 infants born to HIV-1 seropositive women; 7 of those infants were 4 months or
Specific activation of natural killer (NK) cells. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330399; Reichlin A; Karlhofer FM; Yokoyama WM; Mount Sinai Medical Center, Department of Pediatrics, New York,; NY, USA.; NK cells are the third largest population of lymphocytes and provide significant host responses to intracellular challenges, including viruses, Listeria, and Toxoplasma, by lysing infected cells and by producing cytokines. However, the molecular basis of recognition and activation is still not fully understood. Monocl
The need for physician education regarding pediatric immunization practices. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330400; Matson CC; Butterfoss FD; Rosenthal J; Morrow AL; Center for Pediatric Research, Eastern Virginia Medical School,; Children's Hospital of the King's Daughters, Norfolk, USA.; AIM: Physician practices are critical determinants of immunization rates of children under 2 yrs of age. The aims of this study were to examine physician perception of barriers to childhood immunizations and compliance with immunization practice standards. METHODS: From 6/93 to 8/93, all pediatricians and family physi
The HIV membrane gp 120 protein is toxic to human brain cell cultures through the induction of interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha). American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):314 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330401; Yeung M; Pulliam L; Lau A; Dept Pediatrics, San Francisco Gen Hosp, CA, USA.; The AIDS dementia complex is a common and an important cause of morbidity in children with HIV infection. It is characterized by developmental delay, mental changes, and motor defects. We hypothesize that in AIDS dementia, HIV-1 gp 120 induces neurotoxicity through an uncontrolled
Evolution of natural killer (NK) function in HIV+ children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330402; Schuval SJ; Hatam L; Bonagura VR; Dept. Peds. Schneider Children's Hospital, Long Island Jewish; Medical Center, New Hyde Park, NY 10042, USA.; We previously identified NK deficiency in HIV+ infants (mean
Exposure to zidovudine in the fetal baboon. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330403; Garland M; Stark RI; Szeto HH; Myers MM; Dept of Peds, College P & S Columbia Univ., NY, NY, USA.; Zidovudine (ZDV) is currently administered to HIV-infected women during pregnancy. The drug is also being studied as an agent for prevention of vertical transmission of HIV and for treatment of infected fetuses. Better understanding of the pharmacokinetics of ZDV in the maternal-fetal unit will improve prediction of ep
Induction of cytokine expression in trophoblastoid JAR cells by immune complexes: implications for vertical transmission of HIV. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330404; Jarvis JN; Moore HT; Iobidze M; Dept. of Pediatrics, Wayne St. U., Detroit, MI, USA.; Mechanisms through which HIV is transferred from mother to fetus remain unknown. It has been speculated that infectious HIV immune complexes (IC s) may be the vector for viral to entry into fetal tissue. We propose another mechanism which may explain how IC s facilitate the spread of HIV from mother to fetus: the indup
Induction of hematopoietic cytokines by HIV gp160 in cord blood. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330405; Than S; Oyaizu N; Pahwa S; North Shore University Hospital-Cornell University Medical; College, Department of Pediatrics, Manhasset, NY, USA.; Aberrant immune activation and cytokine dysregulation occurs in HIV infection. Previously we have reported that HIV envelope protein gp160 can enhance myelopoiesis in cord blood (Blood, 80: 1463, 1992). This study investigates influence of HIV gp160 in secretion of humoral CSFs: IL-3, IL-6 and GM-CSF which are essentip
Nitric oxide production by alveolar macrophages from newborn versus infant and adult rats. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330406; Sherman MP; Wong VZ; Univ. of Kansas, Kansas City, USA.; Human immunodeficiency virus (HIV) infection of newborns progresses to AIDS more rapidly than infection in later life. Since nitric oxide (NO) blocks lymphocyte proliferation and HIV gp120 stimulates NO production by human macrophages (M phi), we postulate that excessive NO production by newborn M phi causes rapid HIVp
Prediction of pediatric neuro-AIDS. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):315 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330407; Wachtel RC; Tepper VJ; Farley J; Houck D; Vink P; University of Maryland School of Medicine, Department of; Pediatrics, Baltimore, USA.; As part of a longitudinal study of 35 vertically HIV-infected infants, laboratory data at 6 months of age were compared to Bayley Scales of Infant Development scores (MDI & PDI) at 12 and 24 months of age using bivariate linear regression. Highly significant predictive relationships were found between absolute lymp
Adolescents' knowledge and use of confidential health services and their acquisition and use of condoms. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330408; Klein J; Siegel D; Rossbach C; Flatau C; Division of Adolescent Medicine, University of Rochester School; of Medicine, NY, USA.; OBJECTIVE: Condom use is a critical part of HIV and STD prevention for sexually active youth. We studied how and where adolescents obtain condoms and the relationship between condom acquisition and adolescents knowledge of and use of confidential health services. DESIGN: We screened 7400 numbers and identified 2469 h
Condom availability and accessibility in Rochester, NY. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330409; Klein I; Rossbach C; Siegel D; Nijher H; Geist M; Cohn SE; Weitzman M; Division of Adolescent Medicine, General Pediatrics and; Infectious Disease, Univ. of Rochester School of Medicine, NY,; USA.; OBJECTIVE: Condom use is affected by knowledge, attitude, and perceived risks and benefits. Access to condoms also may influence condom related behaviors, thus we studied the availability and accessibility of condoms and other HIV prevention material in retail stores in areas with high and low sexually transmitted dis
Congenital syphilis in infants of adolescent mothers. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330410; Risser WL; Hwang LY; Dept. of Peds., Univ. of Texas Health Sciences Center, Houston,; USA.; OBJECTIVE: To characterize adolescent mothers who had syphilis during pregnancy; determine the incidence of congenital syphilis (CS) in their infants; and assess risk factors for their failure to receive successful treatment during pregnancy. DESIGN: Retrospective cohort study using data of the Houston Health and Huma
Coordination, comprehensiveness and access to reproductive health services in school-based clinics. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330411; Klein JD; Zukoski AP; Division of Adolescent Medicine, University of Rochester, NY,; USA.; OBJECTIVE: Access to comprehensive, coordinated health services is believed to improve adolescents health. However, many school-based health clinics have difficulty providing a full range of reproductive health services. We studied school-based health clinics coordination with other provider organizations in relatio
HIV/AIDS knowledge, attitudes, and comfort in adolescent peer listeners. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330412; Marlowe AL; Boehm KE; Schondel CK; Hitts JS; Medical College of Ohio, Department of Pediatrics, Toledo, USA.; Despite increased educational efforts, there was a 300% increase in AIDS cases in the 13-19 year old age group in the most recent CDC report. In the last 3 1/2 years there were only 27 calls out of 6,993 to a teen peer phone listening service about HIV/AIDS. We report on teen volunteers HIV/AIDS knowledge and attitud
Physician attitudes towards delivering STD/HIV-related preventive services to teens. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):316 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330413; Igra V; Millstein SG; Dept. of Peds., University of California, San Francisco, USA.; Little is known about physicians delivery of preventive services to adolescents. Given the significant morbidity associated with teen sexual behavior, STD/HIV-related preventive services are critical for this population. Yet research on physician attitudes towards providing these often controversial services is unava
Age at sexual debut predicts sexually transmitted disease knowledge among adolescent males. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330414; Genuardi FJ; Boker JR; Oh MK; Department of Pediatrics, University of Alabama at Birmingham,; USA.; OBJECTIVE. To determine whether sexually transmitted disease (STD) knowledge is better in adolescent males with a later age at sexual debut, and whether this knowledge correlates with either subsequent sexual behavior or STD history. METHODS. A group of adolescent male high school student athletes was surveyed during
Communication between adolescents and doctors about sexual behavior and risk prevention. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330415; Schuster MA; Bell R; Petersen L; Kanouse D; RAND, Santa Monica, CA, USA.; The American Academy of Pediatrics recommends that physicians take a sexual history, discuss risk prevention, and assure confidentiality with all patients in early adolescence. Little is known, however, about the extent to which such discussions take place. We conducted an anonymous self-administered survey of 2026 9t
Perseverance pays off: health care providers' impact on HIV testing decisions by female adolescents. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330416; Goodman E; Tipton AC; Hecht L; Chesney MA; Harvard University, Boston, MA, USA.; HIV testing services for teenagers have expanded in recent years following the recognition that adolescents are at significant risk for acquiring HIV. However, little is known about what leads adolescents who engage in high risk behaviors to be tested for HIV or what distinguishes those who obtain testing from those w
Physicians' attitudes towards a notification program of transfusion-related HIV risk in pediatric cardiac surgical patients. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330417; McCrindle BW; King SM; Newman A; Murphy T; Corey M; Poon AO; Freedom RM; Dept. of Peds., Hospital for Sick Children, Toronto, Canada.; STUDY AIM: To determine demographic, practice and attitudinal factors that predict physicians acceptance of a patient notification program of transfusion-related HIV exposure. SUBJECTS AND METHODS: All responsible physicians for 1793 children who underwent open heart surgery between 1979 and November, 1985 at the Hos
Prevention of HIV infection in adolescents. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330418; Siegel DM; Aten MJ; Roghmann K; Dept of Peds., Univ. of Rochester School of Medicine, NY, USA.; Traditional knowledge based interventions designed to change high risk sexual attitudes and behavior in adolescents have not been consistently effective. We have implemented a 12 session, highly interactive, AIDS and sexuality curriculum in 3 middle and 3 senior high (urban) schools designed to affect not only knowled
What do families know about blood product exposure during pediatric cardiac surgery and the risk of HIV infection? American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):317 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330419; McCrindle BW; King SM; Newman A; Murphy T; Corey M; Poon AO; Freedom RM; Dept. of Peds., Hospital for Sick Children, Toronto, Canada.; STUDY AIM: To determine parental and patient knowledge regarding blood product exposure and HIV infection risk, and acceptance of a risk notification program. SUBJECTS AND METHODS: Telephone interviews were obtained from either parents or patients (if over age 16 years) who had been contacted by their responsible phys
Basic fibroblast growth factor and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330420; Ray PE; Bruggeman LA; Weeks BE; Kopp JB; Bryant JL; Owens JW; Notkins AL; Klotman PE; LDB, NIDR, NIH, Bethesda, MD, USA.; We have established a model of HIV-associated nephropathy (HIVAN) in transgenic mice, using a non-infectious HIV-1 construct bearing the viral LTR, the env gene, and regulatory genes (PNAS 89:1577, 1992). Heterozygous mice develop progressive glomerulosclerosis and microcystic tubular dilatation in association with in
Characterization of proteinuria in HIV-infected infants. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330421; Abitol C; Strauss J; Zilleruelo G; Montane B; Roias E; University of Miami/Jackson Memorial Medical Center, Department; of Pediatrics, Florida, USA.; At the University of Miami/Jackson Memorial Medical Center between January 1986 through June 1993, 236 pediatric patients infected with the Human Immunodeficiency Virus (HIV) were followed prospectively for the development of HIV-nephropathy (HIVN). One hundred thirty-seven patients provided urines for the assessment
HIV nephropathy (HIVN) in children: early identification essential. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330422; Strauss J; Zilleruelo G; Abitbol C; Montane B; Scott G; Roias E; Canal-Cano T; Department of Pediatrics, University of Miami, FL, USA.; As we reported (N. Eng. J. Med. 1989; 321:625-630), HIV+ infants and children develop HIVN as often as adults, have a broader spectrum of histologic changes, and longer periods of time between onset of proteinuria and chronic renal failure. The purpose of this study was to further ascertain the natural history, clinic
Quantitation of proteinuria in children with HIV-nephropathy. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):318 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330423; Abitbol C; Strauss J; Zilleruelo G; Montane B; Roias E; University of Miami/Jackson Memorial Medical Center, Department; of Pediatrics, Florida, USA.; Accurate assessment of proteinuria in pediatric patients infected with the Human Immunodeficiency Virus (HIV) is limited by the constraints imposed by timed urine collections in very ill patients. We sought to validate the use of random urine specimens to quantitate total protein and creatinine excretion in a populati
Early determination of HIV infection status among infants born to HIV seropositive mothers. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330424; Paul M; Tetali S; Wang X; Bakshi S; Lesser M; Abrams E; Bamji M; Pahwa S; Dept of Peds, NSUH-CUMC, Manhasset, NY, USA.; Early serologic diagnosis of HIV infection among infants born to HIV positive mothers is problematic because of transfer of maternal antibodies. Based on assay results of peripheral blood from 183 such infants, we formulated 4 sets of diagnostic decision rules incorporating individual assays as well as various assay c
Effects of human immunodeficiency virus (HIV) exposure and infection on plasma glutathione status in children. American Pediatric Society 104th annual and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330425; Smith CV; Rogers LK; Rabin RL; Maldonado YA; Herzenberg LA; Herzenberg LA; Petru A; Department of Pediatrics, Baylor College of Medicine, Houston,; TX, USA.; HIV-infected adults have lower glutathione (GSH) concentrations in plasma than do healthy controls, suggesting that HIV infection may compromise antioxidant defenses and other physiological functions. To determine whether HIV infection similarly affects children, we measured plasma concentrations of GSH, cysteine (CYS
Immunologic changes in the first 6 months of life in subjects born to HIV+ women. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330426; Kovacs A; Pan L; Chan L; Dept of Peds., LAC+USC Medical Center/USC School of Medicine,; USA.; OBJECTIVE: To determine age related changes of immunologic parameters in the first 6 months of life in HIV infected (HIV+) and uninfected (HIV-) children born to infected women. METHOD: Immunologic parameters including CD3, CD4, CD8, B and non-T non-B (NK) lymphocytes were prospectively evaluated in 139 children (36 H
Lymphocyte proliferation and HIV infection: in vitro examination of potential therapeutic strategies. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330427; Krogstad P; Chen IS; Zack JA; Activation and proliferation of CD4 T-lymphocytes is required for productive infection of HIV. When quiescent T-lymphocytes are infected in vitro by HIV-1, the retroviral life-cycle is incomplete, due to failure to complete the reverse transcription process. Quiescent cells infected in this fashion harbor a labile rep
Significance of the immune complex dissociated (ICD) p24 antigen in pediatric HIV infection. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330428; Ascher DP; Waecker NJ; Ottolini MA; Raszka WV; Moriarty R; Robb ML; Dept of Peds, Wilford Hall Medical Center, San Antonio, TX, USA.; The ICD p24 antigen has been demonstrated to increase the sensitivity of p24 antigen testing in adults and children. The ICD p24 antigen has been associated with increasing Walter Reed Stages in adults. We sought to determine if there was an increased positivity of the ICD p24 antigen associated with CDC pediatric sta
The macrophage mannose receptor can mediate the uptake of Mycobacterium avium-intracellulare. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):319 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330429; Kruskal BA; Super M; Rogers R; Ezekowitz RA; Harvard Medical School, Children's Hospital, Div. of Infectious; Diseases, Boston, MA, USA.; In patients with HIV and disseminated M. avium-intracellulare (MAI) infection, large numbers of MAI reside within macrophage phagosomes and survive there, resisting intrinsic macrophage antimycobacterial mechanisms. How MAI enter macrophages and survive has not been well elucidated thus far. Several macrophage cell-su
An association between HIV infection, Epstein-Barr virus (EBV) immune status, cardiomyopathy, and lymphocytic interstitial pneumonia (LIP). American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330430; Valentine M; Tripp M; McKinney RE Jr; Duke University Medical School, Dept. of Pediatrics, Infectious; Diseases and Cardiology, Durham, NC, USA.; Reports have identified an association between co-infection with HIV and EBV, and two HIV associated clinical syndromes, cardiomyopathy and LIP. Using serologic methods we evaluated the EBV status of our current HIV-infected patients between 48 weeks and 12 years old (n = 77). Patients were excluded if they had receiv
Comparative evaluation of virus load in HIV-1 infected children showing slow and rapid disease progression by QC PCR. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330431; Tetali S; Goonewardena H; Bakshi S; Miranda L; Pahwa S; Dept of Peds., North Shore University Hospital-Cornell University; Medical College, Manhasset, NY, USA.; This study is investigating virus load as evaluated by quantitative competitive PCR (QC PCR) in the peripheral blood mononuclear cells (PBMC) of children with HIV-1 infection. Initially we have examined 13 children. Of these 6 were > 5 yrs (5-9 yrs), in CDC class P1, P2A or P2F and were designated as slow progressors
CD8-mediated suppression of autologous HIV-1 replication in a 5 week old HIV-1 infected infant. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330432; Pollack H; Zhan MX; Papaevangelou V; Chen SH; Tao P; Krasinski K; Borkowsky W; Dept. of Peds., New York University Medical Center, NY 10016,; USA.; Classical cytotoxic T cell (CTL) assays have failed to demonstrate cell-mediated killing of HIV-1 in infants less than 6 months of age. Using an in vitro EBV-stimulated lymphocyte culture technique we have been able to detect evidence of CD8-mediated control of HIV-1 viral replication in a 5-week old HIV-1 infected in
Delayed type hypersensitivity (DTH) skin testing in HIV infected (HIV+) children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330433; Raszka WV; Moriarty RA; Waecker NJ; Ascher DP; Ottolini MG; Cieslak TS; Birx D; Robb ML; Department of Pediatrics WBAMC, El Paso, TX, USA.; BACKGROUND: Although DTH skin testing to recall antigens has been used to clinically stage adults with HIV disease, little is known about the ability of HIV+ children to mount an immune response to intradermally placed antigen. METHODS: The DTH responses of HIV+ children who survived the first year of life were prospe
Response to trivalent influenza vaccine in children vertically infected with HIV. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330434; Tressler RL; King JC; Batlas S; Stancliff C; Farley JI; Vink PE; Univ. of Md. Hosp., Dept. of Pediatrics, Balto., USA.; The CDC recommends that all individuals > 6 months of age receive trivalent inactivated influenza (Flu) vaccine if they or a household member is HIV infected. However, there is limited data on the immunologic response to Flu vaccine in HIV-infected children. We report data on the serologic response of children exposed
Virologic markers of human immunodeficiency virus (HIV) in cerebrospinal fluid (CSF) of infected children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):320 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330435; Pratt RD; Nichols S; Dankner WM; Spector SA; University of California, San Diego, USA.; Central nervous system (CNS) abnormalities and neurocognitive deficits often accompany HIV infection in children. In this study, we examined CSF of HIV-infected children for the presence of virologic markers. 33 CSF specimens were obtained from 26 children; 21 from children perinatally infected and 5 infected via bloo
Antibody response to booster doses of hepatitis B vaccine in HIV-infected children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330436; Choudhury SA; Hodes DS; Peters VB; Department of Pediatrics, Mount Sinai School of Medicine, N.Y.,; N.Y., USA.; We previously showed that the antibody response to Hepatitis B vaccine is poor in HIV-infected children (Pediatr Infect Dis J 1993; 12:877-8). In order to assess the utility of a booster dose, we administered Engerix at double the AAR-recommended dose to 14 symptomatic HIV-infected children (mean age 58 months, mean C
Disseminated Mycobacterium bovis (BCG) in a child with HIV infection. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330437; Ellaurie M; Rakusan T; Gutierrez MP; Sever J; Children's National Medical Center, Washington, DC, USA.; RD is a 27 month old child from Brazil with perinatal HIV infection who presented at 14 months of age with a history of recurrent fever and oral thrush , episodic diarrhea, anemia and developmental delay. Physical exam revealed oral candidias
HIV infection and neonatal & maternal characteristics. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330438; Fuchs G; Tienboon P; Sirivatanapa P; Sirisanthana V; Ruangyuttikarn C; Suskind R; RIHES, Chiang Mai University, Thailand.; Thirty HIV seropositive mother-infant pairs were retrospectively studied. Maternal gestational weight gain, infant birthweight, and ultimate confirmed HIV infection status of the infants were reviewed. Mean gestational age of all infants was 39 weeks +/- 2.3, and mean birthweight 2923 g +/- 433. Seventeen percent of i
HIV-specific IgA in infants born to HIV seropositive women. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330439; Livingston RA; Hutton N; Halsey NA; Kline RL; Joyner M; Butz A; Quinn TC; Department of Pediatrics, Johns Hopkins Univeristy, Baltimore,; USA.; OBJECTIVES: To determine the sensitivity and specificity of HIV-specific IgA in the diagnosis of vertically-transmitted HIV infection including the first month of life. DESIGN/PATIENTS: Prospective cohort study of 117 infants born to HIV-seropositive women in a teaching hospital serving a large urban center, and 192 o
Quantitative immunofluorescent measurements of surface receptors on immune subsets from HIV infected children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330440; Denny TN; Stein D; Ince L; Mui T; Dieudonne A; Oleske JM; Department of Pediatrics, New Jersey Medical School, Newark, USA.; It is possible to determine the antibody binding Capacity (ABC) per cell by performing quantitative immunofluorescent flow cytometric analysis of immune subsets. This study evaluated the number of ABC for CD3, CD4, CD8, CD16, and CD19 on lymphocytes and for CD4 and HLA-DR on monocytes. Peripheral blood samples were av
Routine immunizations of HIV-infected individuals and HIV replication. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):321 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330441; Ramilo O; Bell KD; Jue LS; Squires JE; Vitetta ES; UT Southwestern Medical Center, Dallas, USA.; Two different populations of HIV-infected T cells are present in the peripheral blood of HIV-infected individuals: activated cells that produce virus and spread the infection, and quiescent cells that do not produce virus but harbor the viral genome. In vitro experiments have demonstrated that these quiescent cells ar
A clinical staging system to predict survival of infants with perinatally acquired HIV infection. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330442; Forsyth BW; O'Conner T; Andiman WA; Yale University, Department of Pediatrics, New Haven, CT, USA.; Information concerning prognosis and survival of HIV-infected infants should be helpful in clinical decision making and stratification for clinical trials. The purpose of this study was to develop a clinical staging system to be used in infancy to predict survival of HIV-infected children. We reviewed the clinical cou
Analysis of early viral load in infants with perinatally-acquired HIV. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330443; Palumbo PE; Kwok S; Waters S; Wesley Y; McKinney N; Oleske JM; Connor EM; Dept. of Pediatrics, UMD-New Jersey Medical School, Newark, USA.; The dynamics of HIV infection early in perinatally infected infants is poorly understood. Serial plasma and mononuclear cell (MNC) samples from 8 HIV-infected infants were assayed by quantitative RNA PCR for free virus and by quantitative DNA PCR for infected cells. Virus was detectable by RNA PCR in 6/8 infants in th
Clinical characteristics of children enrolled into a randomized, double-blind trial of antiretroviral therapy (ACTG 152). American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330444; Englund JA; Baker CJ; McKinney RE Jr; Raskino CL; Schoenfeld DA; Petrie BL; Lifschitz MC; O'Donnel K; Wara DW; Fowler MG; Baylor College of Medicine, Houston, TX, USA.; The first comparative antiretroviral trial in symptomatic, HIV-infected children evaluates the efficacy of zidovudine (ZDV) vs didanosine (DDI) vs ZDV plus DDI. From 8/91 to 8/93, 839 infants and children were enrolled from 77 sites in 20 states and Puerto Rico . All received ei
HIV-1 in cervico-vaginal secretions of infected mothers and in the gastric aspirates of their infants. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330445; Nielsen K; Boyer P; Dillon M; Dickover R; Wafer D; Wei L; Bryson Y; Dept. of Pediatrics, UCLA School of Medicine, USA.; In pregnant HIV-1 infected women, the presence of HIV in genital secretions during labor and delivery may be important for vertical transmission. We conducted a pilot study investigating the presence of HIV-1 in the cervico-vaginal secretions of 16 women (13 pregnant/4 post delivery) and in the gastric aspirates of 11
Laboratory characteristics of children enrolled into a randomized, double-blind trial of antiretroviral therapy (ACTG 152). American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330446; Englund JA; Baker CJ; McKinney RE Jr; Raskino CL; Schoenfeld DA; Wara DW; Baylor College of Medicine, Houston, TX, USA.; ACTG 152 is a randomized, double-blind trial comparing the efficacy of zidovudine (ZDV) vs didanosine (DDI) vs ZDV plus DDI in symptomatic, HIV-infected children age 3 mo to 18 yrs. From 8/91 to 8/93, 839 patients who had received either no or
Sinusitis in HIV-infected children. The NICHD IVIG Clinical Trial Study Group. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):322 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330447; Mofenson L; Pelton S; Moye J Jr; Nugent R; Korelitz J; Bethel J; PAMA, NICHD, NIH, Bethesda, MD, USA.; In a cohort of 376 HIV-infected children enrolled in a clinical trial of IVIG prophylaxis, 95 episodes of sinusitis were reported in 60 pts during 543 pt-yrs of follow-up (49 in 30 IVIG pts vs 46 in 30 PL pts). Sinusitis was the fourth most common infection (17 per 100 pt-yrs), exceeded only by otitis, pneumonia,
Antibody response to 23-valent pneumococcal vaccine in HIV-infected children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330448; Peters VB; Hodes DS; Diamant EP; Cimino CO; Madore DV; Dept of Pediatrics, Mount Sinai School Medicine, N.Y.; Lederle-Praxis Biologics, USA.; We evaluated the Ab response to 5 pneumococcal polysaccharides in HIV-infected children immunized with pneumococcal vaccine. 13 children (Group I) had Ab levels before and 3-5 mos after immunization (at vaccine, mean age 60 mos, mean CD4 cell count 465/mm3, 77% on antiretroviral Rx). In addition, we did a cross-sectio
In vitro and in vivo correlates of ZDV/DDI/nevirapine therapy of HIV-1 infection. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330449; Sullivan JL; Brewster F; Somasundaran M; Greenough T; Pauletti D; Shih CK; Griffin J; Myers M; Luzuriaga K; Dept. of Pediatrics, Univ. of Mass. Med. School, Worcester, USA.; Replication of laboratory and primary isolates in the presence of ZDV/DDI/Nevirapine (NVP) therapy has been examined in vitro and in vivo. Laboratory (IIIB) and primary isolates resistant to ZDV/NVP were cultured in vitro with ZDV(1 microM), NVP (1 microM) and increasing (2, 10, 20 microM) concentrations of DDI. DDI d
Markers prognostic for survival in zidovudine treated, HIV infected children. ACTG Protocol 043 Study Group. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330450; McKinney RS; Duke University Medical Center, Durham, NC, USA.; ACTG Protocol 043 was a Phase II study of Zidovudine (ZDV) in symptomatic HIV infected children. 88 children participated in the study. Children received ZDV 180 mg/m2/dose q6h. Enrollment was between 4/88 and 1/89, and the children remained on study until 5/90. Survival follow-up was available on all patients as of 4
Oral infection of neonatal rhesus monkeys with cell-free simian immunodeficiency virus. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330451; Baba TW; Koch JA; Greene MF; Wyand MS; Penninck D; Ruprecht RM; Joint Program in Neonatology, Dana-Farber Cancer Institute,; Brigham and Women's Hospital, Harvard Medical School, Boston, MA,; USA.; Approximately half of the infants congenitally infected with the human immunodeficiency virus type 1 (HIV-1) seem to become infected late in gestation or during delivery. The mechanism for HIV-1 transmission during parturition is unknown; however, an association between the presence of serosanguineous fluid in neonata
Results of a clinical trial comparing two doses of 2'3'-dideoxycytidine (ddC) in the treatment of children with symptomatic human immunodeficiency virus (HIV) infection who were intolerant or had failed zidovudine (ZDV) therapy (ACTG 138). The Pediatric AIDS Clinical Trials Group. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330452; Spector SA; Blanchard S; Connor EM; Salgo MP; McNamara J; Univ. of Calif., San Diego, USA.; ACTG 138 compared the long-term safety, tolerance and potential efficacy of high dose ddC .01 mg/kg q8h (HD group) vs low dose ddC .005 mg/kg q8h (LD group) given p.o. to 170 HIV-infected children (HD group: n = 86, LD group: n = 84) who had failed ZD
Tuberculosis (TBC) in HIV-exposed or infected U.S. children. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):323 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330453; Gutman L; Moye J; Zimmer B; Tian C; Dept. of Peds., Duke University, Durham, NC, USA.; We conducted a retrospective questionnaire survey of the 72 pediatric HIV referral children in the U.S. that compose the Pediatric AIDS Clinical Trials Group (PACTG) to determine the extent and rate of occurrence of TBC in children age
Antitubulin drugs inhibit HIV-1 replication by blocking tyrosine phosphorylases. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):324 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330454; Nquyen QV; King RL; Department of Pediatrics, SUNY Health Science Center, Syracuse,; USA.; We have demonstrated that nocodazole, a reversible blocker of microtubule polymerization, inhibited human immunodeficiency virus entry and proliferation in human CD4 + T lymphocytes. This inhibitory effect did not seem to be due to a direct effect on the HIV-1 virion, but seemed to be related to the action of nocodazo
Cord blood hCG levels in infants born to HIV positive women: correlation with transmission. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5, Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):324 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330455; Nachman SA; Chasalow FI; Blethen SL; Weiser B; Tropper P; Navaie M; Burger H; Dept. of Peds., SUNY Stony Brook, USA.; We measured human chorionic gonadotropin (hCG) in cord serum from 15 infants born to HIV infected women. HCG was also determined in cord serum from 173 infants born at a suburban hospital with a low incidence of HIV infection. In this group, 16 of 173 (10%) samples had hCG greater than 90 IU/L (values were distributed
Human immunodeficiency virus associated non-Hodgkin's lymphoma (HIV-NHL). American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):324 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330456; Miller ST; Rao SP; Desai N; Fikrig S; Handelsman E; Anderson V; Haller JO; SUNY-Children's Medical Center of Brooklyn, USA.; While HIV-NHL is commonly seen in adults, it is only occasionally reported in children; optimal therapy remains unclear. We have treated three children with perinatally acquired HIV infection for disseminated NHL using COMP (cyclophosphamide, vincristine, methotrexate, prednisone). Ages were 27, 30, and 39 months at d
Regulation of the DNA repair enzyme beta-polymerase by HIV. American Pediatric Society 104th annual meeting and Society for Pediatric Research 63rd annual meeting; 1994 May 2-5; Seattle.: Pediatr AIDS HIV Infect. 1994 Oct;5(5):324 (unnumbered abstract). Unique Identifier : AIDSLINE AIDS/95330457; Tendler C; Milani D; Srivastava D; English M; Licht J; Wilson S; Division of Pediatric Hematology/Oncology, Mount Sinai School of; Medicine, New York, NY, USA.; The mechanism by which HIV infection results in the malignant transformation of B-cells is unknown. Dysregulation of host DNA repair by HIV may contribute to AIDS lymphoma. Therefore, we wished to determine the effect of the HIV regulatory proteins, tat and rev, on the expression of the essential DNA repair enzyme bet
Prevention and treatment studies for CMV open. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):5. Unique Identifier : AIDSLINE AIDS/95700323; A herpesvirus called cytomegalovirus ( CMV ) is treatable with either ganciclovir or foscarnet. Both have previously been delivered intravenously, however, an oral form of ganciclovir has been produced for use in the maintenanc
Treatment review. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Rev. 1995 Mar/Apr;(no 17):8. Unique Identifier : AIDSLINE AIDS/95700326; A number of studies are being conducted for HIV infections and opportunistic infections; these studies involve both new drugs and drugs currently in use, although administered differently or used for less traditional diseases. The studies include use of 1) foscarnet for treatment of early Kaposi s sarcoma; 2) tecogale
Infection control guidelines from Ohio State Dental Board.: Cincinnati Dent Soc Bull. 1986 Sep;55(7):21, 23-4. Unique Identifier : AIDSLINE MED/95316991; Tomasi NJ
Virostatic in vivo effect of elliptinium on Friend's retrovirus (a model for HIV infection).: Biomed Pharmacother. 1990;44(1):1-3. Unique Identifier : AIDSLINE MED/95329597; Mathe G; Chenu E; Bourut C; Institut du Cancer et d'Immunogenetique, Hopital Paul-Brousse,; Villejuif, France.; As we had discovered the virostatic effects of some analogues of acriflavine, a non-oncostatic intercalating agent, on HIV1 and on its best murine model, Friend s virus [7], we then studied other non- or poorly oncostatic intercalating agents, in particular ellipticins (whose negligible cytostatic effect with methoxy-
In vitro immunomodulatory effects of traditional Kampo medicine (sho-saiko-to: SST) on peripheral mononuclear cells in patients with AIDS.: Biomed Pharmacother. 1990;44(1):17-9. Unique Identifier : AIDSLINE MED/95329599; Inada Y; Watanabe K; Kamiyama M; Kanemitsu T; Clark WS; Lange M; Department of Medicine, St Luke's-Roosevelt Hospital Center,; College of Physicians and Surgeons of Columbia University, New; York 10025, USA.
Biologic activities of HIV-1 envelope glycoprotein: the effects of crosslinking.: Biomed Pharmacother. 1990;44(1):5-11. Unique Identifier : AIDSLINE MED/95329605; Cruikshank WW; Center DM; Pyle SW; Kornfeld H; Pulmonary Center, Boston University School of Medicine, Conte; Center, MA 02118-2394, USA.; We have examined the biologic activities of native and recombinant preparations of human immunodeficiency virus envelope glycoprotein (gp120), both derived from the HIV-1B strain. Antibody to gp120 was used to evaluate the effects of crosslinking gp120 on signalling by the CD4 receptor. Our results indicate that nativ
Can virostatic chemotherapy and/or adoptive allogeneic immunotherapy eradicate in vivo Friend's virus infection? [letter]: Biomed Pharmacother. 1990;44(1):57-9. Unique Identifier : AIDSLINE MED/95329607; Mathe G; Trabaud M; Chenu E; Bourut C; While none of the three drugs which exert an in vitro anti-HIV effect, neither AZT nor the other two, acriflavine and elliptinium, which we have shown to be more efficient than AZT, is able to eradicate Friend s virus in vivo, the combination of the 3
Differential inhibition of the activities of reverse transcriptase and various cellular DNA polymerases by a traditional Kampo drug, sho-saiko-to.: Biomed Pharmacother. 1990;44(1):13-6. Unique Identifier : AIDSLINE MED/95329598; Ono K; Nakane H; Fukushima M; Chermann JC; Barre-Sinoussi F; Laboratory of Viral Oncology, Aichi Cancer Center Research; Institute, Nagoya, Japan.; A traditional Kampo drug, Sho-saiko-to, composed of several herb extracts, differentially inhibited the activities of reverse transcriptase and human cellular DNA polymerase alpha and beta. Reverse transcriptases from murine leukemia virus and human immunodeficiency virus were inhibited by over 80% and 50%, respective
News about AIDS [news]: World Health Forum. 1995;16(2):216-8. Unique Identifier : AIDSLINE MED/95314716
Need for action against tuberculosis [news]: World Health Forum. 1995;16(2):218-9. Unique Identifier : AIDSLINE MED/95314717
A comparison of susceptibility to five antifungal agents of yeast cultures from burn patients.: Burns. 1995 May;21(3):167-70. Unique Identifier : AIDSLINE MED/95314742; Still JM Jr; Law EJ; Belcher KE; Spencer SA; Augusta Regional Medical Center, Georgia, USA.; Patients with significant degrees of immunocompromise, such as cancer, AIDS and large burns, who have received significant amounts of antibiotics, may develop infections with yeast organisms. Over a 3-year period, all patients with positive fungal blood cultures and most wounds of patients with large burns considered
Transgenic models of HIV-1 [editorial]: AIDS. 1995 Apr;9(4):313-24. Unique Identifier : AIDSLINE MED/95314785; Klotman PE; Rappaport J; Ray P; Kopp JB; Franks R; Bruggeman LA; Notkins AL; Transgenic technology has been very successful at providing insights into possible processes involved in HIV-induced pathogenesis. The availability of these small animal models for the study of HIV-related syndromes including KS, epidermal proliferative lesions, HIV-associated nephropathy, AIDS-related growth failure
Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. Military Medical Consortium for Applied Retroviral Research.: AIDS. 1995 Apr;9(4):325-8. Unique Identifier : AIDSLINE MED/95314786; Brown AE; Lane JR; Wagner KF; Zhou S; Chung R; Ray KL; Blatt SP; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Washington, DC, USA.; OBJECTIVE: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. DESIGN: Volunteers in the US military s HIV natural history study were 46% white, 44% black, 7% Hispanic and 3% other. Focusing on the comparable groups of whites and blacks, a retrospective analys
Unidirectional budding of HIV-1 at the site of cell-to-cell contact is associated with co-polarization of intercellular adhesion molecules and HIV-1 viral matrix protein.: AIDS. 1995 Apr;9(4):329-35. Unique Identifier : AIDSLINE MED/95314787; Fais S; Capobianchi MR; Abbate I; Castilletti C; Gentile M; Fei PC; Ameglio F; Dianzani F; Institute of Virology, La Sapienza University, Rome, Italy.; OBJECTIVES: To explore the possibility that HIV-1 budding and cellular adhesion molecules co-polarize at cell-to-cell contact sites. To investigate the incorporation of host-cell-derived adhesion molecules into HIV-1. METHODS: The cellular sites involved in HIV-1 budding were examined by transmission electron microsco
High resolution analysis of HIV-1 quasispecies in the brain.: AIDS. 1995 Apr;9(4):345-9. Unique Identifier : AIDSLINE +; Monken CE; Wu B; Srinivasan A; Thomas Jefferson University, Department of Microbiology and; Immunology, Philadelphia, Pennsylvania, USA.; OBJECTIVE: To characterize HIV-1 quasispecies at high resolution to determine the in vivo sequence heterogeneity of virus infecting the brain. METHODS: A 1 kilobase region of the envelope gene, which includes the five hypervariable regions, was amplified by polymerase chain reaction (PCR) using DNA obtained from brain
Frequency of early in utero HIV-1 infection: a blind DNA polymerase chain reaction study on 100 fetal thymuses.: AIDS. 1995 Apr;9(4):359-66. Unique Identifier : AIDSLINE MED/95314791; Brossard Y; Aubin JT; Mandelbrot L; Bignozzi C; Brand D; Chaput A; Roume J; Mulliez N; Mallet F; Agut H; et al; Centre for Perinatal Haemobiology, Pitie-Salpetriere Hospital,; Paris, France.; OBJECTIVE: To estimate the prevalence of in utero transmission of HIV-1 through the second trimester. MATERIAL AND METHODS: One hundred consecutive, unselected, intact fetuses, beyond 15 weeks gestational age (mean, 22.4 weeks) were studied. These were obtained following spontaneous intrauterine deaths (n = 4), miscar
Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa.: AIDS. 1995 Apr;9(4):367-73. Unique Identifier : AIDSLINE MED/95314792; Snijders F; van Deventer SJ; Bartelsman JF; den Otter P; Jansen J; Mevissen ML; van Gool T; Danner SA; Reiss P; Division of Infectious Diseases, Tropical Medicine and AIDS,; University of Amsterdam, The Netherlands.; OBJECTIVE: To determine whether a mucosal cytokine-mediated inflammatory response is involved in cryptosporidial or microsporidial diarrhoea, as well as in diarrhoea of unknown origin in HIV-infected patients. DESIGN: Prospective study. METHODS: Jejunal biopsies were obtained from HIV-infected patients with diarrhoea.
Validating population surveys for the measurement of HIV/STD prevention indicators.: AIDS. 1995 Apr;9(4):375-82. Unique Identifier : AIDSLINE MED/95314793; Konings E; Bantebya G; Carael M; Bagenda D; Mertens T; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; OBJECTIVE: To validate the World Health Organization /Global Programme on AIDS (GPA) protocol for measuring HIV/sexually transmitted disease prevention indicators pertaining to knowledge and sexual practices of the general population. METHODS: Data were collected in
Sociodemographic predictors and temporal trends of extrapulmonary tuberculosis as an AIDS-defining disease in Spain.: AIDS. 1995 Apr;9(4):383-8. Unique Identifier : AIDSLINE MED/95314794; Castilla J; Gutierrez-Rodriguez A; Tello O; National Centre for Epidemiology, Carlos III Institute of Health,; Madrid, Spain.; OBJECTIVE: To identify the factors associated with the presentation of extrapulmonary tuberculosis (EPTB) in AIDS diagnosis and to analyse its temporal trend. DESIGN: Analysis of AIDS surveillance data. METHODS: The study was based on AIDS cases diagnosed in Spain between 1988 and 1
HIV-1 prevalence and risk factors among sexually transmitted disease clinic attenders in Trinidad.: AIDS. 1995 Apr;9(4):389-94. Unique Identifier : AIDSLINE MED/95314795; Cleghorn FR; Jack N; Murphy JR; Edwards J; Mahabir B; Paul R; White F; Bartholomew C; Blattner WA; Viral Epidemiology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland, USA.; OBJECTIVES: To study trends in prevalence and to ascertain risk factors for HIV-1 among sexually transmitted disease (STD) clinic attenders in Trinidad . DESIGN AND METHODS: Serial cross-sectional studies were conducted in 1987-1988
Myeloradiculitis due to Cryptococcus curvatus in AIDS [letter]: AIDS. 1995 Apr;9(4):395-6. Unique Identifier : AIDSLINE MED/95314796; Dromer F; Moulignier A; Dupont B; Gueho E; Baudrimont M; Improvisi L; Provost F; Gonzalez-Canali G
Contribution of breastfeeding to the reported variation in rates of mother-to-child HIV transmission [letter; comment]: AIDS. 1995 Apr;9(4):396-7. Unique Identifier : AIDSLINE MED/95314797; Nieburg P; Hu DJ; Moses S; Nagelkerke N
Is AIDS-related cryptococcosis more frequent among men? [letter]: AIDS. 1995 Apr;9(4):397-8. Unique Identifier : AIDSLINE MED/95314798; Manfredi R; Rezza G; Coronado VG; Cozzi Lepri A; Coronado OV; Mastroianni A; Chiodo F
Low prevalence of HIV-1 proviral DNA in peripheral blood monocytes and dendritic cells from HIV-1-infected individuals [letter]: AIDS. 1995 Apr;9(4):398-9. Unique Identifier : AIDSLINE MED/95314799; Hsia K; Tsai V; Zvaifler NJ; Spector SA
HIV-1 V3 envelope sequences required for macrophage infection [letter]: AIDS. 1995 Apr;9(4):399-401. Unique Identifier : AIDSLINE MED/95314800; Henkel T; Westervelt P; Ratner L
Willingness of dentists to treat an HIV-infected patient [letter]: AIDS. 1995 Apr;9(4):402-3. Unique Identifier : AIDSLINE MED/95314801; Porter SR; el-Maaytah M; Scully C; Afonso W; Leung T
Cerebral astrocytoma in HIV-infected patients [letter]: AIDS. 1995 Apr;9(4):403-4. Unique Identifier : AIDSLINE MED/95314802; Gervasoni C; Ridolfo AL; Rocca A; Vago L; d'Arminio Monforte A
Does zidovudine cause non-Hodgkin's lymphoma? [letter]: AIDS. 1995 Apr;9(4):404-5. Unique Identifier : AIDSLINE MED/95314803; Cote TR; Biggar RJ
Serum levels of interleukin-12 in adult and paediatric patients with HIV-1 infection [letter]: AIDS. 1995 Apr;9(4):405-6. Unique Identifier : AIDSLINE MED/95314804; Torre D; Zeroli C; Ferrario G; Bonetta G; Giola M; Speranza F; Fiori GP
Trimethoprim-sulphamethoxazole rechallenge in 20 previously allergic HIV-infected patients after homeopathic [letter]: AIDS. 1995 Apr;9(4):407-8. Unique Identifier : AIDSLINE MED/95314805; Bissuel F; Cotte L; Crapanne JB; Rougier P; Schlienger I; Trepo C
Statistics from the World Health Organization.: AIDS. 1995 Apr;9(4):409-10. Unique Identifier : AIDSLINE MED/95314806
An economic analysis of AIDS--towards a proposed model of costing: a Singapore experience.: Asia Pac J Public Health. 1994;7(3):143-50. Unique Identifier : AIDSLINE MED/95314908; Lim JY; Chew BW; Phua KH; Ministry of Health, Singapore.; With the increasing prevalence of HIV infection/AIDS and the extending range of care and treatment, the economic implications of the various prevention and control strategies, and of treatment, have become the subject of interest to policy-makers, public health specialists and health economists. This paper presents an
AIDS-related lymphomas: from pathogenesis to pathology.: Br J Haematol. 1995 Jun;90(2):235-43. Unique Identifier : AIDSLINE MED/95315004; Gaidano G; Carbone A; Dipartimento di Scienze Biomediche e Oncologia Umana, Universita; di Torino, Ospedale San Luigi Gonzaga, Italy.
CD4+ but not CD8+ T cells are required for the induction of oral tolerance.: Int Immunol. 1995 Mar;7(3):501-4. Unique Identifier : AIDSLINE MED/95315099; Garside P; Steel M; Liew FY; Mowat AM; Department of Immunology, Western Infirmary, University of; Glasgow, UK.; It has been suggested that oral tolerance is mediated by CD8+ T lymphocytes, but the functional properties of these cells are unclear. Here we show that the induction of tolerance by feeding mice ovalbumin (OVA) does not prime antigen-specific class I MHC-restricted cytotoxic T cells in vivo. Indeed, such responses ar
Interaction of nucleolar protein B23 with peptides related to nuclear localization signals.: Biochemistry. 1995 Jun 27;34(25):8037-42. Unique Identifier : AIDSLINE MED/95315192; Szebeni A; Herrera JE; Olson MO; Department of Biochemistry, University of Mississippi Medical; Center, Jackson 39216-4505, USA.; Nucleolar protein B23 is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The interactions of various NLS-containing peptides with two B23 isoforms (B23.1 and B23.2) were examined using equilibrium dialysis and Scatchard analyses. The KD for protein
Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine splenocytes.: Biochim Biophys Acta. 1995 May 24;1236(1):39-50. Unique Identifier : AIDSLINE MED/95315244; Jenski LJ; Bowker GM; Johnson MA; Ehringer WD; Fetterhoff T; Stillwell W; Department of Biology, Indiana University-Purdue University at; Indianapolis, IN 46202-5132, USA.; Here we test whether the incorporation of docosahexaenoic acid (DHA, 22:6), an (n-3) fatty acid, into lymphocyte membranes affects the expression of the surface proteins Thy-1.2 and CD8. DHA was incorporated into splenocytes by three methods: feeding mice diets containing menhaden (fish) oil, fusing splenocytes with D
[Attitude of nursing personnel towards patients with AIDS: impact of an awareness program]: Sante Ment Que. 1994 Fall;19(2):191-209. Unique Identifier : AIDSLINE MED/95315309; Paquin L; Lapierre S; Jourdan-Ionescu C; The goal of this study was to evaluate the impact of an awareness program aimed at experienced personnel and personnel in training who provide healthcare services to patients with AIDS. The purpose of the program was to prepare healthcare staff psychically in working with patients. Six groups of approximately ten peop
Bacterial vaccine vectors and bacillus Calmette-Guerin.: Clin Infect Dis. 1995 Apr;20(4):1001-9. Unique Identifier : AIDSLINE MED/95315345; Cirillo JD; Stover CK; Bloom BR; Jacobs WR Jr; Barletta RG; Department of Microbiology and Immunology, Stanford University,; California, USA.; Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines. Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recomb
Cytomegalovirus ureteritis as a cause of renal failure in a child infected with the human immunodeficiency virus.: Clin Infect Dis. 1995 Apr;20(4):1040-3. Unique Identifier : AIDSLINE MED/95315348; Mueller BU; MacKay K; Cheshire LB; Choyke PL; Kitchen B; Widemann B; Pizzo PA; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland 20892, USA.; Cytomegalovirus ( CMV ) infection is common in patients infected with human immunodeficiency virus. Hemorrhagic cystitis and tubulointerstitial nephritis have been recognized as complications of CMV infection, and these complications lead to hematuria and compromi
Bartonella (Rochalimaea) species as a cause of apparent culture-negative endocarditis.: Clin Infect Dis. 1995 Apr;20(4):1044-7. Unique Identifier : AIDSLINE MED/95315349; Spach DH; Kanter AS; Daniels NA; Nowowiejski DJ; Larson AM; Schmidt RA; Swaminathan B; Brenner DJ; Department of Medicine, University of Washington Medical Center,; University of Washington School of Medicine, Seattle, USA.; Bartonella quintana (formerly Rochalimaea quintana) is a recently recognized cause of apparent culture-negative endocarditis. We describe a 39-year-old, homeless man who developed aortic valve endocarditis caused by B. quintana. He had a history of alcoholism and was seronegative for the human immunodeficiency virus.
