Reduced immunoglobulin kappa/lambda light chain ratio in perinatally HIV-1-infected children. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Reduced immunoglobulin kappa/lambda light chain ratio in perinatally HIV-1-infected children.

Pediatr AIDS HIV Infect. 1994 Dec;5(6):344-9. Unique Identifier : AIDSLINE AIDS/95368370
Saitta M; Gaido F; Palomba E; Cirina P; Giaccone A; Ciuti E; Tovo P; Laboratory of Clinical Chemistry and Microbiology, Regina; Margherita Children's Hospital, Turin, Italy.

Abstract: In 27 perinatally human immunodeficiency virus type 1 (HIV-1)-infected children, we measured, by immunonephelometry, the kappa/lambda light chain ratio (KLR) of serum immunoglobulins. The latter is a recently available laboratory index reflecting the balance between the synthesis of K isotypes and L isotypes. KLR was consistent over time in each subject, and was significantly lower than that of an age-matched normal population, independently of disease status and therapy. These data indicate a bias, in these subjects, to produce preferentially lambda rather than kappa light chains, contributing to the multiple B-cell abnormalities in HIV-1-infected children.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/TRANSMISSION Case-Control Studies Child Child, Preschool *Disease Transmission, Vertical Female Human HIV Antibodies/BIOSYNTHESIS HIV-1/IMMUNOLOGY Immunoglobulins, kappa-Chain/*BIOSYNTHESIS Immunoglobulins, lambda-Chain/*BIOSYNTHESIS Infant Male Pregnancy Pregnancy Complications, Infectious/EPIDEMIOLOGY/IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunology/transmissioncase-controlstudieschildchild,preschoolKWDdiseasetransmission,verticalfemalehumanhivantibodies/biosynthesishiv-1/immunologyimmunoglobulins,kappa-chain/KWDbiosynthesisimmunoglobulins,lambda-chain/KWDbiosynthesisinfantmalepregnancypregnancycomplications,infectious/epidemiology/immunologysupport,non-uKWDsKWDgov'tjournalarticle
951130
M95B0940

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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