Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.
Distribution of HLA in a population of Black patients with HTLV-I associated adult T-cell leukemia/lymphoma (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 36:A1667 1995. Unique Identifier : AIDSLINE ICDB/95609442 White JD; Manns A; Johnson JA; Waldmann TA; NCI, Bethesda, MD 20892
Abstract:
Human leukocyte antigens (HLA) play an important role in regulating the immune response to infectious agents and determinants of malignant transformation. We compared the HLA frequency of 25 Black patients with adult T-cell leukemia/lymphoma (ATL) referred for therapy, to a racially similar, healthy control (CO) population of HTLV-I + (n=45) and HTLV-I- (n=51) individuals. Serological typing of HLA class I and class II antigens (Ags) was performed, HLA frequencies were calculated and comparisons were made with Chi2 Yates continuity correction or Fisher's exact test. 21 ATL patients originated from the Caribbean and 4 from the US. No statistical difference in HLA frequencies was noted between groups so data from all 25 patients were combined for subsequent analyses. Four Ags (A28, A36, DR6 and DR53) were found to have a higher frequency in the ATL patients than in the CO group. Comparing the ATL patients against only the HTLV-I + CO these Ags and a fifth (B18) were still significantly more frequent in the ATL group with uncorrected two-tailed P values of less than 0.05. When P values were corrected for the number of Ags tested none were significant. Two other Ags (shown in a table) were found in higher frequency in the CO group than in the ATL group. In summary, a subgroup of Black patients with ATL has HLA frequencies that differ from a racially similar reference population suggesting the possibility of a genetic predisposition for ATL. Further study is required to confirm these findings.
Keywords: Adult Cell Transformation, Neoplastic/GENETICS Gene Expression Regulation, Leukemic/PHYSIOLOGY Gene Frequency Histocompatibility Antigens Class I/*GENETICS Histocompatibility Antigens Class II/*GENETICS Human Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*GENETICS/ IMMUNOLOGY Negroid Race/*GENETICS ABSTRACT
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.