Long-term resolution of disseminated Mycobacterium avium complex infection in a patient with AIDS [letter]: Clin Infect Dis. 1995 Apr;20(4):1067-8. Unique Identifier : AIDSLINE MED/95315357; Farber HW
Group C streptococcal bacteremia in patients infected with the human immunodeficiency virus [letter]: Clin Infect Dis. 1995 Apr;20(4):1075. Unique Identifier : AIDSLINE MED/95315363; Chalasani P; Jurado R; McGowan JE
Breakthrough cerebral toxoplasmosis in patients with AIDS who are being treated with clarithromycin [letter]: Clin Infect Dis. 1995 Apr;20(4):1076-7. Unique Identifier : AIDSLINE MED/95315364; Raffi F; Struillou L; Ninin E; Reliquet V; Billaud E; Milpied B
Primary coinfection with human immunodeficiency virus and cytomegalovirus presenting as acute rhabdomyolysis [letter]: Clin Infect Dis. 1995 Apr;20(4):1077-8. Unique Identifier : AIDSLINE MED/95315365; Ragnaud JM; Tahbaz A; Buisson M; Morlat P; Gin H; Coquet M; Aubertin J
Cytomegalovirus infections of the nervous system in patients with AIDS.: Clin Infect Dis. 1995 Apr;20(4):747-54. Unique Identifier : AIDSLINE MED/95315370; McCutchan JA; Department of Medicine, UCSD School of Medicine, USA.; Retinitis due to cytomegalovirus ( CMV ) infection is a widely recognized complication of advanced disease due to human immunodeficiency virus type 1 (HIV-1). Less appreciated are other neurological manifestations of CMV infect
Effect of splenectomy on T lymphocyte subsets in patients infected with the human immunodeficiency virus.: Clin Infect Dis. 1995 Apr;20(4):768-71. Unique Identifier : AIDSLINE MED/95315373; Zurlo JJ; Wood L; Gaglione MM; Polis MA; Division of Infectious Diseases, Milton S. Hershey Medical; Center, Hershey, Pennsylvania 17033, USA.; A case-control study was conducted at two institutions to determine whether the absolute CD4 lymphocyte count or the percentage of lymphocytes bearing the CD4 marker (i.e., the CD4 percentage) is a more accurate indicator of underlying immune status in splenectomized patients infected with human immunodeficiency virus
Growth-deficient mycobacteria in patients with AIDS: diagnosis by analysis of DNA amplified from blood or tissue.: Clin Infect Dis. 1995 Apr;20(4):772-5. Unique Identifier : AIDSLINE MED/95315374; Emler S; Bottger EC; Broers B; Cassis I; Perrin L; Hirschel B; Division des Maladies Infectieuses, Hopital Cantonal; Universitaire de Geneve, Switzerland.; Amplification and sequencing of mycobacterial ribosomal RNA genes (16S rDNA) may permit the detection of growth-deficient species (i.e., those exhibiting no growth or those whose growth is delayed for more than 12 weeks). Of blood samples from 26 patients with AIDS and a liver sample from one additional AIDS patient,
Rapid oral desensitization to trimethoprim-sulfamethoxazole (TMP-SMZ): use in prophylaxis for Pneumocystis carinii pneumonia in patients with AIDS who were previously intolerant to TMP-SMZ.: Clin Infect Dis. 1995 Apr;20(4):849-53. Unique Identifier : AIDSLINE MED/95315386; Gluckstein D; Ruskin J; Department of Internal Medicine, Kaiser Permanente Medical; Center, Los Angeles, California 90027, USA.; Trimethoprim-sulfamethoxazole (TMP-SMZ) is the drug of choice as prophylaxis for Pneumocystis carinii pneumonia in patients with AIDS. However, adverse reactions ascribed to TMP-SMZ are common in such patients. We previously described a rapid method of oral TMP-SMZ desensitization in patients with AIDS and varying deg
Fever of uncertain origin in patients infected with the human immunodeficiency virus.: Clin Infect Dis. 1995 Apr;20(4):872-5. Unique Identifier : AIDSLINE MED/95315390; Miralles P; Moreno S; Perez-Tascon M; Cosin J; Diaz MD; Bouza E; Department of Clinical Microbiology and Infectious Diseases,; Hospital General Gregorio Maranon, Madrid, Spain.; To assess the frequency and etiology of fever of uncertain origin (FUO) in patients infected with the human immunodeficiency virus (HIV) and to evaluate the yield of diagnostic procedures used in their evaluation, we reviewed the clinical charts of all patients admitted to an AIDS unit during a 15-month period. FUO wa
Isolated peripheral tuberculous lymphadenitis in adults: current clinical and diagnostic issues.: Clin Infect Dis. 1995 Apr;20(4):876-82. Unique Identifier : AIDSLINE MED/95315391; Artenstein AW; Kim JH; Williams WJ; Chung RC; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; Eight cases of isolated peripheral tuberculous lymphadenitis occurred over a 16-month period at our institution, prompting a literature review to establish the epidemiology, clinical manifestations, and current approaches to diagnosis and treatment of this disorder. It occurs most commonly in young adult women who eit
Tuberculous pancreatic abscess as an initial AIDS-defining disorder in a patient infected with the human immunodeficiency virus: case report and review.: Clin Infect Dis. 1995 Apr;20(4):890-4. Unique Identifier : AIDSLINE MED/95315393; Jaber B; Gleckman R; Department of Medicine, Carney Hospital, Boston, Massachusetts; 02124, USA.; Tuberculosis (TB) is the most common opportunistic infection worldwide in human immunodeficiency virus (HIV)-infected patients. Intraabdominal TB includes lymphadenopathy and focal lesions of solid viscera. Symptomatic expression of tuberculous invasion of the pancreas (supplemented by demonstration of a mass on imagi
Fungemia in children infected with the human immunodeficiency virus: new epidemiologic patterns, emerging pathogens, and improved outcome with antifungal therapy.: Clin Infect Dis. 1995 Apr;20(4):900-6. Unique Identifier : AIDSLINE MED/95315395; Walsh TJ; Gonzalez C; Roilides E; Mueller BU; Ali N; Lewis LL; Whitcomb TO; Marshall DJ; Pizzo PA; Infectious Diseases Section, National Cancer Institute, Bethesda,; Maryland 20892, USA.; We characterized 27 episodes of fungemia in 22 children infected with the human immunodeficiency virus (HIV). Fungemia in these patients presented as a community-acquired infection in the setting of outpatient total parenteral nutrition or intravenous antibiotic therapy through a chronically indwelling central venous
Failure of treatment for chancroid in Rwanda is not related to human immunodeficiency virus infection: in vitro resistance of Haemophilus ducreyi to trimethoprim-sulfamethoxazole.: Clin Infect Dis. 1995 Apr;20(4):924-30. Unique Identifier : AIDSLINE MED/95315399; Bogaerts J; Kestens L; Martinez Tello W; Akingeneye J; Mukantabana V; Verhaegen J; Van Dyck E; Piot P; Laboratory of Microbiology (Centre Hospitalier de Kigali),; Belgo-Rwandan Medical Cooperation.; A comparative open study was performed to evaluate the efficacy of single doses of ciprofloxacin (500 mg) and trimethoprim-sulfamethoxazole (TMP-SMZ; 640 mg/3,200 mg) for the treatment of culture-proven chancroid. Clinical cure or improvement was observed 7 days after treatment in 32 (76.2%) of the 42 patients who rec
Abdominal tuberculosis in patients infected with the human immunodeficiency virus.: Clin Infect Dis. 1995 Apr;20(4):938-44. Unique Identifier : AIDSLINE MED/95315401; Fee MJ; Oo MM; Gabayan AE; Radin DR; Barnes PF; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033, USA.; We compared the presentation of abdominal tuberculosis in 43 patients infected with the human immunodeficiency virus (HIV) and in 35 patients without HIV infection. Fever, weight loss, and extraabdominal lymphadenopathy were more common in HIV-infected patients, whereas ascites and jaundice were more frequent in patie
1993 Sexually transmitted diseases treatment guidelines. Atlanta, Georgia, 19-21 January 1993.: Clin Infect Dis. 1995 Apr;20 Suppl 1:S1-109. Unique Identifier : AIDSLINE MED/95315408
Treatment of syphilis, 1993.: Clin Infect Dis. 1995 Apr;20 Suppl 1:S23-38. Unique Identifier : AIDSLINE MED/95315410; Rolfs RT; Division of STD/HIV Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Data on treatment of patients with syphilis were reviewed in preparation for revision of the Sexually Transmitted Disease Treatment Guidelines of the Centers for Disease Control and Prevention. Published studies of treatment regimens available and practical for use today were reviewed, particularly in regard to the fo
Early intervention for persons infected with human immunodeficiency virus.: Clin Infect Dis. 1995 Apr;20 Suppl 1:S3-22. Unique Identifier : AIDSLINE MED/95315411; Branson BM; Division of STD/HIV Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Early intervention for persons infected with human immunodeficiency virus (HIV) involves characterization of the stage of HIV disease, institution of therapy to prevent associated infections and postpone deterioration of immune function, and assistance in preventing transmission of the virus. This review examines the
Recommendations for treatment of chancroid, 1993.: Clin Infect Dis. 1995 Apr;20 Suppl 1:S39-46. Unique Identifier : AIDSLINE MED/95315412; Schulte JM; Schmid GP; Epidemiology Research Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA.; Since the 1989 Sexually Transmitted Diseases Treatment Guidelines were published by the Centers for Disease Control and Prevention, changes in the efficacy of the recommended and alternative regimens for the treatment of Haemophilus ducreyi infections have been described. Among recommended agents, erythromycin remains
Treatment options for vulvovaginal candidiasis, 1993.: Clin Infect Dis. 1995 Apr;20 Suppl 1:S80-90. Unique Identifier : AIDSLINE MED/95315416; Reef SE; Levine WC; McNeil MM; Fisher-Hoch S; Holmberg SD; Duerr A; Smith D; Sobel JD; Pinner RW; Centers for Disease Control and Prevention, Emerging Bacterial; and Mycotic Diseases Branch, Atlanta, Georgia 30333, USA.; Vulvovaginal candidiasis (VVC), the second most common form of vaginitis, particularly affects women of childbearing age. Since the 1970s, several new agents have become available for the treatment of VVC. This review focuses on options for the treatment of this condition, critically evaluating the relevant published
[Abdominal echography in patients with human immunodeficiency virus (HIV) infection. Diagnostic usefulness in the evaluation of associated medico-surgical pathology]: An Med Interna. 1995 Mar;12(3):115-21. Unique Identifier : AIDSLINE MED/95315422; Erdozain JC; Gonzalez Garcia M; Pintado V; Munoz JF; Castillo P; Presa M; Rodriguez JA; Segura JM; Unidad Ecografia Digestiva, Hospital La Paz, Madrid.; BASIS: The abdominal manifestations in the patient with HIV infection are increasingly frequent. We have conducted the present study in order to determine the diagnostic usefulness of the abdominal echography in the clinical assessment of the patient. MATERIALS AND METHODS: We review the echographic findings of 112 pa
[Oxidative stress and infectious pathology]: An Med Interna. 1995 Mar;12(3):139-49. Unique Identifier : AIDSLINE MED/95315428; Romero Alvira D; Guerrero Navarro L; Gotor Lazaro MA; Roche Collado E; Departement de Biochimie Clinique et de Diabetologie; Experimentale, CMU, Geneve, Switzerland.; Pathogenic organism can be considered as pro-oxidant agents because they produce cell death and tissue damage. In addition organism can be eliminated by specific cell defense mechanism which utilize in part, reactive oxygen radicals formed by oxidative stress responses. The cause of the necessarily defense process res
[Atypical presentation of Pneumocystis carinii pneumonia (letter)]: An Med Interna. 1995 Mar;12(3):151-2. Unique Identifier : AIDSLINE MED/95315431; Adrian M; Arranz R; Santos I; Noguerado A
Is the unpaid/paid donation debate for better or for worse?--advantages of unpaid donations.: Blood Coagul Fibrinolysis. 1994 Dec;5 Suppl 4:S27-8. Unique Identifier : AIDSLINE MED/95315439; Contreras M; North London Blood Transfusion Centre, UK.; It is suggested that the best quality blood and blood products are obtained from voluntary unpaid donations as these are given for genuine altruistic reasons. Voluntary donors have no reason to give false information about lifestyle factors which might place them at risk of transmitting infectious agents. There is the
Is self-sufficiency financially viable and ethically justifiable?--legal aspects.: Blood Coagul Fibrinolysis. 1994 Dec;5 Suppl 4:S37-8. Unique Identifier : AIDSLINE MED/95315442; Newdick C; Department of Law, University, Reading, UK.; There is no legislation specifically designed to compensate haemophilia patients who have been damaged by defective blood products. But there is a general regime, created as a result of the thalidomide tragedy, which deals with defective products . It was introduced at the European level by the European Directive on
Should clinical freedom be constrained in the name of self-sufficiency?: Blood Coagul Fibrinolysis. 1994 Dec;5 Suppl 4:S47-9. Unique Identifier : AIDSLINE MED/95315444; Schimpf K; German Haemophilia Society, Heidelberg.; Clinical freedom should enable a physician to decide in a free and unbiased manner which is the most appropriate therapy to use for a particular patient. In order to implement the four aims of the German Haemophilia Society an average of 4-4.5 units of Factor VIII per capita of the general population per year is neede
Do safety issues of plasma products constrain self-sufficiency?: Blood Coagul Fibrinolysis. 1994 Dec;5 Suppl 4:S67-70. Unique Identifier : AIDSLINE MED/95315447; Savidge GF; Haemophilia Reference Centre, Guy's & St Thomas' Hospital NHS; Trust, St Thomas' Hospital, London, UK.; The ultimate responsibility for selecting and administering plasma products to patients rests with the prescribing physician, and it is for him/her to choose the safest product available. However, liability for a product with a full licence rests exclusively with the licence holder. After the problems of HIV and hepat
[Detection of STLV-1 integration in DNA extracted from formalin-fixed and paraffin-embedded material from M. arctoides lymphoma by the polymerase chain reaction]: Biull Eksp Biol Med. 1995 Mar;119(3):314-6. Unique Identifier : AIDSLINE MED/95315516; Chikobava MG; Iakovleva LA; Indzhiia LV; Shattsel' G; Lapin BA
Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes.: Blood. 1995 Jul 1;86(1):250-7. Unique Identifier : AIDSLINE MED/95315544; Del Prete G; De Carli M; Lammel RM; D'Elios MM; Daniel KC; Giusti B; Abbate R; Romagnani S; Division of Clinical Immunology and Allergology, Istituto di; Clinica Medica 3, Florence, Italy.; The role of T-cell subsets in the induction of tissue factor (TF) production by human monocytes in vitro was investigated. Mitogen stimulation enabled both unfractionated T cells and their CD4+ or CD8+ subsets to promote procoagulant activity (PCA). After mitogen or antigen activation, all seven T-cell clones with Th1
Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection.: Blood. 1995 Jul 1;86(1):258-67. Unique Identifier : AIDSLINE MED/95315545; Aukrust P; Svardal AM; Muller F; Lunden B; Berge RK; Ueland PM; Froland SS; Medical Department A, University of Oslo, National Hospital,; Norway.; We investigated the intracellular glutathione redox status in isolated lymphocyte subpopulations and monocytes in patients with human immunodeficiency virus type 1 (HIV-1) infection and in healthy controls. CD4+ lymphocytes from HIV-1-infected patients were primarily characterized by a substantial increase in oxidized
Human/mouse radiation chimera are capable of mounting a human primary humoral response.: Blood. 1995 Jul 1;86(1):398-406. Unique Identifier : AIDSLINE MED/95315565; Marcus H; David M; Canaan A; Kulova L; Lubin I; Segall H; Denes L; Erlich P; Galun E; Gan J; et al; Department of Membrane Research and Biophysics, Weizmann; Institute of Science, Rehovot, Israel.; Lubin et al recently described a new approach that enables the generation of human/mouse chimera by adoptive transfer of human peripheral blood mononuclear cells (PBMC) into lethally irradiated normal strains of mice, radioprotected with bone marrow (BM) from donors with severe combined immune deficiency (SCID). In th
Inpatient hospice care: a new option for the terminally ill.: R I Med. 1995 Apr;78(4):118-9. Unique Identifier : AIDSLINE MED/95315629; Martin EW; Hospice Care of Rhode Island, Pawtucket 02860-3868, USA.
alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.: Glycoconj J. 1995 Feb;12(1):7-16. Unique Identifier : AIDSLINE MED/95315749; Rabehi L; Ferriere F; Saffar L; Gattegno L; Laboratoire de Biologie Cellulaire, Faculte de Medecine; Paris-Nord, Bobigny, France.; In the present study, we demonstrate a specific low-affinity interaction between recombinant precursor gp160 (rgp160) or surface unit gp120 (rgp120) of human immunodeficiency virus type 1 (HIV-1) and alpha 1-acid glycoprotein (AGP), a human glycoprotein displaying complex type N-glycans. Binding of rgp160/rgp120 to ag
Hepatitis C and haemophilia [editorial] [see comments]: BMJ. 1995 Jun 24;310(6995):1619-20. Unique Identifier : AIDSLINE MED/95315773; Lee CA
Chemoprophylaxis in tuberculosis and HIV infection [editorial]: BMJ. 1995 Jun 24;310(6995):1621-2. Unique Identifier : AIDSLINE MED/95315775; Walley J; Porter J
Strategies for dealing with problems associated with use of services for HIV infection and AIDS out of region: views of providers and users.: BMJ. 1995 Jun 24;310(6995):1636-8. Unique Identifier : AIDSLINE MED/95315785; Coyle A; McGrellis S; Department of Nursing and Midwifery, University of Surrey,; Guildford.; OBJECTIVES--To identify reasons why people with HIV infection and AIDS living within the former South West Thames Regional Health Authority use HIV and AIDS services outside the region, and to identify strategies for dealing with the problems associated with such use. DESIGN--Qualitative study consisting of interviews
Mortality among HIV-infected intravenous drug addicts in Stockholm in relation to methadone treatment.: Addiction. 1995 May;90(5):711-6. Unique Identifier : AIDSLINE MED/95315846; Fugelstad A; Rajs J; Bottiger M; Gerhardsson de Verdier M; Psychiatric Dependency Clinic, St Goran's Hospital, Stockholm,; Sweden.; The aim of the study was to estimate the mortality rate and evaluate the causes of death in all diagnosed HIV-positive IDUs in the Stockholm area, 1986-90, and to compare the risk of death of those who received methadone treatment with that of those never admitted to or discharged from the programme. Data were collect
Involvement of anterior chamber angle structures in disseminated histoplasmosis: report of three cases.: Ger J Ophthalmol. 1995 Mar;4(2):107-15. Unique Identifier : AIDSLINE MED/95315848; Font RL; Parsons MA; Keener MJ; Shaver RP; Foos RY; Department of Ophthalmology, Cullen Eye Institute, Baylor College; of Medicine, Houston, TX 77030, USA.; This study describes the involvement of anterior chamber (AC) angle structures in patients with disseminated histoplasmosis. The postmortem eyes from three patients (aged 33, 41, and 42 years, respectively) with disseminated histoplasmosis, two of whom had acquired immunodeficiency syndrome, were examined by light mic
Integrated case management: the AID Atlanta Model.: J Case Manag. 1995 Spring;4(1):15-21. Unique Identifier : AIDSLINE MED/95315879; Sowell RL; Grier J; This article describes the integrated case management model being developed by AID Atlanta, Inc., a community-based AIDS service organization. The case management system features centralized supervision and coordination with decentralized delivery of case management services that avoid duplication of services. The mod
A case management program for chemically dependent clients with multiple needs.: J Case Manag. 1995 Spring;4(1):22-8. Unique Identifier : AIDSLINE MED/95315881; Brindis C; Pfeffer R; Wolfe A; As part of a 3-year federal demonstration project, San Francisco health clinics provided case management services to chemically dependent individuals who were low-income and often homeless. Many of those participating in the project had also been diagnosed with HIV infection and/or mental illness. The intent of the de
[AIDS Commission]: Bull Mem Acad R Med Belg. 1994;149(5-7):226. Unique Identifier : AIDSLINE MED/95315887
IgA antiphospholipid antibodies in HTLV-1-associated tropical spastic paraparesis.: Lupus. 1995 Apr;4(2):138-41. Unique Identifier : AIDSLINE MED/95315960; Wilson WA; Morgan Ost C; Barton EN; Smikle M; Hanchard B; Blattner WA; Doggett S; Gharavi AE; Department of Medicine, Lousiana State University Medical Center,; New Orleans 70112, USA.; A retrovirus, human T cell lymphotropic virus type 1 (HTLV-1), is an essential but not a sufficient aetiologic factor for tropical spastic paraparesis (TSP). Because some TSP patients have biological false positive tests for treponemal infections (BFP-STS), we used ELISA to study BFP-STS and anticardiolipin antibodies
Lentiviral infection, immune response peptides and sleep.: Adv Neuroimmunol. 1995;5(1):57-77. Unique Identifier : AIDSLINE MED/95316270; Darko DF; Mitler MM; Henriksen SJ; Scripps Research Institute, La Jolla, CA 92037-1027, USA.; The aberrant sleep documented in subjects with human immunodeficiency virus (HIV) infection is uniquely important because of the contribution this poor quality sleep makes to the fatigue, disability, and eventual unemployment that befalls these patients. Especially given this importance in clinical care, the research
Synthesis and anti-HIV activity of new urea and nitrosourea derivatives of diamino acids.: Bioorg Med Chem. 1995 Feb;3(2):151-60. Unique Identifier : AIDSLINE MED/95316428; Dulude H; Salvador R; Gallant G; Medicinal Chemistry Laboratory, Faculty of Pharmacy, University; of Montreal, Quebec, Canada.; A series of N1-methyl,N1-allyl,N1-(2-chloroethyl) and N1-propargyl urea and nitrosourea derivatives of diamino acids (L-ornithine and L-lysine) was synthesized and was shown to have weak activity in counteracting the cytopathic effects of the HIV-1 on a T4 lymphocyte cell line (CEM-IW). However, selected compounds may
Bronchoalveolar lavage in pulmonary tuberculosis: a decision analysis approach.: QJM. 1995 Apr;88(4):269-76. Unique Identifier : AIDSLINE MED/95316460; Mohan A; Pande JN; Sharma SK; Rattan A; Guleria R; Khilnani GC; Department of Medicine, All India Institute of Medical Sciences,; New Delhi.; We assessed the utility of bronchoalveolar lavage (BAL) in the diagnosis of pulmonary tuberculosis (PTB) in 50 consecutive HIV-negative patients with clinical and radiographic findings suggestive of PTB, but with negative microscopy for acid-fast bacilli (AFB) on sputum smear. Patients were grouped, using a scoring sy
Fever as the presenting complaint of travellers returning from the tropics.: QJM. 1995 Apr;88(4):277-81. Unique Identifier : AIDSLINE MED/95316461; Doherty JF; Grant AD; Bryceson AD; Hospital for Tropical Diseases, London, UK.; We investigated prospectively the cause of fever in patients requiring hospitalization after returning from the tropics. All consecutive admissions (n = 195) with oral temperature > 37.0 degrees C at the time of admission were enrolled. Final diagnosis as recorded on the discharge summary by the attending physician an
Serodiagnosis of pericardial tuberculosis.: QJM. 1995 May;88(5):317-20. Unique Identifier : AIDSLINE MED/95316468; Ng TT; Strang JI; Wilkins EG; Monsall Unit, North Manchester General Hospital, UK.; The AIDS epidemic has led to the resurgence of tuberculosis. Extrapulmonary manifestations may appear in over half of the patients who are dually infected. This has resulted in a rising incidence of tuberculous pericarditis in several parts of Africa such as Tanzania . We tested a
Use of a brief behavioral skills intervention to prevent HIV infection among chronic mentally ill adults.: Psychiatr Serv. 1995 Mar;46(3):275-80. Unique Identifier : AIDSLINE MED/95316628; Kalichman SC; Sikkema KJ; Kelly JA; Bulto M; Center for AIDS Intervention Research, Medical College of; Wisconsin, Milwaukee 53226, USA.; OBJECTIVE: Research shows that many chronic psychiatric patients are at risk for infection by the human immunodeficiency virus (HIV). This study investigated the effects of a behavioral skills training program designed to prevent HIV infection among chronic mentally ill adults living in an inner-city area. METHODS: Tw
The Charles Bonnet syndrome: a brief review and case report.: Psychiatr Serv. 1995 Mar;46(3):289-91. Unique Identifier : AIDSLINE MED/95316633; Maricle RA; Turner LD; Lehman KD; Department of Psychiatry, Oregon Health Sciences University,; Portland 97201, USA.; A case of a woman with visual hallucinations in the absence of other organic or psychiatric findings--symptoms consistent with a diagnosis of Charles Bonnet syndrome--is reported. The women was HIV positive, although asymptomatic for conventional complications of HIV infection. After considering possible causes of the
The importance of being floppy [news; comment]: Nat Struct Biol. 1995 Apr;2(4):255-7. Unique Identifier : AIDSLINE MED/95316670; Wagner G
Flexibility and function in HIV-1 protease [see comments]: Nat Struct Biol. 1995 Apr;2(4):274-80. Unique Identifier : AIDSLINE MED/95316676; Nicholson LK; Yamazaki T; Torchia DA; Grzesiek S; Bax A; Stahl SJ; Kaufman JD; Wingfield PT; Lam PY; Jadhav PK; et al; Molecular Structural Biology Unit, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland; 20892, USA.; HIV protease is a homodimeric protein whose activity is essential to viral function. We have investigated the molecular dynamics of the HIV protease, thought to be important for proteinase function, bound to high affinity inhibitors using NMR techniques. Analysis of 15N spin relaxation parameters, of all but 13 backbo
Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics.: Nat Struct Biol. 1995 Apr;2(4):334-8. Unique Identifier : AIDSLINE MED/95316683; Collins JR; Burt SK; Erickson JW; Structural Biochemistry Program, Frederick Biomedical; Supercomputing Center, PRI/DynCorp, National Cancer Institute -; Frederick Cancer Research and Development Center, Maryland; 21702-1201, USA.; We have used an activated molecular dynamics approach to simulate flap opening in HIV-1 protease. An initial impulse for flap opening was provided by applying harmonic constraints to non-flap residues. After an initial melting phase, the two beta-hairpin structures that constitute the flaps opened to a 25 A gap wi
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.: Immunity. 1995 Jun;2(6):665-75. Unique Identifier : AIDSLINE MED/95316722; Szabo SJ; Jacobson NG; Dighe AS; Gubler U; Murphy KM; Department of Pathology, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.; Developmental-commitment to Th1 or Th2 responses critically influences host susceptibility to particular pathogens. We describe a novel mechanism governing stable commitment to Th2 differentiation. Naive T cells develop strongly polarized Th1 and Th2 profiles by 7 days after activation. However, commitment of these de
[Discovery of HTLV-I associated myelopathy]: Nihon Shinkei Seishin Yakurigaku Zasshi. 1995 Apr;15(2):185-9. Unique Identifier : AIDSLINE MED/95316749; Igata A; National Chubu Hospital, Aichi, Japan.
Hemophilia and von Willebrand's disease: 1. Diagnosis, comprehensive care and assessment. Association of Hemophilia Clinic Directors of Canada.: Can Med Assoc J. 1995 Jul 1;153(1):19-25. Unique Identifier : AIDSLINE MED/95316809; OBJECTIVE: To present current strategies for the assessment and comprehensive care of patients with hemophilia and von Willebrand s disease. OPTIONS: Hospital care, home care, single-provider care and multidisciplinary care. OUTCOMES: Morbidity and quality of life associated with bleeding and treatment. EVIDENCE: Rele
Acquired immunodeficiency syndrome enteropathy: a perspective.: Compr Ther. 1995 Apr;21(4):184-8. Unique Identifier : AIDSLINE MED/95317038; Craig RM; Carlson S; Ehrenpreis E; Department of Medicine, Northwestern University Medical Center,; Chicago, Illinois 60611, USA.
The role of superantigens in the immunobiology of retroviruses.: Ciba Found Symp. 1994;187:132-40; discussion 140-3. Unique Identifier : AIDSLINE MED/95317139; Huber BT; Beutner U; Subramanyam M; Department of Pathology, Tufts University School of Medicine,; Boston, MA 02111, USA.; Murine mammary tumour viruses (MMTVs) are retroviruses that encode superantigens capable of stimulating T cells via superantigen-reactive T cell receptor V beta chains. MMTVs are transmitted to the suckling offspring via the milk. We have established that class II and B cell-deficient mice that were foster nursed by v
Genetic modification of T cell clones to improve the safety and efficacy of adoptive T cell therapy.: Ciba Found Symp. 1994;187:212-23; discussion 224-8. Unique Identifier : AIDSLINE MED/95317145; Greenberg PD; Nelson B; Gilbert M; Sing A; Yee C; Jensen M; Riddell SR; Department of Medicine, University of Washington, Seattle 98195,; USA.; Our laboratory has developed methods to isolate human antigen-specific cytolytic CD8+ T cell clones and to expand such clones in vitro to numbers sufficient for T cell therapy of human diseases. Studies in immunocompromised bone marrow transplant patients at high risk for disease associated with
Human T cell lymphotropic virus: necessity for and feasibility of a vaccine.: Ciba Found Symp. 1994;187:47-55; discussion 55-60. Unique Identifier : AIDSLINE MED/95317149; de The G; Bomford R; Kazanji M; Ibrahim F; Departement des Retrovirus, Institut Pasteur, Paris, France.; Human T cell lymphotropic virus types I and II (HTLV-I/II) are endemic in certain areas of the world. They cause two life-threatening diseases, adult T cell leukaemia/lymphoma and tropical spastic paraparesis. A vaccine is needed because in developing countries there are no other feasible preventive interventions agai
Antiherpetic activities of N-alpha-acetyl-nona-D-arginine amide acetate.: Drugs Exp Clin Res. 1995;21(1):1-6. Unique Identifier : AIDSLINE MED/95317183; Sumner-Smith M; Zheng Y; Zhang YP; Twist EM; Climie SC; Allelix Biopharmaceuticals Inc., Mississauga, Ontario, Canada.; N-alpha-acetyl-nona-D-arginine amide acetate (ALX40-4C) was developed as a competitive inhibitor of the binding of the HIV Tat protein to its RNA target TAR, which is an intracellular interaction dependent on a short, arginine-rich sequence in Tat. ALX40-4C is a simple mimic of that domain, which is stabilised against
Adherence to zidovudine (AZT) among HIV-infected methadone patients: a pilot study of supervised therapy and dispensing compared to usual care.: Drug Alcohol Depend. 1995 Mar;37(3):261-9. Unique Identifier : AIDSLINE MED/95317197; Wall TL; Sorensen JL; Batki SL; Delucchi KL; London JA; Chesney MA; University of California, San Francisco, San Francisco General; Hospital 94110, USA.; Twenty-seven HIV-infected methadone maintenance patients who demonstrated problems adhering to zidovudine ( AZT ) were randomly assigned to a group that received eight weeks of weekday supervised therapy and dispensing of AZT or a group that received us
AIDS in the field of otolaryngology.: Ear Nose Throat J. 1995 May;74(5):328. Unique Identifier : AIDSLINE MED/95317215; Tami TA
AIDS: lessons from the last decade and prospects for the future.: Ear Nose Throat J. 1995 May;74(5):329-34, 336. Unique Identifier : AIDSLINE MED/95317216; Sharma PK; Tami TA; University of Cincinnati, Department of Otolaryngology-Head and; Neck Surgery, Ohio, USA.
Universal precautions for the otolaryngologist: techniques and equipment for minimizing exposure risk.: Ear Nose Throat J. 1995 May;74(5):338, 341-6. Unique Identifier : AIDSLINE MED/95317217; Murr AH; Lee KC; Department of Otolaryngology/Head and Neck Surgery, University of; California, San Francisco, USA.; HIV infection transmitted from a patient to a surgeon is a real concern but a remote possibility. However, given the professional and personal impact of HIV seroconversion on a physician, preventive measures need to be instituted. The CDC has developed a policy of universal precautions to help to minimize this risk. W
OSHA standards for blood-borne pathogens--strategies to increase compliance among otolaryngologists.: Ear Nose Throat J. 1995 May;74(5):348-52. Unique Identifier : AIDSLINE MED/95317218; Wagner RL; Johnson JT; Department of Otolaryngology, University of Pittsburgh School of; Medicine, PA 15213, USA.
Audiological changes associated with HIV infection.: Ear Nose Throat J. 1995 May;74(5):353-9. Unique Identifier : AIDSLINE MED/95317219; Bankaitis AE; Keith RW; University of Cincinnati Medical Center, Department of; Otolaryngology-Head and Neck Surgery, Ohio, USA.
The management of sinusitis in patients infected with the human immunodeficiency virus (HIV).: Ear Nose Throat J. 1995 May;74(5):360-3. Unique Identifier : AIDSLINE MED/95317220; Tami TA; Department of Otolaryngology-Head and Neck Surgery, University of; Cincinnati, Ohio, USA.; As the Human Immunodeficiency Virus (HIV) has extended its influence across the United States , otolaryngologists have been increasingly called upon to manage its various head and neck manifestations. Sinusitis is a very prevalent, yet difficult, management problem in this patient popul
The human immunodeficiency virus and facial plastic surgery.: Ear Nose Throat J. 1995 May;74(5):364-8. Unique Identifier : AIDSLINE MED/95317221; Maas CS; Sussman SA; Hewett JJ; Department of Otolaryngology-Head and Neck Surgery, University of; California, San Francisco 94143-0342, USA.; The Human Immunodeficiency Virus (HIV) has imparted a number of concerns involving patient care and management as well as health care worker safety upon most surgical practices. Although these concerns are not often discussed in the context of facial plastic surgery (or particularly cosmetic surgery), they remain impo
Bacteraemia in patients presenting with fever.: East Afr Med J. 1995 Feb;72(2):116-20. Unique Identifier : AIDSLINE MED/95317226; Petit PL; Haarlem JV; Poelman M; Haverkamp MC; Wamola IA; Department of Microbiology, University Hospital Leiden, The; Netherlands.; In three studies, in Ghana and Kenya , blood from 639 patients admitted with fever was cultured. Standard treatments were antimalarials (54-100%) and antibiotics (39-90%). According to the criteria in use, however, only 10-31% had malaria alone; of
Orofacial lesions as indicators of HIV/AIDS among dental patients in Kenya.: East Afr Med J. 1995 Feb;72(2):135-8. Unique Identifier : AIDSLINE MED/95317232; Guthua SW; Mwaniki DL; Chindia ML; University of Nairobi, College of Health Sciences, Department of; Dental Surgery.; Despite an estimated prevalence of 3-5% of HIV infection in Kenya , little has been reported on the occurrence of oral lesions amongst the afflicted individuals. We report ten cases who presented with orofacial lesions and subsequent serological evaluation confirmed them seropositive
Combined use of condoms with other contraceptive methods among inner-city Baltimore women.: Fam Plann Perspect. 1995 Mar-Apr;27(2):74-8. Unique Identifier : AIDSLINE MED/95317402; Santelli JS; Davis M; Celentano DD; Crump AD; Burwell LG; Baltimore City Health Department, Department of Health Policy; Management, Johns Hopkins School of Hygiene and Public Health,; Baltimore, MD, USA.; Data from a street survey conducted among 717 women aged 17-35 in two inner-city Baltimore communities in 1991-1992 indicate that 17% of the entire sample, 38% of women using the pill and 11% of users of methods other than the pill used a condom in addition to another method the last time they had intercourse. Althoug
A kinetic model for comparing proteolytic processing activity and inhibitor resistance potential of mutant HIV-1 proteases.: FEBS Lett. 1995 Jun 26;367(2):112-6. Unique Identifier : AIDSLINE MED/95317407; Tang J; Hartsuck JA; Protein Studies Program, Oklahoma Medical Research Foundation,; Oklahoma City 73104, USA.; A kinetic model is presented for the comparison of potential proteolytic processing activities of wild-type and mutant human immunodeficiency virus proteases in the presence and absence of protease inhibitors . The protease processing of gag substrate in the immature
Adenovirus as vector for HIV: efficacy and safety issues.: Dev Biol Stand. 1995;84:153-6. Unique Identifier : AIDSLINE MED/95317466; Natuk RJ; Wade MS; Chengalvala M; Murthy KK; Chanda PK; Murthy SC; Bhat BM; Bhat R; Dheer SK; Mizutani S; et al; Wyeth-Ayerst Research, Biotechnology and Microbiology Division,; Philadelphia, PA, USA.
The safety and use of canarypox vectored vaccines.: Dev Biol Stand. 1995;84:165-70. Unique Identifier : AIDSLINE MED/95317468; Plotkin SA; Cadoz M; Meignier B; Meric C; Leroy O; Excler JL; Tartaglia J; Paoletti E; Gonczol E; Chappuis G; Pasteur-Merieux Serums et Vaccins, Marnes-la Coquette, France.; ALVAC recombinants have been administered to humans and animals by parenteral and oral routes without giving signs of replication, systemic dissemination or severe reaction. In principle, it should be impossible for canarypox recombinants to disseminate in the environment as they would not be synthesised in mammalian
The history of live bacterial vaccines.: Dev Biol Stand. 1995;84:211-9. Unique Identifier : AIDSLINE MED/95317474; Lindberg AA; Lederle-Praxis Biologicals, Wayne, NJ, USA.; Recent developments have made it possible to construct non-reverting live bacterial vaccine candidates with defined deletions of two or more genes. Such vaccines have proven safe and immunogenic in human volunteers. Since the virulent parent strains are only pathogenic to man (S. typhi, S. flexneri, and V. cholerae),
Social organisation and SIV sero-epidemiology of a patas monkey population in Senegal.: Folia Primatol (Basel). 1994;63(4):226-8. Unique Identifier : AIDSLINE MED/95317710; Galat-Luong A; Bibollet-Ruche F; Pourrut X; Durand JP; Sarni P; Pichon G; Galat G; Laboratoire de Primatologie, ORSTOM, Dakar, Senegal.
Hepatosinusoidal leukaemia/lymphoma consisting of Epstein-Barr virus-containing natural killer cell leukaemia/lymphoma and T-cell lymphoma; mimicking malignant histiocytosis.: Hematol Oncol. 1995 Mar-Apr;13(2):83-97. Unique Identifier : AIDSLINE MED/95317736; Ohshima K; Kikuchi M; Mizuno S; Akashi K; Moriyama K; Yoneda S; Takeshita M; Shibata T; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; Previously diagnosed cases of hepatosinusoidal T-cell lymphoma and malignant histiocytosis (MH) may include lymphoid neoplasms of natural killer (NK) cell lineage associated with Epstein-Barr virus (EBV). Such hepatosinusoidal neoplasms were found to demonstrate hepatomegaly but not lymphadenopathy, and all were diagn
Productive in vitro infection of human umbilical vein endothelial cells and three colon carcinoma cell lines with HIV-1.: Immunol Cell Biol. 1995 Apr;73(2):140-5. Unique Identifier : AIDSLINE MED/95317783; Corbeil J; Evans LA; McQueen PW; Vasak E; Edward PD; Richman DD; Penny R; Cooper DA; Department of Pathology, University of California San Diego; 92093-0679, USA.; The objective of this study was to assess the ability of HIV-1 to establish an in vitro infection of primary human umbilical vein endothelial cells (HUVEC). The HUVEC and colon carcinoma cell lines were inoculated with different isolates of HIV-1 (HIV-1SF2, HIV-1Mck and HIV-1LAI) and productive viral infection was ass
Functional significance of CD23- on CD23-transfected Th2 clone.: Immunol Lett. 1995 Jan;44(2-3):163-7. Unique Identifier : AIDSLINE MED/95317800; Nambu M; Hagen M; Sandor M; Sacco RE; Kwack K; Lynch RG; Department of Pathology, College of Medicine, University of Iowa,; Iowa City 52242, USA.; CD23, a low-affinity IgE Fc receptor, is not displayed on most resting T cells but its expression has been shown to be transiently induced in vivo and in vitro on some CD4+ T cells [1-4] and in vivo on CD8+ T cells by IgE-secreting hybridoma tumors [5]. To investigate the functional role of CD23 on T cells, we inserte
Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells.: Immunol Lett. 1995 Jan;44(2-3):189-93. Unique Identifier : AIDSLINE MED/95317804; Sachi Y; Hirota K; Masutani H; Toda K; Okamoto T; Takigawa M; Yodoi J; Department of Biological Responses, Kyoto University, Japan.; Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of
Gastric wall necrosis in an HIV-positive patient.: Indian J Gastroenterol. 1995 Apr;14(2):76. Unique Identifier : AIDSLINE MED/95317841; Pai D; Ganesan G; Jayanthi S; Department of Surgery, Jawaharlal Nehru Institute of Postgraduate; Medical Education and Research, Pondicherry.; Perforation of the gastrointestinal tract is rare in HIV infection and occurs most often in the colon and small intestine. Gastric perforation in HIV-positive patients has not been reported so far. We report an HIV-positive patient who developed gastric perforation.
Modelling AIDS reduction strategies.: Int J Epidemiol. 1995 Feb;24(1):188-97. Unique Identifier : AIDSLINE MED/95317897; Kault DA; Anton Breinl Centre for Tropical Health and Medicine, James Cook; University, Townsville, Queensland, Australia.; BACKGROUND. Mathematical models of the AIDS epidemic have not been able to give accurate predictions about the size of the epidemic because it is not possible to obtain sufficiently accurate measurements of the factors that enable HIV transmission. The uncertainties inherent in models of the AIDS epidemic appear to li
Evidence of serological cross-reactivities with human immunodeficiency virus types 1 and 2 and human T-lymphotropic virus types I and II in sera of pregnant women in Ibadan, Nigeria.: Int J Epidemiol. 1995 Feb;24(1):198-203. Unique Identifier : AIDSLINE MED/95317899; Olaleye DO; Ekweozor CC; Sheng Z; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California, School of Medicine, Los Angeles 90032-3626,; USA.; BACKGROUND. Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-lymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria . These viruses are antigenically distinct and antibodies to HIV and HTLV do not
An outbreak of hepatitis A among homosexual men in Amsterdam, 1991-1993.: Int J Epidemiol. 1995 Feb;24(1):218-22. Unique Identifier : AIDSLINE MED/95317901; Leentvaar-Kuijpers A; Kool JL; Veugelers PJ; Coutinho RA; van Griensven GJ; Municipal Health Service, Department of Public Health and; Environment, Amsterdam, The Netherlands.; BACKGROUND. When in August 1992 it became evident that an outbreak of hepatitis A virus infections (HAV) was taking place in the male homosexual community in Amsterdam a case-control study was conducted to validate the assumption that the outbreak was associated with sexual practices involving oro-anal and digital-ana
Siamycins I and II, new anti-HIV peptides: I. Fermentation, isolation, biological activity and initial characterization [letter]: J Antibiot (Tokyo). 1995 May;48(5):433-4. Unique Identifier : AIDSLINE MED/95318018; Tsunakawa M; Hu SL; Hoshino Y; Detlefson DJ; Hill SE; Furumai T; White RJ; Nishio M; Kawano K; Yamamoto S; et al
HIV and AIDS: issues for women in Australia.: Health Care Women Int. 1995 May-Jun;16(3):221-8. Unique Identifier : AIDSLINE MED/95318023; Lucke JC; Raphael B; The major HIV/AIDS-related issues facing women in Australia are outlined. From a global epidemiological perspective, women in Australia have almost gone unscathed by HIV infection. However, the potential for widespread infection cannot be ignored. The greatest threat for the maj
Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression.: J Biol Chem. 1995 Jun 23;270(25):14891-8. Unique Identifier : AIDSLINE GENBANK/X82200; Tissot C; Mechti N; Institut de Genetique Moleculaire de Montpellier-UMR 9942, CNRS,; France.; Transcriptional induction of genes is an essential part of the cellular response to interferons. To isolate yet unidentified IFN-regulated genes we have performed a differential screening on a cDNA library prepared from human lymphoblastoid Daudi cells treated for 16 h with human alpha/beta interferon (Hu-alpha/beta I
gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family.: J Biol Chem. 1995 Jun 23;270(25):15022-8. Unique Identifier : AIDSLINE GENBANK/U25126; Kuroki K; Eng F; Ishikawa T; Turck C; Harada F; Ganem D; Department of Biophysics, Kanazawa University, Ishikawa, Japan.; Duck hepatitis B virus particles bearing the L and S envelope proteins bind a cellular glycoprotein of 180 kDa (gp180) with high affinity and specificity. Binding is mediated by the pre-S region of the L protein and is blocked by neutralizing but not by non-neutralizing monoclonal antibodies to the virus. These and ot
Cloning, bacterial expression, and characterization of the Mason-Pfizer monkey virus proteinase.: J Biol Chem. 1995 Jun 23;270(25):15053-8. Unique Identifier : AIDSLINE MED/95318063; Hruskova-Heidingsfeldova O; Andreansky M; Fabry M; Blaha I; Strop P; Hunter E; Institute of Organic Chemistry and Biochemistry, Czech Academy of; Sciences, Prague.; We have cloned and expressed the 3 region of the Mason- Pfizer monkey virus pro gene in Escherichia coli. The recombinant 26-kDa precursor undergoes rapid self-processing both in E. coli and in vitro at the NH2 terminus, yielding a proteolytically active 17-kDa protein, p1
A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity.: J Biol Chem. 1995 Jun 23;270(25):15307-14. Unique Identifier : AIDSLINE MED/95318099; Sawai ET; Baur AS; Peterlin BM; Levy JA; Cheng-Mayer C; Department of Medicine, University of California, San Francisco; 94143-0128, USA.; Among the primate lentiviruses (human immunodeficiency virus (HIV) -1, HIV-2, and simian immunodeficiency virus (SIV), the nef gene is highly conserved and encodes a myristylated protein of approximately 27 kDa (HIV-1) or approximately 34 kDa (HIV-2, SIV). Previously, we found Nef expressed either as a CD8-Nef fusion
Psychological stress and immunological responsiveness in normally cycling, follicular-stage women.: J Neuroimmunol. 1995 Jun;59(1-2):103-11. Unique Identifier : AIDSLINE MED/95318211; Caggiula AR; McAllister CG; Matthews KA; Berga SL; Owens JF; Miller AL; Department of Psychology, University of Pittsburgh, PA 15260,; USA.; Nineteen women in the follicular stage of their menstrual cycles were assessed for immunological responsiveness to a 50-min series of three psychological tasks which reliably elicit cardiovascular and neuroendocrine stress responses. Ten follicular-stage women not subjected to stress served as controls. Stress decreas
Anxiety in community-based AIDS caregivers before and after personal construct counseling.: J Clin Psychol. 1995 Mar;51(2):274-80. Unique Identifier : AIDSLINE MED/95318258; Viney LL; Crooks L; Walker BM; Department of Psychology, University of Wollongong, NSW,; Australia.; Personal construct counseling was provided for voluntary AIDS caregivers based in the community, with the goal of reducing their anxiety levels. Seventy-five caregivers participated in the project, 33 of whom received counseling. They were interviewed on three occasions--before, immediately after, and 3 months after c
Recurrent acute pancreatitis and pancreatic pseudocyst as the presenting manifestation of HIV infection.: J Clin Gastroenterol. 1995 Apr;20(3):261-2. Unique Identifier : AIDSLINE MED/95318453; Kordossis T; Kosmopoulou O; Tzavaras A; Anevlavis E; Department of Pathophysiology (AIDS Unit), Laiko General; Hospital, Medical School, University of Athens, Greece.
Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome.: J Infect Dis. 1995 Jul;172(1):105-12. Unique Identifier : AIDSLINE MED/95318508; Cossarizza A; Ortolani C; Mussini C; Borghi V; Guaraldi G; Mongiardo N; Bellesia E; Franceschini MG; De Rienzo B; Franceschi C; Department of Biomedical Sciences, University of Modena School of; Medicine, Italy.; In 8 patients with symptomatic, acute primary infection with human immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4+ lymphocytes was seen, accompanied by a marked increase in activated/memory CD8+ T cells (CD38+, CD45R0+, HLA-DR+, with high amounts of cell adhesion molecules), which represented
Crude extract and recombinant protein of Cryptosporidium parvum oocysts induce proliferation of human peripheral blood mononuclear cells in vitro.: J Infect Dis. 1995 Jul;172(1):211-6. Unique Identifier : AIDSLINE MED/95318525; Gomez Morales MA; Ausiello CM; Urbani F; Pozio E; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.; Cryptosporidium parvum preparations were studied for their ability to induce specific proliferation of cultured human peripheral blood mononuclear cells (PBMC) from both immunocompetent and human immunodeficiency virus-positive persons, some of whom had transient cryptosporidiosis. The proliferation of PBMC from sensi
Establishment of novel lymphoid cell lines dually infected with human T cell lymphotropic viruses types I and II.: J Infect Dis. 1995 Jul;172(1):220-4. Unique Identifier : AIDSLINE MED/95318527; Kubota T; Morishita N; Tanaka Y; Sawada T; Miyagi T; Ohtsuki Y; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; With the goal of establishing an in vitro system of dual infection with human T cell lymphotropic viruses (HTLV) types I and II, rabbit lymphocytes were cocultured with a mixture of lethally irradiated HTLV-I-producing Ra-1 and HTLV-II-producing RII cell lines. This gave rise to a lymphoid cell line, RW-1, that was du
Foscarnet decreases human immunodeficiency virus RNA.: J Infect Dis. 1995 Jul;172(1):225-7. Unique Identifier : AIDSLINE MED/95318528; Kaiser L; Perrin L; Hirschel B; Furrer H; Von Overbeck J; Olmari M; Yerly S; Division of Infectious Diseases, University Hospital, Geneva,; Switzerland.; Foscarnet inhibits human immunodeficiency virus (HIV) replication in vitro and decreases p24 antigenemia in patients with cytomegalovirus ( CMV ) retinitis. To evaluate the effect of foscarnet on HIV replication, HIV RNA was qu
Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.: J Infect Dis. 1995 Jul;172(1):228-31. Unique Identifier : AIDSLINE MED/95318529; Lederman MM; Jackson JB; Kroner BL; White GC 3rd; Eyster ME; Aledort LM; Hilgartner MW; Kessler CM; Cohen AR; Kiger KP; et al; Case Western Reserve University School of Medicine, Ohio, USA.; Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by
Transplantation of skin from human immunodeficiency virus type 1-transgenic mice to normal congenic mice results in graft rejection.: J Infect Dis. 1995 Jul;172(1):232-4. Unique Identifier : AIDSLINE MED/95318530; Dumois JA; VanderVegt FP; Kopp JB; Marinos NJ; Rooney JF; Notkins AL; Laboratory of Oral Medicine, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892-4322,; USA.; Skin from mice transgenic (Tg) for part of the human immunodeficiency virus type 1 (HIV-1) genome was transplanted onto normal mice of the same strain. All Tg grafts were rejected within 29 days. In contrast, skin from normal mice that was transplanted to HIV-1-Tg recipients remained viable for > 67 days. Histologic e
Incidence of venereal warts in human immunodeficiency virus-infected and uninfected women.: J Infect Dis. 1995 Jul;172(1):235-8. Unique Identifier : AIDSLINE MED/95318531; Chirgwin KD; Feldman J; Augenbraun M; Landesman S; Minkoff H; Department of Medicine, State University of New York Health; Science Center at Brooklyn 11203, USA.; A cohort of human immunodeficiency virus (HIV)-infected (n = 253) and uninfected (n = 658) women was prospectively studied to assess the relationship between venereal warts and HIV status, adjusting for self-reported and biologic measures of sexual risk behavior. Participants were assessed every 6 months for venereal
Empirically treated Pneumocystis carinii pneumonia in Los Angeles, Chicago, and Miami: 1987-1990.: J Infect Dis. 1995 Jul;172(1):312-5. Unique Identifier : AIDSLINE MED/95318553; Bennett CL; Horner RD; Weinstein RA; Kessler HA; Dickinson GM; Pitrak DL; Gilman SC; George WL; Cohn SE; Simberkoff MS; et al; Dept. of Medicine, Lakeside VA Medical Center, Chicago, IL 60611,; USA.; Many patients infected with the human immunodeficiency virus (HIV) with symptoms suggestive of pneumonia are treated empirically for Pneumocystis carinii pneumonia (PCP), although other bacterial infections (e.g., tuberculosis) and pulmonary Kaposi s sarcoma may cause identical symptoms. Empiric treatment for PCP may
Leishmania-human immunodeficiency virus coinfection in the Mediterranean basin: isoenzymatic characterization of 100 isolates of the Leishmania infantum complex.: J Infect Dis. 1995 Jul;172(1):323-6. Unique Identifier : AIDSLINE MED/95318556; Pratlong F; Dedet JP; Marty P; Portus M; Deniau M; Dereure J; Abranches P; Reynes J; Martini A; Lefebvre M; et al; Laboratoire d'Ecologie Medicale et Pathologie Parasitaire,; Faculte de Medecine, Centre Hospitalo-Universitaire,; Montpellier, France.; Isoenzymatic characterization was done on 100 isolates obtained from visceral leishmaniasis (VL) patients coinfected with human immunodeficiency virus (HIV); isolates had been received between 1986 and 1993 at the International Leishmania Cryobank and Identification Centre in Montpellier,
Seroprevalence of human T cell lymphotropic virus type II infection, with or without human immunodeficiency virus type 1 coinfection, among US intravenous drug users.: J Infect Dis. 1995 Jul;172(1):51-8. Unique Identifier : AIDSLINE MED/95318559; Briggs NC; Battjes RJ; Cantor KP; Blattner WA; Yellin FM; Wilson S; Ritz AL; Weiss SH; Goedert JJ; National Cancer Institute, National Institute on Drug Abuse,; National Institutes of Health, Bethesda, Maryland, USA.; Seroprevalence of human T lymphotropic virus (HTLV) and human immunodeficiency virus type 1 (HIV-1) was determined among 7841 intravenous drug users (IVDUs) from drug treatment centers in Baltimore, Chicago, Los Angeles, New Jersey (Asbury Park and Trenton), New York City (Brooklyn and Harlem), Philadelphia, and San A
Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus.: J Infect Dis. 1995 Jul;172(1):59-69. Unique Identifier : AIDSLINE MED/95318560; Rausch DM; Heyes MP; Murray EA; Eiden LE; Section on Molecular Neuroscience, National Institute of Mental; Health, National Institutes of Health, Bethesda, MD 20892, USA.; To assess the potential therapeutic effects of zidovudine, rhesus macaques were inoculated with simian immunodeficiency virus (SIV) strain SMM/B670 at birth and infused either continuously or intermittently with zidovudine for 6-7 months. Zidovudine did not prevent infection but did significantly increase survival tim
In vitro T cell function, delayed-type hypersensitivity skin testing, and CD4+ T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus.: J Infect Dis. 1995 Jul;172(1):79-87. Unique Identifier : AIDSLINE MED/95318562; Dolan MJ; Clerici M; Blatt SP; Hendrix CW; Melcher GP; Boswell RN; Freeman TM; Ward W; Hensley R; Shearer GM; Department of Infectious Diseases, Wilford Hall Medical Center,; Lackland Air Force Base, TX 78236-5300, USA.; Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens
The predictive value of T cell function in vitro and pre-AIDS zidovudine use for survival after AIDS diagnosis in a cohort of homosexual men in Amsterdam.: J Infect Dis. 1995 Jul;172(1):97-104. Unique Identifier : AIDSLINE MED/95318564; Bindels PJ; Krol A; Roos M; Veenstra J; van den Hoek JA; Miedema F; Coutinho RA; Department of Public Health, Amsterdam, Netherlands.; The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis,
Bleeding after tonsillectomy in severe von Willebrand's disease.: J Laryngol Otol. 1995 May;109(5):437-9. Unique Identifier : AIDSLINE MED/95318626; Alusi GH; Grant WE; Lee CA; Pasi KJ; Stearns MP; Department of Otolaryngology, Head and Neck Surgery, Royal Free; Hospital, School of Medicine, London.; A case is reported of a HIV-positive patient with severe von Willebrand s disease describing the bleeding complications during and after tonsillectomy. This patient underwent surgery for asymmetrical tonsillar hypertrophy. The tonsils were spontaneously haemorrhaging and there therefore was a suspicion of neoplasia. D
Estimating the sexual mixing patterns in the general population from those in people acquiring gonorrhoea infection: theoretical foundation and empirical findings.: J Epidemiol Community Health. 1995 Apr;49(2):205-13. Unique Identifier : AIDSLINE MED/95318677; Renton A; Whitaker L; Ison C; Wadsworth J; Harris JR; Academic Department of Public Health, St Mary's Hospital, London.; STUDY OBJECTIVES--To describe mathematically the relationship between patterns of sexual mixing in the general population and those of people with gonorrhoea infection, and hence to estimate the sexual mixing matrix for the general population. DESIGN--Integration of data describing sexual behaviour in the general popu
Selection of skin test antigens to evaluate PPD anergy.: J Fam Pract. 1995 Jul;41(1):59-64. Unique Identifier : AIDSLINE MED/95318692; Wright PW; Crutcher JE; Holiday DB; Department of Family Practice, University of Texas Health Center; at Tyler 75710, USA.; BACKGROUND. A purified protein derivative (PPD) tuberculin skin test may be nonreactive because of cutaneous anergy, technical problems with the test, or absence of tuberculosis infection. This study investigated the sensitivity and specificity of five test agents in measuring cutaneous anergy when the PPD test is non
Psychiatric morbidity associated with acquired immune deficiency syndrome-related grief resolution.: J Nerv Ment Dis. 1995 Jun;183(6):384-9. Unique Identifier : AIDSLINE MED/95318713; Summers J; Zisook S; Atkinson JH; Sciolla A; Whitehall W; Brown S; Patterson T; Grant I; Department of Psychiatry, University of California, San Diego; 92103, USA.; This study examined acquired immune deficiency syndrome (AIDS)-related grief resolution and psychiatric morbidity in 286 human immunodeficiency virus (HIV)-positive and HIV-negative gay men examined between 1989 and 1993 in San Diego, CA. Psychiatric morbidity, mood ratings, and bereavement assessments were obtained u
A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases.: J Neurol. 1995 Mar;242(4):239-42. Unique Identifier : AIDSLINE MED/95318750; Puccioni-Sohler M; Rieckmann P; Kitze B; Lange P; Albrecht M; Felgenhauer K; Klinik und Poliklinik fur Neurologie, Georg-August-Universitat,; Gottingen, Germany.; Paired samples of cerebrospinal fluid (CSF) and serum from 17 patients with human T-cell lymphotrophic virus I (HTLV-I)-associated myelopathy, 5 patients with multiple sclerosis and 11 controls with non-inflammatory disorders (migraine, idiopathic epilepsy and myelopathy of unknown aetiology) were examined by enzyme-l
Acute necrotizing measles encephalitis in a child with AIDS [letter]: J Neurol. 1995 Mar;242(4):249-51. Unique Identifier : AIDSLINE MED/95318752; Lacroix C; Blanche S; Dussaix E; Tardieu M
Cancrum oris in an HIV-positive patient.: J Oral Maxillofac Surg. 1995 Jul;53(7):851-5. Unique Identifier : AIDSLINE MED/95318805; Barrios TJ; Aria AA; Brahney C; Department of OMFS, Jersey City Medical Center, NJ 07304, USA.
Informal caregivers of persons with AIDS [published erratum appears in J Palliat Care 1995 Autumn;11(3):53]: J Palliat Care. 1995 Summer;11(2):10-8. Unique Identifier : AIDSLINE MED/95318808; Clipp EC; Adinolfi AJ; Forrest L; Bennett CL; Department of Medicine, Veterans Administration, Durham, North; Carolina, USA.
Is there nothing between us? [editorial]: J Palliat Care. 1995 Summer;11(2):3-4. Unique Identifier : AIDSLINE MED/95318812; Roy DJ
AIDS grief: out of the closet and into the boardrooms--the bereaved caregivers.: J Palliat Care. 1995 Summer;11(2):34-7. Unique Identifier : AIDSLINE MED/95318814; Perreault Y; AIDS Bereavement Project of Ontario, Toronto, Canada.
Euthanasia and HIV disease: how can physicians respond?: J Palliat Care. 1995 Summer;11(2):38-41. Unique Identifier : AIDSLINE MED/95318815; Voigt RF; St. Paul's Hospital, Vancouver, British Columbia, Canada.; By accepting the role of caregiver, the physician can do much to decrease the fear surrounding death. By providing an opportunity for a patient to discuss his ideas and feelings about his own death, physicians can better prepare their patients and themselves for the inevitable. None of us can reverse the dying process
Only connect--some thoughts towards the spiritual care of HIV disease.: J Palliat Care. 1995 Summer;11(2):58-60. Unique Identifier : AIDSLINE MED/95318822; Gray N; St. Paul's Anglican Church, Vancouver, British Columbia, Canada.
The new congregation: reflections by an AIDS hospice chaplain.: J Palliat Care. 1995 Summer;11(2):61-3. Unique Identifier : AIDSLINE MED/95318823; Driscoll F; Hospice of San Francisco, California, USA.
Tuberculosis and migration. The Mitchell Lecture 1994 [see comments]: J R Coll Physicians Lond. 1995 Mar-Apr;29(2):113-8. Unique Identifier : AIDSLINE MED/95318893; Davies PD; Cardiothoracic Centre, Liverpool.
Tuberculosis, HIV, hormones and children [editorial; comment]: J R Coll Physicians Lond. 1995 Mar-Apr;29(2):86-8. Unique Identifier : AIDSLINE MED/95318907; Wilkinson RJ; Pasvol G
Childhood tuberculosis and infection with the human immunodeficiency virus [see comments]: J R Coll Physicians Lond. 1995 Mar-Apr;29(2):92-5. Unique Identifier : AIDSLINE MED/95318909; Chintu C; Zumla A; Department of Paediatrics and Child Health, University of Zambia,; School of Medicine, Lusaka.; TB in HIV-infected individuals is a major cause of morbidity and mortality in developing countries and poses enormous problems to the health services. Despite the availability of curative therapy, the incidence of TB in children and adults is increasing at an alarming rate and poses a grave threat to TB control progra
Alcohol use and contraception in first sexual experiences.: J Behav Med. 1995 Feb;18(1):81-95. Unique Identifier : AIDSLINE MED/95318975; Leigh BC; Schafer J; Temple MT; Alcohol Research Group, Berkeley, California 94709, USA.; Recent research has suggested that the use of alcohol or drugs in conjunction with sexual intercourse is associated with nonuse of contraception, particularly in first intercourse experiences. This paper reports findings from a nationally representative sample of adolescents and young adults aged 18-30 who were asked
An assessment of Ryan White Title IIIb HIV early intervention programs in Region VI of the United States Public Health Service.: J Natl Med Assoc. 1995 Jun;87(6):436-40. Unique Identifier : AIDSLINE MED/95318989; Rawlings MK; Stevens RL; Community-Oriented Primary Care Program of Parkland Memorial; Hospital, Dallas, Texas, USA.; A survey was conducted of 15 early intervention programs in Region VI of the United States Public Health Service (USPHS) to determine when human immunodeficiency virus (HIV)-infected clients assessed care. Data were collected from 672 HIV-infected patients who received medical care bet
Transient severe myocardial ischemia during septic shock in a young woman with AIDS.: J Natl Med Assoc. 1995 Jun;87(6):441-2. Unique Identifier : AIDSLINE MED/95318990; Raggi P; Capo W; Sacchi TJ; Division of Cardiology, Long Island College Hospital, Brooklyn,; New York, USA.; A 29-year-old woman with acquired immunodeficiency syndrome (AIDS) was admitted to the intensive care unit with a diagnosis of septic shock. During intensive hemodynamic support with intravenous dopamine, she developed electrocardiographic ischemic changes compatible with an acute injury pattern. The pattern disappear
The cost-effectiveness of voluntary counseling and testing of hospital patients for HIV [letter; comment]: JAMA. 1995 Jul 12;274(2):129; discussion 130. Unique Identifier : AIDSLINE MED/95319022; Mundy LM; Quinn TC
The cost-effectiveness of voluntary counseling and testing of hospital patients for HIV [letter; comment]: JAMA. 1995 Jul 12;274(2):129-30. Unique Identifier : AIDSLINE MED/95319023; Weber JT; Janssen RS; George JR; Ward JW
Risk factors for tuberculosis in HIV-infected persons. A prospective cohort study. The Gruppo Italiano di Studio Tubercolosi e AIDS (GISTA).: JAMA. 1995 Jul 12;274(2):143-8. Unique Identifier : AIDSLINE MED/95319026; Antonucci G; Girardi E; Raviglione MC; Ippolito G; Centro di Riferimento AIDS, Ospedale L. Spallanzani, Rome, Italy.; OBJECTIVE--To analyze how demographic, clinical, and laboratory characteristics influence the risk of tuberculosis in human immunodeficiency virus (HIV)-infected individuals; to examine the incidence of tuberculosis associated with change in skin test responsiveness in HIV-infected, tuberculin-negative, nonanergic ind
The expression of adhesion molecules, including CD11a and CD11b, on the human T lymphocyte surface membrane in patients with bronchial asthma.: Kurume Med J. 1995;42(1):21-32. Unique Identifier : AIDSLINE MED/95319116; Sumida S; Department of Medicine, Kurume University School of Medicine,; Japan.; The beta-2 integrin consists of lymphocyte function-antigen-1 (LFA-1, CD11a/CD18) which binds to the major ligand intracellular adhesion molecules 1 and 2 (ICAM-1 and ICAM-2), Mac-1 (CD11b/CD18, ligand iC3b) and p150,95 (CD11c/CD18, ligand iC3b). These molecules function not only as adhesion molecules but as signal tr
Access to medical care and health-related quality of life for low-income persons with symptomatic human immunodeficiency virus.: Med Care. 1995 Jul;33(7):739-54. Unique Identifier : AIDSLINE MED/95319247; Cunningham WE; Hays RD; Williams KW; Beck KC; Dixon WJ; Shapiro MF; Department of Medicine, School of Medicine, University of; California, Los Angeles, USA.; Despite growing interest in the accessibility of medical care and health-related quality of life for persons infected with human immunodeficiency virus, an association between these variables has not been documented. The authors conducted a cross-sectional study of access to care and its association with health-relate
Sunlight induced progression of AIDS.: Med Hypotheses. 1995 Feb;44(2):119-23. Unique Identifier : AIDSLINE MED/95319349; Vincek V; Department of Microbiology and Immunology, University of Miami; School of Medicine, FL 33101, USA.; Ultraviolet B (UVB) radiation in sunlight damages the cutaneous immune system of individuals primarily by converting trans-urocanic acid (UCA) to its cis isoform which in turn instigates excessive local, and eventually systemic, levels of tumor necrosis factor-alpha (TNF alpha). UVB radiation and TNF alpha have been f
Reversal of ferritin-mediated immunosuppression by levamisole: a rationale for its application to management of the acquired immune deficiency syndrome (AIDS).: Med Hypotheses. 1995 Feb;44(2):85-8. Unique Identifier : AIDSLINE MED/95319356; Wigginton JM; Ferritin is a complex polypeptide which functions primarily as an iron-storage protein. Ferritin may also play a role in the modulation of immune function. It is known to suppress several global measures of the immune response. Specifically, ferritin may mask and/or down-regulate expression of cell surface molecules i
Mother-to-child transmission of the human immunodeficiency virus.: N Engl J Med. 1995 Aug 3;333(5):298-302. Unique Identifier : AIDSLINE MED/95319444; Peckham C; Gibb D; Institute of Child Health, London, United Kingdom.
Clearance of HIV in an infant [letter; comment]: N Engl J Med. 1995 Aug 3;333(5):319; discussion 320. Unique Identifier : AIDSLINE MED/95319451; Krivine A; Lebon P
Pneumocystis in infants and children [letter; comment]: N Engl J Med. 1995 Aug 3;333(5):320-1. Unique Identifier : AIDSLINE MED/95319453; Hughes WT
Hypogammaglobulinemia in HIV-infected infants [letter; comment]: N Engl J Med. 1995 Aug 3;333(5):321-2. Unique Identifier : AIDSLINE MED/95319454; Love JT Jr; Shearer WT
And says blood claims are 'simplistic' [news]: Nature. 1995 Jul 6;376(6535):5. Unique Identifier : AIDSLINE MED/95319532; Butler D
Trans-species transplants raise virus fears [news] [see comments]: Nature. 1995 Jul 6;376(6535):8. Unique Identifier : AIDSLINE MED/95319540; Lehrman S
Maternal-infant transmission of HIV infection: use of zidovudine [news]: Nurse Pract. 1995 Apr;20(4):70-2. Unique Identifier : AIDSLINE MED/95319638; Klaus BD
[Could tuberculosis again be an endemic disease in Hungary? (Model study 1968-1993)]: Orv Hetil. 1995 Jun 18;136(25):1329-32. Unique Identifier : AIDSLINE MED/95319700; Abraham E; Karacsonyi L; Dinya E; Fovarosi Bajcsy-Zsilinszky Korhaz-Rendelointezet, Budapest.; The aim of this examination started in an industrial district of Budapest with 100,000 inhabitants in 1968, was the determination of risk groups of pulmonary tuberculosis and the organisation of X-ray screening. The initial decrease in the incidence of pulmonary tuberculosis stopped (between 1981 and 1993) and, a mini
A pediatrician's view. Building strong adolescents [editorial]: Pediatr Ann. 1995 Apr;24(4):181-2. Unique Identifier : AIDSLINE MED/95319755; Altemeier WA 3rd
Imaging the gastrointestinal tract of children with AIDS.: Pediatr Radiol. 1995;25(2):94-6. Unique Identifier : AIDSLINE MED/95319783; Haller JO; Department of Radiology, State University of New York, Health; Science Center at Brooklyn (Downstate Medical Center) 11203, USA.
Growth-promoting actions of parathyroid hormone, adrenocorticotrophic hormone, and thyroid-stimulating hormone: in vitro studies in normal and pygmy T-lymphoblast cell lines.: Pediatr Res. 1995 Apr;37(4 Pt 1):507-11. Unique Identifier : AIDSLINE MED/95319805; Geffner ME; Bersch N; Cortez AB; Bailey RC; Golde DW; Department of Pediatrics, University of California at Los Angeles; 90024, USA.; We used an in vitro T-lymphoblast clonal proliferation assay to quantify human IGF-I (hIGF-I)-, human PTH (hPTH)-, human ACTH (hACTH)-, and human TSH (hTSH)-stimulated growth of human T-cell leukemia virus-II-transformed T-lymphoblast cell lines from normal individuals and to elucidate the role of IGF-I as the mediato
Limitation of a STOP-AIDS article [letter; comment]: Pediatrics. 1995 Jul;96(1 Pt 1):167. Unique Identifier : AIDSLINE MED/95319821; Tankersley MS
Adolescents' preferences regarding human immunodeficiency virus (HIV)-related physician counseling and HIV testing.: Pediatrics. 1995 Jul;96(1 Pt 1):52-8. Unique Identifier : AIDSLINE MED/95319835; Rawitscher LA; Saitz R; Friedman LS; New England Deaconess Hospital, Harvard Medical School, Boston,; MA, USA.; OBJECTIVE. To assess adolescents preferences regarding human immunodeficiency virus (HIV)-related physician counseling and HIV testing. DESIGN. Anonymous, self-report survey. SETTING. Metropolitan Boston public schools. PARTICIPANTS. Students in 9th and 12th grade from 10 schools. RESULTS. Of the 845 students (99%) w
True presence with families living with HIV disease.: NLN Publ. 1994 Dec;(15-2670):115-33. Unique Identifier : AIDSLINE MED/95319889; Cody WK
The lived experience of grieving, for families living with AIDS.: NLN Publ. 1994 Dec;(15-2670):197-242. Unique Identifier : AIDSLINE MED/95319893; Cody WK
Why can't cytotoxic T cells handle HIV? [comment]: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5765-7. Unique Identifier : AIDSLINE MED/95320155; Bevan MJ; Braciale TJ; Howard Hughes Medical Institute, University of Washington,; Seattle 98195-7370, USA.
Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5773-7. Unique Identifier : AIDSLINE GENBANK/U26673; Moss PA; Rowland-Jones SL; Frodsham PM; McAdam S; Giangrande P; McMichael AJ; Bell JI; Institute of Molecular Medicine, John Radcliffe Hospital,; Headington, Oxford, United Kingdom.; Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTLs) are thought to play a major role in the immune response to HIV infection. The HIV-specific CTL response is much stronger than previously documented in an infectious disease, yet estimates of CTL frequency derived from limiting-dilution analysis
Decreased human immunodeficiency virus type 1 plasma viremia during antiretroviral therapy reflects downregulation of viral replication in lymphoid tissue.: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6017-21. Unique Identifier : AIDSLINE MED/95320206; Cohen OJ; Pantaleo G; Holodniy M; Schnittman S; Niu M; Graziosi C; Pavlakis GN; Lalezari J; Bartlett JA; Steigbigel RT; et al; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892, USA.; Although several immunologic and virologic markers measured in peripheral blood are useful for predicting accelerated progression of human immunodeficiency virus (HIV) disease, their validity for evaluating the response to antiretroviral therapy and their ability to accurately reflect changes in lymphoid organs remain
The bend in RNA created by the trans-activation response element bulge of human immunodeficiency virus is straightened by arginine and by Tat-derived peptide.: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6052-6. Unique Identifier : AIDSLINE MED/95320213; Zacharias M; Hagerman PJ; Department of Biochemistry, Biophysics, and Genetics, University; of Colorado Health Sciences Center, Denver 80262, USA.; The trans-activation response element (TAR) found near the 5 end of the viral RNA of the human immunodeficiency virus contains a 3-nt bulge that is recognized by the virally encoded trans-activator protein (Tat), an important mediator of transcriptional activation. Insertion of the TAR bulge into double-stranded RNA
Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues.: Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6057-61. Unique Identifier : AIDSLINE MED/95320214; Jenkins TM; Hickman AB; Dyda F; Ghirlando R; Davies DR; Craigie R; Laboratory of Molecular Biology, National Institute of Diabetes; and Digestive and Kidney Diseases, Bethesda, MD 20892-0560, USA.; The integrase protein of human immunodeficiency virus type 1 is necessary for the stable integration of the viral genome into host DNA. Integrase catalyzes the 3 processing of the linear viral DNA and the subsequent DNA strand transfer reaction that inserts the viral DNA ends into host DNA. Although full-length integ
Practice of drug abuse among inmates of a drug rehabilitation centre in Hong Kong.: Public Health. 1995 May;109(3):201-5. Unique Identifier : AIDSLINE MED/95320271; Lo YC; Lee SS; Hollinrake JB; Department of Health, Hong Kong Government.; Sharing of contaminated injection equipment accounts for the rapid spread of the human immunodeficiency virus (HIV) among injecting drug users (IDUs). The profile of drug addiction practice among inmates of the Shek Kwu Chau Drug Rehabilitation Centre in
[Anemia in AIDS: the problem to avoid. Human recombinant erythropoietin in the treatment of HIV positive patients]: Przegl Epidemiol. 1994;48(4):441-7. Unique Identifier : AIDSLINE MED/95320321; Karwacki M; Ochocka M; Kubiak W; Klinika Hematologii i Chorob Rozrostowych Dzieci AM w Warszawie.; The most common hematological abnormality associated with HIV infection is anaemia. The aetiology is multifactorial and may include the HIV virus itself; the anaemia of chronic diseases (ACD); infection with other viruses, mycobacteria and fungi; medications, especially zidovudine; and even B12 deficiency. Erythropoie
[Microsporidiosis: a new protozoan disease in persons infected with human immunodeficiency virus (HIV)]: Przegl Epidemiol. 1994;48(4):449-53. Unique Identifier : AIDSLINE MED/95320322; Rogowska-Szadkowska D; Kramarz P; Zaklad Medycyny Rodzinnej Akademii Medycznej w Bialymstoku.; The list of infections, threatening patients with impaired immunological system, especially infected with HIV, prolongs systematically. Since early eighties many authors pay attention to little known type of protozoan: Microspora. More and more often new microsporidia species are described as a cause of disease, espec
Interleukin-8 and eicosanoid production in the lung during moderate to severe Pneumocystis carinii pneumonia in AIDS: a role of interleukin-8 in the pathogenesis of P. carinii pneumonia.: Respir Med. 1995 Apr;89(4):285-90. Unique Identifier : AIDSLINE MED/95320408; Benfield TL; van Steenwijk R; Nielsen TL; Dichter JR; Lipschik GY; Jensen BN; Junge J; Shelhamer JH; Lundgren JD; Department of Infectious Diseases, Hvidovre Hospital,; Righospitalet, University of Copenhagen, Denmark.; Pneumocystis carinii pneumonia (PCP) may cause severe respiratory distress. This is believed to be partly caused by the accumulation of neutrophils in the lung. Interleukin-8 (IL-8) and leukotriene B4 (LTB4) are potent neutrophil chemo-attractants and activators. Eicosanoids [i.e. prostaglandins (PG) and leukotrienes
New perspectives in experimental and clinical research for cutaneous T cell lymphomas.: Recent Results Cancer Res. 1995;139:225-37. Unique Identifier : AIDSLINE MED/95320435; Burg G; Haffner A; Boni R; Dommann S; Dummer R; Department of Dermatology, University of Zurich Medical School,; Switzerland.; Cutaneous T cell lymphomas (CTCL) are lymphoproliferative disorders, which can be classified by an adaptation of the Kiel classification. The most common CTCL, Mycosis fungoides (MF) and Sezary syndrome (SS), are monoclonal T helper memory lymphomas. They belong to the group of peripheral T cell lymphomas. However, CT
Perspectives of cytokine treatment in malignant skin tumors.: Recent Results Cancer Res. 1995;139:349-69. Unique Identifier : AIDSLINE MED/95320446; Garbe C; University Department of Dermatology, Medical Center Steglitz,; Free University of Berlin, Germany.; Cytokines have been tested in the treatment of different skin cancers during the last decade, and treatment schedules have been established or proposed for several malignant skin tumors. Preferentially, the interferons and interleukin-2 were found to be effective in treating skin cancers. Interferons alpha and beta ha
Management of human immunodeficiency virus-associated malignancies.: Recent Results Cancer Res. 1995;139:423-32. Unique Identifier : AIDSLINE MED/95320453; Conant MA; University of California Medical Center, San Francisco, USA.; A number of malignancies which have been seen with other immunodeficiency diseases have appeared in patients immunosuppressed by the human immunodeficiency virus (HIV) infection. These include Kaposi s sarcoma, lymphomas, superficially spreading basal cell carcinomas, and squamous cell carcinomas. The fact that Kaposi
[Pulmonary legionellosis disclosing HIV infection in a 75-year-old man (letter)]: Rev Med Interne. 1995;16(5):370-1. Unique Identifier : AIDSLINE MED/95320468; Zenone T; Marti-Flich J; Heyraud JD; Gontier C; Beaulaton A
[Anti HTLV-I antibody titers in seropositive infected individuals]: Rev Med Chil. 1994 Sep;122(9):1004-7. Unique Identifier : AIDSLINE MED/95320472; Galeno H; Ramirez E; Mora J; Ojeda M; Cartier L; Centro Nacional de Referencia del SIDA (CNRS), Seccion; Virologia, Instituto de Salud Publica de Chile.; The aim of this study was to determine anti HTLV-I antibody titers in seropositive symptomatic and asymptomatic infected subjects. One hundred seven infected subjects (47 with spastic paraparesis and 60 asymptomatic) were studied. HTLV-I antibodies were determined using indirect immunofluorescence in cells infected wi
Intensive care for patients with AIDS: clinical and ethical issues.: Schweiz Med Wochenschr. 1995 Jun 10;125(23):1119-22. Unique Identifier : AIDSLINE MED/95320542; Wachter RM; Medical Service, San Francisco General Hospital Medical Center,; University of California 94143-0862, USA.; Pneumocystis carinii pneumonia (PCP) remains a common and morbid infection among patients with the acquired immunodeficiency syndrome (AIDS). Most patients who die of PCP do so because of respiratory failure. The survival after intubation and mechanical ventilation for PCP and respiratory failure has gone through thre
[Pneumocystis carinii pneumonia in infants with vertically acquired HIV infection in Switzerland]: Schweiz Med Wochenschr. 1995 Jun 10;125(23):1162-7. Unique Identifier : AIDSLINE MED/95320548; Berger C; Albisetti M; Fanconi S; Rudin C; Cheseaux JJ; Micallef J; Kind C; Nadal D; Universitats-Kinderklinik Zurich.; OBJECTIVE: Review of incidence, clinical picture, therapy, and outcome of Pneumocystis carinii pneumonia (PCP) in infants with vertically-acquired HIV infection in Switzerland . METHODS: Inquiry among members of the Swiss Pediatrics AIDS Group, review of the data base of the Sw
Clinical brain radionuclide imaging studies.: Semin Nucl Med. 1995 Apr;25(2):111-43. Unique Identifier : AIDSLINE MED/95320562; Messa C; Fazio F; Costa DC; Ell PJ; INB-CNR, University of Milan, S. Raffaele Institute, Italy.; A recent survey of the knowledge and practice of both positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) of the brain among referring physicians in Europe (neurologists and psychiatrists) showed a disquieting lack of knowledge of the potential of these methodologies in the invest
Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes.: Semin Liver Dis. 1995 Feb;15(1):41-63. Unique Identifier : AIDSLINE MED/95320599; Bukh J; Miller RH; Purcell RH; Hepatitis Viruses Section, National Institutes of Health,; Bethesda, Maryland 20892-0740, USA.; Worldwide, HCV is a major etiologic agent of chronic hepatitis that may lead to the development of liver cirrhosis and hepatocellular carcinoma. Thus, significant morbidity and mortality is caused by HCV infection and effective control measures against the spread of this virus are needed. Originally, the extent of gen
In search of a contemporary theory for understanding mortality change [letter; comment]: Soc Sci Med. 1995 Apr;40(8):1165. Unique Identifier : AIDSLINE MED/95320627; Bulterys M
Skin necrosis indicating antiphospholipid syndrome in patient with AIDS.: South Med J. 1995 Jul;88(7):786-8. Unique Identifier : AIDSLINE MED/95320649; Soweid AM; Hajjar RR; Hewan-Lowe KO; Gonzalez EB; Department of Internal Medicine, Emory University School of; Medicine, Atlanta, GA, USA.; Although antiphospholipid antibodies have been detected in patients with human immunodeficiency virus (HIV) disease, the clinical manifestations of the antiphospholipid syndrome are extremely rare. We describe a woman with acquired immunodeficiency syndrome (AIDS) and elevated antiphospholipid antibodies who developed
HIV testing and informed consent [letter; comment]: S Afr Med J. 1995 Feb;85(2):114. Unique Identifier : AIDSLINE MED/95320679; Lawson HH
Proposals for the feasible management of tuberculosis in HIV-seropositive South Africans [editorial]: S Afr Med J. 1995 Feb;85(2):68-71. Unique Identifier : AIDSLINE MED/95320694; Lee T; Masobe P; Schneider H
Isoniazid prophylactic therapy for tuberculosis in HIV-seropositive patients--a least-cost analysis.: S Afr Med J. 1995 Feb;85(2):75-81. Unique Identifier : AIDSLINE MED/95320698; Masobe P; Lee T; Price M; Department of Community Health, University of the Witwatersrand,; Johannesburg.; The expected upsurge in the number of new cases of tuberculosis resulting from the HIV/AIDS epidemic prompted an examination of the feasibility of prevention strategies to limit the increase in clinical tuberculosis. A computer spreadsheet model was developed to estimate the costs and benefits that would result from i
Recovery of Pseudomonas aeruginosa in respiratory specimens from HIV positive patients being evaluated for Pneumocystis carinii pneumonia.: Thorax. 1995 May;50(5):548-50. Unique Identifier : AIDSLINE MED/95320833; Doyle RL; Doherty JJ; Zimmerman LH; Cardiovascular Research Institute, University of California at; San Francisco, USA.; BACKGROUND--Despite the immune suppression, frequent hospital admissions, and many intercurrent illnesses associated with HIV infection, Pseudomonas aeruginosa has been cited relatively infrequently as a respiratory pathogen in HIV positive patients. METHODS--The microbiological isolates, medical records, radiographic
AIDS and the lung: update 1995. 4. Role of the human immunodeficiency virus within the lung.: Thorax. 1995 May;50(5):567-76. Unique Identifier : AIDSLINE MED/95320839; Clarke JR; Robinson DS; Coker RJ; Miller RF; Mitchell DM; Department of Virology, St Mary's Hospital, London.
Transactivation of human T-cell leukemia virus type 1 by herpes simplex virus type 1.: Virus Genes. 1995 Feb;9(3):269-76. Unique Identifier : AIDSLINE MED/95320972; Israel S; Mendelovitz M; Honigman A; Department of Molecular Genetics, Hebrew University-Hadassah; Medical School, Jerusalem, Israel.; HTLV-1 transcription depends upon activation by the HTLV-1 tax gene product. In addition, various substances and cellular transcription factors are also known to activate the HTLV-1 long terminal repeat (LTR)-mediated transcription in the absence of Tax. In this work we demonstrate that infection of either Jurkat or 2
Sequence analysis of HIV-1 vif gene in Spanish isolates.: Virus Genes. 1995 Feb;9(3):283-8. Unique Identifier : AIDSLINE MED/95320974; Olivares I; Menendez-Arias L; Rodriguez-Bernabe A; Martin MJ; Dopazo J; Lopez-Galindez C; Centro Nacional de Biologia Celular y Retrovirus, Instituto; Carlos III, Majadahonda, Madrid, Spain.; We have determined the nucleotide sequence of the HIV-1 vif gene in viruses obtained from symptomatic patients of distinct risk groups in Madrid. The genetic diversity among the isolates was estimated in 4.6% (+/- 1.4 standard deviation), a similar value to that obtained for the gag gene 3.9% (+/- 0.8 standard deviati
Seroprevalence of bovine immunodeficiency-virus (BIV) antibodies in the cattle population in Germany.: Zentralbl Veterinarmed [B]. 1994 Dec;41(10):679-84. Unique Identifier : AIDSLINE MED/95321030; Muluneh A; Institute of Microbiology and Infectious Diseases, Faculty of; Veterinary Medicine, University of Leipzig.; Serum samples from 380 cattle were analysed for the presence of bovine immunodeficiency-virus (BIV) antibodies by focus immunoassay (cell-ELISA) and immunofluorescence assay (IFA). All specimens originated from dairy farms in the eastern part of Germany , which had been randomly co
Pathogenesis of IgA nephropathy [editorial]: Acta Clin Belg. 1995;50(2):71-5. Unique Identifier : AIDSLINE MED/95321046; Davin JC
Effect of qigong training on proportions of T lymphocyte subsets in human peripheral blood.: Am J Chin Med. 1995;23(1):27-36. Unique Identifier : AIDSLINE MED/95321297; Ryu H; Jun CD; Lee BS; Choi BM; Kim HM; Chung HT; Department of Microbiology and Immunology, School of Medicine,; Wonkwang University, Republic of Korea.; The effect of Qigong training on proportions of T lymphocyte subsets was investigated in human peripheral blood. We observed that the ratio of CD4+/CD8+ T lymphocytes was increased as much as 50% in a trainee group who practiced Qigong training more than 5 months compared to a normal healthy group who did not practice
Asymptomatic neurocysticercosis in a patient with AIDS and cryptococcal meningitis.: Am J Med. 1995 Jul;99(1):101-2. Unique Identifier : AIDSLINE MED/95321335; White AC Jr; Dakik H; Diaz P; Baylor College of Medicine, Houston, Texas, USA.
Syphilis and neurosyphilis in a human immunodeficiency virus type-1 seropositive population: evidence for frequent serologic relapse after therapy.: Am J Med. 1995 Jul;99(1):55-63. Unique Identifier : AIDSLINE MED/95321352; Malone JL; Wallace MR; Hendrick BB; LaRocco A Jr; Tonon E; Brodine SK; Bowler WA; Lavin BS; Hawkins RE; Oldfield EC 3rd; Department of Internal Medicine (Infectious Diseases Division),; Naval Medical Center, San Diego, California, USA.; OBJECTIVE: To describe clinical and treatment aspects of syphilis infection among patients seropositive for the human immunodeficiency virus (HIV). PATIENTS AND METHODS: Results of serologic tests for syphilis, CD4+ T-lymphocyte counts, and clinical response to therapy were retrospectively monitored in 100 HIV-infecte
AIDS-associated progressive multifocal leukoencephalopathy revealed by new-onset seizures.: Am J Med. 1995 Jul;99(1):64-8. Unique Identifier : AIDSLINE MED/95321354; Moulignier A; Mikol J; Pialoux G; Fenelon G; Gray F; Thiebaut JB; Service de Neurologie, Hopital Tenon, Paris, France.; PURPOSE: To describe the clinical features of new-onset seizures in HIV-1-infected persons with progressive multifocal leukoencephalopathy (PML), and to discuss potential mechanisms. PATIENTS AND METHODS: Forty-nine consecutive HIV-1-infected patients with PML attended our institutions between January 1988 and Septemb
Universal precautions are not universally practiced by anesthesiologists [letter; comment]: Anesth Analg. 1995 Jul;81(1):205. Unique Identifier : AIDSLINE MED/95321474; Berry AJ; Greene E
Love, sex, and power. Considering women's realities in HIV prevention.: Am Psychol. 1995 Jun;50(6):437-47. Unique Identifier : AIDSLINE MED/95321504; Amaro H; Boston University School of Public Health, Social and Behavioral; Sciences Department, Boston, MA 02118-2389, USA.; The rates of HIV infection and AIDS cases among women in the United States have increased significantly in the last decade. Thanks in large part to the work of advocacy groups and to action by the U.S. Congress, there has been some progress in making HIV/AIDS research and services more
Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group [see comments]: Ann Intern Med. 1995 Aug 1;123(3):175-80. Unique Identifier : AIDSLINE MED/95321510; Podzamczer D; Miro JM; Bolao F; Gatell JM; Cosin J; Sirera G; Domingo P; Laguna F; Santamaria J; Verdejo J; Ciutat Sanitaria de Bellvitge, Hospital Clinic, Barcelona,; Spain.; OBJECTIVE: To evaluate the efficacy of twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent toxoplasmic encephalitis relapse in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Randomized, open, multicenter trial. Patients were randomly assigned to receive sulfadiazine (500 m
Toxoplasmosis in AIDS: keeping the lid on [editorial; comment]: Ann Intern Med. 1995 Aug 1;123(3):230-1. Unique Identifier : AIDSLINE MED/95321518; Kovacs JA
Risks of HIV infection in the health care setting.: Annu Rev Med. 1995;46:203-11. Unique Identifier : AIDSLINE MED/95321671; Fraser VJ; Powderly WG; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110, USA.; Health care workers exposed to blood and body fluids have a low but measurable risk of occupational infection with human immunodeficiency virus (HIV). This risk is related to the prevalence of HIV among patients, the frequency of exposure to infected blood, and the method of exposure. The magnitude of risk is thus dif
The changing face of tuberculosis.: Annu Rev Med. 1995;46:47-55. Unique Identifier : AIDSLINE MED/95321695; Huebner RE; Castro KG; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, Georgia 30333, USA.; Tuberculosis (TB) remains an important public health problem worldwide, resulting in a estimated 8 to 10 million new cases and 2 to 3 million deaths each year. Between 1953 and 1985, the number of TB cases in the US declined by an average of 6% per year. However, since 1985, TB has been increasing in the US. Approxima
The relationship between serum or plasma levels of tumor necrosis factor alpha and neuropsychological functioning in early human immunodeficiency virus infection.: Appl Nurs Res. 1995 May;8(2):88-91. Unique Identifier : AIDSLINE MED/95321742; Swanson B; Cronin-Stubbs D; Zeller JM; Bieliauskas LA; Kessler HA; Division of Epidemiology and Biostatistics, School of Public; Health, University of Illinois at Chicago, USA.
Reversible acute renal failure due to sulfonamide-induced lithiasis in an AIDS patient.: Arch Esp Urol. 1995 May;48(4):418-9. Unique Identifier : AIDSLINE MED/95321782; Farina LA; Palou Redorta J; Chechile Toniolo G; Urology Department, Fundacion Puigvert, Barcelona, Spain.; OBJECTIVE: Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDS patient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emer
Infection control for peritoneal dialysis patients with HIV.: ANNA J. 1995 Feb;22(1):56, 62. Unique Identifier : AIDSLINE MED/95321791; Baldasseroni A
Viral-specific humoral immune responses following transfusion-related transmission of human T cell lymphotropic virus type-I infection.: Viral Immunol. 1994;7(3):113-20. Unique Identifier : AIDSLINE MED/95322006; Manns A; Wilks RJ; Hanchard B; Morgan OS; Rudolph DL; Lal RB; Viral Epidemiology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892, USA.; The immunoglobulin (Ig) isotypes of antibodies to specific proteins of the human T cell lymphotropic virus type I (HTLV-I) were determined by Western blot analysis of serial specimens from six individuals who experienced HTLV-I seroconversion following blood transfusion; five remained asymptomatic carriers, while one
Peripheral T cell receptor repertoire among CD4+ and CD8+ subsets during acute infectious mononucleosis.: Viral Immunol. 1994;7(3):151-3. Unique Identifier : AIDSLINE MED/95322010; Slobod KS; Leggiadro RJ; Presbury G; Smith FS; Hurwitz JL; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee, USA.
Human neonatal thymic organ culture: an ex vivo model of thymocyte ontogeny and HIV-1 infection.: Pathobiology. 1994;62(5-6):245-51. Unique Identifier : AIDSLINE MED/95322016; Rosenzweig M; Bunting EM; Damico RL; Clark DP; Gaulton GN; Department of Pathology and Laboratory Medicine, School of; Medicine, University of Pennsylvania, Philadelphia 19104, USA.; An intact thymic microenvironment is required for the normal maturation and selection of thymocytes. This process is directed by the interaction of thymocyte progenitors with molecules on the surface of thymic stromal cells and with cytokines. The precise nature of these events is poorly understood in humans. We have
Advances in antisense efficacy and delivery.: Trends Biotechnol. 1995 Jun;13(6):197-9. Unique Identifier : AIDSLINE MED/95322068; Agrawal S; Akhtar S; Pharmaceutical Sciences Institute, Aston University, Birmingham,; UK.
