Increasing incidence of primary central nervous system lymphoma (PCNSL) in the elderly: Florida Cancer Data Systems (FCDS) (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Increasing incidence of primary central nervous system lymphoma (PCNSL) in the elderly: Florida Cancer Data Systems (FCDS) (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 14:A421 1995. Unique Identifier : AIDSLINE ICDB/95613574
Phuphanich S; Werner M; Lyman G; Neuro-Oncology Program and Medical Oncology Services, H. Lee; Moffitt Cancer Center and Research Institute, Tampa, FL

Abstract: PCNSL is a rare neoplasm but one that is being seen with increasing frequency even in immunocompetent patients and also in patients with Acquired Immune Deficiency Syndrome (AIDS). We analyzed 6357 cases of primary malignant brain tumors reported to the FCDS from 1981-1989. Incidence rates per 100,000 population were calculated. Incidence density ratios (IDRs) were calculated for 1986-1989 in relation to 1981-1984. Tumor incidence at ages 20-64 increased from 5.7 (1981-84) to 5.9 (1986-89) with an IDR of 1.05 (not significant) but the incidence at ages 65+ rose from 14.8 (1981-84) to 18.3 (1986-89) with an IDR of 1.23 (p less than 0.001). IDRs in those ages 65+ were highest 3.56 (p less than 0.001) for PCNSL and 2.7 (p less than 0.001) for anaplastic astrocytoma. There was also a significant increase in the number of PCNSL in ages 20-65. Data are shown in a table. The increase in younger age groups may be due to the increasing incidence of AIDS. However, the incidence of AIDS has not been rising in the elderly, suggesting that PCNSL in immunocompetent individuals has increased in this age group. We conclude that this increase is independent of increased case ascertainment associated with the introduction of CT or MRI scans because of widespread availability of these studies in both periods and not related to the increasing incidence of AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Adult Aged Brain Neoplasms/*EPIDEMIOLOGY Florida/EPIDEMIOLOGY Human Information Systems Lymphoma/*EPIDEMIOLOGY Middle Age ABSTRACT

KWDacquiredimmunodeficiencysyndrome/KWDepidemiologyadultagedbrainneoplasms/KWDepidemiologyflorida/epidemiologyhumaninformationsystemslymphoma/KWDepidemiologymiddleageabstract
951130
M95B0943

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