Coinfection with herpesviruses in young children of HIV-infected women.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Coinfection with herpesviruses in young children of HIV-infected women.

Pediatr AIDS HIV Infect. 1995 Apr;6(2):75-82. Unique Identifier : AIDSLINE AIDS/95368379
Sever JL; Rakusan TA; Ellaurie M; Frenkel N; Wyatt LS; Campos JM; O'Donnell RM; Price MV; Children's National Medical Center, George Washington University; Medical Center, Washington, D.C., USA.

Abstract: Coinfection with herpesviruses in young children born to human immunodeficiency virus (HIV)-infected women was studied with blood samples from children who were 9-12 months and 15-24 months of age. Three groups of children were included: (I) HIV-uninfected, asymptomatic (HIV-); (II) polymerase chain reaction (PCR) and/or culture-positive and asymptomatic or mildly symptomatic (HIV+ asymptomatic); and (III) PCR and/or culture-positive and symptomatic (HIV+ symptomatic). Significantly more of the HIV+ symptomatic patients had cytomegalovirus (CMV) antibody than the HIV patients. In addition, CMV antibody levels were significantly higher in the HIV+ symptomatic patients than in either of the other two groups. Human herpesvirus 7 (HHV-7) antibody titers were significantly different among the three groups of patients; however, no pairwise comparisons were significant. No differences were found for HHV-6 or Epstein-Barr virus (EBV) antibody frequencies or titers. These findings suggest that infection with CMV is a cofactor or an opportunistic infection causing symptomatic HIV infections in young children.

Keywords: Antibodies, Viral/ANALYSIS Case-Control Studies Child, Preschool Comparative Study Cytomegalovirus/IMMUNOLOGY/ISOLATION & PURIF CD4 Lymphocyte Count Disease Transmission, Vertical Female Herpesviridae Infections/*COMPLICATIONS/IMMUNOLOGY Herpesvirus 4, Human/IMMUNOLOGY/ISOLATION & PURIF Herpesvirus 6, Human/IMMUNOLOGY/ISOLATION & PURIF Herpesvirus 7, Human/IMMUNOLOGY/ISOLATION & PURIF Human HIV Infections/*COMPLICATIONS/IMMUNOLOGY/TRANSMISSION HIV Seronegativity HIV Seropositivity/COMPLICATIONS/IMMUNOLOGY IgM/ANALYSIS Infant Male Pregnancy Pregnancy Complications, Infectious/IMMUNOLOGY/*VIROLOGY JOURNAL ARTICLE

951130
M95B0931

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