Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda.

Pediatr AIDS HIV Infect. 1994 Dec;5(6):350-6. Unique Identifier : AIDSLINE AIDS/95368371
Epstein H; Guay L; Hom D; Mmiro F; Ndugwa C; Marum L; Olness K; Piwowar E; Kataaha P; Baenziger J; et al; Department of Biochemistry, Makerere University, Kampala, Uganda.

Abstract: This study evaluated the association between reactivity of maternal antibody to human immunodeficiency virus type 1 (HIV-1) V3 loop peptides and perinatal transmission in Uganda. Plasma from 40 HIV-1-infected mothers (20 transmitting and 20 nontransmitting mothers) and 31 uninfected mothers in Uganda were tested for reactivity and antibody titer to synthetic peptides representing V3 loop sequences from HIV-1 strains MN, SF2, LAI, ZR6, and CM235 and consensus peptides CA, CB, and CD. No significant differences were found between 20 transmitting mothers and 20 nontransmitting mothers in terms of percent reactivity or titer of antibody to any of the V3 loop peptides tested. Use of a multivariable logistic model to adjust for beta-2 microglobulin level as a confounding variable of stage of infection did not help demonstrate an association except possibly for the ZR6 peptide. These data suggest that neither reactivity nor maternal antibody titer to V3 loop peptides are protective against perinatal transmission of HIV-1 in Uganda.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/TRANSMISSION Amino Acid Sequence Case-Control Studies Disease Transmission, Vertical Female Human HIV Antibodies/*BIOSYNTHESIS HIV Envelope Protein gp120/*IMMUNOLOGY HIV Seronegativity/IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY HIV-1/IMMUNOLOGY Molecular Sequence Data Peptide Fragments/*IMMUNOLOGY Pregnancy Pregnancy Complications, Infectious/*IMMUNOLOGY/VIROLOGY Uganda/EPIDEMIOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunology/transmissionaminoacidsequencecase-controlstudiesdiseasetransmission,verticalfemalehumanhivantibodies/KWDbiosynthesishivenvelopeproteingp120/KWDimmunologyhivseronegativity/immunologyhivseropositivity/immunologyhiv-1/immunologymolecularsequencedatapeptidefragments/KWDimmunologypregnancypregnancycomplications,infectious/KWDimmunology/virologyuganda/epidemiologyjournalarticle
951130
M95B0939

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