Effect of HTLV-I infection on incidence of non-Hodgkin's lymphoma in Jamaica and Trinidad (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Effect of HTLV-I infection on incidence of non-Hodgkin's lymphoma in Jamaica and Trinidad (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 36:A1668 1995. Unique Identifier : AIDSLINE ICDB/95609443
Cleghorn F; Manns A; Falk R; Hartge P; Jaffe E; Hanchard B; Bartholomew C; Blattner W; DCE/NCI/NIH, Bethesda, MD

Abstract: Incidence rates for non-Hodgkin's lymphoma (NHL) were calculated using all incident cases diagnosed in Jamaica during 1984-1987, and all incident cases of African descent in Trinidad during 1986-1990. HTLV-I status was ascertained by serologic methods and rates are based on 1980 population census reports for both countries (combined pop 4 million). Rates were computed for all lymphomas and HTLV-I exposed and unexposed lymphomas, according to age and sex. Differences in absolute risk for NHL between HTLV-I exposed and unexposed groups were examined. The annualized NHL incidence rate in Jamaica and Trinidad/Tobago was 3.6/100,000 PY. Overall, the incidence of NHL increased with age, being highest in those over 60 years old, and age-specific rates were higher in males than in females at all ages. Among HTLV unexposed persons this pattern persisted, with no significant difference between age specific rates for both sexes; and rates were comparable with those from other developing countries. In the HTLV-I exposed group, NHL rates were significantly higher than among HTLV unexposed in all age categories except the oldest (60+ years) and declined with age. Approximately half of all NHL in these locales, particularly among those less than 60 years old, is explained by HTLV-I infection.

Keywords: Adult Aged Cross-Sectional Studies *Developing Countries Female Human HTLV-I Infections/*EPIDEMIOLOGY Incidence Jamaica Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*EPIDEMIOLOGY Male Middle Age *Negroid Race Risk Factors Trinidad and Tobago ABSTRACT

951130
M95B0949

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