Developmental and tissue-specific expression of human CD4 in transgenic rabbits.: Mol Reprod Dev. 1995 Apr;40(4):419-28. Unique Identifier : AIDSLINE MED/95322141; Snyder BW; Vitale J; Milos P; Gosselin J; Gillespie F; Ebert K; Hague BF; Kindt TJ; Wadsworth S; Leibowitz P; Exemplar Corporation, Bay Colony Corporate Center, Waltham,; Massachusetts, USA.; A major obstacle to understanding AIDS is the lack of a suitable small animal model for studying HIV-1 infection and the subsequent development of AIDS, and for testing diagnostic, therapeutic, and preventive modalities. Our goal is to produce a rabbit model for the study of AIDS. Here we report on the generation of t
Interleukin-4 is required for the induction of lung Th2 mucosal immunity.: Am J Respir Cell Mol Biol. 1995 Jul;13(1):54-9. Unique Identifier : AIDSLINE MED/95322177; Coyle AJ; Le Gros G; Bertrand C; Tsuyuki S; Heusser CH; Kopf M; Anderson GP; Department of Asthma and Allergy, Ciba-Geigy Ltd., Basel,; Switzerland.; Aerosol antigen challenge of ovalbumin-sensitized mice induced an eosinophilic airway inflammation that was dependent on interleukin (IL)-5 and CD4+, but not CD8+, T lymphocytes. The involvement of the Th2 phenotype of CD4+ T cells was supported by demonstrating that FACS-sorted purified lung T cells from sensitized,
[Analysis of the possibility of transmitting the human immunodeficiency virus when using cartilage grafts]: Acta Otorrinolaringol Esp. 1995 Mar-Apr;46(2):75-81. Unique Identifier : AIDSLINE MED/95322221; Bujia J; Wilmes E; Gurtler L; Departamento de ORL, Ludwig-Maximilians, Universidad de Munich.; Allogenic cartilage represents an important source of tissue for reconstructive surgery in the head and neck. The use of allografts is now being discussed because of the possible transmission of the human immunodeficiency virus (HIV). The purpose of this study was to investigate the susceptibility and permissivity of
[Langerhans cells and human aural cholesteatoma]: Chung Hua Erh Pi Yen Hou Ko Tsa Chih. 1995;30(1):33-6. Unique Identifier : AIDSLINE MED/95322233; Liu L; Li Z; Hu M; First Hospital, Xinjiang Medical Collage.; Enzyme histochemical, immunohistochemical and ultramicroscopic analysis of 20 human aural cholesteatoma matrices revealed the presence of Langerhans cells, T lymphocytes, B lymphocytes and HLA-DR positive cells. There was no significant difference of the numerical density on the area of Langerhans cells between the ch
President's address to the General Dental Council [editorial]: Br Dent J. 1995 Jun 10;178(11):395-7. Unique Identifier : AIDSLINE MED/95322259; Seward M
NMR solution structure of the RNA-binding peptide from human immunodeficiency virus (type 1) Rev.: Biochemistry. 1995 Jul 4;34(26):8242-9. Unique Identifier : AIDSLINE PDB/1RPV; Scanlon MJ; Fairlie DP; Craik DJ; Englebretsen DR; West ML; Centre for Drug Design and Development, University of Queensland,; St Lucia, Australia.; NMR spectroscopy has been used to solve the three-dimensional solution structure of a minimal RNA-binding domain of the Rev protein from the human immunodeficiency virus (type 1), an essential regulatory protein for viral replication. The presence of 10 arginine residues in the 17-residue peptide Rev34-50 caused signi
Correlation of antiviral activity with beta-turn types for V3 synthetic multibranched peptides from HIV-1 gp120.: Biochemistry. 1995 Jul 4;34(26):8294-8. Unique Identifier : AIDSLINE MED/95322380; Mabrouk K; Van Rietschoten J; Rochat H; Loret EP; Laboratoire de Biochimie, CNRS URA 1455, IFR Jean Roche-Faculte; de Medecine Nord, Marseille, France.; SPC3 is a synthetic multibranched peptide containing eight HIV-1 gp120 V3 loop GPGRAF motifs. SPC3 inhibits HIV-1 infection in human lymphocytes and macrophages, while the monomer counterpart of SPC3, i.e., the GPGRAF peptide, has no effect. Circular dichroism (CD) of these molecules in phosphate buffer, pH 7, and in
Properties of base-pairing in the stem region of hairpin antisense oligonucleotides containing 2'-methoxynucleosides.: Biochim Biophys Acta. 1995 Jun 9;1244(2-3):339-44. Unique Identifier : AIDSLINE MED/95322418; Hosono K; Kuwasaki T; Tsukahara S; Takai K; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.; We have designed a new type of antisense oligodeoxyribonucleotide. These oligonucleotides are able to form hairpin loop structures at the 3 -ends. The stability to nuclease degradation was observed by incubation of these hairpin oligonucleotides with snake venom phosphodiesterase, DNA polymerase, and fetal bovine seru
HIV and tuberculosis: noncompliance revisited.: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):11-23. Unique Identifier : AIDSLINE MED/95322606; Anastasio CJ; Beth Israel Medical Center, New York, NY, USA.; Revisiting the stereotype of the noncompliant patient can transcend the frustrating or resentful feelings nurses may experience when caring for patients with HIV and tuberculosis. This reevaluation also can lend itself to developing mutually participative nurse-patient relationships. The author suggests relationship g
Psychological states in HIV disease and the nursing response.: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):25-32. Unique Identifier : AIDSLINE MED/95322607; Grimes RM; Grimes DE; AIDS Regional Education and Training Centers for Texas and; Oklahoma, Houston, USA.; The authors review the four major psychological states of HIV infection as described by Nichols (1985) and adapt these manifestations for use by the nurse in the clinical setting. The states and their likely impacts are described. The diagnostic tools for recognizing the states, assessment questions that help establis
Community-based HIV case management: challenges and opportunities.: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):33-40. Unique Identifier : AIDSLINE MED/95322608; Sowell RL; AID Atlanta, Inc., GA, USA.; Over the past decade, case management has become a popular strategy for the organization and delivery of health service. Yet, in many settings, a lack of clarity exists as to the exact function and process of case management. The author addresses key issues in the debate surrounding case management and provides insigh
Changes in taste associated with intravenous administration of pentamidine (revised) [corrected and republished article originally printed in J Assoc Nurses AIDS Care 1995 Jan-Feb;6(1):43-8]: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):41-6. Unique Identifier : AIDSLINE MED/95322609; Glover J; Dibble S; Miaskowski C; Geibert R; Infusion Center, Kaiser Permanente Medical Group, San Francisco,; CA, USA.; In this pilot study the authors set out to: (a) describe the incidence of taste changes associated with intravenous (i.v.) pentamidine treatment; and (b) determine the factors that are related to making the taste changes better and worse. A convenience sample (N = 18) of adult male outpatients with AIDS participated i
A conversation with Kristine Gebbie: the first national AIDS policy coordinator [interview by Susan Gaskins]: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):47-9. Unique Identifier : AIDSLINE MED/95322610; Gebbie K; Capstone College of Nursing, University of Alabama, Tuscaloosa,; USA.
Seeking a moral center [editorial]: J Assoc Nurses AIDS Care. 1995 Mar-Apr;6(2):9-10. Unique Identifier : AIDSLINE MED/95322611; Kalinoski J
Cutaneous leishmaniasis in AIDS [letter]: Dermatology. 1995;190(3):255-6. Unique Identifier : AIDSLINE MED/95322680; Nicolas M; Gimenez-Arnau A; Camarasa JG
Cytomegalovirus retinitis.: Br J Theatre Nurs. 1995 May;5(2):29. Unique Identifier : AIDSLINE MED/95322724; Cytomegalovirus ( CMV ) is a member of the herpes virus family, which also includes herpes simplex virus types 1 and 2, varicella-zoster virus, and Epstein-Barr virus. CMV is a common viral infection that, in the absence of HIV or other immunocompromising conditio
The inhibitor of calcium activated neutral proteinase is an anti-meiotic agent. The spermicidal and anti-viral action.: Histol Histopathol. 1995 Apr;10(2):271-82. Unique Identifier : AIDSLINE MED/95322734; Logothetou-Rella H; Department of Experimental Physiology, Medical School, University; of Athens, Greece.; In situ cytogenetic morphology and analysis showed that Epstein-Barr Virus (EBV)-infected Raji and EBV-producing P3HR-1 cells divide by meiosis and follow the life cycle of malignant cells in vitro. Meiosis was documented by the presence of condensed chromosomes, o chromosome, nuclear vlimata (NVs), NV invasion, extru
Report from the front lines: interview with Janet Spinner [interview by Ina May Gaskin]: Birth Gaz. 1995 Spring;11(2):14-20. Unique Identifier : AIDSLINE MED/95322854; Spinner J
Characterization of the alloreactivity and anti-leukemia reactivity of cord blood mononuclear cells.: Bone Marrow Transplant. 1995 Mar;15(3):407-19. Unique Identifier : AIDSLINE MED/95322901; Keever CA; Abu-Hajir M; Graf W; McFadden P; Prichard P; O'Brien J; Flomenberg N; Bone Marrow Transplantation Program, Medical College of; Wisconsin, Milwaukee County Medical Complex 53226, USA.; It has been suggested that cord blood T cells may be less able to mediate GVHD than marrow-derived T cells due to their naive status. A decreased potential for GVHD may be advantageous for allogeneic transplant, but this benefit might be counteracted by loss of the GVHD associated graft-versus-leukemia (GVL) effect. T
Assessing the information needs of non-institutionally affiliated AIDS service organizations in Texas.: Bull Med Libr Assoc. 1995 Apr;83(2):240-3. Unique Identifier : AIDSLINE MED/95322929; Huber JT; Machin MS; Active Digital Library, Eskind Biomedical Library, Vanderbilt; University Medical Center, Nashville, Tennessee 37232-8340, USA.
Tuberculosis of the foot as the initial manifestation of acquired immune deficiency syndrome: a report of two cases.: Foot Ankle Int. 1995 Mar;16(3):167-71. Unique Identifier : AIDSLINE MED/95323084; Lonner JH; Sheskier SC; Department of Orthopaedic Surgery, Hospital for Joint Diseases,; Orthopaedic Institute, New York, New York 10003, USA.; Two cases of tuberculosis of the forefoot are presented to highlight a growing threat in our Western communities. Each represents an initial manifestation of occult infection with the human immunodeficiency virus. Delays in diagnosis and treatment existed because of equivocal and nonspecific clinical, radiographic, an
The polymerase chain reaction in the diagnosis and evaluation of pulmonary infections.: Am J Respir Crit Care Med. 1995 Jul;152(1):11-6. Unique Identifier : AIDSLINE MED/95323157; Schluger NW; Rom WN; Bellevue Chest Service, New York University Medical Center, New; York, USA.; One of the most heralded developments in basic science to reach clinical application in recent years has been the polymerase chain reaction (PCR). This technique of DNA amplification, which has already had an enormous effect on the way in which molecular biology research is done (and whose inventor, Kary Mullis, was a
Lymphocyte subsets in bronchoalveolar lavage fluid of children without bronchopulmonary disease.: Am J Respir Crit Care Med. 1995 Jul;152(1):174-8. Unique Identifier : AIDSLINE MED/95323169; Ratjen F; Bredendiek M; Zheng L; Brendel M; Costabel U; Department of Pediatrics, University of Essen, Ruhrlandklinik,; Germany.; Bronchoalveolar lavage (BAL) is increasingly used in the pediatric age group. However, normal values for BAL fluid (BALF) constituents are lacking. As part of an investigation to define reference values in children, we studied lymphocyte surface markers of BALF in 28 children 3 to 16 yr of age without bronchopulmonary
Quantitative culture of HIV-1 from bronchoalveolar lavage cells.: Am J Respir Crit Care Med. 1995 Jul;152(1):254-9. Unique Identifier : AIDSLINE MED/95323182; Pinkston P; Pelletier N; Arena C; Schock J; Garland R; Rose RM; Division of Pulmonary and Critical Care Medicine, New England; Deaconess Hospital, Boston, Massachusetts 02215, USA.; Determination of the infectious virus burden at the organ level is critical for understanding the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection. To evaluate the burden of HIV-1 in the lung, quantitative cultures were performed on bronchoalveolar lavage (BAL) cells from 11 HIV-1 seropositive
Transmission of multidrug-resistant tuberculosis in a large urban setting.: Am J Respir Crit Care Med. 1995 Jul;152(1):355-9. Unique Identifier : AIDSLINE MED/95323196; Friedman CR; Stoeckle MY; Kreiswirth BN; Johnson WD Jr; Manoach SM; Berger J; Sathianathan K; Hafner A; Riley LW; Division of Infectious Diseases, Cornell University Medical; College, New York, NY 10021, USA.; Multidrug resistance has become an increasingly important problem in the control and prevention of tuberculosis in large urban centers. Although several small outbreaks of multidrug-resistant (MDR) tuberculosis in New York City have been reported, the increase in the number of cases is not fully explained by these rec
Vertical transmission of human immunodeficiency virus [editorial]: Br J Hosp Med. 1995 Apr 19-May 2;53(8):365-7. Unique Identifier : AIDSLINE MED/95323246; Stafford M; Smith JR
Failure of preoperative human immunodeficiency virus (HIV) antibody testing to detect HIV positivity.: Br J Hosp Med. 1995 Apr 19-May 2;53(8):408-9. Unique Identifier : AIDSLINE MED/95323254; Lipman MC; Gluck TA; Johnson MA; Department of Thoracic Medicine, Royal Free Hospital, London.
IL-6 induces target cell resistance to HIV-specific cytotoxic lysis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):321-31. Unique Identifier : AIDSLINE MED/95323462; Liu M; Martinez-Maza O; Johnson MT; Fan J; Kishimoto T; Plaeger S; Department of Microbiology and Immunology, UCLA School of; Medicine 90095-1752, USA.; Interleukin-6 (IL-6) is a pleiotropic cytokine with multiple immunomodulatory functions. Although IL-6 enhances cytotoxic effector cell function in vitro, we report the paradoxical effect of IL-6-induced resistance of target cells to lysis by cytotoxic T lymphocytes (CTL). The CTL system employed autologous, Epstein-B
Sodium butyrate stimulation of HIV-1 gene expression: a novel mechanism of induction independent of NF-kappa B.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):332-9. Unique Identifier : AIDSLINE MED/95323463; Laughlin MA; Chang GY; Oakes JW; Gonzalez-Scarano F; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, PA 19107, USA.; Nuclear factor-kappa B (NF-kappa B) has been shown to play a central role in stimulating human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-directed viral gene expression. We have previously described a cell line (TE671/RD) that fails to respond to phorbol myristate acetate (PMA) or tumor necrosis
Expression of nuclear lectin carbohydrate-binding protein 35 in human immunodeficiency virus type 1-infected Molt-3 cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):340-8. Unique Identifier : AIDSLINE MED/95323464; Schroder HC; Ushijima H; Theis C; Seve AP; Hubert J; Muller WE; Institut fur Physiologische Chemie, Abteilung fur Angewandte; Molekularbiologie, Mainz, Germany.; The nuclear carbohydrate-binding protein 35 (CBP35), a beta-galactoside-specific lectin with an M(r) of 35,000, has been identified in nuclear ribonucleoprotein complexes (RNPs) from a variety of mammalian tissues and cells. Here we determined that the expression of CBP35 mRNA greatly increases after infection of Molt
Gynecologic disease in women infected with human immunodeficiency virus [editorial; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):359-60. Unique Identifier : AIDSLINE MED/95323466; Sweet RL
Gynecologic disease in women infected with human immunodeficiency virus type 1 [see comments]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):361-70. Unique Identifier : AIDSLINE MED/95323467; Korn AP; Landers DV; Department of Obstetrics, Gynecology, and Reproductive Sciences,; University of California, USA.; Gynecologic disease is commonly encountered in women infected with the human immunodeficiency virus (HIV). The clinical course of cervical intraepithelial neoplasia, invasive cervical cancer, pelvic inflammatory disease, syphilis, and vaginal candidiasis may be altered by HIV infection and may be refractory to standar
Prenatal care of HIV-infected women: analysis of a large New York State cohort.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):371-8. Unique Identifier : AIDSLINE MED/95323468; Turner BJ; Markson L; Hauck W; Cocroft J; Fanning T; Division of General Internal Medicine, Jefferson Medical College,; Philadelphia, Pennsylvania, USA.; We examined the effect of methadone treatment, duration of Medicaid enrollment during pregnancy, and other maternal characteristics on receipt of prenatal care by 2,254 women infected with human immunodeficiency virus (HIV) delivering a singleton in New York state from 1985 through 1990. Data were obtained from the Ne
Unifying hypothesis for the pathogenesis of HIV-associated dementia complex, vacuolar myelopathy, and sensory neuropathy.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):379-88. Unique Identifier : AIDSLINE MED/95323469; Tyor WR; Wesselingh SL; Griffin JW; McArthur JC; Griffin DE; Department of Neurology, Medical University of South Carolina,; Charleston, USA.; Neurological diseases associated with HIV infection include dementia , vacuolar myelopathy, and sensory neuropathy. Although in vitro studies suggest that other nervous system cell types could harbor HIV, immunohistochemical and in situ hybridization studies have indicated that only
Human herpesvirus-6 and the course of human immunodeficiency virus infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):389-94. Unique Identifier : AIDSLINE MED/95323470; Blazquez MV; Madueno JA; Jurado R; Fernandez-Arcas N; Munoz E; Departamento de Fisiologia e Immunologia, Facultad de Medicina,; Universidad de Cordoba, Spain.; The aim of this study is to investigate the relationship between human herpesvirus type 6 (HHV-6) and cytomegalovirus ( CMV ) infection and progression of AIDS disease. A group of 52 HIV-1-seropositive patients was examined for
Prevalence, incidence, and risks for HIV-1 infection in female sex workers in Miami, Florida.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):395-400. Unique Identifier : AIDSLINE MED/95323471; Onorato IM; Klaskala W; Morgan WM; Withum D; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; Annual cross-sectional prevalence, incidence of new infection, and risks for human immunodeficiency virus type 1 (HIV-1) infection were studied in 607 women convicted of prostitution between October 1987 and December 1990 and tested for HIV under court order. Cross-sectional prevalence was stable for 4 years (23-24% p
Zidovudine for the prevention of vertical HIV transmission: a decision analytic approach.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):401-7. Unique Identifier : AIDSLINE MED/95323472; Rouse DJ; Owen J; Goldenberg RL; Vermund SH; Department of Obstetrics and Gynecology, University of Alabama at; Birmingham, USA.; The purpose of this study was to quantify the benefits of maternal-neonatal zidovudine (ZDV) administration for the prevention of vertical human immunodeficiency virus (HIV) transmission against the potential risks of drug-induced complications in uninfected children. A decision analysis model was created with use of
Diagnosis and screening of HIV/AIDS using clinical criteria in Tanzanian adults.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):408-14. Unique Identifier : AIDSLINE MED/95323473; Miller WC; Thielman NM; Swai N; Cegielski JP; Shao J; Manyenga D; Mlalasi J; Lallinger GJ; Division of Infectious Diseases and International Health, Duke; University Medical Center, Durham, NC 27710, USA.; The clinical utility of the World Health Organization (WHO) clinical case definition (CCD) of acquired immune deficiency syndrome (AIDS) in Africa, several proposed modifications of the WHO CCD, and two proposed screening algorithms for human immunodeficiency virus (HIV) infection were
Four years of natural history of HIV-1 infection in african women: a prospective cohort study in Kigali (Rwanda), 1988-1993.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):415-21. Unique Identifier : AIDSLINE MED/95323474; Leroy V; Msellati P; Lepage P; Batungwanayo J; Hitimana DG; Taelman H; Bogaerts J; Boineau F; Van de Perre P; Simonon A; et al; INSERM U. 330, University of Bordeaux II, France.; Clinical features and mortality due to human immunodeficiency virus type-1 (HIV-1) infection in women are described as part of a prospective 4-year cohort study on perinatal transmission of HIV in Kigali, Rwanda . Two hundred fifteen HIV-seropositive (HIV+) and 216 HIV-seronegative
HIV-1, HIV-2, HTLV-I/II and Treponema pallidum infections: incidence, prevalence, and HIV-2-associated mortality in an occupational cohort in Guinea-Bissau.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):422-8. Unique Identifier : AIDSLINE MED/95323475; Norrgren H; Andersson S; Naucler A; Dias F; Johansson I; Biberfeld G; National Public Health Laboratory, Bissau, Guinea-Bissau.; The prevalence and incidence of human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2), human T-lymphotropic virus types I and II (HTLV-I/II), and syphilitic infections and the association between these infections were determined in a cohort of police officers in Guinea-Bissau .
Exfoliative cytology and electron microscopy in the diagnosis of hairy leukoplakia.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 May;79(5):564-9. Unique Identifier : AIDSLINE MED/95323594; Epstein JB; Fatahzadeh M; Matisic J; Anderson G; BC Cancer Agency, St. Paul's Hospital, Vancouver, Canada.; The diagnosis of lesions clinically suggestive of hairy leukoplakia was assessed by light and electron microscopic examination of cytologic smears. We found exfoliative cytology to be a simple and noninvasive technique that can confirm the clinical diagnosis of hairy leukoplakia. Our results suggest that electron micr
Oral hairy leukoplakia in a child with AIDS.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 May;79(5):570-1. Unique Identifier : AIDSLINE MED/95323595; Laskaris G; Laskaris M; Theodoridou M; Department of Dermatology, A.Sygros Hospital, Medical School; University of Athens, Greece.; A case of a 9-year-old boy with AIDS and severe hairy leukoplakia on the tongue is reported. Clinically it appears as a bilateral whitish-grey, nonremovable lesion on the lateral margins of the tongue with characteristic vertical corrugations. The lesion failed to respond to topical and systemic antifungal treatment.
Altered peptidase and viral-specific T cell response in LMP2 mutant mice.: Immunity. 1994 Oct;1(7):533-41. Unique Identifier : AIDSLINE MED/95323659; Van Kaer L; Ashton-Rickardt PG; Eichelberger M; Gaczynska M; Nagashima K; Rock KL; Goldberg AL; Doherty PC; Tonegawa S; Howard Hughes Medical Institute, Massachusetts Institute of; Technology, Cambridge 02139, USA.; MHC class I molecules present peptides generated by processing of endogenously synthesized proteins to CD8+ T lymphocytes. Recently, large proteolytic complexes, termed proteasomes, were implicated in antigen processing. Two proteasomal subunits, LMP2 and LMP7, are encoded within the MHC class II region, but their pre
Generation and in vivo persistence of polarized Th1 and Th2 memory cells.: Immunity. 1994 Oct;1(7):543-52. Unique Identifier : AIDSLINE MED/95323660; Swain SL; Department of Biology, University of California, San Diego, La; Jolla 92093-0063, USA.; In vitro generated CD4 cell lines and effectors often produce either Th1 or Th2 cytokines, but stimulation of resting CD4 cells from animals leads to production mostly of IL-2 . To determine whether polarization of CD4 effector cells results in development of polarized
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.: Immunity. 1994 Oct;1(7):553-62. Unique Identifier : AIDSLINE MED/95323661; Powrie F; Leach MW; Mauze S; Menon S; Caddle LB; Coffman RL; DNAX Research Institute of Molecular and Cellular Biology; Incorporated, Palo Alto, California 94040, USA.; We have described a murine model of IBD that was induced in C.B-17 scid mice by transfer of the CD45RBhi subpopulation of CD4+ T cells from normal BALB/c mice and could be prevented by cotransfer of the CD45RBlo CD4+ T cell subset. Here we have dissected the mechanism of pathogenesis of IBD in this model and used this
HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.: Immunity. 1995 Jan;2(1):25-36. Unique Identifier : AIDSLINE MED/95323679; Su L; Kaneshima H; Bonyhadi M; Salimi S; Kraft D; Rabin L; McCune JM; HIV Group, Systemix, Incorporated, Palo Alto, California 94304,; USA.; Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within m
On the cellular basis of immunological T cell memory.: Immunity. 1995 Jan;2(1):37-43. Unique Identifier : AIDSLINE MED/95323680; Bruno L; Kirberg J; von Boehmer H; Basel Institute for Immunology, Switzerland.; We have studied memory in T cell receptor (TCR) transgenic mice expressing a Db-restricted TCR specific for the male peptide (H-Y). CD8+ T cells from female TCR transgenic C57BL/6 (B6) mice were activated by transferring them into X-irradiated male (B6 x bm12)F1 hybrid recipients. Subsequently, they were highly purifi
A unique tumor antigen produced by a single amino acid substitution.: Immunity. 1995 Jan;2(1):45-59. Unique Identifier : AIDSLINE GENBANK/U17332; Monach PA; Meredith SC; Siegel CT; Schreiber H; Department of Pathology, University of Chicago, Illinois 60637,; USA.; Mice immunized against a cancer recognize antigens unique to that cancer, but the molecular structures of such antigens are unknown. We isolated CD4+ T cell clones recognizing an antigen uniquely expressed on the UV-induced tumor 6132A; some clones inhibited the growth of tumors bearing the specific antigen. A T cell
Mast cells and T lymphocytes in chronic urticaria.: Clin Exp Allergy. 1995 Apr;25(4):317-22. Unique Identifier : AIDSLINE MED/95323758; Barlow RJ; Ross EL; MacDonald DM; Kobza Black A; Greaves MW; St John's Institute of Dermatology, UMDS, St Thomas's Hospital,; London, UK.; Mast cells are considered to be the primary effector cells in urticaria but it is possible that lymphocytes contribute to the formation of weals by secreting histamine releasing factors. The aim of this study was to examine the population of mast cells and to quantify the T cell subsets and their activation status in
[Effect of low dose rhTNF-alpha on immune function of lymphocytes in burned rats]: Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1995 Jan;11(1):36-9. Unique Identifier : AIDSLINE MED/95323815; Su B; Xue J; Chen Y; Burn Institute, Changhai Hospital, Second Military Medical; University, Shanghai.; SD rats (200-230 g body weight) were randomly divided into three groups: (1) sham burn; (2) burn; (3) burn plus rhTNF-alpha. Third degree burn of 30% TBSA on the trunk was produced in groups 2 and 3. Intravenous rhTNF-alpha(10 micrograms/kg) was administered 6 hours postburn and once daily thereafter for 5 days in gro
Hemophilia and von Willebrand's disease: 2. Management. Association of Hemophilia Clinic Directors of Canada.: Can Med Assoc J. 1995 Jul 15;153(2):147-57. Unique Identifier : AIDSLINE MED/95323851; OBJECTIVE: To present current strategies for the treatment of hemophilia and von Willebrand s disease. OPTIONS: Prophylactic and corrective therapy with hemostatic and adjunctive agents: DDAVP (1-desamino-8-D-arginine vasopressin [desmopressin acetate]), recombinant coagulation products (human Factor VIII and human Fa
Immune parameters of mice bearing human head and neck cancer.: Cancer Immunol Immunother. 1995 May;40(5):283-91. Unique Identifier : AIDSLINE MED/95323946; Taitz A; Petruzzelli G; Pak AS; Wright MA; Matthews JP; Raslan WF; Lozano Y; Young MR; Department of Otolaryngology, Loyola University Stritch School of; Medicine, Maywood, IL 60153, USA.; A xenogeneic human head and neck squamous cell carcinoma (HNSCC) model in immunocompetent mice was evaluated for its requirement of cyclosporine for progressive tumor growth. Tumor growth and T cell functions were assessed in mice receiving cyclosporine treatment for various lengths of time. Tumor cells were injected
Synthesis of sulfated cerebroside analogs having mimicks of ceramide and their anti-human immunodeficiency virus type 1 activities.: Chem Pharm Bull (Tokyo). 1995 Apr;43(4):594-602. Unique Identifier : AIDSLINE MED/95324002; Yoshida H; Ikeda K; Achiwa K; Hoshino H; School of Pharmaceutical Sciences, University of Shizuoka, Japan.; Various sulfated cerebroside analogs, which are mimicks of cerebroside, have been prepared from per-O-acetylated D-glucose, per-O-acetylated D-galactose, and per-O-acetylated D-lactose with ethyleneglycol dodecyl ether, 3-docosyloxy-1-propanol, 2-hydroxymethyl-1,3-O-dimyristyl-1,3-propanediol, and L-serine diamide der
Immunologic contact urticaria due to airborne methylhexahydrophthalic and methyltetrahydrophthalic anhydrides.: Contact Dermatitis. 1995 Apr;32(4):204-9. Unique Identifier : AIDSLINE MED/95324173; Tarvainen K; Jolanki R; Estlander T; Tupasela O; Pfaffli P; Kanerva L; Institute of Occupational Health, Helsinki, Finland.; Acid anhydrides are low-molecular-weight chemicals known to cause respiratory irritancy and allergy. Skin allergy has on rare occasions been reported. 2 workers contracted hives and itching on uncovered skin after 2 months exposure to methyltetrahydrophthalic anhydride (MTHPA) and methylhexahydrophthalic anhydride (MH
Safe sex? [see comments]: Conn Med. 1995 May;59(5):295-8. Unique Identifier : AIDSLINE MED/95324199; Wright R; Duke University, USA.
Anti-CD3-induced apoptosis in T-cells from young and old mice.: Cytometry. 1995 May 1;20(1):33-42. Unique Identifier : AIDSLINE MED/95324304; Chrest FJ; Buchholz MA; Kim YH; Kwon TK; Nordin AA; Clinical Immunology Section, National Institute on Aging, NIH,; Baltimore, Maryland 21224, USA.; Light scatter measurements using flow cytometry indicated that T cells from young and old mice undergo apoptosis following activation with immobilized anti-CD3. The percentage of cells in apoptosis after 20 h activation was significantly greater (p
Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.: Drug Metab Dispos. 1995 Apr;23(4):473-7. Unique Identifier : AIDSLINE MED/95324323; Palamanda JR; Hickman D; Ward A; Sim E; Romkes-Sparks M; Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle; 98195, USA.; Dapsone is used in the treatment of Pneumocystis carinii pneumonia, an opportunistic infection that afflicts acquired immunodeficiency syndrome (AIDS) patients. Inhibition of N-acetyltransferase (NAT)-dependent acetylation of dapsone could increase peak plasma concentrations of dapsone and shift the biotransformation
Endoscopic ultrasound in the diagnosis and staging of gastrointestinal Kaposi's sarcoma.: Endoscopy. 1995 Feb;27(2):191-6. Unique Identifier : AIDSLINE MED/95324474; Zoller WG; Bogner JR; Powitz F; Liess H; Goebel FD; Department of Gastroenterology, Klinikum Innenstadt, Ludwig; Maximilian University of Munich, Germany.; BACKGROUND AND STUDY AIMS: Endoscopic ultrasonography (EUS) has been evaluated for diagnosing and staging of a variety of gastrointestinal tumors, but there are no data on EUS in Kaposi s sarcoma (KS). The aim of the present study was to evaluate the role of EUS in addition to endoscopy in the diagnosis and staging of
Effects of inhalative exposure to dioxins in wood preservatives on cell-mediated immunity in day-care center teachers.: Environ Res. 1995 Feb;68(2):96-105. Unique Identifier : AIDSLINE MED/95324501; Wolf N; Karmaus W; Institute of Medical Sociology, University Hospital Eppendorf,; Hamburg, Germany.; The study investigated the effects of chronic inhalative low-level exposure to dioxins in day-care centers containing wood treated with preservatives on (1) the number of peripheral CD4 and CD8 cells and the CD4:CD8 ratio in peripheral blood and (2) the delayed-type hypersensitivity reaction of the skin (Multitest Mer
Proline motifs in peptides and their biological processing.: FASEB J. 1995 Jun;9(9):736-44. Unique Identifier : AIDSLINE MED/95324794; Vanhoof G; Goossens F; De Meester I; Hendriks D; Scharpe S; Department of Clinical Biochemistry, University of Antwerp,; Wilrijk, Belgium.; Many biologically important peptide sequences contain proline. It confers unique conformational constraints on the peptide chain in that the side-chain is cyclized back onto the backbone amide position. Inside an alpha-helix the possibility of making hydrogen bonds to the preceding turn is lost and a kink will be intr
Hepatitis B virus infection in high-risk inner-city neighborhoods in San Francisco.: Hepatology. 1995 Jul;22(1):44-9. Unique Identifier : AIDSLINE MED/95324898; Siegel D; Alter MJ; Morse S; Center for AIDS Prevention Studies, Institute for Health Policy; Studies, University of California, San Francisco, USA.; To examine the extent of hepatitis B virus infection (HBV) in an inner-city community, we determined the prevalence, incidence, and correlates of HBV seroreactivity in a representative sample of unmarried whites, African-Americans, and Hispanics living in San Francisco during 1988 to 1989 and again 1 year later in 198
Assessment of suitability & ease of performance of seven commercial assay systems for the detection of antibodies to HIV-1.: Indian J Med Res. 1995 May;101:179-82. Unique Identifier : AIDSLINE MED/95324961; Sreedharan A; Jayshree RS; Desai A; Sridhar H; Chandramuki A; Ravi V; Department of Neurovirology, National Institute of Mental Health; & Neuro Sciences, Bangalore.; In this study, we have evaluated the suitability and ease of performance of seven HIV assays namely: Vironostika anti-HIV Uni-Form; Vironostika HIV MIXT; Elavia MIXT; Genelavia MIXT; Serodia-HIV; Immunocomb Bi-spot; and Test pack HIV-1 and 2 Abbott, for use in Indian laboratories. A panel of 41 blind coded Western blo
Patterns in Maryland Medicaid enrollment among persons with AIDS.: Inquiry. 1995 Summer;32(2):184-95. Unique Identifier : AIDSLINE MED/95324985; Bartnyska LM; Schactman M; Hidalgo J; Center for AIDS Services Planning and Development, Maryland; Department of Health and Mental Hygiene, USA.; The percentage of persons with AIDS (PWAs) enrolling in Medicaid is increasing by 3.7% annually. This paper examines the trends in Medicaid enrollment among PWAs and uses a Markov model to analyze the patterns in Medicaid eligibility as enrollees move between assistance categories. We found most Medicaid-eligible PWAs
Costs of medical care and out-of-pocket expenditures for persons with AIDS in the Boston Health Study.: Inquiry. 1995 Summer;32(2):211-21. Unique Identifier : AIDSLINE MED/95324988; Epstein AM; Seage G 3rd; Weissman JS; Cleary PD; Fowler FJ; Gatsonis C; Massagli MP; Stone VE; Coltin K; Craven DE; et al; Department of Health Care Policy, Harvard Medical School, Boston,; MA 02115, USA.; We examined the cost of health care and out-of-pocket medical expenditures for 189 persons with AIDS at three sites in Massachusetts: an HMO; a public hospital immunodeficiency clinic; and a group practice at a major teaching hospital. The mean cost of care during a four-month reference period was $9,093 +/- $12,683 (
Human and viral interleukin-10 in Hodgkin's disease, and its influence on CD4+ and CD8+ T lymphocytes.: Int J Cancer. 1995 Jul 4;62(1):5-10. Unique Identifier : AIDSLINE MED/95325037; Ohshima K; Suzumiya J; Akamatu M; Takeshita M; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.; The Epstein-Barr virus (EBV) is closely related to Hodgkin s disease (HD), while the BCRF-I (viral [v] IL-10) gene of the EBV is highly homologous to the human interleukin-10 (h IL-10) gene. To investigate the relationship of IL-10 and HD, we performed both immunostaining and in situ hybridization (ISH) in 30 cases of
Design and synthesis of amphipathic antimicrobial peptides.: Int J Pept Protein Res. 1995 Apr;45(4):337-47. Unique Identifier : AIDSLINE MED/95325078; Zhong L; Putnam RJ; Johnson WC Jr; Rao AG; Department of Traits and Technology Development, Pioneer Hi-Bred; International, Inc., Johnston, Iowa, USA.; A large proportion of antimicrobial peptides share a common structural feature that is critical to their antimicrobial activity, i.e. amphipathic alpha-helices. The amphipathy of a polypeptide chain can be quantitated through the value of the hydrophobic moment. Generally, antimicrobial peptides are characterized by h
Service delivery to persons with HIV and AIDS.: Iowa Med. 1995 Jun;85(6):250-1. Unique Identifier : AIDSLINE MED/95325131; Saunders E; Dolphin S; Engebretsen B; University of Iowa School of Social Work, USA.
A newly developed immunofluorescence assay for simultaneous detection of antibodies to human immunodeficiency virus type 1 and type 2.: J Virol Methods. 1995 Apr;52(3):239-46. Unique Identifier : AIDSLINE MED/95325380; Tanabe-Tochikura A; Ang Singh MT; Tsuchie H; Zhang J; Paladin FJ; Kurimura T; Department of Viral Infections, Osaka University, Japan.; Immunofluorescence assays (IFA) that simultaneously distinguish between antibodies against closely related human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) infections have not been readily available. Serum specimens from 95 HIV-1-infected, 26 HIV-2-infected and 3 HIV-1/HIV-2 dually infected individuals a
Competitive reverse transcription-polymerase chain reaction for quantitation of feline immunodeficiency virus.: J Virol Methods. 1995 Apr;52(3):335-46. Unique Identifier : AIDSLINE MED/95325389; Vahlenkamp TW; Egberink HF; van Eijk MJ; Slotboom-Kamphorst AM; Verschoor EJ; Horzinek MC; de Ronde A; Institute of Infectious Diseases and Immunology, Faculty of; Veterinary Medicine, Utrecht University, The Netherlands.; A competitive reverse transcription-polymerase chain reaction (RT-PCR) was developed to quantify RNA of feline immunodeficiency virus (FIV) in cats. The assay uses in vitro synthesized RNA derived from the gag region of the FIV genome as a competitive internal control. The synthesized RNA has a 22-base deletion with r
Seasonal changes in juvenile hormone titers and rates of biosynthesis in honey bees.: J Comp Physiol [B]. 1995;165(1):18-28. Unique Identifier : AIDSLINE MED/95325441; Huang ZY; Robinson GE; Department of Entomology, University of Illinois, Urbana 61801,; USA.; Honey bee colonies can respond to changing environmental conditions by showing plasticity in age related division of labor, and these responses are associated with changes in juvenile hormone. The shift from nest tasks to foraging has been especially well characterized; foraging is associated with high juvenile hormon
Nursing: empowerment and the problem of power.: J Adv Nurs. 1995 May;21(5):865-71. Unique Identifier : AIDSLINE MED/95325479; Gilbert T; Cambridgeshire College of Health Studies, Education Centre,; Fulbourn/Ida Darwin Hospital, England.; The concept of empowerment is one which is often invoked in discussions over the nature of nursing practice in a range of health and welfare services. A short excursion through the Cumulative Index to Nursing and Allied Health Literature reveals that over the last 10 years 378 papers are identified which list empowerm
Legal obligations to human immunodeficiency virus--seropositive patients and health care providers.: J Prof Nurs. 1995 May-Jun;11(3):183-91. Unique Identifier : AIDSLINE MED/95325507; Smith MH; University of Southern Mississippi, School of Nursing, Long Beach; 39560, USA.; Balancing the interest of patients against the interest of health care providers with regard to potential or actual human immunodeficiency virus (HIV) has created many legal issues for health care providers. Some health care providers are reluctant to care for patients with HIV and have occasionally refused to treat H
Modulation of intracellular signal transduction pathways by the hepatitis B virus transactivator pX.: J Hepatol. 1995;22(1 Suppl):14-20. Unique Identifier : AIDSLINE MED/95325554; Natoli G; Avantaggiati ML; Chirillo P; De Marzio E; Collepardo D; Falco M; Balsano C; Levrero M; Istituto di I Clinica Medica, University of Rome, Italy.; The mechanisms by which pX, the transactivator of the hepatitis B virus (HBV), exerts its effects on transcription of viral and cellular genes and affects cell-growth regulation have not yet been fully defined. Previous reports suggested the possibility of a direct interaction of pX, which lacks intrinsic DNA-binding
Induction of a glucocorticoid-sensitive F1-anti-parental mechanism that affects engraftment during graft-versus-host disease.: J Immunol. 1995 Jul 1;155(1):172-80. Unique Identifier : AIDSLINE MED/95325586; You-Ten KE; Seemayer TA; Wisse B; Bertley FM; Lapp WS; Department of Physiology, McGill University, Montreal, Quebec,; Canada.; Studies have shown that graft-vs-host disease (GVHD) in animal models induces persistent elevated levels of circulating adrenal glucocorticoids. In this report, we investigated the effects of endogenous glucocorticoids on the outcome of GVHD by adrenalectomizing (ADX) unirradiated (C57BL/6 x A)F1 (B6AF1) mice before G
Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine.: J Immunol. 1995 Jul 1;155(1):462-72. Unique Identifier : AIDSLINE MED/95325623; Mauri-Hellweg D; Bettens F; Mauri D; Brander C; Hunziker T; Pichler WJ; Institute of Immunology and Allergology, Inselspital, Bern,; Switzerland.; To investigate how T cells are involved in hypersensitivity reactions to drugs that become immunogenic after metabolization, e.g., sulfonamides and antiepileptics, we analyzed in vitro the drug-induced activation of CD4+ and CD8+ T cell subsets, cytokine secretion, TCR V beta distribution, and proliferation of T cells
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.: J Immunol. 1995 Jul 1;155(1):473-88. Unique Identifier : AIDSLINE MED/95325624; Rowell JF; Stanhope PE; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.; CD4+ T cell clones specific for the HIV-1 envelope (env) protein are able to recognize not only uninfected APC that have taken up and processed exogenous env protein, but also virally infected cells expressing the env protein. We have evaluated the hypothesis that endocytosis of endogenously synthesized env protein fr
Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice.: J Immunol. 1995 Jul 1;155(1):499-507. Unique Identifier : AIDSLINE MED/95325626; Tamura A; Yui K; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia 19104, USA.; Autoimmune-prone lpr and gld mice carry defects in the apoptosis-mediating cell surface molecule Fas and its ligand, respectively. These mice develop lymphadenopathy because of an age-related accumulation of nonmalignant CD4- CD8- T cells in the peripheral lymphoid organs, suggesting a role for Fas-mediated apoptosis
Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells.: J Immunol. 1995 Jul 1;155(1):76-82. Unique Identifier : AIDSLINE MED/95325630; Gelfanov V; Lai YG; Gelfanova V; Dong JY; Su JP; Liao NS; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan,; 2epublic of China.; The CD8+CD4- (CD8+) murine small intestinal intraepithelial lymphocytes (IELs) contain two subpopulations, one expressing alpha alpha-CD8 homodimers and another alpha beta-CD8 heterodimers. In this study, plate-bound anti-TCR beta-chain (TCR-beta) mAb alone or combined with anti-CD28 mAb is used as a model system to s
Induction of responsiveness in superantigen-induced anergic T cells. Role of ligand density and costimulatory signals.: J Immunol. 1995 Jul 1;155(1):83-92. Unique Identifier : AIDSLINE MED/95325631; Heeg K; Wagner H; Institute of Medical Microbiology and Hygiene, Technical; University of Munich, Germany.; The bacterial superantigen staphylococcal enterotoxin B (SEB) induces in vivo a state of anergy defined by the inability of V beta 8+ CD4+ T cells to produce IL-2 upon restimulation in vitro. However, restimulation in vivo triggers a burst of acutely released lymphokin
Characterization of a soluble, oligomeric HIV-1 gp160 protein as a potential immunogen.: J Immunol Methods. 1995 Jun 14;183(1):103-17. Unique Identifier : AIDSLINE MED/95325634; VanCott TC; Veit SC; Kalyanaraman V; Earl P; Birx DL; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850, USA.; We have assessed the oligomeric structure and antigenic properties of an affinity purified gp160 protein (oligo-gp160) using biosensor technology. Sucrose gradient purification analysis identified the existence of tetrameric, dimeric and monomeric forms of the protein. Reactivity to a broad panel of monoclonal antibod
Analysis of human CD4-antibody interaction using the BIAcore system.: J Immunol Methods. 1995 Jun 14;183(1):141-8. Unique Identifier : AIDSLINE MED/95325638; Velge-Roussel F; Breton P; Lescure F; Guillon X; Bout D; Hoebeke J; CJF INSERM 93-09 Immunologie des Maladies Infectieuses, Equipe; Associee INRA d'Immunologie Parasitaire, UFR des Sciences; Pharmaceutiques, Tours, France.; Interaction between CD4 cell surface protein and HIV-bearing gp120 has been described as the initial step for HIV entry into host cells. Some anti-CD4 antibodies were shown to inhibit this interaction. Biosensor studies using the BIAcore were performed to determine kinetic and thermodynamic parameters of the interacti
Surface plasmon resonance based kinetic studies of zinc finger-DNA interactions.: J Immunol Methods. 1995 Jun 14;183(1):175-82. Unique Identifier : AIDSLINE MED/95325643; Yang WP; Wu H; Barbas CF 3rd; Department of Molecular Biology, Scripps Research Institute, La; Jolla, CA 92037, USA.; Libraries of the zinc finger DNA binding protein, Zif268, have been constructed and selected for affinity and specificity toward DNA targets using the phage display technique (Wu et al., 1995). Mutant proteins were purified to homogeneity and were characterized for their ability to interact with their DNA targets usin
Measuring interactions of MHC class I molecules using surface plasmon resonance.: J Immunol Methods. 1995 Jun 14;183(1):77-94. Unique Identifier : AIDSLINE MED/95325651; Khilko SN; Jelonek MT; Corr M; Boyd LF; Bothwell AL; Margulies DH; Molecular Biology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892-1892, USA.; To examine the molecular interactions between major histocompatibility complex (MHC)-encoded molecules and peptides, monoclonal antibodies (mAbs), or T cell receptors, we have developed model systems employing genetically engineered soluble MHC class I molecules (MHC-I), synthetic peptides, purified mAbs, and engineer
Diarrhea in terminally ill patients: pathophysiology and treatment.: J Pain Symptom Manage. 1995 May;10(4):298-309. Unique Identifier : AIDSLINE MED/95325695; Mercadante S; Department of Anesthesia and Intensive Care, Buccheri La Ferla; Fatebenefratelli Hospital, Palermo, Italy.; Diarrhea is a distressing symptom that limits the quality of life in terminally ill patients. In these patients, many factors can affect intestinal secretion, absorption, and motility, including drugs, infective agents, antibiotics, chemotherapy, radiotherapy, surgery, malnutrition, neuroendocrine tumors, and mechanic
A micro-suspension-test for evaluation of disinfectants against human immunodeficiency virus.: Kansenshogaku Zasshi. 1995 May;69(5):532-8. Unique Identifier : AIDSLINE MED/95325705; Shimakoshi Y; Sano K; Nakano T; Nakamura T; Ohshiba S; Katsu K; Nakai M; Second Department of Internal Medicine, Osaka Medical College,; Japan.; We devised a micro-suspension-test to evaluate disinfectants against human immunodeficiency virus type-1 (HIV-1) and confirmed its reliability. Suspensions of persistently HIV-1-infected Molt-4 cells were used as targets of disinfectants and residual infectivity was measured by an infectivity assay: after cocultivatio
Iron in CNS disease.: J Neuropathol Exp Neurol. 1995 Jul;54(4):477-86. Unique Identifier : AIDSLINE MED/95325846; Gelman BB; Department of Pathology, University of Texas Medical Branch,; Galveston 77550, USA.
HIV infection of human choroid plexus: a possible mechanism of viral entry into the CNS.: J Neuropathol Exp Neurol. 1995 Jul;54(4):497-503. Unique Identifier : AIDSLINE MED/95325848; Falangola MF; Hanly A; Galvao-Castro B; Petito CK; Department of Pathology, University of Miami School of Medicine,; FL 33136, USA.; The present study examines the hypothesis that HIV infection of the choroid plexus (CPx) may be an important site of viral entry into the brain. Formalin-fixed, paraffin-embedded CPx was obtained from 25 patients with AIDS and 13 nonAIDS patients and was processed for light microscopy and for immunohistochemical detec
High-risk vulnerable populations and volunteers: a model of education and service collaboration.: J Community Health Nurs. 1995;12(2):111-9. Unique Identifier : AIDSLINE MED/95325861; Hutchison RR; Quartaro EG; Department of Graduate Nursing, Seton Hall University, Orange, NJ; 07079-2693, USA.; Extending our earlier work (Hutchison & Quartaro, 1993) describing a training program for volunteers caring for high-risk vulnerable populations, we identify and explicate factors contributing to the successful collaboration of education and service organizations. Addressing the management of linkages essential to
Further simplification of ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) for anti-HTLV-I IgG using microplates and fluororeader.: J Clin Lab Anal. 1995;9(3):204-11. Unique Identifier : AIDSLINE MED/95325965; Ishikawa S; Hashida S; Nakamoto H; Tanaka S; Kojima M; Ishikawa E; Department of Biochemistry, Medical College of Miyazaki, Japan.; In a previously reported ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) for anti-HTLV-I IgG, polystyrene beads were handled with tweezers, and bound beta-D-galactosidase activity was measured with a fluorometer. The use of tweezers was causative of false-positivity by carryover, and tes
Assessment of a multistage therapeutic community for drug-involved offenders.: J Psychoactive Drugs. 1995 Jan-Mar;27(1):109-16. Unique Identifier : AIDSLINE MED/95325970; Martin SS; Butzin CA; Inciardi JA; Center for Drug & Alcohol Studies, University of Delaware,; Newark, 19716, USA.; A multistage therapeutic community (TC) treatment program has been instituted in the Delaware correctional system. Components in place long enough to provide follow-up data consist of a TC in prison and a transitional TC outside the prison for parolees. Baseline data at release from prison, and outcome data six months
The T-cell receptor V beta repertoire in naive and human immunodeficiency virus-1 (HIV-1) infected chimpanzees.: J Med Primatol. 1994 Oct;23(8):432-41. Unique Identifier : AIDSLINE MED/95326129; Boldt-Houle DM; Nigida SM Jr; Rinaldo CR Jr; Ehrlich GD; Department of Pathology, University of Pittsburgh School of; Medicine, PA 15261, USA.; Using a panel of human T-cell receptor (TCR) variable region beta chain (V beta) polymerase chain reaction (PCR) primers, we performed cross-sectional and longitudinal analyses of the TCR V beta repertoire in naive and HIV-1 infected chimpanzees. We demonstrate that our TCR PCR primer panel will support amplification
[Problems of HIV infection and tuberculosis (TB) in Asia--an epidemetric model analysis of the impact of HIV infection on TB control]: Nippon Kyobu Shikkan Gakkai Zasshi. 1994 Dec;32 Suppl:216-22. Unique Identifier : AIDSLINE MED/95326398; Mori T; Research Institute of Tuberculosis, Japan Anti-Tuberculosis; Association.; The widespread HIV infection in some developed and developing countries is posing serious problems for the control of TB. An edpidemetric model was built to simulate the dual epidemics of HIV infection and TB in the developing world s population. It was shown that HIV infection may greatly increase the prevalence of T
Activation of HIV transcription by human foamy virus in transgenic mice.: Lab Invest. 1995 Jul;73(1):103-10. Unique Identifier : AIDSLINE MED/95326605; Marino S; Kretschmer C; Brandner S; Cavard C; Zider A; Briand P; Isenmann S; Wagner EF; Aguzzi A; Institute of Neuropathology, University Hospital, Zurich,; Switzerland.; BACKGROUND: Although infection by HIV-1 is the primary cause of AIDS, cofactorial agents of an infectious nature may be involved in the pathogenesis of the disease. The present work addresses the cofactorial potential of human foamy virus (HFV) in AIDS. It has been suggested that HFV seroprevalence reaches 5% in East
Impact of a school-based AIDS prevention program on risk and protective behavior for newly sexually active students.: J Sch Health. 1995 Apr;65(4):145-51. Unique Identifier : AIDSLINE MED/95326627; Levy SR; Perhats C; Weeks K; Handler AS; Zhu C; Flay BR; Prevention Research Center, University of Illinois at Chicago; 60607, USA.; This project assessed the impact of a school-based AIDS prevention program on student participation in sexual risk and protective behaviors such as use of condoms and use of condoms with foam and intention to participate in such behaviors. The paper focuses on students who became sexually active for the first time bet
We can protect ourselves: a rhyming puppet show about HIV prevention.: J Sch Health. 1995 Apr;65(4):152-4. Unique Identifier : AIDSLINE MED/95326628; Zaccone-Tzannetakis PR; Seton Hall University, College of Education and Human Services,; South Orange, NJ 07079, USA.
Rolling the dice [editorial]: J Tenn Med Assoc. 1995 May;88(5):198-200. Unique Identifier : AIDSLINE MED/95326645; Thomison JB
[Rapid progression to AIDS in a patient with infection from a strain of syncytium forming HIV-1]: Med Clin (Barc). 1995 Jun 17;105(3):99-100. Unique Identifier : AIDSLINE MED/95326710; Soriano V; Heredia A; Bravo R; Gutierrez M; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; A woman who had recently become infected with HIV-1 after sexual relations with a seropositive subject presented a rapid fall in CD4+ T lymphocytes and evolved to AIDS 13 months after primoinfection. The most plausible cause for the rapid disease progression in this patient was the observation of a viral syncytium for
Staging system for clinical AIDS patients. Royal Free/Chelsea and Westminster Hospitals Collaborative Group [see comments]: Lancet. 1995 Jul 1;346(8966):12-7. Unique Identifier : AIDSLINE MED/95326728; Mocroft AJ; Johnson MA; Sabin CA; Lipman M; Elford J; Emery V; Morcinek J; Youle M; Janossy G; Lee CA; et al; Department of Public Health, Royal Free Hospital and School of; Medicine, London.; Although there are wide differences in prognosis between patients with AIDS they are often thought of as a single homogeneous group. We think a simple staging system that accounts for important prognostic factors including type and number of AIDS diseases and the CD4 lymphocyte count is required. We followed 363 AIDS
Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.: Lancet. 1995 Jul 1;346(8966):26-8. Unique Identifier : AIDSLINE MED/95326733; Saville MW; Lietzau J; Pluda JM; Feuerstein I; Odom J; Wilson WH; Humphrey RW; Feigal E; Steinberg SM; Broder S; et al; National Cancer Institute, Bethesda, MD 20892, USA.; We investigated whether paclitaxel was active in AIDS-associated Kaposi s sarcoma. We gave 135 mg/m2 intravenously over 3 hours every 21 days. Follow-up is available on the first 20 patients, most of whom had advanced Kaposi s sarcoma and severe immunocompromise. Neutropenia was the most frequent dose-limiting toxic e
HIV-1 infection in commercial plasma donors in China [letter]: Lancet. 1995 Jul 1;346(8966):61-2. Unique Identifier : AIDSLINE MED/95326773; Wu Z; Liu Z; Detels R
Lawsuit brought by US HIV-infected haemophiliacs [news]: Lancet. 1995 Jul 8;346(8967):110. Unique Identifier : AIDSLINE MED/95326779; Washburn L
Cimetidine and survival with colorectal cancer [letter; comment]: Lancet. 1995 Jul 8;346(8967):115. Unique Identifier : AIDSLINE MED/95326781; Matsumoto S
Fulminant cryptococcal infections in HIV-infected patients on oral fluconazole [letter]: Lancet. 1995 Jul 8;346(8967):118. Unique Identifier : AIDSLINE MED/95326786; Viard JP; Hennequin C; Fortineau N; Pertuiset N; Rothschild C; Zylberberg H
Treatment of Kaposi's sarcoma and other manifestations of AIDS with human chorionic gonadotropin [letter] [see comments]: Lancet. 1995 Jul 8;346(8967):118-9. Unique Identifier : AIDSLINE MED/95326787; Harris PJ
CDC recommends wider prenatal HIV screening [news]: Lancet. 1995 Jul 15;346(8968):172. Unique Identifier : AIDSLINE MED/95326840; McCarthy M
Attenuated vaccines for AIDS? [letter; comment]: Lancet. 1995 Jul 15;346(8968):177-8. Unique Identifier : AIDSLINE MED/95326842; Ruprecht RM; Baba TW; Greene MF
Attenuated vaccines for AIDS [letter]: Lancet. 1995 Jul 15;346(8968):179. Unique Identifier : AIDSLINE MED/95326843; Victorino RM; Sousa AE
Familial clustering of HTLV-I infection in southeastern Italy [letter]: Lancet. 1995 Jul 15;346(8968):179-80. Unique Identifier : AIDSLINE MED/95326844; Chironna M; Quarto M; Specchia G; Liso V; Barbuti S
Modulation of HIV-LTR activity by ras oncogenes.: New Microbiol. 1995 Apr;18(2):111-6. Unique Identifier : AIDSLINE MED/95326949; Lembo D; Angeretti A; Gaboli M; Cavallo R; Landolfo S; Institute of Microbiology of Novara, Institute of Microbiology of; Turin, University of Turin, Italy.; Cotransfection of NIH 3T3 cells with a mammalian expression vector containing a v-Ha-ras gene, together with a plasmid carrying the human immunodeficiency virus (HIV) long terminal repeat (LTR) linked to the chloramphenicol acetyl transferase (CAT) reporter gene, significantly stimulated CAT activity. High HIV LTR act
Engineering human monoclonal antibody fragments: a recombinant enzyme-linked Fab.: New Microbiol. 1995 Apr;18(2):127-33. Unique Identifier : AIDSLINE MED/95326951; Burioni R; Plaisant P; Riccio ML; Rossolini GM; Santangelo R; Vannini A; Satta G; Istituto di Microbiologia, Universita Cattolica del S. Cuore,; Roma, Italy.; A new plasmid vector, pCRP, allowing the expression of human recombinant monoclonal antibody Fab fragments fused with a bacterial acid phosphatase has been constructed. pCRP can accept heavy- and light-chain cDNAs cloned from combinatorial antibody libraries displayed on filamentous phages with the pCombIII system and
A new plasmid cloning vector for direct detection of recombinant clones, based on inactivation of a bacterial acid phosphatase-encoding gene.: New Microbiol. 1995 Apr;18(2):201-6. Unique Identifier : AIDSLINE MED/95326960; Burioni R; Plaisant P; Riccio ML; Rossolini GM; Satta G; Istituto di Microbiologia, Universita Cattolica del S. Cuore,; Rome, Italy.; A new plasmid cloning vector for Escherichia coli (pPhoR) suitable for direct detection of recombinant clones has been constructed. The plasmid is a multicopy of a vector which carries a pUC-derived origin of replication and beta-lactamase gene, and the phoN acid phosphatase-encoding gene from Providencia stuartii. Fo
HIV exposure in health care [letter; comment]: Med J Aust. 1995 Jun 19;162(12):667. Unique Identifier : AIDSLINE MED/95326997; Butler RJ
Clinical perspectives and current trends of HIV infection in the newborn and child.: Neonatal Netw. 1995 Apr;14(3):21-34; quiz 35-6. Unique Identifier : AIDSLINE MED/95327035; Shannon L; Pediatric AIDS and HIV infection are issues that have and will continue to receive more and more attention. With the increasing number of children born to HIV-infected women, there are many unanswered questions concerning maternal and child health organizations. This article provides information on the current epidemi
HIV vaccines. Back to primary school [news]: Nature. 1995 Jul 13;376(6536):115. Unique Identifier : AIDSLINE MED/95327178; Moore JP
Causes of HIV diversity [letter]: Nature. 1995 Jul 13;376(6536):125. Unique Identifier : AIDSLINE MED/95327182; Bonhoeffer S; Holmes EC; Nowak MA
Fear and trembling in North Carolina. The barriers to primary medical and dental care for AIDS patients.: N C Med J. 1995 Jun;56(6):252-5. Unique Identifier : AIDSLINE MED/95327199; Simmons JD; Harley C; Division of Adult Health Promotion, NC Department of Environment,; Health and Natural Resources, Raleigh 27611-7687, USA.
[Survival and mortality in a cohort of heroin addicts in 1985-1994]: Minerva Med. 1995 Mar;86(3):97-9. Unique Identifier : AIDSLINE MED/95327238; Brancato V; Delvecchio G; Simone P; USSL 25-Clusone, Bergamo, Servizio di Medicina di Base.; Between 1985 and 1994, 138 intravenons drug addicts were observed, 62 were HIV ab positive. 26 patients died (10 overdose and 9 AIDS). AIDS is, at present, the most frequent cause of death.
HIV infection and neuropsychological impairment [letter; comment]: N Z Med J. 1995 Jun 14;108(1001):235. Unique Identifier : AIDSLINE MED/95327292; Marsh NV
Behaviour ignores HIV knowledge [news]: Occup Health (Lond). 1995 Jun;47(6):188. Unique Identifier : AIDSLINE MED/95327314
AIDS and the business traveller.: Occup Health (Lond). 1995 Jun;47(6):194-8. Unique Identifier : AIDSLINE MED/95327315; Pratt RJ
Evaluation of certain immunity parameters in rheumatoid arthritis, treated with cortisone.: Panminerva Med. 1994 Dec;36(4):188-91. Unique Identifier : AIDSLINE MED/95327368; Venarucci D; Catalini P; Scendoni P; Venarucci V; Casado A; De La Torre R; Department of Biochemistry-INRCA, Fermo AP, Italy.; The authors present their study on interleukin-2 receptors (IL-2R), transferrin receptors (R-Tr), CD-4/CD-8 ratio, T-lymphocytes after therapy with a corticosteroid (125 mg/die), in 7 female geriatric patients suffering from rheumatoid arthritis. The study was performed with conjugated monoclonal antibody marking the
Disseminated Penicillium marneffei: presenting illness of advanced HIV infection; a clinicopathological review, illustrated by a case report.: Pathology. 1995 Jan;27(1):101-5. Unique Identifier : AIDSLINE MED/95327375; Heath TC; Patel A; Fisher D; Bowden FJ; Currie B; Royal Darwin Hospital, Casuarina, Northern Territory.; BACKGROUND: Until recently Penicillium marneffei rarely caused human disease. It is now a frequently encountered opportunistic mycosis in HIV positive residents of, and travellers to, south-east Asia. AIMS: To review aspects of clinical presentation, pathology, treatment, epidemiology and ecology of P. marneffei. To r
Nosocomial transmission of hepatitis A in a pediatric hospital traced to an anti-hepatitis A virus-negative patient with immunodeficiency.: Pediatr Infect Dis J. 1995 Apr;14(4):261-6. Unique Identifier : AIDSLINE MED/95327440; Burkholder BT; Coronado VG; Brown J; Hutto JH; Shapiro CN; Robertson B; Woodruff BA; Hepatitis Branch, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA.; From July through October 1991, an outbreak of hepatitis A virus (HAV) infection involving 26 hospital staff, inpatients and household contacts occurred in a pediatric hospital. All ill staff members had cared for one inpatient who had profuse diarrhea with gross fecal contamination of the environment, negative HAV se
Invasive group B streptococcal disease in children beyond early infancy.: Pediatr Infect Dis J. 1995 Apr;14(4):278-81. Unique Identifier : AIDSLINE MED/95327443; Hussain SM; Luedtke GS; Baker CJ; Schlievert PM; Leggiadro RJ; Department of Pediatrics, University of Tennessee, Memphis, USA.; There is little information available on invasive group B Streptococcus (GBS) infection in pediatric patients older than 3 months of age. Review of infection control records at LeBonheur Children s Medical Center from January 1, 1986, to June 30, 1993, identified 143 patients with a positive GBS culture from normally
Prolonged influenza A infection responsive to rimantadine therapy in a human immunodeficiency virus-infected child.: Pediatr Infect Dis J. 1995 Apr;14(4):332-4. Unique Identifier : AIDSLINE MED/95327459; Evans KD; Kline MW; Baylor College of Medicine, Houston, Texas, USA.
Auxiliary accused of making 'HIV list' may return to work [news]: Nurs Times. 1995 May 31-Jun 6;91(22):6. Unique Identifier : AIDSLINE MED/95327495; Taylor A
HIV has affected approximately 18 million adults worldwide [news]: Nurs Times. 1995 May 31-Jun 6;91(22):6. Unique Identifier : AIDSLINE MED/95327496
Screening for unsuspected HIV in infants [news]: Nurs Times. 1995 Jun 7-13;91(23):10. Unique Identifier : AIDSLINE MED/95327503; Evans JA; Marriage SC; Walters MD; Levin M
Winning a losing battle.: Nurs Times. 1995 Jun 7-13;91(23):40-3. Unique Identifier : AIDSLINE MED/95327514; Winson G
Influence of the alv6 recombinant avian leukosis virus transgene on production traits and infection with avian tumor viruses in chickens.: Poult Sci. 1995 May;74(5):852-63. Unique Identifier : AIDSLINE MED/95327605; Gavora JS; Benkel B; Spencer JL; Gagnon C; Crittenden LB; Centre for Food and Animal Research, Agriculture and Agri-Food; Canada, Ottawa, Ontario.; The biological costs of the alv6 recombinant transgene that in chickens induces dominant resistance to the subgroup A avian leukosis virus (ALV), in terms of effects on production traits, were studied. Four generations of White Leghorn chickens of Line TR, segregating for alv6 but free of endogenous viral genes, as we
Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.: Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6254-8. Unique Identifier : AIDSLINE MED/95327625; Seung LP; Rowley DA; Dubey P; Schreiber H; Department of Pathology, University of Chicago, IL 60637, USA.; During tumor progression, variants may arise that grow more vigorously. The fate of such variants depends upon the balance between aggressiveness of the variant and the strength of the host immunity. Although enhancing host immunity to cancer is a logical objective, eliminating host factors necessary for aggressive gr
The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses.: Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6259-63. Unique Identifier : AIDSLINE MED/95327626; Ishikawa T; Ganem D; Howard Hughes Medical Institute, University of California Medical; Center, San Francisco 94143-0502, USA.; In addition to their well-recognized hepatotropism, all hepatitis B viruses (HBVs) display marked species specificity, growing poorly or not at all in species other than those closely related to their natural hosts. We have examined the molecular basis for this narrow host range, using duck HBV (DHBV) and heron HBV (H
Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.: Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6444-8. Unique Identifier : AIDSLINE MED/95327663; Sakihama T; Smolyar A; Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute,; Boston, MA, USA.; Previous studies have failed to detect an interaction between monomeric soluble CD4 (sCD4) and class II major histocompatibility complex (MHC) proteins, suggesting that oligomerization of CD4 on the cell surface may be required to form a stable class II MHC binding site. To test this possibility, we transfected the F4
Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.: Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6577-81. Unique Identifier : AIDSLINE MED/95327690; Muller JR; Janz S; Goedert JJ; Potter M; Rabkin CS; Laboratory of Genetics, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892, USA.; We studied blood lymphocytes of human immunodeficiency virus (HIV)-seropositive and -negative homosexual men for the presence of T(8;14) translocations that recombine c-myc and immunoglobulin heavy-chain (IgH) mu/IgH alpha switch regions. Clones with T(8;14) translocations were detected in 10.5% (12/114) of the HIV-po
Assessing patients with HIV-associated dementia.: Prof Nurse. 1995 Jun;10(9):588-9. Unique Identifier : AIDSLINE MED/95327712; Lennox S; Ward G; HIV-associated dementia may pose communication challenges to healthcare staff. It is essential to obtain an accurate assessment of the confusion in order to achieve a baseline from which to evaluate a patient. It is important to communicate in a way that conveys worth and value to
Exercise and human immunodeficiency virus (HIV-1) infection.: Sports Med. 1995 Apr;19(4):235-9. Unique Identifier : AIDSLINE MED/95327855; Lawless D; Jackson CG; Greenleaf JE; Rockefeller University, New York, New York, USA.
Spread of maternal HIV infection in Scotland from 1990 to 1992.: Scott Med J. 1995 Feb;40(1):12-4. Unique Identifier : AIDSLINE MED/95327900; Tappin DM; Johnstone FD; Smith R; Girdwood RW; Follett EA; Davidson CF; Department of Child Health, Royal Hospital for Sick Children,; Glasgow.; In Scotland since January 1990, unlinked anonymous testing of Guthrie cards has documented maternal HIV-1 antibody in neonatal blood. District postcode and quarter year of birth determined prevalence and spread of infection. The Fujirebio particle agglutination assay screened for HIV-1 antibody, with confirmation by E
Controversy: is KS really caused by new herpesvirus? [news] [see comments] [published erratum appears in Science 1995 Aug 11;269(5225):745]: Science. 1995 Jun 30;268(5219):1847-8. Unique Identifier : AIDSLINE MED/95327923; Cohen J
Italy. Returning emigres add new luster to AIDS research [news]: Science. 1995 Jul 7;269(5220):24-5. Unique Identifier : AIDSLINE MED/95327944; Balter M
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.: Science. 1995 Jul 7;269(5220):79-81. Unique Identifier : AIDSLINE MED/95327953; Migone TS; Lin JX; Cereseto A; Mulloy JC; O'Shea JJ; Franchini G; Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung, and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892, USA.; Human T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy). HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 ( IL-2 )-dependen
Human immunodeficiency virus-related immune thrombocytopenia.: Semin Thromb Hemost. 1995;21(1):68-75. Unique Identifier : AIDSLINE MED/95327968; Bierling P; Bettaieb A; Oksenhendler E; Laboratoire d'Immunologie Leuco-plaquettaire, Centre de; Transfusion, Creteil, France.
[Seropositive patients or patients with AIDS. The role of the psychiatrist]: Soins. 1995 Jun;(597):42-4. Unique Identifier : AIDSLINE MED/95327989; Rey-Camet M
Monocyte function in cattle experimentally infected with bovine immunodeficiency-like virus.: Vet Immunol Immunopathol. 1995 Mar;45(1-2):31-43. Unique Identifier : AIDSLINE MED/95328251; Rovid AH; Carpenter S; Roth JA; Department of Microbiology, Immunology, and Preventive Medicine,; Iowa State University, Ames 50011, USA.; The effects of bovine immunodeficiency-like virus (BIV) on monocyte function were examined in experimentally infected cattle and in monocytes infected in vitro. Infection with the R29 isolate of BIV appeared to have relatively little effect on monocyte function in cattle during the first 2 years postinfection (PI). Fo
Functional and phenotypic analysis of in vitro stimulated canine peripheral blood mononuclear cells.: Vet Immunol Immunopathol. 1995 Mar;45(1-2):55-71. Unique Identifier : AIDSLINE MED/95328253; Rivas AL; Kimball ES; Quimby FW; Gebhard D; Department of Pathology, New York State College of Veterinary; Medicine, Cornell University, Ithaca 14850, USA.; The inter-species cross-reactivity of cytokine bioassays for interleukin-2 (IL2) and interleukin-6 (IL6) was investigated in the canine species. The kinetics of normal canine peripheral blood mononuclear cells (PBMC) stimulated with pokeweed mitogen (PWM), were analyzed in terms of cytokine release and responsiveness
Response of the regional lymph node to bluetongue virus infection in calves.: Vet Immunol Immunopathol. 1995 Mar;45(1-2):73-84. Unique Identifier : AIDSLINE MED/95328254; Barratt-Boyes SM; Rossitto PV; Taylor BC; Ellis JA; MacLachlan NJ; Department of Veterinary Pathology, Microbiology and Immunology,; School of Veterinary Medicine, University of California, Davis; 95616, USA.; Bluetongue virus (BTV) infection of cattle is characterized by prolonged cell-associated viremia. In an effort to further evaluate the antiviral response of BTV-infected cattle, the role of the regional lymph node (LN) in the immune response of calves to BTV was characterized. Calves were inoculated with BTV in the sk
[Effective knowledge propaganda is the chief strategy for preventing HIV infection among adolescents]: Vrach Delo. 1994 Sep-Dec;(9-12):192-6. Unique Identifier : AIDSLINE MED/95328291; Usenko AD; Grazhdanov NP; Stepanets VI; Neshcheret EN; Maksiutenko EV
[The epidemiological characteristics of HIV infection in Ukraine]: Vrach Delo. 1994 Sep-Dec;(9-12):3-7. Unique Identifier : AIDSLINE MED/95328295; Kobyshcha IuV; Shcherbinskaia AM; Chentsova NP; Goregliad NI; Papushina II; Kruglov IuV; Kislykh EI; Morozov VF; Vatamaniuk MIu; Maksimenok EV; et al; The paper presents results of screening tests involving different groups of the population in the Ukraine , for antibodies to HIV, findings from epidemiologic investigation into cases with HIV-infection, with a view to outlining epidemiologic situation and assessing effectiveness o
Idiopathic CD4+ T-lymphocytopenia in HIV seronegative men with hemophilia and sex partners of HIV seropositive men. Multicenter Hemophilia Cohort Study.: Am J Hematol. 1995 Jul;49(3):201-6. Unique Identifier : AIDSLINE MED/95328539; O'Brien TR; Diamondstone L; Fried MW; Aledort LM; Eichinger S; Eyster ME; Hilgartner MW; White G; Di Bisceglie AM; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852, USA.; Persons with hemophilia or other HIV-1 risk factors may be more likely to have idiopathic CD4+ T-lymphocytopenia (ICL). We determined the frequency of ICL in prospectively followed cohorts of HIV-1 seronegative hemophilic men and seronegative female sex partners of HIV-1 infected hemophilic men, and examined factors p
Higher cytotoxic activity and increased levels of IL-1 beta, IL-6, and TNF-alpha in patients undergoing cardiopulmonary bypass.: Am J Hematol. 1995 Jul;49(3):237-9. Unique Identifier : AIDSLINE MED/95328544; Marti F; Munoz J; Peiro M; Bertran E; Ferran C; Octavio C; Garcia J; Rueda F; Department of Cryobiology and Cell Therapy, Ciutat Sanitaria i; Universitaria de Bellvitge, L'Hospitalet de Llobregat,; Barcelona, Spain.; Extracorporeal circulation (EC) by surgical bypass is often associated with a systemic inflammatory response. The purpose of this study was to assess the effect of EC on the serum levels of pro-inflammatory mediators Interleukin (IL)-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, and soluble CD-23. Peripheral blood
Hyperferritinemia in reactive hemophagocytic syndrome report of four adult cases.: Am J Hematol. 1995 Jul;49(3):247-9. Unique Identifier : AIDSLINE MED/95328548; Koduri PR; Carandang G; DeMarais P; Patel AR; Department of Medicine, Cook County Hospital, Chicago, Illinois,; USA.; Four patients were diagnosed with reactive hemophagocytic syndrome (RHPS) during a 7 month period. Of these, three patients were diagnosed with acquired immunodeficiency syndrome complicated by disseminated Mycobacterium tuberculosis infection, incompletely treated Pneumocystis carinii pneumonia and disseminated histo
Case reports: pericarditis and lymphadenitis due to Rhodococcus equi.: Am J Med Sci. 1995 Jul;310(1):31-3. Unique Identifier : AIDSLINE MED/95328569; Lee-Chiong T; Sadigh M; Simms M; Buller G; Department of Internal Medicine, Yale-New Haven Hospital, New; Haven, Connecticut, USA.; Most patients with Rhodococcus equi infection are immunocompromised by either HIV infection, malignancy, or medication. Diagnosis is frequently missed or delayed because the organisms, resembling diphtheroids on smears, may be regarded as contaminants. Their clinical, pathologic, histochemical, and microbiologic resem
Human immunodeficiency virus-1 gp120 and gp160 envelope proteins modulate mesangial cell gelatinolytic activity.: Am J Pathol. 1995 Jul;147(1):25-32. Unique Identifier : AIDSLINE MED/95328620; Singhal PC; Sagar S; Chandra D; Garg P; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; Patients with human immunodeficiency virus (HIV) infection often develop glomerular lesions (mesangial expansion and sclerosis). Modulation of matrix degradation may be important in the expansion of the mesangium. We studied the effect of HIV sera and HIV-1 envelope glycoproteins on gelatinolytic activity of human mes
Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.: Am J Pathol. 1995 Jul;147(1):53-67. Unique Identifier : AIDSLINE MED/95328623; Wyss-Coray T; Feng L; Masliah E; Ruppe MD; Lee HS; Toggas SM; Rockenstein EM; Mucke L; Department of Neuropharmacology, Scripps Research Institute,; California, USA.; A number of important neurological diseases, including HIV-1 encephalitis, Alzheimer s disease, and brain trauma, are associated with increased cerebral expression of the multifunctional cytokine transforming growth factor-beta 1 (TGF-beta 1). To determine whether overexpression of TGF-beta 1 within the central nervou
The prevalence of patient disclosure of HIV infection to doctors [letter]: Am J Public Health. 1995 Jul;85(7):1018-9. Unique Identifier : AIDSLINE MED/95328641; Marks G; Mason HR; Simoni JM
Tuberculosis knowledge among New York City injection drug users.: Am J Public Health. 1995 Jul;85(7):985-8. Unique Identifier : AIDSLINE MED/95328665; Wolfe H; Marmor M; Maslansky R; Nichols S; Simberkoff M; Des Jarlais D; Moss A; Division of Epidemiology and Biostatistics, New York University; Medical Center, NY 10010, USA.; Structured interviews measuring tuberculosis knowledge were administered to 494 New York City injection drug users, 31% of whom reported a history of having a reactive tuberculin skin test. Medical records review of a subsample confirmed the validity of self-reported data. Most respondents understood the mechanisms of
Peripheral blood T lymphocytes in seasonal bronchial asthma.: Allergy. 1995 Feb;50(2):152-6. Unique Identifier : AIDSLINE MED/95328677; Monteseirin J; Guardia P; Delgado J; Llamas E; Palma J; Conde A; Conde J; Servicio de Inmunologia y Alergia, Hospital Universitario Virgen; Macarena, Seville, Spain.; Variations in T lymphocytes in asthmatic patients are related to disease severity. However, the effects of natural exposure to pollens on peripheral blood T lymphocytes have not been clarified. In this paper, the effects on peripheral blood CD4 and CD8 lymphocytes from pollen-sensitive subjects and from nonatopic dono
Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and vitamin E status.: Allergy. 1995 Feb;50(2):157-61. Unique Identifier : AIDSLINE MED/95328678; Miguez-Burbano MJ; Shor-Posner G; Fletcher MA; Lu Y; Moreno JN; Carcamo C; Page B; Quesada J; Sauberlich H; Baum MK; Department of Epidemiology and Public Health, University of Miami; School of Medicine, FL 33101, USA.; Our recent studies have demonstrated that in early HIV-1 infection, elevation of plasma immunoglobulin E (IgE) levels precedes the decline of CD4 cell count and is influenced by vitamin E status. In order to further investigate the role of IgE elevation in HIV-1 infection, we determined IgE levels in HIV-1-seropositiv
Inhibition of human immunodeficiency virus expression by sense transcripts encoding the retroviral leader RNA.: Antiviral Res. 1995 Mar;26(2):101-15. Unique Identifier : AIDSLINE MED/95328855; Berkhout B; van Wamel JL; Department of Virology, Academic Medical Center, University of; Amsterdam, The Netherlands.; Towards gene therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infections, we tested the potency of several antiviral constructs in transient HIV-1 production assays. Whereas little effect was obtained with antisense- and TAR decoy-constructs, we measured efficient inhibition of HIV-1 mRNA trans
Inhibition of herpes simplex virus type 1, respiratory syncytial virus and echovirus type 11 by peroxidase-generated hypothiocyanite.: Antiviral Res. 1995 Mar;26(2):161-71. Unique Identifier : AIDSLINE MED/95328859; Mikola H; Waris M; Tenovuo J; Department of Cariology, University of Turku, Finland.; The human mouth is an important route of viral transmission and evidence exists that human saliva can neutralize some viruses, e.g. herpes simplex type 1 (HSV-1) and human immunodeficiency virus (HIV) in vitro. However, little is known of the actual antiviral agents in saliva. We have analyzed how hypothiocyanite (HOS
Effect of lithium in immunodeficiency: improved blood cell formation in mice with decreased hematopoiesis as the result of LP-BM5 MuLV infection.: Antiviral Res. 1995 Mar;26(2):189-202. Unique Identifier : AIDSLINE MED/95328861; Gallicchio VS; Hughes NK; Tse KF; Ling J; Birch NJ; Hematology/Oncology Division Chandler Medical Center, University; of Kentucky, L.P. Markey Cancer Center, Lexington 40536-0084,; USA.; Lithium salts have been demonstrated to induce the production of hematopoietic cells following administration in vivo and to minimize the reduction of these cells following treatment with either radiation, chemotherapeutic or antiviral drugs. We have previously demonstrated that lithium, when administered in vivo to i
Distribution of CD4+ T lymphocytes at diagnosis of acquired immunodeficiency syndrome-defining and other human immunodeficiency virus-related illnesses. The Adult and Adolescent Spectrum of HIV Disease Project Group.: Arch Intern Med. 1995 Jul 24;155(14):1537-42. Unique Identifier : AIDSLINE MED/95328903; Hanson DL; Chu SY; Farizo KM; Ward JW; Division of HIV/AIDS, Centers for Disease Control, Atlanta, Ga.,; USA.; BACKGROUND: Depletion of circulating CD4+ T lymphocytes among persons infected with the human immunodeficiency virus (HIV) is associated with increased risk for development of opportunistic, life-threatening diseases and death. METHODS: To describe the levels of CD4+ T lymphocytes at which acquired immunodeficiency sy
Links and interactions between mycoplasmas and viruses: past confusions and present realities.: Arch Virol. 1995;140(5):811-26. Unique Identifier : AIDSLINE MED/95328944; Chastel C; Virus Laboratory, Faculty of Medicine, Brest, France.; Links between mycoplasmas and viruses are ancient, multiple and complex, from past confusions during the first decades of the virus era to present realities illustrated by the possible implication of mycoplasmas as co-factors in natural infections of AIDS. Mycoplasma viruses (phages) may also be responsible for modify
HIV-1 DNA in fibroblast cultures infected with urine from HIV-seropositive cytomegalovirus (CMV) excretors.: Arch Virol. 1995;140(5):927-35. Unique Identifier : AIDSLINE MED/95328952; Margalith M; D'Aquila RT; Manion DJ; Basgoz N; Bechtel LJ; Smith BR; Kaplan JC; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston, USA.; Interactions between HIV-1 and CMV may be important in the pathogenesis of AIDS. We have studied whether active CMV infection alters the cell tropism of HIV-1 in dually-infected individuals. Urines from HIV-seropositive individuals excreting CMV were compared to
Antibody to ICAM-1 mediates enhancement of HIV-1 infection of human endothelial cells.: Arch Virol. 1995;140(5):951-8. Unique Identifier : AIDSLINE MED/95328955; Scheglovitova O; Scanio V; Fais S; Papadia S; Abbate I; Castilletti C; Dianzani F; Capobianchi MR; Gamaleya Institute for Microbiology and Epidemiology, Moscow,; Russia.; Human umbilical vein endothelial cells (HUVEC) can be abortively infected with HIV-1, but virus production is rescued by the addition of T cells. Monoclonal antibody (Mab) to ICAM-1, but not its Fab fragment or MAbs to LFA-1 and PECAM-1, increases HIV-1 infection of HUVEC by enhancing HIV-1 absorption. Enhancement by
The role of bronchoscopy in the diagnosis and treatment of pulmonary disease in HIV-infected patients.: Aust N Z J Med. 1995 Apr;25(2):133-9. Unique Identifier : AIDSLINE MED/95329049; Lewin SR; Hoy J; Crowe SM; McDonald CF; Fairfield Hospital, Melbourne, Vic.; BACKGROUND: Pulmonary disease is the most common reason for presentation and the major cause of death in HIV-infected patients. There has been an evolution in the optimal approach to the investigation of a pulmonary infiltrate in HIV-infected patients since the introduction of induced sputum for the diagnosis of Pneum
Severe accidental dapsone overdose.: Am J Emerg Med. 1995 Jul;13(4):414-5. Unique Identifier : AIDSLINE MED/95329157; McGoldrick MD; Bailie GR; Albany Medical College, NY, USA.; Acute poisoning from excessive dapsone (4,4-diaminodiphenylsulfone) intake in uncommon in the United States ; no cases were reported during 1992. However, with the increasing use of dapsone for diseases other than leprosy and dermatitis herpetiformis, such as acne vulgaris, psoriasis, a
[Granulomatous angiitis of the central nervous system complicated by the syndrome of inappropriate antidiuretic hormone]: No To Shinkei. 1995 Jun;47(6):595-9. Unique Identifier : AIDSLINE MED/95329363; Shiozi Y; Takeshima M; Itoshima T; Nose S; Hamaya K; Department of Internal Medicine, Okayama Saiseikai General; Hospital, Japan.; We report an autopsy case of granulomatous angiitis of the central nervous system (GANS) complicated by the syndrome of inappropriate antidiuretic hormone (SIADH). A 88-year old female was admitted because of progressive mental deterioration, fever, and vomiting. A computed tomogram disclosed bilateral periventricular
Murder and cover up could explain the Florida AIDS mystery [letter]: Br Dent J. 1995 Jun 24;178(12):446-7. Unique Identifier : AIDSLINE MED/95329389; Lewis DL
Murder and cover up could explain the Florida AIDS mystery [letter; comment]: Br Dent J. 1995 Jun 24;178(12):446: discussion 447. Unique Identifier : AIDSLINE MED/95329390; Thorogood N; Newton JT
Going blind.: Am J Hosp Palliat Care. 1995 May-Jun;12(3):31-5. Unique Identifier : AIDSLINE MED/95329414; Seyfrit M
The amino-terminal peptide of HIV-1 glycoprotein 41 fuses human erythrocytes.: Biochim Biophys Acta. 1995 Jun 9;1271(2-3):304-14. Unique Identifier : AIDSLINE MED/95329485; Mobley PW; Lee HF; Curtain CC; Kirkpatrick A; Waring AJ; Gordon LM; Chemistry Department, California State Polytechnic University,; Pomona, USA.; The ability of synthetic peptides based on the amino-terminus of HIV-1 glycoprotein 41,000 (gp41) to fuse human erythrocytes was investigated. Previous site-directed mutagenesis studies have shown an important role for the N-terminal gp41 domain in HIV-fusion, in which replacement of hydrophobic amino acids with polar
Depletion of CD4+ and CD8+ cells eliminates immunologic memory of thyroiditogenicity in murine experimental autoimmune thyroiditis.: Autoimmunity. 1994;19(3):161-8. Unique Identifier : AIDSLINE MED/95329563; Fuller BE; Giraldo AA; Waldmann H; Cobbold SP; Kong YC; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201, USA.; Experimental autoimmune thyroiditis (EAT) develops in genetically susceptible mice after immunization with mouse thyroglobulin (MTg), and is mediated by T cells, both CD4+ and CD8+, infiltrating the thyroid. Previous work showed that depletion of CD4+, but not CD8+, cells with rat monoclonal antibodies (mAbs) interfer
Hepatitis C virus challenges AIDS associated viruses at the transfusion crossings: the place and time for a second trial [editorial]: Biomed Pharmacother. 1995;49(2):53-4. Unique Identifier : AIDSLINE MED/95329608; Mathe G
Transmission of hepatitis C virus from mothers to infants: its frequency and risk factors revisited.: Biomed Pharmacother. 1995;49(2):59-64. Unique Identifier : AIDSLINE MED/95329610; Moriya T; Sasaki F; Mizui M; Ohno N; Mohri H; Mishiro S; Yoshizawa H; Department of Hygiene, Hiroshima University School of Medicine,; Japan.; A total of 16,714 pregnant Japanese women were tested for antibodies against hepatitis C virus (HCV), and 163 (0.98%) were positive. None of these were infected with human immunodeficiency virus-1 (HIV-1). We conducted a prospective study to discover the rate of HCV infection in babies born to mothers who were HCV RNA
High expression of latent membrane protein 1 of Epstein-Barr virus and BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas.: Blood. 1995 Jul 15;86(2):432-5. Unique Identifier : AIDSLINE MED/95329697; Camilleri-Broet S; Davi F; Feuillard J; Bourgeois C; Seilhean D; Hauw JJ; Raphael M; Departement de Neuropathologie INSERM U360, CHU; Pitie-Salpetriere, Paris, France.; Nearly all primary brain lymphomas in acquired immunodeficiency syndrome (AIDS) patients are associated withEpstein-Barr virus (EBV). The role of EBV in lymphomagenesis is not totally elucidated. One possible mechanism is the overexpression of the BCL-2 oncoprotein, because the latent membrane protein 1 (LMP1) has bee
Iodine-mediated inactivation of lipid- and nonlipid-enveloped viruses in human antithrombin III concentrate.: Blood. 1995 Jul 15;86(2):791-6. Unique Identifier : AIDSLINE MED/95329739; Highsmith F; Xue H; Chen X; Benade L; Owens J; Shanbrom E; Drohan W; Holland Laboratory, Plasma Derivatives Department, American Red; Cross, Rockville, MD 20855, USA.; Human plasma-derived protein concentrates intended for clinical use must be treated for viral inactivation to ensure patient safety. This study explored the use of liquid iodine for inactivation of several lipid- and nonlipid-enveloped viruses in an antithrombin III (AT-III) concentrate. Iodine at levels of 0.01% to 0
A model for HIV in Asia.: Math Biosci. 1995 Jul-Aug;128(1-2):185-210. Unique Identifier : AIDSLINE MED/95329892; Busenberg S; Cooke K; Hsieh YH; Mathematics Department, Harvey Mudd College, Claremont,; California, USA.; A model is proposed in which the spread of HIV/AIDS in the community is mainly due to the sexual interaction between a core group of female prostitutes and young unmarried males. Several threshold parameters are obtained that determine persistence of endemic proportions, persistence of total population, and the persis
The impact of sexual mixing patterns on the spread of AIDS.: Math Biosci. 1995 Jul-Aug;128(1-2):211-41. Unique Identifier : AIDSLINE MED/95329893; Kault DA; Anton Breinl Centre for Tropical Health and Medicine, James Cook; University, Townsville, Queensland, Australia.; It has previously been demonstrated that the distribution of sexual partner change rates may not be sufficient behavioral information to predict the spread of AIDS. A more adequate description of the sexual network through which AIDS may spread will require information on who mixes with whom. Previous models indicated
Histologic patterns of basal cell carcinoma based upon patient immunostatus.: Dermatol Surg. 1995 Jul;21(7):611-4. Unique Identifier : AIDSLINE MED/95330248; Oram Y; Orengo I; Griego RD; Rosen T; Thornby J; Department of Dermatology, VA Medical Center, Houston, Texas,; USA.; BACKGROUND. The biologic behavior of basal cell carcinoma (BCC) seems to be dictated by the histologic subtype. Moreover, BCCs in immunosuppressed patients appear to show a more aggressive biologic behavior. OBJECTIVE. The purpose of this study was to retrospectively investigate different histologic subtypes of BCC to
Synthesis of peptide analogues containing phosphonamidate methyl ester functionality: HIV-1 proteinase inhibitors possessing unique cell uptake properties.: Bioorg Med Chem. 1995 Mar;3(3):297-12. Unique Identifier : AIDSLINE MED/95330267; Camp NP; Perrey DA; Kinchington D; Hawkins PC; Gani D; School of Chemistry, The University, St. Andrews, Fife, U.K.; Stereochemically defined and epimeric phosphonamidate methyl ester-containing peptide analogues were synthesised and were found to be moderate inhibitors of the HIV-1 proteinase. All of the analogues containing the phosphonamidate ester grouping showed a marked ability to enter cells, as highlighted by the approximate
Health beliefs and discontinuation of zidovudine therapy.: Am J Health Syst Pharm. 1995 Mar 1;52(5):505-7. Unique Identifier : AIDSLINE MED/95330544; Geletko SM; Ballard CR; Mathews WC; College of Pharmacy, University of Rhode Island, Kingston, USA.
Role of interleukin-2 in managing infection with the human immunodeficiency virus.: Am J Health Syst Pharm. 1995 Mar 1;52(5):541-2. Unique Identifier : AIDSLINE MED/95330553; Piscitelli SC; Minor JR; Pharmacy Department, Warren G. Magnuson Clinical Center, National; Institutes of Health, Bethesda, MD 20892, USA.
Age-related differences in subset composition and activation responses of intestinal intraepithelial and mesenteric lymph node lymphocytes from neonatal swine.: Cell Immunol. 1995 Jul;163(2):215-21. Unique Identifier : AIDSLINE MED/95330821; Whary MT; Zarkower A; Confer FL; Ferguson FG; Department of Veterinary Science, College of Agricultural; Sciences, Pennsylvania State University, University Park 16802,; USA.; Interesting differences were found in the phenotypes and functional responses of intestinal intraepithelial lymphocytes (IEL) and mesenteric lymph node lymphocytes (MLN) from neonatal swine aged 15 to 47 days. IEL and MLN differed significantly in their proliferative responses to the mitogens concanavalin A (Con A) an
Expression and biological activities of bovine interleukin 4: effects of recombinant bovine interleukin 4 on T cell proliferation and B cell differentiation and proliferation in vitro.: Cell Immunol. 1995 Jul;163(2):268-79. Unique Identifier : AIDSLINE MED/95330828; Estes DM; Hirano A; Heussler VT; Dobbelaere DA; Brown WC; Department of Veterinary Microbiology, College of Veterinary; Medicine, University of Missouri, Columbia 65211, USA.; Interleukin 4 (IL-4) is a pleotropic cytokine affecting a wide range of cell types in both the mouse and the human. These activities include regulation of the growth and differentiation of both T and B lymphocytes. The activities of IL-4 in nonprimate, nonmurine systems are not well established. Herein, we demonstrate
Th1 and Th2 cells in autoimmunity.: Clin Exp Immunol. 1995 Jul;101 Suppl 1:9-12. Unique Identifier : AIDSLINE MED/95330898; Druet P; Sheela R; Pelletier L; INSERM U28, Hopital de Purpan, Universite Paul Sabatier,; Toulouse, France.
CD40 ligand expression is developmentally regulated in human thymocytes.: Clin Immunol Immunopathol. 1995 Jul;76(1 Pt 1):52-8. Unique Identifier : AIDSLINE MED/95330906; Fuleihan R; Ahern D; Geha RS; Division of Immunology, Children's Hospital, Boston,; Massachusetts 02115, USA.; Thymic selection involves the interaction between developing thymocytes and the thymic microenvironment. CD40 is expressed on thymic epithelial cells and on bone marrow-derived antigen-presenting cells in the thymus. We have investigated the capacity of human thymocytes to express CD40 ligand. CD40 ligand was not dete
Increase of activated T-cells in BAL fluid of Japanese patients with bronchiolitis obliterans organizing pneumonia and chronic eosinophilic pneumonia.: Chest. 1995 Jul;108(1):123-8. Unique Identifier : AIDSLINE MED/95330989; Mukae H; Kadota J; Kohno S; Matsukura S; Hara K; Third Department of Internal Medicine, Miyazaki Medical College,; Japan.; To study the role of T cells in bronchiolitis obliterans organizing pneumonia (BOOP) and chronic eosinophilic pneumonia (CEP) and to examine the influence of differing racial background, T-cell subsets in bronchoalveolar lavage (BAL) fluid (BALF) and in peripheral blood of 8 Japanese patients with idiopathic BOOP and
Eosinophil activation in patients with pulmonary fibrosis.: Chest. 1995 Jul;108(1):48-54. Unique Identifier : AIDSLINE MED/95331038; Fujimoto K; Kubo K; Yamaguchi S; Honda T; Matsuzawa Y; First Department of Internal Medicine, Shinshu University School; of Medicine, Matsumoto, Japan.; The eosinophil count and concentrations of eosinophil cationic protein (ECP) were measured in bronchoalveolar lavage fluid (BALF) from patients with idiopathic pulmonary fibrosis (IPF), pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), sarcoidosis, and healthy controls. The patients with IPF an
Respiratory diseases in Rwanda [editorial]: Chest. 1995 Jul;108(1):5-7. Unique Identifier : AIDSLINE MED/95331039; Prakash UB
Immunologic aspects of vigabatrin treatment in epileptic children.: Epilepsia. 1995 Apr;36(4):423-6. Unique Identifier : AIDSLINE MED/95331173; Pacifici R; Zuccaro P; Iannetti P; Raucci U; Imperato C; Clinical Biochemistry Department, Istituto Superiore di Sanita,; Rome, Italy.; Vigabatrin (VGB) is an antiepileptic drug (AED) that acts by irreversibly inhibiting gamma-aminobutyric acid transaminase (GABA-T). To evaluate immune responses to GVG, we studied 29 idiopathic or symptomatic epileptic children and also examined a control group (n = 15). Epileptic children were tested before and after
Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme.: Environ Health Perspect. 1995 Apr;103(4):366-71. Unique Identifier : AIDSLINE GENBANK; Yao Y; Hoffer A; Chang CY; Puga A; Center for Environmental Genetics, University of Cincinnati; Medical Center, OH 45267-0056, USA.; We have studied the effect of several environmental chemicals on the transient expression of a chloramphenicol acetyltransferase (cat) reporter gene linked to the promoter sequences in the long terminal repeat (LTR) of the human immunodeficiency virus type 1 (HIV-1). Aflatoxin B1, 2,3,7,8-tetrachlorodibenzo-p-dioxin (
Effect of nutritional and HIV status on bacteraemia in Zimbabwean children who died at home.: Eur J Pediatr. 1995 Apr;154(4):299-303. Unique Identifier : AIDSLINE MED/95331348; Wolf BH; Ikeogu MO; Vos ET; Department of Paediatrics, Mpilo Central Hospital, Bulawayo,; Zimbabwe.; From July 1992 to May 1993 a study was performed of the relationship between bacteraemia, nutritional status and HIV status in 212 out of 334 consecutive infants and children aged 0-5 years, who had died at home in Bulawayo, Zimbabwe . The remaining 122 children were excluded beca
Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and V3 loop-derived peptides from several strains of HIV-1.: FEBS Lett. 1995 Jul 3;367(3):251-6. Unique Identifier : AIDSLINE MED/95331385; Avril LE; di Martino-Ferrer M; Brillard-Bourdet M; Gauthier F; Laboratory of Enzymology and Protein Chemistry, CNRS URA 1334,; University Francois Rabelais, Tours, France.; A cell surface-associated cathepsin G has been reported to be a possible complementary factor for HIV-1 infection of U-937 cells. The effect of recombinant gp120 (IIIB) and a series of V3 loop peptides derived from the sequence of different strains of HIV on the activity of U-937 cathepsin G was assayed. The sequence
The trans-inhibitory Rep78 protein of adeno-associated virus binds to TAR region DNA of the human immunodeficiency virus type 1 long terminal repeat.: FEBS Lett. 1995 Jul 3;367(3):267-71. Unique Identifier : AIDSLINE MED/95331388; Batchu RB; Hermonat PL; Department of Obstetrics and Gynecology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; The large rep gene products, Rep78 and Rep68, of adeno-associated virus (AAV) are pleiotropic effector proteins which are required for AAV DNA replication and the trans-regulation of AAV gene expression. Apart from these essential functions prerequisite for the life cycle of AAV, these rep products are able to inhibit
[Repeated passive immunotherapy delays AIDS progression (news)]: Fortschr Med. 1995 May 20;113(14):13. Unique Identifier : AIDSLINE MED/95331666; Paris KA
[Rate of HIV infection in the French army is still relatively low (news)]: Fortschr Med. 1995 May 30;113(15):12. Unique Identifier : AIDSLINE MED/95331674
Pathogenesis of HIV-1 disease.: Int J Dermatol. 1995 May;34(5):308-18. Unique Identifier : AIDSLINE MED/95331917; Smith KJ; Skelton HG; Wagner KF; Walter Reed Army Institute of Research, Washington, District of; Columbia, USA.
Identification of transcriptional activation domain of TREB5, a CREB/ATF family protein that binds to HTLV-1 enhancer.: J Biochem (Tokyo). 1995 Feb;117(2):303-8. Unique Identifier : AIDSLINE MED/95332251; Matsuzaki Y; Fujisawa J; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo.; TREB5 (hXBP-1) protein is a transcription factor that recognizes the CRE-like element in enhancers of human T-cell leukemia virus and MHC class II gene and activates their transcription. TREB5 is a member of the CREB/ATF family, containing a basic amino acid region and leucine zipper structure (b-Zip structure). To ch
Reaction time slowing in HIV-1-infected individuals: role of the preparatory interval.: J Clin Exp Neuropsychol. 1995 Feb;17(1):122-33. Unique Identifier : AIDSLINE MED/95332446; Law WA; Mapou RL; Roller TL; Martin A; Nannis ED; Temoshok LR; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland, USA.; Psychomotor speed and directed attention were evaluated in 83 human immunodeficiency virus-1-infected individuals (HIV+) and 50 HIV-1 seronegative (HIV-) control participants using simple and choice reaction time (RT) tasks. The simple RT task included 1- and 3-s, irregularly varied preparatory intervals (PI) between
Qualitative features of the memory deficit associated with HIV infection and AIDS: cross-validation of a discriminant function classification scheme.: J Clin Exp Neuropsychol. 1995 Feb;17(1):134-42. Unique Identifier : AIDSLINE MED/95332447; Becker JT; Caldararo R; Lopez OL; Dew MA; Dorst SK; Banks G; Department of Psychiatry, University of Pittsburgh School of; Medicine, USA.; The neuropsychological defects associated with late stage HIV infection and AIDS have been characterized as being similar to those seen in patients with dementia syndromes of subcortical etiologies. The purpose of this paper is to report on the cross-center replication of the class
Women's self-disclosure of HIV infection: rates, reasons, and reactions.: J Consult Clin Psychol. 1995 Jun;63(3):474-8. Unique Identifier : AIDSLINE MED/95332520; Simoni JM; Mason HR; Marks G; Ruiz MS; Reed D; Richardson JL; Department of Preventive Medicine, University of Southern; California, Los Angeles 90033-1042, USA.; A survey of 65 ethnically diverse women at 2 outpatient HIV clinics revealed relatively low rates of disclosure of HIV-positive serostatus to extended family members, somewhat higher rates for immediate family members, and highest rates for lovers and friends. Spanish-speaking Latinas were less likely to disclose thei
College health responds to HIV: hard lessons and a rich heritage.: J Am Coll Health. 1995 May;43(6):271-2. Unique Identifier : AIDSLINE MED/95332587; Keeling RP; University health services, University of Wisconsin, Madison,; USA.
Evaluation of infection control measures in preventing the nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in a New York City hospital.: Infect Control Hosp Epidemiol. 1995 Mar;16(3):141-7. Unique Identifier : AIDSLINE MED/95332673; Stroud LA; Tokars JI; Grieco MH; Crawford JT; Culver DH; Edlin BR; Sordillo EM; Woodley CL; Gilligan ME; Schneider N; et al; Hospital Infections Program, Centers for Disease Control,; Atlanta, GA 30033, USA.; OBJECTIVE: To evaluate the efficacy of Centers for Disease Control and Prevention (CDC)-recommended infection control measures implemented in response to an outbreak of multidrug-resistant (MDR) tuberculosis (TB). DESIGN: Retrospective cohort studies of acquired immunodeficiency syndrome (AIDS) patients and healthcare
FDA approves oral HIV test [news]: Infect Control Hosp Epidemiol. 1995 Mar;16(3):186. Unique Identifier : AIDSLINE MED/95332681
Chimeric zeta-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes.: J Immunol. 1995 Jul 15;155(2):1000-9. Unique Identifier : AIDSLINE MED/95332705; Tran AC; Zhang D; Byrn R; Roberts MR; Cell Genesys, Foster City, CA 94404, USA.; Chimeric receptors in which a signaling component of the TCR complex such as zeta is fused directly to the ligand binding domain of a heterologous receptor or Ab have been shown to redirect the specific effector activity of T lymphocytes. We previously described the ability of two classes of such chimeric zeta-recepto
Interference with thymocyte differentiation by an inhibitor of S-adenosylhomocysteine hydrolase.: J Immunol. 1995 Jul 15;155(2):536-44. Unique Identifier : AIDSLINE MED/95332709; Benveniste P; Zhu W; Cohen A; Division of Immunology and Cancer Research, Hospital for Sick; Children, Toronto, Ontario, Canada.; Adenosine deaminase (ADA) deficiency causes severe combined immune-deficiency disease in humans. It is believed that the accumulation of the ADA substrate deoxyadenosine affects T cell development through interference with deoxynucleotide metabolism and/or S-adenosylmethionine-mediated methylation processes. In this s
A novel cell surface antigen, immature thymocyte antigen-1, is involved in the differentiation of murine thymocytes.: J Immunol. 1995 Jul 15;155(2):568-77. Unique Identifier : AIDSLINE MED/95332712; Kishi H; Su DM; Muraguchi A; Watanabe T; Department of Immunology, Faculty of Medicine, Toyama Medical and; Pharmaceutical University, Japan.; A mAb, 1-23, which recognizes a novel cell surface Ag on immature murine thymocytes (designated as IMT-1 for immature thymocyte antigen-1) was prepared. IMT-1 was found to be expressed on 40 to 50% of CD4-8- double negative (DN), 5 to 10% of CD4-8+, and 5 to 20% of CD4+8+ double positive (DP) thymocytes in adult mice,
Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.: J Immunol. 1995 Jul 15;155(2):585-93. Unique Identifier : AIDSLINE MED/95332714; Krenger W; Snyder KM; Byon JC; Falzarano G; Ferrara JL; Division of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, MA 02115, USA.; Acute graft-vs-host disease (GVHD) is thought to be mediated by alloreactive T cells with a type 1 cytokine phenotype. To prevent the development of acute GVHD, we have successfully polarized mature donor T cells toward a type 2 cytokine phenotype ex-vivo by incubating them with murine rIL-4 in a primary MLC. Polarize
Transforming growth factor beta 1 costimulated growth and regulatory function of staphylococcal enterotoxin B-responsive CD8+ T cells.: J Immunol. 1995 Jul 15;155(2):609-18. Unique Identifier : AIDSLINE MED/95332717; Rich S; Seelig M; Lee HM; Lin J; Department of Microbiology and Immunology, Baylor College of; Medicine, Houston, TX 77030, USA.; Transforming growth factor beta (TGF-beta) exhibits diverse effects on growth and differentiation of a wide range of cell types. In the immune system, TGF-beta 1 is a potent inhibitor of T cell proliferation and certain T cell effector functions. However, TGF-beta 1 also enhances growth of T cells, predominantly of na
Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.: J Immunol. 1995 Jul 15;155(2):730-9. Unique Identifier : AIDSLINE MED/95332730; Heinzel FP; Rerko RM; Ahmed F; Pearlman E; Division of Geographic Medicine, Case Western Reserve University; School of Medicine, Cleveland, OH 44106, USA.; We investigated the mechanisms by which treatment with anti-IL-12 Ab prevents cure of infection with Leishmania major in resistant C57BL/6 mice. Consistent with delayed production of IL-12, anti-IL-12 Abs could be administered as late as 2 wk after infection to exacerbate disease. Starting at 2 wk of infection, the cu
Rapid development of murine AIDS is dependent of signals provided by CD54 and CD11a.: J Immunol. 1995 Jul 15;155(2):974-81. Unique Identifier : AIDSLINE MED/95332757; Makino M; Yoshimatsu K; Azuma M; Okada Y; Hitoshi Y; Yagita H; Takatsu K; Komuro K; Department of Bacterial and Blood Products, National Institute of; Health Japan, Tokyo.; Murine AIDS (MAIDS) is induced by infection with the replication-defective virus (BM5def) component in the LP-BM5 murine leukemia virus (MuLV) mixture. The disease is characterized by polyclonally activated CD4+ T cells and B cells. It is known that BM5def is expressed at highest levels in B lymphocytes and that B cel
A case of protracted coxsackie virus meningoencephalitis in a marginally immunodeficient child treated successfully with intravenous immunoglobulin.: J Neurol Sci. 1995 Apr;129(2):131-3. Unique Identifier : AIDSLINE MED/95332914; Geller TJ; Condie D; M.D. Department of Neurology, St. Louis University School of; Medicine, MO 63110, USA.; A child with acute lymphocytic leukemia who was in clinical remission and developed coxsackie B4 meningoencephalitis is presented. Despite minimal evidence of immunodeficiency, the patient had progression of neurologic disease clinically, electroencephalographically and on laboratory evaluation of spinal fluid. A dram
Progression of neurological disability in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).: J Neurol Sci. 1995 Apr;129(2):147-51. Unique Identifier : AIDSLINE MED/95332917; Araujo AQ; Leite AC; Dultra SV; Andrada-Serpa MJ; HTLV-Associated Neuropathies Research Unit, IOC, Hospital Evandro; Chagas, FIOCRUZ, Rio de Janeiro, Brazil.; HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is apparently a disease with a chronic evolution without spontaneous remissions. The real profile of its natural history and of the progression of the neurological disability, however, awaits confirmation. We devised the present study to evaluate the
Flexible ligand docking using a genetic algorithm.: J Comput Aided Mol Des. 1995 Apr;9(2):113-30. Unique Identifier : AIDSLINE MED/95332931; Oshiro CM; Kuntz ID; Dixon JS; Department of Pharmaceutical Chemistry, School of Pharmacy,; University of California, San Francisco 94143-0446, USA.; Two computational techniques have been developed to explore the orientational and conformational space of a flexible ligand within an enzyme. Both methods use the Genetic Algorithm (GA) to generate conformationally flexible ligands in conjunction with algorithms from the DOCK suite of programs to characterize the rece
Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus.: J Pediatr. 1995 Jul;127(1):137-46. Unique Identifier : AIDSLINE MED/95333000; Domanski MJ; Sloas MM; Follmann DA; Scalise PP 3rd; Tucker EE; Egan D; Pizzo PA; Cardiology Branch, National Heart, Lung, and Blood Institute,; Bethesda, MD 20892, USA.; OBJECTIVES: Human immunodeficiency virus (HIV) infection in children can be complicated by the development of cardiac disease. Decreased left ventricular function has been temporally associated with the use of zidovudine (azidothymidine; AZT ) in adult
The epidemiology of rotavirus infections: a global perspective.: J Pediatr Gastroenterol Nutr. 1995 Apr;20(3):275-86. Unique Identifier : AIDSLINE MED/95333022; Haffejee IE; Department of Paediatrics & Child Health, Faculty of Medicine,; University of Natal, Durban, South Africa.; Rotavirus, which is the most common cause of infantile diarrhea worldwide, mainly affects infants between the ages of 6 and 24 months. Most infections in human newborns are mild or asymptomatic, due to the inherently attenuated nature of the nursery rotavirus strains. Adults are also sometimes affected, especially tho
Hepatic toxicity associated with 2'-3' dideoxyinosine in children with AIDS.: J Pediatr Gastroenterol Nutr. 1995 Apr;20(3):287-90. Unique Identifier : AIDSLINE MED/95333023; Lacaille F; Ortigao MB; Debre M; Rouzioux C; Brousse N; Blanche S; Department of Pediatrics, Necker Enfants-Malades Hospital, Paris,; France.; Among 34 children with AIDS enrolled in a trial with 2 -3 dideoxyinosine (ddI), six (aged 1-6 years) developed liver abnormalities within 2-18 months after institution of ddI. Two children died of fulminant hepatic failure (one had also an adenovirus infection), and four had a striking elevation of alkaline phosphata
Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine.: J Med Chem. 1995 Jun 23;38(13):2317-25. Unique Identifier : AIDSLINE MED/95333099; Nunn CM; Neidle S; CRC Biomolecular Structure Unit, Institute of Cancer Research,; Sutton, Surrey, U.K.; The DNA-binding ligand propamidine, an analogue of the drug pentamidine which is used in the treatment of acquired immune deficiency syndrome (AIDS)-associated Pneumocystis carinii, has been cocrystallized with the DNA sequence d(CGCAAATTTGCG)2, and the crystal structure of the complex has been determined using data f
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.: J Med Chem. 1995 Jun 23;38(13):2349-56. Unique Identifier : AIDSLINE MED/95333103; Asano N; Kizu H; Oseki K; Tomioka E; Matsui K; Okamoto M; Baba M; Faculty of Pharmaceutical Sciences, Hokuriku University,; Kanazawa, Japan.; The conformations of nitrogen-in-the-ring sugars and their N-alkyl derivatives were studied from 1H NMR analyses, mainly using 3J(H,H) coupling constants and quantitative NOE experiments. No significant difference was seen in the ring conformation of 1-deoxynojirimycin (1), N-methyl-1-deoxynojirimycin (2), and N-butyl
Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds.: J Med Chem. 1995 Jun 23;38(13):2427-32. Unique Identifier : AIDSLINE MED/95333109; Royer RE; Deck LM; Vander Jagt TJ; Martinez FJ; Mills RG; Young SA; Vander Jagt DL; Department of Biochemistry, University of New Mexico School of; Medicine, Albuquerque 87131, USA.; 1,1 -Dideoxygossypol (DDG), 1,1 -dideoxygossylic acid (DDGA), 8-deoxyhemigossypol (DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested for their ability to inhibit the replication of HIV in vitro. The EC50 for DDGA was
Polyanion inhibitors of human immunodeficiency virus and other viruses. 1. Polymerized anionic surfactants.: J Med Chem. 1995 Jun 23;38(13):2433-40. Unique Identifier : AIDSLINE MED/95333110; Leydet A; Barthelemy P; Boyer B; Lamaty G; Roque JP; Bousseau A; Evers M; Henin Y; Snoeck R; Andrei G; et al; Laboratoire de Chimie Organique Physique, Universite Montpellier; II, France.; A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses. Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, proved active against HIV-1 within the concentration range of 0.1-3 microg
Quo vadis antiviral agents for herpes, influenza and HIV? [editorial]: J Med Microbiol. 1995 Jul;43(1):1-3. Unique Identifier : AIDSLINE MED/95333154; Oxford JS
Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.: J Mol Biol. 1995 Jul 7;250(2):169-80. Unique Identifier : AIDSLINE MED/95333174; Veschambre P; Simard P; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale; Superieure de Lyon, UMR49 CNRS, France.; Tat strongly activates transcription of the HIV-1 provirus by stimulating both initiation and elongation. This transactivator binds to the TAR RNA element, but can also associate with cellular transcription factors, interacting with upstream promoter sequences. To achieve a better understanding of the role of Tat in t
Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand.: J Virol. 1995 Aug;69(8):4649-55. Unique Identifier : AIDSLINE +; Yu XF; Wang Z; Beyrer C; Celentano DD; Khamboonruang C; Allen E; Nelson K; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.; Primary human immunodeficiency virus type 1 (HIV-1) isolates were obtained from 22 patients with AIDS from northern Thailand , where HIV-1 is transmitted primarily through the heterosexual route. Viral sequences were determined for the 22 patients with AIDS, and all were subtype E
Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.: J Virol. 1995 Aug;69(8):4656-67. Unique Identifier : AIDSLINE MED/95333240; Hibbard MK; Sandri-Goldin RM; Department of Microbiology and Molecular Genetics, College of; Medicine, University of California, Irvine 92717-4025, USA.; The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein that localizes to the nuclei of infected cells. The strong nuclear localization signal (NLS) of ICP27 was identified recently and shown to reside in the amino-terminal portion of the polypeptide from residues 110 t
Analysis of the cleavage site of the human immunodeficiency virus type 1 glycoprotein: requirement of precursor cleavage for glycoprotein incorporation.: J Virol. 1995 Aug;69(8):4675-82. Unique Identifier : AIDSLINE MED/95333242; Dubay JW; Dubay SR; Shin HJ; Hunter E; Department of Microbiology, University of Alabama at Birmingham; 35294, USA.; Endoproteolytic cleavage of the glycoprotein precursor to the mature SU and TM proteins is an essential step in the maturation of retroviral glycoproteins. Cleavage of the precursor polyprotein occurs at a conserved, basic tetrapeptide sequence and is carried out by a cellular protease. The glycoprotein of the human i
Vaccination with recombinant vaccinia viruses expressing ICP27 induces protective immunity against herpes simplex virus through CD4+ Th1+ T cells.: J Virol. 1995 Aug;69(8):4711-6. Unique Identifier : AIDSLINE MED/95333246; Manickan E; Francotte M; Kuklin N; Dewerchin M; Molitor C; Gheysen D; Slaoui M; Rouse BT; Department of Microbiology, College of Veterinary Medicine,; University of Tennessee, Knoxville 37996-0845, USA.; This study was designed to evaluate the efficacy and mechanisms of protection mediated by recombinant vaccinia viruses encoding immediate-early (IE) proteins of herpes simplex virus type 2 (HSV-2). Three mouse strains were immunized against the IE proteins ICP27, ICP0, and ICP4, and mice were challenged intracutaneous
Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients.: J Virol. 1995 Aug;69(8):4737-45. Unique Identifier : AIDSLINE MED/95333249; McIlroy D; Autran B; Cheynier R; Wain-Hobson S; Clauvel JP; Oksenhendler E; Debre P; Hosmalin A; Laboratoire d'Immunologie Cellulaire et Tissulaire, URA CNRS 625,; Hopital de La Pitie-Salpetriere, Paris, France.; Dendritic cells (DC) are specialized antigen-presenting leukocytes that are responsible for the activation of naive as well as memory T lymphocytes. If infected by human immunodeficiency virus (HIV), DC may transfer virus to CD4+ lymphocytes. However, the question of whether DC are infected in vivo is controversial. A
A single mutation within the V3 envelope neutralization domain of feline immunodeficiency virus determines its tropism for CRFK cells.: J Virol. 1995 Aug;69(8):4752-7. Unique Identifier : AIDSLINE MED/95333251; Verschoor EJ; Boven LA; Blaak H; van Vliet AL; Horzinek MC; de Ronde A; Institute of Infectious Diseases and Immunology, University; Utrecht, The Netherlands.; Feline immunodeficiency virus (FIV) isolates differ in the ability to replicate in Crandell feline kidney (CRFK) cells. The difference in tropism between two variants of the Dutch isolate FIV-UT113 was studied by using molecular clones which contained the envelope genes of the variants in a background of the FIV-14 Pe
vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys.: J Virol. 1995 Aug;69(8):4807-13. Unique Identifier : AIDSLINE MED/95333258; Hoch J; Lang SM; Weeger M; Stahl-Hennig C; Coulibaly C; Dittmer U; Hunsmann G; Fuchs D; Muller J; Sopper S; et al; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany.; In previous experiments, animals infected with SIVmac239 containing a point mutation in the vpr and nef genes developed AIDS-like symptoms after early reversion of the vpr and nef genes. Here we show that two animals in which the nef gene but not the vpr gene had reverted in the first few months did not develop diseas
The peri-kappa B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells.: J Virol. 1995 Aug;69(8):4854-62. Unique Identifier : AIDSLINE MED/95333264; Clark NM; Hannibal MC; Markovitz DM; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0642, USA.; Human immunodeficiency virus type 2 (HIV-2), like HIV-1, causes AIDS and is associated with AIDS cases primarily in West Africa. HIV-1 and HIV-2 display significant differences in nucleic acid sequence and in the natural history of clinical disease. Consistent with these differences, we have previously demonstrated th
Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication.: J Virol. 1995 Aug;69(8):4906-13. Unique Identifier : AIDSLINE MED/95333270; Harrich D; Mavankal G; Mette-Snider A; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235-8594, USA.; The TAR element is a viral regulatory element extending from +1 to +60 in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, which is critical for activation by the transactivator protein Tat. Jurkat cell lines chronically infected with viruses containing HIV-1 TAR element mutations are extremely de
Human herpesvirus 6A ts suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters.: J Virol. 1995 Aug;69(8):4933-40. Unique Identifier : AIDSLINE MED/95333273; Araujo JC; Doniger J; Kashanchi F; Hermonat PL; Thompson J; Rosenthal LJ; Department of Microbiology and Immunology, Georgetown University; Medical Center, Washington, D.C. 20007, USA.; Human herpesvirus 6 strain U1102 (HHV-6A) was shown to contain a 1,473-bp functional transformation suppressor gene (ts). ts exhibited 24% identity and 51% similarity to adeno-associated virus type 2 Rep68/78. Like adeno-associated virus type 2 Rep68/78, HHV-6A ts suppressed H-ras transformation of NIH 3T3 cells. Supp
Inhibition of RNA splicing at the Rous sarcoma virus src 3' splice site is mediated by an interaction between a negative cis element and a chicken embryo fibroblast nuclear factor.: J Virol. 1995 Aug;69(8):5068-76. Unique Identifier : AIDSLINE MED/95333289; Amendt BA; Simpson SB; Stoltzfus CM; Department of Microbiology, University of Iowa, Iowa City 52242,; USA.; In permissive Rous sarcoma virus-infected chicken embryo fibroblasts (CEF), approximately equimolar amounts of env and src mRNAs are present. In nonpermissive mammalian cells, the src mRNA level is elevated and env mRNA level is reduced. A cis element in the region between the env gene and the src 3 splice site, whic
Transactivation of the human T-cell lymphotropic virus type 1 Tax1-responsive 21-base-pair repeats requires Holo-TFIID and TFIIA.: J Virol. 1995 Aug;69(8):5077-86. Unique Identifier : AIDSLINE MED/95333290; Duvall JF; Kashanchi F; Cvekl A; Radonovich MF; Piras G; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892, USA.; The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia and tropical spastic paraparesis/HTLV-1-associated myelopathy. The HTLV-1 Tax1 gene product has been shown to transactivate transcription of viral and cellular promoters. To examine the biochemical mechanism of Tax1
Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.: J Virol. 1995 Aug;69(8):5103-12. Unique Identifier : AIDSLINE MED/95333293; Desai-Yajnik V; Hadzic E; Modlinger P; Malhotra S; Gechlik G; Samuels HH; Department of Medicine, New York University Medical Center, New; York 10016, USA.; Thyroid hormone (T3) receptor (T3R) regulates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) by binding to and activating thyroid hormone response elements (TREs) embedded within the viral NF-kappa B and Sp1 motifs. The TREs within the NF-kappa B sites are necessary for activation by T3 in
Repair and evolution of nef in vivo modulates simian immunodeficiency virus virulence.: J Virol. 1995 Aug;69(8):5117-23. Unique Identifier : AIDSLINE GENBANK/X86732; Whatmore AM; Cook N; Hall GA; Sharpe S; Rud EW; Cranage MP; Centre for Applied Microbiology and Research, Wiltshire, United; Kingdom.; Experimental evidence from the simian immunodeficiency virus (SIV) model of AIDS has shown that the nef gene is critical in the pathogenesis of AIDS. Consequently, nef is of considerable interest in both antiviral drug and vaccine development. Preliminary findings in two rhesus macaques indicated that a deletion of on
Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.: J Virol. 1995 Aug;69(8):5124-7. Unique Identifier : AIDSLINE MED/95333296; Siebelink KH; Huisman W; Karlas JA; Rimmelzwaan GF; Bosch ML; Osterhaus AD; Institute of Virology, Erasmus University Rotterdam, The; Netherlands.; Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations wi
Interaction of nuclear protein p140 with human immunodeficiency virus type 1 TAR RNA in mitogen-activated primary human T lymphocytes.: J Virol. 1995 Aug;69(8):5156-63. Unique Identifier : AIDSLINE MED/95333303; Rothblum CJ; Jackman J; Mikovits J; Shukla RR; Kumar A; Department of Biochemistry and Molecular Biology, George; Washington University Medical Center, Washington, D.C. 20037,; USA.; Several lines of evidence suggest that cellular proteins play a role during human immunodeficiency virus type 1 (HIV-1) Tat-mediated trans activation. A recent report from this laboratory has shown that a 140-kDa HeLa nuclear protein (p140) binds specifically to the lower stem region of the Tat response element, TAR R
Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.: J Virol. 1995 Aug;69(8):5164-6. Unique Identifier : AIDSLINE MED/95333304; Endres CL; Bergquam EP; Axthelm MK; Wong SW; Division of Pathobiology and Immunology, Oregon Regional Primate; Research Center, Beaverton 97006, USA.; We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated
Identification and mapping of inhibitory sequences in the human immunodeficiency virus type 2 vif gene.: J Virol. 1995 Aug;69(8):5167-70. Unique Identifier : AIDSLINE MED/95333305; Reddy TR; Kraus G; Suhasini M; Leavitt MC; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665, USA.; Human immunodeficiency virus (HIV) regulates the expression of its genes temporally at the mRNA processing step. A subset of the mRNA species which encode the structural and some accessory genes contains inhibitory sequences (INS or CRS elements) which prevent nuclear export of the RNA or its utilization in the cytopl
Effect of amino acid substitutions on calmodulin binding and cytolytic properties of the LLP-1 peptide segment of human immunodeficiency virus type 1 transmembrane protein.: J Virol. 1995 Aug;69(8):5199-202. Unique Identifier : AIDSLINE MED/95333311; Tencza SB; Miller MA; Islam K; Mietzner TA; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.; Previous studies have identified two highly basic amphipathic helical regions in the human immunodeficiency virus type 1 transmembrane protein that, in vitro, display both cytolytic and calmodulin-binding and -inhibitory properties that could contribute to cellular dysfunctions and cytopathogenesis during a persistent
Xenotransplantation workshop ponders science, safety of animal tissue grafts [news]: JAMA. 1995 Jul 26;274(4):285, 287-8. Unique Identifier : AIDSLINE MED/95333482; Stephenson J
Reducing the impact of opportunistic infections in patients with HIV infection. New guidelines [editorial]: JAMA. 1995 Jul 26;274(4):347-8. Unique Identifier : AIDSLINE MED/95333506; Kaplan JE; Masur H; Jaffe HW; Holmes KK
[A hemodialysis patient with HTLV-1-associated myelopathy (HAM)]: Nippon Jinzo Gakkai Shi. 1995 May;37(5):307-10. Unique Identifier : AIDSLINE MED/95333572; Takeda F; Inumaru T; Arai T; Momose T; Morio K; Matsuzaki K; Sano M; Koide K; Ono S; Shimizu N; Third Department of Internal Medicine, Teikyo University School; of Medicine, Japan.; We report here a case of maintenance hemodialysis with HTLV-1 associated myelopathy (HAM). A 53-year-old female hemodialysis patient was admitted to Teikyo University Ichihara hospital because of paralytic ileus. She had a history of blood transfusion and had been under dialysis treatment for 8 years. She had experien
[Uveitis associated with rifabutin treatment. Apropos of 3 patients]: Klin Monatsbl Augenheilkd. 1995 May;206(5):388-90. Unique Identifier : AIDSLINE MED/95333638; Chevalley GF; Kaiser L; Bouchenaki N; Baglivo E; Kress O; Clinique universitaire d'ophtalmologie de Geneve.; Disseminated Mycobacterium-avium complex (MAC) infection develops in most patients with AIDS. We report three cases of anterior uveitis with vitritis in AIDS patients treated by the combination of rifabutin, clarithromycin and ethambutol for MAC bacteremia. Uveitis secondary to the introduction of rifabutin treatment
Parents' attitudes and beliefs about HIV/AIDS prevention with condom availability in New York City public high schools.: J Sch Health. 1995 Mar;65(3):101-6. Unique Identifier : AIDSLINE MED/95333712; Guttmacher S; Lieberman L; Ward D; Radosh A; Rafferty Y; Freudenberg N; New York University, NY 10003, USA.; In 1991, the New York City Board of Education expanded HIV/AIDS education to include condom availability in every public high school. The evaluation was designed to examine the impact of the program on students and monitor changes in parent s knowledge, attitudes, and beliefs. Findings are reported from the first wave
The possible roles of sperm and sperm antibodies in the pathogenesis and treatment of AIDS.: Med Hypotheses. 1995 Mar;44(3):155-8. Unique Identifier : AIDSLINE MED/95333952; Eldor J; Theoretical Medicine Institute, Jerusalem, Israel.; Intravenous injections of donor sperm may possibly be of value to AIDS patients. The immunological basis for this proposal is reviewed in detail. Donor sperm introduced into the blood of a healthy patient produces anti-sperm antibodies which may become attached to the T-cells and cause their depletion. Reintroduction
Sudden infant death syndrome (SIDS): immunoglobulins and hypoxia.: Med Hypotheses. 1995 Mar;44(3):202-6. Unique Identifier : AIDSLINE MED/95333961; Reid GM; Tervit H; A body of opinion suggests that immunological overstimulation of the gastrointestinal and respiratory mucosa is involved in SIDS. The local stimulation of immunoglobulin concentration in the respiratory mucosa is said to be the consequence of an accentuated reaction to a trivial infection (1-4). One hypothesis is that
Polio vaccines and the origin of AIDS: clarification [letter; comment]: Med Hypotheses. 1995 Mar;44(3):226. Unique Identifier : AIDSLINE MED/95333965; Elswood B; Stricker RB
Isolation of HIV-1 from experimentally contaminated multidose local anaesthetic vials [letter; comment] [see comments]: Med J Aust. 1995 Jul 3;163(1):53, 56. Unique Identifier : AIDSLINE MED/95333987; Byrne JJ
Isolation of HIV-1 from experimentally contaminated multidose local anaesthetic vials [letter; comment]: Med J Aust. 1995 Jul 3;163(1):56. Unique Identifier : AIDSLINE MED/95333989; Davis AR
[Epidemiology of deep-seated, domestic mycoses]: Mycoses. 1994;37 Suppl 2:1-7. Unique Identifier : AIDSLINE MED/95334028; Muller J; Sektion Mykologie, Albert-Ludwigs-Universitat Freiburg i. Br.,; BR Deutschland.; The opportunistic character of deep-seated mycoses depends on granulocyte-based defense in candidosis and aspergillosis. Therefore, haematological, patients represent the group of highest risk. Mucocutaneous candidosis is controlled by macrophages. Cryptococcus neoformans forces its way into the human host via causing
[Treatment of invasive aspergillosis]: Mycoses. 1994;37 Suppl 2:20-6. Unique Identifier : AIDSLINE MED/95334030; Martino P; Cattedra di Ematologia, Universita degli Studi di Roma La; Sapienza, Italien.; With the increasing use of aggressive chemotherapy in patients with malignancies causing prolonged periods of granulocytopenia and severe mucosal damage and the progresses made in the prophylaxis and treatment of bacterial infections, the risk of invasive mycosis has increased particularly in patients with haematologi
[Pharmacokinetics of itraconazole]: Mycoses. 1994;37 Suppl 2:27-33. Unique Identifier : AIDSLINE MED/95334031; Cauwenbergh G; Janssen Pharmaceutica, Beerse, Belgien.; Itraconazole is a lipophilic triazole antifungal with a broad spectrum of activity. Most of the important fungal pathogens respond to itraconazole concentrations of 100 ng/ml. Therefore, itraconazole is suitable for treatment of a variety of systemic mycoses, as aspergillosis, cryptococcosis, candidosis as well as non
[Therapy of invasive aspergillosis with itraconazole: our own experiences and review of the literature]: Mycoses. 1994;37 Suppl 2:42-51. Unique Identifier : AIDSLINE MED/95334034; Kreisel W; Abteilung Gastroenterologie und Hepatologie, Medizinische; Universitatsklinik, Freiburg, Deutschland.; Invasive aspergillosis is one of the most threatening infections in immunocompromised patients of risk. The classical standard therapy of deep-seated mycoses--amphotericin B as monotherapy or in combination with 5-fluorocytosine--shows a response rate in aspergillosis of 55-60%. The new triazole compound itraconazole
[Therapy of systemic candidiasis]: Mycoses. 1994;37 Suppl 2:52-5. Unique Identifier : AIDSLINE MED/95334035; Meunier F; European Organization for Research and Treatment of Cancer EORTC,; Central Office, Brussel, Belgien.; Deep seated candidosis are the most common invasive fungal infections occurring in various categories of patients including those with cancer, burns as well as patients with AIDS or undergoing organ transplantation. Various clinical entities have to be distinguished with implications for diagnostic procedures as well
[Therapy of candidiasis and cryptococcosis in AIDS]: Mycoses. 1994;37 Suppl 2:56-63. Unique Identifier : AIDSLINE MED/95334036; Just-Nubling G; Klinikum, J.W. Goethe-Universitat Frankfurt am Main, BR; Deutschland.; Fungal infections figures large in HIV-infected patients. Candida infections of the mucous membranes belong to the main manifestations of immunodeficiency in HIV infection. For therapy and prophylaxis of oropharyngeal candidosis mainly systemically acting azoles as ketoconazole, fluconazole and itraconazole are applie
[Aspects in the diagnosis of deep-seated opportunistic mycoses]: Mycoses. 1994;37 Suppl 2:8-19. Unique Identifier : AIDSLINE MED/95334040; Fegeler W; Institut fur Medizinische Mikrobiologie, Westfalischen; Wilhelms-Universitat Munster, BR Deutschland.; Possibilities for the mycological, mycoserological and clinical diagnostics of deep-seated opportunistic mycoses--cryptococcosis, aspergillosis and candidosis--are shown. Improvements of the diagnostics and interpretation by consideration of pathogenesis and clinical situation are discussed.
[Coping with HIV infection and motivation for therapy in multi-drug dependent patients]: Nervenarzt. 1995 May;66(5):361-6. Unique Identifier : AIDSLINE MED/95334127; Grube M; Psychiatrische Klinik, Frankfurt/M.; The intrapsychological process of working through the five stages of death in terminally ill patients (according to Kubler-Ross) was documented by videotaping semistructured interviews. There were 67 i.v. drug-dependent polytoxic HIV-positive inpatients. An inquiry was also made into their social niveau, the course of
[Incidence and etiology of psychotic disorders in HIV infected patients]: Nervenarzt. 1995 May;66(5):367-71. Unique Identifier : AIDSLINE MED/95334128; Niederecker M; Naber D; Riedel R; Perro C; Goebel FD; Psychiatrische Klinik, Universitat Munchen.; There are numerous case reports on psychoses in AIDS patients and, although more seldom, also in HIV-positive patients in early stages of infection; however, systematic investigations on the frequency, e.g., relevant for the indication of an HIV test in psychiatric patients, are missing. For this study, 1046 HIV-posit
Symptomatic arachnoiditis ossificans of the thoracic spine. Case report.: Paraplegia. 1995 Apr;33(4):224-7. Unique Identifier : AIDSLINE MED/95334302; Toribatake Y; Baba H; Maezawa Y; Umeda S; Tomita K; Department of Orthopaedic Surgery, School of Medicine, Kanazawa; University, Ishikawa, Japan.; This report describes a man aged 65 years who developed spastic paraparesis secondary to arachnoiditis ossificans in the thoracic spine. Over 35 years previously, in Southeast Asia, the patient had received repeated lumbar punctures in the treatment of meningitis possibly associated with malarial fever. He had multipl
Cytokine and immunoglobulin subclass responses of rats to infection with Eimeria nieschulzi.: Parasitology. 1995 Jul;111 ( Pt 1):51-7. Unique Identifier : AIDSLINE MED/95334311; Smith NC; Ovington KS; Deplazes P; Eckert J; Institute of Parasitology, University of Zurich, Switzerland.; SIV rats infected with a high dose (50,000 oocysts) of Eimeria nieschulzi displayed clinical symptoms of coccidiosis such as diarrhoea (days 6 and 7 post-primary infection) and weight loss (days 6-8 post-primary infection) and were completely immune to challenge with a similar dose. The ability of rats to produce tumo
Pediatric AIDS.: Pediatr Clin North Am. 1995 Aug;42(4):969-92. Unique Identifier : AIDSLINE MED/95334345; Chadwick EG; Yogev R; Department of Pediatrics, Northwestern University Medical School,; Chicago, Illinois, USA.; An estimated 1 million children worldwide have AIDS. Pediatricians should be aware of this disease and its many facets. This article provides information on the etiology and pathogenesis of AIDS in children, as well as its manifestations on the body. Prevention and clinical management are also reviewed.
Ribozyme-mediated RNA degradation in nuclei suspension.: Nucleic Acids Res. 1995 Jun 25;23(12):2223-8. Unique Identifier : AIDSLINE MED/95334376; Heidenreich O; Kang SH; Brown DA; Xu X; Swiderski P; Rossi JJ; Eckstein F; Nerenberg M; Scripps Research Institute, Department of Neuropharmacology, La; Jolla, CA 92037, USA.; Ribozymes containing 2 -fluoro- and 2 -amino-modified pyrimidine nucleosides in combination with terminal phosphorothioate linkages were targeted against HTLV-I tax RNA. In order to examine the activity of such chemically modified ribozymes in the nuclear environment, they were incubated with nuclei of a Tax-transform
Improved accumulation and activity of ribozymes expressed from a tRNA-based RNA polymerase III promoter.: Nucleic Acids Res. 1995 Jun 25;23(12):2259-68. Unique Identifier : AIDSLINE MED/95334381; Thompson JD; Ayers DF; Malmstrom TA; McKenzie TL; Ganousis L; Chowrira BM; Couture L; Stinchcomb DT; Ribozyme Pharmaceuticals Inc., Boulder, CO 80301, USA.; RNA polymerase III (pol III) transcripts are abundant in all cells. Therefore, pol III promoters may be ideal for expressing high levels of exogenous RNAs, such as antisense RNAs, decoy RNAs and ribozymes, in many different cell types. We have improved accumulation of recombinant RNAs expressed from a human meti tRNA-
Case management of HIV-infected children in Missouri.: Public Health Rep. 1995 May-Jun;110(3):355-6. Unique Identifier : AIDSLINE MED/95334559; Scott DE; Hu DJ; Hanson IC; Fleming PL; Northup T; Bureau of STD/HIV Prevention, Missouri Department of Health,; Jefferson City, 65102-0570, USA.; The early referral of HIV-exposed children and their mothers to coordinated medical and social services has become increasingly important. In July 1989, the Missouri Department of Health initiated the Service Coordination Program to provide individualized referral (case management) for Missouri residents who were repo
Tuberculosis. Captain of all these men of death.: Radiol Clin North Am. 1995 Jul;33(4):619-39. Unique Identifier : AIDSLINE MED/95334564; Rubin SA; Department of Radiology, University of Texas Medical Branch,; Galveston, Texas, USA.; The intent of this review was to familiarize the reader with the fascinating history of TB. I quote from Robert Louis Stevenson: It is not a hard thing to know what to write; the hard thing is to know what to leave out. Also, this review by its very nature must be incomplete. It is certain that TB was present before t
A clinical view of tuberculosis.: Radiol Clin North Am. 1995 Jul;33(4):641-53. Unique Identifier : AIDSLINE MED/95334565; Hopewell PC; University of California, San Francisco, USA.; Although tuberculosis (TB) involves the lungs most commonly, nonpulmonary sites of disease are increasingly common. The modes of presentation of TB and the approach to diagnosis depend on the extent of the disease and the organs that are affected. In addition, TB involving any site commonly causes systemic symptoms su
Tuberculosis and AIDS.: Radiol Clin North Am. 1995 Jul;33(4):707-17. Unique Identifier : AIDSLINE MED/95334569; Goodman PC; Department of Radiology, Duke University Medical Center, Durham,; North Carolina, USA.; In the mid-1980s, the incidence of tuberculosis (TB) in the United States increased. Recently, TB became an index diagnosis for AIDS. Chest radiographs in patients with AIDS and TB may be atypical; various features are addressed in this article. Radiologists should be aware of the poss
Role of CT and MR imaging in the management of tuberculous spondylitis.: Radiol Clin North Am. 1995 Jul;33(4):787-804. Unique Identifier : AIDSLINE MED/95334574; Sharif HS; Morgan JL; al Shahed MS; al Thagafi MY; Department of Radiology and Imaging, Armed Forces Hospital,; Riyadh, Kingdom of Saudi Arabia.; Tuberculous spondylitis is an infection involving one or more of the components of the spine, namely the vertebral body, intervertebral disc and ligaments, paravertebral soft tissues, and the epidural space. The causative organism belongs to one of the different strains of Mycobacterium tuberculosis. The role of CT an
MR imaging and CT of central nervous system tuberculosis in the patient with AIDS.: Radiol Clin North Am. 1995 Jul;33(4):805-20. Unique Identifier : AIDSLINE MED/95334575; Villoria MF; Fortea F; Moreno S; Munoz L; Manero M; Benito C; Department of Radiology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.; CNS TB represents a disease that complicates AIDS with an increasing incidence in endemic areas as well as in developed countries in those patients who have some risk factors such as intravenous drug abuse. Although TB infection of the CNS in AIDS patients may follow a rapidly progressive course, the imaging findings
An economic evaluation of alternative programme designs for tuberculosis control in rural Uganda.: Soc Sci Med. 1995 May;40(9):1203-12. Unique Identifier : AIDSLINE MED/95334764; Saunderson PR; Leprosy/TB Control Division, ALERT, Addis Ababa, Ethiopia.; Tuberculosis (TB) and AIDS are infections that are among the most feared of all diseases. Both have been widely discussed by the western media in recent months, for a variety of reasons, but it is the combination of the two diseases in an ever increasing number of patients that is causing concern to health planners an
gp120 and neurotoxicity in vivo [letter]: Trends Pharmacol Sci. 1995 Apr;16(4):122. Unique Identifier : AIDSLINE MED/95334854; Lipton SA; Brenneman DE; Silverstein FS; Masliah E; Mucke L
[Tumor vaccination in renal cell carcinoma with and without interleukin-2 (IL-2) as adjuvant. A clinical contribution to the development of effective active specific immunization]: Urologe A. 1995 May;34(3):215-20. Unique Identifier : AIDSLINE MED/95334878; Pomer S; Thiele R; Staehler G; Drehmer I; Lohrke H; Schirrmacher V; Abteilung Urologie, Universitat Heidelberg.; Interleukin 2 (IL2) production is known to bypass T-helper-cell function in the generation of an antitumour response. The present analysis was designed to assess the effects of application of renal cancer vaccine with and without IL2 on delayed-type hypersensitivity (DTH) skin responses to the vaccine itself and tumou
[Herpes simplex virus type II infection as an exophytic endobronchial tumor]: Wien Klin Wochenschr. 1995;107(11):344-6. Unique Identifier : AIDSLINE MED/95335033; Armbruster C; Drlicek M; II. Interne Abteilung des Pulmologischen Zentrums der Stadt Wien.; We report the case of a 52 year-old homosexual AIDS patients suffering from Herpes simplex virus type II infection of the esophagus and the bronchial system. The chest radiograph revealed a homogeneous, well-defined consolidation of the right upper lobe. Gastroscopy showed an ulcer of the esophagus and gastritis of th
[Cellular immunodeficiency (including AIDS): incidence and length of stay of hospitalized cases in Austria in 1990]: Soz Praventivmed. 1995;40(3):157-60. Unique Identifier : AIDSLINE MED/95335087; Haidinger G; Kunze M; Vutuc C; Abteilung fur Epidemiologie, Universitat Wien.; The incidence of cellular immunodeficiency (including AIDS), treated at hospitals in Austria in the year 1990, was 3.8 per 100,000 (n = 294, males 6.3 per 100,000, females 1.5 per 100,000). On the average every patient with this diagnosis was admitted to the hospital 3.6 times per
Methadone treatment and risk of HIV infection in drug users without legal access to clean injection equipment.: Soz Praventivmed. 1995;40(3):183-90. Unique Identifier : AIDSLINE MED/95335090; Wietlisbach V; Meystre-Agustoni G; Martin J; Institute of Social and Preventive Medicine, University of; Lausanne.; The particular situation of the Swiss canton of Vaud (population 550,000) provides favourable observational conditions to assess the efficacy of a methadone treatment scheme in reducing the risk of human immunodeficiency virus (HIV) infection among drug users. On the one hand, the canton has a long tradition of methad
Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings.: AJNR Am J Neuroradiol. 1995 Apr;16(4):703-11. Unique Identifier : AIDSLINE MED/95335406; Brightbill TC; Ihmeidan IH; Post MJ; Berger JR; Katz DA; Department of Radiology, University of Miami (Fla) School of; Medicine/Jackson Memorial Center, USA.; PURPOSE: To evaluate and describe the neuroimaging findings of patients with neurosyphilis. METHODS: The neuroimaging studies of 35 patients with documented neurosyphilis were reviewed. Diagnosis was established in 34 patients with cerebrospinal fluid for a Venereal Disease Research Laboratory test, complemented by au
Use of the polymerase chain reaction technique on induced-sputum samples for the diagnosis of Pneumocystis carinii pneumonia in HIV-infected patients. A clinical and cost-analysis study.: Am J Clin Pathol. 1995 Jul;104(1):72-5. Unique Identifier : AIDSLINE MED/95335568; Chouaid C; Roux P; Lavard I; Poirot JL; Housset B; Services de Pneumologie, Hopital Saint Antoine, Paris, France.; The purpose of this study was to assess the sensitivity and specificity of the polymerase chain reaction (PCR) on induced sputum (IS) for the diagnosis of Pneumocystis carinii pneumonia (PCP) in HIV-infected patients, as well as its diagnostic value and cost as a routine clinical tool. Forty-nine patients with suspect
Pyrimethamine analysis by enzyme inhibition and HPLC assays.: Am J Clin Pathol. 1995 Jul;104(1):82-8. Unique Identifier : AIDSLINE MED/95335570; Roberts WL; Reynolds KM; Heimer R; Jatlow PI; Rainey PM; Department of Laboratory Medicine, Yale University School of; Medicine, New Haven, Connecticut, USA.; Pyrimethamine is an antiparasitic agent currently used for therapy of central nervous system toxoplasmosis, a disease seen with increasing frequency in association with the AIDS epidemic. Monitoring of pyrimethamine levels may be particularly important because patients may be treated with high doses of the drug for ex
Megace for AIDS cachexia: food for thought.: Am J Gastroenterol. 1995 Jul;90(7):1180-1. Unique Identifier : AIDSLINE MED/95335611; Novak J; Barkin JS; Division of Gastroenterology, University of Miami School of; Medicine, FL, USA.
Increasing resistance of Candida albicans to fluconazole.: Am J Gastroenterol. 1995 Jul;90(7):1182. Unique Identifier : AIDSLINE MED/95335612; Oldfield EC 3rd; Department of Medicine (Infectious Diseases), Eastern VA School; of Medicine, Norfolk, VA, USA.
Prevalence of intestinal microsporidiosis in HIV-infected individuals [letter; comment]: Am J Gastroenterol. 1995 Jul;90(7):1184-5. Unique Identifier : AIDSLINE MED/95335614; Carlson SJ; Craig RM
Kawasaki's syndrome in a man with the human immunodeficiency virus.: Am J Ophthalmol. 1995 Jul;120(1):117-8. Unique Identifier : AIDSLINE MED/95335706; Wolf CV 2nd; Wolf JR; Parker JS; Department of Ophthalmology, University of Alabama at Birmingham,; USA.; PURPOSE/METHODS: We examined a 25-year-old man who was positive for the human immunodeficiency virus (HIV) with Kawasaki s syndrome. He responded dramatically to intravenous immunoglobulin. RESULTS/CONCLUSIONS: Although Kawasaki s syndrome is exceedingly rare in adults, it should be considered in any patient with feve
HIV-gp120 activates large-conductance apamin-sensitive potassium channels in rat astrocytes.: Am J Physiol. 1995 Jun;268(6 Pt 1):C1440-9. Unique Identifier : AIDSLINE MED/95335753; Bubien JK; Benveniste EN; Benos DJ; Department of Medicine, University of Alabama at Birmingham; 35294, USA.; Central nervous system (CNS) involvement usually occurs in individuals infected with human immunodeficiency virus type 1 (HIV-1). Evidence is now accumulating that neurons and astrocytes may be functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages and/or
Toxoplasma gondii antibodies in pregnant women and their newborns in Dar es Salaam, Tanzania.: Am J Trop Med Hyg. 1995 Jun;52(6):546-8. Unique Identifier : AIDSLINE MED/95335980; Doehring E; Reiter-Owona I; Bauer O; Kaisi M; Hlobil H; Quade G; Hamudu NA; Seitz HM; Institute of Medical Parasitology, University of Bonn, Germany.; The sera of 849 Tanzanian pregnant women were tested at delivery for Toxoplasma gondii antibodies with the Sabin-Feldman dye test (DT) and an immunosorbent agglutination assay. A total of 296 (35%) of these women had DT titers greater than 1:4. The percentage of women with dye test titers greater than 1:4 was 34-37% r
[Inhibitory effects of menogaril to the proliferation of HTLV-I infected T-cell lines and fresh tumor cells from adult T-cell leukemia patients]: Gan To Kagaku Ryoho. 1995 Jul;22(8):1057-61. Unique Identifier : AIDSLINE MED/95336185; Hata H; Matsuzaki H; Kuribayashi N; Takemoto S; Matsuoka M; Takatsuki K; Second Dept. of Internal Medicine, Kumamoto University School of; Medicine.; Anti-cancer effect of anthracyclines are well established. In vitro inhibitory effects of a new anthracyclin-derivative drug, menogaril (TUT-7) which is developed for oral administration, on three human T-cell leukemia virus type-I (HTLV-I) infected T-cell lines, a HTLV-I non-infected T cell line, and fresh tumor cell
Porphyria cutanea tarda and hepatitis C viral infection. A clinical and virologic study.: Arch Dermatol. 1995 Jul;131(7):801-4. Unique Identifier : AIDSLINE MED/95336225; Cribier B; Petiau P; Keller F; Schmitt C; Vetter D; Heid E; Grosshans E; Dermatology Clinic, University Hospital, Strasbourg, France.; BACKGROUND AND DESIGN: The role of hepatitis C virus (HCV) infection in porphyria cutanea tarda (PCT) is probable since the global HCV antibody prevalence among patients with PCT is about 70%. The purpose of this study was to evaluate the virologic characteristics in 12 patients with sporadic PCT and in one patient wi
Synthesis and biological investigations of some new thiazolylbenzimidazoles and benzimidazolylthiazolo[3,2-a]pyridines.: Arch Pharm (Weinheim). 1995 Apr;328(4):325-8. Unique Identifier : AIDSLINE MED/95336260; Rida SM; Habib NS; Badawey EA; Fahmy HT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy,; University of Alexandria, Egypt.; 2-[(4-Oxo-4,5-dihydrothiazol-2-yl)methyl]-1H-benzimidazole (2) was prepared through the reaction of 2-cyanomethyl-1H-benzimidazole (1) with thioglycolic acid. The syntheses of its arylidene 3 and diazo-coupled compounds 5 and the cyclization of the aforementioned thiazolylbenzimidazole to benzimidazolylthiazolo[3,2-a]
Crack, crack house sex, and HIV risk.: Arch Sex Behav. 1995 Jun;24(3):249-69. Unique Identifier : AIDSLINE MED/95336278; Inciardi JA; Center for Drug and Alcohol Studies, University of Delaware,; Newark 19716, USA.; Limited attention has been focused on HIV risk behaviors of crack smokers and their sex partners, yet there is evidence that the crack house and the crack-using life-style may be playing significant roles in the transmission of HIV and other sexually transmitted diseases. The purposes of this research were to study th
LTR-directed homologous recombination of full-length HIV-1 provirus clone in recA(-) bacteria.: Arch Virol. 1995;140(6):1007-14. Unique Identifier : AIDSLINE MED/95336307; Yamada K; Morozumi H; Okamoto T; Department of Molecular Genetics, Nagoya City University Medical; School, Aichi, Japan.; During molecular cloning of full-length retroviral plasmid clones occurrence of homologous recombination (HR) between LTR regions is frequently observed. In order to evaluate appropriate host bacterial strains for cloning such HR-prone plasmids, we utilized a linearized template plasmid containing a full-length HIV-1
[Morphologic characteristics of digestive tract mucosa in virus infections]: Arkh Patol. 1995 Mar-Apr;57(2):21-5. Unique Identifier : AIDSLINE MED/95336326; Parkhmenko IuG; Barkhina TG; Biopsies of mucous membranes of the alimentary canal in widespread viral infections (measles, chicken pox, HIV infection) in 17 to 40-year-old patients of both sexes were examined. Intracellular oedema and viral particles are found in the epithelial cells. The presence of membrane-granular structures in HIV-infection
Brazilian studies on tropical spastic paraparesis. A meta-analysis.: Arq Neuropsiquiatr. 1994 Dec;52(4):585-91. Unique Identifier : AIDSLINE MED/95336393; De Castro Costa CM; Carton H; Goubau P; D'Almeida JA; Hospital das Clinicas, Servico de Neurologia, Universidade; Federal do Ceara (UFCE), Brasil.; Tropical spastic paraparesis (TSP) is a chronic progressive myelopathy and in most of the cases has a retroviral (HTLV-1) etiology, when it is denominated HTLV-1 associated-mielopathy (HAM/TSP). Around 433 cases of TSP have been described in Northeast and Southeast Brazil . Among th
Analysis of leucocytes and lymphocyte subsets in cats with naturally-occurring cryptococcosis but differing feline immunodeficiency virus status.: Aust Vet J. 1995 Mar;72(3):93-7. Unique Identifier : AIDSLINE MED/95336424; Walker C; Malik R; Canfield PJ; Department of Veterinary Pathology, Unviersity of Sydney, New; South Wales.; Although cryptococcosis is a well-characterised disease of cats, the factors predisposing individuals to infection are unknown. As an indication of the immune status of an individual, lymphocyte subsets can be analysed. Reference ranges for feline lymphocyte subsets (Pan T+, CD4+, CD8+ and B cells) were established us
HIV infection decreases intracellular nicotinamide adenine dinucleotide [NAD]: Biochem Biophys Res Commun. 1995 Jul 6;212(1):126-31. Unique Identifier : AIDSLINE MED/95336430; Murray MF; Nghiem M; Srinivasan A; Department of Medicine, Univ. of PA School of Medicine,; Philadelphia, USA.; We report that HIV-1 infection of human cells in vitro leads to significant decreases in the intracellular concentration of NAD. This decrease varies with viral load and HIV strain. In tissue culture, cells lacking CD4 receptors or cells incubated with heat inactivated virus do not demonstrate this decrease in NAD. Ni
High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane.: Arthritis Rheum. 1995 Jul;38(7):946-52. Unique Identifier : AIDSLINE MED/95336488; Cohen SB; Katsikis PD; Chu CQ; Thomssen H; Webb LM; Maini RN; Londei M; Feldmann M; Kennedy Institute of Rheumatology, Sunley Division, London, UK.; OBJECTIVE. To characterize the cytokine profile of the activated T cell population derived from the synovial membrane of rheumatoid arthritis (RA) patients. METHODS. Interleukin-2 ( IL-2 ) was used to select for in vivo-activated T cells from the synovial membrane of 2 p
Flow cytometric three-color determination of CD4 T-lymphocytes on blood specimens from AIDS patients who have a large number of contaminating non-lymphocytes.: Asian Pac J Allergy Immunol. 1994 Dec;12(2):105-9. Unique Identifier : AIDSLINE MED/95336545; Pattanapanyasat K; Pengruangrojanachai V; Thepthai C; Suwanagool S; Wasi C; Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol; University, Bangkok, Thailand.; A three-color flow cytometric determination of CD4 T-lymphocytes on whole blood specimens from AIDS patients which contain a high proportion of non-lymphocyte elements is described. Peripheral blood cells were stained by a three-color method using monoclonal antibodies conjugated respectively with fluorescein isothioc
Peripheral blood lymphocyte subsets after allogeneic bone marrow transplantation: reconstitution and correlation with the occurrence of acute graft-versus-host disease.: Asian Pac J Allergy Immunol. 1994 Dec;12(2):117-23. Unique Identifier : AIDSLINE MED/95336547; Chan EY; Chiu EK; So MK; Lie AK; Chan TK; Department of Pathology, University of Hong Kong, Queen Mary; Hospital.; Peripheral blood lymphocyte subsets were enumerated at regular intervals during the first year after allogeneic bone marrow transplantation (BMT) in 21 Chinese patients. Eight of these patients had acute graft-versus-host disease (GVHD) while they were assessed at the time of engraftment. Our results show in patients
The interleukin network in the immunopathogenesis of oral diseases [see comments]: Asian Pac J Allergy Immunol. 1994 Dec;12(2):161-8. Unique Identifier : AIDSLINE MED/95336554; Sosroseno W; Herminajeng E; Goeno S; Department of Dental Public Health, Faculty of Dentistry, Gadjah; Mada University, Yogyakarta, Indonesia.; Interleukins produced by both lymphoid and non-lymphoid cells play a crucial role in the immune response. This paper discusses the possible interleukin network in the immunopathogenesis of some oral diseases. In chronic inflammatory periodontal diseases and periapical inflammation, interleukins such as IL-1 and IL-6 m
Histopathologic spectrum of AIDS-associated lesions in Maharaj Nakorn Chiang Mai Hospital.: Asian Pac J Allergy Immunol. 1994 Dec;12(2):95-104. Unique Identifier : AIDSLINE MED/95336558; Bhoopat L; Thamprasert K; Chaiwun B; Attasiri C; Vithayasai P; Chaimongkol B; Limpichankit T; Sirisanthana V; Department of Pathology, Faculty of Medicine, Chiang Mai; University, Thailand.; The histopathological alterations in various organs and the presence of AIDS-associated lesions were studied in 86 biopsy and 29 necropsy specimens of AIDS patients. The most common cancer seen in this study were malignant lymphomas (4% of cases) with development of extensive extranodal lymphomatous involvement from t
Autoimmunity following neonatal tolerance to alloantigens: role of donor I-A and I-E molecules.: J Autoimmun. 1995 Apr;8(2):177-92. Unique Identifier : AIDSLINE MED/95336594; Kramar G; Schurmans S; Berney M; Izui S; del Giudice G; Lambert PH; World Health Organization-Immunology Research and Training; Center, Department of Pathology, CMU, Geneva, Switzerland.; The injection of semi-allogeneic F1 spleen cells into newborn mice of a parental strain induces a state of immune tolerance characterized by anti-donor CTL unresponsiveness and the appearance of a transient SLE-like autoimmune syndrome associating autoantibody production, hypergammaglobulinemia, splenomegaly and glome
The time course and characterization of mercuric chloride-induced immunopathology in the brown Norway rat.: J Autoimmun. 1995 Apr;8(2):193-208. Unique Identifier : AIDSLINE MED/95336595; Qasim FJ; Thiru S; Mathieson PW; Oliveira DB; Department of Medicine, Cambridge University School of Clinical; Medicine, Addenbrooke's Hospital, UK.; Mercuric chloride (HgCl2) induces an autoimmune syndrome in the Brown Norway (BN) rat which includes widespread tissue injury. There is necrotizing leucocytoclastic vasculitis in the gut with maximal injury occurring 2 weeks after the start of HgCl2 injections. There is evidence th
Insulin-secretory-granule specific T cell clones in human IDDM.: J Autoimmun. 1995 Apr;8(2):221-34. Unique Identifier : AIDSLINE MED/95336597; Chang JC; Linarelli LG; Laxer JA; Froning KJ; Caralli LL; Brostoff SW; Carlo DJ; Immune Response Corporation, Carlsbad, CA 92008, USA.; T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu
Diseases involving the T-cell receptor/CD3 complex.: Crit Rev Oncol Hematol. 1995 Jun;19(2):131-47. Unique Identifier : AIDSLINE MED/95336630; Arnaiz-Villena A; Rodriguez-Gallego C; Timon M; Corell A; Pacheco A; Alvarez-Zapata D; Madrono A; Iglesias P; Regueiro JR; Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain.
The regulation of immunity to Leishmania major.: Annu Rev Immunol. 1995;13:151-77. Unique Identifier : AIDSLINE MED/95336674; Reiner SL; Locksley RM; Department of Medicine, University of California, San Francisco; 94143, USA.; Experimental infection with the intracellular protozoan Leishmania major constitutes a particularly versatile model for assessing the role of CD4+ subset development in the host response to infectious disease. The association of Th1 development with control of infection, and of Th2 cell development with progressive di
Prevention of AIDS transmission through screening of the blood supply.: Annu Rev Immunol. 1995;13:201-27. Unique Identifier : AIDSLINE MED/95336676; Galel SA; Lifson JD; Engleman EG; Stanford Medical School Blood Center, Stanford University School; of Medicine, California 94305, USA.; Shortly after the first cases of AIDS were reported in 1981, it became apparent that this disease was caused by a blood-borne infectious agent that could be transmitted by blood transfusion. Early reports documented a reduced ratio of CD4+ to CD8+ T cells not only in AIDS patients but also in likely carriers of the AI
New concepts in the immunopathogenesis of HIV infection.: Annu Rev Immunol. 1995;13:487-512. Unique Identifier : AIDSLINE MED/95336688; Pantaleo G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892-1876, USA.; The typical course of HIV infection is characterized by multiple phases that occur over a period of eight to ten years. A critical event in the initial establishment of HIV infection is the localization of HIV in lymphoid organs that serve as major reservoirs for HIV and as primary sites for virus replication. Despite
Principles for adoptive T cell therapy of human viral diseases.: Annu Rev Immunol. 1995;13:545-86. Unique Identifier : AIDSLINE MED/95336690; Riddell SR; Greenberg PD; Program in Immunology, Fred Hutchinson Cancer Research Center,; Seattle, Washington 98104, USA.; The development of successful adoptive immunotherapy for human virus infections is predicated on an understanding of the effector cells and mechanisms essential for providing the host with a protective response to acute infection and the requirements for long-term in vivo survival of transferred cells that will be nec
The negative attitudes of some general nurses towards drug misusers.: Nurs Stand. 1995 May 17-23;9(34):36-8. Unique Identifier : AIDSLINE MED/95336899; Carroll J; This article presents some findings from an interview study which examined the attitudes of 82 healthcare professionals towards drug misuse and drug misusers. They represented a sub-sample of a larger study of 248 professionals working with intravenous drug misusers in west Scotland. It was thought that nurses attitu
Infection control: a survey to determine knowledge of nurses in a clinical setting.: Nurs Stand. 1995 May 31-Jun 6;9(36):35-8. Unique Identifier : AIDSLINE MED/95336913; Gould D; This study set out to discover whether nurses with an understanding of the theoretical principles of microbiology know more about the clinical aspects of infection control than those without. Two vignettes were developed depicting typical situations. They were presented to 130 nurses in intensive care, surgical or med
'No compulsory HIV tests'.: Nurs Stand. 1995 Jun 7-13;9(37):17. Unique Identifier : AIDSLINE MED/95336923; Young N
Interaction of human immunodeficiency virus type 1 Tat-derived peptides with TAR RNA.: Biochemistry. 1995 Jul 11;34(27):8885-95. Unique Identifier : AIDSLINE MED/95337110; Long KS; Crothers DM; Department of Chemistry, Yale University, New Haven, Connecticut; 06511, USA.; Basic peptides from the carboxy terminus of the human immunodeficiency virus type 1 (HIV-1) Tat protein bind to the stem-loop region of TAR RNA, spanning a trinucleotide bulge, with high affinity and moderate specificity. Previous studies have demonstrated that TAR RNA contains a specific arginine binding pocket. A se
School-based AIDS education for adolescents.: J Adolesc Health. 1995 Apr;16(4):309-15. Unique Identifier : AIDSLINE MED/95337117; Sunwood J; Brenman A; Escobedo J; Philpott T; Allman K; Mueller J; Jaeger J; Brown LK; Cole FS; Office of the Associate Dean for Student Affairs, Washington; University School of Medicine, St. Louis, Missouri, USA.; PURPOSE: To describe a program which utilizes medical students and persons with AIDS (PWAs) to provide for adolescents school-based education about acquired immunodeficiency syndrome (AIDS). METHODS: Two 1.5 hour classroom sessions were conducted by medical students and persons with AIDS for seventh and eighth grade s
HIV prevention beliefs among urban African-American youth.: J Adolesc Health. 1995 Apr;16(4):316-23. Unique Identifier : AIDSLINE MED/95337118; Stevenson HC; Davis G; Weber E; Weiman D; Abdul-Kabir S; University of Pennsylvania, Graduate School of Education,; Psychology in Education Division, Philadelphia 19104-6216, USA.; PURPOSE: This study investigates specific beliefs related to prevention of AIDS and HIV infection among African-American teenagers. METHODS: This study administered valid and reliable measures of HIV/AIDS risk knowledge and prevention beliefs to 150 African-American teenagers. Demographic and psychosocial data were ga
Conformation and stability of recombinant HIV-1 capsid protein p24 (rp24).: Biochim Biophys Acta. 1995 Jul 3;1250(1):9-18. Unique Identifier : AIDSLINE MED/95337139; Misselwitz R; Hausdorf G; Welfle K; Hohne WE; Welfle H; Institute of Biochemistry, Medical Faculty (Charite), Humboldt; University, Berlin, Germany.; Conformation and stability of the recombinant protein HIV-1 rp24 were analyzed by circular dichroism, fluorescence spectroscopy and differential scanning calorimetry under different solvent conditions. From circular dichroism measurements, HIV-1 rp24 at pH 5.8 can be classified as an all alpha-helical protein. A fluor
Isolation and quantitation of human immunodeficiency virus type 1 (HIV-1) from peritoneal dialysate: implications for infection control [letter]: Perit Dial Int. 1995;15(2):179-80. Unique Identifier : AIDSLINE MED/95337228; Breyer JA; Harbison MA
Surgical pathology of pulmonary infections.: Semin Thorac Cardiovasc Surg. 1995 Apr;7(2):62-9. Unique Identifier : AIDSLINE MED/95337241; Travis WD; Department of Pulmonary and Mediastinal Pathology, Armed Forces; Institute of Pathology, Washington, DC 20306-6000, USA.; The evaluation of pulmonary specimens plays an important role in the diagnosis of pulmonary infections. In order to maximize the information gained from each specimen, an organized approach is important to decide when to investigate, what type of specimen to obtain, and from where to obtain the specimen. Careful thoug
Pulmonary infection in the immunocompromised patient.: Semin Thorac Cardiovasc Surg. 1995 Apr;7(2):78-87. Unique Identifier : AIDSLINE MED/95337243; White DA; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021, USA.; Pneumonia in the immunocompromised patient remains a significant cause of morbidity and mortality. These patients are susceptible to a wide variety of organisms, but specific infections tend to occur in well defined settings. The type of infection can be predicted based on the nature and severity of the immune defect,
Viral pulmonary infections in thoracic and cardiovascular surgery.: Semin Thorac Cardiovasc Surg. 1995 Apr;7(2):88-94. Unique Identifier : AIDSLINE MED/95337244; Avery RK; Longworth DL; Department of Infectious Diseases, Cleveland Clinic Foundation, 1; Clinic Center, OH 44195, USA.; Viral respiratory infections are uncommon causes of pulmonary infiltrates in immunocompetent patients who undergo cardiothoracic surgery. In winter months, however, influenza can be acquired in the community preoperatively or in the hospital setting. The recognition of influenza cases is essential to prevent nosocomia
The endemic mycoses: surgical considerations.: Semin Thorac Cardiovasc Surg. 1995 Apr;7(2):95-103. Unique Identifier : AIDSLINE MED/95337245; Johnson PC; Sarosi GA; Department of Internal Medicine, The University of Texas Medical; School, Houston, USA.; Surgical consultation is regularly requested for diagnosis and treatment of pulmonary complications of the endemic mycosis, Histoplasma capsulatum, Blastomyces dermatitidis and Coccidioidomycosis immitis, and the yeast Cryptococcus neoformans. All resemble pulmonary malignancies. Histoplasmosis causes pericarditis, me
Role of laparoscopic surgery in the management of acute abdomen in the HIV-positive patients.: J Laparoendosc Surg. 1995 Apr;5(2):101-4. Unique Identifier : AIDSLINE MED/95337432; Bouillot JL; Dehni N; Kazatchkine M; Fernandez F; Piketti C; Salah S; Alexandre JH; Department of General Surgery, University Paris VI, Hospital; Broussais, France.; Emergency open laparotomy in patients infected with HIV is accompanied by high mortality. The authors investigated the potential role of a laparoscopic approach for the management of acute abdomen in such patients. Prospectively, 10 patients with HIV disease (9 with AIDS) underwent laparoscopy for acute abdomen. The t
Immunopathogenesis of dilated cardiomyopathies.: Curr Opin Cardiol. 1995 May;10(3):306-11. Unique Identifier : AIDSLINE MED/95337536; Goldman JH; McKenna WJ; Department of Cardiological Sciences, St. George's Hospital; Medical School, London, UK.; Idiopathic dilated cardiomyopathy is a chronic heart muscle disorder of unknown etiology, but experimental and clinical evidence is accumulating that points to an immune pathogenesis in a subset of patients, and to the potential importance of myosin as an antigen. Most recent developments include evidence of cardiac-
The natural history and spectrum of idiopathic dilated cardiomyopathy, including HIV and peripartum cardiomyopathy.: Curr Opin Cardiol. 1995 May;10(3):332-8. Unique Identifier : AIDSLINE MED/95337539; Cetta F; Michels VV; A-1 Echo Laboratory, Mayo Clinic, Rochester, MN 55905, USA.; Idiopathic dilated cardiomyopathy (IDCM) is an often fatal heart disease characterized by ventricular dilation and reduced systolic function. Despite advances in diagnostic and therapeutic techniques that have enabled earlier identification of patients with IDCM, the etiology of the disease in most patients remains un
Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):115-8. Unique Identifier : AIDSLINE MED/95337697; Kips JC; Brusselle GG; Joos GF; Peleman RA; Devos RR; Tavernier JH; Pauwels RA; Department of Respiratory Diseases, University Hospital Ghent,; Belgium.; T helper 2 (Th2)-like cells are thought to play a crucial role in the pathogenesis of atopic asthma. In this study, we attempted to evaluate the in vivo effect of suppressing Th2 cell development on allergen-induced airway changes. Repeated exposure of actively sensitized C57Bl/6 mice to aerosolized ovalbumin (OA) cau
Staphylococcal enterotoxin B affects in vitro IgE synthesis, interferon-gamma, interleukin-4 and interleukin-5 production in atopic eczema.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):179-82. Unique Identifier : AIDSLINE MED/95337721; Neuber K; Steinrucke K; Ring J; Department of Dermatology and Allergology, University Hospital; Hamburg, Germany.; Peripheral blood mononuclear cells from patients with atopic eczema (AE) stimulated with the superantigen Staphylococcus enterotoxin B (SEB) secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE, and markedly less interferon-gamma than those from healthy controls. Our results support the assumption
Interleukin-4 and interferon-gamma regulate differentiation of CD8+ T cells into populations with divergent cytokine profiles.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):186-8. Unique Identifier : AIDSLINE MED/95337723; Noble A; Kemeny DM; Department of Allergy and Respiratory Medicine, Guy's and St; Thomas's Hospital, London, UK.; The ability of CD8+ T cells to synthesise and secrete cytokines before and after culture with interleukin (IL)-4 and anti-interferon (IFN)-gamma was investigated. Purified rat splenic CD8+ and CD4+ T cells and CD4-CD8- cells were stimulated with phorbol myristate acetate (PMA) and ionomycin for 6 h and expression of m
A conserved motif in the promoters of several cytokines expressed by human Th2-type lymphocytes.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):217-9. Unique Identifier : AIDSLINE MED/95337734; Staynov DZ; Cousins DJ; Lee TH; Department of Allergy and Respiratory Medicine, UMDS, Guy's; Hospital, University of London, UK.; We have recently found a novel conserved motif in the promoters of several T-cell-expressed cytokines [human interleukin-2, -4, 5 and -13 and human and mouse granulocyte/macrophage-colony stimulating factor (GM-CSF)]. It contains a core sequence CTTGG ... CCAAG which is present as part of larger palindromic sequences
Genetic basis of IgE responsiveness: relevance to the atopic diseases.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):25-8. Unique Identifier : AIDSLINE MED/95337746; Marsh DG; Neely JD; Breazeale DR; Ghosh B; Freidhoff LR; Schou C; Beaty TH; Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224,; USA.; Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negati
Peptide-mediated immunoregulation.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):275-7. Unique Identifier : AIDSLINE MED/95337754; Hetzel C; Hoyne GF; Lamb JR; Department of Biology, Imperial College of Science, Technology; and Medicine, London, UK.; Quantitative and qualitative characteristics of the signals received by a T cell determine whether receptor ligation results in cell activation, cell death, or the induction of antigen-specific non-responsiveness. Environmental factors such as the nature of costimulation, antigen-presenting cell type, peptide structur
Humoral immune responses to recombinant tree pollen allergens (Bet v I and Bet v II) in mice: construction of a live oral allergy vaccine.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):290-4. Unique Identifier : AIDSLINE MED/95337759; Vrtala S; Grote M; Ferreira F; Susani M; Stocker B; Kraft D; Valenta R; Institute of General and Experimental Pathology, AKH, University; of Vienna, Austria.; Recombinant tree pollen allergens (recombinant Bet v I and recombinant birch profilin, Bet v II) were purified and used to immunize BALB/c and B6D2F1 mice with Al(OH)3 to elicit a specific IgE response. Serum from immunized mice was then used to detect immunoblotted natural tree pollen allergens. The onset of the humo
Cytokine production by highly purified human CD8+ T cells.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):354-5. Unique Identifier : AIDSLINE MED/95337785; Li Y; Richards D; Noble A; Kemeny DM; Department of Allergy and Respiratory Medicine, Guy's and St.; Thomas's Hospital, London, UK.; We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe
Pharmacologic modulation of Th1 and Th2 cell subsets by nedocromil sodium.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):414-5. Unique Identifier : AIDSLINE MED/95337816; Farrar JR; Rainey DK; Norris AA; Educational Services, Fisons Pharmaceuticals, Rochester, NY; 14603, USA.
Roxithromycin: its effects on concanavalin-A induced spleen cell proliferation and interleukin production in mice.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):427. Unique Identifier : AIDSLINE MED/95337824; Adachi M; Konno S; First Department of Internal Medicine, School of Medicine, Showa; University, Tokyo, Japan.
Vernal keratoconjunctivitis: a model of 5q cytokine gene cluster disease.: Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):95-8. Unique Identifier : AIDSLINE MED/95337860; Bonini S; Bonini S; Lambiase A; Magrini L; Rumi C; Del Prete G; Schiavone M; Rotiroti G; Onorati P; Rutella S; Chair of Clinical Immunology and Allergology, Second University; of Naples, Italy.; Clinical studies of vernal keratoconjunctivitis (VKC) patients show that total IgE serum levels are increased even in the absence of IgE antibodies to common allergens. Activated eosinophils are also a constant feature of VKC at both the circulation (cytofluorimetry) and tissue (tear cytology and conjunctival scraping
Renault's boss is investigated in blood scandal [news]: BMJ. 1995 Jun 3;310(6992):1428-9. Unique Identifier : AIDSLINE MED/95337908; Dorozynski A
Out of control.: BMJ. 1995 Jun 3;310(6992):1475. Unique Identifier : AIDSLINE MED/95337947; Rigby R
HIV positive patients first presenting with an AIDS defining illness: characteristics and survival [published erratum appears in BMJ 1995 Aug 5;311(7001):356]: BMJ. 1995 Jul 15;311(6998):156-8. Unique Identifier : AIDSLINE MED/95338079; Poznansky MC; Coker R; Skinner C; Hill A; Bailey S; Whitaker L; Renton A; Weber J; Department of Genitourinary Medicine and Communicable Diseases,; St Mary's Hospital Medical School, London.; OBJECTIVES--To study the presentation and survival of patients who present with their first diagnosis of being HIV positive at the same time as their AIDS defining illness. DESIGN--Retrospective study of patients presenting with AIDS between 1991 and 1993. SETTING--Department of genitourinary medicine, St Mary s Hospi
The role of spleen in the pathogeny of aplastic anemia related to increased number of CD3+ CD8+ FcR+ cells.: Rom J Intern Med. 1994 Oct-Dec;32(4):275-82. Unique Identifier : AIDSLINE MED/95338161; Roman S; Grigoriu G; Puscariu T; Fagarasanu D; Berceanu S; Center of Immunology, St. Nicolau Institute of Virology,; Bucharest, Romania.; The role of spleen in the pathogeny of aplastic anemia (A.A.) related to excessive suppression, and the value of splenectomy in the treatment of this disorder is still debated and unclear. In an attempt to find out why some patients respond to surgery and others do not, an immunologic study was carried out in 16 patie
The Bristol-Myers Anorexia/Cachexia Recovery Instrument (BACRI): a brief assessment of patients' subjective response to treatment for anorexia/cachexia.: Qual Life Res. 1995 Jun;4(3):221-31. Unique Identifier : AIDSLINE MED/95338196; Cella DF; VonRoenn J; Lloyd S; Browder HP; Division of Psychosocial Oncology, Rush Cancer Institute,; Chicago, IL 60612, USA.; A brief visual analogue instrument was developed and tested in the context of a multicentre randomized double-blinded four-dose trial of megestrol acetate for the treatment of AIDS-related anorexia/cachexia. This nine-item instrument, the Bristol-Myers Anorexia/Cachexia Recovery Instrument (BACRI), was administered ev
Progressive interstitial lung disease in a 75 year old woman.: Monaldi Arch Chest Dis. 1995 Apr;50(2):118-22. Unique Identifier : AIDSLINE MED/95338208; Kummer F; Salzmann H; Wieckowski A; Second Medical and Lung Dept, Wilhelminenspital der Stadt Wien,; Vienna.; The case of a 75 year old woman with rapidly progressive interstitial lung disease is presented. Bronchoalveolar lavage (BAL) was consistent with CD8+ cell alveolitis, and computerized tomography revealed features of bronchiolitis obliterans organizing pneumonia (BOOP). The patient had been on clomipramine (a tricycli
AIDS and HIV-1 infection worldwide.: Commun Dis Rep CDR Wkly. 1995 May 19;5(20):97-8. Unique Identifier : AIDSLINE MED/95338282
Children whose mothers are infected with HIV.: Commun Dis Rep CDR Wkly. 1995 Jun 16;5(24):111. Unique Identifier : AIDSLINE MED/95338284
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1995 Jun 16;5(24):115-6. Unique Identifier : AIDSLINE MED/95338286
Induction of MMP9 (92 kDa gelatinase) activity and expression of tissue inhibitor of metalloproteinase-2 mRNA (TIMP-2) in primitive neuroectodermal cells infected with retrovirus HTLV-I.: Eur J Neurosci. 1995 May 1;7(5):841-8. Unique Identifier : AIDSLINE MED/95338326; Giraudon P; Thomasset N; Bernard A; Verrier B; Belin MF; INSERM, Faculte de Medecine A, Lyon, France.; Matrix-degrading proteases, including metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), are involved in modulation of the extracellular matrix, which participates in neural cell differentiation, brain morphogenesis and tissue integrity. Metalloproteinases and TIMPs are associated with infl
Training in infectious disease: planning for the future.: Infect Agents Dis. 1995 Jun;4(2):110-4. Unique Identifier : AIDSLINE MED/95338447; Klempner MS; Langdon LO; Tufts-New England Medical Center, Department of Medicine, Boston,; MA 02111, USA.
Wasting syndrome in AIDS: pathophysiologic mechanisms and therapeutic approaches.: Infect Agents Dis. 1995 Jun;4(2):76-94. Unique Identifier : AIDSLINE MED/95338450; Weinroth SE; Parenti DM; Simon GL; Department of Medicine, George Washington University Medical; Center, Washington, D.C. 20037, USA.; Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever and diarrhea. The pathophysiologic mechanisms responsible for this syndrome are not well defined, but it is clear that this is a multifactorial process in which the relative con
Trial objectives and end points for measuring the efficacy of HIV vaccines.: Infect Agents Dis. 1995 Jun;4(2):95-101. Unique Identifier : AIDSLINE MED/95338451; Hoff R; Barker LF; Vaccine and Prevention Research Program, Division of AIDS,; National Institute of Allergy and Infectious Diseases, NIH,; Bethesda, Maryland 20892, USA.; In order to prove the efficacy of human immunodeficiency virus (HIV) vaccines, it will be necessary to do large-scale trials in populations at high risk of acquiring HIV infection. The choice of objectives and end points and their measurement will be key to the design of efficacy trials. To address these issues, the N
Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor.: Structure. 1995 Apr 15;3(4):381-9. Unique Identifier : AIDSLINE MED/95338600; Priestle JP; Fassler A; Rosel J; Tintelnot-Blomley M; Strop P; Grutter MG; Department of Core Drug Discovery Technologies, Pharma Research,; Ciba-Geigy Ltd., Basel, Switzerland.; BACKGROUND: The human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). Two subtypes of the virus, HIV-1 and HIV-2, have been characterized. The protease enzymes from these two subtypes, which are aspartic acid proteases and have been found to be essential for maturation
Human immunodeficiency virus infection and genital warts as risk factors for anal intraepithelial neoplasia in homosexual men.: Br J Surg. 1995 Apr;82(4):473-4. Unique Identifier : AIDSLINE MED/95338623; Carter PS; de Ruiter A; Whatrup C; Katz DR; Ewings P; Mindel A; Northover JM; ICRF Colorectal Cancer Unit, St Mark's Hospital, London, UK.; The incidence of anal intraepithelial neoplasia (AIN) was studied in a group of 210 homosexual and bisexual men. The presence of genital warts and human immunodeficiency virus (HIV) infection was assessed as risk factors for the development of AIN. In all, 74 (35 per cent) of the group had histological evidence of AIN
[Predictive values of the usual biologic tests for the detection of human immunodeficiency virus infection. Consequences for screening]: Bull Acad Natl Med. 1995 Feb;179(2):317-31; discussion 331-3. Unique Identifier : AIDSLINE MED/95338806; Gremy F; Salmi LR; Universite de Montpellier I, Faculte de Medecine, LUSIEEM,; Hopital Lapeyronie.; This paper tries to review what is scientifically known about the predictive values of biological tests of HIV infection. The epidemiological situation for that infection is characterized by two facts: the very high values of sensitivity and specificity which are close to unity; the prevalence of seropositivity which
Oral hairy leukoplakia in an HIV-negative woman with Behcet's syndrome.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):53-6. Unique Identifier : AIDSLINE MED/95338915; Schiodt M; Norgaard T; Greenspan JS; Department of Oral Surgery, Central Hospital, San Francisco,; Calif., USA.; The first case of oral hairy leukoplakia in an HIV-negative patient with Behcet s syndrome is reported. The patient was a 47-year-old woman with bilateral lesions on the tongue. The clinic and histologic appearances were typical of hairy leukoplakia, and Epstein-Barr virus was demonstrated in the epithelial cells by D
Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):64-7. Unique Identifier : AIDSLINE MED/95338917; Gowdey G; Lee RK; Carpenter WM; HIV CARE Program, University of the Pacific, School of Dentistry,; San Francisco, Calif., USA.; Ten HIV-infected patients who had bilateral hairy leukoplakia on the tongue were treated with topical podophyllum resin 25% solution. Only one side of the bilateral lesion was treated and the other side served as the control and was not treated. The lesions on both the treatment and control sides were evaluated at day
Gingival mass lesions in a patient with HIV infection [clinical conference]: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jan;79(1):7-9. Unique Identifier : AIDSLINE MED/95338919; Gowdey G; Lipsey LR; Lee R; Jacques C; Northfelt DW; HIV CARE Program, University of the Pacific School of Dentistry,; San Francisco, Calif., USA.
Fluconazole response patterns in HIV-infected patients with oropharyngeal candidiasis.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):170-4. Unique Identifier : AIDSLINE MED/95338932; Diz Dios PD; Alvarez Alvarez J; Fernandez Feijoo J; Castro Ferreiro M; Section for Special Patients, School of Dentistry, Santiago de; Compostela University, Spain.; A prospective study to assess the efficacy of fluconazole in oropharyngeal candidiasis in patients with HIV was conducted. A cohort of 30 HIV-positive persons with clinical and microbiologic confirmed oropharyngeal candidiasis (Candida albicans > 1000 CFU/ml) received fluconazole 100 mg daily for 7 days. In vitro anti
Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients.: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):175-9. Unique Identifier : AIDSLINE MED/95338933; Greenberg MS; Dubin G; Stewart JC; Cumming CG; MacGregor RR; Friedman HM; Department of Oral Medicine, School of Dental Medicine,; University of Pennsylvania, Philadelphia, USA.; Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with
Inhibition of HIV-1 by a double transdominant fusion gene.: Gene Ther. 1995 May;2(3):181-6. Unique Identifier : AIDSLINE MED/95339003; Aguilar-Cordova E; Chinen J; Donehower LA; Harper JW; Rice AP; Butel JS; Belmont JW; Department of Pediatrics, Baylor College of Medicine, Houston, TX; 77030, USA.; A double transdominant fusion gene (trev) designed to inhibit two essential HIV functions simultaneously was constructed by linking tat and rev transdominant mutants. Trev independently inhibited both Tat and Rev functions, localized within the nucleus and cells transfected with trev showed a stable inhibition of HIV-
Continuous secretion of human soluble CD4 in mice transplanted with genetically modified cells.: Gene Ther. 1995 May;2(3):197-202. Unique Identifier : AIDSLINE MED/95339005; Valere T; Bohl D; Klatzmann D; Danos O; Sonigo P; Heard JM; Institut Cochin de Genetique Moleculaire (ICGM-CNRS UPR415),; Paris, France.; Somatic transgenesis can be used to confer endogenous production of proteins with therapeutic properties. One such product, recombinant soluble human CD4 (sCD4), has been shown to be an efficient inhibitor of human immunodeficiency virus 1 (HIV-1) in vitro, but its too short half-life in vivo has impaired long-term cl
Antitat gene therapy: a candidate for late-stage AIDS patients.: Gene Ther. 1995 May;2(3):218-22. Unique Identifier : AIDSLINE MED/95339008; Lisziewicz J; Sun D; Lisziewicz A; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255, USA.; Antitat is an autoregulated gene expressing an inhibitory RNA with dual function: it sequesters the Tat protein by polymeric-TAR and blocks the translation of the Tat messenger RNA by antisense-Tat. Using human T cell lines and peripheral blood lymphocytes as the in vitro target, we have previously shown that antitat
AIDS and discrimination [letter; comment]: J Can Dent Assoc. 1995 Jun;61(6):473. Unique Identifier : AIDSLINE MED/95339271; Swaine TJ
The law and ethics in relation to dentists treating HIV-positive patients: two recent court cases.: J Can Dent Assoc. 1995 Jun;61(6):487-91. Unique Identifier : AIDSLINE MED/95339273; Graham PE; Miller NM; Harel-Raviv M; Faculty of Dentistry, McGill University, Montreal, Quebec,; Canada.; Two recent Canadian judgements regarding the application of human rights legislation to dentistry and HIV-seropositive patients are summarized and discussed. In the Ontario case of Jerome v. DeMarco, the Ontario Human Rights tribunal found that seropositivity constitutes a handicap under human rights legislation. Howe
Dentistry and tuberculosis in the 1900s.: J Can Dent Assoc. 1995 Jun;61(6):492, 495-8. Unique Identifier : AIDSLINE MED/95339274; Riben PD; Epstein JB; Mathias RG; Health Facility Epidemiology/Environmental Health, Vancouver; Hospital and Health Sciences Centre.; The number of new cases--or incidence--of tuberculosis is increasing in nearly every region of the world. A number of forces have resulted in the increased incidence of TB in developed countries, including the HIV epidemic, homelessness, and emigration from highly endemic regions. Although the number of new cases in
Compliance to recommended infection control procedures: changes over six years among British Columbia dentists.: J Can Dent Assoc. 1995 Jun;61(6):526-32. Unique Identifier : AIDSLINE MED/95339278; Gibson GB; Mathias RG; Epstein JB; Division of Hospital Dentistry, Faculty of Dentistry, University; of British Columbia.; Over the last decade, in response to the heightened awareness of HBV and HIV infections, world health authorities have produced specific infection control recommendations for dental practices. Surveys have been done in various countries to investigate the level of compliance to these recommendations. This paper report
New AIDS data [news]: Can Med Assoc J. 1995 Aug 1;153(3):319. Unique Identifier : AIDSLINE MED/95339290
The ratio of AIDS to non-AIDS Medicaid medical costs from 1992 to 2000.: Clin Ther. 1995 Mar-Apr;17(2):320-9. Unique Identifier : AIDSLINE MED/95339383; Kotzan JA; McMillan CA; Pharmacy Care Administration, University of Georgia, Athens, USA.; Our research objective was to calculate and forecast the monthly increase in medical and prescription costs for Medicaid patients with acquired immunodeficiency syndrome (AIDS) and compare these values with costs for non-AIDS patients. A retrospective analysis of AIDS patients and a control group of
Therapeutic algorithms for the management of sexually transmitted diseases at the peripheral level in Cote d'Ivoire: assessment of efficacy and cost.: Bull World Health Organ. 1995;73(3):305-13. Unique Identifier : AIDSLINE MED/95339515; La Ruche G; Lorougnon F; Digbeu N; Programme National de Lutte contre le SIDA/MST de Cote d'Ivoire,; Abidjan.; In the acquired immunodeficiency syndrome (AIDS) era, adequate management of sexually transmitted diseases (STDs) is a primary concern in Africa. Assessed in this study is the clinical efficacy and feasibility of WHO-recommended therapeutic algorithms for genital discharges and ulcers, diagnosed without laboratory tes
Testing for HIV infection among individuals with tuberculosis: a Joint Statement of the WHO Global Tuberculosis Programme and the Global Programme on AIDS [news]: Bull World Health Organ. 1995;73(3):400, 406-7. Unique Identifier : AIDSLINE MED/95339527
Prospects for immunotoxin therapy of non-Hodgkin's lymphoma.: Clin Immunol Immunopathol. 1995 Aug;76(2):107-14. Unique Identifier : AIDSLINE MED/95339601; Grossbard ML; Fidias P; Hematology/Oncology Unit, Massachusetts General Hospital, Boston; 02114, USA.; The use of unconjugated monoclonal antibodies to treat patients with non-Hodgkin s lymphoma by targeting specific antigenic determinants on malignant cells has been an area of intense laboratory and clinical research. Although occasional clinical successes have been seen, many limi
T cells in regenerating feathers of Smyth line chickens with vitiligo.: Clin Immunol Immunopathol. 1995 Aug;76(2):120-6. Unique Identifier : AIDSLINE MED/95339603; Erf GF; Trejo-Skalli AV; Smyth JR Jr; Department of Biological Sciences, Smith College, Northampton,; Massachusetts 01063, USA.; Smyth line (SL) chickens exhibit a spontaneous, autoimmune, depigmentation (SL vitiligo, SLV) in regenerating feather tissue due to the death of pigment cells (melanocytes). It was the purpose of this study to characterize mononuclear leukocytes which infiltrate the feather as SLV develops. Frozen sections of regenera
Determination of CD4+ and CD8+ lymphocytes with the cytosphere assay: a comparative study with flow cytometry and the immunoalkaline phosphatase method.: Clin Immunol Immunopathol. 1995 Aug;76(2):135-41. Unique Identifier : AIDSLINE MED/95339605; Gernow A; Lisse IM; Bottiger B; Christensen L; Brattegaard K; Department of Pathology, Hvidovre University Hospital,; Copenhagen, Denmark.; The proportion and absolute numbers of CD4+ and CD8+ lymphocytes in peripheral blood were determined using a new manual method, the cytosphere assay (CA). This method uses small latex beads coated with monoclonal antibodies directed against the CD4 and CD8 receptors, respectively. The CA was compared with two other me
In vitro activation leads to the binding of T-cell markers to the surface of B-lymphocytes.: Clin Immunol Immunopathol. 1995 Aug;76(2):148-54. Unique Identifier : AIDSLINE MED/95339607; Rabinowitz R; Massiah E; Hadar R; Schlesinger M; Hubert H. Humphrey Center for Experimental Medicine, Hebrew; University, Hadassah Medical School, Jerusalem, Israel.; The aim of the present study was to determine whether activation of human T-cells in vitro results in the expression of markers characteristic for T-cells on the surface of B-lymphocytes and to correlate antigenic changes with the release of soluble T-cell antigens. Peripheral blood lymphocytes (PBL) were exposed in v
[Treatment of spastic paraparesis with botulinum toxin with reference to beneficial effects, disease severity and long-term treatment]: Rinsho Shinkeigaku. 1995 Mar;35(3):251-5. Unique Identifier : AIDSLINE MED/95339621; Takenaga S; Kawahigashi Y; Sonoda Y; Horikiri T; Hirata K; Arimura K; Osame M; Third Department of Internal Medicine, Kagoshima University; School of Medicine.; We administered local botulinum toxin injections on the leg adductors of 12 patients with spastic paraparesis (9 patients with HAM, 2 patients with spinal spastic paraparesis, 1 patient with an identified degenerative disease). Two of them were wheelchair-bound and the other patients could walk with or without help. T
Zalcitabine. Clinical pharmacokinetics and efficacy.: Clin Pharmacokinet. 1995 May;28(5):351-60. Unique Identifier : AIDSLINE MED/95339652; Devineni D; Gallo JM; Department of Medical Oncology, Fox Chase Cancer Center,; Philadelphia, Pennsylvania, USA.; Zalcitabine ( ddC ) was the first drug to be approved under the US Food and Drug Administration s (FDA s) accelerated drug approval process. Zalcitabine is a potent nucleoside analogue inhibitor of reverse transcriptase used in the treatment of HIV infe
Patterns of Ga-67 citrate accumulation in human immunodeficiency virus positive patients with and without Mycobacterium avium intracellulare infection.: Clin Radiol. 1995 Jul;50(7):483-8. Unique Identifier : AIDSLINE MED/95339674; Buscombe JR; Buttery P; Ell PJ; Miller RF; Institute of Nuclear Medicine, UCL Medical School, London, UK.; Infection with Mycobacterium avium intracellulaire (MAI) is an increasingly important problem in patients infected with Human Immunodeficiency Virus (HIV). The objective of this study was to identify whether specific patterns of accumulation of Ga-67 citrate occur in HIV antibody positive patients with disseminated MA
Perspectives in drug therapy of HIV infection.: Drugs. 1995;49 Suppl 1:1-3; discussion 38-40. Unique Identifier : AIDSLINE MED/95339778; Darbyshire J; Medical Research Council HIV Clinical Trials Centre, University; College London Medical School, England.; Current key issues in the drug therapy of HIV infection include the timing of treatment initiation, the use of multiple-drug therapy and the duration of treatment. Although most clinicians agree that symptomatic HIV disease should be treated, there is no consensus as to whether patients should be treated before sympto
Prevention of maternal HIV transmission. Practical guidelines.: Drugs. 1995;49 Suppl 1:17-24; discussion 38-40. Unique Identifier : AIDSLINE MED/95339779; Rouzioux C; Hopital Necker-Enfants Malades, Paris, France.; The recently published Protocol 076 study (ACTG 076/ANRS 024) showed that zidovudine significantly decreased the relative risk of maternal HIV transmission by 71.5% compared with placebo. Oral zidovudine 100 mg five times daily until the onset of labour, followed by intravenous zidovudine 2 mg/kg over 1 hour then 1 mg
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC).: Drugs. 1995;49 Suppl 1:25-31; discussion 38-40. Unique Identifier : AIDSLINE MED/95339780; Portegies P; Academic Medical Centre, University of Amsterdam, The; Netherlands.; Following the introduction of zidovudine, a major decline was noted in the incidence of AIDS dementia complex (ADC). Several factors point to a causal relationship. It is important now to review the evidence derived from clinical, cerebrospinal fluid (CSF) and neuropathological stu
Combination antiretroviral therapy. Back to the future.: Drugs. 1995;49 Suppl 1:32-7; discussion 38-40. Unique Identifier : AIDSLINE MED/95339781; Lange J; Academic Medical Centre, University of Amsterdam, The; Netherlands.; HIV causes chronic infection and is associated with persistent viral replication and a high viral mutation rate. It is an illusion to think that monotherapy with any antiretroviral agent will have a major and lasting impact on this disease. Monotherapy with antitubercular agents led to dramatic improvements in treatme
The value of the CD4+ count of 500 cells/microliters.: Drugs. 1995;49 Suppl 1:4-8; discussion 38-40. Unique Identifier : AIDSLINE MED/95339782; Volberding P; AIDS Program, San Francisco General Hospital, California, USA.; The CD4+ cell count is a surrogate marker used for evaluating the efficacy of therapies for HIV infection and for estimating the prognosis of patients with HIV infection. However, there is no single CD4+ count that can be used to indicate likely clinical outcome or the optimal time of treatment initiation. Protocol 01
Early versus delayed treatment of HIV infection. Zidovudine should be given before symptoms develop.: Drugs. 1995;49 Suppl 1:9-16; discussion 38-40. Unique Identifier : AIDSLINE MED/95339783; Richman DD; Havlir D; Department of Pathology, University of California San Diego, La; Jolla, USA.; An understanding of the virology and pathogenesis of HIV infection provides a rationale for initiating early intervention with antiretroviral drugs. Even at the earliest stages of infection when HIV-infected patients are asymptomatic, viral replication is ongoing, particularly in lymphoid tissues. Initiation of antire
Evaluation of the relatedness of strains of Mycobacterium avium using pulsed-field gel electrophoresis.: Eur J Clin Microbiol Infect Dis. 1995 Mar;14(3):212-7. Unique Identifier : AIDSLINE MED/95339844; Burki DR; Bernasconi C; Bodmer T; Telenti A; Institute for Medical Microbiology, University of Berne,; Switzerland.; The application of molecular techniques to investigate strain relatedness may help define the local epidemiology of Mycobacterium avium infection, and, by identifying false isolates (i.e. neither pathogens nor colonizers) resulting from contamination, may serve as a tool for quality control in the laboratory. For this
A case of disseminated Mycobacterium bovis infection in an AIDS patient.: Eur J Clin Microbiol Infect Dis. 1995 Mar;14(3):226-9. Unique Identifier : AIDSLINE MED/95339847; Albrecht H; Stellbrink HJ; Eggers C; Rusch-Gerdes S; Greten H; Medizinische Kernklinik, Universitatskrankenhaus Eppendorf,; Hamburg, Germany.; The first case of disseminated Mycobacterium bovis infection with meningitis in an AIDS patient is reported. A 54-year-old male HIV-positive patient was admitted for evaluation of fever, weight loss, inappetence, fatigue and malaise. Mycobacterium bovis (non-BCG) was isolated from blood, bone marrow, stool, urine, spu
Selective variations in vivo of VH3 and VH1 gene family expression in peripheral B cell IgM, IgD and IgG during HIV infection.: Eur J Immunol. 1995 Jun;25(6):1524-8. Unique Identifier : AIDSLINE MED/95339862; David D; Demaison C; Bani L; Zouali M; Theze J; Departement d'Immunologie, Institut Pasteur, Paris, France.; We have analyzed the expression of VH gene families in IgM, IgD and IgG of peripheral blood B cells from a group of HIV-infected patients. CD19+CD20+ cells were purified and anchored reverse transcriptase-polymerase chain reaction products were hybridized with VH gene family probes. IgM, IgD and IgG that expressed a V
Vitamin A deficiency results in a priming environment conducive for Th1 cell development.: Eur J Immunol. 1995 Jun;25(6):1673-9. Unique Identifier : AIDSLINE MED/95339883; Cantorna MT; Nashold FE; Hayes CE; Department of Biochemistry, University of Wisconsin-Madison; 53706, USA.; Certain infections, like that with the human immunodeficiency virus-1, deplete vitamin A, and when vitamin A levels are low, immune dysfunctions establish susceptibility to further infection. Our research has focused on the immune dysfunctions that are a consequence of vitamin A deficiency and that predispose to furth
Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes.: Eur J Immunol. 1995 Jun;25(6):1744-8. Unique Identifier : AIDSLINE GENBANK/X86474; Muller S; Dorner B; Korthauer U; Mages HW; D'Apuzzo M; Senger G; Kroczek RA; Molecular Immunology, Robert-Koch-Institute, Berlin, Germany.; A cDNA clone, designated ATAC, was isolated from a collection of human T cell activation genes. Analysis of tissue distribution determined that ATAC mRNA of approximately 0.9 kb is exclusively expressed in activated CD8+ T cells. Induction of the ATAC gene requires stimulation by both phorbol 12-myristate 13-acetate a
gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor.: Eur J Immunol. 1995 Jun;25(6):1778-82. Unique Identifier : AIDSLINE MED/95339898; Foster S; Beverley P; Aspinall R; Department of Medicine, St. Mary's Hospital Medical School,; London, GB.; In most individuals, HIV infection is characterized by a progressive decline in the number of peripheral blood CD4+ T lymphocytes, and while the number of CD4+ cells is within the normal range, defects in immune function are detectable. To date neither the decline in function nor the decline in cell number have been s
Induction of peptide-specific primary cytotoxic T lymphocyte responses from human peripheral blood.: Eur J Immunol. 1995 Jun;25(6):1783-7. Unique Identifier : AIDSLINE MED/95339899; Plebanski M; Allsopp CE; Aidoo M; Reyburn H; Hill AV; Nuffield Department of Medicine, University of Oxford, John; Radcliffe Hospital, GB.; Various protocols were developed and compared for eliciting specific cytotoxic T lymphocyte (CTL) cell lines from the unselected human peripheral blood mononuclear cells of naive donors. Interleukin-7 and CD4+ T cells primed in vitro by keyhole limpet hemocyanin were shown to act together in the generation of these re
Evidence for involvement of activated CD8+/HLA-DR+ cells in the pathogenesis of neutropenia in patients with B-cell chronic lymphocytic leukaemia.: Eur J Haematol. 1995 Jul;55(1):33-41. Unique Identifier : AIDSLINE MED/95339939; Katrinakis G; Kyriakou D; Alexandrakis M; Sakellariou D; Foudoulakis A; Eliopoulos GD; Division of Haematology, University of Crete School of Medicine,; University Hospital of Heraklion, Greece.; B-cell chronic lymphocytic leukaemia (B-CLL) is often associated with peripheral blood cytopenias resulting, in most cases, from bone marrow infiltration, hypersplenism, or circulating autoantibodies. The present study was undertaken to investigate the possible involvement of a cell-mediated suppression of granulopoie
[Large-cell anaplastic malignant CD30/Ki-1-positive T-type lymphoma, associated with STLV-1 virus (baboon malignant lymphoma model]: Gematol Transfuziol. 1995 Jan-Feb;40(1):10-6. Unique Identifier : AIDSLINE MED/95340156; Iakovleva LA; Indzhiia LV; Chikobava MG; Demenkova NP; Klotts IN; Shettsl' G; Deinkhardt F; Lapin BA; Medical Microbiology and Hygiene Institute, Munchen, Germany.; Large-cell anaplastic malignant lymphoma of T-type (T-LCAL) as an original form among human non-Hodgkin s malignant lymphomas in Updated Kiel Classification (1988) was defined. In human pathology T-LCAL presents a considerable diagnostic difficulties and is not associated with HTLV except some cutaneous forms. Compara
[Activation of immune cells in sarcoidosis: immunopathogenic and clinical implications]: Immun Infekt. 1995 Jun;23(3):80-5. Unique Identifier : AIDSLINE MED/95340245; Muller-Quernheim J; Medizinische Klinik, Forschungsinstitut Borstel.; Sarcoidosis is a frequent, systemic, granulomatous disorder with predominant involvement of the hilar lymph nodes and the pulmonary parenchyma. By bronchoalveolar lavage an activation of alveolar immune cells has been observed yielding a detailed concept of the immunopathogenesis of the disease from which new, clinica
Illness cognition of HIV-infected mothers.: Issues Ment Health Nurs. 1995 Jul-Aug;16(4):327-44. Unique Identifier : AIDSLINE MED/95340325; Regan-Kubinski MJ; Sharts-Hopko N; Despite the increasing prevalence of human immunodeficiency virus (HIV) infection in the female population the responses of women to their HIV-positive status and their resultant needs remain largely unexplored. This investigation explored the needs, choices, and decisions faced by 38 mothers since becoming HIV-positi
The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration.: J Biol Chem. 1995 Jul 21;270(29):17081-6. Unique Identifier : AIDSLINE MED/95340485; Ryan TC; Cruikshank WW; Kornfeld H; Collins TL; Center DM; Pulmonary Center, Boston University School of Medicine,; Massachusetts 02118, USA.; Lymphocyte chemoattractant factor (LCF) is a polypeptide cytokine which induces both cell motility and activation of T lymphocytes. These LCF-induced events demonstrate an absolute requirement for the cell surface expression of CD4. Because many CD4-mediated T lymphocyte activation events have been demonstrated to req
DNA fingerprinting and phenotyping of Mycobacterium tuberculosis isolates from human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients in Tanzania.: J Clin Microbiol. 1995 May;33(5):1064-9. Unique Identifier : AIDSLINE MED/95340721; Yang ZH; Mtoni I; Chonde M; Mwasekaga M; Fuursted K; Askgard DS; Bennedsen J; de Haas PE; van Soolingen D; van Embden JD; et al; Mycobacteria Department, Statens Seruminstitut, Copenhagen,; Denmark.; With the purpose of determining whether the risk of infection with a particular clone of Mycobacterium tuberculosis is influenced by the human immunodeficiency virus (HIV) status of the host, we analyzed and compared 68 mycobacterial isolates obtained from HIV-seropositive patients with tuberculosis (TB) in Dar es Sal
Genomic fingerprinting of Bartonella species by repetitive element PCR for distinguishing species and isolates.: J Clin Microbiol. 1995 May;33(5):1089-93. Unique Identifier : AIDSLINE MED/95340726; Rodriguez-Barradas MC; Hamill RJ; Houston ED; Georghiou PR; Clarridge JE; Regnery RL; Koehler JE; Section of Infectious Diseases, Medical Service, Veterans Affairs; Medical Center, Houston, TX 77030, USA.; Repetitive-element PCR (rep-PCR) with primers based on repetitive extragenic palindromic (REP) and enterobacterial repetitive intergenic consensus (ERIC) repeated DNA sequences was used for genomic finger-printing of Bartonella species. This technique was applied by using either extracted genomic DNA or preparations o
Cluster of oral atypical Candida albicans isolates in a group of human immunodeficiency virus-positive drug users.: J Clin Microbiol. 1995 May;33(5):1129-35. Unique Identifier : AIDSLINE MED/95340733; Boerlin P; Boerlin-Petzold F; Durussel C; Addo M; Pagani JL; Chave JP; Bille J; Institute of Microbiology, University Hospital, CHUV-BH19SUD,; Lausanne, Switzerland.; Twenty-one chlamydospore-forming and germ tube-positive Candida albicans clinical isolates from 15 human immunodeficiency virus (HIV)-positive and 3 HIV-negative patients were examined by two different genetic methods. Multilocus enzyme electrophoresis and hybridization with the C. albicans-specific Ca3 probe showed t
PCR and in vitro cultivation for detection of Leishmania spp. in diagnostic samples from humans and dogs.: J Clin Microbiol. 1995 May;33(5):1145-9. Unique Identifier : AIDSLINE MED/95340736; Mathis A; Deplazes P; Institute of Parasitology, University of Zurich, Switzerland.; A PCR assay for the diagnosis of leishmaniosis was developed by using primers that were selected from the sequence of the small-subunit rRNA gene. The assay was optimized for routine diagnostic use. Processing of the clinical samples is rapid and simple (lysis of erythrocytes in Tris-EDTA buffer, digestion with protei
Detection of Aspergillus species DNA in bronchoalveolar lavage samples by competitive PCR.: J Clin Microbiol. 1995 May;33(5):1164-8. Unique Identifier : AIDSLINE GENBANK/L37095; Bretagne S; Costa JM; Marmorat-Khuong A; Poron F; Cordonnier C; Vidaud M; Fleury-Feith J; Laboratoire de Parasitologie-Mycologie, Hopital Henri Mondor,; Creteil, France.; A competitive PCR assay involving the use of bronchoalveolar lavage (BAL) samples for the diagnosis of invasive pulmonary aspergillosis (IPA) was developed. For this purpose, a 1-kb mitochondrial DNA fragment of Aspergillus fumigatus was sequenced. The primers used allowed amplification of A. fumigatus, A. flavus, A.
Molecular typing of Candida albicans in oral candidiasis: karyotype epidemiology with human immunodeficiency virus-seropositive patients in comparison with that with healthy carriers.: J Clin Microbiol. 1995 May;33(5):1238-42. Unique Identifier : AIDSLINE MED/95340753; Lupetti A; Guzzi G; Paladini A; Swart K; Campa M; Senesi S; Dipartimento di Biomedicina, Sperimentale Infettiva e Pubblica,; Universita degli Studi di Pisa, Italy.; Candida albicans organisms isolated from the oral cavities of healthy carriers (26 individuals) and compromised hosts (40 human immunodeficiency virus [HIV]-seropositive patients, all showing symptomatic oral candidiasis) were compared by resolving chromosome-sized DNA molecules into electrophoretic karyotypes. Seven-
Stability of free and complexed human immunodeficiency virus type 1 antigen at 4 degrees C and at room temperature.: J Clin Microbiol. 1995 May;33(5):1348-50. Unique Identifier : AIDSLINE MED/95340777; Griffith BP; Garner RB; Chacko TM; Retrovirus Diagnostic Section, National Virology Reference; Laboratory, VA Medical Center, West Haven, Connecticut 06516,; USA.; Free and immune-complex-dissociated (ICD) human immunodeficiency virus type 1 (HIV-1) antigenemias in serum specimens stored at room temperature (RT) and 4 degrees C for 1 to 35 days were evaluated. At all time points examined, there was no significant loss in detectable levels of ICD HIV-1 antigen at either RT or 4 d
Use of restriction fragment length polymorphism as a genetic marker for typing Mycobacterium avium strains.: J Clin Microbiol. 1995 May;33(5):1389-91. Unique Identifier : AIDSLINE MED/95340791; Roiz MP; Palenque E; Guerrero C; Garcia MJ; Departamento de Microbiologia, Hospital Universitario 12 de; Octubre, Madrid, Spain.; Restriction fragment length polymorphism (RFLP) was used to study 75 clinical isolates identified as Mycobacterium avium. Two repetitive insertion sequences, IS1311 and IS900, were used as DNA probes. Although less than 25% of isolates showed RFLP patterns with IS900, all strains gave banding patterns with IS1311. M.
PCR for detection of Pneumocystis carinii in blood cells [letter; comment]: J Clin Microbiol. 1995 May;33(5):1431-2. Unique Identifier : AIDSLINE MED/95340804; Contini C; Cultrera R; Merolla R
Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy.: J Clin Invest. 1995 Jul;96(1):126-31. Unique Identifier : AIDSLINE MED/95340811; Sinnwell TM; Sivakumar K; Soueidan S; Jay C; Frank JA; McLaughlin AC; Dalakas MC; National Institute of Neurological Diseases and Stroke, National; Institutes of Health, Bethesda, Maryland 20892, USA.; Patients on long-term zidovudine ( AZT ) therapy experience muscle fatigue and weakness attributed to AZT-induced mitochondrial toxicity in skeletal muscle. To determine if the clinico-pathological abnormalities in these patients correspond to abnormal
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.: J Clin Invest. 1995 Jul;96(1):456-64. Unique Identifier : AIDSLINE MED/95340855; McNeely TB; Dealy M; Dripps DJ; Orenstein JM; Eisenberg SP; Wahl SM; Laboratory of Immunology, National Institute of Dental Research,; National Institutes of Health, Bethesda, Maryland 20892, USA.; Infection of adherent primary monocytes with HIV-1Ba-L is significantly suppressed in the presence of human saliva. By reverse transcriptase (RT) levels, saliva, although present for only 1 h during monocyte viral exposure, inhibited HIV-1 infectivity for 3 wk after infection, whereas human plasma and synovial fluid f
Immunohistochemical changes in sigmoid colon after allogeneic and autologous bone marrow transplantation.: J Clin Pathol. 1995 Apr;48(4):308-13. Unique Identifier : AIDSLINE MED/95340890; Forbes GM; Erber WN; Herrmann RP; Davies JM; Collins BJ; Department of Gastroenterology, Royal Perth Hospital, Western; Australia.; AIM--To determine whether there are characteristic immunohistological changes in the colonic mucosa in acute graft versus host disease (GvHD). METHODS--Consecutive allogeneic (n = 11) and autologous (n = 11) bone marrow transplant recipients underwent endoscopic biopsy of sigmoid mucosa before transplant and on day 30
Epstein-Barr virus associated lymphoproliferative disorder with fatal involvement of the gastrointestinal tract in an infant.: J Clin Pathol. 1995 Apr;48(4):390-2. Unique Identifier : AIDSLINE MED/95340909; Pan LX; Ramani P; Diss TC; Liang LN; Isaacson PG; Department of Histopathology, University College London Medical; School.; A case of fatal Epstein-Barr virus (EBV) associated lymphoproliferative disorder is reported in an 11 month old female. Heavy infiltrates of CD20 + and EBV EBER mRNA expressing lymphoid blasts were found to cause a series of ulcers along the entire length of the gastrointestinal tract and there was an ileal perforatio
Protection against hospital-acquired tuberculosis, American style: a report on the 4th Annual Meeting of the Society for Hospital Epidemiology of America (SHEA), New Orleans, 1994.: J Hosp Infect. 1995 Mar;29(3):165-8. Unique Identifier : AIDSLINE MED/95340981; Wilcox MH; Clinical Microbiology and Public Health Laboratory, Addenbrooke's; Hospital, Cambridge, UK.
Occupation risk of needlestick injuries among health care personnel in Saudi Arabia.: J Hosp Infect. 1995 Mar;29(3):221-6. Unique Identifier : AIDSLINE MED/95340988; Shanks NJ; al-Kalai D; King Khalid National Guard Hospital, Jeddah, Saudi Arabia.; In a four-year study of penetrating injuries potentially contaminated with blood among health care personnel, the majority of cases occurred amongst nurses (65%). The wards were the commonest place for injury to occur (39%) which questions whether difficult practical procedures should be performed there. Injuries occu
Malignant and normal T cells show random use of T-cell receptor alpha chain variable regions in patients with cutaneous T-cell lymphoma.: J Invest Dermatol. 1995 Jul;105(1):62-4. Unique Identifier : AIDSLINE MED/95341028; Longley J; Tyrrell L; Lu SZ; Farrell J; Ding TG; Yan S; Sallee D; Heald P; Berger C; Tigelaar R; et al; Yale University School of Medicine, Department of Dermatology,; New Haven, CT 06520-8059, USA.; Cutaneous T-cell lymphoma (CTCL) is a malignancy of mature T lymphocytes, most of which express alpha/beta type T-cell receptors (TCRs). The cause of CTCL is unknown, but hypotheses postulating chronic stimulation of TCRs by superantigen or by a leukemogenic virus have been proposed. Either mechanism might produce bia
Human immunodeficiency virus and the skin: selected controversies.: J Invest Dermatol. 1995 Jul;105(1 Suppl):117S-121S. Unique Identifier : AIDSLINE MED/95341040; Duvic M; Department of Dermatology, University of Texas Medical School,; Houston, 77030, USA.; Acquired immunodeficiency syndrome was first recognized as a new disease in 1981 because of the unusual association of Kaposi s sarcoma and Pneumocystis carinii pneumonia in young men. The skin remains one of the most important clinical markers for acquired immunodeficiency syndrome, now recognized as the end stage of
The skin as target, vector, and effector organ in human immunodeficiency virus disease.: J Invest Dermatol. 1995 Jul;105(1 Suppl):122S-126S. Unique Identifier : AIDSLINE MED/95341041; Blauvelt A; Katz SI; Dermatology Branch, National Cancer Institute, Bethesda, Maryland; 20892-1908, USA.; Langerhans cells are CD4+ antigen-presenting cells in the dendritic cell family that can initiate primary and secondary immune responses after emigration from skin and mucosa. Because of these properties, Langerhans cells have been proposed as potential targets for human immunodeficiency virus (HIV) infection and as p
Maturation and migration of cutaneous dendritic cells.: J Invest Dermatol. 1995 Jul;105(1 Suppl):2S-7S. Unique Identifier : AIDSLINE MED/95341043; Steinman R; Hoffman L; Pope M; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, NY 10021, USA.; Dendritic cells have been isolated from the epidermis, dermis, and lymphatics of skin. Cells from each cutaneous compartment can exhibit the distinct morphology, surface phenotype, and strong T-cell-stimulating activity of dendritic cells that are isolated from other organs. Of importance are the mechanisms by which t
Skin-associated lymphoid tissue in human immunodeficiency virus-1, human papillomavirus, and herpes simplex virus infections.: J Invest Dermatol. 1995 Jul;105(1 Suppl):99S-104S. Unique Identifier : AIDSLINE MED/95341060; Memar OM; Arany I; Tyring SK; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555-1019, USA.; The skin-associated lymphoid tissue is composed of keratinocytes, Langerhans cells, skin trophic T cells, and lymphatic endothelial cells of the skin. The epidermis, which is involved in many viral infections, contains all of the components needed for an effective immune response: antigen-presenting Langerhans cells,
Requirements for activation of CD8+ murine T cells. I. Development of cytolytic activity.: Immunol Res. 1994;13(4):215-33. Unique Identifier : AIDSLINE MED/95341106; Cronin DC 2nd; Lancki DW; Fitch FW; Department of Pathology, University of Chicago, IL 60637, USA.; Cytolytic effector function fails to develop if proliferation of allospecific cytolytic T lymphocyte precursors is inhibited, but the requirements for generation of cytolytic activity have not been fully defined. In contrast, the cytolytic effector function of cytolytic T lymphocyte clones does not change during the c
TCR gamma delta cells: mysterious cells of the immune system.: Immunol Res. 1994;13(4):268-79. Unique Identifier : AIDSLINE MED/95341110; Sciammas R; Tatsumi Y; Sperling AI; Arunan K; Bluestone JA; Department of Pathology, Ben May Institute, University of; Chicago, Ill., USA.; Gamma delta cells participate in pathogenic infections and autoimmune conditions, yet, almost a decade after their discovery, little is known regarding their TCR repertoire or effector functions. Unlike MHC-restricted antigen recognition employed by TCR alpha beta cells, TCR gamma delta cells can recognize whole unpro
[A case of amnesia and walking disorder associated with subacute progression of HIV encephalopathy]: Nippon Naika Gakkai Zasshi. 1995 May 10;84(5):798-9. Unique Identifier : AIDSLINE MED/95341150; Fujii T; Sakai H; Takemoto M; Okita H; Takada N; Mihara K; Kuramoto A
Poxvirus-based vaccine candidates for cancer, AIDS, and other infectious diseases.: J Leukoc Biol. 1995 Jul;58(1):1-13. Unique Identifier : AIDSLINE MED/95341166; Perkus ME; Tartaglia J; Paoletti E; Virogenetics Corporation, Rensselaer Technology Park, Troy, NY; 12180, USA.; Over the past 12 years, the poxvirus vector technology has provided scientists with valuable reagents to achieve high-level expression of proteins, to address questions of structure-function relationship of specific polypeptides, to investigate the immunobiology of specific pathogens, and to develop recombinant vaccin
Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production.: J Leukoc Biol. 1995 Jul;58(1):80-9. Unique Identifier : AIDSLINE MED/95341178; Taub DD; Cox GW; Clinical Services Program, Program Resources, Inc., DynCorp,; Frederick, Maryland 21702, USA.; Previous studies have demonstrated that the combination of the T helper cell 1 (Th1)-derived cytokines interleukin (IL)-2 and interferon (IFN)-gamma induces nitric oxide (NO) production and tumor cytolysis by mouse peritoneal macrophages and the mouse macrophage cell line ANA-1 in vitro. Conversely, the Th2-derived cy
Satisfaction with ambulatory care of persons with AIDS: predictors of patient ratings of quality.: J Gen Intern Med. 1995 May;10(5):239-45. Unique Identifier : AIDSLINE MED/95341421; Stone VE; Weissman JS; Cleary PD; Department of Medicine, Boston City Hospital, Boston University; School of Medicine, MA 02118, USA.; OBJECTIVE: To examine the relation of patient characteristics and site of care to the perception of ambulatory care quality by persons with AIDS (PWAs). DESIGN: Patient surveys and medical record review were used to determine PWAs perceptions of their ambulatory care, self-perceived health status, primary care relati
Quality of AIDS care in a changing health care system [editorial]: J Gen Intern Med. 1995 May;10(5):294-5. Unique Identifier : AIDSLINE MED/95341431; Aiken LH
Time- and dose-dependent pharmacokinetics of L-754,394, an HIV protease inhibitor, in rats, dogs and monkeys.: J Pharmacol Exp Ther. 1995 Jul;274(1):264-9. Unique Identifier : AIDSLINE MED/95341504; Lin JH; Chiba M; Chen IW; Vastag KJ; Nishime JA; Dorsey BD; Michelson SR; McDaniel SL; Merck Research Laboratories, West Point, Pennsylvania, USA.; L-754,394 is a potent and specific inhibitor of the HIV-1 encoded protease that is essential for the maturation of the infectious virus. The drug exhibited dose-dependent kinetics in all species studied (rat, dog and monkey); the apparent clearance decreased when the dose was increased. However, the dose-dependency ca
Anti-Human T-lymphotropic virus type-I antibodies in atomic-bomb survivors.: J Radiat Res (Tokyo). 1995 Mar;36(1):8-16. Unique Identifier : AIDSLINE MED/95341594; Matsuo T; Nakashima E; Carter RL; Neriishi K; Mabuchi K; Akiyama M; Shimaoka K; Kinoshita K; Tomonaga M; Ichimaru M; Department of Clinical Studies, Nagasaki Central Hospitals.; Adult T-cell leukemia (ATL), induced by human T- lymphotropic virus type-I (HTLV-I), is endemic in Nagasaki, Japan . To investigate the effects of atomic-bomb radiation on development of this specific type of leukemia, 6182 individuals in the Radiation Effects Research Foundation (RE
Investigation of the structural components governing the polarity-dependent refolding of a CD4-binding peptide from gp120.: J Mol Biol. 1995 Jul 21;250(4):507-13. Unique Identifier : AIDSLINE MED/95341683; Graf von Stosch A; Kinzel V; Pipkorn R; Reed J; Department of Pathochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Federal Republic of Germany.; The conformational switch at the principle CD4-binding domain of gp120 from HIV1 exhibits a highly cooperative folding transition from beta-sheet to helix triggered within a very narrow range of solvent polarity. The physical basis of this folding behaviour is of interest because it is unusual and because it is closel
Experimental treatments flourish for KS patients [news]: J Natl Cancer Inst. 1995 Jul 19;87(14):1052-4. Unique Identifier : AIDSLINE MED/95341708; Nelson NJ
From the Centers for Disease Control and Prevention. HIV transmission in a Dialysis Center--Colombia, 1991-1993.: JAMA. 1995 Aug 2;274(5):372-3. Unique Identifier : AIDSLINE MED/95341736
[Measuring retinal nerve fiber density with laser polarimetry in patients with AIDS in comparison with health probands with reference to computer perimetry findings. A pilot study using the nerve fiber analyzer]: Klin Monatsbl Augenheilkd. 1995 Mar;206(3):165-9. Unique Identifier : AIDSLINE MED/95341844; Thierfelder S; Gramer E; Serguhn S; Universitats-Augenklinik Wurzburg.; BACKGROUND: Several authors postulated a retinal nerve-fiber loss in HIV-infection because of functional alterations (reduced colour sensitivity, alterations in perimetry). This hypothesis has been reevaluated for the first time by means of direct in-vivo measurement of the retinal nerve-fiber-layer thickness by laser
[Treatment of toxoplasmosis retinochoroiditis with atovaquone in an AIDS patient]: Klin Monatsbl Augenheilkd. 1995 Mar;206(3):173-7. Unique Identifier : AIDSLINE MED/95341846; Schimkat M; Althaus C; Armbrecht C; Jablonowski H; Sundmacher R; Augenklinik, Heinrich-Heine-Universitat Dusseldorf.; BACKGROUND: Treatment of ocular toxoplasmosis in HIV-infected patients with standard drug regimens (Pyrimethamine, Clindamycine, Sulfonamides) is very often complicated by side-effects and adverse reactions. On the other hand, maintenance therapy must be continued life long, because of the high recurrence rates. Atova
Benefits of HIV screening of blood transfusions in Zambia [see comments]: Lancet. 1995 Jul 22;346(8969):225-7. Unique Identifier : AIDSLINE MED/95341925; Foster S; Buve A; Department of Public Health and Policy, London School of Hygiene; and Tropical Medicine, UK.; Blood transfusion continues to be an important route of transmission of HIV in developing countries, especially for young children following the perinatal period. Testing for HIV is costly and reliable donor support for the purchase of test kits is often essential, yet difficult to secure. The costs of screening trans
UNAIDS sets preliminary budget [news]: Lancet. 1995 Jul 22;346(8969):239. Unique Identifier : AIDSLINE MED/95341929; McGregor A
IOM criticises US blood product safety procedures [news]: Lancet. 1995 Jul 22;346(8969):243. Unique Identifier : AIDSLINE MED/95341930; Rowe PM
Is it possible to catch leukemia from a cat? [letter; comment]: Lancet. 1995 Jul 22;346(8969):252-3. Unique Identifier : AIDSLINE MED/95341950; Nowotny N; Uthman A; Haas OA; Borkhardt A; Lechner K; Egberink HF; Mostl K; Horzinek MC
Conjunctival malignant disease with AIDS in USA [letter; comment]: Lancet. 1995 Jul 22;346(8969):257-8. Unique Identifier : AIDSLINE MED/95341961; Goedert JJ; Cote TR
Testicular dysfunction in human immunodeficiency virus-infected men.: Metabolism. 1995 Jul;44(7):946-53. Unique Identifier : AIDSLINE MED/95341981; Poretsky L; Can S; Zumoff B; Department of Medicine, Cabrini Medical Center, New York, NY; 10010, USA.; This review pertains to gonadal function in men with human immunodeficiency virus (HIV) infection, who often exhibit clinical and biochemical evidence of hypogonadism. Hypogonadotropic hypogonadism appears to be the most commonly encountered abnormality, although complete anterior pituitary insufficiency and primary g
Tracking the spread of HIV [editorial; comment]: Med J Aust. 1995 Jul 17;163(2):61. Unique Identifier : AIDSLINE MED/95342023; Grulich AE; Kaldor JM
Ascertaining exposure categories of HIV-infected individuals with previously unrecorded risk data [see comments]: Med J Aust. 1995 Jul 17;163(2):66-9. Unique Identifier : AIDSLINE MED/95342026; Stevenson EM; Thompson SC; Crofts N; Epidemiology and Social Research Unit, Macfarlane Burnet Centre; for Medical Research, Melbourne, VIC.; OBJECTIVES: To improve the quality of surveillance data for HIV in Victoria by following up all cases with an unknown exposure category; and to determine whether those with no exposure category included cases of transmission other than via the conventionally recognised routes. METHODS: The Victorian HIV database recor
A comparison of immediate with deferred zidovudine therapy for asymptomatic HIV-infected adults with CD4 cell counts of 500 or more per cubic millimeter. AIDS Clinical Trials Group [see comments]: N Engl J Med. 1995 Aug 17;333(7):401-7. Unique Identifier : AIDSLINE MED/95342190; Volberding PA; Lagakos SW; Grimes JM; Stein DS; Rooney J; Meng TC; Fischl MA; Collier AC; Phair JP; Hirsch MS; et al; University of California, San Francisco, USA.; BACKGROUND. The clinical benefits of zidovudine remain unproved in patients with asymptomatic human immunodeficiency virus (HIV) infection when CD4 cell counts exceed 500 per cubic millimeter. We compared zidovudine therapy given immediately with deferred therapy in such subjects. METHODS. Beginning in 1987, subjects
A controlled trial of zidovudine in primary human immunodeficiency virus infection [see comments] [published erratum appears in N Engl J Med 1995 Nov 16;333(20):1367]: N Engl J Med. 1995 Aug 17;333(7):408-13. Unique Identifier : AIDSLINE MED/95342191; Kinloch-De Loes S; Hirschel BJ; Hoen B; Cooper DA; Tindall B; Carr A; Saurat JH; Clumeck N; Lazzarin A; Mathiesen L; et al; Central Laboratory of Virology, Geneva University Hospital,; Switzerland.; BACKGROUND. It is possible that antiretroviral treatment given early during primary infection with the human immunodeficiency virus (HIV) may reduce acute symptoms, help preserve immune function, and improve the long-term prognosis. METHODS. To assess the effect of early antiviral treatment, we conducted a multicenter
Baboon/man transplant backed for HIV victim [news; comment]: Nature. 1995 Jul 20;376(6537):204. Unique Identifier : AIDSLINE MED/95342223; Lehrman S
Future of AIDS research office threatened [news]: Nature. 1995 Jul 20;376(6537):205-6. Unique Identifier : AIDSLINE MED/95342225; Appel A
Jonas Salk (1914-95) [see comments]: Nature. 1995 Jul 20;376(6537):216. Unique Identifier : AIDSLINE MED/95342230; Dulbecco R; Salk Institute, San Diego, California 92186-5800, USA.
What administrators need to know about the rights of HIV-infected employees.: Nephrol News Issues. 1995 Mar;9(3):18-24. Unique Identifier : AIDSLINE MED/95342250; Riley JB Jr; Pristave RJ
Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia.: Neurosci Lett. 1995 Feb 24;187(1):9-12. Unique Identifier : AIDSLINE MED/95342528; Sardar AM; Reynolds GP; Department of Biomedical Science, University of Sheffield, UK.; HIV-associated dementia is a frequent consequence of HIV infection and relates to neuronal damage, possibly as a result of increased neurotoxic kynurenine metabolites. Indoleamine-2,3-dioxygenase (IDO) activity, which regulates kynurenine metabolism, may thus be increased in HIV in
Multifocal lower genital tract neoplasia in women with HIV disease.: Nurse Pract. 1995 May;20(5):68, 74, 76. Unique Identifier : AIDSLINE MED/95342546; Abercrombie PD; Korn AP; University of California, San Francisco (UCSF), School of; Nursing, USA.; Lower genital tract neoplasia appears to occur often and in multiple sites in women infected with the human immunodeficiency virus (HIV). To describe the prevalence of lower genital tract neoplasia in HIV-infected women in our clinic we performed a retrospective chart review of 38 HIV-infected women who had received s
Relationship between use of condoms and other forms of contraception among human immunodeficiency virus-infected women. Supplement to HIV and AIDS Surveillance Project Group.: Obstet Gynecol. 1995 Aug;86(2):277-82. Unique Identifier : AIDSLINE MED/95342585; Diaz T; Schable B; Chu SY; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia, USA.; OBJECTIVE: To describe the relationship between condom use and use of other contraceptives among human immunodeficiency virus (HIV)-infected women. METHODS: We interviewed 1232 women, 18-50 years of age, who had had sex with a man in the prior 12 months and who were reported with AIDS or HIV to local health department
[Disseminated Pneumocystis carinii infection: clinico-pathologic findings in an AIDS patient]: Pathologica. 1994 Dec;86(6):659-64. Unique Identifier : AIDSLINE MED/95342624; Valdes E; Borzoni F; Onnis D; Piras S; Vespa A; Varsi C; Servizio di Anatomia Patologica, Ospedale SS. Trinita, Cagliari.; Pneumocystis carinii pneumonia (PcP) is the most frequent cause of death in AIDS patients. Systemic diffusion of this microorganism is a rare event, mostly reported in patients receiving prophylactic aerosol therapy. The case here described is relative to a 29 years old man with AIDS, dead short by after hospital admi
Human immunodeficiency virus infections and the respiratory system in children.: Pediatr Pulmonol. 1995 Apr;19(4):231-42. Unique Identifier : AIDSLINE MED/95342635; Bye MR; Department of Pediatrics, Columbia University College of; Physicians & Surgeons, New York, NY 10032, USA.
Unseen and unheard [news]: Nurs Times. 1995 Jun 14-20;91(24):17. Unique Identifier : AIDSLINE MED/95342701; Plant F
Cytologic diagnosis of anal intraepithelial neoplasia using smears and cytyc thin-preps.: Mod Pathol. 1995 Apr;8(3):270-4. Unique Identifier : AIDSLINE MED/95342893; Sherman ME; Friedman HB; Busseniers AE; Kelly WF; Carner TC; Saah AJ; George Washington University School of Medicine, Washington, DC,; USA.; To investigate the optimal cytologic method for detecting anal intraepithelial neoplasia, the quality and diagnostic findings in 117 conventionally prepared smears and 191 CYTYC Thin-Preps were compared. Samples were obtained with a dacron swab from subjects participating in a longitudinal study of gay or bisexual men
Correspondence re: Pamela Danque et al. HLA-DR expression in bile duct damage in hepatitis C. Mod Pathol 6:327, 1993 [letter; comment]: Mod Pathol. 1995 Apr;8(3):341-2. Unique Identifier : AIDSLINE MED/95342905; Guido M
Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV.: Planta Med. 1995 Jun;61(3):237-41. Unique Identifier : AIDSLINE MED/95343014; Hayashi K; Kamiya M; Hayashi T; Department of Virology, Toyama Medical and Pharmaceutical; University, Japan.; The steam distillate prepared from fresh plants of Houttuynia cordata Thunb. (Saururaceae) was found to have direct inhibitory activity against herpes simplex virus type 1 (HSV-1), influenza virus, and human immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but not against poliovirus and coxsackie-vi
Invasive pulmonary aspergillosis in AIDS: radiographic, CT, and pathologic findings.: Radiology. 1995 Aug;196(2):409-14. Unique Identifier : AIDSLINE MED/95343104; Staples CA; Kang EY; Wright JL; Phillips P; Muller NL; Department of Radiology, University of British Columbia and St; Paul's Hospital, Vancouver, Canada.; PURPOSE: To review the radiographic and computed tomographic (CT) manifestations of invasive pulmonary aspergillosis and to correlate the imaging and pathologic findings in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: Chest radiographs, CT scans, and pathologic specimens were reviewe
[34-year-old male with HIV infection hospitalized for fever and respiratory failure (clinical conference)]: Rev Clin Esp. 1995 May;195(5):340-50. Unique Identifier : AIDSLINE MED/95343197; Miro Meda JM; Allende Monclus H; Gonzalez Minguez C; Pahissa Berga A; Falco V; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Barcelona.
[What role is left to sperm banks in 1995?]: Rev Med Liege. 1995 Jun;50(6):254-8. Unique Identifier : AIDSLINE MED/95343256; Demoulin A; Lambotte R; Departement de Gynecologie-Obstetrique, Universite de Liege.
[Application of DRGs at a regional hospital]: Rev Sanid Hig Publica (Madr). 1994 Sep-Dec;68(5-6):579-87. Unique Identifier : AIDSLINE MED/95343290; Suarez-Varela MM; Segarra Castello L; Lloret Caballeria A; Villuendas Gorrochategui A; Area de Medicina Preventiva y Salud Publica, Bromatologia,; Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad; de Valencia.; BACKGROUND: Of among the different measures systems of hospital production, we adopted the Diagnosis Related Groups (DRG) approach for the management of the cases series of the Arnau de Vilanova Hospital (Valencia, Spain ). The use of hospital services makes it possible to establish
AIDS-related cholangitis: diagnostic features and course in four patients [see comments]: Scott Med J. 1995 Apr;40(2):53-4. Unique Identifier : AIDSLINE MED/95343329; Bird GL; Kennedy DH; Forrest JA; Department of Gastroenterology, Stobhill General Hospital,; Glasgow.; Radiological features of sclerosing cholangitis are an uncommon but well recognised complication of HIV infection in homosexual males. In this report we document the clinical features and course of the disease in four patients. Four homosexual males with established AIDS were referred in 1990-92. Three of the four had
Top scientists come to defense of AIDS research office [news]: Science. 1995 Jul 14;269(5221):151. Unique Identifier : AIDSLINE MED/95343332
How the TH2 response is marshaled [news; comment]: Science. 1995 Jul 14;269(5221):161. Unique Identifier : AIDSLINE MED/95343335; Cohen J
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells [see comments]: Science. 1995 Jul 14;269(5221):245-7. Unique Identifier : AIDSLINE MED/95343350; Pernis A; Gupta S; Gollob KJ; Garfein E; Coffman RL; Schindler C; Rothman P; Department of Medicine, College of Physicians and Surgeons,; Columbia University, New York, NY 10032, USA.; The ability of interferon gamma (IFN-gamma) to inhibit the proliferation of type 2 T helper cells (TH2), but not that of type 1 (TH1) cells, suggests that helper cell subsets might differ in their activation of the IFN-gamma signaling pathway. The IFN-gamma-inducible signal transducing factor (STF-IFN gamma) was activ
AIDS research: who should hold the purse strings? [news]: Science. 1995 Jul 21;269(5222):292. Unique Identifier : AIDSLINE MED/95343354; Cohen J
FDA panel OKs baboon marrow transplant [news]: Science. 1995 Jul 21;269(5222):293-4. Unique Identifier : AIDSLINE MED/95343356; Pennisi E
[AIDS mortality in Mexico from 1983 to 1992. The trends and years of potential life lost]: Salud Publica Mex. 1995 Mar-Apr;37(2):140-8. Unique Identifier : AIDSLINE MED/95343377; Izazola-Licea JA; Valdez-Garcia M; Sanchez-Perez HJ; del Rio-Chiriboga C; OBJECTIVE: To describe trends in AIDS mortality in Mexico from 1983 to 1992, as well as years of potential life lost (YPLL) and years of potential productive life lost (YPPLL) due to AIDS. MATERIAL AND METHODS: A retrospective review of databases available in Mexico that code morta
[The principle results of the mortality statistics in Mexico, 1993]: Salud Publica Mex. 1995 Mar-Apr;37(2):171-8. Unique Identifier : AIDSLINE MED/95343381
High consumption of fatty fish from the Baltic Sea is associated with changes in human lymphocyte subset levels.: Toxicol Lett. 1995 May;77(1-3):335-42. Unique Identifier : AIDSLINE MED/95343423; Hagmar L; Hallberg T; Leja M; Nilsson A; Schutz A; Department of Occupational and Environmental Medicine, University; Hospital, Lund, Sweden.; Fatty fish from the Baltic Sea accumulate immunotoxic persist